receptor cross talk

Summary

Summary: The simultaneous or sequential binding of multiple cell surface receptors to different ligands resulting in coordinated stimulation or suppression of signal transduction.

Top Publications

  1. ncbi Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor
    Belinda E Peace
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Exp Cell Res 289:317-25. 2003
  2. ncbi Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes
    Carmine Morisco
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Napoli, Italy
    Circ Res 96:180-8. 2005
  3. ncbi GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways
    Stefan Hart
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Biol Chem 386:845-55. 2005
  4. ncbi Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
    Rita Nahta
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer Res 65:11118-28. 2005
  5. pmc Estrogen action and cytoplasmic signaling pathways. Part II: the role of growth factors and phosphorylation in estrogen signaling
    Paul H Driggers
    Dept of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD, USA
    Trends Endocrinol Metab 13:422-7. 2002
  6. pmc HMGB1-dependent triggering of HIV-1 replication and persistence in dendritic cells as a consequence of NK-DC cross-talk
    Hela Saidi
    Institut Pasteur, Antiviral Immunity, Biotherapy and Vaccine Unit, Inserm U668, Paris, France
    PLoS ONE 3:e3601. 2008
  7. ncbi Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk
    Qi Zhu
    Shanghai Institute of Hematology and Key Laboratory for Human Genome Research, Rui Jin Hospital, Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, P R China
    Blood 99:1014-22. 2002
  8. ncbi Specificity, diversity, and convergence in VEGF and TNF-alpha signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells
    D Mechtcheriakova
    Department of Vascular Biology and Thrombosis Research, VIRCC, University of Vienna, A-1235 Vienna, Austria
    FASEB J 15:230-242. 2001
  9. ncbi A global analysis of cross-talk in a mammalian cellular signalling network
    Madhusudan Natarajan
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9050, USA
    Nat Cell Biol 8:571-80. 2006
  10. ncbi Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains
    A Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Science 288:2357-60. 2000

Research Grants

  1. PERINATAL METABOLIC AND HORMONAL EFFECTS
    Sherin U Devaskar; Fiscal Year: 2010
  2. Cell Priming, Receptor Cross-talk and Acute Lung Injury
    Mark A Wilson; Fiscal Year: 2013
  3. Mechanisms of Herceptin resistance
    Rita Nahta; Fiscal Year: 2013
  4. Receptor Tyrosine Kinases: Biology and Cancer
    Jonathan A Cooper; Fiscal Year: 2010
  5. Receptor Cross-Talk in Early Metastatic Dissemination
    MARY SHARON STACK; Fiscal Year: 2013
  6. SPERM GLYCINE RECEPTORS AND ZONA-INITIATED EXOCYTOSIS
    Stanley Meizel; Fiscal Year: 2006
  7. CD3 e functions in T cells
    NICOLAI VAN OERS; Fiscal Year: 2009
  8. AUTONOMIC MUSCARINIC RECEPTOR SIGNALING MECHANISMS
    FRED EHLERT; Fiscal Year: 2000
  9. Coexpression of EGFRvlll/ErbB2 in Human Breast Cancer
    Careen Tang; Fiscal Year: 2005
  10. Chemoreception and Signal Amplification
    MICHAEL MANSON; Fiscal Year: 2005

Detail Information

Publications226 found, 100 shown here

  1. ncbi Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor
    Belinda E Peace
    Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Exp Cell Res 289:317-25. 2003
    ..This novel finding of a functional and biochemical interaction between Ron and EGFR suggests that heterologous tyrosine kinase receptor interactions may play a role in cellular processes such as scatter and transformation...
  2. ncbi Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes
    Carmine Morisco
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Napoli, Italy
    Circ Res 96:180-8. 2005
    ....
  3. ncbi GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways
    Stefan Hart
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Biol Chem 386:845-55. 2005
    ..We conclude that GPCR-induced chemotaxis of breast cancer cells is mediated by EGFR-dependent and -independent signalling pathways, with both parallel pathways having to act in concert to achieve a complete migratory response...
  4. ncbi Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
    Rita Nahta
    Department of Breast Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer Res 65:11118-28. 2005
    ....
  5. pmc Estrogen action and cytoplasmic signaling pathways. Part II: the role of growth factors and phosphorylation in estrogen signaling
    Paul H Driggers
    Dept of Obstetrics and Gynecology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD, USA
    Trends Endocrinol Metab 13:422-7. 2002
    ..These signaling pathways regulate important physiological processes, such as cell growth and apoptosis. Here, we focus on cytoplasmic signaling pathways leading to activation of ERs...
  6. pmc HMGB1-dependent triggering of HIV-1 replication and persistence in dendritic cells as a consequence of NK-DC cross-talk
    Hela Saidi
    Institut Pasteur, Antiviral Immunity, Biotherapy and Vaccine Unit, Inserm U668, Paris, France
    PLoS ONE 3:e3601. 2008
    ..Here, we investigate the impact of NK-DC cross-talk on maturation and functions of HIV-infected immature DCs...
  7. ncbi Synergic effects of arsenic trioxide and cAMP during acute promyelocytic leukemia cell maturation subtends a novel signaling cross-talk
    Qi Zhu
    Shanghai Institute of Hematology and Key Laboratory for Human Genome Research, Rui Jin Hospital, Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, P R China
    Blood 99:1014-22. 2002
    ..These results thus support the existence of a novel signaling cross-talk for APL maturation, which may deepen understanding of As(2)O(3)-induced differentiation in vivo, and thus furnish insights for new therapeutic strategies...
  8. ncbi Specificity, diversity, and convergence in VEGF and TNF-alpha signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells
    D Mechtcheriakova
    Department of Vascular Biology and Thrombosis Research, VIRCC, University of Vienna, A-1235 Vienna, Austria
    FASEB J 15:230-242. 2001
    ..The additional finding that EGF induces ERK and EGR-1 in a PKC-independent manner and that this signal is not sufficient to up-regulate TF emphasizes the importance of a VEGF-specific signaling pattern for the induction of TF...
  9. ncbi A global analysis of cross-talk in a mammalian cellular signalling network
    Madhusudan Natarajan
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9050, USA
    Nat Cell Biol 8:571-80. 2006
    ..A global analysis of cross-talk suggests that many external stimuli converge on a relatively small number of interaction mechanisms to provide for context-dependent signalling...
  10. ncbi Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains
    A Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Science 288:2357-60. 2000
    ..This aspect of signaling cross talk by IFNs may apply to other cytokines...
  11. ncbi The role of growth factor receptor pathways in human breast cancer cells adapted to long-term estrogen deprivation
    Gauri J Sabnis
    Department of Pharmacology and Experimental Therapeutics, University of Maryland Baltimore, Baltimore, Maryland 21201, USA
    Cancer Res 65:3903-10. 2005
    ..Cross-talk between ER and growth factor signaling was evident as inhibition of these pathways could restore estrogen responsiveness to these cells...
  12. ncbi ERE-independent ERalpha target genes differentially expressed in human breast tumors
    Christine Glidewell-Kenney
    Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University, Feinberg School of Medicine, 251 E Huron Street, Galter Pavilion Suite 3 150, Chicago, IL 60611, USA
    Mol Cell Endocrinol 245:53-9. 2005
    ..The identification of nonclassical ERalpha target genes offers new insight into estrogen receptor signaling and cross talk with pathways that mediate breast tumor response to SERM therapy...
  13. pmc A comprehensive map of the toll-like receptor signaling network
    Kanae Oda
    The Systems Biology Institute, Shibuya, Tokyo, Japan
    Mol Syst Biol 2:2006.0015. 2006
    ....
  14. pmc Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation
    Y Saito
    Center for Cardiovascular Research, University of Rochester, Rochester, New York 14642, USA
    Mol Cell Biol 21:6387-94. 2001
    ..In conclusion, our data demonstrate that the PDGFbetaR and the EGFR form PDGFbetaR-EGFR heterodimers basally, and we suggest that heterodimers represent a novel signaling complex which plays an important role in PDGF signal transduction...
  15. ncbi Microparticles as mediators of cellular cross-talk in inflammatory disease
    Jörg H W Distler
    Department of Internal Medicine 3, University of Erlangen, Erlangen, Germany
    Autoimmunity 39:683-90. 2006
    ..Together, these findings point to novel signaling pathways of cellular cross-talk that may operate along the spectrum of soluble cytokines and mediators of direct cell-cell contact...
  16. ncbi Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer
    Jiang Shou
    The Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    J Natl Cancer Inst 96:926-35. 2004
    ..We used a breast cancer model system with high expression of AIB1 and HER2 to investigate the possible mechanisms underlying this resistance...
  17. ncbi Signal integration by JNK and p38 MAPK pathways in cancer development
    Erwin F Wagner
    Centro Nacional de Investigaciones Oncologicas, C Melchor Fernandez Almagro 3, Madrid 28029, Spain
    Nat Rev Cancer 9:537-49. 2009
    ..In this Review we highlight the recent progress made in defining the functions of the JNK and p38 MAPK pathways in different cancers...
  18. ncbi Crosstalk between IGF signaling and steroid hormone receptors in breast cancer
    Diego Sisci
    Department of Pharmaco Biology, University of Calabria, Arcavacata di Rende CS 87036
    Curr Pharm Des 13:705-17. 2007
    ..In turn, the expression of growth factor receptors, their ligands, and signaling molecules is often controlled by SHs. This review will focus on crosstalk between the IGF-I system and several SRs implicated in breast cancer...
  19. ncbi Orchestration of multiple arrays of signal cross-talk and combinatorial interactions for maturation and cell death: another vision of t(15;17) preleukemic blast and APL-cell maturation
    G Benoit
    INSERM U-496, , avenue Claude-Vellefaux, 75010 Paris, France
    Oncogene 20:7161-77. 2001
    ....
  20. ncbi P2 receptor web: complexity and fine-tuning
    Cinzia Volonte
    Santa Lucia Foundation CNR, Via del Fosso di Fiorano 64, 00143 Roma, Italy
    Pharmacol Ther 112:264-80. 2006
    ..In the present analysis, we stimulate a scientific query about what contributes to such a vast P2 receptor sophistication...
  21. ncbi The promise of retinoids to fight against cancer
    L Altucci
    Dipartimento di Patologia Generale e Oncologia, Seconda Universita degli Studi di Napoli, Italy
    Nat Rev Cancer 1:181-93. 2001
    ..Recent elucidation of the pathways that are activated by retinoids will help us to exploit the beneficial aspects of this powerful class of compounds for cancer therapy and prevention...
  22. pmc Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression
    Tiangang Li
    Department of Biochemistry and Molecular Pathology, Northeastern Ohio University College of Medicine, Rootstown, 44272, USA
    Drug Metab Dispos 34:756-64. 2006
    ..PXR concomitantly inhibits SHP gene transcription and maximizes the PXR induction of the CYP3A4 gene in human livers. Drugs targeted to PXR may be developed for treating cholestatic liver diseases induced by bile acids and drugs...
  23. ncbi Acquired resistance to oestrogen deprivation: role for growth factor signalling kinases/oestrogen receptor cross-talk revealed in new MCF-7X model
    Cindy M Staka
    Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, UK
    Endocr Relat Cancer 12:S85-97. 2005
    ..While inhibiting each pathway has potential to treat this state, combined therapy targeting all regulators of ER phosphorylation may be required to block subsequent emergence of resistance...
  24. pmc Mechanisms of cross-talk between G-protein-coupled receptors resulting in enhanced release of intracellular Ca2+
    Tim D Werry
    Department of Cell Physiology and Pharmacology, Medical Sciences Building, University of Leicester, UK
    Biochem J 374:281-96. 2003
    ..This review seeks to explore a range of possible mechanisms to convey their potential diversity and to provide a basis for further experimental investigation...
  25. ncbi Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer
    J M Gee
    Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Redwood Building, Cardiff University, Cardiff, UK
    Endocr Relat Cancer 12:S99-S111. 2005
    ..IGF-1R inhibitors may also prove valuable in ER- patients, since considerable IGF-1R signalling activity was apparent within approximately 50% of such tumours...
  26. ncbi Integrin alphavbeta3 mediates platelet-derived growth factor-BB-stimulated collagen gel contraction in cells expressing signaling deficient integrin alpha2beta1
    Gunilla Grundström
    Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, SE 751 23 Uppsala, Sweden
    Exp Cell Res 291:463-73. 2003
    ..Our results show that PDGF-BB stimulation of fibroblast-collagen interactions is mediated by the alphavbeta3 integrin when beta1 integrin function is impaired...
  27. ncbi Bidirectional signaling between the estrogen receptor and the epidermal growth factor receptor
    Ellis R Levin
    Division of Endocrinology, Long Beach Veterans Affairs Medical Center, Long Beach, California 90822, USA
    Mol Endocrinol 17:309-17. 2003
    ..Overall, the bidirectional cross-talk between EGFR and cellular pools of ER contributes to reproductive organ physiology and pathophysiology...
  28. pmc A computational model on the modulation of mitogen-activated protein kinase (MAPK) and Akt pathways in heregulin-induced ErbB signalling
    Mariko Hatakeyama
    RIKEN Genomic Sciences Center, 1 7 22 Suehirocho, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Biochem J 373:451-63. 2003
    ....
  29. pmc p38gamma mitogen-activated protein kinase integrates signaling crosstalk between Ras and estrogen receptor to increase breast cancer invasion
    Xiaomei Qi
    Department of Radiation Oncology, Loyola University Chicago, Maywood, IL, USA
    Cancer Res 66:7540-7. 2006
    ..Selective targeting of p38gamma-dependent invasion pathways may be a novel strategy to control breast cancer progression...
  30. ncbi Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway
    Bysani Chandrasekar
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 278:4675-86. 2003
    ..Thus, in addition to attracting and activating neutrophils, the ELR(+) CXC chemokines amplify the inflammatory cascade, stimulating local production of cytokines that have negative inotropic and proapoptotic effects...
  31. pmc Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling
    Christina D Keller
    Institute of Pharmacy, Pharmacology and Toxicology, Freie Universitat Berlin, Konigin Luise Str 2 4, D 14195 Berlin, Germany
    Am J Pathol 170:281-92. 2007
    ..Finally, we determined that downstream of S1P3 signaling Smad3 activation is essential for myofibroblast differentiation in response to FTY720. Thus, FTY720 may have adverse fibrotic effects related to its activity on S1P3 signaling...
  32. ncbi Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways
    Carla R O Carvalho
    Departamento de Clinica Medica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, 13081 970 Campinas, Brazil
    Endocrinology 144:638-47. 2003
    ..These results indicate a new signal transduction pathway for LH and show that there is positive cross-talk between the insulin and LH signaling pathways at the level of phosphoinositol 3-kinase/AKT pathway in this tissue...
  33. ncbi Signaling from MARK to tau: regulation, cytoskeletal crosstalk, and pathological phosphorylation
    T Timm
    Max Planck Unit for Structural Molecular Biology, Hamburg, Germany
    Neurodegener Dis 3:207-17. 2006
    ..Thus, MARK and its regulators MARKK and PAK5 appear to mediate the crosstalk between the actin and microtubule cytoskeleton in an antagonistic fashion...
  34. ncbi Transactivation of gp130 in myeloma cells
    Jena D French
    Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 170:3717-23. 2003
    ..Finally, transactivation of gp130 may be a common theme in myeloma cells, perhaps providing a mechanism for enhanced or qualitatively distinct cellular responses to specific stimuli...
  35. ncbi KN-62 enhances Chlamydia pneumoniae-induced p44/p42 mitogen-activated protein kinase activation in murine fibroblasts and attenuates in vitro infection
    Iana Haralambieva
    Department of Microbiology, Preclinical University Center, Medical University, Zdrave 2 Street, 1431, Sofia, Bulgaria
    FEMS Microbiol Lett 215:149-55. 2002
    ....
  36. ncbi Prolactin-signal transduction in neonatal rat pancreatic islets and interaction with the insulin-signaling pathway
    M E C Amaral
    Departamento de Fisiologia e Biofisica, Faculdade de Ciencias Medicas, Universidade Edtadual de Campinas UNICAMP, Campinas 13083 970, Sao Paulo, Brazil
    Horm Metab Res 35:282-9. 2003
    ..PRL also induced JAK2, SHC, ERK1 and ERK2 phosphorylation in neonatal islets, demonstrating that PRL can activate MAPK. These data indicate that PRL can stimulate the IRSs/PI 3-kinase and SHC/ERK pathways in islets from neonatal rats...
  37. ncbi Interaction and functional cooperation between the serine/threonine kinase bone morphogenetic protein type II receptor with the tyrosine kinase stem cell factor receptor
    Sylke Hassel
    Ludwig Institute for Cancer Research, Biomedical Centre, Uppsala, Sweden
    J Cell Physiol 206:457-67. 2006
    ..Our data suggest that the complex formation between c-kit and BMPR-II leads to phosphorylation of BMPR-II at Ser757, which modulates BMPR-II-dependent signaling...
  38. ncbi Identification of phospholipase C-gamma1 as a mitogen-activated protein kinase substrate
    Colin T Buckley
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131, USA
    J Biol Chem 279:41807-14. 2004
    ..These studies have uncovered a previously unidentified mechanism for the integration of PLC-gamma1- and ERK2-dependent signaling...
  39. ncbi Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells
    Ami Kuribayashi
    Molecular Diagnosis and Therapeutics, Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Endocrinology 145:4976-84. 2004
    ..The elucidation of such a unique mechanism involving cross-talk between EGFR and heterologous receptors may shed additional light on the clinical use of EGFR-TK inhibitors in antitumor therapies...
  40. ncbi The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary alphaT3 cells by protein kinase Calpha-mediated negative regulation of Akt
    Annabel Rose
    Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
    J Biol Chem 279:52500-16. 2004
    ..Our results demonstrate for the first time that several interactions take place between IGF-1 and LHRH receptors in gonadotrope cells...
  41. ncbi Cross talk between MyD88 and focal adhesion kinase pathways
    Mirjam B Zeisel
    Institut National de la Santé et de la Recherche Médicale 392, Faculte de Pharmacie, Illkirch, France
    J Immunol 174:7393-7. 2005
    ..Moreover, MyD88-dependent, LPS-induced IL-6 secretion by human and murine fibroblasts required the presence of FAK, confirming that MyD88 and FAK pathways are interlinked...
  42. ncbi B cell receptor (BCR) cross-talk: CD40 engagement creates an alternate pathway for BCR signaling that activates I kappa B kinase/I kappa B alpha/NF-kappa B without the need for PI3K and phospholipase C gamma
    Takuya Mizuno
    Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 174:6062-70. 2005
    ..The alternate BCR signaling pathway bypasses multiple signalosome elements and terminates in IKKbeta activation...
  43. ncbi Cross-talk between the estrogen receptor-, protein kinase A-, and mitogen-activated protein kinase-mediated signaling pathways in the regulation of lactotroph proliferation in primary culture
    Koji Yamakawa
    Department of Physiology, University of Yamanashi Interdisciplinary Graduate School of Medicine and Engineering, Tamaho, Nakakoma, Yamanashi 409 3898, Japan
    J Steroid Biochem Mol Biol 88:123-30. 2004
    ....
  44. ncbi Regulation of Na+ transport by aldosterone: signaling convergence and cross talk between the PI3-K and MAPK1/2 cascades
    Qiusheng Tong
    Dept of Chemistry and Biochemistry, Texas State Univ, 601 University Dr, CHEM 216, San Marcos, TX, USA
    Am J Physiol Renal Physiol 286:F1232-8. 2004
    ....
  45. ncbi Interactions between the aryl hydrocarbon receptor and P-TEFb. Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at cyp1a1 promoter
    Yanan Tian
    Department of Veterinary Physiology and Pharmacology, MS 4466, Texas A and M University, College Station, Texas 77843, USA
    J Biol Chem 278:44041-8. 2003
    ..Finally, we show that ligand-activated AhR associated with P-TEFb through the C terminus of cyclin T1, suggesting that AhR recruit the P-TEFb to the cyp1a1 promoter whereupon its kinase subunit phosphorylates the RNA PII CTD...
  46. ncbi Agonist-specific transactivation of phosphoinositide 3-kinase signaling pathway mediated by the dopamine D2 receptor
    Venugopalan D Nair
    Department of Neurology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    J Biol Chem 278:47053-61. 2003
    ..These results support the hypothesis that specific dopamine agonists stabilize distinct conformations of the D2 receptor that differ in their coupling to G-proteins and to a cytoprotective c-Src/EGFR-mediated PI-3 kinase/Akt pathway...
  47. ncbi Ganglioside GM3 blocks the activation of epidermal growth factor receptor induced by integrin at specific tyrosine sites
    Xiao Qi Wang
    Departments of Pediatrics and Dermatology, Children s Memorial Institute for Education and Research, Northwestern University Medical School, Chicago, Illinois 60614, USA
    J Biol Chem 278:48770-8. 2003
    ....
  48. ncbi Angiotensin II regulates phosphoinositide 3 kinase/Akt cascade via a negative crosstalk between AT1 and AT2 receptors in skin fibroblasts of human hypertrophic scars
    Hong Wei Liu
    Department of Plastic Surgery, Guangzhou Liuhuaqiao Hospital, Liuhua road 111, Guangzhou, Guangdong Province 510010, PR China
    Life Sci 79:475-83. 2006
    ..These findings contribute to understanding the molecular mechanism of human hypertrophic scar formation...
  49. ncbi Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes
    Tadimeti S Rao
    Merck Research Laboratories, 3535 General Atomics Court, Building 1, San Diego, CA 92121, USA
    Brain Res 990:182-94. 2003
    ....
  50. ncbi Cross-talk between endocrine-disrupting chemicals and cytokine signaling through estrogen receptors
    Yuichi Sekine
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    Biochem Biophys Res Commun 315:692-8. 2004
    ..This finding strongly suggests that EDCs may play an important role in the endocrine functions by mimicking cytokine activity by stimulating STAT3 actions through ERs...
  51. ncbi Akt mediates insulin-stimulated phosphorylation of Ndrg2: evidence for cross-talk with protein kinase C theta
    James G Burchfield
    Cell Signalling Group, Diabetes and Obesity Program, Garvan Institute of Medical Research, Sydney, New South Wales, Australia
    J Biol Chem 279:18623-32. 2004
    ..Our data identify Ndrg2 as a novel insulin-dependent phosphoprotein and suggest that PKC may inhibit insulin action in part by reducing its phosphorylation by Akt...
  52. ncbi Another role for the celebrity: Akt and insulin resistance
    Rong Tian
    Circ Res 96:139-40. 2005
  53. ncbi Altered growth response to prostaglandin E2 and its receptor signaling in mesangial cells from stroke-prone spontaneously hypertensive rats
    T Suganami
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan
    J Hypertens 19:1095-103. 2001
    ..The altered EP4 signaling may play a critical role in the exaggerated mesangial growth in SHRSPs...
  54. ncbi Crosstalk between androgen receptor and epidermal growth factor receptor-signalling pathways: a molecular switch for epithelial cell differentiation
    Laurent Leotoing
    Génétique des Eucaryotes et Endocrinologie Moléculaire, UMR 6547 CNRS, Equipe Physiologie Comparée et Endocrinologie Moléculaire, Universite Blaise Pascal, Campus Universitaire des Cezeaux, Aubiere Cedex, France
    J Mol Endocrinol 39:151-62. 2007
    ..Overall, our data demonstrate the existence of a balance between AR and mitogen-activated protein kinase activities that favours either the maintenance of differentiated conditions or the enhancement of cell proliferation capacities...
  55. ncbi Cross talk of the interferon-alpha/beta signalling complex with gp130 for effective interleukin-6 signalling
    Y Mitani
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan
    Genes Cells 6:631-40. 2001
    ..Our results also suggest the assembly of cytokine receptor subunits, which may represent a 'receptosome'-like structure, allowing the unique signalling cross talks to occur...
  56. pmc Oxytocin stimulates migration and invasion in human endothelial cells
    M G Cattaneo
    Department of Pharmacology, University of Milano, Via Vanvitelli 32, Milano, Italy
    Br J Pharmacol 153:728-36. 2008
    ..Among these, human umbilical vein endothelial cells (HUVECs) respond to oxytocin with an increased proliferation, suggesting a possible role for the hormone in the regulation of angiogenesis...
  57. ncbi The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptors
    Anne M Martin
    Institute of Physiological Chemistry and Pathobiochemistry, Molecular Neurodegeneration and Institute of Physiology, Johannes Gutenberg University Mainz, D 55099 Mainz, Germany
    J Biol Chem 283:12004-13. 2008
    ..These results provide new insights into the mechanism of a tPA-induced, LRP1-mediated gating mechanism for NMDA receptors...
  58. pmc Insulin-induced epidermal growth factor activation in vascular smooth muscle cells is ADAM-dependent
    Elisa Roztocil
    Vascular Biology and Therapeutics Program, Methodist DeBakey Heart and Vascular Center, Department of Cardiovascular Surgery, The Methodist Hospital, Houston, TX 77030, USA
    Surgery 144:245-51. 2008
    ..EGFR is transactivated by both G-protein-coupled receptors and receptor-linked tyrosine kinases and is key to many of their responses...
  59. pmc Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect
    Freddy Jeanneteau
    Molecular Neurobiology Program, Department of Cell Biology, Physiology, Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 105:4862-7. 2008
    ..The ability of GCs to promote Trk receptor activity represents a molecular mechanism that integrates the actions of GCs and neurotrophins...
  60. ncbi Cross-talk between alpha(4)beta(1)/alpha(5)beta(1) and c-Kit results in opposing effect on growth and survival of hematopoietic cells via the activation of focal adhesion kinase, mitogen-activated protein kinase, and Akt signaling pathways
    R Kapur
    The Section of Pediatric Hematology/Oncology, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indianapolis, Indiana 46202, USA
    Blood 97:1975-81. 2001
    ..Blood. 2001;97:1975-1981)..
  61. ncbi Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility
    J P Hobson
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007, USA
    Science 291:1800-3. 2001
    ..Our results reveal a role for receptor cross-communication in which activation of a GPCR by a receptor tyrosine kinase is critical for cell motility...
  62. pmc Inhibition of caspase 3 abrogates lipopolysaccharide-induced nitric oxide production by preventing activation of NF-kappaB and c-Jun NH2-terminal kinase/stress-activated protein kinase in RAW 264.7 murine macrophage cells
    D Chakravortty
    Department of Microbiology and Immunology and Division of Bacterial Toxin, Research Center for Infectious Disease, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan
    Infect Immun 69:1315-21. 2001
    ..The caspase family, especially caspase 3, is likely to play an important role in the signal transduction for iNOS-mediated NO production in LPS-stimulated mouse macrophages...
  63. ncbi A role for endogenous TGFalpha and associated signaling pathways in the differentiation of lens fiber cells
    F Chen
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan
    J Cell Physiol 186:288-97. 2001
    ..This could also mean that additional receptors for TGFalpha not inhibited by PD153035 are responsible for promoting differentiation in chick lens cells...
  64. ncbi Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes
    L M Luttrell
    Howard Hughes Medical Institute and Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Science 283:655-61. 1999
    ....
  65. pmc Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor
    C P Bagowski
    Department of Molecular Biology, Max Planck Institute for Biochemistry, Am Klopferspitz 18a, 82152 Martinsried, Germany
    EMBO J 18:5567-76. 1999
    ..Our results establish a novel crosstalk mechanism which allows signal integration and definition in cells with many different RTKs...
  66. pmc Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis
    Ganapati H Mahabeleshwar
    Department of Molecular Cardiology, The Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Circ Res 101:570-80. 2007
    ....
  67. ncbi Evidence for cross talk between PPARalpha and p38 MAP kinase
    Ruth A Roberts
    Syngenta CTL, Alderley Park, Macclesfield, SK10 4TJ, United Kingdom
    Toxicol Sci 68:270-4. 2002
  68. ncbi Insulinlike growth factor-I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk
    Ya Wei Qiang
    Laboratory of Cellular and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4255, USA
    Blood 99:4138-46. 2002
    ..These results define important elements in IGF-I regulation of myeloma cell growth and provide biological correlates critical to an understanding of growth-factor modulation of proliferation and apoptosis...
  69. ncbi Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors
    Nicholas J Brandon
    Medical Research Council, Laboratory of Molecular Cell Biology and Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 22:6353-61. 2002
    ..Therefore, RACK-1 will enhance functional cross talk between GABA(A) receptors and G-protein-coupled receptors and therefore may have profound effects on neuronal excitability...
  70. ncbi Cross-talk between bone morphogenic proteins and estrogen receptor signaling
    Tetsuya Yamamoto
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita Ku Kita 12 Nishi 6, Sapporo 060 0812, Japan
    Endocrinology 143:2635-42. 2002
    ..We provide evidence that the inhibitory action of ER on Smad activity was due to direct physical interactions between Smads and ER, which represents a novel mechanism for the cross-talk between BMP and ER signaling pathways...
  71. ncbi Estrogen receptor alpha (ERalpha) and insulin-like growth factor I receptor (IGF-IR) cross-talk in the gonadotropic alphaT3-1 cell line
    Frank Eertmans
    Department of Endocrinology, 6K12IE, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium
    J Cell Physiol 212:583-90. 2007
    ..In conclusion, our data indicate IGF-IR and ER interactions in the alphaT3-1 cell line, an in vitro model for the pituitary gonadotrophs, hereby suggesting a role of IGF-I in the regulation of gonadotropin synthesis and secretion...
  72. ncbi Src-mediated inter-receptor cross-talk between the Na+/K+-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases
    Michael Haas
    Department of Pharmacology, Medical College of Ohio, Toledo, Ohio 43614, USA
    J Biol Chem 277:18694-702. 2002
    ..Taken together, these new findings suggest that Src mediates the inter-receptor cross-talk between Na(+)/K(+)-ATPase and the EGFR to transduce the signals from ouabain to the Ras/MAPK cascade...
  73. pmc Cross talk between c-Met and epidermal growth factor receptor during retinal pigment epithelial wound healing
    Ke Ping Xu
    Kresge Eye Institute, Departments of Ophthalmology and of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Invest Ophthalmol Vis Sci 48:2242-8. 2007
    ..The authors sought to determine how hepatocyte growth factor (HGF) receptor c-Met and epidermal growth factor receptor (EGFR) cross talk in response to injury in human ARPE-19 cells...
  74. ncbi Unraveling the story of NGF-mediated sensitization of nociceptive sensory neurons: ON or OFF the Trks?
    Grant D Nicol
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Mol Interv 7:26-41. 2007
    ..Furthermore, controversy exists as to the downstream signaling pathways involved in NGF-induced peripheral sensitization...
  75. ncbi VEGF and VEGFR-2 (KDR) internalization is required for endothelial recovery during wound healing
    Susana Constantino Rosa Santos
    Angiogenesis Laboratory, Centro de Investigação em Patobiologia Molecular, Instituto Portugues de Oncologia Francisco Gentil CROL, SA, Lisboa, Portugal
    Exp Cell Res 313:1561-74. 2007
    ..Our data reveal a previously unrecognized mechanism induced by VEGF on EC, which regulates EC recovery following wounding, and as such indicate novel targets for therapeutic intervention...
  76. ncbi Sex hormone regulation of systemic endothelial and renal microvascular reactivity in type-2 diabetes: studies in gonadectomized and sham-operated Zucker diabetic rats
    A A Ajayi
    Center for Cardiovascular Diseases, Texas Southern University, Houston, Texas 77004, USA
    Eur J Clin Invest 34:349-57. 2004
    ..The plasma concentrations of both thromboxanes and endothelins are elevated in diabetes, and the receptor cross-talk between TXA(2) and ET-1 receptors may be enhanced in type-2 diabetic Zucker rats...
  77. pmc Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S,3R-ACPD in neonatal rat cerebral cortex
    R A Challiss
    Department of Cell Physiology and Pharmacology, University of Leicester
    Br J Pharmacol 112:231-9. 1994
    ..We believe the former effect could be fundamental in glutamate receptor 'cross-talk', whereas the latter may reflect a Ca2+-dependent neurotoxic effect of NMDA on the neonatal cerebral cortex slices...
  78. ncbi [Impacts and impact mechanisms of "dioxins" in humans and animals]
    H Nau
    Institut für Lebensmitteltoxikologie und Chemische Analytik, Lebensmitteltoxikologie, Stiftung Tierarztliche Hochschule Hannover
    Dtsch Tierarztl Wochenschr 113:292-7. 2006
    ..This shows that the exposure of the human to dioxins should be minimized wherever possible...
  79. pmc Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling
    Katsuaki Ieguchi
    Department of Dermatology, University of California Davis School of Medicine, Sacramento, California 95817, USA
    J Biol Chem 285:31388-98. 2010
    ..These results suggest that direct NRG1-integrin interaction mediates integrin-ErbB cross-talk and that α6β4 plays a major role in NRG-ErbB signaling in these cancer cells...
  80. ncbi Endothelin-like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague Dawley rats
    A A Ajayi
    Center for Cardiovascular Diseases, COPHS, Texas Southern University, Houston 77004, USA
    Methods Find Exp Clin Pharmacol 25:817-22. 2003
    ..These findings suggest a strong possibility of post-receptor cross-talk between alpha2-adrenoceptors and endothelin, as well as a direct effect of alpha2-adrenoceptors on renal NO production...
  81. ncbi Genistein effects on growth and cell cycle of Candida albicans
    A Yazdanyar
    Des Moines University Osteopathic Medical Center, 3200 Grand Avenue, Des Moines, IA 50312, USA
    J Biomed Sci 8:153-9. 2001
    ..This study raises the possibility of receptor cross-talk between estrogen and isoflavinoid compounds, and antiestrogens which may affect the same signaling system, though separate targets for each compound were not ruled out...
  82. pmc Cross-talk between G protein-coupled and epidermal growth factor receptors regulates gonadotropin-mediated steroidogenesis in Leydig cells
    Kristen Evaul
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8857, USA
    J Biol Chem 283:27525-33. 2008
    ..These results suggest that GPCR-EGF receptor cross-talk is a conserved regulator of gonadotropin-induced steroidogenesis in the gonads, although the mechanisms of EGF receptor trans-activation may vary...
  83. pmc Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver
    Kouichi Nakamura
    Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 282:9768-76. 2007
    ..These results are consistent with the conclusion that PCN-activated PXR represses FoxA2-mediated transcription of Ctp1a and Hmgcs2 genes in fasting liver...
  84. pmc Human nuclear pregnane X receptor cross-talk with CREB to repress cAMP activation of the glucose-6-phosphatase gene
    Susumu Kodama
    Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Biochem J 407:373-81. 2007
    ..Thus drug activation of PXR can repress the transcriptional activity of CREB, down-regulating gluconeogenesis...
  85. ncbi Receptor cross-talk can optimize assays for autoantibodies to the thyrotropin receptor: effect of phenylisopropyladenosine on adenosine 3',5'-monophosphate and inositol phosphate levels in rat FRTL-5 thyroid cells
    A Hidaka
    Section on Cell Regulation, Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 20892
    J Clin Endocrinol Metab 77:1164-9. 1993
    ..Although NaCl-free HBSS improved TSH- or Graves' IgG-induced IP and cAMP production in cells with recombinant TSHR; the modulatory action of phenylisopropyladenosine was lost...
  86. ncbi Protein kinase C activation enhances morphine-induced rapid desensitization of mu-opioid receptors in mature rat locus ceruleus neurons
    Christopher P Bailey
    Department of Pharmacology, University of Bristol, University Walk, Bristol, United Kingdom
    Mol Pharmacol 66:1592-8. 2004
    ....
  87. ncbi Cholinergic and adrenergic modulation of the Ca2+ response to endothelin-1 in human ciliary muscle cells
    G Prasanna
    Department of Pharmacology, University of North Texas Health Science Center, Fort Worth 76107, USA
    Invest Ophthalmol Vis Sci 41:1142-8. 2000
    ..To determine the cholinergic (carbachol, CCH) and adrenergic (norepinephrine, NE) modulation of Ca2+ response to endothelin-1 in human ciliary smooth muscle (HCSM) cells...
  88. ncbi Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk
    Diane M Klotz
    Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 277:8531-7. 2002
    ....
  89. ncbi The Lipoxin A4 receptor is coupled to SHP-2 activation: implications for regulation of receptor tyrosine kinases
    Derick Mitchell
    School of Medicine and Medical Science, Diabetes Research Centre, UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    J Biol Chem 282:15606-18. 2007
    ..These data further elaborate on the potential mechanisms underlying the anti-inflammatory, proresolution, and anti-fibrotic bioactions of lipoxins...
  90. ncbi Angiotensin II and epidermal growth factor receptor cross-talk mediated by a disintegrin and metalloprotease accelerates tumor cell proliferation of hepatocellular carcinoma cell lines
    Hidenori Itabashi
    Departments of Pathology and Surgery, School of Medicine, Iwate Medical University, Morioka, Japan
    Hepatol Res 38:601-13. 2008
    ..Conclusion: These results suggest that AngII-EGFR cross-talk signaling mediated by ADAMs is involved in the proliferation and invasion activities of several HCC cell lines...
  91. ncbi Somatostatin and dopamine receptor interaction in prostate and lung cancer cell lines
    M Arvigo
    Department of Endocrinological and Medical Sciences and Center of Excellence for Biomedical Research, Universita degli Studi di Genova, 16132 Genova, Italy
    J Endocrinol 207:309-17. 2010
    ..71%), suggesting a key role for D₂R in receptor cross talk and in controlling cell growth...
  92. ncbi 2,3,7,8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells
    J T Sanderson
    Research Institute for Toxicology, Utrecht University, P O Box 80176, 3508 TD Utrecht, The Netherlands
    Toxicol Sci 61:40-8. 2001
    ....
  93. ncbi Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors
    Jason N Peart
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 285:H81-9. 2003
    ..Furthermore, these data suggest that there are converging pathways and/or receptor cross-talk between A1AR- and DOR-mediated cardioprotection...
  94. ncbi Synchronous onset of NGF and TrkA survival dependence in developing dorsal root ganglia
    F A White
    Center for the Study of Nervous System Injury, Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 16:4662-72. 1996
    ..We suggest that the discrepancy in cell loss between NT-3(-/-) and trkC(-/-) mutants is attributable to the ability of NT-3 to support DRG neurons via TrkA in the artificial situation where TrkC is absent...
  95. ncbi Angiotensin II type 1 receptor-EGF receptor cross-talk regulates ureteric bud branching morphogenesis
    Ihor V Yosypiv
    Department of Pediatrics, Tulane University Health Sciences Center, SL 37, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    J Am Soc Nephrol 17:1005-14. 2006
    ..This process depends on tyrosine phosphorylation of the EGFR. Cooperation of AT(1)R and EGFR signaling therefore is important in the development of the renal collecting system...
  96. ncbi P2Y12 receptor signalling towards PKB proceeds through IGF-I receptor cross-talk and requires activation of Src, Pyk2 and Rap1
    Kristof Van Kolen
    Laboratory of Cellular Biochemistry, Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Wilrijk Antwerpen, Belgium
    Cell Signal 18:1169-81. 2006
    ....
  97. ncbi Activating and inhibitory Ly49 receptors modulate NK cell chemotaxis to CXC chemokine ligand (CXCL) 10 and CXCL12
    Marit Inngjerdingen
    Department of Arthritis and Immunology, Veterans Affairs Medical Center, Northern California Institute for Research and Education, and University of California, San Francisco, CA 94121, USA
    J Immunol 171:2889-95. 2003
    ..Collectively, these data suggest that Ly49 receptors can influence NK cell chemotaxis within sites of inflammation or tumor growth upon interaction with target cells...
  98. ncbi Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice
    Simrat P S Saini
    Center for Pharmacogenetics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Hepatology 41:497-505. 2005
    ..PXR is a potential therapeutic target for clinical treatment of jaundice. (HEPATOLOGY 2005;41:497-505.)...
  99. ncbi Endothelin receptor selectivity: evidence from in vitro and pre-clinical models of scleroderma
    X Shiwen
    University College London, London, UK
    Eur J Clin Invest 39:19-26. 2009
    ..Here, we discuss the available pre-clinical evidence for the role of the ET system in tissue repair, scarring and fibrosis, using the connective tissue diseases SSc and model systems of fibrogenesis...
  100. ncbi Heparin-binding EGF-like growth factor expression increases selectively in bladder smooth muscle in response to lower urinary tract obstruction
    J G Borer
    Department of Urology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Lab Invest 79:1335-45. 1999
    ..These data support a physiologic role for HB-EGF as a mediator of hypertrophic bladder tissue growth...
  101. ncbi Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends
    Peter Hoffmann
    Safety and Technical Sciences, F Hoffmann La Roche Ltd, 4070 Basel, Switzerland
    J Pharmacol Toxicol Methods 53:87-105. 2006
    ..Little is known about channel/receptor cross talk, although considerable evidence exists that cardiac G protein-coupled receptors can modulate hERG channel ..

Research Grants63

  1. PERINATAL METABOLIC AND HORMONAL EFFECTS
    Sherin U Devaskar; Fiscal Year: 2010
    ..The results of our proposed investigations will fill vital gaps in our knowledge and provide the molecular and cellular basis for perinatal nutritional perturbations causing permanent changes in feeding behavior/energy expenditure. ..
  2. Cell Priming, Receptor Cross-talk and Acute Lung Injury
    Mark A Wilson; Fiscal Year: 2013
    ..In a broader sense, the studies will contribute to a greater understanding of the pathogenesis of a number of human diseases in which EC are involved in the inflammatory process. ..
  3. Mechanisms of Herceptin resistance
    Rita Nahta; Fiscal Year: 2013
    ..Understanding the mechanisms leading to acquired Herceptin resistance will ultimately lead to refined therapeutic strategies and improved survival rates for patients with breast cancer. ..
  4. Receptor Tyrosine Kinases: Biology and Cancer
    Jonathan A Cooper; Fiscal Year: 2010
    ..Such a conference is timely because of exciting recent developments in receptor cross talk, therapeutic advances, and deeper understanding of Receptor Tyrosine Kinases (RTKs) in the brain and ..
  5. Receptor Cross-Talk in Early Metastatic Dissemination
    MARY SHARON STACK; Fiscal Year: 2013
    ..The long-term goal of these studies is to cultivate a molecular level understanding of EOC metastasis, necessary for the development of EOC-specific therapies that effectively target metastatic disease. ..
  6. SPERM GLYCINE RECEPTORS AND ZONA-INITIATED EXOCYTOSIS
    Stanley Meizel; Fiscal Year: 2006
    ..abstract_text> ..
  7. CD3 e functions in T cells
    NICOLAI VAN OERS; Fiscal Year: 2009
    ..Novel therapeutic strategies for intervening in T cell functions could emanate from our studies. ..
  8. AUTONOMIC MUSCARINIC RECEPTOR SIGNALING MECHANISMS
    FRED EHLERT; Fiscal Year: 2000
    ..that is opposed by activation of the M2 muscarinic receptor; 6) to identify novel mechanisms of muscarinic receptor cross talk in smooth muscle; 7) to determine whether activation of M2 muscarinic receptors in smooth muscle prevents ..
  9. Coexpression of EGFRvlll/ErbB2 in Human Breast Cancer
    Careen Tang; Fiscal Year: 2005
    ..The results of the proposed studies may ultimately point to new directions of molecular therapies of breast cancer. ..
  10. Chemoreception and Signal Amplification
    MICHAEL MANSON; Fiscal Year: 2005
    ..The supramolecular architecture of the receptor patch and its associated proteins will be examined using electron tomography. ..
  11. MECHANISMS OF MUSCARINIC RECEPTOR CROSS-TALK IN BRAIN
    FRED EHLERT; Fiscal Year: 1993
    ..The results of these studies may reveal new cholinergic mechanisms in the brain which may be compromised in Alzheimer's disease and other mental disorders of cholinergic hypofunction...
  12. Signaling and Crosstalk by Airway Prostanoid Receptors
    DENNIS MCGRAW; Fiscal Year: 2006
    ..receptor are frequently modulated by another, experiments in Specific Aim 3 will test the hypothesis that receptor cross talk by TP and EP1 receptors is a mechanism of (-adrenergic receptor dysfunction in ASM...
  13. ASSEMBLY/REGULATION OF CD40 RECEPTOR COMPLEX IN B CELLS
    Randolph Noelle; Fiscal Year: 2001
    ..Studies are proposed which will evaluate if engagement of one TNFR family member can prohibit the recruitment of TRAFs by other family members; and what the functional consequences of receptor desensitization are to the B-cell. ..
  14. Using BRET to measure insulin resistance and receptor cross-talk
    CHRISTOPHER HUPFELD; Fiscal Year: 2007
    ..This proposal uses a novel technology, bioluminescence resonance energy transfer, to study insulin resistance in real time in live cultured cells. [unreadable] [unreadable]..
  15. ERBB KINASE ACTIVATION AND TRANSFORMATION
    Hsing Jien Kung; Fiscal Year: 2004
    ..The present proposal is based on the above three novel findings and intends to study: 1) the mechanisms involved in receptor cross talk between erbB2 and IL6 receptor and 2) the NED signal pathways mediated by erbB2 and Etk.
  16. CELL ADHESION IN TISSUE MORPHOGENESIS
    William Carter; Fiscal Year: 2001
    ..these results will define the molecular mechanism through which cell adhesion regulates gene expression and wound repair in epithelium. ..
  17. The International Symposium on Regulatory Peptides
    JUAN ROZENGURT; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  18. Ion Regulation of Kv Channel Gating and Permeation
    Carol Deutsch; Fiscal Year: 2007
    ..The second aim will test whether ions in the selectivity filter modulate the movement of voltage sensors. These studies will entail measurements of kinetics and voltage dependence of gating currents in HEK cells. ..
  19. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010
    ....
  20. Regulation of cyp1a1 by Ah Receptor and NFkB Interaction
    Yanan Tian; Fiscal Year: 2009
    ..The proposed studies will help us gain mechanistic understandings of the functions of AhR and NF-kB in normal physiology as well as pathogenesis induced by dioxin and related compounds. ..
  21. Molecular Genetics of Cadmium Toxicity
    Daniel W Nebert; Fiscal Year: 2010
    ....
  22. Adrenergic and Purinergic Regulation of Target Cells
    Paul A Insel; Fiscal Year: 2010
    ....
  23. Aging Research in Immunology: Satellite to 2006 European Congress of Immunology
    John Cambier; Fiscal Year: 2006
    ..This conference, the first of its kind, will enhance progress by promoting new collaborations exchange of new data and training of scientists who wish to enter this field of research. [unreadable] [unreadable] [unreadable]..
  24. Tumor Selective Apoptosis by TRAIL
    Roya Khosravi Far; Fiscal Year: 2010
    ..These agents could provide significant enhancements in the current therapeutic strategies in hematological malignancies and other tumors that show resistance to apoptosis-inducing therapeutics. ..
  25. Characterization of anergic human B cells
    John Cambier; Fiscal Year: 2007
    ..This work will allow us to identify anergic cells in humans and further our understanding of the conditions which lead to B cell anergy. [unreadable] [unreadable]..
  26. Interactive Mediators of Injury & Development
    Parviz Minoo; Fiscal Year: 2008
    ..1. ..
  27. Genomic-wide Kinase Sequencing of Pediatric Brain Tumors
    Thomas Roberts; Fiscal Year: 2008
    ..Since cancers of children are often "informative" in a larger context, it is likely that these medicines will find use for more frequent adult cancers. ..
  28. Inhibition of Pancreatic Cancer by New PPARgamma Agonis*
    Stephen Safe; Fiscal Year: 2008
    ..PPAR? -active C-substituted DIMs that inhibit pancreatic cancer cell growth in vitro and in vivo, and these will serve as lead compounds for development of new drugs for clinical treatment of this devastating disease ..
  29. The Role of 4-1BB in T Cell and APC Interactions
    Michael Croft; Fiscal Year: 2010
    ..abstract_text> ..
  30. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2009
    ..abstract_text> ..
  31. Cell Signaling, PXR Phosphorylation & Drug Disposition
    Jeffrey Staudinger; Fiscal Year: 2009
    ..These studies will provide additional insight into the regulation of drug disposition and drug-drug interaction. ..
  32. Regulation of T cell Functions by the Breast Cancer Microenvironment
    Matthew F Krummel; Fiscal Year: 2010
    ..Finally, and not insignificantly, they will shed considerable light upon a previously inaccessible cell population which may protect the tumor from the immune response and thus permit tumor growth and metastasis. ..
  33. Regulation of DC Activity by Memory and Effector CD8+ T Cells
    Pawel Kalinski; Fiscal Year: 2010
    ..abstract_text> ..
  34. MECHANISMS OF CANNABINOIDS ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2001
    ..The results will define an important role for the cannabinoid receptors in the vomiting circuits and may implicate an antiemetic role for the endogenous cannabinoids. ..
  35. Olympus FV1000 Laser Scanning Confocal Microscope
    William Bement; Fiscal Year: 2007
    ..This information, in turn, will help guide future investigations of a number of normal and pathological human processes such as wound repair, nerve regeneration, cancer, and birth defects. [unreadable] [unreadable] [unreadable]..
  36. MOLECULAR BASIS OF SNELL DWARF AND LITTLE LONGEVITY
    John Papaconstantinou; Fiscal Year: 2003
    ..Achieving these aims will identify pathways involving longevity and lay down foundations for understanding the mechanism by which these pathways act. ..
  37. COACTIVATION SIGNALS REGULATE THYMOCYTE DEVELOPMENT
    David McKean; Fiscal Year: 2005
    ..These analyses will determine how signals integrated from different co-inducer receptors stimulate cross-talk between signaling pathways that affects the outcome of thymocyte selection. ..
  38. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
    ..abstract_text> ..
  39. A ROLE FOR NOGGIN AND BMP2/4 IN HAIR GROWTH CONTROL
    Vladimir Botchkarev; Fiscal Year: 2003
    ..abstract_text> ..
  40. BIOLOGY OF HUMAN INTRAEPITHELIAL LYMPHOCYTES
    Ellen Ebert; Fiscal Year: 2002
    ..These studies will determine the mechanism of IEL chemotaxis toward secreted products of ECs, why IL-15 is more potent than IL-2 in inducing LAK activity by IELs, and how IL-10 and IL-12 augment this activity. ..
  41. NEURONAL ACTIVITY AND INTRACELLULAR SIGNALING
    PHILIP STORK; Fiscal Year: 2003
    ..The applicant believes that the experiments outlined in this proposal may ultimately impact more general research on synaptic plasticity, long-term potentiation (LTP) and neuronal survival. ..
  42. Receptor 'transactivation' in insulin signaling.
    Louis Luttrell; Fiscal Year: 2004
    ..Understanding these mechanisms may lead to pharmacologic approaches to dissociate the potentially harmful proliferative effects of insulin family receptors from their anti-apoptotic and metabolic effects. ..
  43. MECHANISMS OF ANESTHETIC ACTION ON SMOOTH MUSCLE
    JUDY SU; Fiscal Year: 2004
    ..Further the understanding of signal pathways of CaMKII and PKC in smooth muscle will advance understanding mechanisms of agonist-activated force maintenance in smooth muscle, as well as cell motility and migration in non-muscle cells. ..
  44. Research Echocardiography System
    Thomas Force; Fiscal Year: 2004
    ....
  45. MECHANISMS OF PROSTAGLANDIN INDUCED INTESTINAL REPAIR
    Anthony Blikslager; Fiscal Year: 2002
    ..These experiments will provide insight into the signaling pathways and mechanisms by which prostaglandins trigger repair of acutely-injured intestinal epithelium. ..
  46. Beta-Adrenergic Receptors of S49 Lymphoma Cells
    Paul Insel; Fiscal Year: 2005
    ..Moreover, the results should prove applicable to the many other hormone and neurotransmitter receptors that link to G proteins. ..
  47. FUNCTION OF NOGGIN IN HAIR FOLLICLE GROWTH AND DISEASE
    Vladimir Botchkarev; Fiscal Year: 2006
    ....
  48. IMMUNE RESPONSE MODIFYING VACCINES FOR ASTHMA
    Shoshana Levy; Fiscal Year: 2003
    ..In addition, these studies will expand our understanding of the role of T cells that protect against these common disorders. ..
  49. Proinflammatory Signaling in the Pulmonary Circulation
    Jahar Bhattacharya; Fiscal Year: 2002
    ..Both the site and the format of the conference have proved successful in earlier meetings. ..
  50. 2,3,7,8,--TCDD Effects on the Estrogenic Responses
    Stephen Safe; Fiscal Year: 2006
    ..The proposed Aims will address important mechanistic considerations on IDRE-independent inhibitory AhR-ERa crosstalk and pathways critical for inhibition of mammary tumor growth by SAhRMs. ..
  51. LYMPHOTOXIN AB AND LIGHT CYTOKINE SYSTEMS
    Carl Ware; Fiscal Year: 2002
    ..He intends to investigate the connection between LIGHT and lymphoid development, as well as viral pathogenesis, given that HVEM serves as a receptor for glycoprotein D of Herpes simplex virus type I. ..
  52. A NOVEL FAS APOPTOSIS INHIBITORY MOLECULE (FAIM)
    THOMAS ROTHSTEIN; Fiscal Year: 2003
    ..abstract_text> ..
  53. MOLECULAR MECHANISMS OF CHEMICAL ATHEROGENESIS
    Kenneth Ramos; Fiscal Year: 2005
    ..These studies will enable us to define the role of ARE/EpRE binding proteins in oxidant-induced atherogenesis and identify critical transacting factors involved in the atherogenic response to environmental injury. ..
  54. The small G protein Rap 1 in T cell activation/anergy
    PHILIP STORK; Fiscal Year: 2005
    ..In addition, we will test the hypothesis that CD28 co-stimulation achieves increased ERK activation, IL-2 production and proliferation by blocking Rap1 activation. ..
  55. SYNAPTIC PLASTICITY OF HYPOTHALAMIC NEURONS--ESTROGENS
    OLINE RONNEKLEIV; Fiscal Year: 2002
    ....
  56. Epithelial Barrier During Corneal Infection
    Fu Shin Yu; Fiscal Year: 2004
    ....
  57. ALKYL PCDFS--INHIBITION OF MAMMARY CANCER
    Stephen Safe; Fiscal Year: 2001
    ..Thus the proposed studies will define a new mechanism-based class of antiestrogens that can be used alone or in combination with tamoxifen for treatment of breast and endometrial cancer. ..
  58. ECM Regulation by Estrogen in ARMD
    Sharon Elliot; Fiscal Year: 2006
    ..Conversely, we expect that estrogen's antioxidant action on the cell membrane will diminish MPO-induced blebbing and that activation of estrogen receptors will modify matrix molecule dysregulation. ..
  59. Transcription Regulation by B-Cell Receptor Signaling
    Wasif Khan; Fiscal Year: 2004
    ..Identification of these important missing links may reveal new immunotherapeutic targets for intervention in B-cell deficiency diseases such as XLA. ..
  60. Interferon Regulation in Systemic Lupus
    Lionel B Ivashkiv; Fiscal Year: 2010
    ..These experiments will yield insight into the molecular pathogenesis of SLE and identify novel therapeutic approaches to manipulatecytokine activity in SLE at the level of signal transduction. ..