sperm motility

Summary

Summary: Movement characteristics of SPERMATOZOA in a fresh specimen. It is measured as the percentage of sperms that are moving, and as the percentage of sperms with productive flagellar motion such as rapid, linear, and forward progression.

Top Publications

  1. ncbi A sperm ion channel required for sperm motility and male fertility
    D Ren
    Howard Hughes Medical Institute, Children s Hospital, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 413:603-9. 2001
  2. ncbi Identification of the human testis protein phosphatase 1 interactome
    Margarida Fardilha
    Signal Transduction Laboratory, Centre for Cell Biology, Biology Department, University of Aveiro, 3810 193 Aveiro, Portugal
    Biochem Pharmacol 82:1403-15. 2011
  3. pmc Ca2+ signals generated by CatSper and Ca2+ stores regulate different behaviors in human sperm
    Wardah Alasmari
    From the Reproductive and Developmental Biology, Medical School, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 288:6248-58. 2013
  4. ncbi Protein phosphatase 1 complexes modulate sperm motility and present novel targets for male infertility
    Margarida Fardilha
    Signal Transduction Laboratory, Centre for Cell Biology, Health Sciences Department and Biology Department, University of Aveiro, Campus de Santiago, 3810 193 Aveiro, Portugal
    Mol Hum Reprod 17:466-77. 2011
  5. pmc Sperm competition and the evolution of sperm design in mammals
    Maximiliano Tourmente
    Reproductive Ecology and Biology Group, Museo Nacional de Ciencias Naturales CSIC, Jose Gutierrez Abascal 2, 28006 Madrid, Spain
    BMC Evol Biol 11:12. 2011
  6. ncbi Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel
    Polina V Lishko
    Department of Physiology, University of California, San Francisco, UCSF Mail Code 2140, Genentech Hall, Room N272F, 600 16 th Street, San Francisco, CA 94158, USA
    Cell 140:327-37. 2010
  7. ncbi Male fertility in natural populations of red deer is determined by sperm velocity and the proportion of normal spermatozoa
    Aurelio F Malo
    Reproductive Ecology and Biology Group, Museo Nacional de Ciencias Naturales CSIC, 28006 Madrid, Spain
    Biol Reprod 72:822-9. 2005
  8. pmc The control of male fertility by spermatozoan ion channels
    Polina V Lishko
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Physiol 74:453-75. 2012
  9. ncbi Characterization of the intracellular calcium store at the base of the sperm flagellum that regulates hyperactivated motility
    Han Chen Ho
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Biol Reprod 68:1590-6. 2003
  10. ncbi Oxidative stress & male infertility
    Kartikeya Makker
    Center for Reproductive Medicine, Glickman Urological and Kidney Institute and Obsterics Gynecology and Women s Health Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Indian J Med Res 129:357-67. 2009

Detail Information

Publications362 found, 100 shown here

  1. ncbi A sperm ion channel required for sperm motility and male fertility
    D Ren
    Howard Hughes Medical Institute, Children s Hospital, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 413:603-9. 2001
    ..have crucial roles in mammalian fertilization, but the molecules comprising the Ca2+-permeation pathway in sperm motility are poorly understood...
  2. ncbi Identification of the human testis protein phosphatase 1 interactome
    Margarida Fardilha
    Signal Transduction Laboratory, Centre for Cell Biology, Biology Department, University of Aveiro, 3810 193 Aveiro, Portugal
    Biochem Pharmacol 82:1403-15. 2011
    ..The importance of the testis/sperm-enriched variant, PP1γ2, in sperm motility and spermatogenesis has previously been shown...
  3. pmc Ca2+ signals generated by CatSper and Ca2+ stores regulate different behaviors in human sperm
    Wardah Alasmari
    From the Reproductive and Developmental Biology, Medical School, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, Scotland, United Kingdom
    J Biol Chem 288:6248-58. 2013
    Ca(2+)]i signaling regulates sperm motility, enabling switching between functionally different behaviors that the sperm must employ as it ascends the female tract and fertilizes the oocyte...
  4. ncbi Protein phosphatase 1 complexes modulate sperm motility and present novel targets for male infertility
    Margarida Fardilha
    Signal Transduction Laboratory, Centre for Cell Biology, Health Sciences Department and Biology Department, University of Aveiro, Campus de Santiago, 3810 193 Aveiro, Portugal
    Mol Hum Reprod 17:466-77. 2011
    ..Recent findings support our hypothesis that PP1γ2 is involved in the regulation of sperm motility. This review summarizes the known sperm-specific PP1-PIPs, involved in the acquisition of mammalian sperm ..
  5. pmc Sperm competition and the evolution of sperm design in mammals
    Maximiliano Tourmente
    Reproductive Ecology and Biology Group, Museo Nacional de Ciencias Naturales CSIC, Jose Gutierrez Abascal 2, 28006 Madrid, Spain
    BMC Evol Biol 11:12. 2011
    ..In addition, the debate has extended to which sperm components should increase in size: the midpiece to accommodate more mitochondria and produce more energy to fuel motility, or the principal piece to generate greater propulsion forces...
  6. ncbi Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel
    Polina V Lishko
    Department of Physiology, University of California, San Francisco, UCSF Mail Code 2140, Genentech Hall, Room N272F, 600 16 th Street, San Francisco, CA 94158, USA
    Cell 140:327-37. 2010
    ..The importance of Hv1 for sperm activation makes it an attractive target for controlling male fertility...
  7. ncbi Male fertility in natural populations of red deer is determined by sperm velocity and the proportion of normal spermatozoa
    Aurelio F Malo
    Reproductive Ecology and Biology Group, Museo Nacional de Ciencias Naturales CSIC, 28006 Madrid, Spain
    Biol Reprod 72:822-9. 2005
    ..Our analyses revealed strong associations between sperm production and sperm swimming velocity, sperm motility and proportion of morphologically normal spermatozoa, and sperm viability and acrosome integrity...
  8. pmc The control of male fertility by spermatozoan ion channels
    Polina V Lishko
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Annu Rev Physiol 74:453-75. 2012
    ..The uniqueness of sperm ion channels makes them ideal pharmaceutical targets for contraception. In this review we discuss how ion channels regulate sperm physiology...
  9. ncbi Characterization of the intracellular calcium store at the base of the sperm flagellum that regulates hyperactivated motility
    Han Chen Ho
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Biol Reprod 68:1590-6. 2003
    Hyperactivated sperm motility is usually characterized by high-amplitude flagellar bends and asymmetrical flagellar beating...
  10. ncbi Oxidative stress & male infertility
    Kartikeya Makker
    Center for Reproductive Medicine, Glickman Urological and Kidney Institute and Obsterics Gynecology and Women s Health Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Indian J Med Res 129:357-67. 2009
    ..It also highlights the mechanism of production and the pathophysiology of ROS in relation to the male reproductive system and enumerate the benefits of incorporating antioxidants in clinical and experimental settings...
  11. ncbi Resolving mechanisms of competitive fertilization success in Drosophila melanogaster
    Mollie K Manier
    Department of Biology, Syracuse University, Syracuse, NY 13244 1270, USA
    Science 328:354-7. 2010
    ..We find that competitive male fertilization success derives from a multivariate process involving ejaculate-female and ejaculate-ejaculate interactions, as well as complex sperm behavior in vivo...
  12. ncbi Clinical relevance of oxidative stress in male factor infertility: an update
    Ashok Agarwal
    Department of Obstetrics Gynecology, Cleveland Clinic, Cleveland, OH 44195, USA
    Am J Reprod Immunol 59:2-11. 2008
    ..The benefits of incorporating antioxidants in clinical and experimental settings have been enumerated. We also highlight the emerging concept of utilizing OS as a method of contraception and the potential problems associated with it...
  13. pmc The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization
    Kenneth C Hess
    Department of Pharmacology, Joan and Sanford Weill Medical College, Graduate School of Medical Sciences of Cornell University, New York, NY 10021, USA
    Dev Cell 9:249-59. 2005
    ..This inhibitor revealed that capacitation is defined by separable events: induction of protein tyrosine phosphorylation and motility are sAC dependent while acrosomal exocytosis is not dependent on sAC...
  14. pmc Glyceraldehyde 3-phosphate dehydrogenase-S, a sperm-specific glycolytic enzyme, is required for sperm motility and male fertility
    Kiyoshi Miki
    Laboratories for Reproductive Biology, and Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 101:16501-6. 2004
    ..Gapds(-/-) males were infertile and had profound defects in sperm motility, exhibiting sluggish movement without forward progression...
  15. ncbi Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men
    Tina Kold Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark
    Fertil Steril 82:863-70. 2004
    ..To examine the relationship between body mass index (BMI) and semen quality among young men from the general population...
  16. pmc The Rose-comb mutation in chickens constitutes a structural rearrangement causing both altered comb morphology and defective sperm motility
    Freyja Imsland
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden
    PLoS Genet 8:e1002775. 2012
    ..Rose-comb has pleiotropic effects, as homozygosity in males has been associated with poor sperm motility. We postulate that this is caused by the disruption of the CCDC108 gene located at one of the inversion ..
  17. ncbi Functional characterization of a mouse testicular olfactory receptor and its role in chemosensing and in regulation of sperm motility
    Nanaho Fukuda
    Department of Integrated Biosciences, The University of Tokyo, Chiba 277 8562, Japan
    J Cell Sci 117:5835-45. 2004
    ..Ca2+ influx in spermatozoa, did not cause sperm accumulation, indicating that chemosensing and regulation of sperm motility was due to an OR-mediated local Ca2+ increase...
  18. ncbi Inactivation of the mouse adenylyl cyclase 3 gene disrupts male fertility and spermatozoon function
    G Livera
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, 300 Pasteur Drive, Room A344, Stanford, CA 94305 5317, USA
    Mol Endocrinol 19:1277-90. 2005
    ..These data support the hypothesis that AC3 is required for normal spermatid or spermatozoa function and male fertility...
  19. pmc Deletion of murine choline dehydrogenase results in diminished sperm motility
    Amy R Johnson
    Department of Nutrition, Nutrition Research Institute, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    FASEB J 24:2752-61. 2010
    ..and Chdh(-/-) mice produced comparable amounts of sperm; the impaired fertility was due to diminished sperm motility in the Chdh(-/-) males...
  20. ncbi Behavioral response of human spermatozoa to a concentration jump of chemoattractants or intracellular cyclic nucleotides
    Anna Gakamsky
    Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Hum Reprod 24:1152-63. 2009
    ..A major question in mammalian sperm chemotaxis is whether the cells sense a chemoattractant gradient by comparing the chemoattractant concentration between time points or between spatial points...
  21. ncbi Reproductive effects in male rats exposed to diuron
    Glaura S A Fernandes
    Departamento de Biologia Celular, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, SP, Brazil
    Reprod Toxicol 23:106-12. 2007
    ....
  22. ncbi Glycolysis plays a major role for adenosine triphosphate supplementation in mouse sperm flagellar movement
    Chinatsu Mukai
    Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Meguro ku, Tokyo 153 8902, Japan
    Biol Reprod 71:540-7. 2004
    ..We assessed the contribution of mitochondrial respiration to mouse sperm motility. Mouse sperm maintained vigorous motility with high beat frequency in an appropriate solution including a ..
  23. ncbi Control of hyperactivation in sperm
    Susan S Suarez
    Department of Biomedical Sciences, T5 002B Veterinary Research Tower, Cornell University Ithaca, NY 14853, USA
    Hum Reprod Update 14:647-57. 2008
    ..Hyperactivation is characterized by high amplitude, asymmetrical flagellar bending...
  24. ncbi Implications of diversity in sperm size and function for sperm competition and fertility
    Montserrat Gomendio
    Reproductive Ecology and Biology Group, Museo Nacional de Ciencias Naturales CSIC, Madrid, Spain
    Int J Dev Biol 52:439-47. 2008
    ..Other studies have shown that in competitive contexts, males with faster swimming sperm have higher fertilization success. We conclude that the available evidence supports our original hypothesis...
  25. ncbi An inositol 1,4,5-trisphosphate receptor-gated intracellular Ca(2+) store is involved in regulating sperm hyperactivated motility
    H C Ho
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Biol Reprod 65:1606-15. 2001
    ..These data indicate that there is an IP(3)R-gated Ca(2+) store in the neck region of sperm that regulates hyperactivated motility...
  26. pmc Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility
    Mariano G Buffone
    Center for Research on Reproduction and Women s Health, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Reprod Dev 79:4-18. 2012
    ..Comprehending these processes will have a considerable impact on the management of fertility problems, the development of contraceptive methods, and, potentially, elucidation of analogous processes in other cell systems...
  27. pmc Female promiscuity promotes the evolution of faster sperm in cichlid fishes
    John L Fitzpatrick
    Centre for Evolutionary Biology, University of Western Australia, Crawley 6009, Australia
    Proc Natl Acad Sci U S A 106:1128-32. 2009
    ....
  28. pmc Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa
    Luís Korrodi-Gregório
    Laboratory of Signal Transduction, Centre for Cell Biology, Biology Department, University of Aveiro, 3810 193 Aveiro, Portugal
    BMC Cell Biol 14:15. 2013
    ..Preliminary results have shown a protein phosphatase inhibitor activity resembling PPP1R2 in bovine and primate spermatozoa...
  29. pmc Insulin/FOXO signaling regulates ovarian prostaglandins critical for reproduction
    Johnathan W Edmonds
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    Dev Cell 19:858-71. 2010
    ..Prostaglandins may be conserved sperm guidance factors and widespread downstream effectors of insulin actions that influence both reproductive and nonreproductive processes...
  30. pmc Oxidative DNA damage impairs global sperm DNA methylation in infertile men
    Ozlem Tunc
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia
    J Assist Reprod Genet 26:537-44. 2009
    ..In somatic cells oxidative damage to DNA and hyperhomocysteinaemia are linked with DNA hypomethylation. The objective of this study was to investigate if these pathologies also impair sperm DNA methylation...
  31. ncbi Effects of methylmercury on male reproductive functions in Wistar rats
    Daniela A Fossato da Silva
    Department of Morphology, Institute of Biosciences, Unesp Univ Estadual Paulista, Botucatu SP, Brazil dani
    Reprod Toxicol 31:431-9. 2011
    ..Adult male Wistar rats received 0, 0.5, 1.0 or 3.0 mg/kg/body weight/day orally, daily MeHg for 14 days. Sperm motility, the relative sperm count and transit time in the caput/corpus epididymis, were all reduced at all doses...
  32. ncbi Urogenital infection and sperm motility
    T Diemer
    Department of Urology, University Hospital, Justus Liebig University Giessen, Germany
    Andrologia 35:283-7. 2003
    ..that begin to explain the effects of bacteria and immunological events on the function of spermatozoa and sperm motility in particular...
  33. ncbi Differential concentration and time dependent effects of progesterone on kinase activity, hyperactivation and acrosome reaction in human spermatozoa
    V Sagare-Patil
    Molecular and Cellular Biology Laboratory, National Institute for Research in Reproductive Health, Indian Council of Medical Research, Mumbai, India
    Int J Androl 35:633-44. 2012
    ..We observed that low concentrations of progesterone (10 and 100 nm) induce sperm motility and activate tyrosine kinase; higher concentrations (1-10 μm) are required to induce extracellular signal ..
  34. pmc Two distinct Ca(2+) signaling pathways modulate sperm flagellar beating patterns in mice
    Haixin Chang
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Biol Reprod 85:296-305. 2011
    ..We concluded that hyperactivation, which is associated with capacitation, can be modulated by release of Ca(2+) from intracellular stores to reverse the direction of the dominant flagellar bend and, thus, redirect sperm...
  35. ncbi Absence of annulus in human asthenozoospermia: case report
    P Lhuillier
    département génétique et développement, Institut Cochin, 24 rue du Faubourg Saint Jacques, Paris 75014, France
    Hum Reprod 24:1296-303. 2009
    ..The case we studied, so far unreported in human, confirms the involvement of Tat1 and Septin proteins in the constitution of the annulus, but also raises questions about the function of this structure in human sperm motility.
  36. pmc Precious essences: female secretions promote sperm storage in Drosophila
    Mariana F Wolfner
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America
    PLoS Biol 9:e1001191. 2011
    ..Identification of these molecules also has potential practical implications for strategies to regulate the reproduction of insects of medical or agricultural importance...
  37. ncbi Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa
    Martin Blomberg Jensen
    University Department of Growth and Reproduction, Rigshospitalet, Section 5064, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Hum Reprod 26:1307-17. 2011
    ..We investigated the role of activated VD (1,25(OH)(2)D(3)) in human spermatozoa and whether VD serum levels are associated with semen quality...
  38. pmc Mammalian sperm translate nuclear-encoded proteins by mitochondrial-type ribosomes
    Yael Gur
    Faculty of Life Sciences, Bar Ilan University, Ramat Gan 52900, Israel
    Genes Dev 20:411-6. 2006
    ..Inhibition of protein translation significantly reduced sperm motility, capacitation and in vitro fertilization rate...
  39. ncbi Exposure to CB-153 and p,p'-DDE and male reproductive function
    A Rignell-Hydbom
    Department of Occupational and Environmental Medicine, Institute of Laboratory Medicine, Lund University Hospital, SE 221 85 Lund, Sweden
    Hum Reprod 19:2066-75. 2004
    ....
  40. ncbi Calcium signaling through CatSper channels in mammalian fertilization
    Dejian Ren
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Physiology (Bethesda) 25:165-75. 2010
    ..We propose that physiological stimuli such as zona pellucida and cyclic nucleotides induce Ca(2+) entry through CatSper channels instead of acting on Ca(V) and CNG channels as previously thought...
  41. ncbi Motility and protein phosphorylation in healthy and asthenozoospermic sperm
    Chying Chyuan Chan
    Graduate Institute of Medical Sciences, National Defence Medical Center, Taipei, Taiwan, ROC
    J Proteome Res 8:5382-6. 2009
    The majority of male infertility results from poor sperm motility. A direct link between altered protein phosphorylation and aberrant sperm motility has not been established...
  42. ncbi The role of mitochondria in energy production for human sperm motility
    P Piomboni
    Department of Biomedical Sciences, Applied Biology Section, University of Siena, Siena, Italy
    Int J Androl 35:109-24. 2012
    ..production of chemical energy in the form of ATP which can be used, in the case of spermatozoa, for sustaining sperm motility. The latter, on the other hand, represents one of the major determinants of male fertility...
  43. pmc Conserving, distributing and managing genetically modified mouse lines by sperm cryopreservation
    G Charles Ostermeier
    Technology Evaluation and Development, The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS ONE 3:e2792. 2008
    ..Sperm from C57BL/6 mice are difficult to cryopreserve and recover. Yet, the majority of genetically modified (GM) lines are maintained on this genetic background...
  44. ncbi Primate sperm contain protein phosphatase 1, a biochemical mediator of motility
    G D Smith
    Division of Reproductive Sciences, Oregon Regional Primate Research Center, Beaverton 97006, USA
    Biol Reprod 54:719-27. 1996
    b>Sperm motility initiation, capacitation, and hyperactivation are modulated by an interplay of intracellular Ca2+, cAMP, and pH...
  45. pmc Inhibition of human sperm motility by contraceptive anti-eppin antibodies from infertile male monkeys: effect on cyclic adenosine monophosphate
    MICHAEL G O'RAND
    Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Biol Reprod 80:279-85. 2009
    ..of anti-eppin antibodies from infertile male monkeys and the effect of recombinant human semenogelin on human sperm motility. Anti-eppin antibodies significantly decreased the progressive motility of human spermatozoa as measured by ..
  46. ncbi Loss of R2D2 proteins ROPN1 and ROPN1L causes defects in murine sperm motility, phosphorylation, and fibrous sheath integrity
    Sarah E Fiedler
    Portland Veterans Affairs Medical Center and Department of Medicine, Oregon Health and Science University, Portland, OR 97239, USA
    Biol Reprod 88:41. 2013
    ..RLKO mice had slightly reduced sperm motility and increased levels of ROPN1. RKO mice had moderately impaired motility and increased levels of ROPN1L...
  47. ncbi Male obesity and alteration in sperm parameters
    Ahmad O Hammoud
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Utah, School of Medicine, Salt Lake City, Utah 84132, USA
    Fertil Steril 90:2222-5. 2008
    ..To study the effect of male obesity on sperm parameters and erectile dysfunction...
  48. ncbi An epididymis-specific beta-defensin is important for the initiation of sperm maturation
    Chen Xi Zhou
    Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
    Nat Cell Biol 6:458-64. 2004
    ..cells, either of epididymal origin or from a Bin1b-transfected cell line, can induce progressive sperm motility in immotile immature sperm...
  49. pmc Transaldolase is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa
    Andras Perl
    Department of Medicine, College of Medicine, State University of New York, 750 East Adams Street, Syracuse, NY 13210, USA
    Proc Natl Acad Sci U S A 103:14813-8. 2006
    ..Collectively, these data reveal an essential role of TAL in sperm-cell mitochondrial function and, thus, male fertility...
  50. ncbi Calcium channels in the development, maturation, and function of spermatozoa
    Alberto Darszon
    Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
    Physiol Rev 91:1305-55. 2011
    ....
  51. ncbi Testicular toxicity in mercuric chloride treated rats: association with oxidative stress
    Mohamed Ali Boujbiha
    Laboratory of Ecophysiology of Animals, Faculty of Sciences, 3018 Sfax, BP 802, Tunisia
    Reprod Toxicol 28:81-9. 2009
    ....
  52. ncbi Cryopreservation of spermatozoa in alginic acid capsules
    Andreas Herrler
    Department of Anatomy and Reproductive Biology, Medical School, RWTH Aachen, Aachen, Germany
    Fertil Steril 85:208-13. 2006
    ..To develop a method of freezing small amounts of spermatozoa in polymerized alginic acid drops, which can be liquified after thawing for recovery of the spermatozoa...
  53. pmc An essential role for katanin p80 and microtubule severing in male gamete production
    Liza O'Donnell
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    PLoS Genet 8:e1002698. 2012
    ..Collectively these data demonstrate that katanin p80 serves an essential and evolutionarily conserved role in several aspects of male germ cell development...
  54. pmc Behavioral mechanism during human sperm chemotaxis: involvement of hyperactivation
    Leah Armon
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    PLoS ONE 6:e28359. 2011
    ..On the basis of these results a model for the behavior of spermatozoa responding to a spatial chemoattractant gradient is proposed...
  55. ncbi Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats
    Ahmet Atessahin
    Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Firat University, 23119 Elazig, Turkey
    Reprod Toxicol 21:42-7. 2006
    ..Administration of cisplatin to rats decreased sperm concentration (p < 0.05) and sperm motility (p < 0.001), increased total abnormal sperm rates (p < 0.05) as compared with the control group...
  56. ncbi Broken sperm, cytoplasmic droplets and reduced sperm motility are principal markers of decreased sperm quality due to organophosphorus pesticides in rats
    Ai Okamura
    Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Aichi 467 8601, Japan
    J Occup Health 51:478-87. 2009
    ..reports have shown significant associations between organopshophorus pesticide (OP) exposure and decreased sperm motility in workers and laboratory animals...
  57. ncbi Mechanism regulating Ca2+-dependent mechanosensory behaviour in sea urchin spermatozoa
    Yuka Kambara
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    Cell Struct Funct 36:69-82. 2011
    ..The results show that the Ca(2+)-dependent mechanosensory behaviour of the sea urchin sperm is regulated by organized functioning of the membrane environment including the plasma membrane proteins and flagellasialin...
  58. ncbi Centrifugation on a single layer of colloid selects improved quality spermatozoa from frozen-thawed stallion semen
    B Macias Garcia
    Veterinary Teaching Hospital, Laboratory of Spermatology, University of Extremadura, Avda de Universidad s n, Caceres, Spain
    Anim Reprod Sci 114:193-202. 2009
    ..b>Sperm motility, sperm chromatin structure, membrane integrity and mitochondrial membrane potential were studied in filtered ..
  59. pmc Rediscovering sperm ion channels with the patch-clamp technique
    Yuriy Kirichok
    Department of Physiology, University of California San Francisco UCSF Mail Code 2140, Genentech Hall Room N272F 600 16th Street, San Francisco, CA 94158, USA
    Mol Hum Reprod 17:478-99. 2011
    ..This method is critical for identification of the molecular mechanisms that control sperm behavior within the female reproductive tract and make fertilization possible...
  60. ncbi [Ca2+]i signalling in sperm--making the most of what you've got
    Stephen Publicover
    Stephen Publicover is in the School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK
    Nat Cell Biol 9:235-42. 2007
    ..Strangely, in a cell with few organelles and minimal cytoplasmic volume, internal Ca(2+) concentration, [Ca(2+)](i), regulates almost all these activities. How does such a simple cell achieve this - and is it as simple as it seems?..
  61. ncbi Fibrous sheath of mammalian spermatozoa
    Edward M Eddy
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Microsc Res Tech 61:103-15. 2003
    ....
  62. pmc Hypercholesterolemia impaired sperm functionality in rabbits
    Tania E Saez Lancellotti
    Laboratorio de Investigaciones Andrológicas de Mendoza, Facultad de Ciencias Medicas, Instituto de Histología y Embriología de Mendoza, Universidad Nacional de Cuyo, Centro Científico Tecnológico, Mendoza, Argentina
    PLoS ONE 5:e13457. 2010
    ..Semen examination revealed a significant reduction in semen volume and sperm motility in hypercholesterolemic rabbits (HCR)...
  63. ncbi Abnormally high body mass index and tobacco use are associated with poor sperm quality as revealed by reduced sperm binding to hyaluronan-coated slides
    Carole C Wegner
    Center for Reproductive Biology of Indiana, Indianapolis, Indiana 46280, USA
    Fertil Steril 93:332-4. 2010
    ....
  64. ncbi Clean technique for cryoprotectant-free vitrification of human spermatozoa
    Vladimir Isachenko
    Department of Endocrinology and Reproductive Medicine, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Reprod Biomed Online 10:350-4. 2005
    ....
  65. ncbi Spermatozoal transcriptome profiling for bull sperm motility: a potential tool to evaluate semen quality
    Nathalie Bissonnette
    Dairy and Swine Research and Development Center, Agriculture and Agri Food Canada, 2000 College Road, Sherbrooke, Quebec J1M 1Z3, Canada
    Reproduction 138:65-80. 2009
    ..These results demonstrate that some transcripts previously identified in association with field fertility are also found associated with in vitro motility provided that a stringent RNA extraction protocol is used...
  66. ncbi Novel method for the cryopreservation of testicular sperm and ejaculated spermatozoa from patients with severe oligospermia: a pilot study
    Alexander Just
    Department of Gynecology and Obstetrics, IVF Outpatient Department, General Hospital of St Pölten, Probst Fuhrer Strasse 4, A 3100 St Pölten, Austria
    Fertil Steril 82:445-7. 2004
    ..To investigate Volvox globator as an easy-to-handle vehicle and as a safe alternative for cryopreservation of functional motile sperm cells...
  67. ncbi Relationships between sperm motility characteristics assessed by the computer-aided sperm analysis (CASA) and fertilization rates in vitro
    Y Hirano
    Department of Obstetrics and Gynecology, Jichi Medical School, 3311 1, Yakushiji, Minamikawachi Machi, Tochigi 329 0498, Japan
    J Assist Reprod Genet 18:213-8. 2001
    ..This study was carried out to investigate the relationships between the CASA estimates and fertilization rates in vitro...
  68. ncbi The use of semen parameters to identify the subfertile male in the general population
    F H van der Merwe
    Reproductive Biology Unit, Department of Obstetrics and Gynecology, University of Stellenbosch and Tygerberg Hospital, Tygerberg, South Africa
    Gynecol Obstet Invest 59:86-91. 2005
    ..review of the literature published on semen parameters and in vivo fertility potential and to establish fertility/subfertility thresholds for sperm morphology using Tygerberg strict criteria, sperm concentration, and sperm motility.
  69. ncbi Identification of protein tyrosine phosphatases and dual-specificity phosphatases in mammalian spermatozoa and their role in sperm motility and protein tyrosine phosphorylation
    L Gonzalez-Fernandez
    Cell Physiology Research Group, Laboratory of Spermatology, University of Extremadura, Caceres, Spain
    Biol Reprod 80:1239-52. 2009
    ..investigate the roles of tyrosine phosphatases in maintenance of protein tyrosine phosphorylation level and in sperm motility. Using Western blotting with specific antibodies in boar and stallion sperm lysates, we unequivocally ..
  70. ncbi Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility
    I Mor
    The Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
    J Cell Mol Med 12:479-95. 2008
    ..In human donors' sperm, we found direct association of sperm motility with AChE-R expression...
  71. ncbi Sperm nuclear vacuoles, as assessed by motile sperm organellar morphological examination, are mostly of acrosomal origin
    O Kacem
    Service d Histologie Embryologie Biologie de la Reproduction, Hopital Cochin, AP HP, 123, Bd Port Royal 75013 Paris, Universite Paris Descartes, France
    Reprod Biomed Online 20:132-7. 2010
    ....
  72. ncbi Beyond the mouse model: using Drosophila as a model for sperm interaction with the female reproductive tract
    Y Heifetz
    Entomology, Hebrew University, Rehovot, Israel
    Theriogenology 73:723-39. 2010
    ..Furthermore, we discuss how the study of multiple sperm storage organ types in Drosophila may help us identify factors essential for sperm viability and, moreover, factors that promote long-term sperm survivorship...
  73. pmc Sperm competition dynamics: ejaculate fertilising efficiency changes differentially with time
    Tommaso Pizzari
    Edward Grey Institute, Department of Zoology, University of Oxford, Oxford, UK
    BMC Evol Biol 8:332. 2008
    ..The differential rate at which rival ejaculates lose their fertilising efficiency over time is therefore expected to influence the outcome of sperm competition...
  74. ncbi Correlation between DNA damage and sperm parameters: a prospective study of 1,633 patients
    Paul Cohen-Bacrie
    Laboratoire d Eylau, Paris, France
    Fertil Steril 91:1801-5. 2009
    ....
  75. pmc Sperm preparation for ART
    Ralf R Henkel
    Department of Dermatology and Andrology, Justus Liebig University, Giessen, Gaffkystr, 14, Germany
    Reprod Biol Endocrinol 1:108. 2003
    ..The older method, by which the ejaculate is forcefully aspirated through a narrow-gauge needle, should be abandoned as it can severely damage spermatozoa, thus resulting in immotile sperm...
  76. ncbi Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility
    Nathalie Bedard
    Polypeptide Laboratory, Department of Medicine, McGill University and McGill University Health Centre, Montreal, Quebec, Canada
    Biol Reprod 85:594-604. 2011
    ..We demonstrate for the first time, using mouse transgenic approaches, a role for the ubiquitin system in fertilization...
  77. ncbi Targeted disruption of the Akap4 gene causes defects in sperm flagellum and motility
    Kiyoshi Miki
    Gamete Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences NIH, Research Triangle Park, NC 27709, USA
    Dev Biol 248:331-42. 2002
    ..Previous studies indicated that cyclic AMP-dependent signaling processes are important in the regulation of sperm motility, and gene targeting was used here to test the hypothesis that AKAP4 is a scaffold for protein complexes ..
  78. pmc The epididymis, cytoplasmic droplets and male fertility
    Trevor G Cooper
    Centre of Reproductive Medicine and Andrology, University of Munster, Munster D 48149, Germany
    Asian J Androl 13:130-8. 2011
    ..This may reflect their short midpiece, approximating head length, permitting a swollen droplet to extend along the entire midpiece; this not only obviates droplet migration and flagellar angulation but also hampers droplet loss...
  79. ncbi Analysis of the three-dimensional trajectories of organisms: estimates of velocity, curvature and torsion from positional information
    H C Crenshaw
    Department of Zoology, Duke University, Box 90325, Durham, NC 27708 0325, USA
    J Exp Biol 203:961-82. 2000
    ....
  80. ncbi Hyperactivated motility of bull sperm is triggered at the axoneme by Ca2+ and not cAMP
    Han Chen Ho
    Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Dev Biol 250:208-17. 2002
    ..9-8.5). These results suggest that, provided sufficient ATP is present and pH is sufficiently alkaline, Ca2+ switches on hyperactivation by enabling curvature of the principal bends to increase...
  81. ncbi Ca2+ signaling tools acquired from prostasomes are required for progesterone-induced sperm motility
    Kwang Hyun Park
    Department of Biochemistry, Chonbuk National University Medical School, JeonJu 561 180, Korea
    Sci Signal 4:ra31. 2011
    Progesterone-induced calcium ion (Ca2+) signals in the neck region of sperm play a pivotal role in promoting sperm motility. Here, we show that a long-lasting Ca2+ signal required for sperm motility in response to progesterone depends on ..
  82. ncbi The effect of ascorbic acid supplementation on sperm quality, lipid peroxidation and testosterone levels of male Wistar rats
    Mustafa Sonmez
    Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Firat University, 23119 Elazig, Turkey
    Theriogenology 63:2063-72. 2005
    ..05) in the ascorbic acid treated animals when compared to the control animals. The results suggest that ascorbic acid supplementation improves reproductive traits of male rats that are associated with high fertility...
  83. ncbi Role of glutathione peroxidase in protecting mammalian spermatozoa from loss of motility caused by spontaneous lipid peroxidation
    J G Alvarez
    Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, 19104 6080
    Gamete Res 23:77-90. 1989
    ..Recent work has shown that loss of sperm motility in these species correlates with the extent of spontaneous lipid peroxidation...
  84. pmc Compartmentalization of a unique ADP/ATP carrier protein SFEC (Sperm Flagellar Energy Carrier, AAC4) with glycolytic enzymes in the fibrous sheath of the human sperm flagellar principal piece
    Young Hwan Kim
    Center for Research in Contraceptive and Reproductive Health, Department of Cell Biology, University of Virginia, Charlottesville, PO Box 800732, VA 22908, USA
    Dev Biol 302:463-76. 2007
    ....
  85. ncbi Semen parameters, including WHO and strict criteria morphology, in a fertile and subfertile population: an effort towards standardization of in-vivo thresholds
    R Menkveld
    Reproductive Biology Unit, Department of Obstetrics and Gynaecology, Tygerberg Hospital and University of Stellenbosch, Tygerberg, 7505 South Africa
    Hum Reprod 16:1165-71. 2001
    ..For motility, the new cut-off value was at 20% motile spermatozoa, for motility quality at 3.5 (on a scale of 1-6), the acrosome index at 3% normal acrosomes, and the teratozoospermia index at 2.09...
  86. ncbi Mechanisms of sperm chemotaxis
    U Benjamin Kaupp
    Forschungszentrum Julich, Institut für Neurowissenschaften und Biophysik 1, D 52425 Julich, Germany
    Annu Rev Physiol 70:93-117. 2008
    ..In this review, we raise new questions and discuss current concepts of sperm chemotaxis. Finally, we highlight commonalities and differences of sensory signaling in sperm, photoreceptors, and olfactory neurons...
  87. ncbi Identification of several proteins involved in regulation of sperm motility by proteomic analysis
    Chun Zhao
    Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, People s Republic of China
    Fertil Steril 87:436-8. 2007
    ..These proteins may play roles in the regulation of sperm motility, and their characterization could merit further investigation on sperm motility-related male factor infertility...
  88. ncbi Is prenatal exposure to tobacco smoking a cause of poor semen quality? A follow-up study
    Cecilia Høst Ramlau-Hansen
    Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark
    Am J Epidemiol 165:1372-9. 2007
    ..68, 6.87) among exposed men compared with the unexposed. No associations were found for sperm motility or morphology...
  89. pmc Cystic fibrosis transmembrane conductance regulator is vital to sperm fertilizing capacity and male fertility
    Wen Ming Xu
    Epithelial Cell Biology Research Center, Li Ka Shing Institute of Health Sciences, Department of Physiology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Proc Natl Acad Sci U S A 104:9816-21. 2007
    ....
  90. ncbi Epididymosomes are involved in the acquisition of new sperm proteins during epididymal transit
    Robert Sullivan
    Centre de Recherche en Biologie de la Reproduction and Département d Obstétrique Gynécologie, Universite Laval, Quebec, Canada
    Asian J Androl 9:483-91. 2007
    ..In conclusion, epididymosomes are small membranous vesicles secreted in an apocrine manner in the intraluminal compartment of the epididymis and play a major role in the acquisition of new proteins by the maturing spermatozoa...
  91. ncbi A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility
    Dan Wang
    Cecil H and Ida Green Center for Reproductive Biology Sciences, Howard Hughes Medical Institute, and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9051, USA
    Nat Cell Biol 5:1117-22. 2003
    It has long been speculated that intracellular pH is a critical regulator of both invertebrate and vertebrate sperm motility, and sodium-hydrogen exchange has been suggested as a mediator of such pH(i) regulation in various instances...
  92. pmc Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicity
    Burhan I Ghanayem
    Laboratory of Pharmacology, Biostatistics Branch, and Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Biol Reprod 82:96-104. 2010
    ..This work demonstrated that diet-induced obesity in mice caused a significant reduction in male fertility and exacerbated AA-induced reproductive toxicity and germ cell mutagenicity...
  93. ncbi Glycolysis and sperm motility: does a spoonful of sugar help the flagellum go round?
    W C L Ford
    Department of Clinical Science at South Bristol, St Michael s Hospital, University of Bristol, Bristol, UK
    Hum Reprod Update 12:269-74. 2006
    ..In most species, it is unlikely that local glycolysis is the only way that ATP can be supplied to the distal flagellum...
  94. pmc AKAP3 selectively binds PDE4A isoforms in bovine spermatozoa
    Malini Bajpai
    Department of Medicine, Oregon Health and Sciences University and VA Medical Center, Portland, OR 97239, USA
    Biol Reprod 74:109-18. 2006
    Cyclic AMP plays an important role in regulating sperm motility and acrosome reaction through activation of cAMP-dependent protein kinase A (PKA)...
  95. pmc The t-complex-encoded guanine nucleotide exchange factor Fgd2 reveals that two opposing signaling pathways promote transmission ratio distortion in the mouse
    Hermann Bauer
    Max Planck Institute for Molecular Genetics, Department of Developmental Genetics, Berlin 14195, Germany
    Genes Dev 21:143-7. 2007
    ..by the cooperative effect of four t-complex distorters (Tcd1-4) and the single t-complex responder (Tcr) on sperm motility. Here we show that Fgd2, encoding a Rho guanine nucleotide exchange factor, maps to the Tcd2 region...
  96. ncbi An aminoglycoside antibiotic gentamycin induces oxidative stress, reduces antioxidant reserve and impairs spermatogenesis in rats
    Kilarkaje Narayana
    Department of Anatomy, Faculty of Medicine, HSC, Kuwait University, Safat, Kuwait
    J Toxicol Sci 33:85-96. 2008
    ..The sperm count, sperm motility and incidence of abnormal sperms were estimated in the epididymis...
  97. ncbi Effect of Mucuna pruriens on semen profile and biochemical parameters in seminal plasma of infertile men
    Mohammad Kaleem Ahmad
    Department of Biochemistry, King George s Medical University, Lucknow, India
    Fertil Steril 90:627-35. 2008
    ..To investigate the impact of Mucuna pruriens seeds on semen profiles and biochemical levels in seminal plasma of infertile men...
  98. ncbi Ketamine effects on the urogenital system--changes in the urinary bladder and sperm motility
    Sijie Tan
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
    Microsc Res Tech 74:1192-8. 2011
    ..was used as the dose for the study in the toxicity of long-term ketamine administration on urinary bladder and sperm motility. The treatment group were subdivided into two (n = 10 each group); one received daily ketamine treatment i.p...
  99. ncbi Sperm motility: is viscosity fundamental to progress?
    Jackson C Kirkman-Brown
    The Centre for Human Reproductive Science, Birmingham Women s Hospital, Edgbaston, Birmingham, UK
    Mol Hum Reprod 17:539-44. 2011
    ..The physiological effects of viscosity are also crucial to consider when designing and extrapolating data from in vitro experiments to the in vivo situation...
  100. ncbi Cryopreservation and sperm DNA integrity
    L Gandini
    Laboratory of Seminology and Reproductive Immunology, Department of Medical Pathophysiology, University of Rome La Sapienza, 00100, Rome, Italy
    Cell Tissue Bank 7:91-8. 2006
    ..Overall sperm quality was found to deteriorate after cryopreservation. When thawed spermatozoa were subjected to an extra swim-up round, a general improvement in nuclear maturity was seen in post-rise spermatozoa...
  101. ncbi Adverse effects of hepatitis B virus on sperm motility and fertilization ability during IVF
    Pierre Oger
    Bichat Claude Bernard University Hospital, Obstetrics, Gynecology and Reproductive Medicine Dept, 46 rue Henri Huchard, 75018 Paris, France
    Reprod Biomed Online 23:207-12. 2011
    ..b>Sperm motility before selection was significantly reduced in the HBV group (36.3 ± 11.6% versus 45.3 ± 14.4%,P = 0.003)...

Research Grants62

  1. Regulation of insulins by the Rhox5 homeobox gene supports spermatogenesis
    James Maclean; Fiscal Year: 2009
    ..these genes, Rhox5 (Pem), results in male subfertility, marked by increased germ-cell apoptosis and abnormal sperm motility. To begin to uncover the molecular events triggered by Rhox5 in Sertoli cells, I used microarray analysis to ..
  2. THE EFFECT OF DIOXINS ON GLUCOSE HOMEOSTASIS IN MURINE TESTES
    KENAN RIFAT OMURTAG; Fiscal Year: 2013
    ..Previous study in our lab has shown several functional detriments to spermatogenesis, sperm motility, and fertilization capability in mice affected with disruptions in glucose homeostasis...
  3. Regulation and Function of the Rhox5 Homeobox Gene
    MILES FROME WILKINSON; Fiscal Year: 2013
    ..Loss of Rhox5 in mice loss causes increased male germ-cell apoptosis, reduced sperm count, and reduced sperm motility. Because Rhox5 is expressed in Sertoli cells, this suggests that Rhox5 regulates the transcription of genes ..
  4. Secretory Vesicle Function During Spermatogenesis & Fertilization in C. elegans
    STEVEN W L apos HERNAULT; Fiscal Year: 2010
    ..Specific aim #2 is to identify how absence of V-ATPase function affects sperm motility and function during fertilization...
  5. Structural Targeting Testis Specific Kinases (TSSK) 1 &2 for Male Contraception
    John C Herr; Fiscal Year: 2013
    ..Deficiency of SPAG16L causes male infertility associated with impaired sperm motility, These key findings substantiate an indispensable role for TSSK 1 &2 and the TSSK 1 &2 pathway in ..
  6. MOLECULAR BASIS OF MAMMALIAN SPERM MOTILITY
    Jerome F Strauss; Fiscal Year: 2010
    ..This knowledge will provide a molecular framework for understanding sperm motility defects causing male infertility and the function of "9+2" cilia in general...
  7. Cyclic AMP Action During Sperm Function
    George L Gerton; Fiscal Year: 2012
    ..of the two genotypes, and, 3) determine the role that EPACs, a family of cAMP-activated proteins, have on sperm motility. The fact that fertilization does not occur without proper sperm maturation in the epididymis and sperm ..
  8. Developing Male Contraceptives by Targeting ANT4
    Naohiro Terada; Fiscal Year: 2013
    ..2) The 300 highest-scoring compounds will be screened for their ability to inhibit sperm motility in non-glycolytic conditions...
  9. Dissection of the structural basis of MEIG1 in assembling sperm flagella
    Zhibing Zhang; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Motility enables sperm to reach the egg for fertilization, and normal sperm motility is largely dependent on formation and function of the flagella...
  10. Prostaglandins in C. elegans Fertilization
    Michael A Miller; Fiscal Year: 2013
    ..In addition, prostaglandins can regulate sperm motility in the absence of PUFAs...
  11. Molecular Mechanisms of Endocrine Disruption in Bass
    Nancy D Denslow; Fiscal Year: 2011
    ..endpoints including the ability of eggs to mature (germinal vesicle breakdown) and sperm function (sperm motility)...
  12. Trichomonas vaginalis MIF: a role in prostate cancer and infertility?
    PATRICIA JEAN JOHNSON; Fiscal Year: 2013
    ..of TvMIF on prostate cell proliferation and tumorogenesis (Aim 2) and to test the ability of TvMIF to inhibit sperm motility (Aim 3)...
  13. The molecular mechanisms by which mammalian Fused regulates motile cilia function
    Pao Tien Chuang; Fiscal Year: 2012
    ..processes including mucociliary clearance in the respiratory system, cerebrospinal fluid (CSF) circulation and sperm motility. Dysfunction of motile cilia and flagella underlies the human syndrome of primary ciliary dyskinesia (PCD)...
  14. Cooperative Multicenter Reproductive Medicine Network UNC Clinical Site
    ANNE ZWEIFEL STEINER; Fiscal Year: 2013
    ..is a randomized controlled trial designed to test the hypothesis that male antioxidant therapy will improve sperm motility and reduce DNA fragmentation leading to higher fertilization and lower miscarriage rates in couples trying to ..
  15. AMERICAN SOCIETY OF ANDROLOGY ANNUAL MEETING
    Dolores J Lamb; Fiscal Year: 2010
    ..address "Issues in Male Sexual Health: From Benchmark to Bedside" with a focus on physiology and treatment of sexual dysfunction, and a 1-day "hands- on" Andrology Lab Workshop on semen analysis with a focus on sperm motility evaluation.
  16. Pre-Clinical HPV16 Antiviral Compound Development
    Christopher Fisher; Fiscal Year: 2010
    ..CL formulations for additional pilot toxicity and pharmacokinetic studies, including vaginal irritation and sperm motility assays;4) scale-up chemical synthesis and formulation of the CL, determination of a GLP Certificate of ..
  17. 2011 Fertilization and Activation of Development Gordon Research Conference
    Janice P Evans; Fiscal Year: 2011
    ..exposures, assisted reproductive technologies), effects of the reproductive tract environment on the gametes, sperm motility and chemotaxis, sperm entry into the egg, egg activation signals and events, and processes mediating ..
  18. Adenine Nucleotide Metabolism and Signaling in Mammalian Sperm
    George L Gerton; Fiscal Year: 2013
    ..Besides basal sperm motility, key sperm functions such as capacitation and hyperactivated motility rely on the use of adenine nucleotides ..
  19. Regulation of sperm motility by the Rho signaling pathway
    Daniel W Carr; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Suboptimal sperm motility accounts for nearly 30% of all human infertility...
  20. SLO3 KO MOUSE: A TOOL TO REVEAL VOLTAGE-DEPENDENT PROCESSES IN SPERM FERTILITY
    CELIA MARIA SANTI; Fiscal Year: 2013
    ..We also demonstrated that sperm from SLO3 -/- mice have major deficits in sperm motility as well as in the Acrosome Reaction (AR)...
  21. Developing Selective Inhibitors of GAPDHS and Sperm Glycolysis for Contraception
    DEBORAH A O'BRIEN; Fiscal Year: 2013
    ..GAPDHS), are promising contraceptive targets because they are specific to male germ cells, essential for sperm motility and male fertility, and are well suited to pharmacological inhibition...
  22. 2013 Fertilization and Activation of Development GRC/GRS
    PABLO EDUARDO VISCONTI; Fiscal Year: 2013
    ..exposures, assisted reproductive technologies), effects of the reproductive tract environment on the gametes, sperm motility and chemotaxis, sperm entry into the egg, egg activation signals and events, and processes mediating ..
  23. AMOEBOID MOTILITY--A CELLULAR AND GENETIC APPROACH
    Thomas M Roberts; Fiscal Year: 2010
    ..unique filaments have no structural polarity indicating that molecular motor proteins are not required for sperm motility. The coupling of MSP cytoskeletal dynamics to locomotion suggests a "push-pull" mechanism for movement in ..
  24. Development of Eppin as a Male Contraceptive
    MICHAEL G O'RAND; Fiscal Year: 2013
    ..of eppin with semenogelin on the human sperm surface, particularly with regard to the resumption of sperm motility following ejaculation...
  25. Role of the Na, K-ATPase Alpha4 Isoform in Sperm Motility
    Paul James; Fiscal Year: 2009
    ..sperm and examine the role that isoforms of the NHE and other Na,K-ATPase isoforms play in maintaining sperm motility. We will also characterize the Na,K-ATPase alpha4 isoform from humans with respect to its tissue distribution ..
  26. Analysis of an NHE inhibitor signaling pathway that regulates sperm motility.
    Paul F James; Fiscal Year: 2010
    ..While the roles that structural/motor proteins and ion channels play in sperm motility is under intense investigation and is beginning to become clear, the roles that active membrane transporters ..
  27. Soluble adenylyl cyclase isoforms essential for male fertility
    Lonny R Levin; Fiscal Year: 2013
    ..their deletion (in Sacytm1Lex knockout mice) or inhibition (by small molecule, sAC-specific inhibitor) blocks sperm motility, capacitation, and in vitro fertilization...
  28. Function of a voltage-sensitive phosphatase in the regulation of sperm-egg fusion
    Laurinda A Jaffe; Fiscal Year: 2011
    ..Alternatively, localization in the tail region would support its role in the regulation of sperm motility. Specific aim two will investigate the function of the VSP, using a transgenic frog whose sperm express a ..
  29. Collaborative Cross: A system genetics approach to the study of male infertility
    Fernando Pardo-Manuel de Villena; Fiscal Year: 2013
    ..variation for major male reproductive traits including abnormal testis histology, testis weight, sperm count, sperm motility and infertility;and 3) provide independent validation of the infertility loci mapped in the extinct funnels, ..
  30. Male Subfertility By Ni2+ Poisoning of Ca2+ Channels ?
    Susan Benoff; Fiscal Year: 2001
    ..In preliminary studies, even though nanomolar Ni2+ concentrations have no effect upon human sperm motility, supplementing in vitro incubation media with nanomolar Ni2+ markedly decreased human sperms' response to ..
  31. MALE INFERTILITY: SPERM MOTILITY AND AXONEMAL STABILITY
    REGINA TURNER; Fiscal Year: 2001
    ..Reduced or absent sperm motility is a common feature in cases of male factor infertility; however, the molecular mechanisms underlying the ..
  32. A Novel Device Design for Sperm Cryopreservation
    ERIK WOODS; Fiscal Year: 2009
    ..Ultimate feasibility of this proposed novel system will be considered achieved if 60% post-thaw mouse and rat sperm motility is achieved...
  33. ASSESSMENT OF GENETIC DAMAGE INDUCED BY CHEMOTHERAPY
    JAN LIANG; Fiscal Year: 1992
    ..Human studies will involve determinations of sperm count, sperm motility, sperm morphology and chromosomal constitutions in semen samples of patients that have been treated with MOPP ..
  34. Role of Cyclic Nucleotides in Sperm Function
    Marco Conti; Fiscal Year: 2009
    ..both biochemical and genetic approaches to investigate the components of this pathway, as well as its role in sperm motility. We determined that at least two adenylyl cyclases, a membrane-bound AC3 and soluble adenylyl cyclases (sAC), ..
  35. SPERM MEMBRANE CHANGES WITH MATURATION AND CAPACITATION
    David Wolf; Fiscal Year: 1990
    ..important physiological alterations which occur in the male and female tracts, specifically the development of sperm motility, the acrosome reaction, and the potential to fertilize ova...
  36. 1991 TESTIS WORKSHOP
    Bernard Robaire; Fiscal Year: 1991
    ..Finally, the application of the technical breakthroughs in our understanding of sperm motility and of the underlying processes of sperm-egg interaction will be presented...
  37. A NOVEL PH DEPENDENT POTASSIUM CHANNEL IN MAMMALIAN SPERM
    Celia Santi; Fiscal Year: 2009
    ..from the loss of SLO3 channels with respect to the fertility of the K/O mouse, the production of sperm cells, sperm motility, sperm capacitation, the acrosome reaction and volume regulation of sperm...
  38. PRIMATE SPERM ANTIGENS AS IMMUNOCONTRACEPTIVE VACCINES
    Don Wolf; Fiscal Year: 1990
    ..While assessments of human sperm motility and acrosomal status are possible by in vitro approaches, the fertilization of human oocytes is precluded on ..
  39. EPIDEMIOLOGY OF MALE INFERTILITY: CRYPTORCHIDISM
    Peter Lee; Fiscal Year: 1999
    ..Sperm analyses will be done in collaboration with the Reproductive Health Network including videotaping of sperm motility for computer analysis...
  40. Fertilization and Activation of Development 2007 Gordon Research Conference
    GEORGE GERTON; Fiscal Year: 2007
    ..maturation of sperm; 2) The role of the female reproductive tract in gamete interactions; 3) Chemotaxis and Sperm Motility; 4) Sperm-egg interactions; 5) Sperm signaling; 6) Oocyte to Embryo Transition; 7) Polarity of egg and early ..
  41. SPERM TRANSPORT IN THE FEMALE RABBIT
    James Overstreet; Fiscal Year: 1980
    ..mating by cryptorchid males and artificial insemination of immotile sperm will clarify the importance of sperm motility for entry into the cervix and passage to the oviducts during rapid sperm transport...
  42. THE STRUCTURAL BASIS OF RELAXIN ACTION
    Christian Schwabe; Fiscal Year: 1990
    ..in that the implantation of an ovum into the endometrium appears to be a relaxin-mediated process and sperm motility appears to be enhanced in the presence of relaxin...
  43. THE EPIDIDYMAL INITIATION OF SPERM MOTILITY
    DALE HOSKINS; Fiscal Year: 1991
    ..AMP, and pHi in caput sperm while simultaneously measuring the levels of all other factors and monitoring sperm motility. In this and all studies in the proposal we will monitor both sperm head and flagellar movement parameters by ..
  44. CatSper: Novel target for an oral contraceptive
    JAYHONG CHONG; Fiscal Year: 2003
    ..D./ Ph.D., of a sperm specific ion channel, CatSper. Male mice lacking CatSper have poor sperm motility and are sterile. These and other studies carried out by Dr...
  45. 2005 Fertilization and Activation of Development Gordon Conference
    RICHARD CARDULLO; Fiscal Year: 2005
    ..will focus on: 1) Bioinformatic, genomic, and proteomic approaches to fertilization and development; 2) Sperm motility and chemotaxis; 3) Gamete maturation; 4) Functional membrane domains in gametes; 5) Molecular aspects of sperm-..
  46. The Role of Serine Protease Inhibitors in Fertility
    Li Mei Chen; Fiscal Year: 2003
    ..the effects of the prostasin-binding protein on sperm capacitation and/or acrosomal reaction, as well as sperm motility, (2) to establish the genetic identity of this new protein by cloning the cDNA from mouse...
  47. REGULATION AND CONTROL OF HUMAN SPERM MOTILITY
    Srinivasan Vijayaraghavan; Fiscal Year: 1992
    The goal of this application is to determine the biochemical basis for the loss of human sperm motility following cryopreservation and to prevent or reverse this loss...
  48. ACTIVATION OF PROSTATE SPECIFIC ANTIGEN PRECURSOR
    Thomas Takayama; Fiscal Year: 2000
    ..It has been implicated in infertility because men with highly viscous semen have abnormal sperm motility and are often infertile...
  49. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    Becky Marquez; Fiscal Year: 2004
    ..Hyperactivation, a vigorous type of sperm motility, is found in the oviduct at time of fertilization...
  50. THE VISCOELASTICITY AND PROTEIN COMPOSITIONS OF CERVIX
    Chi Lee; Fiscal Year: 2000
    ..already exit between the levels of various mucin and protein components of mucus and viscoelasticity and sperm motility. It is suggested that EDTA may also affect such compositional changes physical properties and may also alter ..
  51. Ubiquitin-Based Semen Qualtiy Assay in Toxicology
    Peter Sutovsky; Fiscal Year: 2001
    ..count, morphology), assessed by highly subjective morphological evaluation, or at best, by computerized sperm motility analysis. I have shown previously that selective ubiquitination, i.e...
  52. Purchase of a large format CCD camera for 3-D EM
    Kenneth Taylor; Fiscal Year: 2005
    ..funded projects that will be enhanced by this equipment include the following: electron tomography of Ascaris sperm motility complexes, SIV and HIV viruses, insect flight muscle, cell adhesion complexes and adeno-associated virus...
  53. A COORDINATED PROGRAM IN REPRODUCTIVE BIOLOGY
    GEORGE GERTON; Fiscal Year: 2006
    ..Signaling in Embryos) focus on critical events in the achievement of pregnancy including spermatogenesis, sperm motility and capitation, the endocrine support of the reproductive tract by ovarian and placental steroid hormones, ..
  54. SOLUBLE ADENYLYL CYCLASE ACTIVITY IN MALE GERM CELLS
    LONNY LEVIN; Fiscal Year: 2004
    ..cyclase in mammals, the investigators propose that it is an excellent candidate to play roles in aspects of sperm motility, capacitiation and the acrosome reaction...
  55. CHARACTERIZATION OF FLAGELLAR PROTEINS INVOLVED IN SPER*
    Rossana Sapiro; Fiscal Year: 2006
    ..Mice lacking Spag6 are infertile due to a severe sperm motility defect, resulting in part from disruption of the flagellar axoneme architecture...
  56. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  57. FLP-102: Rationally Engineered Antiviral Protein
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The preclinical data on FLP-102 will be essential to further explore the utility of this novel recombinant PAP mutant for Phase II. ..
  58. PHI-443: Novel Non-Spermicidal Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of PHI-443 in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  59. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of STAMP in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  60. PHI 346: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..