biological clocks

Summary

Summary: The physiological mechanisms that govern the rhythmic occurrence of certain biochemical, physiological, and behavioral phenomena in plants and animals.

Top Publications

  1. ncbi Coordinated transcription of key pathways in the mouse by the circadian clock
    Satchidananda Panda
    The Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Cell 109:307-20. 2002
  2. ncbi The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator
    Nicolas Preitner
    Department of Molecular Biology, Sciences II, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 4, Geneva, Switzerland
    Cell 110:251-60. 2002
  3. ncbi Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells
    Emi Nagoshi
    Department of Molecular Biology and NCCR Frontiers in Genetics, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    Cell 119:693-705. 2004
  4. pmc Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
    F Damiola
    , Sciences II, , CH-1211 Geneva, Switzerland
    Genes Dev 14:2950-61. 2000
  5. ncbi Phototransduction by retinal ganglion cells that set the circadian clock
    David M Berson
    Department of Neuroscience, Brown University, Providence, RI, 02912 USA
    Science 295:1070-3. 2002
  6. ncbi Resetting of circadian time in peripheral tissues by glucocorticoid signaling
    A Balsalobre
    , Sciences II, , 30 Quai Ernest Ansermet, , Switzerland
    Science 289:2344-7. 2000
  7. ncbi A mechanism for cognitive dynamics: neuronal communication through neuronal coherence
    Pascal Fries
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
    Trends Cogn Sci 9:474-80. 2005
  8. ncbi Cross-frequency coupling between neuronal oscillations
    Ole Jensen
    F C Donders Centre for Cognitive Neuroimaging, Kapittelweg 29, NL 6525 EN Nijmegen, The Netherlands
    Trends Cogn Sci 11:267-9. 2007
  9. ncbi Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
    G T van der Horst
    MGC, Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Nature 398:627-30. 1999
  10. pmc Intercellular coupling confers robustness against mutations in the SCN circadian clock network
    Andrew C Liu
    Department of Biochemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 129:605-16. 2007

Research Grants

  1. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
  2. Circadian Expression of Procolipase in the Liver: A Metabolic Signal
    Mark E Lowe; Fiscal Year: 2010
  3. Circadian Programs in Bacteria
    Carl Hirschie Johnson; Fiscal Year: 2013
  4. Circadian Regulation of Gonadotropin-Releasing Hormone
    Patrick E Chappell; Fiscal Year: 2010
  5. Biological Rhythms and Immune Function
    Brian J Prendergast; Fiscal Year: 2013
  6. Structure and Function of Circadian Clock Light Sensors
    Brian R Crane; Fiscal Year: 2013
  7. COORDINATION OF CIRCADIAN PHYSIOLOGY OF DIVERSE SPECIES
    Deborah Bell Pedersen; Fiscal Year: 2010
  8. Structural Biology of the S. elongatus Circadian Clock
    Martin Egli; Fiscal Year: 2013
  9. Circadian Clock Gene Polymorphisms Associated with Depression
    Carl Hirschie Johnson; Fiscal Year: 2010
  10. Analysis of EGFR-dependent sleep in C. elegans
    CHERYL LYNN VAN BUSKIRK; Fiscal Year: 2013

Detail Information

Publications348 found, 100 shown here

  1. ncbi Coordinated transcription of key pathways in the mouse by the circadian clock
    Satchidananda Panda
    The Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
    Cell 109:307-20. 2002
    ..Importantly, rate-limiting steps in these various pathways were key sites of circadian control, highlighting the fundamental role that circadian clocks play in cellular and organismal physiology...
  2. ncbi The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator
    Nicolas Preitner
    Department of Molecular Biology, Sciences II, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 4, Geneva, Switzerland
    Cell 110:251-60. 2002
    ..While REV-ERBalpha influences the period length and affects the phase-shifting properties of the clock, it is not required for circadian rhythm generation...
  3. ncbi Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells
    Emi Nagoshi
    Department of Molecular Biology and NCCR Frontiers in Genetics, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    Cell 119:693-705. 2004
    ..Specifically, the circadian oscillator gates cytokinesis to defined time windows, and mitosis elicits phase shifts in circadian cycles...
  4. pmc Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
    F Damiola
    , Sciences II, , CH-1211 Geneva, Switzerland
    Genes Dev 14:2950-61. 2000
    ..Food-induced phase resetting proceeds faster in liver than in kidney, heart, or pancreas, but after 1 wk of daytime feeding, the phases of circadian gene expression are similar in all examined peripheral tissues...
  5. ncbi Phototransduction by retinal ganglion cells that set the circadian clock
    David M Berson
    Department of Neuroscience, Brown University, Providence, RI, 02912 USA
    Science 295:1070-3. 2002
    ..The sensitivity, spectral tuning, and slow kinetics of this light response matched those of the photic entrainment mechanism, suggesting that these ganglion cells may be the primary photoreceptors for this system...
  6. ncbi Resetting of circadian time in peripheral tissues by glucocorticoid signaling
    A Balsalobre
    , Sciences II, , 30 Quai Ernest Ansermet, , Switzerland
    Science 289:2344-7. 2000
    ..In contrast to the central clock, circadian oscillators in peripheral tissues appear to remain responsive to phase resetting throughout the day...
  7. ncbi A mechanism for cognitive dynamics: neuronal communication through neuronal coherence
    Pascal Fries
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
    Trends Cogn Sci 9:474-80. 2005
    ..Thus, a flexible pattern of coherence defines a flexible communication structure, which subserves our cognitive flexibility...
  8. ncbi Cross-frequency coupling between neuronal oscillations
    Ole Jensen
    F C Donders Centre for Cognitive Neuroimaging, Kapittelweg 29, NL 6525 EN Nijmegen, The Netherlands
    Trends Cogn Sci 11:267-9. 2007
    ..Given that this coupling reflects a specific interplay between large ensembles of neurons, it is likely to have profound implications for neuronal processing...
  9. ncbi Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
    G T van der Horst
    MGC, Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Nature 398:627-30. 1999
    ..This suggests that, in addition to a possible photoreceptor and antagonistic clock-adjusting function, both proteins are essential for the maintenance of circadian rhythmicity...
  10. pmc Intercellular coupling confers robustness against mutations in the SCN circadian clock network
    Andrew C Liu
    Department of Biochemistry, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 129:605-16. 2007
    ....
  11. pmc Altered circadian rhythms regulate growth vigour in hybrids and allopolyploids
    Zhongfu Ni
    Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, One University Station, A 4800, Austin, Texas 78712, USA
    Nature 457:327-31. 2009
    ..The causal effects of CCA1 on output traits suggest that hybrids and allopolyploids gain advantages from the control of circadian-mediated physiological and metabolic pathways, leading to growth vigour and increased biomass...
  12. pmc Suprachiasmatic nucleus: cell autonomy and network properties
    David K Welsh
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Annu Rev Physiol 72:551-77. 2010
    ..Thus, even though individual SCN neurons can be cell-autonomous circadian oscillators, neuronal network properties are integral to normal function of the SCN...
  13. ncbi Rhythmic growth explained by coincidence between internal and external cues
    Kazunari Nozue
    Section of Plant Biology, College of Biological Sciences, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
    Nature 448:358-61. 2007
    ..This interaction may serve as a paradigm for understanding how endogenous and environmental signals cooperate to control other processes...
  14. ncbi A synthetic oscillatory network of transcriptional regulators
    M B Elowitz
    Department of Molecular Biology and Physics, Princeton University, New Jersey 08544, USA
    Nature 403:335-8. 2000
    ..Such 'rational network design may lead both to the engineering of new cellular behaviours and to an improved understanding of naturally occurring networks...
  15. ncbi A functional genomics strategy reveals Rora as a component of the mammalian circadian clock
    Trey K Sato
    Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, California 92121, USA
    Neuron 43:527-37. 2004
    ..These results suggest that opposing activities of the orphan nuclear receptors Rora and Rev-erb alpha, which represses Bmal1 expression, are important in the maintenance of circadian clock function...
  16. ncbi A serum shock induces circadian gene expression in mammalian tissue culture cells
    A Balsalobre
    Departement de Biologie Moleculaire, Sciences II, Universite de Geneve, Switzerland
    Cell 93:929-37. 1998
    ..The serum shock of rat-1 fibroblasts also results in a transient stimulation of c-fos and rper expression and thus mimics light-induced immediate-early gene expression in the suprachiasmatic nucleus...
  17. pmc A synchronized quorum of genetic clocks
    Tal Danino
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA
    Nature 463:326-30. 2010
    ..Furthermore, it provides a specific model system for the generation of a mechanistic description of emergent coordinated behaviour at the colony level...
  18. ncbi Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock
    K Bae
    Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital, and, Harvard Medical School, 02114, Boston, MA, USA
    Neuron 30:525-36. 2001
    ..Thus, mPER1 influences rhythmicity primarily through interaction with other clock proteins, while mPER2 positively regulates rhythmic gene expression, and there is partial compensation between products of these two genes...
  19. pmc System-driven and oscillator-dependent circadian transcription in mice with a conditionally active liver clock
    Benoît Kornmann
    Department of Molecular Biology, University of Geneva, Geneva, Switzerland
    PLoS Biol 5:e34. 2007
    ..The finding that rhythmic mPer2 expression can be driven by both systemic cues and local oscillators suggests a plausible mechanism for the phase entrainment of subsidiary clocks in peripheral organs...
  20. pmc REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis
    Gwendal Le Martelot
    Department of Molecular Biology and NCCR Frontiers in Genetics, Sciences III, University of Geneva, Geneva, Switzerland
    PLoS Biol 7:e1000181. 2009
    ..In conclusion, our study suggests that rhythmic cholesterol and bile acid metabolism is not just driven by alternating feeding-fasting cycles, but also by REV-ERBalpha, a component of the circadian clockwork circuitry...
  21. ncbi Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell
    John J Tyson
    Department of Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Curr Opin Cell Biol 15:221-31. 2003
    ..These models shed light on the design principles of biological control systems and make predictions that have been verified experimentally...
  22. ncbi Theta oscillations in the hippocampus
    Gyorgy Buzsaki
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey and Neurological Institute of New Jersey, Newark, NJ 07102, USA
    Neuron 33:325-40. 2002
    ..Nevertheless, numerous critical issues regarding both the generation of theta oscillations and their functional significance remain challenges for future research...
  23. ncbi Circadian rhythms in isolated brain regions
    Michikazu Abe
    National Science Foundation Center for Biological Timing and Department of Biology, University of Virginia, Charlottesville, Virginia 22904, USA
    J Neurosci 22:350-6. 2002
    ..The phasing of these oscillators to one another may play a critical role in coordinating brain activity and its adjustment to changes in the light cycle...
  24. ncbi Nuclear receptor expression links the circadian clock to metabolism
    Xiaoyong Yang
    Gene Expression Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell 126:801-10. 2006
    ....
  25. ncbi Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain
    Brigitte Grima
    Institut de Neurobiologie Alfred Fessard NGI, CNRS UPR 2216, Centre National de la Recherche Scientifique, av de la Terrasse, 91198 Gif sur Yvette, France
    Nature 431:869-73. 2004
    ..Furthermore, we show that the LN(v)s alone can generate 24 h activity rhythms in constant darkness, indicating that the morning oscillator is sufficient to drive the circadian system...
  26. ncbi Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus
    Ruth A Akhtar
    Department of Genetics, University of Leicester, LE1 7RH, Leicester, United Kingdom
    Curr Biol 12:540-50. 2002
    ..We used a custom-made cDNA microarray to identify mouse liver transcripts that show circadian cycles of abundance under constant conditions...
  27. ncbi Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways
    Lei Yin
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 318:1786-9. 2007
    ..Thus, Rev-erbalpha serves as a heme sensor that coordinates the cellular clock, glucose homeostasis, and energy metabolism...
  28. pmc Dual phase and rate coding in hippocampal place cells: theoretical significance and relationship to entorhinal grid cells
    John O'Keefe
    Department of Anatomy and Developmental Biology, University College London
    Hippocampus 15:853-66. 2005
    ..Finally, we propose a model of the firing of the recently discovered "grid cells" in entorhinal cortex as part of a path-integration system, in combination with place cells and head-direction cells...
  29. ncbi Melanopsin (Opn4) requirement for normal light-induced circadian phase shifting
    Satchidananda Panda
    Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA
    Science 298:2213-6. 2002
    ..However, they display severely attenuated phase resetting in response to brief pulses of monochromatic light, highlighting the critical role of melanopsin in circadian photoentrainment in mammals...
  30. pmc Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons
    Sara J Aton
    Department of Biology, One Brookings Drive, Washington University, St Louis, Missouri 63130, USA
    Nat Neurosci 8:476-83. 2005
    ..We conclude that VIP coordinates daily rhythms in the SCN and behavior by synchronizing a small population of pacemaking neurons and maintaining rhythmicity in a larger subset of neurons...
  31. pmc A genome-wide RNAi screen for modifiers of the circadian clock in human cells
    Eric E Zhang
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Cell 139:199-210. 2009
    ..Coupled with data showing many of these pathways are clock regulated, we conclude the clock is interconnected with many aspects of cellular function...
  32. ncbi double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation
    J L Price
    Laboratory of Genetics and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Cell 94:83-95. 1998
    ..This would promote a delay between per/tim transcription and PER/TIM complex function, which is essential for molecular rhythmicity...
  33. pmc Coupling governs entrainment range of circadian clocks
    Ute Abraham
    Laboratory of Chronobiology, Charite Universitatsmedizin Berlin, Berlin, Germany
    Mol Syst Biol 6:438. 2010
    ..These differences between master and the peripheral clocks suggest that coupling-induced rigidity in the SCN filters environmental noise to create a robust circadian system...
  34. ncbi Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog
    C Strayer
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 289:768-71. 2000
    ..TOC1 is itself circadianly regulated and participates in a feedback loop to control its own expression...
  35. ncbi Unexpected features of Drosophila circadian behavioural rhythms under natural conditions
    Stefano Vanin
    Department of Biology, University of Padova, Padova 35131, Italy
    Nature 484:371-5. 2012
    ..Such studies should also help to clarify the underlying molecular and neuroanatomical substrates of the clock under natural protocols...
  36. ncbi Synchronization of cellular clocks in the suprachiasmatic nucleus
    Shun Yamaguchi
    Division of Molecular Brain Science, Department of Brain Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Science 302:1408-12. 2003
    ..Na+-dependent action potentials contributed to establishing cellular synchrony and maintaining spontaneous oscillation across the SCN...
  37. ncbi Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage
    Antony N Dodd
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, CB2 3EA, UK
    Science 309:630-3. 2005
    ..This explains why plants gain advantage from circadian control...
  38. ncbi Role of melanopsin in circadian responses to light
    Norman F Ruby
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Science 298:2211-3. 2002
    ..Although melanopsin is not essential for the circadian clock to receive photic input, it contributes significantly to the magnitude of photic responses...
  39. ncbi Insect cryptochromes: gene duplication and loss define diverse ways to construct insect circadian clocks
    Quan Yuan
    Department of Neurobiology, University of Massachusetts Medical School, USA
    Mol Biol Evol 24:948-55. 2007
    ..These data provide an evolutionary context for proposing novel circadian clock mechanisms in insects...
  40. ncbi The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei
    Anthony J Harmar
    Department of Neuroscience, University of Edinburgh, 1 George Square, United Kingdom
    Cell 109:497-508. 2002
    ..Moreover, the mutants fail to show acute induction of mPer1 and mPer2 by nocturnal illumination. This study highlights the role of intercellular neuropeptidergic signaling in maintenance of circadian function within the SCN...
  41. ncbi Rhythmic histone acetylation underlies transcription in the mammalian circadian clock
    Jean Pierre Etchegaray
    Department of Neurobiology, University of Massachusetts Medical School, LRB 728, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nature 421:177-82. 2003
    ..The delayed timing of the Cry1 mRNA rhythm, relative to the Per rhythms, is due to the coordinated activities of Rev-Erbalpha and Clock/Bmal1, and defines a new mechanism for circadian phase control...
  42. ncbi Overlapping and distinct roles of PRR7 and PRR9 in the Arabidopsis circadian clock
    Eva M Farré
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Curr Biol 15:47-54. 2005
    ..We propose that the Arabidopsis circadian oscillator is composed of several interlocking positive and negative feedback loops, a feature of clock regulation that appears broadly conserved between plants, fungi, and animals...
  43. ncbi Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus
    Michelle Y Cheng
    Department of Pharmacology, University of California, Irvine, California 92697, USA
    Nature 417:405-10. 2002
    ..The high expression of PKR2 mRNA within the SCN and the positive feedback of PK2 on its own transcription through activation of PKR2 suggest that PK2 may also function locally within the SCN to synchronize output...
  44. pmc The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude
    Martha Hotz Vitaterna
    Center for Functional Genomics, Center for Sleep and Circadian Biology and Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208 3520, USA
    Proc Natl Acad Sci U S A 103:9327-32. 2006
    ..The increased efficacy of resetting stimuli and decreased PER expression amplitude can be explained in a unified manner by a model in which the Clock mutation reduces circadian pacemaker amplitude in the suprachiasmatic nuclei...
  45. ncbi Biological clocks and shift work: circadian dysregulation and potential long-term effects
    Erhard Haus
    Department of Laboratory Medicine and Pathology, University of Minnesota, Health Partners Medical Group, Regions Hospital, St Paul, Minnesota 55101, USA
    Cancer Causes Control 17:489-500. 2006
    ..The implications of the pathophysiology of phase shift are discussed for long-term health effects and for the design of ergonomic work schedules minimizing the adverse health effects upon the worker...
  46. ncbi Perisomatic feedback inhibition underlies cholinergically induced fast network oscillations in the rat hippocampus in vitro
    Edward O Mann
    University Laboratory of Physiology, Oxford University, Parks Road, Oxford OX1 3PT, UK
    Neuron 45:105-17. 2005
    ..AMPA receptor-mediated recurrent excitation was necessary for the synchronization of interneuronal discharge, which strongly supports a synaptic feedback model for the generation of hippocampal gamma oscillations...
  47. ncbi Molecular and functional heterogeneity of hyperpolarization-activated pacemaker channels in the mouse CNS
    B Santoro
    Center for Neurobiology and Behavior, Departments of Pharmacology and Anesthesiology, and Howard Hughes Medical Institute, Columbia University, New York, New York 10032, USA
    J Neurosci 20:5264-75. 2000
    ..Moreover, in some neurons, specific functional roles can be proposed for I(h) channels with defined subunit composition...
  48. ncbi Drosophila CRY is a deep brain circadian photoreceptor
    P Emery
    Department of Biology, National Science Foundation Center for Biological Timing, Waltham, Massachusetts 02454, USA
    Neuron 26:493-504. 2000
    ..These brain neurons therefore contain an identified deep brain photoreceptor, as well as the other circadian elements: a central pace-maker and a behavioral output system...
  49. ncbi An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome
    K L Toh
    Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Science 291:1040-3. 2001
    ..Thus, a variant in human sleep behavior can be attributed to a missense mutation in a clock component, hPER2, which alters the circadian period...
  50. ncbi Role of the CLOCK protein in the mammalian circadian mechanism
    N Gekakis
    Department of Neurobiology, Harvard Medical School, Boston MA 02115, USA 02115, USA
    Science 280:1564-9. 1998
    ..Thus, CLOCK-BMAL1 heterodimers appear to drive the positive component of per transcriptional oscillations, which are thought to underlie circadian rhythmicity...
  51. pmc Evolutionary plasticity of segmentation clock networks
    Aurélie J Krol
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Development 138:2783-92. 2011
    ..However, despite this conserved signaling oscillation, the identity of individual cyclic genes mostly differed between the three species, indicating a surprising evolutionary plasticity of the segmentation networks...
  52. pmc Characterization of orderly spatiotemporal patterns of clock gene activation in mammalian suprachiasmatic nucleus
    Nicholas C Foley
    Department of Cognitive and Neural Systems, Boston University, Boston, MA, USA
    Eur J Neurosci 33:1851-65. 2011
    ..We propose that serial activation of these subregions is the basis of robustness and resilience of the daily rhythm of the SCN...
  53. pmc Spontaneous synchronization of coupled circadian oscillators
    Didier Gonze
    Institute for Theoretical Biology, Humboldt Universitat zu Berlin, Berlin, Germany
    Biophys J 89:120-9. 2005
    ..However, due to the global neurotransmitter oscillation, cells are effectively synchronized...
  54. pmc Noise-induced coherence in multicellular circadian clocks
    Ekkehard Ullner
    Departament de Fisica i Enginyeria Nuclear, Universitat Politecnica de Catalunya, Terrassa, Spain
    Biophys J 96:3573-81. 2009
    ....
  55. pmc Neuregulin-1 modulates hippocampal gamma oscillations: implications for schizophrenia
    André Fisahn
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Cereb Cortex 19:612-8. 2009
    ..This study provides the first plausible link between NRG-1/ErbB4 signaling and rhythmic network activity that may be altered in persons with schizophrenia...
  56. ncbi A clock and wavefront mechanism for somite formation
    R E Baker
    Centre for Mathematical Biology, Mathematical Institute, 24 29 St Giles, Oxford OX1 3LB, UK
    Dev Biol 293:116-26. 2006
    ..We also show that the model can mimic the anomalies formed when progression of the wavefront is disturbed and make some experimental predictions that can be used to test the hypotheses underlying the model...
  57. pmc Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity
    S Hattar
    Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Science 295:1065-70. 2002
    ..Hence, melanopsin is most likely the visual pigment of phototransducing RGCs that set the circadian clock and initiate other non-image-forming visual functions...
  58. ncbi Intercellular coupling regulates the period of the segmentation clock
    Leah Herrgen
    Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Curr Biol 20:1244-53. 2010
    ..How this collective period is established is a key question in understanding biological clocks. We explore this question in the segmentation clock, a population of coupled cellular oscillators in the ..
  59. ncbi Resetting central and peripheral circadian oscillators in transgenic rats
    S Yamazaki
    NSF Center for Biological Timing and Department of Biology, University of Virginia, Charlottesville, VA 22903-2477, USA
    Science 288:682-5. 2000
    In multicellular organisms, circadian oscillators are organized into multitissue systems which function as biological clocks that regulate the activities of the organism in relation to environmental cycles and provide an internal ..
  60. pmc Phase-resetting curves determine synchronization, phase locking, and clustering in networks of neural oscillators
    Srisairam Achuthan
    Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci 29:5218-33. 2009
    ..These results can be used to gain insights into the activity of networks of biological neurons whose PRCs can be measured...
  61. ncbi Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections
    E E Abrahamson
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Brain Res 916:172-91. 2001
    ..The organization of the mouse SCN, and its connections, are similar to that in other mammalian species...
  62. pmc A multi-cell, multi-scale model of vertebrate segmentation and somite formation
    Susan D Hester
    Biocomplexity Institute and Department of Physics, Indiana University Bloomington, Bloomington, Indiana, United States of America
    PLoS Comput Biol 7:e1002155. 2011
    ....
  63. pmc A loss of parvalbumin-containing interneurons is associated with diminished oscillatory activity in an animal model of schizophrenia
    Daniel J Lodge
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 29:2344-54. 2009
    ..Such information is central to gaining a better understanding of the disease pathophysiology and alternate pharmacotherapeutic approaches...
  64. pmc Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins
    Qing Jun Meng
    Faculty of Life Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Neuron 58:78-88. 2008
    ....
  65. ncbi Existing motor state is favored at the expense of new movement during 13-35 Hz oscillatory synchrony in the human corticospinal system
    Thomas Gilbertson
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 25:7771-9. 2005
    ..The findings are of relevance to Parkinson's disease, in which subcortical and cortical beta-band synchronization is exaggerated in the setting of increased tone and slowed movements...
  66. ncbi Spike timing of distinct types of GABAergic interneuron during hippocampal gamma oscillations in vitro
    Norbert Hajos
    Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H 1450, Hungary
    J Neurosci 24:9127-37. 2004
    ....
  67. ncbi vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock
    Shawn A Cyran
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Cell 112:329-41. 2003
    ..Thus, VRI and PDP1, together with dClock itself, comprise a second feedback loop in the Drosophila clock that gives rhythmic expression of dClock, and probably of other genes, to generate accurate circadian rhythms...
  68. pmc Intronic delay is essential for oscillatory expression in the segmentation clock
    Yoshiki Takashima
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 108:3300-5. 2011
    ..These results indicate that introns are indeed required for Hes7 oscillations and point to the significance of intronic delays in dynamic gene expression...
  69. ncbi Temporal dynamics of mouse hippocampal clock gene expression support memory processing
    Antje Jilg
    Institute of Cellular and Molecular Anatomy, Dr Senckenbergische Anatomie, Goethe University, Frankfurt, Germany
    Hippocampus 20:377-88. 2010
    ..We propose that the dynamics of hippocampal clock gene expression imprint a temporal structure on memory processing and shape at the same time the efficacy of behavioral learning...
  70. ncbi Temporal precision in the mammalian circadian system: a reliable clock from less reliable neurons
    Erik D Herzog
    Department of Biology, Washington University, St Louis, MO 63130, USA
    J Biol Rhythms 19:35-46. 2004
    ..These results indicate that cell-cell interactions within the SCN reduce pacemaker noise to determine the precision of circadian rhythms in the tissue and in behavior...
  71. ncbi Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease
    P Brown
    Medical Research Council Human Movement and Balance Unit, Institute of Neurology, London WCIN 3BG, United Kingdom
    J Neurosci 21:1033-8. 2001
    ..Synchronization of activity does occur between pallidum and STN, and its pattern is critically dependent on the level of dopaminergic activity...
  72. pmc Interfering with Wnt signalling alters the periodicity of the segmentation clock
    Sarah Gibb
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland, UK
    Dev Biol 330:21-31. 2009
    ..We propose that the Wnt pathway is a conserved mechanism that is involved in regulating the period of cyclic gene oscillations in the presomitic mesoderm...
  73. ncbi Constitutive expression of the CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) gene disrupts circadian rhythms and suppresses its own expression
    Z Y Wang
    Department of Molecular, Cell, and Developmental Biology, UCLA, Los Angeles, California 90095 1606, USA
    Cell 93:1207-17. 1998
    ..Furthermore, the expression of both endogenous CCA1 and the related LHY gene was suppressed. Our results suggest that CCA1 is a part of a feedback loop that is closely associated with the circadian clock in Arabidopsis...
  74. pmc Small-world network models of intercellular coupling predict enhanced synchronization in the suprachiasmatic nucleus
    Christina Vasalou
    Department of Chemical Engineering, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Biol Rhythms 24:243-54. 2009
    ..This model predicts that small decreases in long-range VIP connections in the SCN could have dramatic effects on period and amplitude of daily rhythms, features commonly described with aging...
  75. pmc Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing
    Jordi Garcia-Ojalvo
    Center for Applied Mathematics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 101:10955-60. 2004
    ..As such, the particular system of coupled genetic oscillators considered here might be a good candidate to provide the first quantitative example of a synchronization transition in a population of biological oscillators...
  76. pmc Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression
    Sandra M Siepka
    Howard Hughes Medical Institute, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Cell 129:1011-23. 2007
    ..Thus, Fbxl3(Ovtm) defines a molecular link between CRY turnover and CLOCK/BMAL1-dependent circadian transcription to modulate circadian period...
  77. ncbi Food-anticipatory circadian rhythms: concepts and methods
    Ralph E Mistlberger
    Department of Psychology, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada
    Eur J Neurosci 30:1718-29. 2009
    ....
  78. ncbi Circadian rhythms: mechanisms and therapeutic implications
    Francis Levi
    INSERM U776, Unité de Chronothérapie, Service de cancérologie, Hôpital Paul Brousse et Université Paris XI, 94800 Villejuif, France
    Annu Rev Pharmacol Toxicol 47:593-628. 2007
    ..This knowledge can in turn be used in improving or designing chronotherapeutics for the patients who suffer from many of the major human diseases...
  79. pmc Circadian organization of behavior and physiology in Drosophila
    Ravi Allada
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Annu Rev Physiol 72:605-24. 2010
    ..These studies reveal a remarkable complexity to circadian pathways in this "simple" model organism...
  80. ncbi A role for CK2 in the Drosophila circadian oscillator
    Bikem Akten
    Department of Neuroscience, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 01211, USA
    Nat Neurosci 6:251-7. 2003
    ..These results suggest a function for CK2-dependent phosphorylation in the molecular oscillator...
  81. pmc Stomach ghrelin-secreting cells as food-entrainable circadian clocks
    Joseph LeSauter
    Department of Psychology, Barnard College, 3009 Broadway, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 106:13582-7. 2009
    ..It is likely that other FEOs also produce humoral signals that modulate FAA...
  82. ncbi A role for the segment polarity gene shaggy/GSK-3 in the Drosophila circadian clock
    S Martinek
    Laboratory of Genetics and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, NY 10021, USA
    Cell 105:769-79. 2001
    ..Our results indicate a role for SGG/GSK-3 in TIMELESS phosphorylation and in the regulated nuclear translocation of the PERIOD/TIMELESS heterodimer...
  83. ncbi A clock shock: mouse CLOCK is not required for circadian oscillator function
    Jason P Debruyne
    Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Neuron 50:465-77. 2006
    ..Our data challenge a central feature of the current mammalian circadian clock model regarding the necessity of CLOCK:BMAL1 heterodimers for clock function...
  84. pmc Circadian control of the daily plasma glucose rhythm: an interplay of GABA and glutamate
    Andries Kalsbeek
    Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
    PLoS ONE 3:e3194. 2008
    ....
  85. ncbi Multiple signaling pathways elicit circadian gene expression in cultured Rat-1 fibroblasts
    A Balsalobre
    , Sciences II, , Switzerland
    Curr Biol 10:1291-4. 2000
    ..We thus suspect that the SCN pacemaker may exploit multiple chemical cues to synchronize peripheral oscillators in vivo...
  86. pmc Robust, tunable biological oscillations from interlinked positive and negative feedback loops
    Tony Yu Chen Tsai
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Science 321:126-9. 2008
    ..Positive-plus-negative oscillators also appear to be more robust and easier to evolve, rationalizing why they are found in contexts where an adjustable frequency is unimportant...
  87. pmc Separate oscillating cell groups in mouse suprachiasmatic nucleus couple photoperiodically to the onset and end of daily activity
    Natsuko Inagaki
    Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Proc Natl Acad Sci U S A 104:7664-9. 2007
    ..These findings indicate that three oscillating cell groups in the SCN constitute regionally specific circadian oscillations, and at least two of them are involved in photoperiodic response of behavioral rhythm...
  88. ncbi Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation
    N J Ray
    Department of Anatomy, Physiology and Genetics, University of Oxford, Parks Road, OX1 3PT, USA
    Exp Neurol 213:108-13. 2008
    ....
  89. pmc Looking for inspiration: new perspectives on respiratory rhythm
    Jack L Feldman
    Department of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles, Box 951763, Los Angeles, California 90095 1763, USA
    Nat Rev Neurosci 7:232-42. 2006
    ..Lesion studies suggest that respiratory cell death might explain morbidity and mortality associated with neurodegenerative disorders and ageing...
  90. pmc Parvalbumin-containing fast-spiking basket cells generate the field potential oscillations induced by cholinergic receptor activation in the hippocampus
    Attila I Gulyás
    Institute of Experimental Medicine, Hungarian Academy of Sciences, H 1083 Budapest, Hungary
    J Neurosci 30:15134-45. 2010
    ..These results collectively suggest that the rhythmic perisomatic inhibition, generating oscillatory fluctuation in local field potentials after carbachol treatment of hippocampal slices, is the result of periodic GABA release from FSBCs...
  91. ncbi Precise long-range synchronization of activity and silence in neocortical neurons during slow-wave oscillations [corrected]
    Maxim Volgushev
    Department of Neurophysiology, Ruhr University Bochum, D 44780 Bochum, Germany
    J Neurosci 26:5665-72. 2006
    ..Revealing this yet unknown large-scale mechanism, which switches network activity to silence, will aid our understanding of the origin of brain rhythms in normal function and pathology...
  92. ncbi Reciprocal regulation of haem biosynthesis and the circadian clock in mammals
    Krista Kaasik
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 430:467-71. 2004
    ..Our data show that the circadian clock and haem biosynthesis are reciprocally regulated and suggest that porphyrin-containing molecules are potential targets for therapy of circadian disorders...
  93. ncbi Forty years of PRCs--what have we learned?
    C H Johnson
    Department of Biology, Vanderbilt University, Nashville, TN 37235, USA
    Chronobiol Int 16:711-43. 1999
    ..PRCs have enlightened us and will continue to be a valuable tool in clock research...
  94. ncbi Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain
    B Santoro
    Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Cell 93:717-29. 1998
    ....
  95. ncbi Reciprocal regulation between TOC1 and LHY/CCA1 within the Arabidopsis circadian clock
    D Alabadi
    Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, CA 92037, USA
    Science 293:880-3. 2001
    ..Conversely, TOC1 appears to participate in the positive regulation of LHY and CCA1 expression. Our results indicate that these interactions form a loop critical for clock function in Arabidopsis...
  96. pmc The meter of metabolism
    Carla B Green
    Department of Biology, University of Virginia, Charlottesville, VA 22904, USA
    Cell 134:728-42. 2008
    ..Here, we review the relationship between the circadian and metabolic systems and the implications for cardiovascular disease, obesity, and diabetes...
  97. ncbi FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation
    J Dubrulle
    , Developmental Biology Institute of Marseille (IBDM, , Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Cell 106:219-32. 2001
    ..These results implicate FGF8 in ensuring tight coordination of the segmentation process and spatiotemporal Hox gene activation...
  98. ncbi Modeling the segmentation clock as a network of coupled oscillations in the Notch, Wnt and FGF signaling pathways
    Albert Goldbeter
    Faculte des Sciences, Universite Libre de Bruxelles, Campus Plaine, C P 231, B 1050 Brussels, Belgium
    J Theor Biol 252:574-85. 2008
    ..The model provides a framework for analyzing the dynamics of the segmentation clock in terms of a network of oscillating modules involving the Wnt, Notch and FGF signaling pathways...
  99. ncbi Building a cell cycle oscillator: hysteresis and bistability in the activation of Cdc2
    Joseph R Pomerening
    Department of Molecular Pharmacology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Nat Cell Biol 5:346-51. 2003
    ..We also show that Cdc2 activation exhibits hysteresis, a property of bistable systems with particular relevance to biochemical oscillators. These findings help establish the basic systems-level logic of the mitotic oscillator...
  100. ncbi Circadian rhythms from flies to human
    Satchidananda Panda
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 417:329-35. 2002
    ..To gain the initial insights into circadian mechanisms, researchers turned to genetically tractable model organisms such as Drosophila...
  101. ncbi Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
    Yasukazu Nakahata
    Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Science 324:654-7. 2009
    ..Our findings in mouse embryo fibroblasts reveal an interlocked transcriptional-enzymatic feedback loop that governs the molecular interplay between cellular metabolism and circadian rhythms...

Research Grants63

  1. Photoperiod Brain and Behavior
    Randy J Nelson; Fiscal Year: 2012
    ..memory performance as adaptations due to changing energetic conditions that are dependent on photoperiod, biological clocks, and melatonin...
  2. Circadian Expression of Procolipase in the Liver: A Metabolic Signal
    Mark E Lowe; Fiscal Year: 2010
    ..The proposed studies have the potential to open new avenues in the treatment of obesity through modulating the effects of the environment on biological clocks.
  3. Circadian Programs in Bacteria
    Carl Hirschie Johnson; Fiscal Year: 2013
    ..b>Biological clocks have been found to be crucial for physical and mental health;cancer, metabolic disorders, cardiovascular ..
  4. Circadian Regulation of Gonadotropin-Releasing Hormone
    Patrick E Chappell; Fiscal Year: 2010
    ..While previous studies implicate 24-hour biological clocks in both mechanisms of reproductive hormone secretion, it is unknown how circadian clocks might act within ..
  5. Biological Rhythms and Immune Function
    Brian J Prendergast; Fiscal Year: 2013
    ..Understanding how biological clocks engage changes in the immune system has implications for the treatment and management of chronic diseases (e...
  6. Structure and Function of Circadian Clock Light Sensors
    Brian R Crane; Fiscal Year: 2013
    ..In humans, our biological clocks impact many aspects of our physiology, including sleep, mental well-being, and the prevention and treatment ..
  7. COORDINATION OF CIRCADIAN PHYSIOLOGY OF DIVERSE SPECIES
    Deborah Bell Pedersen; Fiscal Year: 2010
    ..organisms? Lay summary: This research will lead the way to a comprehensive systems biology approach to biological clocks that will elucidate chronobiological disorders associated with sleep and wakefulness, many of which are ..
  8. Structural Biology of the S. elongatus Circadian Clock
    Martin Egli; Fiscal Year: 2013
    ..protein KaiC will be probed using a combined mutagenic, functional and hybrid structural (X-ray, EM, SAXS, SANS) approach and the molecular origins of temperature compensation, a hallmark of all biological clocks will be determined.
  9. Circadian Clock Gene Polymorphisms Associated with Depression
    Carl Hirschie Johnson; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: This project will use genetic techniques to study the relationship between daily biological clocks and depression in humans...
  10. Analysis of EGFR-dependent sleep in C. elegans
    CHERYL LYNN VAN BUSKIRK; Fiscal Year: 2013
    ..This analysis is relevant to the regulation of sleep by biological clocks in mammals, as the molting cycle is regulated by the C. elegans homolog of the circadian gene PER...
  11. CELL BIOLOGY OF CIRCADIAN SIGNALING MECHANISMS
    Steve A Kay; Fiscal Year: 2013
    Description (provided by applicant): Our endogenous biological clocks control many key aspects of human physiology and behavior...
  12. Experimental Evolution of Circadian Oscillators
    Carl Hirschie Johnson; Fiscal Year: 2012
    ..The successful evolution of such oscillators will be assessed with luminescence reporters of cell cycle and metabolic events. ..
  13. Tissue-engineered Autonomous Pacemaker
    Nenad Bursac; Fiscal Year: 2012
    ..The goal of this exploratory proposal is to establish tissue and genetic engineering rules that would enable generation of stable autonomous biopacemaking tissues starting from electrically unexcitable cells. ..
  14. From human keratinocytes to biological pacemakers
    Ira S Cohen; Fiscal Year: 2013
    ..If the HFKT-pacemaker functions well in the canine heart, a future goal would be to advance this novel autologous, cellular approach towards clinical deployment. ..
  15. BLUE-LIGHT PHOTORECEPTOR GENES IN CHLAMYDOMONAS
    Gary Small; Fiscal Year: 1999
    ..In humans, blue-light may be involved in setting the biological clocks or circadian rhythms...
  16. CASE CONTROL STUDY OF INSOMNIA IN NONDEPRESSED ELDERLY
    Allan Pack; Fiscal Year: 2001
    ....
  17. Arylhydrocarbon receptor in resistance to listeriosis
    Charles Czuprynski; Fiscal Year: 2006
    ..g. benzo[a]pyrene). In invertebrates the AhR is involved in environmental sensing, regulation of biological clocks and normal development, and it retains some of these functions within vertebrates...
  18. BRET INTERACTION SYSTEM FOR CIRCADIAN AND OTHER PROTEINS
    Carl Johnson; Fiscal Year: 2001
    ..We will apply this method to our topic of primary research interest, "biological clocks," and to general applications for the determination of protein-protein interactions within cells and ..
  19. 12th FASEB Summer Research Conference on Retinoids
    WILLIAM BLANER; Fiscal Year: 2004
    ..This will stimulate new investigations that in time will provide needed insight into the essential actions of retinoids in preventing disease and maintaining good health. ..
  20. MOLECULAR/GENETIC ANALYSIS OF BIOLOGICAL CLOCKS IN CELLS
    Carl Johnson; Fiscal Year: 2005
    ..These "biological clocks" are important to human physiology...
  21. INPUT/OUTPUT ANALYSIS OF CELLULAR CIRCADIAN RHYTHMS
    Carl Johnson; Fiscal Year: 1992
    ..These "biological clocks" are important to human physiology...
  22. MODEL TO STUDY THE ROLE OF AVP, PKC, AND FOS IN THE SCN
    Abel Bult Ito; Fiscal Year: 2000
    DESCRIPTION (Adapted from applicant's abstract): The suprachiasmatic nuclei (SCN) are the major "biological clocks" in mammals and control most circadian rhythms expressed by the animal...
  23. Cold Spring Harbor 72nd Symposiumon Quantitative Biology: Clocks & Rhythms
    David Stewart; Fiscal Year: 2007
    ..The meeting will address the phenomenon of biological clocks and their function and dysfunction in a variety of cells, tissues and organisms...
  24. Circadian control of a behavioral output
    John Ewer; Fiscal Year: 2007
    ..Thus it offers a unique opportunity to elucidate how the activity of the clock is coupled to the mechanism that controls a behavioral output. [unreadable] [unreadable] [unreadable]..
  25. PRECURSOR CELL RENEWAL, OLIGODENDROCYTES & REMYELINATION
    Mark Noble; Fiscal Year: 2001
    ..ii) determining their biological relationship with each other (iii) establishing contributions of intrinsic biological clocks to modulating differentiation and limiting self renewal (iv) identifying growth conditions that override ..
  26. PHYSIOLOGY OF CIRCADIAN SYSTEMS
    Herbert Underwood; Fiscal Year: 2000
    ..These studies will focus on three areas which can act as biological clocks in vertebrates - the pineal organ, the suprachiasmatic nuclei of the hypothalamus, and the eyes...
  27. BEHAVIOR, BIOLOGICAL CLOCKS AND HORMONES
    LAWRENCE MORIN; Fiscal Year: 1980
    ....
  28. AMERICAN MOTILITY SOCIETY--BIOLOGICAL OSCILLATORS
    Nicholas Diamant; Fiscal Year: 1990
    ..the membership to nationally and internationally recognized experts in the field of excitable membranes and biological clocks. The Symposium is designed to extend the information base established by symposia on Regulation of Smooth ..
  29. CENTRAL NEURAL PROCESSING OF CIRCADIAN INFORMATION
    Michael Roberts; Fiscal Year: 1992
    ..These rhythms are controlled by biological clocks: circadian pacemakers, localized to restricted portions of the neuroendocrine system, which act to time many ..
  30. CELLULAR AND MOLECULAR BASES FOR RHYTHMIC GNRH RELEASE
    SUZANNE MOENTER; Fiscal Year: 2001
    ..Specific Aim IV will examine the mechanisms coordinating GnRH release, addressing the hypothesis that GnRH serves as a neuromediator coordinating its own release. ..
  31. Mechanistic Determinants of Pacing-induced Cardiac Memory
    Michael R Rosen; Fiscal Year: 2010
    ..Rather than being reductionist, the approach attempts to synthesize information so that we can better comprehend and impact on a clinically important problem. ..
  32. ATRIAL FIBRILLATION: MECHANISMS AND PREVENTION
    Michael Rosen; Fiscal Year: 2003
    ....
  33. Cardiovascular Development and Disease in the Young
    Michael Rosen; Fiscal Year: 2008
    ..abstract_text> ..
  34. CENTRAL NEURAL CONTROL OF CARDIOVASCULAR FUNCTION
    GERARD GEBBER; Fiscal Year: 2002
    ..The above listed hypotheses will be tested by examining the interrelations of these signals using computational methods including spike-triggered averaging, phase plane, ordinary and partial coherence and bicoherence analyses. ..
  35. Eleventh Meeting of the Society for Research on Biological Rhythms
    Ravi Allada; Fiscal Year: 2008
    ..The research presented at the 11th meeting of the Society for Research on Biological Rhythms investigates these links, and could ultimately lead to better diagnostics and therapeutics. [unreadable] [unreadable] [unreadable]..
  36. Function of the Novel Ion Channel narrow abdomen in Daily Rhythms
    Ravi Allada; Fiscal Year: 2008
    ..Given the conservation of clocks and NA, this proposal should illuminate human daily rhythms and their contribution to disease. ..
  37. Chronobiology of alcohol: animal models
    ALAN ROSENWASSER; Fiscal Year: 2006
    ..The results of these studies will contribute substantially to understanding both the causes and the consequences of sleep and circadian rhythm disruptions occurring in human alcoholics. ..
  38. Mouse Mutagenesis: Phenotype-Driven Neuroscience Screens
    JOSEPH TAKAHASHI; Fiscal Year: 2005
    ..Phenotype-driven mutagenesis screens provide an important approach to understand the function of these genes. ..
  39. A Spiking Model of Hippocampus for Guiding Behavior
    Michael Hasselmo; Fiscal Year: 2006
    ..U., which focuses on modeling operant tasks used in experimental studies of drug self-administration phenomena, in work supported by a supplement to a previous grant from NIDA. [unreadable] [unreadable]..
  40. IDENTIFICATION AND ANALYSIS OF CLOCK CONTROLLED GENES
    Jennifer Loros; Fiscal Year: 2007
    ..These approaches will be illuminated by the insights afforded through our work with both a simple eukaryotic model system and a mammalian cell culture model of the clock. ..
  41. 2007 Chronobiology Gordon Research Conference
    JOSEPH TAKAHASHI; Fiscal Year: 2007
    ..Outcomes will have health relevance for ameliorating dysfunctions that manifest as sleep, affective, cognitive, neurological, metabolic, endocrine and oncological disorders and occupational health. [unreadable] [unreadable] [unreadable]..
  42. Function of Casein Kinase 2 in the Circadian Clock
    Ravi Allada; Fiscal Year: 2007
    Daily rhythms and behavior are driven in part by biological clocks. Clinical studies suggest that circadian rhythm defects contribute to certain forms of depression and sleep disorders...
  43. GENETIC AND MOLECULAR DISSECTION OF THE NEUROSPORA CLOCK
    Jay Dunlap; Fiscal Year: 2007
    ..the organization of the cells as a function of time.[unreadable]..
  44. CIRCADIAN REGULATORY CIRCUITS IN DROSOPHILA
    Paul Hardin; Fiscal Year: 2008
    ..Since the feedback loop mechanism has been conserved between flies and mammals, what we learn here will be relevant to the situation in mammals. ..
  45. Biosensor for Contaminant-Free Platelets
    Edward Elson; Fiscal Year: 2002
    ..abstract_text> ..
  46. DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUM
    DALTON SURMEIER; Fiscal Year: 2007
    ....
  47. WINTER CONFERENCE ON BRAIN RESEARCH
    DALTON SURMEIER; Fiscal Year: 2005
    ..Particular emphasis will be placed on obtaining a diverse group of fellows with respect to parent institution, gender, and minority status. ..
  48. A Dual Transcriptional and High Content Assay for Cryptochrome
    John Hogenesch; Fiscal Year: 2006
    ..Thus, successful completion of the proposed research would provide a tool to address an important scientific question, as well as lay the groundwork for mechanism-based perturbation of the clock. ..
  49. Early Randomized Surgical Epilepsy Trial
    Jerome Engel; Fiscal Year: 2007
    ..abstract_text> ..
  50. Photic and Circadian Regulation of Retinal Melatonin
    Gianluca Tosini; Fiscal Year: 2010
    ..Modern life style has tremendously changed the time at which we expose ourselves to light;hence, it is important to understand the effect that such exposure may have on retinal physiology and pathology. ..
  51. MECHANISMS OF LONG-TERM POTENTIATION
    John E Lisman; Fiscal Year: 2010
    ..Positive results would strongly argue that the CaMKII-NMDA complex is critical for the storage of synaptic memory and would set the stage for studying the role of this complex in the maintenance of behavioral memory. ..
  52. MOLECULAR/GENETIC ANALYSIS OF BIOLOGICAL CLOCKS
    Carl Johnson; Fiscal Year: 2003
    This research concerns daily biological clocks, which are an important component of the physiology of humans and other organisms...
  53. Comprehensive Laboratory Animal Monitoring System
    Martin Young; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  54. Third International Neural Engineering Conference 2007
    Metin Akay; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  55. Novel ratiometric luminescence reporters for intracellular free calcium
    Carl Johnson; Fiscal Year: 2008
    ..of luminescent Ca++ probes, the use of these reporters will be applied to the study of Ca++-fluxes in biological clocks (circadian rhythms)...
  56. CRCNS-Multiple olfactory gamma oscillations: roles in sensation and attention
    Leslie Kay; Fiscal Year: 2008
    ..We anticipate that understanding how olfactory deficits arise from changes in the limbic system associated with many of these disorders, will help us to understand the mechanisms that produce cognitive malfunctioning. ..
  57. Nutritional manipulation of circadian rhythms and cancer
    Alec Davidson; Fiscal Year: 2007
    ..The experiments will form the basis for future study of circadian and nutritional influences on development of this and other cancers. [unreadable] [unreadable] [unreadable]..
  58. Database of Functional SNPs in Cancer-Related Environmentally Responsive Genes
    Yong Zhu; Fiscal Year: 2009
    ..Findings from this study will enhance the use of SNPs in future phenotypic studies and molecular epidemiologic approaches to address questions related to gene-environment interaction in disease risk estimate. ..
  59. Toxin Detection w/Antibody Fragments & Novel Biosensors
    Edward Elson; Fiscal Year: 2003
    ..We will also compare each system to standard ELISA. ..
  60. MONOAMINERGIC MODULATION OF PREFRONTAL CORTEX
    DALTON SURMEIER; Fiscal Year: 2004
    ..Achieving these specific aims will provide the molecular and cellular framework necessary to begin building an accurate, integrative model of PFC function and dysfunction in schizophrenia. ..
  61. CIRCADIAN REGULATORY CIRCUITS IN DROSOPHILA
    Paul Hardin; Fiscal Year: 2003
    ..1) identifying the factor(s) responsible for dClk activation, 2) determining how dCLK and CYC repress dClk transcription and 3) determining whether PER-TIM interactions with dCLK-CYC are capable of de-repressing dClk transcription. ..
  62. The Immune Response in Mast Cell Deficient Mice
    Rae Silver; Fiscal Year: 2005
    ..This application will determine whether mast cells play a role in mounting an immune response in the brain. ..