lymphopoiesis

Summary

Summary: Formation of LYMPHOCYTES and PLASMA CELLS from the lymphoid stem cells which develop from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW. These lymphoid stem cells differentiate into T-LYMPHOCYTES; B-LYMPHOCYTES; PLASMA CELLS; or NK-cells (KILLER CELLS, NATURAL) depending on the organ or tissues (LYMPHOID TISSUE) to which they migrate.

Top Publications

  1. ncbi Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development
    Kyongrim Kwon
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 28:751-62. 2008
  2. pmc A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
    Yin C Lin
    Department of Molecular Biology, University of California, San Diego, La Jolla, California, USA
    Nat Immunol 11:635-43. 2010
  3. pmc Regulation of microRNA expression and abundance during lymphopoiesis
    Stefan Kuchen
    Genomics and Immunity, NIAMS, NIH, Bethesda, MD 20892, USA
    Immunity 32:828-39. 2010
  4. pmc An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b
    Long Li
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Science 329:89-93. 2010
  5. ncbi The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance
    Terry J Fry
    Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:6571-6. 2005
  6. pmc Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice
    Delphine Guy-Grand
    Unité de Biologie Moléculaire du Gène, INSERM U277 and Institut Pasteur, 75724 Paris Cedex 15, France
    J Exp Med 197:333-41. 2003
  7. ncbi Bcl11a is essential for normal lymphoid development
    Pentao Liu
    Mouse Cancer Genetics Program, National Cancer Institute Frederick, Maryland 21702, USA
    Nat Immunol 4:525-32. 2003
  8. pmc HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis
    Delphine Sauce
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Blood 117:5142-51. 2011
  9. ncbi An essential developmental checkpoint for production of the T cell lineage
    Tomokatsu Ikawa
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama 230 0045, Japan
    Science 329:93-6. 2010
  10. pmc A human thymic epithelial cell culture system for the promotion of lymphopoiesis from hematopoietic stem cells
    Britte C Beaudette-Zlatanova
    Department of Microbiology and Immunology Stritch School of Medicine, Loyola University Chicago, 2160 First Avenue, Maywood, IL 60153, USA
    Exp Hematol 39:570-9. 2011

Research Grants

Detail Information

Publications291 found, 100 shown here

  1. ncbi Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development
    Kyongrim Kwon
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 28:751-62. 2008
    The transcription factor E2A controls the initiation of B lymphopoiesis, which is arrested at the pre-pro-B cell stage in E2A-deficient mice...
  2. pmc A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
    Yin C Lin
    Department of Molecular Biology, University of California, San Diego, La Jolla, California, USA
    Nat Immunol 11:635-43. 2010
    ..From this analysis we constructed a global network consisting of transcriptional regulators, signaling and survival factors that we propose orchestrates B cell fate...
  3. pmc Regulation of microRNA expression and abundance during lymphopoiesis
    Stefan Kuchen
    Genomics and Immunity, NIAMS, NIH, Bethesda, MD 20892, USA
    Immunity 32:828-39. 2010
    ..We applied miRNA-, mRNA-, and ChIP-Seq to characterize the microRNome during lymphopoiesis within the context of the transcriptome and epigenome...
  4. pmc An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b
    Long Li
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Science 329:89-93. 2010
    ....
  5. ncbi The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance
    Terry J Fry
    Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:6571-6. 2005
    ..Thus, IL-7 plays critical and nonredundant roles in both T cell lymphopoiesis and in maintaining and restoring peripheral T cell homeostasis.
  6. pmc Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice
    Delphine Guy-Grand
    Unité de Biologie Moléculaire du Gène, INSERM U277 and Institut Pasteur, 75724 Paris Cedex 15, France
    J Exp Med 197:333-41. 2003
    ..In athymic mice, T lymphopoiesis occurs mainly in the mesenteric lymph node and less in the Peyer's patches...
  7. ncbi Bcl11a is essential for normal lymphoid development
    Pentao Liu
    Mouse Cancer Genetics Program, National Cancer Institute Frederick, Maryland 21702, USA
    Nat Immunol 4:525-32. 2003
    ..Here we show that Bcl11a is essential for postnatal development and normal lymphopoiesis. Bcl11a mutant embryos lack B cells and have alterations in several types of T cells...
  8. pmc HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis
    Delphine Sauce
    INSERM UMR S 945, Infections and Immunity, Avenir Group, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Blood 117:5142-51. 2011
    ..CD4(+) T-cell levels probably depends primarily on the capacity to renew depleted lymphocytes, that is, the lymphopoiesis. We performed here a comprehensive study of quantitative and qualitative attributes of CD34(+) hematopoietic ..
  9. ncbi An essential developmental checkpoint for production of the T cell lineage
    Tomokatsu Ikawa
    Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama 230 0045, Japan
    Science 329:93-6. 2010
    ..Our study thus identifies the earliest checkpoint during T cell development and shows that it is Bcl11b-dependent...
  10. pmc A human thymic epithelial cell culture system for the promotion of lymphopoiesis from hematopoietic stem cells
    Britte C Beaudette-Zlatanova
    Department of Microbiology and Immunology Stritch School of Medicine, Loyola University Chicago, 2160 First Avenue, Maywood, IL 60153, USA
    Exp Hematol 39:570-9. 2011
    ..antigen-ABC and human leukocyte antigen-DR was engineered to overexpress murine Delta-like 1 (TEC-Dl1) for the purpose of establishing a human culture system that supports T lymphopoiesis from hematopoietic progenitor cells (HPCs).
  11. pmc The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow
    Owen M Siggs
    Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
    Nat Immunol 12:434-40. 2011
    B lymphopoiesis begins in the fetal liver, switching after birth to the bone marrow, where it persists for life. The unique developmental outcomes of each phase are well documented, yet their molecular requirements are not...
  12. pmc Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development
    Stephen Malin
    Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria
    Nat Immunol 11:171-9. 2010
    STAT5 and interleukin 7 (IL-7) signaling are thought to control B lymphopoiesis by regulating the expression of key transcription factors and by activating variable (V(H)) gene segments at the immunoglobulin heavy-chain (Igh) locus...
  13. ncbi Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis
    Ute Koch
    Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Federale de Lausanne EPFL, Epalinges, Switzerland
    Blood 111:160-4. 2008
    ..of beta-catenin (which is considered to be essential for Wnt signaling) has no effect on hematopoiesis or lymphopoiesis. Here, we address whether this discrepancy can be explained by a redundant and compensatory function of gamma-..
  14. pmc Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis
    Joan Yuan
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, MD 20892, USA
    Science 335:1195-200. 2012
    ..bone marrow, which endows them with the ability to mediate multilineage reconstitution that resembles fetal lymphopoiesis, including increased development of B-1a, marginal zone B, gamma/delta (γδ) T cells, and natural killer T (..
  15. pmc Beta-catenin is dispensable for hematopoiesis and lymphopoiesis
    Monica Cobas
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
    J Exp Med 199:221-9. 2004
    ..In contrast to earlier reports, these data exclude an essential role for beta-catenin during hematopoiesis and lymphopoiesis.
  16. pmc Aging induced decline in T-lymphopoiesis is primarily dependent on status of progenitor niches in the bone marrow and thymus
    Liguang Sun
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Aging (Albany NY) 4:606-19. 2012
    ..organismal age, but aging in niche cells occurred much earlier than in LPCs by an observation in thymic T-lymphopoiesis. Therefore, the aging induced decline in competence to generate T cells is primarily dependent on status of ..
  17. pmc A critical role for Rictor in T lymphopoiesis
    Fei Tang
    Division of Immunotherapy, Department of Surgery, University of Michigan Medical School and Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    J Immunol 189:1850-7. 2012
    Apart from a critical role for Notch and pre-TCR, the signaling pathway required for T lymphopoiesis is largely unknown...
  18. ncbi Development of human lymphoid cells
    Bianca Blom
    Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands
    Annu Rev Immunol 24:287-320. 2006
    ....
  19. pmc Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis
    Christos Gekas
    Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Blood 113:3461-71. 2009
    ..In summary, this work identifies Mef2C as an integral member of hematopoietic transcription factors with distinct upstream regulatory mechanisms and functional requirements in megakaryocyte and B-lymphoid lineages...
  20. ncbi The ageing immune system: is it ever too old to become young again?
    Kenneth Dorshkind
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095, USA
    Nat Rev Immunol 9:57-62. 2009
    ..But is the immune system ever too old to become young again? We review here the promise of various approaches to rejuvenate the function of the immune system in the rapidly growing ageing population...
  21. pmc Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging
    Lisa M Guerrettaz
    Department of Immunology, University of Colorado, Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 105:11898-902. 2008
    ..We tested the hypothesis that aging-associated repertoire changes can be attributed directly to decreased B lymphopoiesis. Using an Ig transgenic model to report changes in the B-cell repertoire, we show that the reduced B-cell ..
  22. ncbi Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells
    Geneve Awong
    Department of Immunology, University of Toronto, Toronto, ON, Canada
    Blood 114:972-82. 2009
    ..Taken together, the identification of T-progenitor subsets readily generated in vitro may offer important avenues to improve cellular-based immune-reconstitution approaches...
  23. ncbi Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13
    Heather J Melichar
    Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    Science 315:230-3. 2007
    ..Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes...
  24. ncbi Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis
    Thorsten Decker
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 30:508-20. 2009
    ..These experiments demonstrate a stepwise activation of Pax5 in early lymphopoiesis and provide mechanistic insights into the process of B cell commitment.
  25. pmc gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis
    Matthew Staron
    Department of Immunology, University of Connecticut School of Medicine, Farmington, CT 06030 1601, USA
    Blood 115:2380-90. 2010
    Integrins contribute to lymphopoiesis, whereas Toll-like receptors (TLRs) facilitate the myeloid replenishment during inflammation. The combined role of TLRs and integrin on hematopoiesis remains unclear...
  26. pmc IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expression
    Kazu Kikuchi
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 181:383-92. 2008
    ..However, it was not clear when IL-7 stimulation is necessary in hemato-/lymphopoiesis in adult mice...
  27. pmc Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion
    Peng Li
    Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Science 329:85-9. 2010
    ..Therefore, ITNKs may represent a new cell source for cell-based therapies...
  28. pmc Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible
    Hiromi Tagoh
    Molecular Medicine Unit, St James s University Hospital, University of Leeds, Leeds LS9 7TF, UK
    EMBO J 23:4275-85. 2004
    ..To examine the role of chromatin structure in this process we studied epigenetic silencing of c-fms during B-lymphopoiesis. c-fms chromatin in stem cells and multipotent progenitors is in the active conformation and bound by ..
  29. ncbi Receptor editing in positive and negative selection of B lymphopoiesis
    Efrat Edry
    Department of Immunology, Faculty of Medicine, Technion, Israel
    J Immunol 173:4265-71. 2004
    In B lymphopoiesis, Ag receptor expression and signaling are critical to determine developmental progression, survival, and activation...
  30. pmc A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity
    Heon Park
    Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
    J Exp Med 205:2899-913. 2008
    ....
  31. pmc Identification of a T lineage-committed progenitor in adult blood
    Andreas Krueger
    Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Immunity 26:105-16. 2007
    ..Thus, CTP represent T lineage-committed T cell precursors linking extrathymic with intrathymic lymphopoiesis in adult mice.
  32. pmc Asynchronous RAG-1 expression during B lymphopoiesis
    Robert S Welner
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Immunol 183:7768-77. 2009
    ..These findings indicate that essential events in B lymphopoiesis are not tightly synchronized...
  33. pmc Alphabeta versus gammadelta lineage choice at the first TCR-controlled checkpoint
    Taras Kreslavsky
    Laboratory of Lymphocyte Biology, Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Curr Opin Immunol 22:185-92. 2010
    ..Recent experiments support the former view...
  34. ncbi Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell pool
    Ewa Sitnicka
    Department of Stem Cell Biology, Institute of Laboratory Medicine, University Hospital of Lund, BMC, B12, Klinikgatan 26, 221 84 Lund, Sweden
    Immunity 17:463-72. 2002
    ..Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC...
  35. ncbi Epigenetic events during B lymphocyte development
    Maribel Parra
    Cellular Differentiation Group, Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, Barcelona, Spain
    Epigenetics 4:462-8. 2009
    ..field have made significant advances towards understanding the contribution of transcription factors during B lymphopoiesis.They have established the existence of transcription factor networks that are essential for the proper ..
  36. ncbi B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging
    Zohar Keren
    Department of Immunology, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    Blood 117:3104-12. 2011
    Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation of long-lived B cells in the periphery. These changes decrease the body's ability to mount protective antibody responses...
  37. ncbi HAX1 deficiency: impact on lymphopoiesis and B-cell development
    Doris Peckl-Schmid
    Department of Molecular Biology, University of Salzburg, Salzburg, Austria
    Eur J Immunol 40:3161-72. 2010
    ..Hax1(-/-) B cells show a significantly reduced expression of CXCR4, which might have an influence on the observed defects in B-cell development...
  38. pmc Enhancement of hematopoiesis and lymphopoiesis in diet-induced obese mice
    Mark D Trottier
    Biochemistry and Molecular Biology Department, Michigan State University, East Lansing, MI 48824, USA
    Proc Natl Acad Sci U S A 109:7622-9. 2012
    ..Leptin, which promotes lymphopoiesis and myelopoiesis, reached 100 ng/mL in sera from HFD mice...
  39. ncbi Human induced pluripotent stem cells are capable of B-cell lymphopoiesis
    Lee Carpenter
    Stem Cell Research Laboratory, National Health Service Blood and Transplant, John Radcliffe Hospital, Oxford, UK
    Blood 117:4008-11. 2011
    ..We therefore have been able to demonstrate, for the first time, that human iPS cells are able to undergo hematopoiesis that contributes to the B-cell lymphoid lineage...
  40. pmc The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesis
    Roger Revilla-i-Domingo
    Department of Immunology, Research Institute of Molecular Pathology, Vienna Biocenter, Austria
    EMBO J 31:3130-46. 2012
    ..Hence, Pax5 controls B-cell identity and function by regulating distinct target genes in early and late B lymphopoiesis.
  41. pmc Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance
    Kirsteen J Campbell
    Molecular Genetics of CancerDivision, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia
    Blood 116:3197-207. 2010
    ..Myelopoiesis was relatively normal, but lymphopoiesis was clearly perturbed, with excess mature B and T cells accumulating...
  42. ncbi In interleukin-7-transgenic mice, increasing B lymphopoiesis increases follicular but not marginal zone B cell numbers
    Rhodri Ceredig
    Unité 548 INSERM, DRDC, Commissariat a l Energie Atomique Grenoble, Grenoble, France
    Eur J Immunol 33:2567-76. 2003
    ..In situations of decreased bone marrow B lymphopoiesis, the proportion of spleen marginal zone B cells increases, but the consequence of increasing B lymphopoiesis ..
  43. ncbi Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis
    Cecile Huin-Schohn
    Department of Development and Immunogenetics, Lorraine University, Vandoeuvre les Nancy, France
    FASEB J 27:333-41. 2013
    ..Taken together, and given that the larvae were not immunized, these data suggest a modification of lymphopoiesis when gravity changes occur during ontogeny.
  44. pmc The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors
    Fabian Zohren
    Department of Haematology, Oncology and Clinical Immunology, Heinrich Heine University, Dusseldorf, Germany
    Nat Immunol 13:761-9. 2012
    ..We identified Gfi1 as a critical transcriptional target of Lyl-1-mediated lymphopoiesis of T cells...
  45. ncbi Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus
    Howard T Petrie
    Laboratory of Developmental Immunology, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    Nat Rev Immunol 3:859-66. 2003
  46. ncbi FOXN1 mutation abrogates prenatal T-cell development in humans
    I Vigliano
    Department of Pediatrics, Federico II University, Via Pansini, 5, Naples 80131, Italy
    J Med Genet 48:413-6. 2011
    ....
  47. pmc Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis
    Jianjun Shi
    Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL, USA
    Blood 118:2511-9. 2011
    Notch1 signaling is absolutely essential for steady-state thymic lymphopoiesis, but the role of other Notch receptors, and their potential overlap with the function of Notch1, remains unclear...
  48. pmc Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells
    Erin C Zook
    Cell Biology, Neurobiology and Anatomy Graduate Program, Stritch Shool of Medicine, Loyola University Chicago, Maywood, IL, USA
    Blood 118:5723-31. 2011
    ..Our data indicate that manipulation of Foxn1 expression in the thymus ameliorates thymopoiesis in aged mice and offer a strategy to combat the age-associated decline in naive T-cell production and CD4 naive/memory ratios in the elderly...
  49. pmc Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF
    Takahiro Maeda
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Science 316:860-6. 2007
    ..We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage...
  50. pmc Critical roles for c-Myb in lymphoid priming and early B-cell development
    Kylie T Greig
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Blood 115:2796-805. 2010
    ..c-Myb-deficient mice display reduced numbers of B cells; however, it is unknown what role c-Myb plays in B lymphopoiesis because no critical target genes have been identified in the B-cell lineage...
  51. pmc Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia
    Robert A J Signer
    Department of Pathology and Laboratory Medicine and Hematopoietic Malignancies Program, Jonsson Comprehensive Cancer Center, Los Angels, CA 90095, USA
    Blood 110:1831-9. 2007
    Reduced lymphopoiesis during aging contributes to declines in immunity, but little consideration has been given to its effect on the development of hematologic disease...
  52. ncbi Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor protein
    Satoshi Takaki
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan
    J Immunol 170:703-10. 2003
    ..Our results illuminate the novel negative regulatory mechanism mediated by the Lnk adaptor protein in controlling lymphocyte production and function...
  53. ncbi Effects of aging on the common lymphoid progenitor to pro-B cell transition
    Hyeyoung Min
    Department of Pathology and Laboratory Medicine and Hemopoietic Malignancies Program, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 176:1007-12. 2006
    ..These age-related changes in early B lymphopoiesis do not result from a general defect in HSC or the bone marrow microenvironment that impairs development in all ..
  54. ncbi Lineage relationship analysis of RORgammat+ innate lymphoid cells
    Shinichiro Sawa
    Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France
    Science 330:665-9. 2010
    ..Contrary to RORγt(+) T cells, however, RORγt(+) ILCs develop in the absence of microbiota. Our study indicates that RORγt(+) ILCs evolve to preempt intestinal colonization by microbial symbionts...
  55. pmc Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis
    Takafumi Yokota
    Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Immunol 181:6061-72. 2008
    It has long been known that lymphopoiesis is transiently suppressed during pregnancy, which can be experimentally simulated by estrogen treatment...
  56. pmc B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitors
    Lisa Borghesi
    Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester 01655, USA
    J Exp Med 199:491-502. 2004
    ..As activity of the Erag enhancer is restricted to the B cell lineage, this provides the first molecular evidence for establishment of a lineage-specific transcription program in multipotent progenitors...
  57. pmc Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineage
    Tatiana Corbeaux
    Max Planck Institute of Immunobiology, Freiburg D 79108, Germany
    Proc Natl Acad Sci U S A 107:16613-8. 2010
    ..Our findings therefore support the notion that Foxn1 is the essential transcription factor regulating the differentiation of TECs and that its expression marks the major functional lineage of TECs in embryonic and adult thymic tissue...
  58. ncbi Frizzled 9 knock-out mice have abnormal B-cell development
    Erik A Ranheim
    Departments of Pathology and Genetics, Stanford University School of Medicine, Stanford, CA, USA
    Blood 105:2487-94. 2005
    ..Mature B cells are present in normal numbers in lymph node and spleen. These findings suggest a role for Fzd9 signaling in lymphoid development, particularly at points where B cells undergo self-renewal prior to further differentiation...
  59. pmc The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis
    Ping Lu
    Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Exp Med 207:1359-67. 2010
    A recessive mutation named Justy was found that abolishes B lymphopoiesis but does not impair other major aspects of hematopoiesis...
  60. pmc Awakening lineage potential by Ikaros-mediated transcriptional priming
    Toshimi Yoshida
    Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Curr Opin Immunol 22:154-60. 2010
    ..Loss of Ikaros removes the lymphoid leg of the immune system and may confer aberrant self-renewing properties to myeloid progenitors...
  61. ncbi Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c
    Sandra Stehling-Sun
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nat Immunol 10:289-96. 2009
    ..1 during lymphopoiesis. Thus, Mef2c is a crucial component of the transcriptional network that regulates cell fate 'choice' in ..
  62. ncbi Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells
    Jiang Zhu
    Department of Medicine, Division of Hematology Oncology, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA
    Blood 109:3706-12. 2007
    Early B lymphopoiesis in mammals is induced within the bone marrow (BM) microenvironment, but which cells constitute this niche is not known...
  63. ncbi Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional mice
    Zhangfa Song
    Institute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, Germany
    Blood 115:1481-9. 2010
    There is growing evidence that telomere dysfunction can contribute to human aging. Telomere dysfunction limits lymphopoiesis in aging telomerase knockout (mTerc(-/-)) mice primarily by the induction of stem cell-extrinsic alterations...
  64. ncbi Activation of thymic regeneration in mice and humans following androgen blockade
    Jayne S Sutherland
    Department of Immunology, Monash University Medical School, Prahran, Victoria, Australia
    J Immunol 175:2741-53. 2005
    ..Collectively these studies represent a fundamentally new approach to treating immunodeficiency states in humans...
  65. pmc Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction
    Michael L Chen
    Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Blood 114:4045-53. 2009
    ..macrocytic anemia with abnormal erythroid maturation and megaloblastic changes, as well as profound defects in lymphopoiesis. Mice die of severe fatal anemia at 15 months of age...
  66. ncbi Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment
    Sofie Singbrant
    St Vincent s Institute of Medical Research and Department of Medicine at St Vincent s Hospital, University of Melbourne, Fitzroy, Victoria, Australia
    Blood 117:5631-42. 2011
    ..Surprisingly, we also found that Epo induced a rapid 26% loss of the trabecular bone volume and impaired B-lymphopoiesis within the bone marrow microenvironment...
  67. ncbi Regulation of B-cell fate by antigen-receptor signals
    Hiroaki Niiro
    Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
    Nat Rev Immunol 2:945-56. 2002
    ..Recent progress in unravelling the molecular mechanisms of the BCR signalling pathways has helped to clarify how BCR signals regulate the proliferation, survival and apoptosis of developing B cells...
  68. ncbi B lymphopoiesis is active throughout human life, but there are developmental age-related changes
    Maria Isabel D Rossi
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Blood 101:576-84. 2003
    This study addressed several questions concerning age-related changes in human B lymphopoiesis. The relative abundance of pro-B, pre-B, immature, naive, and mature B cells among the CD19(+) lymphocyte fraction of human bone marrow was ..
  69. pmc B-cell development fails in the absence of the Pbx1 proto-oncogene
    Mrinmoy Sanyal
    Department of Pathology, Stanford University, School of Medicine, Stanford, CA 94305, USA
    Blood 109:4191-9. 2007
    ..from Pbx1-deficient fetal liver cells was also severely compromised, but not erased, since transient B lymphopoiesis was detected in Rag-deficient recipients...
  70. pmc Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
    Annette Deichmann
    Institute for Molecular Medicine and Cell Research and Department of Internal Medicine I, German Cancer Research Center, University of Freiburg, Freiburg, Germany
    J Clin Invest 117:2225-32. 2007
    ..Beyond the observed cases of insertional mutagenesis in 3 patients, these data help to elucidate the relationship between vector insertion and long-term in vivo selection of transduced cells in human patients with SCID-X1...
  71. pmc Sustained activation of cell adhesion is a differentially regulated process in B lymphopoiesis
    Aleksandra M Glodek
    Joint Program in Transfusion Medicine, Harvard Medical School, Children s Hospital Boston, Boston, MA 02115, USA
    J Exp Med 197:461-73. 2003
    ..These results provide a developmental cell stage-specific mechanism by which chemokines orchestrate hematopoiesis through sustained rather than transient activation of adhesion and cell survival pathways...
  72. ncbi Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity
    Robert Mansson
    Department for Clinical and Experimental Sciences, Linkoping University, Linkoping, Sweden
    Blood 115:2601-9. 2010
    ..These data suggest that the classic common lymphoid progenitor compartment composes a mixture of cells with relatively restricted lineage potentials, thus opening new possibilities to investigate early hematopoiesis...
  73. ncbi Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling
    Marcus R Clark
    Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Illinois 60637, USA
    Nat Rev Immunol 14:69-80. 2014
    ....
  74. pmc Insights on FoxN1 biological significance and usages of the "nude" mouse in studies of T-lymphopoiesis
    Zhijie Zhang
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
    Int J Biol Sci 8:1156-67. 2012
    ..We also raise questions and propose further consideration of FoxN1 functions and utilizing this mouse model for immune function studies...
  75. pmc Radical reversal of vasoactive intestinal peptide (VIP) receptors during early lymphopoiesis
    Emilie E Vomhof-DeKrey
    Department of Chemistry and Biochemistry, North Dakota State University, Fargo, ND 58102, USA
    Peptides 32:2058-66. 2011
    ..that a high VPAC1:VPAC2 ratio in the earliest thymocyte progenitors (ETP cells) would be reversed during early lymphopoiesis as observed in activated, peripheral Th(2) cells, as the thymus is rich in Th(2) cytokines...
  76. ncbi Strength of signal: a fundamental mechanism for cell fate specification
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
    Immunol Rev 209:170-5. 2006
    ..In this review, we compare the alphabeta/gammadelta fate decision with other cell fate decisions that occur outside of the lymphoid system to attain a better picture of the quantitative signaling mechanism for cell fate specification...
  77. ncbi Overexpression of a hematopoietic transcriptional regulator EDAG induces myelopoiesis and suppresses lymphopoiesis in transgenic mice
    C Y Li
    Department of Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Beijing, China
    Leukemia 21:2277-86. 2007
    ..In contrast to myeloid cells, the lymphoid commitment was severely impaired with the B lymphopoiesis blocked at the transition from pro/pre-B I to pre-B II stage in BM and T thymocytes development blocked at the ..
  78. pmc Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitors
    Christopher L Cooper
    Department of Molecular Biology and Genetics and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 119:5438-48. 2012
    The role of hedgehog (Hh) signaling in B lymphopoiesis has remained unclear...
  79. ncbi A checkpoint in B-lymphopoiesis related to Notch resistance
    Kazuki Okuyama
    Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan
    Biochem Biophys Res Commun 417:141-6. 2012
    While murine B- and T-lymphopoiesis require overlapping molecules, they occur in separate organs: the bone marrow (BM) and the thymus, respectively...
  80. ncbi A genetic locus controlling aging-sensitive regression of B lymphopoiesis in an autoimmune-prone MRL/lpr strain of mice
    K Nakatani
    First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Scand J Immunol 66:654-61. 2007
    ..Fas(lpr) (MRL/lpr) strain of mice. This abnormality was characterized by the regression of B lymphopoiesis in the bone marrow of this strain...
  81. pmc In vitro requirement for periostin in B lymphopoiesis
    Basile T Siewe
    Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 S First Ave, Maywood, IL 60153, USA
    Blood 117:3770-9. 2011
    B lymphopoiesis arrests in rabbits by 4 months of age...
  82. pmc Selective role of calcineurin in haematopoiesis and lymphopoiesis
    Elena M Gallo
    Multidisciplinary Program in Immunology, Stanford University, Stanford, California, USA
    EMBO Rep 9:1141-8. 2008
    ..The requirement for calcineurin/NFAT in the development of the adaptive but not of the innate immune system is consistent with the idea that the evolutionary appearance of this pathway was involved in the emergence of vertebrates...
  83. ncbi Role of thymic organ structure and stromal composition in steady-state postnatal T-cell production
    Howard T Petrie
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Immunol Rev 189:8-19. 2002
    ....
  84. pmc Oestrogen receptor specificity in oestradiol-mediated effects on B lymphopoiesis and immunoglobulin production in male mice
    M C Erlandsson
    Department of Rheumatology and Inflammation Research, Department of Internal Medicine, Goteborg University, Guldhedsgatan 10A, S 413 46 Goteborg, Sweden
    Immunology 108:346-51. 2003
    Oestrogen treatment down-regulates B lymphopoiesis in the bone marrow of mice. Meanwhile it up-regulates immunoglobulin production...
  85. ncbi Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesis
    Feng Guo
    Research Group Immunology, Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
    Blood 112:551-9. 2008
    ..progenitors restored early B-cell development in p100(-/-) bone marrow, suggesting that impaired early B lymphopoiesis in mice lacking the p100 inhibitor may be due to down-regulation of Pax5 expression...
  86. ncbi [Effects of electroacupuncture on T-lymphocytes, spleen index, thymus index and lymphopoiesis levels in strenuous exercise-induced stress rats]
    Yong Mei Lu
    College of Nursing, Guangzhou University of Chinese Medicine, Guangzhoug 510405, China
    Zhen Ci Yan Jiu 37:136-9. 2012
    To observe the effect of electroacupuncture (EA) on levels of T-lymphocytes, spleen index, thymus index and lymphopoiesis in strenuous exercise-induced immunosuppression rats, so as to study its mechanisms underlying improving immune ..
  87. ncbi Wnt signaling in lymphopoiesis
    A Timm
    Gene Center and Institute of Biochemistry, University of Munich, Germany
    Curr Top Microbiol Immunol 290:225-52. 2005
    ..and gain-of-function experiments in the mouse have provided insight into the role of this signaling pathway in lymphopoiesis. The self-renewal and maintenance of hematopoietic stem cells is regulated by Wnt signals...
  88. ncbi Chronic zinc deficiency in mice disrupted T cell lymphopoiesis and erythropoiesis while B cell lymphopoiesis and myelopoiesis were maintained
    Louis E King
    Department of Biochemistry and Molecular Biology, Room 419, Michigan State University, East Lansing, MI 48824 1319, USA
    J Am Coll Nutr 24:494-502. 2005
    The purpose of this study was to determine the impact of chronic zinc deficiency (ChrZD) on T and B cell lymphopoiesis, myelopoiesis and erythropoiesis in mice.
  89. ncbi Withdrawal of sex steroids reverses age- and chemotherapy-related defects in bone marrow lymphopoiesis
    Jarrod A Dudakov
    Immune Regeneration Laboratory, Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Australia
    J Immunol 182:6247-60. 2009
    ..T cell production, there are also significant declines in B cell development and the progenitors that support lymphopoiesis. These collectively lead to a reduced peripheral immune repertoire, increase in opportunistic infections, and ..
  90. ncbi IL-7: a key regulator of B lymphopoiesis
    Craig D Milne
    Ontario Cancer Institute, University Health Network, Department of Immunology, University of Toronto, Toronto, Ontario, Canada
    Semin Immunol 18:20-30. 2006
    ..Because of its central role in adult murine B lymphopoiesis, IL-7 is frequently used to generate B cell progenitors in vitro...
  91. ncbi Hoxb3 deficiency impairs B lymphopoiesis in mouse bone marrow
    King Hung Ko
    Department of Pathology and Center of Infection and Immunology, The University of Hong Kong, Hong Kong, China
    Exp Hematol 35:465-75. 2007
    ..Hox genes are involved in hematopoietic lineage commitment and differentiation. In this study, we investigated the roles of Hoxb3 in hematopoiesis by examining the phenotypes of a Hoxb3 knockout mutant mouse line...
  92. pmc Premature replacement of mu with alpha immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturation
    Sophie Duchez
    Laboratoire d Immunologie, Universite de Limoges, Centre National de la Recherche Scientifique Unité Mixte 6101, F 87025 Limoges, France
    Proc Natl Acad Sci U S A 107:3064-9. 2010
    ..Our data indicate that the IgM BCR is more efficient in driving early B cell education and in mucosal site targeting, whereas the IgA BCR appears particularly suited to promoting activation and differentiation of effector plasma cells...
  93. pmc B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient mice
    Cornelia Brunner
    Department of Physiological Chemistry, University of Ulm, D 89081 Ulm, Germany
    J Exp Med 197:1205-11. 2003
    ..Virtually no functional MZ B cells were detected in these mice. In contrast, mice deficient for Bcl2 show a relative increase in MZ B cell numbers, indicating a previously undetected function of Bcl2 for this B cell compartment...
  94. pmc T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosis
    Viki Bockstal
    Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts, United States of America
    PLoS Pathog 7:e1002089. 2011
    ..In the spleen, T. brucei induces extramedullary B lymphopoiesis as evidenced by significant increases in HSC-LMPP, CLP, pre-pro-B, pro-B and pre-B cell populations...
  95. ncbi B lymphopoiesis is characterized by pre-B cell marker gene expression in fetal cattle and declines in adults
    Anna Ekman
    Department of Veterinary Biosciences, University of Helsinki, P O Box 66, 00014 Helsinki, Finland
    Dev Comp Immunol 37:39-49. 2012
    ..lack of B-lymphoid differentiation in adult bone marrow - OP9 stromal cell co-culture, suggest a decline of B lymphopoiesis in adult cattle...
  96. pmc Wnt expression and canonical Wnt signaling in human bone marrow B lymphopoiesis
    Guri Døsen
    Department of Immunology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Medical Faculty, University of Oslo, Norway
    BMC Immunol 7:13. 2006
    The early B lymphopoiesis in mammals is regulated through close interactions with stromal cells and components of the intracellular matrix in the bone marrow (BM) microenvironment...
  97. pmc Distinct changes in adult lymphopoiesis in Rag2-/- mice fully reconstituted by alpha4-deficient adult bone marrow cells
    Ena R Banerjee
    Department of Medicine, Division of Hematology, University of Washington, Seattle, WA 98195 7710, USA
    Exp Hematol 36:1004-13. 2008
    ....
  98. ncbi At the crossroads: diverse roles of early thymocyte transcriptional regulators
    Michele K Anderson
    Sunnybrook and Women s College Health Sciences Center, Division of Molecular and Cell Biology, University of Toronto, Department of Immunology, Toronto, ON, Canada
    Immunol Rev 209:191-211. 2006
    ....
  99. ncbi Spontaneous class switch recombination in B cell lymphopoiesis generates aberrant switch junctions and is increased after VDJ rearrangement
    Efrat Edry
    Department of Immunology, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Immunol 179:6555-60. 2007
    ..Recently, we have shown that CSR spontaneously occur in B lymphopoiesis. However, the mechanism and regulation of it have not been defined...
  100. ncbi Linking age-related defects in B lymphopoiesis to the aging of hematopoietic stem cells
    Juli P Miller
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 269 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
    Semin Immunol 17:321-9. 2005
    ....
  101. ncbi BMP-6 inhibits human bone marrow B lymphopoiesis--upregulation of Id1 and Id3
    Christian Kersten
    Department of Immunology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
    Exp Hematol 34:72-81. 2006
    ..Bone morphogenetic proteins (BMPs) are multifunctional cytokines previously found to regulate hematopoietic stem cells. In the present study, we have explored the role of BMP-6 in human B progenitor cells...

Research Grants66

  1. Pluripotent stem cell-derived HSCs: improvements and molecular mechanisms
    Patrick Cahan; Fiscal Year: 2013
    ..Aim 2 will assess the contribution of Notch signaling to deficient lymphopoiesis in Hoxb4-induced PSC-HSCs. The five-year training program has been designed to establish Dr...
  2. B Cell Development in Aging
    John C Cambier; Fiscal Year: 2010
    ..Thus, decreased B lymphopoiesis may be causal in the aging- associated decline in humoral immunity to newly encountered pathogens...
  3. Live cell imaging of IgH and c-Myc gene loci and the role of nuclear organization
    Mark T Groudine; Fiscal Year: 2010
    ..Further, the distance between the IgH and c-Myc loci will be measured through lymphopoiesis and used to determine if the distance between the two loci prior to B cell stimulation influences the ..
  4. Role of the developmental regulator Gon4-like in B lymphopoiesis
    JOHN D COLGAN; Fiscal Year: 2011
    ..Further, the knowledge gained will provide new insights regarding the fundamental processes that contribute to immune dysfunction or the development of lymphoid cancers. ..
  5. Environmental PPAR Agonists Accelerate Aging of Bone and Impair Lymphopoiesis
    AMELIA RACHEL HAAS BAKER; Fiscal Year: 2013
    ..1-500 nM). The bone marrow is a multifunctional organ that supports bone formation, as well as lymphopoiesis, and both functions are compromised during aging...
  6. Somatic Hypermutation in SLE
    Lawrence J Wysocki; Fiscal Year: 2013
    ..genes and because of extensive somatic diversity generated by processes that assemble V region genes during B lymphopoiesis in the bone marrow and that mutate them in the periphery during immune responses...
  7. Role of the developmental regulator Gon4-like in B lymphopoiesis
    JOHN D COLGAN; Fiscal Year: 2013
    ..Such knowledge will provide novel insights regarding the relationships between impairment of B cell development and the appearance of immunodeficiencies or B cell progenitor-derived lymphoid cancers. ..
  8. Pax5:Hematopoietic Transcription Factor Involved in ALL
    HAROLD PHILLIP KOEFFLER; Fiscal Year: 2013
    ..First, we will determine if expression of PAX5 fusion proteins disrupts normal steady-state lymphopoiesis or hematopoiesis by impairing differentiation, promoting survival and/or proliferation of specific ..
  9. Regulation of cyclin D3 in B lymphocyte development
    Marcus R Clark; Fiscal Year: 2013
    ..Early in B lymphopoiesis, Igm assembles with surrogate light chain and Iga/Igb to form a pre-BCR that first expands pre-B cell ..
  10. B-Cell Tolerance Mechanisms in Human SLE
    JENNIFER HOWITT ANOLIK; Fiscal Year: 2013
    ..that a key dysregulated signal is interferon (IFN), with local production in the BM inhibiting BM B cell lymphopoiesis. On the other hand, we have found that a subset of SLE patients treated with BCDT experience restoration of B ..
  11. HOW ENVIRONMENTAL CHEMICALS IMPAIR IMMUNITY
    David Sherr; Fiscal Year: 2009
    ..We demonstrated that PAH suppress B lymphopoiesis by inducing pro-B and pre-B cell apoptosis mediated indirectly through stromal cells constituting the ..
  12. Maintaining B cell immunity with aged B lymphocytes
    Katherine L Knight; Fiscal Year: 2013
    ..Rabbits provide a useful model for studying the decline in B lymphopoiesis because it declines precipitously a few weeks after birth, and by 2 to 4 months of age, little or no B ..
  13. Molecular basis for age-related thymic involution and rejuvenation
    Dong Ming Su; Fiscal Year: 2013
    ..We will test the hypothesis that Foxn1-controlled TECs mediate critical changes of thymic aging, including T-lymphopoiesis and prevention of autoimmunity. To test this hypothesis, we propose four specific aims...
  14. Lymphoid signals for stromal growth and organization in the thymus.
    Howard T Petrie; Fiscal Year: 2012
    ..The thymus is the primary site of de novo T lymphopoiesis. Microenvironmental conditions unique to the thymus induce a complex series of developmental events in ..
  15. Stromal catalase deficiency as the causative factor in accelerated thymic atrophy
    Howard T Petrie; Fiscal Year: 2013
    ..The thymus is the primary site of T lymphopoiesis. However, the thymus is characterized by an accelerated, age-related atrophy, leading to a progressive decline ..
  16. Role of B-cell oncogenes and microRNA-34 in B-lymphopoiesis and neoplasia
    Dinesh S Rao; Fiscal Year: 2013
    ..Hence, these studies have a direct relevance to public health and most importantly, to patients living with these diseases. ..
  17. HSC Diversity: Regulation by Clonal Selection vs Epigenetic Induction
    Irving L Weissman; Fiscal Year: 2013
    ..we demonstrated a skewing in blood cell lineage representation as mice and humans age, from a balance between lymphopoiesis and myelomonocytopoiesis in young adult life, to a predominance of myelomonocytopoiesis in the elderly...
  18. Lymphopoietic development in the extra-embryonic yolk sac
    Mervin C Yoder; Fiscal Year: 2013
    ..Indeed, the most formidable obstacle encountered when attempting to define the onset of B lymphopoiesis in the developing murine embryo, is the onset of cardiac contractions and establishment of the circulation...
  19. Chaperone Mechanisms in Innate Immunity
    Zihai Li; Fiscal Year: 2013
    ..can rescue the expression of both TLRs and integrins in gp96 KO murine cells;(iv) gp96 is critical for T and B lymphopoiesis but not myelopoiesis;(v) the folding of TLRs by gp96 is dependent on a substrate (TLR)-specific co-chaperone, ..
  20. Notch-induced protein degradation in lymphopoiesis
    Xiao Hong Sun; Fiscal Year: 2013
    ..There is good reason to believe the answers to these questions will lead to new treatments for several types of diseases. These include leukemias and cancers of the breast or intestine, autoimmune diseases and developmental defects. ..
  21. Human B1 Lymphopoiesis
    Thomas L Rothstein; Fiscal Year: 2013
    ..To achieve this goal, several specific aims will be pursued to: 1) Establish a model system for lymphopoiesis that fosters the development of B1 cells from cord blood and/or bone marrow hematopoietic stem cells through ..
  22. Androgen Receptor in B Cell Development and Functions
    Chawnshang Chang; Fiscal Year: 2010
    ..of B cells in the bone marrow and peripheral blood, suggesting that AR plays a negative regulatory role in B lymphopoiesis. The overall objective of this proposal is to elucidate the mechanism through which AR regulates B ..
  23. Role of Extrinsic and Intrinsic Factors Responsible for Aging of Immune System
    Ian Rogers; Fiscal Year: 2013
    ..population is detrimentally affected by aging as reflected by its inability to maintain both hematopoiesis and lymphopoiesis. Mice, the most common research model, although inexpensive, do not necessarily reflect the human immune ..
  24. IMMUNOBIOLOGY OF B CELL DIFFERENTIATION
    KENNETH ALLAN DORSHKIND; Fiscal Year: 2013
    Project Description/Abstract Numerous studies have revealed differences in the transcriptional regulation of B lymphopoiesis in the embryo and the adult...
  25. Visualization and Lineage Tracing of Hematopoietic Stem Cell Heterogeneity
    Boris Reizis; Fiscal Year: 2013
    ..The latter subset becomes predominant with age, limiting lymphopoiesis and predisposing to myeloproliferation...
  26. HETEROCHROMATIN RECRUITMENT OF THE VPAC1 LOCUS BY IKAROS
    Glenn Paul Dorsam; Fiscal Year: 2010
    ..Ikaros is a master regulator of lymphopoiesis and sets the threshold for T cell activation...
  27. Stem Cell Therapies for Primary Immune Deficiency
    GAY MIRIAM CROOKS; Fiscal Year: 2010
    ..with SCID provides a unique biological and clinical setting to unravel mechanisms of stem cell engraftment, lymphopoiesis and immune reconstitution...
  28. Supplementation of cord blood transplants with limphoid progenitors
    Britte C Beaudette Zlatanova; Fiscal Year: 2010
    ..to support B cell development, we will explore whether adherent cells of the omentum, a site of fetal B lymphopoiesis, can provide an appropriate microenvironment for the expansion and differentiation of CB HSC...
  29. Extrathymic T cell precursors: commitment and efficacy
    Harald von Boehmer; Fiscal Year: 2012
    The nature of thymus immigrants that contribute most effectively to T lymphopoiesis is unknown even though several well-characterized progenitors have been described...
  30. Inflammasomes and the mechanism of thymic demise in aging
    Vishwa Deep Dixit; Fiscal Year: 2013
    ..canonical Nlrp3 Inflammasome dependent mechanism induces 'thymic inflammaging'and compromises thymic lymphopoiesis by impacting the integrity of thymic epithelial cells...
  31. The role of Ikaros in regulation of Notch target gene expression
    SUSAN M WINANDY; Fiscal Year: 2010
    Ikaros is a nuclear protein and key regulator of T lymphopoiesis. Ikaros deficiency in mice results in abnormal T cell development and, with 100% penetrance, T cell leukemogenesis...
  32. Regulation of B Cell Development and Function by Zfp521
    JAMES R HAGMAN; Fiscal Year: 2013
    ..Co-occupancy of Zfp521 and EBF1 on these genes suggests a new model for co-regulation of B lymphopoiesis. In this manner, EBF1, the B lineage determination factor, is regulated by Zfp521 in developing B cells...
  33. c-Myb controls survival, proliferation and differentiation during B-lymphopoiesis
    Timothy P Bender; Fiscal Year: 2013
    ..The goal of this proposal is to develop the network of crucial genes that mediate c-Myb activity during different stages of B cell development. ..
  34. The Osteoblast as a Determinant of Leukemogenesis
    Stavroula Kousteni; Fiscal Year: 2013
    ..Concomitantly, B- lymphopoiesis is compromised...
  35. A Novel Hybrid Multifunctional Cytokine for Immune Reconstitution
    Susan C Wright; Fiscal Year: 2012
    ..on the known properties of IL-7, Ha7 is predicted promote immune reconstitution by stimulating T and B cell lymphopoiesis as well as homeostatic maintenance of mature T cells...
  36. Engineering hematopoietic progenitors for efficient migration to the thymus
    Avinash Bhandoola; Fiscal Year: 2010
    ..the physiologically relevant progenitors that express these homing molecules and so contribute to T lymphopoiesis. We present data suggesting that the generation of thymic homing progenitors is deficient in aged mice...
  37. Identification and Functional Analysis of Novel Determiners of B Lymphopoiesis
    KEITH MICHAEL HAMEL; Fiscal Year: 2013
    ..Discrete stages of proliferation and differentiation of B lymphopoiesis are regulated by the coordinate expression of lineage and stage specific genes...
  38. GATA3 deregulation and T cell transformation in E2A-/- mice
    BARBARA LYNNE KEE; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): GATA3 is an essential transcription factor for T lymphopoiesis but elevated expression of GATA3 can derail T cell differentiation and promote transformation...
  39. TCF/Lef Signaling in Lymphopoiesis
    Kristine Germar; Fiscal Year: 2010
    ..Defects in these signaling cascades are likely to contribute to developmental diseases and leukemic transformation. Understanding these molecular processes will help design diagnostic tests and targeted therapies for these diseases ..
  40. Myc-directed control of mRNA turnover in lymphopoiesis and lymphomagenesis
    John L Cleveland; Fiscal Year: 2013
    ..We submit the proposed studies will identify new targets that play key roles in lymphopoiesis and that can be exploited for the development of new anti-lymphoma drugs that are likely to have activity ..
  41. Selection of B cell repertoire in senescence
    Richard L Riley; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): B lymphopoiesis is severely compromised in murine senescence...
  42. Defining the Earliest Stages of Lymphoid Commitment in Human Bone Marrow
    LISA ANN KOHN; Fiscal Year: 2012
    ..provided by applicant): A large number of reports continue to refine the differentiation stages of murine lymphopoiesis. However very little is known about the earliest stages of human lymphoid differentiation, those few reports ..
  43. Aging-associated alterations in adaptive landscapes and the evolution of leukemia
    James V DeGregori; Fiscal Year: 2013
    ..oncogenic adaptation and leukemogenesis, and 3) dissect the molecular mechanisms underlying impaired B-lymphopoiesis and increased selection for particular oncogenes in old age...
  44. The effect of niche-specific cxcl12 production on B lymphopoiesis.
    RYAN BRENT DAY; Fiscal Year: 2013
    ..applicant): The objective of this research is to define the role of niche-specific production of CXCL12 in B lymphopoiesis. In response to infection, there is a dramatic increase in neutrophil production (granulopoiesis) in the bone ..
  45. Skeletal development and the hematopoietic niche
    Olena Jacenko; Fiscal Year: 2013
    ..defects including altered hypertrophic cartilage and trabecular bone in the COJ, marrow hypoplasia, diminished lymphopoiesis, and impaired immune function...
  46. THYMUS 2012 INTERNATIONAL CONFERENCE
    Janko Nikolich-Zugich; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The ThymUS 2012 International Conference on Lymphopoiesis, T cell Differentiation and Immune Reconstitution will be held in Sunny Isles Beach, FL, from Nov 4-9. 2012...
  47. lymphostromal interactions in the thymic aging
    Dong Ming Su; Fiscal Year: 2010
    Aging causes thymic involution which decreases thymic lymphopoiesis and exhausts the naive T-cell pool, constricting diversity of T-cell receptor repertoire and inducing immunosenescence...
  48. GATA3 regulation in transcriptional networks during hematopoietic cell developmen
    James Douglas Engel; Fiscal Year: 2013
    ..Thus GATA-3 is required at the earliest stage of T lymphopoiesis as well as at intermediate and late stages of thymocyte development and for CD4+ T cell Th2 differentiation in ..
  49. TSLP receptor in the regulation of cell development
    Steven F Ziegler; Fiscal Year: 2010
    ..immune system, which includes the proper expression and function of cytokines and their cognate receptors, hi lymphopoiesis, interleukin (IL)-7 has been shown to be a critical component of both T and B cell development...
  50. PLC?s in B cell biology and autoimmunity
    Demin Wang; Fiscal Year: 2012
    ..and PLC32 genes, we are well-positioned to further study the individual and combined roles of PLC31/PLC32 in B lymphopoiesis, including tolerance establishment, and the mechanism by which both PLC3s regulate the process...
  51. Ikaros regulation: study on hemo-lymphopoiesis
    Katia Georgopoulos; Fiscal Year: 2013
    ..Exploitation of the Ikaros gene targets or their transcriptional and epigenetic mechanisms of regulation may empower the design of new intelligent/tailored diagnostics and therapies for high-risk B-ALL. . ..
  52. Trypanosoma brucei-induced dyshematopoiesis: blocked B lymphopoiesis
    Samuel Black; Fiscal Year: 2009
    ..These observations lead us to hypothesize that T. brucei induces a reversible block in B lymphopoiesis that prevents replenishment of the pools of new and mature B cell, which leads to B- cell clonal exhaustion ..
  53. Migration of hematopoietic progenitors to the thymus
    Avinash Bhandoola; Fiscal Year: 2013
    ..or inhibition of homing molecules will allow a broader range of blood progenitors to migrate to the thymus and improve T lymphopoiesis after bone marrow transplantation, and understand what the underlying mechanisms might be. !
  54. Early T lineage progenitors
    Avinash Bhandoola; Fiscal Year: 2013
    ..we think that more proliferation may occur immediately after thymic settling than at any subsequent stage of T lymphopoiesis. One goal of our current proposal is to quantify this proliferation, and to determine how it is regulated...
  55. IMMUNOBIOLOGY OF B CELL DIFFERENTIATION
    Kenneth Dorshkind; Fiscal Year: 1991
    ..The Whitlock-Witte lymphoid bone marrow cultures (LBMC) allow long-term B lymphopoiesis. The MBMC B cell precursor can be induced to differentiate into B cells following switching to LBMC conditions...
  56. DIETARY ZINC-ITS EFFECTS ON THE IMMUNE RESPONSE
    Pamela Fraker; Fiscal Year: 2007
    ..Accelerated apoptosis disrupts lymphopoiesis creating lymphopenia, but splenic lymphocytes of the ZD mouse have greater potency...
  57. REGULATION OF HEMOPOIESIS BY STROMAL CELLS
    Kenneth Dorshkind; Fiscal Year: 1993
    ..studies have shown that CSFs stimulate myelopoiesis, but secondary effects on other lineages, particularly lymphopoiesis, have not been examined in detail...
  58. High-speed Flow Cytometer
    Kenneth Weinberg; Fiscal Year: 2003
    ..development after hematopoietic stem cell transplantation (HSCT), and the function of cytokine receptors in lymphopoiesis. Again, these studies depend on combined antibody and EGFP-based assays as well as nucleic acid staining to ..
  59. B CELL REPERTOIRE OF NORMAL AND AUTOIMMUNE MICE
    Richard Riley; Fiscal Year: 1992
    ..B) Define whether the mechanisms responsible for defective B lymphopoiesis in NZ mice operate at the precursor cell level or upon the non-lymphoid stroma necessary for the support of B ..
  60. IL-7R and c-kit interactions in thymopoiesis
    Kenneth Weinberg; Fiscal Year: 2006
    ..of the c-kit or KL loci are well appreciated, the c-kit pathway can also significantly contribute to T lymphopoiesis. Mice with mutations of either KL or c-kit have defective thymopoiesis, which can be corrected by ..
  61. SCREEN FOR LYMPHOID MUTANTS
    Nikolaus Trede; Fiscal Year: 2004
    During lymphopoiesis a pluripotent stem cell develops into T or B lymphocytes. The thymus provides a specialized environment for terminal T lymphocyte differentiation...
  62. Regulation of lymphocyte survival by NF-kB proteins
    Amer Beg; Fiscal Year: 2004
    ..1) We show here an impairment of lymphopoiesis following adoptive transfer of ReIA-/- fetal liver cells into irradiated lymphocyte-deficient Rag1-/- mice...
  63. MOLECULAR CONTROL OF ANTIGEN RECEPTOR GENE ASSEMBLY
    Eugene Oltz; Fiscal Year: 2000
    ..Proper targeting of these events is pivotal to lymphopoiesis; aberrations can produce chromosomal translocations that result in lymphoid tumors...
  64. Role of Plexin D1 in thymic development
    Linda Clayton; Fiscal Year: 2009
    ..b>Lymphopoiesis of the T lineage in the thymus proceeds in a directional manner such that early double negative (DN) ..
  65. ROLE OF IL-7 IN DECREASED THYMOPOIESIS OF AGING
    Marilyn Thoman; Fiscal Year: 2006
    ..from Investigator's abstract) With advancing age the thymus undergoes involution resulting in reduced T lymphopoiesis. This decrease in T cell output from the thymus is thought to have a significant impact on the composition and ..
  66. Control of T Lymphopoiesis and Growth by Mad Genes
    Brian Iritani; Fiscal Year: 2007
    ..abstract_text> ..