growth and development

Summary

Summary: The series of changes to the shape, size, components, and functions of an individual organism that occur over time as the organism progresses from its initial form to full size and maturity.

Top Publications

  1. ncbi Early and late weight gain and the timing of puberty
    David B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Cambridge CB2 2QQ, UK
    Mol Cell Endocrinol 254:140-5. 2006
  2. pmc Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development
    Ulla Sovio
    Department of Epidemiology and Biostatistics, Imperial College, London, United Kingdom
    PLoS Genet 7:e1001307. 2011
  3. ncbi CSF-1, IGF-1, and the control of postnatal growth and development
    Deborah J Gow
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian EH25 9PS, UK
    J Leukoc Biol 88:475-81. 2010
  4. ncbi Effects of pollution on human growth and development: an introduction
    Lawrence M Schell
    University at Albany, Albany, NY 12222, USA
    J Physiol Anthropol 25:103-12. 2006
  5. pmc Effects of low-dose drinking water arsenic on mouse fetal and postnatal growth and development
    Courtney D Kozul-Horvath
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire, United States of America
    PLoS ONE 7:e38249. 2012
  6. pmc Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development
    Wilhelm Stoffel
    Laboratory of Molecular Neurosciences, Center of Molecular Medicine, Center of Biochemistry, Faculty of Medicine, University of Cologne, D 50931 Cologne, Germany
    Proc Natl Acad Sci U S A 102:4554-9. 2005
  7. ncbi Ghrelin and the growth hormone secretagogue receptor in growth and development
    J P Chanoine
    Endocrinology and Diabetes Unit, Department of Pediatrics, British Columbia s Children s Hospital, University of British Columbia, 4480 Oak Street, Vancouver, British Columbia, Canada
    Int J Obes (Lond) 33:S48-52. 2009
  8. ncbi Adolescent growth spurts in female gymnasts
    Martine Thomis
    Department of Sport and Movement Sciences, Faculty of Kinesiology and Rehabilitation Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
    J Pediatr 146:239-44. 2005
  9. ncbi Patterns of growth associated with the timing of adiposity rebound
    Sheila M Williams
    Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Obesity (Silver Spring) 17:335-41. 2009
  10. ncbi Functional mapping of growth and development
    Yao Li
    Department of Statistics, University of Florida, Gainesville, 32611, USA
    Biol Rev Camb Philos Soc 85:207-16. 2010

Detail Information

Publications272 found, 100 shown here

  1. ncbi Early and late weight gain and the timing of puberty
    David B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Cambridge CB2 2QQ, UK
    Mol Cell Endocrinol 254:140-5. 2006
    ..of puberty is most closely linked to infancy weight gain: suggesting an early window for programming of growth and development. Earlier puberty in the UK MRC 1946 birth cohort was related to smaller size at birth and rapid growth ..
  2. pmc Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development
    Ulla Sovio
    Department of Epidemiology and Biostatistics, Imperial College, London, United Kingdom
    PLoS Genet 7:e1001307. 2011
    ..The associated shifts in developmental timing have clinical importance with respect to known relationships between AR and both later-life BMI and metabolic disease risk...
  3. ncbi CSF-1, IGF-1, and the control of postnatal growth and development
    Deborah J Gow
    The Roslin Institute and Royal Dick School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian EH25 9PS, UK
    J Leukoc Biol 88:475-81. 2010
    ..Accordingly, CSF-1 may be considered a part of the GH/IGF-1 axis...
  4. ncbi Effects of pollution on human growth and development: an introduction
    Lawrence M Schell
    University at Albany, Albany, NY 12222, USA
    J Physiol Anthropol 25:103-12. 2006
    ..Studies of human growth and development in relation to pollution have increased in number and quality since the mid-twentieth century...
  5. pmc Effects of low-dose drinking water arsenic on mouse fetal and postnatal growth and development
    Courtney D Kozul-Horvath
    Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, New Hampshire, United States of America
    PLoS ONE 7:e38249. 2012
    ..The goal of this study was to identify adverse outcomes in a mouse model of early life exposure to low-dose drinking water As (10 ppb, current U.S. EPA Maximum Contaminant Level)...
  6. pmc Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development
    Wilhelm Stoffel
    Laboratory of Molecular Neurosciences, Center of Molecular Medicine, Center of Biochemistry, Faculty of Medicine, University of Cologne, D 50931 Cologne, Germany
    Proc Natl Acad Sci U S A 102:4554-9. 2005
    ..The smpd3(-/-) mouse might mimic a form of human combined pituitary hormone deficiency...
  7. ncbi Ghrelin and the growth hormone secretagogue receptor in growth and development
    J P Chanoine
    Endocrinology and Diabetes Unit, Department of Pediatrics, British Columbia s Children s Hospital, University of British Columbia, 4480 Oak Street, Vancouver, British Columbia, Canada
    Int J Obes (Lond) 33:S48-52. 2009
    ..These data point toward a physiological role for ghrelin and GHSR in growth and/or in the maturation of hormonal systems involved in the regulation of energy balance...
  8. ncbi Adolescent growth spurts in female gymnasts
    Martine Thomis
    Department of Sport and Movement Sciences, Faculty of Kinesiology and Rehabilitation Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
    J Pediatr 146:239-44. 2005
    ..adolescent growth spurts in height, sitting height, and leg length? (2) Are the sequence and magnitude of spurts comparable with female adolescent non-athletes? (3) How do the data compare with other female gymnasts and with short girls?..
  9. ncbi Patterns of growth associated with the timing of adiposity rebound
    Sheila M Williams
    Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Obesity (Silver Spring) 17:335-41. 2009
    ..12 (95% CI: 1.09, 4.13) and 3.32 (95% CI: 1.46, 7.54). Thus, early rebound is associated with increased depositions of fat in middle childhood, and risks associated with early rebound persist at least until early adulthood...
  10. ncbi Functional mapping of growth and development
    Yao Li
    Department of Statistics, University of Florida, Gainesville, 32611, USA
    Biol Rev Camb Philos Soc 85:207-16. 2010
    ....
  11. pmc ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice
    Chun Chen
    Lung Biology Center, University of California San Francisco, Box 2922, San Francisco, CA 94143 2922, USA
    Mol Cell Biol 26:6950-6. 2006
    ..Our results demonstrate that ADAM33 is not essential for growth or reproduction in the mouse and does not modulate baseline or allergen-induced airway responsiveness...
  12. ncbi II. Model building: an electrical theory of control of growth and development in animals, prompted by studies of exogenous magnetic field effects (paper I), and evidence of DNA current conduction, in vitro
    Edward Elson
    Department of Electrical and Computer Engineering, University of Maryland, College Park, MD, USA
    Electromagn Biol Med 28:283-309. 2009
    ..a "sub-microscopic level," at the level of the chromosomes themselves, and could play a role in organizing and directing fundamental processes of growth and development, in parallel with the more discernible fields and currents described.
  13. pmc Nuclear receptor coactivator/coregulator NCoA6(NRC) is a pleiotropic coregulator involved in transcription, cell survival, growth and development
    Muktar A Mahajan
    Department of Pharmacology, NYU School of Medicine, New York, New York, USA
    Nucl Recept Signal 6:e002. 2008
    ..Studies with NCoA6+/- and conditional knockout mice suggest that NCoA6 is a pleiotropic coregulator involved in growth, development, wound healing and maintenance of energy homeostasis...
  14. ncbi Concurrent growth of phenotypic features: a phenomenological universalities approach
    L Barberis
    FaMAF, Universidad Nacional de Cordoba, Medina Allende s n, Ciudad Universitaria, 5000 Cordoba, Argentina
    J Theor Biol 264:123-9. 2010
    ..We then apply the procedure to two biological systems in order to show how to determine the existence of mutual interference between trait variations...
  15. ncbi Growth of Chinese Italian infants in the first 2 years of life
    S Toselli
    Dipartimento di Biologia Evoluzionistica Sperimentale Università degli Studi di Bologna Italy
    Ann Hum Biol 32:15-29. 2005
    ..Numerous studies have been carried out on the growth of human migrant populations. However, studies on the auxological pattern of Chinese migrant population are limited in Italy...
  16. pmc Sex differences in the effect of prepubertal GALP infusion on growth, metabolism and LH secretion
    N Rich
    Biology Department, Hope College, 35 East 12th Street, Schaap Science Center 3065, Holland, MI 49423, United States
    Physiol Behav 92:814-23. 2007
    ..These data suggest that GALP may be involved with the prepubertal increase in circulating leptin, LH, and GH resulting in an increase in metabolic rate and lean growth associated with puberty...
  17. ncbi A longitudinal study of growth patterns in schoolchildren in one Taipei District. II: Sitting height, arm span, body mass index and skinfold thickness
    Tian Shing Lee
    Department of Pediatrics, Taipei Veterans General Hospital, Taiwan, ROC
    J Chin Med Assoc 68:16-20. 2005
    ....
  18. ncbi [Somatic development of seven-year-old Silesian children in view of environment pollution]
    Onufry Torbus
    I Katedry Pediatrii i Kliniki Gastroenterologii, Alergologii i Zaburzefi Rozwoju Wieku Dzieciecego w Zabrzu
    Wiad Lek 55:942-9. 2002
    ..The weight and height of seven-year-old children, especially boys, seems to be a good/sensitive indicator of the influence of environmental conditions on children's development...
  19. ncbi Italian cross-sectional growth charts for height, weight and BMI (2 to 20 yr)
    E Cacciari
    Department of Pediatrics, University of Bologna, Bologna, Italy
    J Endocrinol Invest 29:581-93. 2006
    ..SIEDP-2006 references intend to supply pediatricians with a tool that avoids the use of charts that are outdated or that refer to other populations, and thus should be suitable for adequately monitoring the growth of their patients...
  20. ncbi Weight and growth requirements for menarche in teenage girls with eating disorders, weight loss and primary amenorrhea
    Ingemar Swenne
    Department of Women s and Children s Health, Uppsala University, Uppsala, Sweden
    Horm Res 69:146-51. 2008
    ..To investigate weight and growth requirements for menarche in girls with eating disorders (ED), weight loss and primary amenorrhea...
  21. ncbi An oral two-generation reproductive toxicity study of S-111-S-WB in rats
    Donald G Stump
    WIL Research Laboratories, LLC, 1407 George Road, Ashland, OH 44805, USA
    Reprod Toxicol 25:7-20. 2008
    ..025mg/(kgday) was considered to be the NOAEL for neonatal toxicity based on higher liver weights in the F(1) and F(2) pups at 0.125mg/(kgday) and higher...
  22. ncbi The murine stanniocalcin 2 gene is a negative regulator of postnatal growth
    Andy C M Chang
    Cancer Research Unit, The Children s Hospital, Westmead, New South Wales 2145, Australia
    Endocrinology 149:2403-10. 2008
    ..This effect was not mediated through the GH/IGF-I axis. The results are consistent with STC2 being a negative regulator of postnatal growth...
  23. ncbi The effect of rainfall during gestation and early childhood on adult height in a foraging and horticultural society of the Bolivian Amazon
    Ricardo Godoy
    Heller School for Social Policy and Management, Brandeis University, Waltham, Massachusetts 02454, USA
    Am J Hum Biol 20:23-34. 2008
    ..2% lower adult height (1.08-1.93 cm). Environmental perturbations that take place after the cessation of weaning seem to leave the strongest effect on adult height. We advance possible explanations for the absence of effects among males...
  24. ncbi Catch-up reproductive maturation in rural Tonga girls, Zambia?
    Rhonda Gillett-Netting
    Department of Anthropology University of Arizona, Tucson, Arizona 85721 0030, USA
    Am J Hum Biol 16:658-69. 2004
    ..While the mechanism remains unclear, biocultural explanations suggest preferential feeding during adolescence as a source for rural girl's maturational catch-up...
  25. ncbi NTP-CERHR Expert Panel Report on the reproductive and developmental toxicity of amphetamine and methamphetamine
    Mari Golub
    California Environment Protection Agency, Sacramento, CA, USA
    Birth Defects Res B Dev Reprod Toxicol 74:471-584. 2005
  26. ncbi Measurement and standardization protocols for anthropometry used in the construction of a new international growth reference
    Mercedes de Onis
    Department of Nutrition, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland
    Food Nutr Bull 25:S27-36. 2004
    ..Ongoing central and local monitoring identified anthropometrists deviating from standard procedures, and immediate corrective action was taken. The procedures described in this paper are a model for research settings...
  27. ncbi Rationale for developing a new international growth reference
    Cutberto Garza
    United Nations University and Cornell University, Ithaca, New York, USA
    Food Nutr Bull 25:S5-14. 2004
    ....
  28. ncbi Implementation of the WHO Multicentre Growth Reference Study in Norway
    Anne Baerug
    National Breastfeeding Centre, Rikshospitalet University Hospital, Oslo, Norway
    Food Nutr Bull 25:S72-7. 2004
    ..One of the major challenges of the study was to achieve an acceptable participation rate; great efforts were made to motivate pregnant women via the health care system and the media...
  29. ncbi Implementation of the WHO Multicentre Growth Reference Study in Brazil
    Cora L Araujo
    Departamento de Nutricao, Universidade Federal de Pelotas, Brazil
    Food Nutr Bull 25:S53-9. 2004
    ....
  30. ncbi Implementation of the WHO Multicentre Growth Reference Study in Oman
    Nitya S Prakash
    Food Nutr Bull 25:S78-83. 2004
    ..These and other challenges were overcome through specific team building and public relations activities that permitted the successful implementation of the MGRS protocol...
  31. ncbi Implementation of the WHO Multicentre Growth Reference Study in India
    Nita Bhandari
    Department of Pediatrics, All India Institute of Medical Sciences, New Delhi
    Food Nutr Bull 25:S66-71. 2004
    ....
  32. ncbi Implementation of the WHO Multicentre Growth Reference Study in the United States
    Kathryn G Dewey
    Department of Nutrition, University of California, Davis, California, USA
    Food Nutr Bull 25:S84-9. 2004
    ..The cross-sectional sample was recruited between January and July 2001. Major challenges during implementation were maintaining daily communication with hospital personnel and scheduling home visits...
  33. ncbi Implementation of the WHO Multicentre Growth Reference Study in Ghana
    Anna Lartey
    Department of Nutrition and Food Science, University of Ghana, Legon
    Food Nutr Bull 25:S60-5. 2004
    ..Conversely, the high rates of breastfeeding and general support for this practice greatly facilitated the implementation of the MGRS protocol...
  34. ncbi Managing data for a multicountry longitudinal study: experience from the WHO Multicentre Growth Reference Study
    Adelheid W Onyango
    Department of Nutrition, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland
    Food Nutr Bull 25:S46-52. 2004
    ..Through the rigorous implementation of what has been a highly demanding protocol, the MGRS has accumulated a large body of very high-quality data...
  35. ncbi Agrarian reforms, agrarian crisis and the biological standard of living in Poland, 1844-1892
    Michał Kopczyński
    Department of History, University of Warsaw, ul Krakowskie Przedmiescie 26 28, 00 927 Warsaw, Poland
    Econ Hum Biol 5:458-70. 2007
    ..The persistence of the trend in the 1880s was due to the development of animal husbandry after the closure of the border against imported cattle in 1882 and the more balanced pattern of modernization than in the Kingdom of Poland...
  36. ncbi A retrospective analysis of the two-generation study: what is the added value of the second generation?
    Gemma Janer
    National Institute of Public Health and the Environment RIVM, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Reprod Toxicol 24:97-102. 2007
    ..These results support the proposal of replacing the current two-generation study by a one-generation study with a more extensive assessment of parameters at F(1) adulthood...
  37. ncbi Chronic treatment of male tammar wallabies with deslorelin implants during pouch life: effects on development, puberty, and reproduction in adulthood
    C A Herbert
    School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia
    Biol Reprod 76:1054-61. 2007
    ....
  38. ncbi Effects of Lantana camara (Verbenaceae) on general reproductive performance and teratology in rats
    Fernanda B Mello
    Departamento de Farmacologia, Instituto de Ciências Básicas da Saúde ICBS, Universidade Federal do Rio Grande do Sul, UFRGS, Av Sarmento Leite n 500, sala 202, Porto Alegre, RS, 90046 900, Brazil
    Toxicon 45:459-66. 2005
    ..The other parameters evaluated did not suggest modifications...
  39. ncbi Effect of microbial phytase addition with or without the trace mineral premix in nursery, growing, and finishing pig diets
    J L Shelton
    Department of Animal Sciences, Louisiana State University Agricultural Center, Baton Rouge 70803 4210, USA
    J Anim Sci 83:376-85. 2005
    ..These data indicate that removing the TMP in diets for nursery pigs decreases growth performance and bone mineral content, and that phytase addition to the diet without the TMP prevented the decreased growth performance...
  40. ncbi Small intestinal morphometric and biomechanical changes during physiological growth in rats
    Xiao Lu
    Center of Excellence in Visceral Biomechanics and Pain, Aalborg Hospital and Center of Sensory Motor Interaction, Aalborg University, Hobrovej 18 22, Aalborg DK 9100, Denmark
    J Biomech 38:417-26. 2005
    ..Such data may prove useful in the understanding of the functional changes of the digestive tract during early life...
  41. ncbi Physical activity and healthy weight maintenance from childhood to adulthood
    Verity J Cleland
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Obesity (Silver Spring) 16:1427-33. 2008
    ..Examining personal, social, and environmental factors associated with healthy weight maintenance will be an important next step in understanding why some groups avoid becoming overweight...
  42. ncbi The administration of oleoyl-estrone to lactating dams induces selective changes in the normal growth pattern of their pups
    B García-Peláez
    Departament de Nutrició i Bromatologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Horm Metab Res 39:582-8. 2007
    ..Thus, treatment affects dams in a selective way that does not coincide with a simple food restriction model...
  43. ncbi Bone mineral and predictors of bone mass in white, Hispanic, and Asian early pubertal girls
    C M Weaver
    Department of Foods and Nutrition, Purdue University, 700 W State Street, West Lafayette, IN 47907 2059, USA
    Calcif Tissue Int 81:352-63. 2007
    ..Bone size explained most of the racial/ethnic differences in BMC, although behavioral indicators were also significant predictors of BMC...
  44. ncbi Impact of long-term iron chelation therapy on growth and endocrine functions in thalassaemia
    Vincenzo De Sanctis
    Department of Reproduction and Growth, Paediatric and Adolescent Unit, S Anna Hospital, Ferrara, Italy
    J Pediatr Endocrinol Metab 19:471-80. 2006
    ..In conclusion, our study noted a positive effect of DFX therapy on sexual maturation and endocrine complications. Nevertheless, short stature has persisted despite major advances in treatment...
  45. ncbi Childcare, height and BMI among female Polish university students, 2005
    Iwona Wronka
    Department of Anthropology, Jagiellonian University, ul Ingardena 6, 30 060 Krakow, Poland
    Econ Hum Biol 5:435-42. 2007
    ..Adult BMI values are influenced by educational level of the mother. The results suggest that mothers who work often do so at the cost of time devoted to the family which influences health and the rate of their children's development...
  46. ncbi Efficacy of a monthly compared to 3-monthly depot GnRH analogue (goserelin) in the treatment of children with central precocious puberty
    H Isaac
    Department of Paediatric Endocrinology, Royal Manchester Children s Hospital, Manchester, UK
    Horm Res 68:157-63. 2007
    ..To compare the efficacy of goserelin 10.8 mg (Zoladex LA-ZLA) administered 9-12 weekly with 3.6 mg (Zoladex-Z) given monthly in suppressing pubertal development, and effect on body mass index (BMI)...
  47. pmc The muscle--fat duel or why obese children are taller?
    Dina Ralt
    Izun and Tmura, Integrative Health Inst, 6 Nezach Israel st, Tel Aviv, 64352, Israel
    BMC Pediatr 6:33. 2006
    ..Obesity the epidemic of our times appears to be a problem that is easy to resolve: just eat less and move more. However, this very common condition has turned out to be extremely troublesome, and in some cases even irreversible...
  48. ncbi NTP-CERHR Expert Panel Update on the Reproductive and Developmental Toxicity of di(2-ethylhexyl) phthalate
    Robert Kavlock
    US Environmental Agency, Research Triangle Park, NC, USA
    Reprod Toxicol 22:291-399. 2006
  49. ncbi Estimating final height from parental heights and sex in Taiwanese
    Pen Hua Su
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
    Hum Biol 79:283-92. 2007
    ....
  50. ncbi Development of ecological competence in Sumatran orangutans
    Maria A van Noordwijk
    Department of Biological Anthropology and Anatomy, Duke University, Durham, North Carolina 27708, USA
    Am J Phys Anthropol 127:79-94. 2005
    ..Thus, the exceptionally long interbirth intervals of orangutans may be a consequence of their solitary lifestyle...
  51. ncbi Developmental programming: differential effects of prenatal exposure to bisphenol-A or methoxychlor on reproductive function
    Mozhgan Savabieasfahani
    Department of Pediatrics, 300 North Ingalls Building, Room 1109 SW, Ann Arbor, University of Michigan 48109 0404, USA
    Endocrinology 147:5956-66. 2006
    ..05) in BPA sheep. These findings suggest that prenatal BPA and MXC exposure have long-term differential effects on a variety of reproductive endocrine parameters that could impact fertility...
  52. ncbi Socioeconomic position at different stages of the life course and its influence on body weight and weight gain in adulthood: a longitudinal study with 13-year follow-up
    Katrina Giskes
    Department of Public Health, Erasmus Medical Centre, Rotterdam, The Netherlands
    Obesity (Silver Spring) 16:1377-81. 2008
    ..Importantly, these etiologically relevant periods differ for men and women, suggesting gender-specific pathways to socioeconomic inequalities in body weight in adulthood...
  53. ncbi Myocardial substrates in children with congenital heart disease: relationship to substrate supply, age, growth and desaturation
    Kerstin Amark
    Department of Pediatrics, The Queen Silvia Children s Hospital, Goteborg University, Goteborg, Sweden
    Acta Paediatr 96:1677-80. 2007
    ..The purpose of this study was to define myocardial substrate uptake in relation to the arterial supply of substrates, age, growth and oxygen saturation...
  54. ncbi Asthma/allergic airways disease: does postnatal exposure to environmental toxicants promote airway pathobiology?
    Charles G Plopper
    Department of Anatomy, Physiology, and Cell Biology, University of California, Davis, CA 95616, USA
    Toxicol Pathol 35:97-110. 2007
    ....
  55. ncbi Balance in healthy individuals assessed with Equitest: maturation and normative data for children and young adults
    C Ferber-Viart
    Explorations Audiologiques et Orofaciales, Centre Hospitalier Lyon Sud, 69310 Pierre Benite, France
    Int J Pediatr Otorhinolaryngol 71:1041-6. 2007
    ..The purpose of the present prospective study was to obtain normative data for Equitest computerized dynamic posturography (CDP) in children and young adults and to observe the balance maturation process...
  56. pmc V(D)J recombinase-mediated processing of coding junctions at cryptic recombination signal sequences in peripheral T cells during human development
    Janet M Murray
    Department of Pediatrics, University of Vermont, Burlington, VT 05405, USA
    J Immunol 177:5393-404. 2006
    ....
  57. ncbi Trisomy 14 Mosaicism: a case without evidence of neurodevelopmental delay and a review of the literature
    T Allen Merritt
    Department of Pediatrics, Neonatology, Loma Linda University Children s Hospital, Loma Linda, California, USA
    Am J Perinatol 24:563-6. 2007
    ..This child did not demonstrate neurodevelopmental delay, which as been reported universally among children with trisomy 14 mosaicism...
  58. ncbi Growth charts for use in Australia
    Peter S W Davies
    OZGROW Research Team, Children s Nutrition Research Centre, Discipline of Paediatrics and Child Health, University of Queensland, Royal Children s Hospital, Herston, Queensland, Australia
    J Paediatr Child Health 43:4-5. 2007
    ..Height velocity for age and other charts remain unchanged...
  59. ncbi Body mass index reference values (mean and SD) for Japanese children
    Mikako Inokuchi
    Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan
    Acta Paediatr 96:1674-6. 2007
    ..CONCLUSIONS: The BMI-SD reference values and charts presented have appropriately reflected the age-dependent skewed distribution of BMI values, and could be a useful tool in growth and nutritional evaluation of Japanese children...
  60. ncbi Morphological age-dependent development of the human carotid bifurcation
    Jaehoon Seong
    Department of Biomedical Engineering, University of Miami, College of Engineering, 1251 Memorial Drive, Coral Gables, FL 33146, USA
    J Biomech 38:453-65. 2005
    ..A larger database will enable in the future a more extensive analysis such as gender or racial differences...
  61. ncbi Distribution of murine adipose-derived mesenchymal stem cells in vivo following transplantation in developing mice
    Xinbo Liao
    Pennsylvania State University College of Medicine, Department of Orthopaedics and Rehabilitation, Division of Musculoskeletal Sciences, Hershey PA 17033, USA
    Stem Cells Dev 17:303-14. 2008
    ..These data suggest that exposure of ADSCs to bone microenvironment or to TGF-beta1 prior to transplantation enhances their survival in the skeletal tissues following transplantation...
  62. ncbi Secular changes in the physical development of students of the Medical University of Łódź
    A Sitek
    School of Anthropology, University of Lodz, Łódź, Poland
    Folia Morphol (Warsz) 66:62-8. 2007
    ....
  63. ncbi A bioavailability model predicting the toxicity of nickel to rainbow trout (Oncorhynchus mykiss) and fathead minnow (Pimephales promelas) in synthetic and natural waters
    Nele M E Deleebeeck
    Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Jozef Plateaustraat 22, B 9000 Ghent, Belgium
    Ecotoxicol Environ Saf 67:1-13. 2007
    ..Although the developed model seems very promising, the uncertainty around the role of alkalinity and the exact mechanisms by which Ca, Mg and pH modify Ni toxicity need to be further explored...
  64. ncbi The expression of insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) genes in the human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface
    V K Han
    Department of Pediatrics, Lawson Research Institute, University of Western Ontario, London, Canada
    J Clin Endocrinol Metab 81:2680-93. 1996
    ..insulin-like growth factors (IGFs) and their binding proteins (IGFBPs), which are believed to regulate its growth and development in an autocrine/paracrine manner...
  65. ncbi Flutamide decreases cortisol clearance in patients with congenital adrenal hyperplasia
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development NIH, 10 Center Drive, Building 10 Suite 9D42, Bethesda, MD 20892, USA
    J Clin Endocrinol Metab 87:3197-200. 2002
    ..testolactone, reduced hydrocortisone dose, and 9alpha-fludrocortisone has been shown to achieve normal growth and development after 2 yr of therapy and may, therefore, represent a potential alternative approach to the treatment of ..
  66. ncbi 112 expression of DNA methyltransferases (dnmt) in placental tissues during early pregnancy in sheep
    A T Grazul-Bilska
    Center for Nutrition and Pregnancy, and Department of Animal Sciences, North Dakota State University, Fargo, ND 58108, USA
    Reprod Fertil Dev 23:161. 2011
    Normal placental development is critical for placental function and thus for normal embryonic and fetal growth and development. Many factors, including those from the environment or from the application of assisted reproductive techniques,..
  67. ncbi Pediatric stress: hormonal mediators and human development
    Evangelia Charmandari
    Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Horm Res 59:161-79. 2003
    ..By contrast, inappropriate responsiveness of the stress system may impair growth and development, and may account for a number of endocrine, metabolic, autoimmune and psychiatric disorders...
  68. ncbi Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders
    Katalin Sas
    Department of Neurology, University of Szeged, POB 427, H 6701 Szeged, Hungary
    J Neurol Sci 257:221-39. 2007
    ..This program plays an essential role in regulating growth and development, in the differentiation of immune cells, and in the elimination of abnormal cells from the organism...
  69. ncbi Pinniped diving response mechanism and evolution: a window on the paradigm of comparative biochemistry and physiology
    P W Hochachka
    Department of Zoology, University of British Columbia, BC, V6T 1Z4, Vancouver, Canada
    Comp Biochem Physiol A Mol Integr Physiol 126:435-58. 2000
    ..War II, the discipline of comparative physiology and biochemistry experienced a period of unprecedented growth and development that pioneers in this field thought would never end...
  70. ncbi Effects of selected plant essential oils on the growth and development of mouse preimplantation embryos in vivo
    M Domaracký
    Institute of Animal Physiology, Slovak Academy of Sciences, Kosice, Slovak Republic
    Physiol Res 56:97-104. 2007
    ..Myrtaceae) and cinnamon EO from Cinnamomum zeylanicum Blume (Lauraceae) on the growth and development of mouse preimplantation embryos in vivo...
  71. ncbi The effect of age on the change in deformity after anterior débridement surgery for tuberculosis of the spine
    S S Upadhyay
    Department of Orthopaedic Surgery, Duchess of Kent Children s Hospital at Sandy Bay, Hong Kong
    Spine (Phila Pa 1976) 21:2356-62. 1996
    ..spine responds to anterior débridement surgery (without bone grafting) for spinal tuberculosis during growth and development. Sixty-three patients were studied, 29 of whom were children aged 10 years or less at the time of surgery, ..
  72. ncbi Growth and development of premature infants fed predominantly human milk, predominantly premature infant formula, or a combination of human milk and premature formula
    Deborah L O'Connor
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    J Pediatr Gastroenterol Nutr 37:437-46. 2003
    ..2 point improvement in IQ tests. However, in the studies in this meta-analysis, feeding regimens were used (unfortified human milk, term formula) that no longer represent recommended practice...
  73. ncbi Mechanisms of inhibin signal transduction
    D J Bernard
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Recent Prog Horm Res 56:417-50. 2001
    ..stimulate FSH secretion from primary pituitary cultures and are now known to play important roles in growth and development (Woodruff, 1998; Pangas and Woodruff, 2000)...
  74. ncbi Muscle growth and development in normal-sex-ratio and all-female diploid and triploid Atlantic salmon
    I A Johnston
    Gatty Marine Laboratory, School of Environmental and Evolutionary Biology, University of St Andrews, St Andrews, Fife KY16 8LB, Scotland
    J Exp Biol 202:1991-2016. 1999
    ..Thus, a lower density of satellite cells was associated with reduced rates of fibre recruitment but a compensatory increase in muscle fibre hypertrophy in triploid compared with diploid fish...
  75. pmc A rich TILLING resource for studying gene function in Brassica rapa
    Pauline Stephenson
    Department of Crop Genetics, John Innes Centre, Norwich, NR4 7UH, UK
    BMC Plant Biol 10:62. 2010
    ..thaliana are closely related, and it is expected that knowledge obtained relating to Arabidopsis growth and development can be translated into Brassicas for crop improvement...
  76. ncbi 217 effects of porcine granulocyte-macrophage colony-stimulating factor on porcine in vitro-fertilized embryos
    S S Kwak
    Laboratory of Veterinary Embryology and Biotechnology VETEMBIO, College of Veterinary Medicine, Chungbuk National University, Cheongju 361 763, Republic of Korea
    Reprod Fertil Dev 23:207-8. 2011
    ..the female reproductive tract and is one of the regulatory molecules that mediate maternal effects on the growth and development of pre-implantation embryos in several species...
  77. ncbi Development and regenerative ability of bladder in the transgenic epidermal growth factor receptor gene knockout mouse
    M J DiSandro
    Department of Urology, University of California San Francisco, USA
    J Urol 158:1058-65. 1997
    During embryogenesis we have previously shown that urothelium is essential for normal bladder growth and development. Urothelial growth may be mediated by peptides of the epidermal growth factor family, since the epidermal growth factor ..
  78. ncbi The optimal duration of exclusive breastfeeding: a systematic review
    Michael S Kramer
    Departments of Pediatrics and of Epidemiology and Biostatistics, McGill University Faculty of Medicine, Montreal, Quebec, Canada H3A 1A2
    Adv Exp Med Biol 554:63-77. 2004
    ....
  79. ncbi [Relationship of fetal total bile acid and the change of fetal pancreas endocrine secretion and its impact on fetal growth and development in intrahepatic cholestasis of pregnancy]
    Xian ying Cheng
    Department of Obstetrics and Gynecology, Xiangya Second Hospital, Central South University, Changsha 410011, China
    Zhonghua Fu Chan Ke Za Zhi 44:23-6. 2009
    To investigate the relationship of fetal total bile acid (TBA) concentration with the change of fetal pancreas endocrine secretion and its impact on fetal growth and development in intrahepatic cholestasis of pregnancy (ICP).
  80. ncbi Imprinting of the mouse Igf2r gene depends on an intronic CpG island
    A Wutz
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Mol Cell Endocrinol 140:9-14. 1998
    ..the limited knowledge we have of imprinted genes it seems clear that they play a role in regulating the growth and development of the placenta and embryo in utero, and also in the early post-natal phase...
  81. ncbi Changes in levels of juvenile hormone and molting hormone in larvae and adult females of Chilo suppressalis (Lepidoptera: Pyralidae) after imidacloprid applications to rice
    Yue Shu Yu
    Plant Protection College, Yangzhou University, Yangzhou 225009, People s Republic of China
    J Econ Entomol 100:1188-93. 2007
    Insect hormones regulate growth and development and fecundity of insects...
  82. pmc Microarray analysis of iron deficiency chlorosis in near-isogenic soybean lines
    Jamie A O'Rourke
    1Department of Genetics, Developmental and Cellular Biology, Iowa State University, Ames, Iowa 50011, USA
    BMC Genomics 8:476. 2007
    Iron is one of fourteen mineral elements required for proper plant growth and development of soybean (Glycine max L. Merr.)...
  83. ncbi Maternal smoking and infantile gastrointestinal dysregulation: the case of colic
    Edmond D Shenassa
    Department of Community Health and Centers for Behavioral and Preventive Medicine, Brown Medical School, One Hoppin St, Suite 500, Providence, RI 02903, USA
    Pediatrics 114:e497-505. 2004
    Infants' healthy growth and development are predicated, in part, on regular functioning of the gastrointestinal (GI) tract. In the first 6 months of life, infants typically double their birth weights...
  84. ncbi Growth and development in preterm infants fed long-chain polyunsaturated fatty acids: a prospective, randomized controlled trial
    D L O'Connor
    Ross Products Division, Abbott Labs, Columbus, Ohio, USA
    Pediatrics 108:359-71. 2001
    ....
  85. ncbi Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice
    C Bole-Feysot
    INSERM Unité 344 Endocrinologie Moléculaire, Faculte de Medecine Necker, Paris, France
    Endocr Rev 19:225-68. 1998
    ..actions of PRL have been reported in various vertebrates, including effects on water and salt balance, growth and development, endocrinology and metabolism, brain and behavior, reproduction, and immune regulation and protection...
  86. pmc Connexin43 gap junctions in normal, regenerating, and cultured mouse bone marrow and in human leukemias: their possible involvement in blood formation
    T Krenacs
    Department of Anatomy and Developmental Biology, University College London, United Kingdom
    Am J Pathol 152:993-1004. 1998
    Communicating channels called gap junctions are thought to play a ubiquitous part in cell growth and development. Based on earlier work, we have recently found functional evidence of their presence in human and mouse bone marrow...
  87. ncbi Redox signaling in the growth and development of colonial hydroids
    Neil W Blackstone
    Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA
    J Exp Biol 206:651-8. 2003
    Redox signaling provides a quick and efficient mechanism for clonal or colonial organisms to adapt their growth and development to aspects of the environment, e.g. the food supply...
  88. pmc CHARGE (coloboma, heart defect, atresia choanae, retarded growth and development, genital hypoplasia, ear anomalies/deafness) syndrome and chromosome 22q11.2 deletion syndrome: a comparison of immunologic and nonimmunologic phenotypic features
    Soma Jyonouchi
    Children s Hospital of Philadelphia, Division of Allergy and Immunology, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA
    Pediatrics 123:e871-7. 2009
    CHARGE (coloboma, heart defect, atresia choanae, retarded growth and development, genital hypoplasia, ear anomalies/deafness) syndrome and chromosome 22q11...
  89. pmc Association of traffic-related air pollution with children's neurobehavioral functions in Quanzhou, China
    Shunqin Wang
    Department of Occupational and Environmental Health Science, School of Public Health, Peking University, Beijing, People s Republic of China
    Environ Health Perspect 117:1612-8. 2009
    ..Because of their fast growth and development, children are more susceptible to ambient air pollution exposure...
  90. pmc Growth and development of the placenta in the capybara (Hydrochaeris hydrochaeris)
    Claudia Kanashiro
    Department of Physiology and Pharmacology, University of Southern Denmark, Odense, Denmark
    Reprod Biol Endocrinol 7:57. 2009
    ..We paid attention to the development of the lobulated arrangement of the placenta, the growth of the labyrinth in the course of gestation, the differentiation of the subplacenta, and the pattern of invasion by extraplacental trophoblast...
  91. ncbi Effect of transforming growth factor-beta1 on embryonic and posthatch muscle growth and development in normal and low score normal chicken
    X Li
    Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster 44691, USA
    Poult Sci 88:265-75. 2009
    ..The present study investigated the effect of TGF-beta1 on in vivo skeletal muscle growth and development. A chicken line, Low Score Normal (LSN) with reduced muscling and upregulated TGF-beta1 expression, was ..
  92. ncbi Developmental expression of cell cycle regulators in the baboon fetal adrenal gland
    Adina Dumitrescu
    Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Endocrinol 192:237-47. 2007
    ..primate fetal adrenal glands undergo a highly unique pattern of cortical zone-specific intrauterine growth and development, studies of the regulatory components of the cell cycle responsible for this growth have not been ..
  93. ncbi Expression of cinnamyl alcohol dehydrogenases and their putative homologues during Arabidopsis thaliana growth and development: lessons for database annotations?
    Sung Jin Kim
    Institute of Biological Chemistry, Washington State University, Pullman, WA 99164 6340, USA
    Phytochemistry 68:1957-74. 2007
    ..Just as importantly, the different patterns of gene expression noted during distinct phases of growth and development in specific cells/tissues gives insight into the study of the roles that these promoters have.
  94. ncbi Two generation reproduction study of styrene by inhalation in Crl-CD rats
    George Cruzan
    ToxWorks, Bridgeton, New Jersey 08302, USA
    Birth Defects Res B Dev Reprod Toxicol 74:211-20. 2005
    ..gestation, parturition, lactation, and weaning in the F0 and F1 generations, and F1 generation offspring growth and development. Four groups of male and female Crl:CD(SD)IGS BR rats (25/sex/group) were exposed to 0, 50, 150, and 500 ..
  95. ncbi The effect of intermittent umbilical cord occlusion on insulin-like growth factors and their binding proteins in preterm and near-term ovine fetuses
    L R Green
    MRC Group in Fetal and Neonatal Health and Development, Department of Physiology, The Lawson Research Institute, and The Child Health Research Institute, The University of Western Ontario, London, Ontario N6A 4V2, Canada
    J Endocrinol 166:565-77. 2000
    Intermittent umbilical cord compression with resultant fetal hypoxia can have a negative impact on fetal growth and development. Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are the most important regulators of ..
  96. pmc Long-term results of pediatric liver transplantation in a combined pediatric and adult transplant program
    Paul R Atkison
    London Health Sciences Centre, Ont
    CMAJ 166:1663-71. 2002
    ..We reviewed data from the first 16 years of a pediatric liver transplantation program to determine survival, complications and long-term outcomes...
  97. ncbi Practical management of type 1 diabetes mellitus in adolescent patients: challenges and goals
    Robert P Hoffman
    Department of Pediatrics, The Ohio State University College of Medicine and Public Health, Columbus, Ohio, USA
    Treat Endocrinol 3:27-39. 2004
    ..are to (i) prevent diabetic ketoacidosis; (ii) prevent severe hypoglycemia; (iii) maintain normal growth and development; and (iv) prevent long-term diabetic complications...
  98. ncbi Xyloglucan sidechains modulate binding to cellulose during in vitro binding assays as predicted by conformational dynamics simulations
    S Levy
    University of Colorado, Boulder 80309 0347, USA
    Plant J 11:373-86. 1997
    ..play a major role in defining the structural properties of plant cell walls and the regulation of growth and development of dicotyledonous plants...
  99. ncbi Recovery of maize seedling growth, development and photosynthetic efficiency after initial growth at low temperature
    Paweł Sowiński
    Department of Plant Biochemistry and Physiology, Plant Breeding and Acclimatization Institute, Miecznikowa 1, Warszawa 02 096, Błonie, Poland
    J Plant Physiol 162:67-80. 2005
    ..photosynthetic efficiency, as evaluated by means of phiPSII and chloroplast ultrastructure, as well as growth and development of two inbred lines (the chilling-tolerant KW 1074 and the chilling-sensitive CM 109) under laboratory ..
  100. pmc Cloning and characterisation of Schistosoma japonicum insulin receptors
    Hong You
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    PLoS ONE 5:e9868. 2010
    Schistosomes depend for growth and development on host hormonal signals, which may include the insulin signalling pathway...

Research Grants74

  1. REGULATION AND FUNCTION OF STE20-RELATED PROTEIN KINASES
    Melanie H Cobb; Fiscal Year: 2012
    ..exocytosis and vesicular trafficking;and are components of signal transduction pathways essential for growth and development. In this application, we propose experiments to elucidate mechanisms of WNK action and the functions of ..
  2. Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCT
    Brian Wong; Fiscal Year: 2013
    ..extubation, monitor progression of pathophysiologic changes during intubation, and understand the in vivo growth and development of the neonatal airway...
  3. Diverse Roles for RIC8 During G Protein Signaling in Fungi
    Katherine A Borkovich; Fiscal Year: 2012
    ..G proteins are essential components of signal transduction pathways that regulate environmental sensing, growth and development in eukaryotes...
  4. Histone Chaperones in Angiogenesis
    Soumen Paul; Fiscal Year: 2012
    ..of new blood vessels from existing vasculature, is a key event in many physiological processes, like organ growth and development, wound healing, and reproduction...
  5. Maternal Obesity and Gestational Diabetes: Impact on Metabolome
    William L Lowe; Fiscal Year: 2013
    ..milieu of the developing fetus as glucose and other molecules cross the placenta and impact fetal growth and development. We are hypothesizing that analytes comprising distinct metabolic signatures will demonstrate association ..
  6. Right Heart-Pulmonary Vascular Interactions in Bronchopulmonary Dysplasia
    Marlowe Eldridge; Fiscal Year: 2013
    ..The subsequent lung injuries impair the growth and development of the airways and pulmonary vasculature, leading to a decrease in the air exchanging units of the lung ..
  7. NEWBORN IRON DEFICIENCY
    Michael K Georgieff; Fiscal Year: 2013
    ..The fundamental mechanisms by which neurons are dependent on iron for growth and development is not understood...
  8. Genetic Control of Axial Patterning in Drosophila Eye
    Amit Singh; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): During organogenesis axial patterning is essential for growth and development. The fruit fly, Drosophila, provides an ideal model for genetic analysis of dorsoventral (DV) patterning and growth of the ..
  9. Role of Coxiella burnetii group I introns in growth modulation
    Michael F Minnick; Fiscal Year: 2010
    ..phase (LCV) to a persistent, dormant-cell (SCV) during stationary phase, and 3) being involved in growth and development, since intron RNA (ribozyme) splicing is required to form mature 23S rRNA...
  10. Primate Fetal Adrenal Development: Impact on Physiological Processes After Birth
    Eugene D Albrecht; Fiscal Year: 2013
    ..provided by applicant): The human fetal adrenal undergoes a unique pattern of cortical zone-specific growth and development which is essential for normal postnatal maturation and homeostasis, but the regulation of this process is ..
  11. Developmental Origins of Phenotypic Characteristics that Predict Longevity
    Andrzej Bartke; Fiscal Year: 2012
    ..Yet it is unknown whether (or to what extent) early growth and development influence mammalian aging...
  12. Dioxins and Male Pubertal Growth and Development
    Russ B Hauser; Fiscal Year: 2013
    ..In addition, when the boys reach adulthood, environmental risk factors for altered semen quality will also be explored. ..
  13. ANALYSIS OF CHROMATIN REMODELING IN MAMMARY GLAND DEVELOPMENT USING TILING ARRAYS
    Monique Rijnkels; Fiscal Year: 2009
    ..Milk is the primary source of nutrition for neonates it provides all the essential components for healthy growth and development of newborns of all mammalian species...
  14. Biopsychosocial Determinants of Adolescent Obesity/Cardiovascular Risk
    Sheila Gahagan; Fiscal Year: 2012
    ..between the Institute for Nutrition and Technology at the University of Chile and the Center for Human Growth and Development at the University of Michigan provides an outstanding environment to study biological and psychosocial ..
  15. Laser Spinning Disc Confocal System for live-cell and live-organism microscopy
    Martha C Soto; Fiscal Year: 2012
    ..taking advantage of model organisms to study conserved biological processes that are essential for healthy growth and development and that are compromised in disease conditions. C...
  16. Delayed pubertal development on the mechanism of bone loss at maturity
    Vanessa R Yingling; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Fracture risk in the elderly has its origins during growth and development. A delay in the onset of puberty results in both low bone mass and an increased incidence of stress ..
  17. Routine Aspiration of Residual Gastric Contents in Very Low Birth Weight Infants
    Leslie A Parker; Fiscal Year: 2013
    ..birth in premature very low birth weight (VLBW) infants is well known and necessary to facilitate optimal growth and development and reduce both premature birth-related and iatrogenic complications...
  18. Glucose energy metabolism in the growth and survival of B lymphocytes
    THOMAS CRANE CHILES; Fiscal Year: 2010
    ..During the past three decades the role of the B-cell antigen receptor (BCR) in promoting B-cell growth and development has been established. It is also clear that co-receptors (e.g...
  19. USC Research Center for Liver Disease
    Neil Kaplowitz; Fiscal Year: 2013
    ..transduction and transport: d) regulatory biology: liver metabolism, gene expression, and liver/intestinal growth and development. Four core facilities support this Research Base: 1) Administrative Core which oversees the operations and ..
  20. Striated Muscle Gene Transcription and Regulatory Gene Cassettes for Gene Therapy
    STEPHEN DENISON HAUSCHKA; Fiscal Year: 2012
    ..factors is critical for obtaining a full understanding of how muscle genes are regulated during human growth and development and in both healthy and diseased adult muscle...
  21. The role of polyphosphate and acidocalcisomes in Trypanosoma brucei
    Roberto Docampo; Fiscal Year: 2013
    ..brucei, the targeting mechanism of transmembrane proteins to this organelle, and the roles of pyrophosphate and polyphosphate metabolism in T. brucei growth and development.
  22. Bisphenol A and Children's Growth & Development
    KIM G contact HARLEY; Fiscal Year: 2010
    ..dataset, the intent is to examine the association of BPA exposure in utero and in childhood with child growth and development. The specific aims are: 1) to measure BPA concentrations in urine collected from ~400 mothers during ..
  23. Role of SATB in placental development
    Mohammad A K Rumi; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The growth and development of the placenta is dependent upon expansion and lineage specific differentiation of a population of stem cells referred to as trophoblast stem (TS) cells...
  24. Effects of Maternal Influenza Immunization: A Field Trial in Guatemala'
    Saad B Omer; Fiscal Year: 2010
    ..can cause serious illness in pregnant women and their infants and can have an adverse impact on fetal growth and development. Influenza virus is an important respiratory pathogen that causes substantial burden of disease - ..
  25. Small Oligonucleotides As Therapeutic Agents Of Spinal Muscular Atrophy
    Ravindra N Singh; Fiscal Year: 2012
    ..We will determine the effect of different doses of our optimized lead ASO on the phenotype, growth and development of SMA mice. In particular, we seek to improve the longevity of SMA mice...
  26. Growth and Cardiometabolic Risk Among In Utero Drug Exposed Children
    SARAH ELIZABETH MESSIAH; Fiscal Year: 2013
    ..Messiah will examine the relationship between in utero cocaine exposure, anthropometric growth and development of cardiometabolic disease risk factors in African American children at ages 16-18...
  27. Function of the Zinc Finger Protein ZPR1 in neurodegeneration
    LAXMAN DASS GANGWANI; Fiscal Year: 2013
    ..We will examine the effect of ZPR1 overexpression on the growth and differentiation of neurons and growth and development of mice...
  28. VCU Building Interdisciplinary Research Careers in Women's Health
    Jerome F Strauss; Fiscal Year: 2011
    ..at VCD is to provide the structured learning environment envisioned by the NIH Roadmap that will encourage growth and development of junior faculty into independent researchers with the investigative, networking, management, publication,..
  29. Perinatal Stress and programming of childhood wheeze and lung function
    Rosalind J Wright; Fiscal Year: 2013
    ..influence neuroendocrine and immune processes suggest their possible role in wheeze expression and lung growth and development. We propose that stress-elicited disruption of interrelated systems - neuroendocrine, autonomic, and ..
  30. c-Myc transcription in intestinal growth, differentiation, and carcinogenesis
    Gregory S Yochum; Fiscal Year: 2012
    DESCRIPTION (PROVIDED BY APPLICANT): The Wnt signaling pathway is essential for normal intestinal growth and development, and inappropriate activation of this pathway is associated with colorectal cancer...
  31. QTL and QTL Genes Underlying Lactation Performance
    Darryl L Hadsell; Fiscal Year: 2010
    Breastfeeding is now widely accepted as important to optimizing health, growth and development of humans and reducing the financial burden for health care in the United States...
  32. Nonsense Mediated RNA Decay Regulation in Erythropoiesis &Thalassemia
    LAWRENCE BENJAMIN GARDNER; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The normal growth and development of red blood cells is vital to sustain health...
  33. RNA Polymerase Transcription Past DNA Adducts
    David A Scicchitano; Fiscal Year: 2013
    ..mutations and cancer, they may well pose threats to non-dividing cells and disturb RNA synthesis during growth and development, adding to their impact on human health...
  34. Mechanisms of Race-Based Differences in Factor VIII Immunogenicity in Hemophilia
    KATHLEEN PALMER PRATT; Fiscal Year: 2010
    ..DNA and plasma collected as part of the Hemophilia Growth and Development Study (HGDS) funded by the NIH/NICHD, and also from a Canadian Repository, will also be studied...
  35. Alternative Splicing of the Insulin Receptor Gene
    NICHOLAS J WEBSTER; Fiscal Year: 2013
    ..Insulin is essential for growth and development in addition to fuel metabolism...
  36. Mitochondrial Gene Therapy
    Shoukhrat M Mitalipov; Fiscal Year: 2013
    ..3. Study growth and development of monkeys produced by ST and examine mtDNA transmission in the ST female germline...
  37. Small Regulatory RNAs of Coxiella burnetii - The Agent of Q Fever
    JAMES MICHAEL BATTISTI; Fiscal Year: 2013
    ..In aim 1, we will identify sRNAs involved in regulating Coxiella's growth and development by characterizing sRNA profiles of SCVs and LCVs using high-throughput (deep) sequencing technology...
  38. Effects of Bisphenol A Exposure on Genomic Imprinting in the Mouse
    Martha Susiarjo; Fiscal Year: 2012
    ..Imprinted genes, as well as appropriate imprinted gene expression patterns, are essential for normal growth and development in mammals...
  39. Mechanisms of Action and Signaling by Steroid Hormone Antagonists
    Douglas V Faller; Fiscal Year: 2013
    ..Prostate tumors and most breast tumors depend, at least initially, upon circulating hormones for their growth and development. Estrogen antagonists and androgen antagonists comprise the most widely-used endocrine therapies for ..
  40. The Insulin/IGF-I Axis in Diabetic Osteopathy
    John L Fowlkes; Fiscal Year: 2013
    ..in osteoblasts (OIRKO mice) in regards to in utero skeletal development, postnatal affects on skeletal growth and development, and de novo bone formation...
  41. A phase Ib/II study of AZD2171 and radiation for new brain metastases from NSCLC
    APRIL FITZSIMMONS EICHLER; Fiscal Year: 2010
    ..The growth and development of brain metastases is critically dependent on a functional blood supply...
  42. Mechanotransduction in the Ciliary Muscle
    Andrew D Pucker; Fiscal Year: 2013
    ..will receive advanced training in microscopy and genetic analysis in order to characterize smooth muscle growth and development. The applicant will also learn tissue culture immortalization and cell stretching techniques...
  43. Role of chromatin structure in regulating gene silencing
    Mary Bryk; Fiscal Year: 2009
    ..Furthermore, gene silencing is critical for normal growth and development. When the processes that regulate gene silencing are disrupted in mammalian cells, inappropriate gene ..
  44. Neuroimmunology and Behavior: Natural Antagonism of Sickness and Depression
    Robert H McCusker; Fiscal Year: 2013
    ..We recently discovered that insulin-like growth factor-I (IGF-I), a hormone that is critical for growth and development and whose endogenous-tonic presence is neuroprotective, inhibits sickness behavior when given either ..
  45. Genetic analysis of DNA methylation in Neurospora crassa
    ANDREW DAVID KLOCKO; Fiscal Year: 2013
    ..The establishment and maintenance of heterochromatin and DNA methylation is essential for the proper growth and development of all organisms...
  46. The Common Marmoset as a Primate Model of Maternal Obesity
    SUZETTE D contact TARDIF; Fiscal Year: 2010
    ..body composition and circulating concentrations of CRH, leptin and estradiol;placental and fetal growth and development, including placental function assessed through stereology and estimates of placental CRH, leptin and IGF ..
  47. Analyses of two RNA helicases that affect intercellular transport via plasmodesma
    Patricia C Zambryski; Fiscal Year: 2012
    ..and intercellular signaling pathways are critical for the coordination of gene expression during growth and development in multicellular organisms...
  48. GLYCOSPHINGOLIPID METABOLISM AND MENTAL RETARDATION
    Glyn Dawson; Fiscal Year: 2013
    ..The broad, long-term objective of this proposal is to study several mouse models of human disease, growth and development with innovative technology to better understand the role of glycolipids and sphingolipids in mental ..
  49. Omega-3 Fatty Acid Administration In Dialysis Patients
    Talat Alp Ikizler; Fiscal Year: 2010
    ..Omega-3 fatty acids are essential for normal growth and development and have been shown to influence coronary artery disease, hypertension, arthritis, inflammatory disorders, ..
  50. Nutrient Restriction: Placental and Fetal Brain and Renal Outcomes and Mechanism
    Peter W Nathanielsz; Fiscal Year: 2012
    ..Sub-optimal fetal (F) organ growth and development are major problems associated with increased neonatal death and long term morbidity...
  51. Stat5b in Lymphomagenesis: Mechanistic and Therapeutic Implications
    John A Kelly; Fiscal Year: 2012
    ..q.) injected cells will define the malignant subpopulations. Subaim 2: Define requirements for growth and development of immature thymic precursors in Stat5b TG mice...
  52. Role of Fgfr2IIIb in epithelial mesenchymal signaling in intestinal development
    Peter F Nichol; Fiscal Year: 2013
    ..FGF signaling is a critical regulator of intestinal growth and development. Our preliminary studies indicate that conditional mutation of Fgfr2IIIb in the colonic epithelium ..
  53. Mechanisms of Metal Ion Regulation in Human Cells
    Svetlana Lutsenko; Fiscal Year: 2013
    ..Copper deficiency is deleterious to human growth and development, yet excess copper is toxic...
  54. Regulation of Forebrain Neurogenesis by the Energy Sensor AMP Kinase
    Biplab Dasgupta; Fiscal Year: 2013
    ..processes including regulation of cell structures, polarity, cell division, migration and normal growth and development of organisms...
  55. Regulation of Eye Growth and Development by the Lens
    William R Jeffery; Fiscal Year: 2012
    ..how a lens becomes dysfunctional through apoptosis and how an abnormal lens in turn affects overall growth and development of the eye. The first two aims focus on events leading to apoptosis within the lens...
  56. Rare Liver Disease Network
    Ronald J Sokol; Fiscal Year: 2010
    ..if not fatal consequences (without liver transplantation) and severely affect the child's normal growth and development. The five related disorders are alpha-1-antitrypsin deficiency, Alagille syndrome, progressive familial ..
  57. The Molecular Genetics of High Myopia
    Terri Lois Young; Fiscal Year: 2013
    ..into the molecular basis of this significant eye disorder, but will also identify pathways involved in eye growth and development. This effort may lead to effective therapies to treat or potentially prevent this common eye condition.
  58. Large Animal Model for Novel Autologous Treatments of Alveolar Clefts
    JOHN ANANDA VAN AALST; Fiscal Year: 2013
    ..Dr. Allbritton is a physician scientist who provides an example for the candidate's future career growth and development, and has expertise in bioengineered mechanisms to control single cell function. Dr...
  59. Establishment of a phenotypical model of adverse outcomes associated with ART
    KEVIN DALE WELLS; Fiscal Year: 2011
    ..Imprinted genes are frequently found in clusters and many are involved in regulating growth and development of the fetus and placenta...
  60. Transcription Regulation in the Aging Heart
    Jeanne Y Wei; Fiscal Year: 2010
    ..dominant negative transgenic mice had dilated hearts with abnormally small cardiomyocytes, poor postnatal growth and development, and all died within 12 days after birth...
  61. Chronic Cadmium Exposure Promotes Breast Cancer Progression
    Maggie C Louie; Fiscal Year: 2012
    ..mediated by the estrogen receptor (ER) which in turn regulates the expression of genes necessary for the growth and development of the mammary gland...
  62. Nicotine, nicotinic receptors and lung cancer
    Eliot R Spindel; Fiscal Year: 2013
    ..growth;2, To determine the role of the a5D398 to a5N398 mutation (rs16969968) in mediating increased growth and development of lung cancer;and 3, To determine if there are additional common polymorphisms in the a3, a5 and [..
  63. Neuroendocrine Mechanisms of Developmental Massage Therapy in Preterm Infants
    Laurie Moyer Mileur; Fiscal Year: 2009
    ..of massage therapy in premature infants are needed to: 1) further our understanding of postnatal growth and development and 2) ultimately promote the integration of a massage therapy with conventional medical care...
  64. MATERNAL DEHYDRATION--FETAL/AMNIOTIC FLUID HOMEOSTASIS
    Michael Ross; Fiscal Year: 2002
    Amniotic fluid (AF) is an essential accompaniment of normal pregnancy, necessary for fetal movement, growth and development. Oligohydramnios, or reduced AF volume, occurs in 8 to 38 percent of all pregnancies...
  65. Investigating the role of leptin in larval growth and limb development in Xenopus
    ERICA CRESPI; Fiscal Year: 2009
    ..will conduct a combination of morpholino knockdown and leptin overexpression experiments and monitor both growth and development of specific tissues...
  66. ETHANOL PLACENTO TOXICITY--INSULIN AND IGF-1 SIGNALLING
    Stanley Fisher; Fiscal Year: 1999
    The human placenta, a tissue primarily of fetal origin, is the critical maternal/fetal interface. Fetal growth and development depend upon normal placental function...
  67. VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.
    Frederica Perera; Fiscal Year: 2004
    ..a strong theoretical framework to guide assessment of the impacts of these pollutants on fetal and child growth and development The specific aims are: 1...
  68. DEVELOPMENT OF NEW SCID MOUSE MODELS FOR AIDS RESEARCH
    Leonard Shultz; Fiscal Year: 1999
    ..Despite such improved engraftment, the function of transplanted human lymphoid cells as well as the growth and development of human hematopoietic stem cells has been limited by the expression of murine major histocompatibility ..
  69. Animal models to examine role of ZPR1 protein complexes
    LAXMAN DASS GANGWANI; Fiscal Year: 2010
    ..of proposed research is to understand the physiological role of zinc finger protein ZPR1 complexes in cell growth and development. ZPR1 interacts with survival motor neuron (SMN) and eukaryotic translation elongation factor 1A (eEF1A) ..
  70. MECHANISMS OF BONE GROWTH IN FISH HYPEROSTOSIS
    Leslie Kaufman; Fiscal Year: 1992
    Alterations in the regulation of skeletal and mineral metabolism are involved in many abnormalities of growth and development, in osteopetrosis, rickets, osteoporosis, and inflammatory disorders such as arthritis and periodontal disease...
  71. Rapid Field Test for Iodine Levels in Salt
    Bikas Vaidya; Fiscal Year: 2012
    ..It also decreases child survival, causes goiters, and impairs growth and development. Iodine deficiency in pregnant women causes miscarriages, stillbirths, and other complications...
  72. REGULATION OF HUMAN PLACENTAL GROWTH BY IGFS
    Michael Fant; Fiscal Year: 1993
    The primary function of the human placenta is to ensure an optimal environment for fetal growth and development. Essential to this role is the programmed growth and development of the placenta...
  73. Nonhematopoietic Developmental Functions of EPO
    Sandra Juul; Fiscal Year: 2004
    ..Pilot studies suggest that Epo may enhance the growth and development of neonatal intestine, and may also protect the neonatal intestine from injury...
  74. Genetic and Environmental Influences on Childhood Growth
    Bradford Towne; Fiscal Year: 2006
    ..of the proposed study is to elucidate the roles of genetic and environmental factors influencing childhood growth and development, with particular focus on gene-environment interactions...