Genomes and Genes
Summary: Formation of LYMPHOCYTES and PLASMA CELLS from the lymphoid stem cells which develop from the pluripotent HEMATOPOIETIC STEM CELLS in the BONE MARROW. These lymphoid stem cells differentiate into T-LYMPHOCYTES; B-LYMPHOCYTES; PLASMA CELLS; or NK-cells (KILLER CELLS, NATURAL) depending on the organ or tissues (LYMPHOID TISSUE) to which they migrate.
Publications291 found, 100 shown here
- Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell developmentKyongrim Kwon
Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Immunity 28:751-62. 2008The transcription factor E2A controls the initiation of B lymphopoiesis, which is arrested at the pre-pro-B cell stage in E2A-deficient mice...
- A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fateYin C Lin
Department of Molecular Biology, University of California, San Diego, La Jolla, California, USA
Nat Immunol 11:635-43. 2010..From this analysis we constructed a global network consisting of transcriptional regulators, signaling and survival factors that we propose orchestrates B cell fate...
- Regulation of microRNA expression and abundance during lymphopoiesisStefan Kuchen
Genomics and Immunity, NIAMS, NIH, Bethesda, MD 20892, USA
Immunity 32:828-39. 2010..We applied miRNA-, mRNA-, and ChIP-Seq to characterize the microRNome during lymphopoiesis within the context of the transcriptome and epigenome...
- An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11bLong Li
Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
Science 329:89-93. 2010....
- The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenanceTerry J Fry
Immunology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 174:6571-6. 2005..Thus, IL-7 plays critical and nonredundant roles in both T cell lymphopoiesis and in maintaining and restoring peripheral T cell homeostasis.
- Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic miceDelphine Guy-Grand
Unité de Biologie Moléculaire du Gène, INSERM U277 and Institut Pasteur, 75724 Paris Cedex 15, France
J Exp Med 197:333-41. 2003..In athymic mice, T lymphopoiesis occurs mainly in the mesenteric lymph node and less in the Peyer's patches...
- Bcl11a is essential for normal lymphoid developmentPentao Liu
Mouse Cancer Genetics Program, National Cancer Institute Frederick, Maryland 21702, USA
Nat Immunol 4:525-32. 2003..Here we show that Bcl11a is essential for postnatal development and normal lymphopoiesis. Bcl11a mutant embryos lack B cells and have alterations in several types of T cells...
- HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesisDelphine Sauce
INSERM UMR S 945, Infections and Immunity, Avenir Group, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
Blood 117:5142-51. 2011..CD4(+) T-cell levels probably depends primarily on the capacity to renew depleted lymphocytes, that is, the lymphopoiesis. We performed here a comprehensive study of quantitative and qualitative attributes of CD34(+) hematopoietic ..
- An essential developmental checkpoint for production of the T cell lineageTomokatsu Ikawa
Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Yokohama 230 0045, Japan
Science 329:93-6. 2010..Our study thus identifies the earliest checkpoint during T cell development and shows that it is Bcl11b-dependent...
- A human thymic epithelial cell culture system for the promotion of lymphopoiesis from hematopoietic stem cellsBritte C Beaudette-Zlatanova
Department of Microbiology and Immunology Stritch School of Medicine, Loyola University Chicago, 2160 First Avenue, Maywood, IL 60153, USA
Exp Hematol 39:570-9. 2011..antigen-ABC and human leukocyte antigen-DR was engineered to overexpress murine Delta-like 1 (TEC-Dl1) for the purpose of establishing a human culture system that supports T lymphopoiesis from hematopoietic progenitor cells (HPCs).
- The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrowOwen M Siggs
Department of Genetics, The Scripps Research Institute, La Jolla, California, USA
Nat Immunol 12:434-40. 2011B lymphopoiesis begins in the fetal liver, switching after birth to the bone marrow, where it persists for life. The unique developmental outcomes of each phase are well documented, yet their molecular requirements are not...
- Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell developmentStephen Malin
Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria
Nat Immunol 11:171-9. 2010STAT5 and interleukin 7 (IL-7) signaling are thought to control B lymphopoiesis by regulating the expression of key transcription factors and by activating variable (V(H)) gene segments at the immunoglobulin heavy-chain (Igh) locus...
- Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesisUte Koch
Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Federale de Lausanne EPFL, Epalinges, Switzerland
Blood 111:160-4. 2008..of beta-catenin (which is considered to be essential for Wnt signaling) has no effect on hematopoiesis or lymphopoiesis. Here, we address whether this discrepancy can be explained by a redundant and compensatory function of gamma-..
- Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesisJoan Yuan
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health, Bethesda, MD 20892, USA
Science 335:1195-200. 2012..bone marrow, which endows them with the ability to mediate multilineage reconstitution that resembles fetal lymphopoiesis, including increased development of B-1a, marginal zone B, gamma/delta (γδ) T cells, and natural killer T (..
- Beta-catenin is dispensable for hematopoiesis and lymphopoiesisMonica Cobas
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
J Exp Med 199:221-9. 2004..In contrast to earlier reports, these data exclude an essential role for beta-catenin during hematopoiesis and lymphopoiesis.
- Aging induced decline in T-lymphopoiesis is primarily dependent on status of progenitor niches in the bone marrow and thymusLiguang Sun
Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
Aging (Albany NY) 4:606-19. 2012..organismal age, but aging in niche cells occurred much earlier than in LPCs by an observation in thymic T-lymphopoiesis. Therefore, the aging induced decline in competence to generate T cells is primarily dependent on status of ..
- A critical role for Rictor in T lymphopoiesisFei Tang
Division of Immunotherapy, Department of Surgery, University of Michigan Medical School and Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
J Immunol 189:1850-7. 2012Apart from a critical role for Notch and pre-TCR, the signaling pathway required for T lymphopoiesis is largely unknown...
- Development of human lymphoid cellsBianca Blom
Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands
Annu Rev Immunol 24:287-320. 2006....
- Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasisChristos Gekas
Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
Blood 113:3461-71. 2009..In summary, this work identifies Mef2C as an integral member of hematopoietic transcription factors with distinct upstream regulatory mechanisms and functional requirements in megakaryocyte and B-lymphoid lineages...
- The ageing immune system: is it ever too old to become young again?Kenneth Dorshkind
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California 90095, USA
Nat Rev Immunol 9:57-62. 2009..But is the immune system ever too old to become young again? We review here the promise of various approaches to rejuvenate the function of the immune system in the rapidly growing ageing population...
- Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with agingLisa M Guerrettaz
Department of Immunology, University of Colorado, Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA
Proc Natl Acad Sci U S A 105:11898-902. 2008..We tested the hypothesis that aging-associated repertoire changes can be attributed directly to decreased B lymphopoiesis. Using an Ig transgenic model to report changes in the B-cell repertoire, we show that the reduced B-cell ..
- Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cellsGeneve Awong
Department of Immunology, University of Toronto, Toronto, ON, Canada
Blood 114:972-82. 2009..Taken together, the identification of T-progenitor subsets readily generated in vitro may offer important avenues to improve cellular-based immune-reconstitution approaches...
- Regulation of gammadelta versus alphabeta T lymphocyte differentiation by the transcription factor SOX13Heather J Melichar
Department of Pathology, Graduate Program in Immunology and Virology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
Science 315:230-3. 2007..Our data thus reveal a dominant pathway regulating the developmental fate of these two lineages of T lymphocytes...
- Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesisThorsten Decker
Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
Immunity 30:508-20. 2009..These experiments demonstrate a stepwise activation of Pax5 in early lymphopoiesis and provide mechanistic insights into the process of B cell commitment.
- gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesisMatthew Staron
Department of Immunology, University of Connecticut School of Medicine, Farmington, CT 06030 1601, USA
Blood 115:2380-90. 2010Integrins contribute to lymphopoiesis, whereas Toll-like receptors (TLRs) facilitate the myeloid replenishment during inflammation. The combined role of TLRs and integrin on hematopoiesis remains unclear...
- IL-7 specifies B cell fate at the common lymphoid progenitor to pre-proB transition stage by maintaining early B cell factor expressionKazu Kikuchi
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 181:383-92. 2008..However, it was not clear when IL-7 stimulation is necessary in hemato-/lymphopoiesis in adult mice...
- Reprogramming of T cells to natural killer-like cells upon Bcl11b deletionPeng Li
Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
Science 329:85-9. 2010..Therefore, ITNKs may represent a new cell source for cell-based therapies...
- Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversibleHiromi Tagoh
Molecular Medicine Unit, St James s University Hospital, University of Leeds, Leeds LS9 7TF, UK
EMBO J 23:4275-85. 2004..To examine the role of chromatin structure in this process we studied epigenetic silencing of c-fms during B-lymphopoiesis. c-fms chromatin in stem cells and multipotent progenitors is in the active conformation and bound by ..
- Receptor editing in positive and negative selection of B lymphopoiesisEfrat Edry
Department of Immunology, Faculty of Medicine, Technion, Israel
J Immunol 173:4265-71. 2004In B lymphopoiesis, Ag receptor expression and signaling are critical to determine developmental progression, survival, and activation...
- A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunityHeon Park
Department of Comparative Medicine, University of Washington, Seattle, WA 98195, USA
J Exp Med 205:2899-913. 2008....
- Identification of a T lineage-committed progenitor in adult bloodAndreas Krueger
Harvard Medical School, Dana Farber Cancer Institute, Boston, MA 02115, USA
Immunity 26:105-16. 2007..Thus, CTP represent T lineage-committed T cell precursors linking extrathymic with intrathymic lymphopoiesis in adult mice.
- Asynchronous RAG-1 expression during B lymphopoiesisRobert S Welner
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
J Immunol 183:7768-77. 2009..These findings indicate that essential events in B lymphopoiesis are not tightly synchronized...
- Alphabeta versus gammadelta lineage choice at the first TCR-controlled checkpointTaras Kreslavsky
Laboratory of Lymphocyte Biology, Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
Curr Opin Immunol 22:185-92. 2010..Recent experiments support the former view...
- Key role of flt3 ligand in regulation of the common lymphoid progenitor but not in maintenance of the hematopoietic stem cell poolEwa Sitnicka
Department of Stem Cell Biology, Institute of Laboratory Medicine, University Hospital of Lund, BMC, B12, Klinikgatan 26, 221 84 Lund, Sweden
Immunity 17:463-72. 2002..Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC...
- Epigenetic events during B lymphocyte developmentMaribel Parra
Cellular Differentiation Group, Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute, Barcelona, Spain
Epigenetics 4:462-8. 2009..field have made significant advances towards understanding the contribution of transcription factors during B lymphopoiesis.They have established the existence of transcription factor networks that are essential for the proper ..
- B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in agingZohar Keren
Department of Immunology, Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
Blood 117:3104-12. 2011Aging is associated with a decline in B-lymphopoiesis in the bone marrow and accumulation of long-lived B cells in the periphery. These changes decrease the body's ability to mount protective antibody responses...
- HAX1 deficiency: impact on lymphopoiesis and B-cell developmentDoris Peckl-Schmid
Department of Molecular Biology, University of Salzburg, Salzburg, Austria
Eur J Immunol 40:3161-72. 2010..Hax1(-/-) B cells show a significantly reduced expression of CXCR4, which might have an influence on the observed defects in B-cell development...
- Enhancement of hematopoiesis and lymphopoiesis in diet-induced obese miceMark D Trottier
Biochemistry and Molecular Biology Department, Michigan State University, East Lansing, MI 48824, USA
Proc Natl Acad Sci U S A 109:7622-9. 2012..Leptin, which promotes lymphopoiesis and myelopoiesis, reached 100 ng/mL in sera from HFD mice...
- Human induced pluripotent stem cells are capable of B-cell lymphopoiesisLee Carpenter
Stem Cell Research Laboratory, National Health Service Blood and Transplant, John Radcliffe Hospital, Oxford, UK
Blood 117:4008-11. 2011..We therefore have been able to demonstrate, for the first time, that human iPS cells are able to undergo hematopoiesis that contributes to the B-cell lymphoid lineage...
- The B-cell identity factor Pax5 regulates distinct transcriptional programmes in early and late B lymphopoiesisRoger Revilla-i-Domingo
Department of Immunology, Research Institute of Molecular Pathology, Vienna Biocenter, Austria
EMBO J 31:3130-46. 2012..Hence, Pax5 controls B-cell identity and function by regulating distinct target genes in early and late B lymphopoiesis.
- Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistanceKirsteen J Campbell
Molecular Genetics of CancerDivision, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville 3052, Victoria, Australia
Blood 116:3197-207. 2010..Myelopoiesis was relatively normal, but lymphopoiesis was clearly perturbed, with excess mature B and T cells accumulating...
- In interleukin-7-transgenic mice, increasing B lymphopoiesis increases follicular but not marginal zone B cell numbersRhodri Ceredig
Unité 548 INSERM, DRDC, Commissariat a l Energie Atomique Grenoble, Grenoble, France
Eur J Immunol 33:2567-76. 2003..In situations of decreased bone marrow B lymphopoiesis, the proportion of spleen marginal zone B cells increases, but the consequence of increasing B lymphopoiesis ..
- Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesisCecile Huin-Schohn
Department of Development and Immunogenetics, Lorraine University, Vandoeuvre les Nancy, France
FASEB J 27:333-41. 2013..Taken together, and given that the larvae were not immunized, these data suggest a modification of lymphopoiesis when gravity changes occur during ontogeny.
- The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitorsFabian Zohren
Department of Haematology, Oncology and Clinical Immunology, Heinrich Heine University, Dusseldorf, Germany
Nat Immunol 13:761-9. 2012..We identified Gfi1 as a critical transcriptional target of Lyl-1-mediated lymphopoiesis of T cells...
- Cell migration and the control of post-natal T-cell lymphopoiesis in the thymusHoward T Petrie
Laboratory of Developmental Immunology, Memorial Sloan Kettering Cancer Center, New York 10021, USA
Nat Rev Immunol 3:859-66. 2003
- FOXN1 mutation abrogates prenatal T-cell development in humansI Vigliano
Department of Pediatrics, Federico II University, Via Pansini, 5, Naples 80131, Italy
J Med Genet 48:413-6. 2011....
- Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesisJianjun Shi
Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL, USA
Blood 118:2511-9. 2011Notch1 signaling is absolutely essential for steady-state thymic lymphopoiesis, but the role of other Notch receptors, and their potential overlap with the function of Notch1, remains unclear...
- Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cellsErin C Zook
Cell Biology, Neurobiology and Anatomy Graduate Program, Stritch Shool of Medicine, Loyola University Chicago, Maywood, IL, USA
Blood 118:5723-31. 2011..Our data indicate that manipulation of Foxn1 expression in the thymus ameliorates thymopoiesis in aged mice and offer a strategy to combat the age-associated decline in naive T-cell production and CD4 naive/memory ratios in the elderly...
- Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRFTakahiro Maeda
Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Science 316:860-6. 2007..We propose a new model for lymphoid lineage commitment, in which LRF acts as a master regulator of the cell's determination of B versus T lineage...
- Critical roles for c-Myb in lymphoid priming and early B-cell developmentKylie T Greig
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Blood 115:2796-805. 2010..c-Myb-deficient mice display reduced numbers of B cells; however, it is unknown what role c-Myb plays in B lymphopoiesis because no critical target genes have been identified in the B-cell lineage...
- Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemiaRobert A J Signer
Department of Pathology and Laboratory Medicine and Hematopoietic Malignancies Program, Jonsson Comprehensive Cancer Center, Los Angels, CA 90095, USA
Blood 110:1831-9. 2007Reduced lymphopoiesis during aging contributes to declines in immunity, but little consideration has been given to its effect on the development of hematologic disease...
- Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor proteinSatoshi Takaki
Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan
J Immunol 170:703-10. 2003..Our results illuminate the novel negative regulatory mechanism mediated by the Lnk adaptor protein in controlling lymphocyte production and function...
- Effects of aging on the common lymphoid progenitor to pro-B cell transitionHyeyoung Min
Department of Pathology and Laboratory Medicine and Hemopoietic Malignancies Program, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 176:1007-12. 2006..These age-related changes in early B lymphopoiesis do not result from a general defect in HSC or the bone marrow microenvironment that impairs development in all ..
- Lineage relationship analysis of RORgammat+ innate lymphoid cellsShinichiro Sawa
Lymphoid Tissue Development Unit, Institut Pasteur, 75724 Paris, France
Science 330:665-9. 2010..Contrary to RORγt(+) T cells, however, RORγt(+) ILCs develop in the absence of microbiota. Our study indicates that RORγt(+) ILCs evolve to preempt intestinal colonization by microbial symbionts...
- Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesisTakafumi Yokota
Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
J Immunol 181:6061-72. 2008It has long been known that lymphopoiesis is transiently suppressed during pregnancy, which can be experimentally simulated by estrogen treatment...
- B lineage-specific regulation of V(D)J recombinase activity is established in common lymphoid progenitorsLisa Borghesi
Molecular Genetics and Microbiology, University of Massachusetts Medical School, 55 Lake Ave North, Worcester 01655, USA
J Exp Med 199:491-502. 2004..As activity of the Erag enhancer is restricted to the B cell lineage, this provides the first molecular evidence for establishment of a lineage-specific transcription program in multipotent progenitors...
- Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineageTatiana Corbeaux
Max Planck Institute of Immunobiology, Freiburg D 79108, Germany
Proc Natl Acad Sci U S A 107:16613-8. 2010..Our findings therefore support the notion that Foxn1 is the essential transcription factor regulating the differentiation of TECs and that its expression marks the major functional lineage of TECs in embryonic and adult thymic tissue...
- Frizzled 9 knock-out mice have abnormal B-cell developmentErik A Ranheim
Departments of Pathology and Genetics, Stanford University School of Medicine, Stanford, CA, USA
Blood 105:2487-94. 2005..Mature B cells are present in normal numbers in lymph node and spleen. These findings suggest a role for Fzd9 signaling in lymphoid development, particularly at points where B cells undergo self-renewal prior to further differentiation...
- The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesisPing Lu
Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
J Exp Med 207:1359-67. 2010A recessive mutation named Justy was found that abolishes B lymphopoiesis but does not impair other major aspects of hematopoiesis...
- Awakening lineage potential by Ikaros-mediated transcriptional primingToshimi Yoshida
Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Curr Opin Immunol 22:154-60. 2010..Loss of Ikaros removes the lymphoid leg of the immune system and may confer aberrant self-renewing properties to myeloid progenitors...
- Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2cSandra Stehling-Sun
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Nat Immunol 10:289-96. 2009..1 during lymphopoiesis. Thus, Mef2c is a crucial component of the transcriptional network that regulates cell fate 'choice' in ..
- Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cellsJiang Zhu
Department of Medicine, Division of Hematology Oncology, University of Pennsylvania School of Medicine, 3600 Spruce Street, Philadelphia, PA 19104, USA
Blood 109:3706-12. 2007Early B lymphopoiesis in mammals is induced within the bone marrow (BM) microenvironment, but which cells constitute this niche is not known...
- Alterations of the systemic environment are the primary cause of impaired B and T lymphopoiesis in telomere-dysfunctional miceZhangfa Song
Institute of Molecular Medicine and Max Planck Research Group on Stem Cell Aging, University of Ulm, Ulm, Germany
Blood 115:1481-9. 2010There is growing evidence that telomere dysfunction can contribute to human aging. Telomere dysfunction limits lymphopoiesis in aging telomerase knockout (mTerc(-/-)) mice primarily by the induction of stem cell-extrinsic alterations...
- Activation of thymic regeneration in mice and humans following androgen blockadeJayne S Sutherland
Department of Immunology, Monash University Medical School, Prahran, Victoria, Australia
J Immunol 175:2741-53. 2005..Collectively these studies represent a fundamentally new approach to treating immunodeficiency states in humans...
- Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunctionMichael L Chen
Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Blood 114:4045-53. 2009..macrocytic anemia with abnormal erythroid maturation and megaloblastic changes, as well as profound defects in lymphopoiesis. Mice die of severe fatal anemia at 15 months of age...
- Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironmentSofie Singbrant
St Vincent s Institute of Medical Research and Department of Medicine at St Vincent s Hospital, University of Melbourne, Fitzroy, Victoria, Australia
Blood 117:5631-42. 2011..Surprisingly, we also found that Epo induced a rapid 26% loss of the trabecular bone volume and impaired B-lymphopoiesis within the bone marrow microenvironment...
- Regulation of B-cell fate by antigen-receptor signalsHiroaki Niiro
Department of Microbiology, University of Washington, Seattle, Washington 98195, USA
Nat Rev Immunol 2:945-56. 2002..Recent progress in unravelling the molecular mechanisms of the BCR signalling pathways has helped to clarify how BCR signals regulate the proliferation, survival and apoptosis of developing B cells...
- B lymphopoiesis is active throughout human life, but there are developmental age-related changesMaria Isabel D Rossi
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
Blood 101:576-84. 2003This study addressed several questions concerning age-related changes in human B lymphopoiesis. The relative abundance of pro-B, pre-B, immature, naive, and mature B cells among the CD19(+) lymphocyte fraction of human bone marrow was ..
- B-cell development fails in the absence of the Pbx1 proto-oncogeneMrinmoy Sanyal
Department of Pathology, Stanford University, School of Medicine, Stanford, CA 94305, USA
Blood 109:4191-9. 2007..from Pbx1-deficient fetal liver cells was also severely compromised, but not erased, since transient B lymphopoiesis was detected in Rag-deficient recipients...
- Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapyAnnette Deichmann
Institute for Molecular Medicine and Cell Research and Department of Internal Medicine I, German Cancer Research Center, University of Freiburg, Freiburg, Germany
J Clin Invest 117:2225-32. 2007..Beyond the observed cases of insertional mutagenesis in 3 patients, these data help to elucidate the relationship between vector insertion and long-term in vivo selection of transduced cells in human patients with SCID-X1...
- Sustained activation of cell adhesion is a differentially regulated process in B lymphopoiesisAleksandra M Glodek
Joint Program in Transfusion Medicine, Harvard Medical School, Children s Hospital Boston, Boston, MA 02115, USA
J Exp Med 197:461-73. 2003..These results provide a developmental cell stage-specific mechanism by which chemokines orchestrate hematopoiesis through sustained rather than transient activation of adhesion and cell survival pathways...
- Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneityRobert Mansson
Department for Clinical and Experimental Sciences, Linkoping University, Linkoping, Sweden
Blood 115:2601-9. 2010..These data suggest that the classic common lymphoid progenitor compartment composes a mixture of cells with relatively restricted lineage potentials, thus opening new possibilities to investigate early hematopoiesis...
- Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signallingMarcus R Clark
Section of Rheumatology and Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Illinois 60637, USA
Nat Rev Immunol 14:69-80. 2014....
- Insights on FoxN1 biological significance and usages of the "nude" mouse in studies of T-lymphopoiesisZhijie Zhang
Department of Molecular Biology and Immunology, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX 76107, USA
Int J Biol Sci 8:1156-67. 2012..We also raise questions and propose further consideration of FoxN1 functions and utilizing this mouse model for immune function studies...
- Radical reversal of vasoactive intestinal peptide (VIP) receptors during early lymphopoiesisEmilie E Vomhof-DeKrey
Department of Chemistry and Biochemistry, North Dakota State University, Fargo, ND 58102, USA
Peptides 32:2058-66. 2011..that a high VPAC1:VPAC2 ratio in the earliest thymocyte progenitors (ETP cells) would be reversed during early lymphopoiesis as observed in activated, peripheral Th(2) cells, as the thymus is rich in Th(2) cytokines...
- Strength of signal: a fundamental mechanism for cell fate specificationSandra M Hayes
Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA
Immunol Rev 209:170-5. 2006..In this review, we compare the alphabeta/gammadelta fate decision with other cell fate decisions that occur outside of the lymphoid system to attain a better picture of the quantitative signaling mechanism for cell fate specification...
- Overexpression of a hematopoietic transcriptional regulator EDAG induces myelopoiesis and suppresses lymphopoiesis in transgenic miceC Y Li
Department of Biochemistry and Molecular Biology, Beijing Institute of Radiation Medicine, Beijing, China
Leukemia 21:2277-86. 2007..In contrast to myeloid cells, the lymphoid commitment was severely impaired with the B lymphopoiesis blocked at the transition from pro/pre-B I to pre-B II stage in BM and T thymocytes development blocked at the ..
- Non-cell-autonomous hedgehog signaling promotes murine B lymphopoiesis from hematopoietic progenitorsChristopher L Cooper
Department of Molecular Biology and Genetics and Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Blood 119:5438-48. 2012The role of hedgehog (Hh) signaling in B lymphopoiesis has remained unclear...
- A checkpoint in B-lymphopoiesis related to Notch resistanceKazuki Okuyama
Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan
Biochem Biophys Res Commun 417:141-6. 2012While murine B- and T-lymphopoiesis require overlapping molecules, they occur in separate organs: the bone marrow (BM) and the thymus, respectively...
- A genetic locus controlling aging-sensitive regression of B lymphopoiesis in an autoimmune-prone MRL/lpr strain of miceK Nakatani
First Department of Internal Medicine, Nara Medical University, Kashihara, Japan
Scand J Immunol 66:654-61. 2007..Fas(lpr) (MRL/lpr) strain of mice. This abnormality was characterized by the regression of B lymphopoiesis in the bone marrow of this strain...
- In vitro requirement for periostin in B lymphopoiesisBasile T Siewe
Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, 2160 S First Ave, Maywood, IL 60153, USA
Blood 117:3770-9. 2011B lymphopoiesis arrests in rabbits by 4 months of age...
- Selective role of calcineurin in haematopoiesis and lymphopoiesisElena M Gallo
Multidisciplinary Program in Immunology, Stanford University, Stanford, California, USA
EMBO Rep 9:1141-8. 2008..The requirement for calcineurin/NFAT in the development of the adaptive but not of the innate immune system is consistent with the idea that the evolutionary appearance of this pathway was involved in the emergence of vertebrates...
- Role of thymic organ structure and stromal composition in steady-state postnatal T-cell productionHoward T Petrie
Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Immunol Rev 189:8-19. 2002....
- Oestrogen receptor specificity in oestradiol-mediated effects on B lymphopoiesis and immunoglobulin production in male miceM C Erlandsson
Department of Rheumatology and Inflammation Research, Department of Internal Medicine, Goteborg University, Guldhedsgatan 10A, S 413 46 Goteborg, Sweden
Immunology 108:346-51. 2003Oestrogen treatment down-regulates B lymphopoiesis in the bone marrow of mice. Meanwhile it up-regulates immunoglobulin production...
- Lack of nuclear factor-kappa B2/p100 causes a RelB-dependent block in early B lymphopoiesisFeng Guo
Research Group Immunology, Leibniz Institute for Age Research Fritz Lipmann Institute, Jena, Germany
Blood 112:551-9. 2008..progenitors restored early B-cell development in p100(-/-) bone marrow, suggesting that impaired early B lymphopoiesis in mice lacking the p100 inhibitor may be due to down-regulation of Pax5 expression...
- [Effects of electroacupuncture on T-lymphocytes, spleen index, thymus index and lymphopoiesis levels in strenuous exercise-induced stress rats]Yong Mei Lu
College of Nursing, Guangzhou University of Chinese Medicine, Guangzhoug 510405, China
Zhen Ci Yan Jiu 37:136-9. 2012To observe the effect of electroacupuncture (EA) on levels of T-lymphocytes, spleen index, thymus index and lymphopoiesis in strenuous exercise-induced immunosuppression rats, so as to study its mechanisms underlying improving immune ..
- Wnt signaling in lymphopoiesisA Timm
Gene Center and Institute of Biochemistry, University of Munich, Germany
Curr Top Microbiol Immunol 290:225-52. 2005..and gain-of-function experiments in the mouse have provided insight into the role of this signaling pathway in lymphopoiesis. The self-renewal and maintenance of hematopoietic stem cells is regulated by Wnt signals...
- Chronic zinc deficiency in mice disrupted T cell lymphopoiesis and erythropoiesis while B cell lymphopoiesis and myelopoiesis were maintainedLouis E King
Department of Biochemistry and Molecular Biology, Room 419, Michigan State University, East Lansing, MI 48824 1319, USA
J Am Coll Nutr 24:494-502. 2005The purpose of this study was to determine the impact of chronic zinc deficiency (ChrZD) on T and B cell lymphopoiesis, myelopoiesis and erythropoiesis in mice.
- Withdrawal of sex steroids reverses age- and chemotherapy-related defects in bone marrow lymphopoiesisJarrod A Dudakov
Immune Regeneration Laboratory, Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Australia
J Immunol 182:6247-60. 2009..T cell production, there are also significant declines in B cell development and the progenitors that support lymphopoiesis. These collectively lead to a reduced peripheral immune repertoire, increase in opportunistic infections, and ..
- IL-7: a key regulator of B lymphopoiesisCraig D Milne
Ontario Cancer Institute, University Health Network, Department of Immunology, University of Toronto, Toronto, Ontario, Canada
Semin Immunol 18:20-30. 2006..Because of its central role in adult murine B lymphopoiesis, IL-7 is frequently used to generate B cell progenitors in vitro...
- Hoxb3 deficiency impairs B lymphopoiesis in mouse bone marrowKing Hung Ko
Department of Pathology and Center of Infection and Immunology, The University of Hong Kong, Hong Kong, China
Exp Hematol 35:465-75. 2007..Hox genes are involved in hematopoietic lineage commitment and differentiation. In this study, we investigated the roles of Hoxb3 in hematopoiesis by examining the phenotypes of a Hoxb3 knockout mutant mouse line...
- Premature replacement of mu with alpha immunoglobulin chains impairs lymphopoiesis and mucosal homing but promotes plasma cell maturationSophie Duchez
Laboratoire d Immunologie, Universite de Limoges, Centre National de la Recherche Scientifique Unité Mixte 6101, F 87025 Limoges, France
Proc Natl Acad Sci U S A 107:3064-9. 2010..Our data indicate that the IgM BCR is more efficient in driving early B cell education and in mucosal site targeting, whereas the IgA BCR appears particularly suited to promoting activation and differentiation of effector plasma cells...
- B cell-specific transgenic expression of Bcl2 rescues early B lymphopoiesis but not B cell responses in BOB.1/OBF.1-deficient miceCornelia Brunner
Department of Physiological Chemistry, University of Ulm, D 89081 Ulm, Germany
J Exp Med 197:1205-11. 2003..Virtually no functional MZ B cells were detected in these mice. In contrast, mice deficient for Bcl2 show a relative increase in MZ B cell numbers, indicating a previously undetected function of Bcl2 for this B cell compartment...
- T. brucei infection reduces B lymphopoiesis in bone marrow and truncates compensatory splenic lymphopoiesis through transitional B-cell apoptosisViki Bockstal
Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, Massachusetts, United States of America
PLoS Pathog 7:e1002089. 2011..In the spleen, T. brucei induces extramedullary B lymphopoiesis as evidenced by significant increases in HSC-LMPP, CLP, pre-pro-B, pro-B and pre-B cell populations...
- B lymphopoiesis is characterized by pre-B cell marker gene expression in fetal cattle and declines in adultsAnna Ekman
Department of Veterinary Biosciences, University of Helsinki, P O Box 66, 00014 Helsinki, Finland
Dev Comp Immunol 37:39-49. 2012..lack of B-lymphoid differentiation in adult bone marrow - OP9 stromal cell co-culture, suggest a decline of B lymphopoiesis in adult cattle...
- Wnt expression and canonical Wnt signaling in human bone marrow B lymphopoiesisGuri Døsen
Department of Immunology, Institute for Cancer Research, Rikshospitalet Radiumhospitalet Medical Center, Medical Faculty, University of Oslo, Norway
BMC Immunol 7:13. 2006The early B lymphopoiesis in mammals is regulated through close interactions with stromal cells and components of the intracellular matrix in the bone marrow (BM) microenvironment...
- Distinct changes in adult lymphopoiesis in Rag2-/- mice fully reconstituted by alpha4-deficient adult bone marrow cellsEna R Banerjee
Department of Medicine, Division of Hematology, University of Washington, Seattle, WA 98195 7710, USA
Exp Hematol 36:1004-13. 2008....
- At the crossroads: diverse roles of early thymocyte transcriptional regulatorsMichele K Anderson
Sunnybrook and Women s College Health Sciences Center, Division of Molecular and Cell Biology, University of Toronto, Department of Immunology, Toronto, ON, Canada
Immunol Rev 209:191-211. 2006....
- Spontaneous class switch recombination in B cell lymphopoiesis generates aberrant switch junctions and is increased after VDJ rearrangementEfrat Edry
Department of Immunology, Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
J Immunol 179:6555-60. 2007..Recently, we have shown that CSR spontaneously occur in B lymphopoiesis. However, the mechanism and regulation of it have not been defined...
- Linking age-related defects in B lymphopoiesis to the aging of hematopoietic stem cellsJuli P Miller
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 269 John Morgan Building, 36th and Hamilton Walk, Philadelphia, PA 19104, USA
Semin Immunol 17:321-9. 2005....
- BMP-6 inhibits human bone marrow B lymphopoiesis--upregulation of Id1 and Id3Christian Kersten
Department of Immunology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway
Exp Hematol 34:72-81. 2006..Bone morphogenetic proteins (BMPs) are multifunctional cytokines previously found to regulate hematopoietic stem cells. In the present study, we have explored the role of BMP-6 in human B progenitor cells...
- Pluripotent stem cell-derived HSCs: improvements and molecular mechanismsPatrick Cahan; Fiscal Year: 2013..Aim 2 will assess the contribution of Notch signaling to deficient lymphopoiesis in Hoxb4-induced PSC-HSCs. The five-year training program has been designed to establish Dr...
- B Cell Development in AgingJohn C Cambier; Fiscal Year: 2010..Thus, decreased B lymphopoiesis may be causal in the aging- associated decline in humoral immunity to newly encountered pathogens...
- Live cell imaging of IgH and c-Myc gene loci and the role of nuclear organizationMark T Groudine; Fiscal Year: 2010..Further, the distance between the IgH and c-Myc loci will be measured through lymphopoiesis and used to determine if the distance between the two loci prior to B cell stimulation influences the ..
- Role of the developmental regulator Gon4-like in B lymphopoiesisJOHN D COLGAN; Fiscal Year: 2011..Further, the knowledge gained will provide new insights regarding the fundamental processes that contribute to immune dysfunction or the development of lymphoid cancers. ..
- Environmental PPAR Agonists Accelerate Aging of Bone and Impair LymphopoiesisAMELIA RACHEL HAAS BAKER; Fiscal Year: 2013..1-500 nM). The bone marrow is a multifunctional organ that supports bone formation, as well as lymphopoiesis, and both functions are compromised during aging...
- Somatic Hypermutation in SLELawrence J Wysocki; Fiscal Year: 2013..genes and because of extensive somatic diversity generated by processes that assemble V region genes during B lymphopoiesis in the bone marrow and that mutate them in the periphery during immune responses...
- Role of the developmental regulator Gon4-like in B lymphopoiesisJOHN D COLGAN; Fiscal Year: 2013..Such knowledge will provide novel insights regarding the relationships between impairment of B cell development and the appearance of immunodeficiencies or B cell progenitor-derived lymphoid cancers. ..
- Pax5:Hematopoietic Transcription Factor Involved in ALLHAROLD PHILLIP KOEFFLER; Fiscal Year: 2013..First, we will determine if expression of PAX5 fusion proteins disrupts normal steady-state lymphopoiesis or hematopoiesis by impairing differentiation, promoting survival and/or proliferation of specific ..
- Regulation of cyclin D3 in B lymphocyte developmentMarcus R Clark; Fiscal Year: 2013..Early in B lymphopoiesis, Igm assembles with surrogate light chain and Iga/Igb to form a pre-BCR that first expands pre-B cell ..
- B-Cell Tolerance Mechanisms in Human SLEJENNIFER HOWITT ANOLIK; Fiscal Year: 2013..that a key dysregulated signal is interferon (IFN), with local production in the BM inhibiting BM B cell lymphopoiesis. On the other hand, we have found that a subset of SLE patients treated with BCDT experience restoration of B ..
- HOW ENVIRONMENTAL CHEMICALS IMPAIR IMMUNITYDavid Sherr; Fiscal Year: 2009..We demonstrated that PAH suppress B lymphopoiesis by inducing pro-B and pre-B cell apoptosis mediated indirectly through stromal cells constituting the ..
- Maintaining B cell immunity with aged B lymphocytesKatherine L Knight; Fiscal Year: 2013..Rabbits provide a useful model for studying the decline in B lymphopoiesis because it declines precipitously a few weeks after birth, and by 2 to 4 months of age, little or no B ..
- Molecular basis for age-related thymic involution and rejuvenationDong Ming Su; Fiscal Year: 2013..We will test the hypothesis that Foxn1-controlled TECs mediate critical changes of thymic aging, including T-lymphopoiesis and prevention of autoimmunity. To test this hypothesis, we propose four specific aims...
- Lymphoid signals for stromal growth and organization in the thymus.Howard T Petrie; Fiscal Year: 2012..The thymus is the primary site of de novo T lymphopoiesis. Microenvironmental conditions unique to the thymus induce a complex series of developmental events in ..
- Stromal catalase deficiency as the causative factor in accelerated thymic atrophyHoward T Petrie; Fiscal Year: 2013..The thymus is the primary site of T lymphopoiesis. However, the thymus is characterized by an accelerated, age-related atrophy, leading to a progressive decline ..
- Role of B-cell oncogenes and microRNA-34 in B-lymphopoiesis and neoplasiaDinesh S Rao; Fiscal Year: 2013..Hence, these studies have a direct relevance to public health and most importantly, to patients living with these diseases. ..
- HSC Diversity: Regulation by Clonal Selection vs Epigenetic InductionIrving L Weissman; Fiscal Year: 2013..we demonstrated a skewing in blood cell lineage representation as mice and humans age, from a balance between lymphopoiesis and myelomonocytopoiesis in young adult life, to a predominance of myelomonocytopoiesis in the elderly...
- Lymphopoietic development in the extra-embryonic yolk sacMervin C Yoder; Fiscal Year: 2013..Indeed, the most formidable obstacle encountered when attempting to define the onset of B lymphopoiesis in the developing murine embryo, is the onset of cardiac contractions and establishment of the circulation...
- Chaperone Mechanisms in Innate ImmunityZihai Li; Fiscal Year: 2013..can rescue the expression of both TLRs and integrins in gp96 KO murine cells;(iv) gp96 is critical for T and B lymphopoiesis but not myelopoiesis;(v) the folding of TLRs by gp96 is dependent on a substrate (TLR)-specific co-chaperone, ..
- Notch-induced protein degradation in lymphopoiesisXiao Hong Sun; Fiscal Year: 2013..There is good reason to believe the answers to these questions will lead to new treatments for several types of diseases. These include leukemias and cancers of the breast or intestine, autoimmune diseases and developmental defects. ..
- Human B1 LymphopoiesisThomas L Rothstein; Fiscal Year: 2013..To achieve this goal, several specific aims will be pursued to: 1) Establish a model system for lymphopoiesis that fosters the development of B1 cells from cord blood and/or bone marrow hematopoietic stem cells through ..
- Androgen Receptor in B Cell Development and FunctionsChawnshang Chang; Fiscal Year: 2010..of B cells in the bone marrow and peripheral blood, suggesting that AR plays a negative regulatory role in B lymphopoiesis. The overall objective of this proposal is to elucidate the mechanism through which AR regulates B ..
- Role of Extrinsic and Intrinsic Factors Responsible for Aging of Immune System Ian Rogers; Fiscal Year: 2013..population is detrimentally affected by aging as reflected by its inability to maintain both hematopoiesis and lymphopoiesis. Mice, the most common research model, although inexpensive, do not necessarily reflect the human immune ..
- IMMUNOBIOLOGY OF B CELL DIFFERENTIATIONKENNETH ALLAN DORSHKIND; Fiscal Year: 2013Project Description/Abstract Numerous studies have revealed differences in the transcriptional regulation of B lymphopoiesis in the embryo and the adult...
- Visualization and Lineage Tracing of Hematopoietic Stem Cell HeterogeneityBoris Reizis; Fiscal Year: 2013..The latter subset becomes predominant with age, limiting lymphopoiesis and predisposing to myeloproliferation...
- HETEROCHROMATIN RECRUITMENT OF THE VPAC1 LOCUS BY IKAROSGlenn Paul Dorsam; Fiscal Year: 2010..Ikaros is a master regulator of lymphopoiesis and sets the threshold for T cell activation...
- Stem Cell Therapies for Primary Immune DeficiencyGAY MIRIAM CROOKS; Fiscal Year: 2010..with SCID provides a unique biological and clinical setting to unravel mechanisms of stem cell engraftment, lymphopoiesis and immune reconstitution...
- Supplementation of cord blood transplants with limphoid progenitorsBritte C Beaudette Zlatanova; Fiscal Year: 2010..to support B cell development, we will explore whether adherent cells of the omentum, a site of fetal B lymphopoiesis, can provide an appropriate microenvironment for the expansion and differentiation of CB HSC...
- Extrathymic T cell precursors: commitment and efficacyHarald von Boehmer; Fiscal Year: 2012The nature of thymus immigrants that contribute most effectively to T lymphopoiesis is unknown even though several well-characterized progenitors have been described...
- Inflammasomes and the mechanism of thymic demise in agingVishwa Deep Dixit; Fiscal Year: 2013..canonical Nlrp3 Inflammasome dependent mechanism induces 'thymic inflammaging'and compromises thymic lymphopoiesis by impacting the integrity of thymic epithelial cells...
- The role of Ikaros in regulation of Notch target gene expressionSUSAN M WINANDY; Fiscal Year: 2010Ikaros is a nuclear protein and key regulator of T lymphopoiesis. Ikaros deficiency in mice results in abnormal T cell development and, with 100% penetrance, T cell leukemogenesis...
- Regulation of B Cell Development and Function by Zfp521JAMES R HAGMAN; Fiscal Year: 2013..Co-occupancy of Zfp521 and EBF1 on these genes suggests a new model for co-regulation of B lymphopoiesis. In this manner, EBF1, the B lineage determination factor, is regulated by Zfp521 in developing B cells...
- c-Myb controls survival, proliferation and differentiation during B-lymphopoiesisTimothy P Bender; Fiscal Year: 2013..The goal of this proposal is to develop the network of crucial genes that mediate c-Myb activity during different stages of B cell development. ..
- The Osteoblast as a Determinant of LeukemogenesisStavroula Kousteni; Fiscal Year: 2013..Concomitantly, B- lymphopoiesis is compromised...
- A Novel Hybrid Multifunctional Cytokine for Immune ReconstitutionSusan C Wright; Fiscal Year: 2012..on the known properties of IL-7, Ha7 is predicted promote immune reconstitution by stimulating T and B cell lymphopoiesis as well as homeostatic maintenance of mature T cells...
- Engineering hematopoietic progenitors for efficient migration to the thymusAvinash Bhandoola; Fiscal Year: 2010..the physiologically relevant progenitors that express these homing molecules and so contribute to T lymphopoiesis. We present data suggesting that the generation of thymic homing progenitors is deficient in aged mice...
- Identification and Functional Analysis of Novel Determiners of B LymphopoiesisKEITH MICHAEL HAMEL; Fiscal Year: 2013..Discrete stages of proliferation and differentiation of B lymphopoiesis are regulated by the coordinate expression of lineage and stage specific genes...
- GATA3 deregulation and T cell transformation in E2A-/- miceBARBARA LYNNE KEE; Fiscal Year: 2012DESCRIPTION (provided by applicant): GATA3 is an essential transcription factor for T lymphopoiesis but elevated expression of GATA3 can derail T cell differentiation and promote transformation...
- TCF/Lef Signaling in LymphopoiesisKristine Germar; Fiscal Year: 2010..Defects in these signaling cascades are likely to contribute to developmental diseases and leukemic transformation. Understanding these molecular processes will help design diagnostic tests and targeted therapies for these diseases ..
- Myc-directed control of mRNA turnover in lymphopoiesis and lymphomagenesisJohn L Cleveland; Fiscal Year: 2013..We submit the proposed studies will identify new targets that play key roles in lymphopoiesis and that can be exploited for the development of new anti-lymphoma drugs that are likely to have activity ..
- Selection of B cell repertoire in senescenceRichard L Riley; Fiscal Year: 2013DESCRIPTION (provided by applicant): B lymphopoiesis is severely compromised in murine senescence...
- Defining the Earliest Stages of Lymphoid Commitment in Human Bone MarrowLISA ANN KOHN; Fiscal Year: 2012..provided by applicant): A large number of reports continue to refine the differentiation stages of murine lymphopoiesis. However very little is known about the earliest stages of human lymphoid differentiation, those few reports ..
- Aging-associated alterations in adaptive landscapes and the evolution of leukemiaJames V DeGregori; Fiscal Year: 2013..oncogenic adaptation and leukemogenesis, and 3) dissect the molecular mechanisms underlying impaired B-lymphopoiesis and increased selection for particular oncogenes in old age...
- The effect of niche-specific cxcl12 production on B lymphopoiesis.RYAN BRENT DAY; Fiscal Year: 2013..applicant): The objective of this research is to define the role of niche-specific production of CXCL12 in B lymphopoiesis. In response to infection, there is a dramatic increase in neutrophil production (granulopoiesis) in the bone ..
- Skeletal development and the hematopoietic nicheOlena Jacenko; Fiscal Year: 2013..defects including altered hypertrophic cartilage and trabecular bone in the COJ, marrow hypoplasia, diminished lymphopoiesis, and impaired immune function...
- THYMUS 2012 INTERNATIONAL CONFERENCEJanko Nikolich-Zugich; Fiscal Year: 2012DESCRIPTION (provided by applicant): The ThymUS 2012 International Conference on Lymphopoiesis, T cell Differentiation and Immune Reconstitution will be held in Sunny Isles Beach, FL, from Nov 4-9. 2012...
- lymphostromal interactions in the thymic agingDong Ming Su; Fiscal Year: 2010Aging causes thymic involution which decreases thymic lymphopoiesis and exhausts the naive T-cell pool, constricting diversity of T-cell receptor repertoire and inducing immunosenescence...
- GATA3 regulation in transcriptional networks during hematopoietic cell developmenJames Douglas Engel; Fiscal Year: 2013..Thus GATA-3 is required at the earliest stage of T lymphopoiesis as well as at intermediate and late stages of thymocyte development and for CD4+ T cell Th2 differentiation in ..
- TSLP receptor in the regulation of cell developmentSteven F Ziegler; Fiscal Year: 2010..immune system, which includes the proper expression and function of cytokines and their cognate receptors, hi lymphopoiesis, interleukin (IL)-7 has been shown to be a critical component of both T and B cell development...
- PLC?s in B cell biology and autoimmunityDemin Wang; Fiscal Year: 2012..and PLC32 genes, we are well-positioned to further study the individual and combined roles of PLC31/PLC32 in B lymphopoiesis, including tolerance establishment, and the mechanism by which both PLC3s regulate the process...
- Ikaros regulation: study on hemo-lymphopoiesisKatia Georgopoulos; Fiscal Year: 2013..Exploitation of the Ikaros gene targets or their transcriptional and epigenetic mechanisms of regulation may empower the design of new intelligent/tailored diagnostics and therapies for high-risk B-ALL. . ..
- Trypanosoma brucei-induced dyshematopoiesis: blocked B lymphopoiesisSamuel Black; Fiscal Year: 2009..These observations lead us to hypothesize that T. brucei induces a reversible block in B lymphopoiesis that prevents replenishment of the pools of new and mature B cell, which leads to B- cell clonal exhaustion ..
- Migration of hematopoietic progenitors to the thymusAvinash Bhandoola; Fiscal Year: 2013..or inhibition of homing molecules will allow a broader range of blood progenitors to migrate to the thymus and improve T lymphopoiesis after bone marrow transplantation, and understand what the underlying mechanisms might be. !
- Early T lineage progenitorsAvinash Bhandoola; Fiscal Year: 2013..we think that more proliferation may occur immediately after thymic settling than at any subsequent stage of T lymphopoiesis. One goal of our current proposal is to quantify this proliferation, and to determine how it is regulated...
- IMMUNOBIOLOGY OF B CELL DIFFERENTIATIONKenneth Dorshkind; Fiscal Year: 1991..The Whitlock-Witte lymphoid bone marrow cultures (LBMC) allow long-term B lymphopoiesis. The MBMC B cell precursor can be induced to differentiate into B cells following switching to LBMC conditions...
- DIETARY ZINC-ITS EFFECTS ON THE IMMUNE RESPONSEPamela Fraker; Fiscal Year: 2007..Accelerated apoptosis disrupts lymphopoiesis creating lymphopenia, but splenic lymphocytes of the ZD mouse have greater potency...
- REGULATION OF HEMOPOIESIS BY STROMAL CELLSKenneth Dorshkind; Fiscal Year: 1993..studies have shown that CSFs stimulate myelopoiesis, but secondary effects on other lineages, particularly lymphopoiesis, have not been examined in detail...
- High-speed Flow CytometerKenneth Weinberg; Fiscal Year: 2003..development after hematopoietic stem cell transplantation (HSCT), and the function of cytokine receptors in lymphopoiesis. Again, these studies depend on combined antibody and EGFP-based assays as well as nucleic acid staining to ..
- B CELL REPERTOIRE OF NORMAL AND AUTOIMMUNE MICERichard Riley; Fiscal Year: 1992..B) Define whether the mechanisms responsible for defective B lymphopoiesis in NZ mice operate at the precursor cell level or upon the non-lymphoid stroma necessary for the support of B ..
- IL-7R and c-kit interactions in thymopoiesisKenneth Weinberg; Fiscal Year: 2006..of the c-kit or KL loci are well appreciated, the c-kit pathway can also significantly contribute to T lymphopoiesis. Mice with mutations of either KL or c-kit have defective thymopoiesis, which can be corrected by ..
- SCREEN FOR LYMPHOID MUTANTSNikolaus Trede; Fiscal Year: 2004During lymphopoiesis a pluripotent stem cell develops into T or B lymphocytes. The thymus provides a specialized environment for terminal T lymphocyte differentiation...
- Regulation of lymphocyte survival by NF-kB proteinsAmer Beg; Fiscal Year: 2004..1) We show here an impairment of lymphopoiesis following adoptive transfer of ReIA-/- fetal liver cells into irradiated lymphocyte-deficient Rag1-/- mice...
- MOLECULAR CONTROL OF ANTIGEN RECEPTOR GENE ASSEMBLYEugene Oltz; Fiscal Year: 2000..Proper targeting of these events is pivotal to lymphopoiesis; aberrations can produce chromosomal translocations that result in lymphoid tumors...
- Role of Plexin D1 in thymic developmentLinda Clayton; Fiscal Year: 2009..b>Lymphopoiesis of the T lineage in the thymus proceeds in a directional manner such that early double negative (DN) ..
- ROLE OF IL-7 IN DECREASED THYMOPOIESIS OF AGINGMarilyn Thoman; Fiscal Year: 2006..from Investigator's abstract) With advancing age the thymus undergoes involution resulting in reduced T lymphopoiesis. This decrease in T cell output from the thymus is thought to have a significant impact on the composition and ..
- Control of T Lymphopoiesis and Growth by Mad GenesBrian Iritani; Fiscal Year: 2007..abstract_text> ..