aging

Summary

Summary: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Top Publications

  1. pmc The hallmarks of aging
    Carlos Lopez-Otin
    Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Oncologia IUOPA, Universidad de Oviedo, Oviedo, Spain
    Cell 153:1194-217. 2013
  2. pmc Autophagy in the pathogenesis of disease
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 132:27-42. 2008
  3. pmc mTOR: from growth signal integration to cancer, diabetes and ageing
    Roberto Zoncu
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Mol Cell Biol 12:21-35. 2011
  4. pmc Extending healthy life span--from yeast to humans
    Luigi Fontana
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 328:321-6. 2010
  5. pmc Four faces of cellular senescence
    Francis Rodier
    The Research Centre of the University of Montreal Hospital Centre Institut du Cancer de Montréal, Montreal, Quebec, Canada
    J Cell Biol 192:547-56. 2011
  6. pmc Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
    Julie A Mattison
    Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, Dickerson, Maryland 20842, USA
    Nature 489:318-21. 2012
  7. doi The genetics of ageing
    Cynthia J Kenyon
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
    Nature 464:504-12. 2010
  8. pmc Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People
    Alfonso J Cruz-Jentoft
    Hospital Universitario Ramon y Cajal, Madrid, Spain
    Age Ageing 39:412-23. 2010
  9. pmc Ageing populations: the challenges ahead
    Kaare Christensen
    Danish Ageing Research Centre, University of Southern Denmark, Odense, Denmark
    Lancet 374:1196-208. 2009
  10. doi Autophagy and aging
    David C Rubinsztein
    Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0XY, UK
    Cell 146:682-95. 2011

Research Grants

  1. TRANSGENIC MICE, AGING, CANCER, AND OXIDATIVE DAMAGE
    Arlan Richardson; Fiscal Year: 2001
  2. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
  3. Lauren Endres; Fiscal Year: 2014
  4. MERVYN N WEITZMANN; Fiscal Year: 2016
  5. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
  6. KEVIN ROBERT VINCENT; Fiscal Year: 2014
  7. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
  8. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
  9. Statin modulation of immunotherapy for Alzheimer disease
    Jun Tan; Fiscal Year: 2012
  10. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013

Detail Information

Publications409 found, 100 shown here

  1. pmc The hallmarks of aging
    Carlos Lopez-Otin
    Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Oncologia IUOPA, Universidad de Oviedo, Oviedo, Spain
    Cell 153:1194-217. 2013
    b>Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death...
  2. pmc Autophagy in the pathogenesis of disease
    Beth Levine
    Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 132:27-42. 2008
    ..adaptive role to protect organisms against diverse pathologies, including infections, cancer, neurodegeneration, aging, and heart disease...
  3. pmc mTOR: from growth signal integration to cancer, diabetes and ageing
    Roberto Zoncu
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Rev Mol Cell Biol 12:21-35. 2011
    ..In the past few years, a significant advance in our understanding of the regulation and functions of mTOR has revealed the crucial involvement of this signalling pathway in the onset and progression of diabetes, cancer and ageing...
  4. pmc Extending healthy life span--from yeast to humans
    Luigi Fontana
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 328:321-6. 2010
    ..Dietary restriction and reduced activity of nutrient-sensing pathways may thus slow aging by similar mechanisms, which have been conserved during evolution...
  5. pmc Four faces of cellular senescence
    Francis Rodier
    The Research Centre of the University of Montreal Hospital Centre Institut du Cancer de Montréal, Montreal, Quebec, Canada
    J Cell Biol 192:547-56. 2011
    ..tumorigenesis, cellular senescence might also promote tissue repair and fuel inflammation associated with aging and cancer progression...
  6. pmc Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
    Julie A Mattison
    Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, Dickerson, Maryland 20842, USA
    Nature 489:318-21. 2012
    ..We report here that a CR regimen implemented in young and older age rhesus monkeys at the National Institute on Aging (NIA) has not improved survival outcomes...
  7. doi The genetics of ageing
    Cynthia J Kenyon
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California 94158, USA
    Nature 464:504-12. 2010
    ..Which genes can extend lifespan? Can we augment their activities and live even longer? After centuries of wistful poetry and wild imagination, we are now getting answers, often unexpected ones, to these fundamental questions...
  8. pmc Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People
    Alfonso J Cruz-Jentoft
    Hospital Universitario Ramon y Cajal, Madrid, Spain
    Age Ageing 39:412-23. 2010
    ..Association of Gerontology and Geriatrics-European Region and the International Association of Nutrition and Aging. These organisations endorsed the findings in the final document...
  9. pmc Ageing populations: the challenges ahead
    Kaare Christensen
    Danish Ageing Research Centre, University of Southern Denmark, Odense, Denmark
    Lancet 374:1196-208. 2009
    ..This finding, together with technological and medical development and redistribution of work, will be important for our chances to meet the challenges of ageing populations...
  10. doi Autophagy and aging
    David C Rubinsztein
    Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0XY, UK
    Cell 146:682-95. 2011
    ..inhibition of autophagy induces degenerative changes in mammalian tissues that resemble those associated with aging, and normal and pathological aging are often associated with a reduced autophagic potential...
  11. ncbi Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    E H Corder
    Department of Medicine, Joseph and Kathleen Bryan Alzheimer s Disease Research Center, Duke University Medical Center, Durham, NC 27710
    Science 261:921-3. 1993
    ..Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80...
  12. pmc Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    Jean Philippe Coppe
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    PLoS Biol 6:2853-68. 2008
    ..Moreover, they suggest a cell-nonautonomous mechanism by which p53 can restrain, and oncogenic RAS can promote, the development of age-related cancer by altering the tissue microenvironment...
  13. pmc mTOR is a key modulator of ageing and age-related disease
    Simon C Johnson
    Department of Pathology, University of Washington, Seattle, Washington 98195, USA
    Nature 493:338-45. 2013
    ..Although adverse side effects currently preclude use in otherwise healthy individuals, drugs that target the mTOR pathway could one day become widely used to slow ageing and reduce age-related pathologies in humans...
  14. pmc HIV infection, inflammation, immunosenescence, and aging
    Steven G Deeks
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, CA, USA
    Annu Rev Med 62:141-55. 2011
    ..treated patients remain at higher than expected risk for a number of complications typically associated with aging, including cardiovascular disease, cancer, osteoporosis, and other end-organ diseases...
  15. ncbi A voxel-based morphometric study of ageing in 465 normal adult human brains
    C D Good
    Wellcome Department of Cognitive Neurology, Institute of Neurology, London, United Kingdom
    Neuroimage 14:21-36. 2001
    ..There was no interaction of age with sex for regionally specific effects. These results corroborate previous reports and indicate that VBM is a useful technique for studying structural brain correlates of ageing through life in humans...
  16. pmc Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging
    Ana P Gomes
    Glenn Labs for the Biological Mechanisms of Aging, Department of Genetics, Harvard Medical School, Boston, MA 02115, USA Center for Neurosciences and Cell Biology, 3004 517 Coimbra, Portugal Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, 3004 517 Coimbra, Portugal
    Cell 155:1624-38. 2013
    ..Mitochondrial dysfunction is a hallmark of aging, but its causes are debated...
  17. pmc With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging
    Pankaj Kapahi
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Cell Metab 11:453-65. 2010
    ..Studies in flies, worms, yeast, and mice support the notion that the TOR signaling network modulates aging. TOR is also emerging as a robust mediator of the protective effects of various forms of dietary restriction (DR), ..
  18. ncbi Functional neurogenesis in the adult hippocampus
    Henriette van Praag
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 415:1030-4. 2002
    ..Our findings demonstrate that newly generated cells mature into functional neurons in the adult mammalian brain...
  19. pmc Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer
    Andrew E Teschendorff
    University College London, London WC1E 6BT, UK
    Genome Res 20:440-6. 2010
    ..These findings shed substantial novel insights into the epigenetic effects of aging and support the view that age may predispose to malignant transformation by irreversibly stabilizing stem cell ..
  20. doi Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
    Vladimir N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, St Petersburg, Russia
    Cell Cycle 10:4230-6. 2011
    The nutrient-sensing TOR (target of rapamycin) pathway is involved in cellular and organismal aging. Rapamycin, an inhibitor of TOR, extends lifespan in yeast, fruit flies and genetically heterogeneous mice...
  21. doi Aging with multimorbidity: a systematic review of the literature
    Alessandra Marengoni
    Aging Research Center, NVS Department, Karolinska Institutet and Stockholm University, Sweden
    Ageing Res Rev 10:430-9. 2011
    ..New insights in this field can lead to the identification of preventive strategies and better treatment of multimorbid patients...
  22. ncbi Oxidants, oxidative stress and the biology of ageing
    T Finkel
    Laboratory of Molecular Biology, National Heart, Lung, and Blood Institute National Institutes of Health, Bethesda, Maryland 20892 1622, USA
    Nature 408:239-47. 2000
    ..Here we review evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span...
  23. ncbi Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
    Raul Mostoslavsky
    Howard Hughes Medical Institute, The Children s Hospital, CBR Institute for Biomedical Research, Harvard University Medical School, Boston, MA 02115, USA
    Cell 124:315-29. 2006
    The Sir2 histone deacetylase functions as a chromatin silencer to regulate recombination, genomic stability, and aging in budding yeast...
  24. pmc Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice
    Richard A Miller
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 66:191-201. 2011
    ..on mice is likely to help delineate the role of the mammalian target of rapamycin complexes in the regulation of aging rate and age-dependent diseases and may help to guide a search for drugs that retard some or all of the diseases ..
  25. doi Altered histone acetylation is associated with age-dependent memory impairment in mice
    Shahaf Peleg
    Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Grisebach Str 5, D 37077 Goettingen, Germany
    Science 328:753-6. 2010
    ..Here we show that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity...
  26. pmc Exercise enhances learning and hippocampal neurogenesis in aged mice
    Henriette van Praag
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 25:8680-5. 2005
    b>Aging causes changes in the hippocampus that may lead to cognitive decline in older adults. In young animals, exercise increases hippocampal neurogenesis and improves learning...
  27. ncbi Mitochondria, oxidants, and aging
    Robert S Balaban
    Laboratory of Cardiac Energetics, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 120:483-95. 2005
    The free radical theory of aging postulates that the production of intracellular reactive oxygen species is the major determinant of life span...
  28. pmc Rapamycin extends murine lifespan but has limited effects on aging
    Frauke Neff
    Institute of Pathology, Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    J Clin Invest 123:3272-91. 2013
    b>Aging is a major risk factor for a large number of disorders and functional impairments...
  29. pmc Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
    Linda S Steelman
    Department of Microbiology and Immunology, East Carolina University, Greenville, NC 27858, USA
    Aging (Albany NY) 3:192-222. 2011
    ..Finally the recently described roles of these pathways in cancer stem cells, cellular senescence and aging will be evaluated. Controlling the expression of these pathways could ameliorate human health.
  30. pmc Mitochondria and the autophagy-inflammation-cell death axis in organismal aging
    Douglas R Green
    Department of Immunology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Science 333:1109-12. 2011
    ..Thus, a combination of mitochondrial dysfunction and insufficient autophagy may contribute to multiple aging-associated pathologies.
  31. ncbi An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration
    G S Hageman
    Department of Ophthalmology and Visual Sciences, The University of Iowa Center for Macular Degeneration, PFP 11190E, 200 Hawkins Drive, The University of Iowa, Iowa City, IA 52240, USA
    Prog Retin Eye Res 20:705-32. 2001
    ..Although it has been proposed that a threshold event occurs during normal aging which leads to AMD, the sequelae of biochemical, cellular, and/or molecular events leading to the development of ..
  32. pmc Recent progress in the biology and physiology of sirtuins
    Toren Finkel
    Translational Medicine Branch, National Heart Lung and Blood Institute, US National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 460:587-91. 2009
    ..Here we review the recent progress in sirtuin biology, the role these proteins have in various age-related diseases and the tantalizing notion that the activity of this family of enzymes somehow regulates how long we live...
  33. pmc The p53 network: cellular and systemic DNA damage responses in aging and cancer
    H Christian Reinhardt
    Cologne Excellence Cluster on Cellular Stress Response in Aging Associated Diseases, University of Cologne, 50674 Cologne, Germany
    Trends Genet 28:128-36. 2012
    ..stem and progenitor cell pools, thus promoting tissue degeneration and organ failure, which are both hallmarks of aging. p53 signaling is also involved in mediating non-cell-autonomous interactions with the innate immune system and in ..
  34. doi Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program
    Mikhail V Blagosklonny
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA
    Cell Cycle 9:3151-6. 2010
    A half century ago, the antagonistic pleiotropy (AP) theory had solved a mystery of aging, by postulating genes beneficial early in life at the cost of aging...
  35. ncbi Free radicals in the physiological control of cell function
    Wulf Dröge
    Division of Immunochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Physiol Rev 82:47-95. 2002
    ..In addition, free radicals have been implicated in the mechanism of senescence. That the process of aging may result, at least in part, from radical-mediated oxidative damage was proposed more than 40 years ago by Harman ..
  36. ncbi Regional brain changes in aging healthy adults: general trends, individual differences and modifiers
    Naftali Raz
    Department of Psychology and Institute of Gerontology, Wayne State University, 87 East Ferry St, 226 Knapp Building, Detroit, MI 48202, USA
    Cereb Cortex 15:1676-89. 2005
    Brain aging research relies mostly on cross-sectional studies, which infer true changes from age differences. We present longitudinal measures of five-year change in the regional brain volumes in healthy adults...
  37. ncbi Reduced resting-state brain activity in the "default network" in normal aging
    J S Damoiseaux
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Cereb Cortex 18:1856-64. 2008
    Normal aging is associated with cognitive decline. Functions such as attention, information processing, and working memory are compromised...
  38. pmc Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
    Richard I Morimoto
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    Genes Dev 22:1427-38. 2008
    ..decline in biosynthetic and repair activities that compromises the integrity of the proteome is influenced strongly by genes that control aging, thus linking stress and protein homeostasis with the health and life span of the organism.
  39. pmc Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster
    Ivana Bjedov
    Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, UK
    Cell Metab 11:35-46. 2010
    ..Rapamycin could increase life span of weak insulin/Igf signaling (IIS) pathway mutants and of flies with life span maximized by dietary restriction, indicating additional mechanisms...
  40. pmc MicroRNA, mRNA, and protein expression link development and aging in human and macaque brain
    Mehmet Somel
    Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Genome Res 20:1207-18. 2010
    ..levels determine differentiation of tissues involved in development and are associated with functional decline in aging. Although development is tightly regulated, the transition between development and aging, as well as regulation of ..
  41. pmc Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
    Shinichi Someya
    Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, 53706, USA
    Cell 143:802-12. 2010
    ..identify Sirt3 as an essential player in enhancing the mitochondrial glutathione antioxidant defense system during CR and suggest that Sirt3-dependent mitochondrial adaptations may be a central mechanism of aging retardation in mammals.
  42. pmc Detectable clonal mosaicism and its relationship to aging and cancer
    Kevin B Jacobs
    Division of Cancer Epidemiology and Genetics, National Cancer Institute NCI, Rockville, Maryland, USA
    Nat Genet 44:651-8. 2012
    ..4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases...
  43. pmc Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?
    David Gems
    Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom
    Antioxid Redox Signal 19:321-9. 2013
    The biological mechanisms at the heart of the aging process are a long-standing mystery...
  44. ncbi The processing-speed theory of adult age differences in cognition
    T A Salthouse
    Georgia Institute of Technology, Atlanta 30332 0170, USA
    Psychol Rev 103:403-28. 1996
    ....
  45. ncbi Aging gracefully: compensatory brain activity in high-performing older adults
    Roberto Cabeza
    Center for Cognitive Neurosciences, Duke University, B203 LSRC Building, Durham, North Carolina 27708, USA
    Neuroimage 17:1394-402. 2002
    ..We investigated the neural basis of these different aging patterns using positron emission tomography (PET)...
  46. pmc Meta-analysis of age-related gene expression profiles identifies common signatures of aging
    João Pedro de Magalhães
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Bioinformatics 25:875-81. 2009
    Numerous microarray studies of aging have been conducted, yet given the noisy nature of gene expression changes with age, elucidating the transcriptional features of aging and how these relate to physiological, biochemical and ..
  47. ncbi Inflamm-aging. An evolutionary perspective on immunosenescence
    C Franceschi
    Department of Experimental Pathology, University of Bologna, Italy
    Ann N Y Acad Sci 908:244-54. 2000
    In this paper we extend the "network theory of aging," and we argue that a global reduction in the capacity to cope with a variety of stressors and a concomitant progressive increase in proinflammatory status are major characteristics of ..
  48. ncbi Hemispheric asymmetry reduction in older adults: the HAROLD model
    Roberto Cabeza
    Center for Cognitive Neuroscience, Duke University, Durham, North Carolina 27708, USA
    Psychol Aging 17:85-100. 2002
    A model of the effects of aging on brain activity during cognitive performance is introduced...
  49. ncbi Opposing activities protect against age-onset proteotoxicity
    Ehud Cohen
    Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 313:1604-10. 2006
    ..Aggregation-mediated Abeta(1-42) toxicity was reduced in Caenorhabditis elegans when aging was slowed by decreased insulin/insulin growth factor-1-like signaling (IIS)...
  50. pmc Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    Suzanne E Hickman
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, and Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129
    J Neurosci 28:8354-60. 2008
    ..To determine the effects of aging and Abeta deposition on microglial ability to clear Abeta, we used quantitative PCR to analyze gene expression in ..
  51. pmc Molecular damage in cancer: an argument for mTOR-driven aging
    Mikhail V Blagosklonny
    Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Aging (Albany NY) 3:1130-41. 2011
    Despite common belief, accumulation of molecular damage does not play a key role in aging. Still, cancer (an age-related disease) is initiated by molecular damage...
  52. pmc Caloric restriction delays disease onset and mortality in rhesus monkeys
    Ricki J Colman
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53715, USA
    Science 325:201-4. 2009
    Caloric restriction (CR), without malnutrition, delays aging and extends life span in diverse species; however, its effect on resistance to illness and mortality in primates has not been clearly established...
  53. pmc Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
    Clifford R Jack
    Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA jack cliff
    Lancet Neurol 9:119-28. 2010
    ....
  54. pmc Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases
    Sung Jun Park
    Laboratory of Obesity and Aging Research, Genetics and Developmental Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 148:421-33. 2012
    ..Therefore, administration of PDE4 inhibitors may also protect against and ameliorate the symptoms of metabolic diseases associated with aging.
  55. ncbi Telomeres and human disease: ageing, cancer and beyond
    Maria A Blasco
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre CNIO, 28029 Madrid, Spain
    Nat Rev Genet 6:611-22. 2005
    ..These findings have inspired a number of potential therapeutic strategies that are based on telomerase and telomeres...
  56. pmc Age- and gender-related differences in the cortical anatomical network
    Gaolang Gong
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 29:15684-93. 2009
    Neuroanatomical differences attributable to aging and gender have been well documented, and these differences may be associated with differences in behaviors and cognitive performance...
  57. pmc Telomere dysfunction induces metabolic and mitochondrial compromise
    Ergun Sahin
    Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 470:359-65. 2011
    ..We propose that this telomere-p53-PGC axis contributes to organ and metabolic failure and to diminishing organismal fitness in the setting of telomere dysfunction...
  58. ncbi Regulation of aging and age-related disease by DAF-16 and heat-shock factor
    Ao Lin Hsu
    Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94143 2200, USA
    Science 300:1142-5. 2003
    The Caenorhabditis elegans transcription factor HSF-1, which regulates the heat-shock response, also influences aging. Reducing hsf-1 activity accelerates tissue aging and shortens life-span, and we show that hsf-1 overexpression extends ..
  59. pmc Drusen proteome analysis: an approach to the etiology of age-related macular degeneration
    John W Crabb
    Cole Eye Institute and Lerner Research Institute, Cleveland Clinic Foundation, and Department of Chemistry, Case Western Reserve University, OH 44195, USA
    Proc Natl Acad Sci U S A 99:14682-7. 2002
    ..These data strongly support the hypothesis that oxidative injury contributes to the pathogenesis of AMD and suggest that oxidative protein modifications may have a critical role in drusen formation...
  60. pmc Mammalian sirtuins: biological insights and disease relevance
    Marcia C Haigis
    Glenn Laboratories for the Molecular Biology of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Pathol 5:253-95. 2010
    b>Aging is accompanied by a decline in the healthy function of multiple organ systems, leading to increased incidence and mortality from diseases such as type II diabetes mellitus, neurodegenerative diseases, cancer, and cardiovascular ..
  61. pmc Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila
    Camilla Burnett
    Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK
    Nature 477:482-5. 2011
    ..Our findings do not rule out a role for sirtuins in determination of metazoan lifespan, but they do cast doubt on the robustness of the previously reported effects of sirtuins on lifespan in C. elegans and Drosophila...
  62. doi Aging alters tissue resident mesenchymal stem cell properties
    Eckhard U Alt
    Applied Stem Cell Laboratory, Heart and Vascular Institute, Department of Medicine, Tulane University Health Science Center, New Orleans, LA 70112, USA
    Stem Cell Res 8:215-25. 2012
    ..It has been long known that aging impedes an organism's repair/regeneration capabilities...
  63. pmc Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
    Colin Selman
    Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK
    Science 326:140-4. 2009
    Caloric restriction (CR) protects against aging and disease, but the mechanisms by which this affects mammalian life span are unclear...
  64. pmc Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains
    Vardhman K Rakyan
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK
    Genome Res 20:434-9. 2010
    There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here, we report the first genome-scale study of epigenomic dynamics during normal human aging...
  65. ncbi Cellular senescence: when bad things happen to good cells
    Judith Campisi
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, California 94720, USA
    Nat Rev Mol Cell Biol 8:729-40. 2007
    ....
  66. pmc Aging, cellular senescence, and cancer
    Judith Campisi
    Buck Institute for Research on Aging, Novato, California 94945, USA
    Annu Rev Physiol 75:685-705. 2013
    For most species, aging promotes a host of degenerative pathologies that are characterized by debilitating losses of tissue or cellular function...
  67. ncbi Rejuvenation of aged progenitor cells by exposure to a young systemic environment
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 433:760-4. 2005
    ..These results suggest that the age-related decline of progenitor cell activity can be modulated by systemic factors that change with age...
  68. pmc GABA regulates synaptic integration of newly generated neurons in the adult brain
    Shaoyu Ge
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 439:589-93. 2006
    ....
  69. pmc Aging, training, and the brain: a review and future directions
    Cindy Lustig
    Department of Psychology, University of Michigan, 530 Church Street, Ann Arbor, MI 48109 1043, USA
    Neuropsychol Rev 19:504-22. 2009
    ..Although many open questions remain, this research has greatly increased our understanding of how to promote successful aging of cognition and the brain.
  70. pmc The aging stress response
    Marcia C Haigis
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 40:333-44. 2010
    b>Aging is the outcome of a balance between damage and repair...
  71. pmc Mitochondrial DNA mutations in human disease
    Robert W Taylor
    Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, NE2 4HH, United Kingdom
    Nat Rev Genet 6:389-402. 2005
    ..However, many challenges remain, including the prevention and treatment of these diseases. This review explores the advances that have been made and the areas in which future progress is likely...
  72. pmc Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
    Darren J Baker
    Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Nature 479:232-6. 2011
    ..These data indicate that cellular senescence is causally implicated in generating age-related phenotypes and that removal of senescent cells can prevent or delay tissue dysfunction and extend healthspan...
  73. pmc SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress
    Hyun Seok Kim
    Genetics of Development and Disease Branch, NIDDK, NIH, Bethesda, MD 20892, USA
    Cancer Cell 17:41-52. 2010
    The sirtuin gene family (SIRT) is hypothesized to regulate the aging process and play a role in cellular repair...
  74. ncbi Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
    Rudolf Jaenisch
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Nat Genet 33:245-54. 2003
    ..The extent to which environmental effects can provoke epigenetic responses represents an exciting area of future research...
  75. pmc Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
    Guo Zhang
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nature 497:211-6. 2013
    ....
  76. ncbi Mutation of the mouse klotho gene leads to a syndrome resembling ageing
    M Kuro-O
    Division of Molecular Genetics, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Nature 390:45-51. 1997
    ..The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases...
  77. pmc A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine
    Douglas C Wallace
    Center for Molecular and Mitochondrial Medicine and Genetics, Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697 3940, USA
    Annu Rev Genet 39:359-407. 2005
    ..Therefore the mitochondria provide a direct link between our environment and our genes and the mtDNA variants that permitted our forbears to energetically adapt to their ancestral homes are influencing our health today...
  78. ncbi Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
    Claudio Franceschi
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Mech Ageing Dev 128:92-105. 2007
    A large part of the aging phenotype, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks, which results in the low grade chronic pro-inflammatory status we proposed to call ..
  79. pmc Genome-wide methylation profiles reveal quantitative views of human aging rates
    Gregory Hannum
    Department of Bioengineering, University of California, San Diego, San Diego, CA 92093, USA
    Mol Cell 49:359-67. 2013
    The ability to measure human aging from molecular profiles has practical implications in many fields, including disease prevention and treatment, forensics, and extension of life...
  80. ncbi Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain
    Susan M Resnick
    Laboratory of Personality and Cognition, National Institute on Aging, Baltimore, Maryland 21224 6825, USA
    J Neurosci 23:3295-301. 2003
    ..MRI) scans of 92 nondemented older adults (age 59-85 years at baseline) in the Baltimore Longitudinal Study of Aging to determine the rates and regional distribution of gray and white matter tissue loss in older adults...
  81. pmc Complement factor H polymorphism in age-related macular degeneration
    Robert J Klein
    Laboratory of Statistical Genetics, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 308:385-9. 2005
    ..This polymorphism is in a region of CFH that binds heparin and C-reactive protein. The CFH gene is located on chromosome 1 in a region repeatedly linked to AMD in family-based studies...
  82. pmc Exercise training increases size of hippocampus and improves memory
    Kirk I Erickson
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Proc Natl Acad Sci U S A 108:3017-22. 2011
    ..These theoretically important findings indicate that aerobic exercise training is effective at reversing hippocampal volume loss in late adulthood, which is accompanied by improved memory function...
  83. ncbi Extension of murine life span by overexpression of catalase targeted to mitochondria
    Samuel E Schriner
    Department of Genome Sciences, University of Washington, Seattle, WA 91895, USA
    Science 308:1909-11. 2005
    ..These results support the free radical theory of aging and reinforce the importance of mitochondria as a source of these radicals.
  84. pmc Linking functional decline of telomeres, mitochondria and stem cells during ageing
    Ergun Sahin
    Belfer Institute for Applied Cancer Science, Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 464:520-8. 2010
    ....
  85. ncbi TOR signaling in growth and metabolism
    Stephan Wullschleger
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Cell 124:471-84. 2006
    ..The physiological consequences of mammalian TORC1 dysregulation suggest that inhibitors of mammalian TOR may be useful in the treatment of cancer, cardiovascular disease, autoimmunity, and metabolic disorders...
  86. pmc The cell-non-autonomous nature of electron transport chain-mediated longevity
    Jenni Durieux
    The Glenn Center for Aging Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cell 144:79-91. 2011
    ..the mitochondria; however, the extent to which mitochondrial alteration in a single, distinct tissue may influence aging in the whole organism remains unknown...
  87. pmc Changes in primary lymphoid organs with aging
    Ivan K Chinn
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Semin Immunol 24:309-20. 2012
    b>Aging is associated with decreased immune function that leads to increased morbidity and mortality in the elderly...
  88. doi Genetics of longevity in model organisms: debates and paradigm shifts
    David Gems
    Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom
    Annu Rev Physiol 75:621-44. 2013
    Discovering the biological basis of aging is one of the greatest remaining challenges for science. Work on the biology of aging has discovered a range of interventions and pathways that control aging rate...
  89. pmc The role of mitochondria in aging
    Ana Bratic
    Department of Mitochondrial Biology, Max Planck Institute for Biology of Ageing, Cologne, Germany
    J Clin Invest 123:951-7. 2013
    ..evidence has suggested a causative link between mitochondrial dysfunction and major phenotypes associated with aging. Somatic mitochondrial DNA (mtDNA) mutations and respiratory chain dysfunction accompany normal aging, but the ..
  90. pmc Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH
    Akiko Satoh
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Metab 18:416-30. 2013
    ..However, the role of Sirt1 in the regulation of aging and longevity is still controversial...
  91. ncbi Mapping cortical change across the human life span
    Elizabeth R Sowell
    University of California at Los Angeles, Laboratory of Neuro Imaging, Department of Neurology, 710 Westwood Plaza, Los Angeles, California 90095, USA
    Nat Neurosci 6:309-15. 2003
    ..The trajectory of maturational and aging effects varied considerably over the cortex...
  92. ncbi The adolescent brain and age-related behavioral manifestations
    L P Spear
    Department of Psychology and Center for Developmental Psychobiology, Binghamton University, Binghamton, NY, USA
    Neurosci Biobehav Rev 24:417-63. 2000
    ..Developmental changes in these stressor-sensitive regions, which are critical for attributing incentive salience to drugs and other stimuli, likely contribute to the unique characteristics of adolescence...
  93. pmc Mitochondrial formation of reactive oxygen species
    Julio F Turrens
    Department of Biomedical Sciences, University of South Alabama, Mobile, AL 36688, USA
    J Physiol 552:335-44. 2003
    ..We also discuss various physiological and pathological scenarios resulting from an increased steady state concentration of mitochondrial oxidants...
  94. ncbi daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans
    S T Henderson
    Institute for Behavioral Genetics, University of Colorado at Boulder, Campus Box 447, Boulder, CO 80309 0447, USA
    Curr Biol 11:1975-80. 2001
    Evolutionary models of aging propose that a trade-off exists between the resources an organism devotes to reproduction and growth and those devoted to cellular maintenance and repair, such that an optimal life history always entails an ..
  95. ncbi Cellular senescence in cancer and aging
    Manuel Collado
    Spanish National Cancer Research Center CNIO, Madrid, Spain
    Cell 130:223-33. 2007
    ..Together these mechanisms limit excessive or aberrant cellular proliferation, and so the state of senescence protects against the development of cancer. Recent evidence suggests that cellular senescence also may be involved in aging.
  96. ncbi Aging: ROS or TOR
    Mikhail V Blagosklonny
    Ordway Research Institute, and Oncotarget, Albany, New York 12208, USA
    Cell Cycle 7:3344-54. 2008
    It is widely believed that aging is caused by the accumulation of random molecular damage due to reactive oxygen species (ROS). Here I discuss evidence for and against the ROS theory...
  97. pmc Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context
    Brock C Christensen
    Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA
    PLoS Genet 5:e1000602. 2009
    ..linked to cancers and many other human diseases, interindividual epigenetic variations in normal tissues due to aging, environmental factors, or innate susceptibility are poorly characterized...
  98. pmc Validation of anti-aging drugs by treating age-related diseases
    Mikhail V Blagosklonny
    Cancer Center, Ordway Research Institute, Albany, NY 12208, USA
    Aging (Albany NY) 1:281-8. 2009
    Humans die from age-related diseases, which are deadly manifestations of the aging process. In order to extend life span, an anti-aging drug must delay age-related diseases...
  99. ncbi Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a "set up" for vascular disease
    Edward G Lakatta
    Gerontology Research Center, Intramural Research Program, Gerontology Research Center, Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224 6825, USA
    Circulation 107:139-46. 2003
  100. ncbi Therapeutic potential of resveratrol: the in vivo evidence
    Joseph A Baur
    Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Rev Drug Discov 5:493-506. 2006
    ..Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans...
  101. ncbi Mitochondria: dynamic organelles in disease, aging, and development
    David C Chan
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 125:1241-52. 2006
    ..Clearly, much about the basic biology of mitochondria remains to be understood. Here we discuss recent work that suggests that the dynamics (fusion and fission) of these organelles is important in development and disease...

Research Grants91

  1. TRANSGENIC MICE, AGING, CANCER, AND OXIDATIVE DAMAGE
    Arlan Richardson; Fiscal Year: 2001
    The oxidative stress hypothesis of aging (or the free radical hypothesis as it was first proposed) is currently one the most popular explanations for how aging occurs at the biochemical level...
  2. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..Large cohorts of aging veterans also face degenerative diseases in which inflamatory pain is a major component...
  3. Lauren Endres; Fiscal Year: 2014
    ..If these mutations disrupt the function of key regulatory genes involved in cell growth and homeostasis, premature aging or cancer can occur...
  4. MERVYN N WEITZMANN; Fiscal Year: 2016
    ..of basal bone homeostasis in young mice and mitigate in part, the enhanced bone resorption associated with aging"...
  5. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..have higher mortality rates after myocardial infarction vs aged men, and it is unclear whether the effects of aging and estrogen (E2) deficiency are additive with regard to ethanol-induced cardiac ischemia/reperfusion (I/R) injury...
  6. KEVIN ROBERT VINCENT; Fiscal Year: 2014
    ..The primary mentor is Dr. Christiaan Leeuwenburgh, from the Department of Aging and Geriatrics. The Co-mentors are Drs. Scott banks and Steven Ghvizzani. Dr...
  7. Mechanisms of action of ghrelin in muscle and adipose tissue in cancer-related ca
    Jose M Garcia; Fiscal Year: 2013
    ..Cachexia is also a complication of many other conditions including lung and heart disease and aging, the knowledge generated through this proposal also will help us in establishing new therapies for these ..
  8. IMMUNOGENETICS OF COLLAGEN INDUCED ARTHRITIS IN MICE
    Chella David; Fiscal Year: 2009
    ..Smoking and aging can result in higher amounts of citrullination...
  9. Statin modulation of immunotherapy for Alzheimer disease
    Jun Tan; Fiscal Year: 2012
    ..Furthermore, as the aging population grows, AD will become an even greater socioeconomic problem...
  10. Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.
    Eduardo Rios; Fiscal Year: 2013
    ..Ca2+ signals deteriorate in disease, fatigue and aging. Fast Ca2+ signals fail in diseases like hypo-PP, MH susceptibility and central core and minicore, as well as in ..
  11. Kazem M Azadzoi; Fiscal Year: 2016
    ..We attempt to introduce the concept that aging-associated bladder ischemia is an independent factor in the development of non-obstructed non-neurogenic ..
  12. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..With increasing life expectancy and aging baby-boomer generation, the estimated future costs of treatment and elderly patient care, and its socio-economic ..
  13. Laura L Dugan; Fiscal Year: 2014
    ..We have further shown that Nox2 is induced and activated in neurons in the aging brain, and that Nox2 is in fact the major source of neuronal and synaptic superoxide production in aged mice...
  14. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ..reduction in cerebrovascular disease and stroke, preservation of vision, and slowing of cognitive decline during aging. Over the past several years, there has been a dramatic increase in the scientific scrutiny of omega-3 fatty acids ..
  15. CHIH CHANG KEVIN WEI; Fiscal Year: 2014
    ..The number of affected individuals is expected to rise significantly in our aging population over the next 30 years...
  16. Enzymatic Regulation of S-Glutathionylation : Role in Apoptosis and Disease
    John J Mieyal; Fiscal Year: 2012
    ..the effects of oxidative stress in neurodegenerative diseases, as well as in cardiovascular disease, diabetes and aging, all of which are prevalent among veterans...
  17. Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2010
    ..is the development, in early life, of specific epithelial and hematopoietic malignancies usually found only in aging populations...
  18. Sirtuin/FOXO Signaling in the Regulation of Bone Mass
    Stavroula Kousteni; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Bone homeostasis in the adult or aging skeleton, is perturbed by mechanisms that involve decreased defense against oxidative stress and/or increased production of Reactive Oxygen Species (ROS)...
  19. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
    ..risk of developing, at an early age, specific epithelial and hematopoietic malignancies usually found only in aging populations...
  20. Intracellular Phase Diagram Creation Using a Micro-Differential Scanning Calorime
    GARY L SOLBREKKEN; Fiscal Year: 2010
    ..An aging population is demanding such procedures for improving their quality of life...
  21. Weight Loss &Exercise Effects on Telomere Length in Postmenopausal Women
    ANNE M MCTIERNAN; Fiscal Year: 2012
    ..Progressive telomere shortening of somatic cells with successive cell division is a hallmark of cellular aging, with loss of ~ 50-100 base pairs per cell division...
  22. Drug Interactions at the Human Blood-Brain Barrier
    Jashvant D Unadkat; Fiscal Year: 2010
    ..facilitating tool development;05-AG-103* Imaging and Fluid Biomarkers for Early Diagnosis and Progression of Aging-related Diseases and Conditions including Neurodegenerative Diseases...
  23. Ken R Smith; Fiscal Year: 2015
    ..the Utah Population Database (UPDB) and links biomarker data collected from two studies: Fertility, Longevity &Aging study (FLAG) and the Cache County Memory Study (CCMS)...
  24. Sex Hormones in Postmenopausal Women in the Diabetes Prevention Program
    Catherine Kim; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Although postmenopause is a universal experience of aging and is defined by permanent changes in ovarian function, we still do not understand how postmenopausal sex hormones affect diabetes risk...
  25. Exome re-sequencing candidate loci for familial essential tremor
    Barry E Kosofsky; Fiscal Year: 2012
    ..experiments using in vitro and in vivo models will analyze the functional consequences of ET gene mutations during aging and development...
  26. Md Mizanur Rahman; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Aging is associated with increased inflammation and oxidative stress leading to progressive decline in musculoskeletal tissue mass, quality and function which increases the risk of falls and fractures ..
  27. Cornelia M Weyand; Fiscal Year: 2016
    ..Our studies have led to the discovery that patients with RA have premature aging of the immune system...
  28. Cellular and Animal Models of FUS Mutations in ALS
    Eric J Huang; Fiscal Year: 2013
    ..have profound impacts on many disciplines in biomedical research, including cancer biology, neurodegeneration, aging, and mental health...
  29. Margot S Damaser; Fiscal Year: 2014
    ..Since age, diabetes, and obesity are risk factors for FPFD, the aging US population and increasing prevalence of obesity and diabetes portend an FPFD epidemic in the U.S...
  30. Characterizing TLR Function of Human Dendritic Cells in the Elderly
    Alexander Panda; Fiscal Year: 2012
    ..faculty appointment, he will integrate his clinical and research training to pursue translational research on aging and innate immune responses in the lung, a decision supported by his mentors...
  31. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Project Narrative Heart failure is a very common disease of the aging population, with the highest incidence and prevalence in the age group above 65, which is also the largest Veteran ..
  32. The Somatotropic Axis and Health Aging: A Search for Mechanisms
    Andrzej Bartke; Fiscal Year: 2013
    ..of the proposed research is to identify mechanisms responsible for the effects of growth hormone (GH) signaling on aging and longevity in mammals...
  33. ROLE OF SIRTUIN IN CIGARETTE SMOKE-INDUCED LUNG INFLAMMATION AND INJURY
    Irfan Rahman; Fiscal Year: 2013
    ..COPD (emphysema and chronic bronchitis) is linked with premature aging (accelerated decline in lung function) and chronic inflammation of the lungs due to inhaled cigarette smoke-..
  34. PAUL CHRISTIAN SCHILLER; Fiscal Year: 2015
    ..Aim 3: Determine the role of progerin in the bone forming capacity of hMSCs in vivo. We expect that increased progerin expression in hMSCs will decrease their bone forming capacity in vivo. ..
  35. Ai Ling Lin; Fiscal Year: 2016
    ..structural and functional) integrity and its associations with cognitive function in animal models of healthy aging and of age-related neurodegenerative disorders...
  36. Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated Cardioprotecti
    DONNA HOPE KORZICK; Fiscal Year: 2012
    ..of our hypothesis will strongly support new targets for the treatment of acute coronary syndrome in the aging population and address the potential use of ER/PKC5 therapeutics as viable approaches to improve IT in post-..
  37. Krzysztof Palczewski; Fiscal Year: 2015
    ..application is organized around the five thematic (a) Retinal Development and Disease, (b) Phototransduction, (c) Aging and Diabetes in the Eye, (d) Ocular Inflammation and Infection, and (e) Translational Visual Sciences...
  38. Mark S Nanes; Fiscal Year: 2014
    ..prevents new bone formation, healing, and restoration of normal bone in inflammatory bone disorders, including RA, aging, and menopause...
  39. Patrick O'Connor; Fiscal Year: 2016
    ..research centers and institutes such as the Center for Interdisciplinary Research on AIDS and the Veterans Aging Cohort on HIV...
  40. Mechanism of Age-Related Change in Estrogen Receptor Beta Expression in Rat Brain
    JENNE MITCHELL WESTBERRY; Fiscal Year: 2012
    ..During aging, cognitive and neurodegenerative conditions increase...
  41. Epigenetic effects of developmental endocrine disruptor exposure in the ovary
    Mehmet Uzumcu; Fiscal Year: 2010
    ..causes reproductive dysfunction, such as early puberty, irregular cycles, reduced fertility, and premature aging. Preliminary studies also suggest that the MXC exposure cause morphological and gene expression alterations in ..
  42. Identifying all Meckel-like ciliopathy genes by established total exome capture a
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ..missense mutations cause a mild phenotype of tissue maintenance and repair and leads to degeneration and premature aging of organs (Senior-Loken syndrome), whereas truncating mutations cause severe developmental defects during ..
  43. Improved Adventitial Sirolimus Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The changing demographics of Western societies include an aging population with a near epidemic of obesity, insulin resistance, and diabetes mellitus, causing a dramatic rise in ..
  44. Pilot Studies of the Effect of Aging on Mucociliary Clearance
    Lawrence E Ostrowski; Fiscal Year: 2013
    ..Surprisingly, there have been no studies of the effect of aging on MCC in a mouse model...
  45. Epigenetic Analysis of iPS Cell Models of Aging and Alzheimer's Disease
    Bruce A Yankner; Fiscal Year: 2010
    ..Challenge Area (14) Stem Cells, and specific Challenge Topic, 14-AG-101: Induced Pluripotent Stem (iPS) Cells for Aging and Neurodegeneration Research...
  46. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2013
    ..Common clinical conditions, including aging, insulin resistance, diabetes and hypertension per se are associated with loss of this elastance function, ..
  47. UV-induced and NOS-mediated Zn elevation, translation regulation and apoptosis
    Shiyong Wu; Fiscal Year: 2012
    ..The outcomes from these studies will not only increase our knowledge of UV- induced multiple apoptotic signaling pathways, but will also lead us to the development of new therapeutics for treatment of UV-related skin aging and cancers.
  48. Undercarboxylated osteocalcin, body fat, and diabetes in older adults
    Ann V Schwartz; Fiscal Year: 2010
    ..in a population of older adults, this research project will use data and biological specimens from the Health, Aging and Body Composition (Health ABC) study, a cohort of 3,075 men and women, white and African-American, aged 70-79 ..
  49. NEURAL AND ENDOCRINE CONSEQUENCES OF PARITY
    ROBERT STAFFORD BRIDGES; Fiscal Year: 2012
    ..the hormonal regulation of anxiety within the context of the female's reproductive experience and how aging may interact with reproductive experience to affect anxiety...
  50. Effectivenss of a New Non-Invasive Erectile Support System in Aging Populations
    S ALEXANDER WEINSTOCK; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): As a normal consequence of aging, most men experience some form of erectile dysfunction (ED), which, in severe cases, causes impotence (the inability to sustain an erection sufficient to engage and ..
  51. Jingsong Zhou; Fiscal Year: 2014
    ..We anticipate that information obtained from our research will apply to other neuromuscular diseases, such as aging, diabetes, Parkinson's disease and others, where altered Ca signaling and intracellular oxidative stress are ..
  52. Henryk F Urbanski; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Aging results in a progressive decline in immune function, which leads to increased morbidity and mortality related to infections...
  53. Hematopoietic Stem Cells (HSCs) as Juvenile Protective Factors that Alter Aging
    David E Harrison; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Detrimental effects of aging might be due in part to loss of juvenile protective factors, including stem cells...
  54. Dopamine's Role in the Rapid Estradiol Enhancement of Excitatory Synapses
    CAROLINE COFER SMITH HAMILTON; Fiscal Year: 2013
    ..with E2 This project was extended to an aging model in which I showed that female rats which were hormone deprived for 19 months were unresponsive to E2 therapy ..
  55. Hypothalamic SIRT1 and Energy Balance
    Eduardo A Nillni; Fiscal Year: 2013
    ..deacetylase involved in many biological processes including cellular differentiation, apoptosis, metabolism, and aging. Because of its dependence on NAD+, Sirt1 also functions as a nutrient/redox sensor...
  56. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ARYAN MANGALAM NAMBOODIRI; Fiscal Year: 2013
    ..BBB) permeability of oximes and 2) resistance for reactivation of the CTA-inhibited AChE due to rapid 'aging'...
  57. Redox regulation of phagocyte NOX2 in inflammation and aging
    Robert A Clark; Fiscal Year: 2013
    ..that a related pathway exists for the phagocyte NADPH oxidase (NOX2) and that this pathway is dysregulated with aging, a biological process associated with ROS and oxidative stress...
  58. ANN NARDULLI; Fiscal Year: 2014
    ..A number of the proteins we identified are involved in responding to oxidative stress, which has been linked to aging and human disease. Oxidative stress proteins play pivotal roles in maintaining normal cell function...
  59. KATHERINE JULIA KELLY; Fiscal Year: 2014
    ..IL-1, angiotensin II or p38 MAPK will ameliorate renal injury in the postischemia inflammatory syndrome in the aging, diabetic kidney...
  60. Osteoclastic Protein-Tyrosine Phosphatase and Resorption
    Kin Hing William Lau; Fiscal Year: 2013
    ..and effective therapies to overcome and/or even prevent osteoporosis would significantly reduce the morbidity with aging and improve the quality of life...
  61. B Cell Development in Aging
    John C Cambier; Fiscal Year: 2010
    b>Aging is associated with decreased efficacy of vaccination, and increased morbidity and mortality following infection by agents such as pneumococcus, influenza and West Nile virus...
  62. Imbalances in Calcium Homeostasis: Mechanism Behind Ethanol-Related Dendritic Deg
    Cynthia A Dlugos; Fiscal Year: 2010
    ..This is a major health concern as the aging population continues to escalate...
  63. Heat Shock Effects on Human Mesenchymal Stem Cell Differentiation in Hydrogel
    Sihong Wang; Fiscal Year: 2010
    ..field of regenerative medicine, holds promise for the restoration of tissues and organs damaged by diseases, aging, and trauma...
  64. CLIFFORD JAMES ROSEN; Fiscal Year: 2015
    ..In addition, aging also profoundly affects adipose tissue through atrophy of preformed brown adipose tissue (BAT), lipid deposition ..
  65. DNA methylation in aging, race and prostate cancer
    Rajvir Dahiya; Fiscal Year: 2006
    The main goal of this proposal is to identify and characterize the epigenetic alterations that are involved in aging and race-related prostate cancer...
  66. Molecular mechanisms of oxidative stress resistance in an animal model of aging w
    Sarah Milton; Fiscal Year: 2009
    ..and oxidative stress on protein organization, cellular homeostasis, and apoptosis are recognized as key factors in aging and senescence, and ROS damage is thought to play a role in a number of neurodegenerative diseases including ..
  67. DAWN L KONRAD-MARTIN; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Project Summary/Abstract A hallmark of aging is difficulty understanding speech spoken rapidly or in noisy or reverberant conditions...
  68. Health and Retirement Survey for India
    David Bloom; Fiscal Year: 2009
    ..The long-term goals of this research are (a) to develop a nationally representative, longitudinal survey of aging, health, and retirement in India;(b) to provide the foundation for new, rigorous, multidisciplinary studies of ..
  69. Intimate Partner Violence in Rural Aging Women: Promoting Community Knowledge
    KAREN ROBERTO; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Intimate Partner Violence in Rural Aging Women: Promoting Community Knowledge Intimate partner violence (IPV), which includes physical, sexual, or psychological abuse, is a major public health ..
  70. PRF 10th Anniversary Workshop on Progeria - "From Bench to Bedside in a Decade"
    Leslie B Gordon; Fiscal Year: 2010
    ..Hutchinson-Gilford progeria syndrome (Progeria or HGPS) is a rare, autosomal dominant segmental premature-aging disease in which 100% of children die at an average age of thirteen years due to strokes or heart attacks, a ..
  71. Oxidative stress drives ovarian aging: modification by genetics and environment
    Ulrike Luderer; Fiscal Year: 2009
    ..It is therefore important to understand the factors that contribute to normal and accelerated ovarian aging so that we can prevent early menopause and its adverse consequences...
  72. EFFECTS OF AGING ON GERMLINE AND SOMATIC STEM CELLS IN DROSOPHILA MELANOGASTER
    MATTHEW WALLENFANG; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The process of aging is fundamental to virtually all multicellular organisms...
  73. DNA Interstrand Crosslinks, Cancer and Aging
    Laura Niedernhofer; Fiscal Year: 2007
    ..Repair deficiency in humans can lead to a profound risk of cancer or dramatic premature aging. Prevention of cancer and age-related morbidity are therefore dependent upon identifying the sources of DNA damage ..
  74. Aging and Heart Failure are not Similar Syndromes of Sympathetic Dysregulation
    MICHAEL KENNEY; Fiscal Year: 2009
    ..diagnosis and treatment of heart failure (HF), the incidence of this disorder is increasing, primarily due to the aging of the population...
  75. Comparative effectiveness in older cancer patients: age versus health status
    LINDA KROGH HAROOTYAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): "Three comparative effectiveness sessions focused on aging and cancer, 90 minutes each, will be incorporated into the 2010 Annual Scientific Meeting of the Gerontological Society of America that will ..
  76. Neurodegeneration in Aging Retarded Mice
    Roger Albin; Fiscal Year: 2009
    ..provided by applicant): Neurodegenerative disorders, both sporadic and inherited, are associated commonly with aging. The wide variety of likely mechanisms of action in different neurodegenerative disorders suggests that common ..
  77. 2009 Oxidative Stress and Disease Gordon Research Conference
    Holly Van Remmen; Fiscal Year: 2009
    ..The underlying focus for this particular conference is the role of oxidative stress in aging and age-related disease...
  78. Chronic and Acute Psychosocial Stress and Impaired Cell Aging
    Elissa Epel; Fiscal Year: 2009
    PROJECT SUMMARY/ABSTRACT Understanding factors influencing the aging process is central to reducing morbidity, an increasingly important goal in light of our rapidly aging population...
  79. UCLA-Drew/City of Los Angeles Area Agency on Aging Center for Community Research
    CATHERINE A contact SARKISIAN; Fiscal Year: 2010
    ..our UCLA-Drew scientists have worked in partnership with the leadership at the City of Los Angeles Department of Aging on community-based projects aimed at improving the health and quality of life of lower income older adults...
  80. Sensing Protein Folding Capacity in the Cell During Aging
    ROCKLAND L WISEMAN; Fiscal Year: 2010
    ..This GO grant addresses the critical need for development of biosensors that detect protein dysfunction during aging. The long-term health of all cells is inextricably linked to protein folding and sustainability of function...
  81. Rehabilitation Research & Training Center on Aging with Development Disabilities
    Tamar Heller; Fiscal Year: 2007
    unreadable] DESCRIPTION (Provided by Applicant): The conference "State of the Science in Aging with Developmental Disabilities: Charting Lifespan Trajectories and Supportive Environments for Healthy Community Living" is sponsored by ..
  82. Harmonization of Aging Surveys & Cross-National Comparat
    Jinkook Lee; Fiscal Year: 2006
    ..DESCRIPTION (provided by applicant): A great deal of harmonization efforts have occurred among the existing aging data sets; however, the comparability of these aging surveys has not been fully articulated, calling for more ..
  83. IMMUNOBIOLOGY OF AGING
    CHARLES GARRISON FATHMAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The immune system is profoundly affected by aging. Older individuals are at higher risk of death and disability from infections and cancer...
  84. Mechanism of Nuclear Defects in Hutchinson-Gilford Progeria Syndrome
    Yue Zou; Fiscal Year: 2009
    ..of DNA double strand breaks (DSBs) has been widely suggested to be a hallmark step leading to premature aging, cellular senescence, and aging...
  85. Caloric Restriction and Aging in Humans
    John Holloszy; Fiscal Year: 2009
    DESCRIPTION: (provided by applicant) Primary aging is the progressive deterioration in structure and function with advancing age that occurs independently of disease and lifestyle/environmental factors...