Genomes and Genes
Summary: Formation of MYELOID CELLS from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW via MYELOID STEM CELLS. Myelopoiesis generally refers to the production of leukocytes in blood, such as MONOCYTES and GRANULOCYTES. This process also produces precursor cells for MACROPHAGE and DENDRITIC CELLS found in the lymphoid tissue.
Publications233 found, 100 shown here
- The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin signaling network and the control of normal myelopoiesisAlberto M Martelli
Department of Human Anatomy, University of Bologna, Bologna, Italy
Histol Histopathol 25:669-80. 2010..We then further highlight the key role played by the PI3K/Akt/mTOR network during erythropoiesis, megakaryocytopoiesis, and granulo-cytopoiesis/monocytopoiesis...
- A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesisFrancesco Fazi
Department of Histology and Medical Embryology, University of Rome La Sapienza and San Raffaele Biomedical Science Park of Rome, Via di Castel Romano 100, 00128, Rome, Italy
Cell 123:819-31. 2005..Altogether, our data indicate that miR-223 plays a crucial role during granulopoiesis and point to the NFI-A repression as an important molecular pathway mediating gene reprogramming in this cell lineage...
- Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoproteinFrancesco Fazi
Department of Histology and Medical Embryology, University La Sapienza, Rome, 00161, Italy
Cancer Cell 12:457-66. 2007..myeloid leukemia-associated fusion protein, display low levels of a microRNA-223 (miR-223), a regulator of myelopoiesis. Here, we show that miR-223 is a direct transcriptional target of AML1/ETO...
- A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA clusterXueqing Zhang
Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA 01655, USA
Blood 113:2526-34. 2009..These findings suggest that HOTAIRM1 plays a role in the myelopoiesis through modulation of gene expression in the HOXA cluster.
- miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesisNada Sonda
Department of Surgery, Oncology and Gastroenterology, Oncology and Immunology Section, University of Padua, 35128 Padua, Italy
Immunity 38:1236-49. 2013Tumor progression is accompanied by an altered myelopoiesis causing the accumulation of immunosuppressive cells...
- Irf8 regulates macrophage versus neutrophil fate during zebrafish primitive myelopoiesisLi Li
State Key Laboratory of Molecular Neuroscience, Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People s Republic of China
Blood 117:1359-69. 2011..One key unresolved question is what factors dictate polymorphonuclear versus mononuclear lineage fates during myelopoiesis. Here we show that during zebrafish embryogenesis interferon regulatory factor-8 (irf8) is expressed ..
- Myelopoiesis in spleen-producing distinct dendritic-like cellsJonathan K H Tan
Research School of Biology, The Australian National University, Canberra, ACT, Australia
J Cell Mol Med 16:1924-33. 2012..A model is advanced for development of L-DC directly from haematopoietic progenitors in spleen and dependent on the spleen microenvironment...
- The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigeneticsO Abdel-Wahab
Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Leukemia 27:10-5. 2013..Here, we highlight recent work revealing the critical function of BAP1 in restricting myelopoiesis and in regulating hematopoietic stem cell function...
- Regulation of myeloid development and function by colony stimulating factorsDaniel R Barreda
Department of Biological Sciences, CW 405 Biological Sciences Building, University of Alberta, Edmonton, AB, Canada T6G 2E9
Dev Comp Immunol 28:509-54. 2004..Although most of available knowledge about CSFs is on human and mouse CSFs, an attempt was made to integrate recent findings in other systems in order to highlight a more widespread role for CSFs throughout evolution...
- Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via β-adrenergic induction of myelopoiesisNicole D Powell
Division of Oral Biology, College of Dentistry, The Ohio State University, Columbus, OH
Proc Natl Acad Sci U S A 110:16574-9. 2013..These results suggest that sympathetic nervous system-induced up-regulation of myelopoiesis mediates the proinflammatory component of the leukocyte CTRA dynamic and may contribute to the increased risk ..
- CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapyKathleen M Sakamoto
Division of Hematology Oncology, Gwynne Hazen Cherry Memorial Laboratories, Mattel Children s Hospital UCLA, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
Clin Cancer Res 15:2583-7. 2009..Although transcription factors have not been a central focus of drug development, recent advances suggest that CREB and other such proteins may be worthwhile targets for cancer therapy...
- Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesisFrederic Pendino
Department of Molecular Biology, University of Bergen, Bergen, Norway
Blood 113:3172-81. 2009..RINF expression correlates with retinoid-induced differentiation of leukemic cells and with cytokine-induced myelopoiesis of normal CD34(+) progenitors...
- Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesisWendy J van Zuylen
The University of Queensland, Institute for Molecular Bioscience, Queensland, Australia
PLoS ONE 6:e15723. 2011..Little is known of their function, but previous studies suggest roles in immune cell development. In this report, we assessed Slfn regulation and function in macrophages, which are key cellular regulators of innate immunity...
- MicroRNA control of myelopoiesis and the differentiation block in acute myeloid leukaemiaCatalina A Palma
Blood, Stem Cells and Cancer Research, St Vincent s Hospital Centre for Applied Medical Research, St Vincent s Hospital, Darlinghurst, NSW, Australia
J Cell Mol Med 16:978-87. 2012....
- Cutting edge: Type I IFN drives emergency myelopoiesis and peripheral myeloid expansion during chronic TLR7 signalingMatthew B Buechler
Department of Immunology, University of Washington, Seattle, WA 98195, USA
J Immunol 190:886-91. 2013..In the bone marrow, TLR7.1 mice exhibited hallmarks of emergency myelopoiesis and contained a discrete population of Sca-1(+) GMP, termed emergency GMP, which are more proliferative and ..
- The emerging role of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling network in normal myelopoiesis and leukemogenesisAlberto M Martelli
Department of Human Anatomy, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
Biochim Biophys Acta 1803:991-1002. 2010..emanating from the PI3K/Akt/mTOR cascade with the functions of hematopoietic stem cells and the process of myelopoiesis, including lineage commitment...
- Reintroduction of C/EBPalpha in leukemic CD34+ stem/progenitor cells impairs self-renewal and partially restores myelopoiesisHein Schepers
Division of Hematology, Department of Medicine, University Medical Center Groningen, Groningen, The Netherlands
Blood 110:1317-25. 2007..Together, our data indicate that low C/EBPalpha levels are necessary to maintain self-renewal and the immature character of AML stem cells...
- Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesisVitalyi Senyuk
Department of Medicine, and Cancer Research Center, University of Illinois, Chicago, IL 60621, USA
Proc Natl Acad Sci U S A 110:5594-9. 2013..Ectopic expression of miR-9 strongly accelerates terminal myelopoiesis and promotes apoptosis in vitro and in vivo...
- Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosisPrabhakara R Nagareddy
Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University, New York, NY 10032, USA
Cell Metab 17:695-708. 2013..with the receptor for advanced glycation end products on common myeloid progenitor cells, leads to enhanced myelopoiesis. Treatment of hyperglycemia reduces monocytosis, entry of monocytes into atherosclerotic lesions, and promotes ..
- Mutant-specific gene programs in the zebrafishGerhard J Weber
Children s Hospital Stem Cell Program, Department of Hematology Oncology, Howard Hughes Medical Institute, Karp 7, 1 Blackfan Circle, Boston, MA 02115, USA
Blood 106:521-30. 2005....
- Transcription of proteinase 3 and related myelopoiesis genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosisChris Cheadle
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Arthritis Rheum 62:1744-54. 2010..The aim of this study was to understand the biology underlying WG and to discover markers of disease activity that would be useful for prognosis and treatment guidance...
- Cdc42 critically regulates the balance between myelopoiesis and erythropoiesisLinda Yang
Division of Experimental Hematology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
Blood 110:3853-61. 2007..Cdc42 activity is responsive to stimulation by SCF, IL3, SDF-1alpha, and fibronectin. The increased myelopoiesis and decreased erythropoiesis of the knockout mice are associated with an altered gene transcription program in ..
- Specification of the primitive myeloid precursor pool requires signaling through Alk8 in zebrafishBenjamin M Hogan
Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
Curr Biol 16:506-11. 2006..We show here that the Bmp receptor lost-a-fin/alk8 is required for rostral pu.1 expression and myelopoiesis, identifying an early genetic event that distinguishes between the induction of anterior and posterior ..
- Zebrafish granulocyte colony-stimulating factor receptor signaling promotes myelopoiesis and myeloid cell migrationClifford Liongue
School of Medicine, Deakin University, Waurn Ponds, Vic, Australia
Blood 113:2535-46. 2009..This contrasted with a posterior domain that was largely independent of this pathway. Definitive myelopoiesis was also partially dependent on a functional GCSF/GCSFR pathway...
- Differential regulation of primitive myelopoiesis in the zebrafish by Spi-1/Pu.1 and C/ebp1Fengyun Su
Division of Hematology Oncology and Cellular and Molecular Biology Program, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
Zebrafish 4:187-99. 2007..These data reveal strong functional conservation of pu.1 between zebrafish primitive myelopoiesis and mammalian definitive myelopoiesis...
- Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-γ signalingKatherine C MacNamara
Wadsworth Center, New York State Department of Health, Albany, NY 12201, USA
J Immunol 186:1032-43. 2011..Finally, using mixed bone marrow chimeric mice, we show that IFN-γ-dependent infection-induced myelopoiesis occurs via the direct effect of the cytokine on developing myeloid cells...
- Notch-dependent control of myelopoiesis is regulated by fucosylationLan Zhou
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
Blood 112:308-19. 2008..and their ligands clearly modulate T lymphopoietic decisions, evidence for their participation in modulating myelopoiesis is much less clear, and roles for posttranslational control of Notch-dependent signal transduction in ..
- Transcriptional regulation of a myeloid-lineage specific gene lysozyme C during zebrafish myelopoiesisTetsuya Kitaguchi
HMRO, Kyoto University Faculty of Medicine, Sakyo ku, Kyoto, Japan
Mech Dev 126:314-23. 2009..lines that drive enhanced green fluorescent protein (EGFP) to examine how lyz expression is regulated during myelopoiesis. We found that the 2.4kb lyz promoter is sufficient to drive myeloid-specific expression of EGFP in zebrafish...
- FoxP3+ regulatory T cells restrain splenic extramedullary myelopoiesis via suppression of hemopoietic cytokine-producing T cellsJee H Lee
Department of Comparative Pathobiology, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
J Immunol 183:6377-86. 2009Extramedullary myelopoiesis occurs in peripheral organs such as spleen and produces many types of myeloid cells with diverse functions in response to inflammation and infection...
- MicroRNAs in normal and malignant myelopoiesisElvira Pelosi
Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Leuk Res 33:1584-93. 2009..Extensive miRNA deregulation has been observed in leukemia and functional studies support a role for miRNAs in the pathogenesis of these disorders...
- Gfi1 regulates miR-21 and miR-196b to control myelopoiesisChinavenmeni S Velu
Division of Immunobiology, Cincinnati Children s Hospital Medical Center, OH 45244, USA
Blood 113:4720-8. 2009..Thus, our results not only identify microRNAs whose regulation is required during myelopoiesis, but also provide an example of synergy in microRNA biologic activity and illustrate potential mechanisms ..
- Myelopoiesis is regulated by osteocytes through Gsα-dependent signalingKeertik Fulzele
Endocrine Unit, Massachusetts General Hospital, 50 Blossom St, Thier 1101, Boston, MA 02114, USA
Blood 121:930-9. 2013..Here we report that these cells regulate hematopoiesis, constraining myelopoiesis through a Gsα-mediated mechanism that affects G-CSF production...
- Enhanced normal short-term human myelopoiesis in mice engineered to express human-specific myeloid growth factorsPaul H Miller
Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC, Canada
Blood 121:e1-4. 2013..Limiting dilution transplants further demonstrated that the early increase in human granulopoiesis in NSG-3GS mice reflects an expanded output of differentiated cells per STRC rather than an increase in STRC detection...
- Role of neutrophil elastase in bone marrow failure syndromes: molecular genetic revival of the chalone hypothesisMarshall Horwitz
Division of Medical Genetics, Department of Medicine, University of Washington School of Medicine, Seattle 98195, USA
Curr Opin Hematol 10:49-54. 2003..The authors propose that neutrophil elastase acts as an inhibitor of myelopoiesis, substantiating a chalone hypothesis proposed many years ago.
- Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesisStephanie N Zimmer
Greehey Children s Cancer Research Institute, San Antonio, TX, USA
Blood 118:69-79. 2011..Our findings reveal that a full dose of Crebbp is essential in the BM microenvironment to maintain proper hematopoiesis and to prevent excessive myeloproliferation...
- MicroRNAs: key players of normal and malignant myelopoiesisMir Farshid Alemdehy
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Curr Opin Hematol 19:261-7. 2012..The main focus of the article is the function of some evolutionary conserved microRNAs that are abundantly expressed and tightly regulated during myelopoiesis.
- Impaired myelopoiesis in mice lacking the repressors of translation initiation, 4E-BP1 and 4E-BP2Katie E Olson
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Immunology 128:e376-84. 2009..of myeloid cells in vitro, highlight the pivotal role of 4E-BP1 and 4E-BP2 in the early phases of myelopoiesis. These results represent the first in vivo evidence of the involvement of translation in the early phases of ..
- Mast cell-deficient Kit(W-sh) "Sash" mutant mice display aberrant myelopoiesis leading to the accumulation of splenocytes that act as myeloid-derived suppressor cellsAnastasija Michel
Institute for Immunology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany
J Immunol 190:5534-44. 2013..In this study, we demonstrate that Kit(W-sh) causes aberrant extramedullary myelopoiesis characterized by the expansion of immature lineage-negative cells, common myeloid progenitors, and granulocyte/..
- Overexpression of a hematopoietic transcriptional regulator EDAG induces myelopoiesis and suppresses lymphopoiesis in transgenic miceC Y Li
Department of Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Beijing, China
Leukemia 21:2277-86. 2007..The myelopoiesis was enhanced with expansion of myeloid cells in BM, increased peripheral granulocytes and extramedullary ..
- Endogenous steroids are responsible for lactoferrin-induced myelopoiesis in miceMichał Zimecki
Laboratory of Immunobiology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, PL 53 114 Wrocław, Poland
Pharmacol Rep 61:705-10. 2009..We conclude that LF-induced upregulation of endogenous steroid levels is responsible for the stimulation of myelopoiesis.
- Augmentation of myelopoiesis in a murine host bearing a T cell lymphoma following in vivo administration of proton pump inhibitor pantoprazoleNaveen Kumar Vishvakarma
School of Biotechnology, Banaras Hindu University, Varanasi 221 005, UP, India
Biochimie 93:1786-96. 2011..Thus, we studied the effect of in vivo administration of pantoprazole (PPZ), a PPI, on myelopoiesis in a murine model of a transplantable T cell lymphoma, designated as Dalton's lymphoma (DL)...
- Serglycin participates in retention of α-defensin in granules during myelopoiesisAndreas Glenthøj
The Granulocyte Research Laboratory, Department of Hematology, National University Hospital, University of Copenhagen, Copenhagen, Denmark
Blood 118:4440-8. 2011....
- The triterpenoid CDDO-Me promotes hematopoietic progenitor expansion and myelopoiesis in miceErik Ames
Department of Dermatology, University of California, Davis, Sacramento, California 95817, USA
Biol Blood Marrow Transplant 18:396-405. 2012..In the current study, we observed that CDDO-Me promoted myelopoiesis in both naive and transplanted mice...
- Angiotensin-converting enzyme is required for normal myelopoiesisChentao Lin
Department of Biomedical Science, Cedars Sinai Medical Center, Los Angeles, California, USA
FASEB J 25:1145-55. 2011..abnormalities characterized by increased bone marrow myeloblasts and myelocytes, as well as extramedullary myelopoiesis. Peritoneal macrophages from ACE-KO mice were deficient in the production of effector molecules, such as tumor ..
- Effect of aspirin administration on reversal of tumor-induced suppression of myelopoiesis in T-cell lymphoma bearing hostAnjani Kumar
School of Biotechnology, Banaras Hindu University, Varanasi 221005, U P, India
Blood Cells Mol Dis 48:238-46. 2012..studied the effect of aspirin administration in tumor-bearing hosts on bone marrow cellularity and myelopoiesis. Aspirin administration to mice bearing a transplantable T-cell lymphoma, designated as Dalton's lymphoma (DL), ..
- Biology and management of transient abnormal myelopoiesis (TAM) in children with Down syndromeAnindita Roy
Centre for Haematology, Imperial College London, London W12 0NN, UK
Semin Fetal Neonatal Med 17:196-201. 2012..leukaemia, which is clonally -related to the neonatal myeloproliferative syndrome, Transient Abnormal Myelopoiesis (TAM) unique to infants with DS...
- cIAPs and XIAP regulate myelopoiesis through cytokine production in an RIPK1- and RIPK3-dependent mannerW Wei Lynn Wong
The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia
Blood 123:2562-72. 2014..To define the role of IAPs in myelopoiesis, we generated a mouse with cIAP1, cIAP2, and XIAP deleted in the myeloid lineage...
- Tumor-induced tolerance and immune suppression by myeloid derived suppressor cellsIlaria Marigo
Department of Oncology and Surgical Sciences, Padova University, Padova, Italy, and Venetian Institute for Molecular Medicine, Padova, Italy
Immunol Rev 222:162-79. 2008..Based on observations of MDSCs, we present a time-structured and topologically consistent idea of tumor-dependent tolerance progression in tumor-bearing hosts...
- Notch signaling requires GATA-2 to inhibit myelopoiesis from embryonic stem cells and primary hemopoietic progenitorsRenee F de Pooter
Department of Immunology, University of Toronto, Sunnybrook and Women s Research Institute, 2075 Bayview Avenue, Toronto, Ontario, Canada
J Immunol 176:5267-75. 2006..that the addition of the Notch ligand Delta-like-1 (Dll-1) to an in vitro system that otherwise supports myelopoiesis, greatly reduces the myelopoietic potential of stem cells or uncommitted progenitors...
- Transcriptional regulation of myelopoiesisAlan D Friedman
Division of Pediatric Oncology, Johns Hopkins University, Baltimore, Maryland 21231, USA
Int J Hematol 75:466-72. 2002..Several mechanisms orchestrate the myeloid developmental program, including cooperative gene regulation, protein:protein interactions, regulation of factor levels, and induction of cell cycle arrest...
- ADAM10 overexpression shifts lympho- and myelopoiesis by dysregulating site 2/site 3 cleavage products of NotchDavid R Gibb
Department of Microbiology and Immunology, Virginia Commonwealth University, Massey Cancer Center, School of Medicine, Richmond, VA 23298, USA
J Immunol 186:4244-52. 2011..Collectively, these findings indicate that the differential cleavage of Notch into S2 and S3 products regulated by ADAM10 is critical to hematopoietic cell-fate determination...
- Maternal pak4 expression is required for primitive myelopoiesis in zebrafishSheran H W Law
Section on Vertebrate Development, Program on Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Development, National Institutes of Health, Bethesda, MD, USA
Mech Dev 130:181-94. 2013....
- CD44-mediated hematopoietic progenitor cell adhesion and its complex role in myelopoiesisAndres Hidalgo
Centro de Investigaciones Biologicas, Department of Immunology, Velazquez 144, 28006 Madrid, Spain
J Hematother Stem Cell Res 11:539-47. 2002..Instead, IM7.8.1 completely blocked myelopoiesis, whereas an anti-alpha 4 integrin mAb increased CFU-GM amounts...
- Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast-enhanced magnetic resonance imagingSteven T Proulx
University of Rochester, Rochester, New York 14642, USA
Arthritis Rheum 58:2019-29. 2008..In this study, MRI of murine arthritis was used to elucidate its cellular composition and vascular involvement...
- Lessons from congenital neutropenia: 50 years of progress in understanding myelopoiesisNancy Berliner
Division of Hematology, Brigham and Women s Hospital, Boston, MA, USA
Blood 111:5427-32. 2008..features and molecular pathophysiology of SCN closely parallels the progressive growth in our understanding of myelopoiesis. In this historical review, I have delineated this parallel progression in our understanding of the processes ..
- Role for hepatic and circulatory ST6Gal-1 sialyltransferase in regulating myelopoiesisMark B Jones
Departments of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
J Biol Chem 285:25009-17. 2010..We considered the possibility that myelopoiesis is responsive to the sialylation of liver-derived circulatory glycoproteins, such that reduced alpha2,6-..
- Identification of the CD33-related Siglec receptor, Siglec-5 (CD170), as a useful marker in both normal myelopoiesis and acute myeloid leukaemiasPaul Virgo
Department of Immunology and Immunogenetics, North Bristol, NHS Trust, Bristol, UK
Br J Haematol 123:420-30. 2003..All 13 acute lymphoblastic leukaemic (ALL) samples tested, including a CD33+ ALL, were Siglec-5 negative. These results support the further evaluation of Siglec-5 antibodies in the diagnosis and monitoring of AML...
- Zebrafish as a model for myelopoiesis during embryogenesisJason N Berman
Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Mass 02115, USA
Exp Hematol 33:997-1006. 2005..The conservation of genes such as scl, pu.1, c/ebpalpha, mpo, l-plastin, and lysozyme C in myelopoiesis and the corresponding expression patterns in zebrafish suggests that shared genetic pathways regulate this ..
- Treatment of human bone marrow with recombinant placenta immunoregulator ferritin results in myelopoiesis and T-cell suppression through modulation of the cytokine-chemokine networksChaya Moroz
Felsenstein Medical Research Center, Rabin Medical Center, Beilinson Campus, Sackler School of Medicine, Tel Aviv University, Petach Tikva, Israel
Exp Hematol 34:159-66. 2006..The aim of the current study was to investigate the regulatory effects of native placental ferritin (PLF), recombinant PLIF, and C48 on hematopoiesis of human bone marrow (BM)...
- Loss of gata1 but not gata2 converts erythropoiesis to myelopoiesis in zebrafish embryosJenna L Galloway
Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston, Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
Dev Cell 8:109-16. 2005..Our studies establish a transcriptional hierarchy of Gata factor dependence during hematopoiesis and demonstrate that gata1 plays an integral role in directing myelo-erythroid lineage fate decisions during embryogenesis...
- Differential effects of steroids and retinoids on bovine myelopoiesis in vitroV Van Merris
Department of Physiology, Biochemistry and Biometrics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
J Dairy Sci 87:1188-95. 2004..Hydrocortisone reduced growth of granulocyte and monocyte colonies, whereas myelopoiesis was not altered by progesterone...
- Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cellsC Gemelli
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
Cell Death Differ 13:1686-96. 2006..Altogether our data allow to conclude that MafB is a key regulator of human monocytopoiesis...
- Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alphaRudolf A Rupec
Department of Dermatology, University of Munich, Frauenlobstrasse 9 11, D 80337 Munich, Germany
Immunity 22:479-91. 2005..In summary, we show that cell-fate decisions leading to a premalignant hematopoietic disorder can be initiated by nonhematopoietic cells with inactive I kappa B alpha...
- The NOTCH pathway contributes to cell fate decision in myelopoiesisLaurence Bugeon
Imperial College London, London, SW7 2AZ, UK
Haematologica 96:1753-60. 2011Controversy persists regarding the role of Notch signaling in myelopoiesis. We have used genetic approaches, employing two Notch zebrafish mutants deadly seven (DES) and beamter (BEA) with disrupted function of notch1a and deltaC, ..
- Chronic zinc deficiency in mice disrupted T cell lymphopoiesis and erythropoiesis while B cell lymphopoiesis and myelopoiesis were maintainedLouis E King
Department of Biochemistry and Molecular Biology, Room 419, Michigan State University, East Lansing, MI 48824 1319, USA
J Am Coll Nutr 24:494-502. 2005The purpose of this study was to determine the impact of chronic zinc deficiency (ChrZD) on T and B cell lymphopoiesis, myelopoiesis and erythropoiesis in mice.
- IL-7 induces myelopoiesis and erythropoiesisFrancesca B Aiello
Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD 21702, USA
J Immunol 178:1553-63. 2007..were shown to be involved because mice deficient in both GM-CSF and IL-3 also responded to IL-7 with increased myelopoiesis. Candidate cytokines included IFN-gamma and Flt3 ligand, which were also produced in response to IL-7...
- Expression of myelopoiesis-associated microRNA in bone marrow cells of atypical chronic myeloid leukaemia and chronic myelomonocytic leukaemiaKais Hussein
Institute of Pathology, Hannover Medical School, Carl Neuberg Strasse 1, Hannover, Germany
Ann Hematol 90:307-13. 2011..b>Myelopoiesis-associated miR-10a, miR-17-5p, miR-155, miR-223 and miR-424 were analysed by real-time polymerase chain ..
- Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesisYonghui Jia
Department of Pathology, Dana Farber Harvard Cancer Center, Children s Hospital Boston and Joint Program in Transfusion Medicine, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:4739-44. 2008..Here, we demonstrate that InsP3KB is also a physiological modulator of myelopoiesis. The InsP3KB gene is expressed in all hematopoietic stem/progenitor cell populations...
- Critical roles of lysosomal acid lipase in myelopoiesisPeng Qu
Center for Immunobiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Am J Pathol 176:2394-404. 2010..These results provide evidence that LAL is an important regulator of myelopoiesis during hematopoietic development, differentiation, and homeostasis.
- Integrated analysis of microRNA and mRNA expression profiles in physiological myelopoiesis: role of hsa-mir-299-5p in CD34+ progenitor cells commitmentE Tenedini
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
Cell Death Dis 1:e28. 2010..Gain- and loss-of-function experiments revealed that hsa-miR-299-5p participates in the regulation of hematopoietic progenitor fate, modulating megakaryocytic-granulocytic versus erythroid-monocytic differentiation...
- C/EBPalpha initiates primitive myelopoiesis in pluripotent embryonic cellsYaoyao Chen
Healing Foundation Centre, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
Blood 114:40-8. 2009..Thus, C/EPBalpha is the first known single factor capable of initiating an entire myelopoiesis pathway in pluripotent cells in the embryo.
- The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domainsJ A Marteijn
Central Hematology Laboratory, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Leukemia 23:1480-9. 2009..The differential interaction of the RINGs with Ubcs strongly suggests that the ubiquitination mediated through UbcH7 as well as Ubc13 plays a major role in myelopoiesis.
- Transcriptional regulation in myelopoiesis: Hematopoietic fate choice, myeloid differentiation, and leukemogenesisAlan G Rosmarin
Department of Medicine, Brown Medical School, Providence, RI, USA
Exp Hematol 33:131-43. 2005..1 and C/EBPalpha contribute directly to development of acute myelogenous leukemia. Thus, normal myeloid development and acute leukemia are now understood to represent opposite sides of the same hematopoietic coin...
- Transient abnormal myelopoiesis complicated by tumor lysis syndromeYoshifusa Abe
Division of Neonatology, Chiba Children s Hospital, Chiba, Japan
Pediatr Int 48:489-92. 2006
- EVI1 Impairs myelopoiesis by deregulation of PU.1 functionLeopoldo Laricchia-Robbio
Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Cancer Res 69:1633-42. 2009..Here, we have examined the expression of several genes activated during terminal myelopoiesis in BM cells and identified a group of them that are altered by EVI1...
- Inverse relationship between myeloid maturation and leukotriene C4 synthase expression in normal and leukemic myelopoiesis-consistent overexpression of the enzyme in myeloid cells from patients with chronic myeloid leukemiaSusanne Tornhamre
Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Scheele Laboratory, Karolinska Institutet, S 171 77 Stockholm, Sweden
Exp Hematol 31:122-30. 2003..The aim of this study was to clarify the expression of LTC(4)S during normal and leukemic myelopoiesis and to investigate the correlation between abnormal LTC(4)S expression in CML myeloid cells and the activity of ..
- Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor outputJeffrey M Beekman
Molecular Immunology Laboratory, Department of Immunology, Wilhelmina Childrens Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands
Blood 114:3917-27. 2009..These data demonstrate that cytokine-specific functions can be transduced by unique receptor alpha-chain-associating adapter proteins...
- Genomic expression during human myelopoiesisFrancesco Ferrari
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via G, Campi 287, 41100, Modena, Italy
BMC Genomics 8:264. 2007Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where multipotent stem cells gradually limit their differentiation potential, generating different precursor cells which ..
- Critical roles for IFN-beta in lymphoid development, myelopoiesis, and tumor development: links to tumor necrosis factor alphaRaj Deonarain
Toronto General Research Institute, University Health Network, Toronto, ON, Canada MG5 2M1
Proc Natl Acad Sci U S A 100:13453-8. 2003..Taken altogether, our data suggest that, in addition to the direct growth-inhibitory effects on tumor cells, IFN-beta is required during different stages of maturation in the development of the immune system...
- STAT5-induced self-renewal and impaired myelopoiesis of human hematopoietic stem/progenitor cells involves down-modulation of C/EBPalphaAlbertus T J Wierenga
Department of Hematology, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
Blood 107:4326-33. 2006..5 (STAT5A) in human cord blood (CB)-derived stem/progenitor cells results in enhanced self-renewal and impaired myelopoiesis. The present study identifies C/EBPalpha as a critical component that is down-regulated by STAT5...
- Euphorbia tirucalli L. modulates myelopoiesis and enhances the resistance of tumour-bearing miceMarize C Valadares
Departamento de Farmacologia Hemocentro, Faculdade de Ciencias Medicas, FCM, Universidade Estadual de Campinas, UNICAMP, Campinas, SP, Brazil
Int Immunopharmacol 6:294-9. 2006..Treatment of these animals with Euphorbia tirucalli L. (ET) (125, 250 and 500 mg/kg) stimulated marrow myelopoiesis and reduced spleen colony formation, with no differences observed between the effects of the three doses...
- Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cellsSeung Woo Lee
Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
Nat Immunol 9:917-26. 2008..and its ligand 4-1BBL can control adaptive immunity, but here we show that their interaction also suppressed myelopoiesis. We found that 4-1BBL was expressed on hematopoietic stem cells, differentiating common myeloid progenitors and ..
- Genetic regulators of myelopoiesis and leukemic signaling identified by gene profiling and linear modelingAnna L Brown
Haematology and Oncology Program, Child Health Research Institute, North Adelaide, South Australia
J Leukoc Biol 80:433-47. 2006..between proliferation and self-renewal versus growth suppression and differentiation during normal and leukemic myelopoiesis are not understood...
- Deciphering developmental stages of adult myelopoiesisCornelis J Pronk
Institution for Experimental Medical Science, Immunology Section, Lund University, Lund, Sweden
Cell Cycle 7:706-13. 2008..When functionally evaluated, such early granulocyte/monocyte precursors displayed a latent lymphoid activity, which was pronounced in subsets bearing high expression of the tyrosine kinase receptor FLT3...
- Endotoxemia down-regulates bone marrow lymphopoiesis but stimulates myelopoiesis: the effect of G6PD deficiencyRachna Chandra
Department of Surgery, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103, USA
J Leukoc Biol 83:1541-50. 2008..LPS-induced down-regulation of B cell production contributes to the generalized lymphopenia and lymphocyte dysfunction observed following nonspecific immune challenges...
- Notch signaling in embryonic and adult myelopoiesisRalf Schwanbeck
Department of Biochemistry, Christian Albrechts Universitat zu Kiel, Kiel, Germany
Cells Tissues Organs 188:91-102. 2008..components and mechanisms of the Notch signaling pathway and discuss the role of Notch in embryonic and adult myelopoiesis. Finally, we will focus on mediators of Notch signaling in the hematopoietic system...
- Retinoic acid signaling in myelopoiesisKaren Drumea
Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA
Curr Opin Hematol 15:37-41. 2008..We have not attempted to summarize the related clinical literature...
- p15Ink4b: dual function in myelopoiesis and inactivation in myeloid diseaseMichael Rosu-Myles
Center for Cancer Research, National Cancer Institute, NIH, Building 37, Room 4124A, 37 Convent Drive MSC 4263, Bethesda, MD 20892 4263, USA
Blood Cells Mol Dis 40:406-9. 2008..Here we outline the mechanisms by which p15 is silenced and the functions of this CDKI in myelopoiesis as well as discuss the implications of these findings to myeloid disease.
- A novel polysaccharide of black soybean promotes myelopoiesis and reconstitutes bone marrow after 5-flurouracil- and irradiation-induced myelosuppressionHui Fen Liao
Department of Medical Research, Mackay Memorial Hospital, Taipei 251, Taiwan
Life Sci 77:400-13. 2005The aim of this study was to investigate the promotion of myelopoiesis by an active polysaccharide of black soybean (PSBS)...
- Protein kinase B (c-akt) regulates hematopoietic lineage choice decisions during myelopoiesisMiranda Buitenhuis
Molecular Immunology Lab, Department of Immunology, University Medical Center, Utrecht, The Netherlands
Blood 111:112-21. 2008..system was used to investigate the role of PI3K and its downstream effector, protein kinase B (PKB/c-akt) in myelopoiesis. PI3K activity was essential for hematopoietic progenitor survival...
- Four cases of fetal hypoechoic hepatomegaly associated with Trisomy 21 and transient abnormal myelopoiesisAkira Kikuchi
Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Prenat Diagn 27:665-9. 2007..Our objective was to determine the clinical significance of fetal hypoechoic hepatomegaly and serial change of liver sizes...
- Gangliosides of the stroma layer participate in the interferon-gamma receptor-dependent controls of myelopoiesisClaudia M B Andrade
Departamento de Bioquimica, Instituto de Ciências Básicas da Saúde ICBS, Universidade Federal do Rio Grande do Sul UFRGS, Rua Ramiro Barcelos, 2600 Anexo, CEP 90035 003 Porto Alegre, RS, Brazil
Biochim Biophys Acta 1761:1030-40. 2006Stroma-mediated myelopoiesis depends upon growth-factors and an appropriate intercellular microenvironment, whose polarity is relevant for granulocyte-macrophage colony stimulating factor (GM-CSF) mediated myeloid cell proliferation...
- Determinants of lymphoid-myeloid lineage diversificationCatherine V Laiosa
Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
Annu Rev Immunol 24:705-38. 2006....
- Effect of thermal injury on splenic myelopoiesisJohn G Noel
Research, Shriners Hospital for Children, 3229 Burnet Avenue, Cincinnati, OH 45229, USA
Shock 23:115-22. 2005..Our work clearly shows that the increased myelopoiesis observed postinjury leads to the production of mature myeloid cells...
- Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesisMark J Osborn
Department of Laboratory Medicine and Pathology, Division of Medical Technology, University of Minnesota, BSBE 6 118, 312 Church Street SE, Minneapolis, MN 55455, USA
Blood 103:843-51. 2004..Overexpression of TSLP disrupted hematopoietic homeostasis by causing imbalances in lymphopoiesis and myelopoiesis. Mice harboring a TSLP transgene had 5- to 700-fold fewer B and T precursors and no detectable pre-B lymphocyte ..
- Integrin engagement-induced inhibition of human myelopoiesis is mediated by proline-rich tyrosine kinase 2 gene productsScott J Dylla
Stem Cell Institute and Department of Medicine, University of Minnesota, Minneapolis, Minn, USA
Exp Hematol 32:365-74. 2004..Here we investigated whether PYK2 gene products mediate integrin signaling in hematopoietic stem and progenitor cells...
- Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b+ myelopoiesisBert De Klerck
Laboratory of Immunobiology, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
Arthritis Res Ther 6:R220-31. 2004..They also provide a plausible explanation for the higher susceptibility of IFN-gammaR KO mice to CIA...
- Cotransplantation of human mesenchymal stem cells enhances human myelopoiesis and megakaryocytopoiesis in NOD/SCID miceMaria Angelopoulou
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
Exp Hematol 31:413-20. 2003..Because cotransplantation of marrow-derived stromal cells has been shown to enhance engraftment of human hematopoietic stem cells, we hypothesized that cotransplantation of MSC could enhance platelet and myeloid cell development...
- Transcriptional regulators and myelopoiesis: the role of serum response factor and CREB as targets of cytokine signalingPatricia Mora-Garcia
Department of Pediatrics, Division of Hematology Oncology, Mattel Children s Hospital, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Stem Cells 21:123-30. 2003....
- A critical function for B-Raf at multiple stages of myelopoiesisTamihiro Kamata
Department of Laboratory Medicine, University of California, San Francisco, 513 Parnassus Ave, Room S 577, San Francisco, CA 94143 0100, USA
Blood 106:833-40. 2005..Together, these data suggest that B-Raf plays a cell-autonomous role in megakaryocytopoiesis and a permissive role in myeloid progenitor development...
- c-FMS chromatin structure and expression in normal and leukaemic myelopoiesisGeorge Alexander Follows
Molecular Medicine Unit, St James s University Hospital, Leeds, UK
Oncogene 24:3643-51. 2005..element located within the second intron (FIRE - fms intonic regulatory element) during normal and leukaemic myelopoiesis. Granulocytic differentiation from normal and leukaemic precursors is accompanied by loss of transcription ..
- CDP/CUT AND MYELOID DIFFERENTIATIONNancy Berliner; Fiscal Year: 2001..to further characterize the interaction of CDP and C/EBP in regulating stage specific gene expression during myelopoiesis. We will also determine the role of CDP and C/EBPa in abnormal states characterized by global failure of ..
- Molecular Mechanism of Immune Therapy for Bone Marrow FailuresPearlie K Epling-Burnette; Fiscal Year: 2013..was that an antigen, presumably a common antigen on myeloid progenitors was responsible for suppression of myelopoiesis. This was thought to be due to the direct interaction between this "putative myeloid-specific antigen" and the ..
- Inflammation and Immunosuppression in Lung CancerCong Yan; Fiscal Year: 2013..A defect in myelopoiesis with increased myeloid progenitor cells was observed in the lal-/- bone marrow...
- HoxA10 Function During Myeloid DifferentiationELIZABETH ANN EKLUND; Fiscal Year: 2011..Various hematopoietic cytokines induce HoxA10 tyrosine-phosphorylation during myelopoiesis. Since tyrosine-phosphorylation decreases HoxAIO-binding the negative cis elements in these oxidase genes, ..
- Regulation and function of nuclear envelope proteins in myelopoiesis and leukemiaPETER CHARLES WIGRAM GAINES; Fiscal Year: 2010....
- Mechanisms of PASG-Mediated Senescence in Hematopoietic Development and LeukemiaROBERT JOHN ARCECI; Fiscal Year: 2010..that the deletion variant of PASG observed in leukemia can alter epigenetic patterning in somatic cells during myelopoiesis and contribute to the development and behavior of leukemia;3) determine the frequency and expression level of ..
- NEUROFIBROMATOSIS TYPE 1 GENE REGULATES MYELOPOIESISDAVID W CLAPP; Fiscal Year: 2012..If the hypothesis is correct, we would predict that developing small molecules that inhibit Pak1 function could be useful as a molecular therapy for treatment of plexiform neurofibromas. ..
- Mucosal Mechanisms Linking Pulmonary and Gastrointestinal Inflammation/ImmunityGary B Huffnagle; Fiscal Year: 2010..and/or manifestation of immune responses in the airways, including changes in regulatory T cell responses and myelopoiesis. In this proposal, we will investigate two potential mechanisms of how the inflammatory response to a gut-..
- Molecular Mechanism of Severe Congenital NeutropeniaH Grimes; Fiscal Year: 2009..Finally, we will molecularly characterize ELA2 as a GFI1-target gene in myelopoiesis, and we will biologically test suggested genetic interactions...
- Chaperone Mechanisms in Innate ImmunityZihai Li; Fiscal Year: 2013..of both TLRs and integrins in gp96 KO murine cells;(iv) gp96 is critical for T and B lymphopoiesis but not myelopoiesis;(v) the folding of TLRs by gp96 is dependent on a substrate (TLR)-specific co-chaperone, CNPY3 (also known as ..
- Crosstalk between glioma cells &immune cells in the tumor microenvironment: TherMaria G Castro; Fiscal Year: 2013..Expansion of MDSCs can be triggered by factors produced by the tumor cells themselves, which stimulate myelopoiesis and inhibit the differentiation of mature myeloid cells...
- Role of MN1-TEL and MN1 in LeukemogenesisGerard C Grosveld; Fiscal Year: 2010..Mn1 knockout mice we will be used to determine the role of Mn1 in normal myelopoiesis. By using retroviral mutagenesis and introduction of directed mutations we will determine which genetic lesions ..
- Oral Agents to Stimulate Neutrophil ProductionSUSAN PARK PERRINE; Fiscal Year: 2010..Recently, select Hemokines were also found to stimulate myelopoiesis in cytokine-dependent human and murine myeloid cell lines, in hematopoietic progenitors cultured from normal ..
- The Role of CREB in Normal Myelopoiesis and LeukemogenesisKATHLEEN MIHO SAKAMOTO; Fiscal Year: 2013..These studies will provide new insights into how CREB regulates normal hematopoiesis and contributes to leukemogenesis. ..
- Stat3 Isoforms in Maturation and Survival of Normal and Malignant Myeloid CellsMichele S Redell; Fiscal Year: 2012..Understanding the functions of StatS isoforms in myelopoiesis and leukemogenesis will be crucial for directing future efforts at therapies targeted to signaling pathways, ..
- Biosynthesis and Function of Lactosaminyl Glycans in HematopoiesisRobert Sackstein; Fiscal Year: 2013..in hematopoiesis enabling transformative therapeutic strategies to custom-modify surface glycans to optimize myelopoiesis and thrombopoiesis, will expand glycan analytical resources, and will also fundamentally serve to mentor/..
- The influence of the ZXDC protein on myelopoiesisJoseph D Fontes; Fiscal Year: 2012..this proposal is to identify the mechanisms by which the zinc finger X-linked duplicated C (ZXDC) gene affects myelopoiesis. One ZXD family member, ZXDC, interacts with at least two key transcription factors in myeloid cell development:..
- Regulation of Granulopoiesis by Fucosylation-Dependent Notch SignalingLan Zhou; Fiscal Year: 2012..This will be the first study to define the signaling transduction pathways controlling myelopoiesis that are activated in bone marrow stem and progenitor cells after engagement of fucosylated glycoprotein, such ..
- Targeting the C/EBPalpha-Gfi-pathway in CML stem cellsBruno Calabretta; Fiscal Year: 2013..is required for regulation of the balance between differentiation and proliferation during the early stages of myelopoiesis. The importance of this function is demonstrated by the observation that C/EBP[unreadable] is genetically or ..
- Role of TET2 in normal hematopoiesis and pathogenesis of myeloid malignanciesMingjiang Xu; Fiscal Year: 2013..We, therefore, hypothesize that Tet2 acts as a tumor suppressor in myelopoiesis by regulating the behavior of HSC...
- IRF-8 as a Negative Regulator of CD11b+Gr-1+ Myeloid Cell Production and FunctionScott I Abrams; Fiscal Year: 2013..revealed an essential role for IRF-8, a member of the IRF family of transcription factors, in regulating normal myelopoiesis. The impact of IRF-8 in myelopoiesis has been clearly illuminated by alteration of the gene in mouse models...
- Effects of Microbial Exposure on MyelopoiesisHELEN SARA GOODRIDGE; Fiscal Year: 2011DESCRIPTION (provided by applicant): Myelopoiesis replenishes peripheral supplies of myeloid phagocytes in the steady-state, as well as in response to increased demand during infection...
- Defining the Mechanisms by Which Plateletes Regulate AngiogenesisElisabeth M Battinelli; Fiscal Year: 2013..In addition to her role as Director, she has a long-term expertise in myelopoiesis and has mentored a large number of young investigators...
- MicroRNAs regulating erythroid developmentCurt I Civin; Fiscal Year: 2010..Mir-155 potently reduced both myelopoiesis and erythropoiesis of normal human HSPCs, and mir-16 selectively inhibited erythropoiesis...
- The Role of 4-1BB in T Cell and APC InteractionsMichael Croft; Fiscal Year: 2010..The molecular basis of these inhibitory activities are unknown. We have found that suppression of myelopoiesis and DC differentiation is due to 4-1BBL delivering inhibitory signals to bone marrow progenitor cells...
- A TRANSCRIPTIONAL PROGRAM REGULATING MYELOPOIESISAlan Friedman; Fiscal Year: 2004..C/EBPalpha (C/EBPa) and PU.1 are key regulators of myelopoiesis. C/EBPa null mice lack granulocytes, and PU.1 null mice lack B cells, granulocytes, and monocytes...
- MYELOPOIETIC STIMULATION FOLLOWING BURN INJURYRichard Gamelli; Fiscal Year: 2007..Our group has demonstrated a significant role for bone marrow myelopoiesis (a developmental program that is responsible for the continuous production of many leukocytes) in the ..
- Carbohydrate-Dependent Adhesion in Normal and Tumor CellsMinoru Fukuda; Fiscal Year: 2012..The work centers around sulfated, fucosylated glycoconjugates in lymphocyte trafficking, tumor progression, and myelopoiesis. The work includes the role of carbohydrate-mediated signal transduction, a novel aspect in the field, through ..
- Genetic Basis of Myeloid Neoplasia--Mutagenesis ScreensA Look; Fiscal Year: 2005..a deficiency or abnormal distribution of circulating granulocytes, implicating genes important in vertebrate myelopoiesis; and (Ii) a subset of the genes discovered by this method will have human counterparts that contribute to ..
- NEUROFIBROMATOSIS TYPE 1 GENE REGULATES MYELOPOIESISDAVID CLAPP; Fiscal Year: 2001....
- METABOLIC AND MOLECULAR CONTROL OF MYELOPOIESISAlan Miller; Fiscal Year: 1991..The results of these studies will enhance our knowledge of normal and neoplastic regulation and will serve to focus future studies on the molecular genetics of altered regulation in leukemic cells...
- IMMUNOBIOLOGY OF B CELL DIFFERENTIATIONKenneth Dorshkind; Fiscal Year: 1991..The Dexter myeloid bone marrow cultures (MBMC) are optimal for myelopoiesis. No B cells are produced in this system but an early B cell precursor is maintained...
- CYTOKINE REGULATION OF HUMAN EOSINOPHIL GENESSteven Ackerman; Fiscal Year: 2006..basic protein (MBP) genes as models for defining the eosinophil developmental program in the general context of myelopoiesis. Three specific questions (aims) are proposed: (1) What are the transcription factors, their interactions and ..
- Signal Transduction by Cytokine Receptors in VivoWarner Greene; Fiscal Year: 2004..profiling and analysis of genetically modified mouse lines will establish whether specific contributions to myelopoiesis in vivo can be assigned to singular gene targets of this receptor...
- DIETARY ZINC-ITS EFFECTS ON THE IMMUNE RESPONSEPamela Fraker; Fiscal Year: 2007..We also suspect phenotypic analysis of progenitor cells in ZD mice will show they are also skewed towards myelopoiesis. 2...
- REGULATION OF HEMOPOIESIS BY STROMAL CELLSKenneth Dorshkind; Fiscal Year: 1993..In vivo studies have shown that CSFs stimulate myelopoiesis, but secondary effects on other lineages, particularly lymphopoiesis, have not been examined in detail...
- Targeted Therapy of Lyn in Myelodysplastic SyndromeSETH JOEL COREY; Fiscal Year: 2010..Therefore, we hypothesize that disordered myelopoiesis due to dysfunctional G-CSF Receptor signaling underlies some cases of MDS and that targeted therapy may ..
- Cyclin A1 as a Target in AML and Other CancersDEBRA WOLGEMUTH; Fiscal Year: 2003..The transgenic animals exhibited abnormal myelopoiesis and developed acute myeloid leukemia...
- G-CSF RECEPTOR ISOFORMS AND MYELOPOIESISScott White; Fiscal Year: 1999Granulocyte colony-stimulating factor (G-CSF), by dimerizing its receptor (G-CSFR), effects all stages of myelopoiesis. Two functionally distinct regions within the cytoplasmic domain exist...
- Hsal 2, A Novel Homeobox Gene in HematopoiesisLi Chai; Fiscal Year: 2007The long-term goal of this proposal is to define the role of Hsal2 in myelopoiesis. Hsal2 is a recently identified divergent homeobox gene that has sequence homology to the Sal homeobox gene in Drosophila...
- REGULATION OF MACROPHAGE INFLAMMATORY FUNCTIONS BY CSFRobert Moore; Fiscal Year: 1990..colony-stimulating factors (CSFs) have been considered, since their discovery, to be growth factors promoting myelopoiesis. However, there have been isolated reports suggesting that various CSFs can elicit alterations in the ..
- P-21 INDUCTION IN MYELOID DIFFERENTIATIONRichard Steinman; Fiscal Year: 1999..Specific aims of this proposal are: 1. To determine the stage specific expression of p21 in myelopoiesis and define the relationship of p21 expression to cell cycle stage and to the presence of CD11b, CD14, and CD15 ..
- ATHEROGENESIS AND THE BONE MARROW ANGIOTENSIN SYSTEMCarlos Ferrario; Fiscal Year: 2004..In Specific Aim 3 they will evaluate whether blockade of the AT1 receptor alters bone marrow myelopoiesis and expression of the bone marrow RAS in hypercholesterolemic cynomolgus monkeys treated with an AT1 receptor ..
- The Role of Cyclin A1 in Acute Myeloid LeukemiaDEBRA WOLGEMUTH; Fiscal Year: 2006..They exhibited abnormal myelopoiesis and developed acute myeloid leukemia with low penetrance and long latency...
- Adrenergic Modulation Of Myelopoiesis In Burn & SepsisStephen Jones; Fiscal Year: 2004..and experimental thermal injury and adrenergic stimulation modulates immune cell function, cytokine release and myelopoiesis under non-stressed conditions there is a lack of information on bone marrow noepinephrine (NE) release during ..
- THE ROLE OF PLASMINOGEN ACTIVATORS IN MYELOPOIESISE Wilson; Fiscal Year: 1991..The data generated during this project will yield new insights into the regulation of both normal leukemic myelopoiesis.
- The Protein Kinase C Pathway In Acute LeukemiaAMANDA REDIG; Fiscal Year: 2009..to define the expression of different PKC-isoforms during early and late stages of normal erythropoiesis and myelopoiesis, and to examine the effects of disruption of their expression or inhibition of their kinase activities on ..
- ROLE OF C/EBPalpha AND MYELOPOIESISDaniel G Tenen; Fiscal Year: 2010..The long range goals are to further our understanding of the mechanisms involved in myelopoiesis and leukemia by understanding the transcription factors which regulate myeloid development from stem cells...
- PATHOPHYSIOLOGY OF THE LACTOFERRINSPHILIP FURMANSKI; Fiscal Year: 1999..Many other diverse activities have been attributed to Lf, from feedback control of myelopoiesis to regulation of NK and macrophage function...
- MYELOID TRANSCRIPTION FACTORS AND LEUKEMIAErik Nelson; Fiscal Year: 2000..We wish to increase our understanding of normal myelopoiesis at the molecular level, and correlate this with leukemogenesis...
- DEREGULATION OF MYELOPOIESIS BY ZINC FINGER PROTEIN EVI1Archibald Perkins; Fiscal Year: 2004..We have shown that Evi-1 can blunt the accumulation of C/ebpalpha mRNA during myelopoiesis; C/ebpalpha encodes a transcriptional regulatory protein that is essential for the generation of mature ..
- Regulation of Hematopoiesis by Notch ReceptorsJames Griffin; Fiscal Year: 2007..Over the initial five years of this grant (1984-88), our aims were to identify the major cytokines affecting myelopoiesis and determine their major biological properties first in vitro, and then in vivo in human subjects...
- REGULATION OF CSF PRODUCTION BY NORMAL HUMAN CELLSJames Griffin; Fiscal Year: 1990..The information generated by this project will provide an improved understanding of the role of CSFs in myelopoiesis, the types of cells that regulate myelopoiesis, and the basic mechanisms of CSF gene regulation...
- PU1 AND SPI B AND HEMATOPOIETIC DEVELOPMENTM Simon; Fiscal Year: 2002..1 is regulated during lymphopoiesis and myelopoiesis, (iii) determine how Spi-B transcriptional activity is regulated in mature B cells, (iv) determine the extent ..
- Molecular Aspects of Myeloid Development and LeukemiaSteven Ackerman; Fiscal Year: 2005..is to bring together investigators who have expertise in complementing aspects of stem cell biology and myelopoiesis - from normal myelopoiesis to myeloid leukemias...
- MECHANISMS OF GENE REGULATION IN MYELOPOIESISJames Downing; Fiscal Year: 1993Improved understanding of the regulation of lineage-specific gene expression during myelopoiesis is needed to clarify the fundamental mechanisms controlling normal hematopoietic cell differentiation and to identify therapeutic strategies ..
- MSC as facilitators of Transplantion ToleranceAmelia Bartholomew; Fiscal Year: 2003..Further, they can provide regulatory signals that inhibit or promote lympho- and myelopoiesis, differentiation, and proliferation and secrete potent molecules, such as TGF-beta, SDF-1, IL-7, and FGF that ..
- RETINOID RESPONSIVE GENES/EARLY MYELOID DIFFERENTIATIONNoel Maun; Fiscal Year: 2001..The research goals of this proposal are to establish the role of this gene in myelopoiesis, and to dissect the mechanisms underlying its synergistic regulation by RA and IL3...
- BIOLOGY AND TRANSPLANTATION OF CLPIrving Weissman; Fiscal Year: 2000..is to place purified HSC or MPP onto clonal stromal monolayers that permit the development of B lymphocytes and myelopoiesis, either at the bulk level to measure population effects or at the single cell level, to determine whether the ..
- MECHANISM OF CSF 1 RECEPTOR GROWTH, SURVIVAL PROMOTIONAngel Lee; Fiscal Year: 2004..from the investigator's abstract) Colony-stimulating factor-1(CSF-1) and its receptor, CSF-1R, regulate myelopoiesis, bone remodeling and maturation of the reproductive system, through control of cell growth and apoptosis...
- CMYB DURING EARLY MYELOPOIESISJohn Choi; Fiscal Year: 2002....
- REGULATION OF MYELOPOIESIS: SUPPRESSOR FACTOR SYNERGISMHal Broxmeyer; Fiscal Year: 1990..propose to evaluate the separate and combined actions of these molecules in vivo in mice undergoing rebound myelopoiesis, in untreated mice, and in mice infected with the Friend Viruis Complex...
- The role of MOZ in normal and leukemic hematopoiesisCYNTHIA SNYDER; Fiscal Year: 2007..by chromosomal translocations is proposed to interfere with critical hematopoietic signaling pathways, disrupt myelopoiesis, and contribute to the development of acute myeloid leukemia...
- Maf Molecular Interactions in HematopoiesisLinda Shapiro; Fiscal Year: 2005..Understanding transcription factor function in myelopoiesis is essential for deciphering the regulation of myeloid cell differentiation...