hematopoiesis

Summary

Summary: The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).

Top Publications

  1. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
  2. pmc Hematopoiesis: an evolving paradigm for stem cell biology
    Stuart H Orkin
    Division of Hematology Oncology, Children s Hospital Boston and the Dana Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 132:631-44. 2008
  3. pmc Densely interconnected transcriptional circuits control cell states in human hematopoiesis
    Noa Novershtern
    Broad Institute, Cambridge, MA 02142, USA
    Cell 144:296-309. 2011
  4. ncbi Humanized mice in translational biomedical research
    Leonard D Shultz
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Immunol 7:118-30. 2007
  5. ncbi MicroRNAs modulate hematopoietic lineage differentiation
    Chang Zheng Chen
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 303:83-6. 2004
  6. ncbi Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    F Shalaby
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 376:62-6. 1995
  7. ncbi Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment
    Benedetto Sacchetti
    Deparment of Experimental Medicine, La Sapienza University, 00161 Rome, Italy
    Cell 131:324-36. 2007
  8. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
  9. pmc Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation
    David A Hill
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Med 18:538-46. 2012
  10. pmc Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation
    Edward Owusu-Ansah
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA
    Nature 461:537-41. 2009

Research Grants

  1. THE ROLE OF ZINC FINGER GENES IN HEMATOPOIESIS
    Sinisa Dovat; Fiscal Year: 2003
  2. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
  3. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
  4. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
  5. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
  6. MECHANISMS OF EUKARYOTIC TRANSCRIPTIONAL REGULATION
    Michael R Green; Fiscal Year: 2013
  7. PEARLIE K BURNETTE; Fiscal Year: 2016
  8. In Vivo Function of TRAF6 As a Target of K63-Linked Polyubiquitination
    DEAN BALLARD; Fiscal Year: 2010
  9. Patrick Cahan; Fiscal Year: 2016
  10. J Evan Sadler; Fiscal Year: 2016

Detail Information

Publications431 found, 100 shown here

  1. ncbi SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    Mark J Kiel
    Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cell 121:1109-21. 2005
    ..Many HSCs were associated with sinusoidal endothelium in spleen and bone marrow, though some HSCs were associated with endosteum. HSCs thus occupy multiple niches, including sinusoidal endothelium in diverse tissues...
  2. pmc Hematopoiesis: an evolving paradigm for stem cell biology
    Stuart H Orkin
    Division of Hematology Oncology, Children s Hospital Boston and the Dana Farber Cancer Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 132:631-44. 2008
    ..Studies of hematopoiesis provide critical insights of general relevance to other areas of stem cell biology including the role of ..
  3. pmc Densely interconnected transcriptional circuits control cell states in human hematopoiesis
    Noa Novershtern
    Broad Institute, Cambridge, MA 02142, USA
    Cell 144:296-309. 2011
    ..factors are known to regulate hematopoietic differentiation, major aspects of the global architecture of hematopoiesis remain unknown...
  4. ncbi Humanized mice in translational biomedical research
    Leonard D Shultz
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Nat Rev Immunol 7:118-30. 2007
    ....
  5. ncbi MicroRNAs modulate hematopoietic lineage differentiation
    Chang Zheng Chen
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA
    Science 303:83-6. 2004
    ..expressed in hematopoietic cells and show that their expression is dynamically regulated during early hematopoiesis and lineage commitment...
  6. ncbi Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    F Shalaby
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Nature 376:62-6. 1995
    ..These results indicate that Flk-1 is essential for yolk-sac blood-island formation and vasculogenesis in the mouse embryo...
  7. ncbi Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment
    Benedetto Sacchetti
    Deparment of Experimental Medicine, La Sapienza University, 00161 Rome, Italy
    Cell 131:324-36. 2007
    ..Our data reveal the functional relationships between establishment of the HME in vivo, establishment of skeletal progenitors in BM sinusoids, and angiogenesis...
  8. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
    ..These results may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia...
  9. pmc Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation
    David A Hill
    Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Med 18:538-46. 2012
    ..Collectively, these results identify a previously unrecognized pathway through which commensal-derived signals influence basophil hematopoiesis and susceptibility to T(H)2 cytokine-dependent inflammation and allergic disease.
  10. pmc Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation
    Edward Owusu-Ansah
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California 90095, USA
    Nature 461:537-41. 2009
    ..Our results lead to a model that could be extended to reveal a probable signalling role for ROS in the differentiation of CMPs in mammalian haematopoietic development and oxidative stress response...
  11. doi Hematopoiesis: a human perspective
    Sergei Doulatov
    Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research Ontario Cancer Institute, Toronto, ON M5G 1L7, Canada
    Cell Stem Cell 10:120-36. 2012
    ....
  12. ncbi Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials
    Lu Lu Lü
    National Engineering Research Center of Cell Products, AmCellGene Co Ltd
    Haematologica 91:1017-26. 2006
    ..We isolated MSC from human full term umbilical cord tissues (UC). The biological characteristics of MSC derived from UC (UC-MSC) were further determined and compared with normal adult bone marrow-derived MSC (BM-MSC)...
  13. pmc The emerging role of MIR-146A in the control of hematopoiesis, immune function and cancer
    Catherine Labbaye
    Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    J Hematol Oncol 5:13. 2012
    ..focus on recent progress in analyzing the functional role of miR-146a in the control of normal and malignant hematopoiesis. On the other hand, this miRNA has shown to impact in the control of innate immune responses...
  14. doi Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation
    KEITH W ORFORD
    Massachusetts General Hospital, MGH Center for Regenerative Medicine, Harvard University, 185 Cambridge Street, CPZN Room 4265A, Boston, Massachusetts 02114, USA
    Nat Rev Genet 9:115-28. 2008
    ..Although the dynamics of the embryonic and adult stem cell cycles are profoundly dissimilar, we suggest that shared principles underlie the governance of this important decision point in diverse stem cell types...
  15. pmc Comprehensive methylome map of lineage commitment from haematopoietic progenitors
    Hong Ji
    Center for Epigenetics and Department of Medicine, Johns Hopkins University School of Medicine, 570 Rangos, 725 N Wolfe St, Baltimore, Maryland 21205, USA
    Nature 467:338-42. 2010
    ....
  16. pmc The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins
    I A Wadman
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 16:3145-57. 1997
    ..These data demonstrate one function for the LIM-binding protein Ldb1 and establish a function for the LIM-only protein Lmo2 as an obligatory component of an oligomeric, DNA-binding complex which may play a role in haematopoiesis...
  17. ncbi Hematopoietic stem cell quiescence maintained by p21cip1/waf1
    T Cheng
    Experimental Hematology, AIDS Research Center, Massachusetts General Hospital Cancer Center, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Science 287:1804-8. 2000
    ..Under conditions of stress, restricted cell cycling is crucial to prevent premature stem cell depletion and hematopoietic death...
  18. pmc Oxidative stress in the regulation of normal and neoplastic hematopoiesis
    Saghi Ghaffari
    Department of Gene and Cell Medicine, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Antioxid Redox Signal 10:1923-40. 2008
    ..These abnormalities may lead to accelerated aging of hematopoietic stem cells or to hematopoietic malignancies...
  19. pmc Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
    Emmanuelle Passegue
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 202:1599-611. 2005
    ..stem cells (HSC) is essential to understand their function in maintaining blood cell production during normal hematopoiesis and upon clinical transplantation...
  20. pmc Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow
    Satoru Morikawa
    Department of Physiology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    J Exp Med 206:2483-96. 2009
    ..Naive MSCs resided in the perivascular region in a quiescent state. This study provides the useful method needed to identify MSCs as defined in vivo entities...
  21. pmc Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
    Michael G Kharas
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Nat Med 16:903-8. 2010
    ....
  22. pmc Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration
    Eirini Trompouki
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Cell 147:577-89. 2011
    ..We conclude that the regenerative response mediated by BMP and Wnt signaling pathways is coupled with the lineage master regulators to control the gene programs defining cellular identity...
  23. ncbi AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis
    T Okuda
    Department of Pathology and Laboratory Medicine, St Jude Children s Research Hospital Memphis, Tennessee 38105, USA
    Cell 84:321-30. 1996
    ..mutations in AML1 showed normal morphogenesis and yolk sac-derived erythropoiesis, but lacked fetal liver hematopoiesis and died around E12.5...
  24. ncbi Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1
    Frank Rosenbauer
    Harvard Institutes of Medicine, Room 954, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Genet 36:624-30. 2004
    ..by analysis of gene-knockout mice, which uncovered crucial roles of several transcription factors in normal hematopoiesis, and of individuals with leukemia, in whom transcription factors are frequently downregulated or mutated...
  25. ncbi Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1
    T Nagasawa
    Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Japan
    Nature 382:635-8. 1996
    ..In addition, the mutants had a cardiac ventricular septal defect. Hence, we have shown that the chemokine PBSF/SDF-1 has several essential functions in development...
  26. ncbi Postembryonic hematopoiesis in Drosophila
    R Lanot
    UPR 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, Strasbourg Cedex, 67084, France
    Dev Biol 230:243-57. 2001
    ..The most dramatic effect on larval hematopoiesis was observed following infestation by a parasitoid wasp...
  27. pmc Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
    Olaia Naveiras
    Division of Pediatric Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Massachusetts 02115, USA
    Nature 460:259-63. 2009
    ..These data implicate adipocytes as predominantly negative regulators of the bone-marrow microenvironment, and indicate that antagonizing marrow adipogenesis may enhance haematopoietic recovery in clinical bone-marrow transplantation...
  28. doi p57 is required for quiescence and maintenance of adult hematopoietic stem cells
    Akinobu Matsumoto
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Fukuoka 812 8582, Japan
    Cell Stem Cell 9:262-71. 2011
    ..Our results therefore suggest that, among Cip/Kip family CDK inhibitors, p57 plays a predominant role in the quiescence and maintenance of adult HSCs...
  29. ncbi Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
    Keisuke Ito
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 431:997-1002. 2004
    ..These results show that the self-renewal capacity of HSCs depends on ATM-mediated inhibition of oxidative stress...
  30. pmc Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis
    Q Wang
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    Proc Natl Acad Sci U S A 93:3444-9. 1996
    ..Definitive erythropoiesis and myelopoiesis do not occur in Cbfa2-deficient embryos, and disruption of one copy of the Cbfa2 gene significantly reduces the number of progenitors for erythroid and myeloid cells...
  31. pmc A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
    Yoon Young Jang
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 110:3056-63. 2007
    ..The ROS-related signaling pathways together with specific characteristics of niche HSCs may serve as targets for beneficial therapies...
  32. doi Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion
    Tiago C Luis
    Department of Immunology, Erasmus University Medical Center, The Netherlands
    Cell Stem Cell 9:345-56. 2011
    Canonical Wnt signaling has been implicated in the regulation of hematopoiesis. By employing a Wnt-reporter mouse, we observed that Wnt signaling is differentially activated during hematopoiesis, suggesting an important regulatory role ..
  33. pmc Deregulation of microRNA involved in hematopoiesis and the immune response in HTLV-I adult T-cell leukemia
    Marcia Bellon
    University of Kansas Medical Center, Department of Pathology and Laboratory Medicine, Center for Viral Oncology and University of Kansas Cancer Center, Kansas City, 66160, USA
    Blood 113:4914-7. 2009
    ..MicroRNAs (miRNAs) are differentially expressed during hematopoiesis and lineage commitment of hematopoietic stem cell progenitors (HSCPs)...
  34. ncbi The roles of FLT3 in hematopoiesis and leukemia
    D Gary Gilliland
    Brigham and Women s Hospital, Howard Hughes Medical Institute, Boston, MA, USA
    Blood 100:1532-42. 2002
    ..Taken together, these results suggest that FLT3 is an attractive therapeutic target for kinase inhibitors or other approaches for patients with mutations of this gene...
  35. ncbi Human embryonic stem cell-derived CD34+ cells: efficient production in the coculture with OP9 stromal cells and analysis of lymphohematopoietic potential
    Maxim A Vodyanik
    Department of Pathology and Laboratory Medicine, Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53792 8550, USA
    Blood 105:617-26. 2005
    ..The hES cell-derived CD34+ cells were highly enriched in colony-forming cells, cells expressing hematopoiesis-associated genes GATA-1, GATA-2, SCL/TAL1, and Flk-1, and retained clonogenic potential after in vitro ..
  36. ncbi Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells
    H J McKenna
    Immunex Corporation, Seattle, WA 98101, USA
    Blood 95:3489-97. 2000
    ..fms-like tyrosine kinase 3 (flt3), also referred to as fetal liver kinase-2 (flk-2), has an important role in hematopoiesis. The flt3 ligand (flt3L) is a growth factor for hematopoietic progenitors and induces hematopoietic progenitor ..
  37. doi Modeling of asymmetric cell division in hematopoietic stem cells--regulation of self-renewal is essential for efficient repopulation
    Anna Marciniak-Czochra
    Interdisciplinary Center of Scientific Computing IWR, Institute of Applied Mathematics, University of Heidelberg, Heidelberg, Germany
    Stem Cells Dev 18:377-85. 2009
    ..The model is compatible with the increase of leukocyte numbers following HSC transplantation. This study demonstrates that extrinsic regulation of the self-renewal rate of HSC is most essential in the process of hematopoiesis.
  38. ncbi Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish
    Jennifer Rhodes
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Dev Cell 8:97-108. 2005
    The zebrafish is a powerful model system for investigating embryonic vertebrate hematopoiesis, allowing for the critical in vivo analysis of cell lineage determination...
  39. pmc Zebrafish as a model for normal and malignant hematopoiesis
    Lili Jing
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital Boston and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Dis Model Mech 4:433-8. 2011
    Zebrafish studies in the past two decades have made major contributions to our understanding of hematopoiesis and its associated disorders...
  40. ncbi An early haematopoietic defect in mice lacking the transcription factor GATA-2
    F Y Tsai
    Division of Hematology Oncology, Children s Hospital, Boston, Massachusetts
    Nature 371:221-6. 1994
    ..We propose that GATA-2 regulates genes controlling growth factor responsiveness or the proliferative capacity of early haematopoietic cells...
  41. pmc Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures
    Marion Kennedy
    Department of Gene and Cell Medicine, The Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York NY 10029, USA
    Blood 109:2679-87. 2007
    The onset of hematopoiesis in the mouse embryo and in the embryonic stem (ES) cell differentiation model is defined by the emergence of the hemangioblast, a progenitor with both hematopoietic and vascular potential...
  42. pmc Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells
    Andrea T Hooper
    Howard Hughes Medical Institute, Weill Cornell Medical College, New York, NY 10065, USA
    Cell Stem Cell 4:263-74. 2009
    ..contributes to engraftment of transplanted hematopoietic stem and progenitor cells (HSPCs) and restoration of hematopoiesis. We found that chemotherapy and sublethal irradiation induced minor regression of BM sinusoidal endothelial ..
  43. doi TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
    Cyril Quivoron
    INSERM, U, Villejuif, France
    Cancer Cell 20:25-38. 2011
    ..We report that inactivation of Tet2 in mouse perturbs both early and late steps of hematopoiesis including myeloid and lymphoid differentiation in a cell-autonomous manner, endows the cells with competitive ..
  44. doi Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment
    Faiyaz Notta
    Division of Stem Cell and Developmental Biology, Campbell Family Institute for Cancer Research Ontario Cancer Institute, Toronto, Ontario, Canada
    Science 333:218-21. 2011
    ..The demarcation of human HSCs and MPPs will enable the investigation of the molecular determinants of HSCs, with a goal of developing stem cell-based therapeutics...
  45. ncbi Leptin in the regulation of immunity, inflammation, and hematopoiesis
    G Fantuzzi
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    J Leukoc Biol 68:437-46. 2000
    ..Leptin also plays a regulatory role in immunity, inflammation, and hematopoiesis. Alterations in immune and inflammatory responses are present in leptin- or leptin-receptor-deficient animals, ..
  46. pmc Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7
    Frederic Sierro
    Department of Immunology and Inflammation, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Proc Natl Acad Sci U S A 104:14759-64. 2007
    ..Our results reveal a specialized role for CXCR7 in endothelial biology and valve development and highlight the distinct developmental role of evolutionary conserved chemokine receptors such as CXCR7 and CXCR4...
  47. pmc mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells
    Chong Chen
    1Division of Immunotherapy, Department of Surgery, University of Michigan School of Medicine and Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    Sci Signal 2:ra75. 2009
    ..In old mice, rapamycin increased life span, restored the self-renewal and hematopoiesis of HSCs, and enabled effective vaccination against a lethal challenge with influenza virus...
  48. pmc Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
    Marc H G P Raaijmakers
    Center for Regenerative Medicine, Massachusetts General Hospital and Harvard Medical School CPZN, USA
    Nature 464:852-7. 2010
    ..Furthermore, primary stromal dysfunction can result in secondary neoplastic disease, supporting the concept of niche-induced oncogenesis...
  49. ncbi Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin+ cells at a diverging point of endothelial and hemopoietic lineages
    S I Nishikawa
    Department of Molecular Genetics, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Development 125:1747-57. 1998
    ..This line of evidence implicates Flk1+VE-cadherin+ cells as a diverging point of hemopoietic and endothelial cell lineages...
  50. ncbi Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding
    C Porcher
    Division of Hematology and Oncology, Children s Hospital and Dana Farber Cancer Institute, Department of Pediatrics, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Development 126:4603-15. 1999
    ..Contrary to all expectation, we find that SCL variants unable to bind DNA rescue hematopoiesis from gene-targeted SCL(-)(/)(-) embryonic stem cells and complement hematopoietic and vascular deficits in the ..
  51. pmc Hematopoietic, angiogenic and eye defects in Meis1 mutant animals
    Tomoyuki Hisa
    Center for Cancer Research, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA
    EMBO J 23:450-9. 2004
    ..These and other studies showing that Meis1 is expressed at high levels in hematopoietic stem cells (HSCs) suggest that Meis1 may also be required for the proliferation/self-renewal of the HSC...
  52. ncbi Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells
    Ann C M Brun
    Department of Molecular Medicine and Gene Therapy, Institute of Laboratory Medicine, Lund Strategic Center for Stem Cell Biology and Cell Therapy, Lund University Hospital, BMC A12, 221 84 Lund, Sweden
    Blood 103:4126-33. 2004
    ..Therefore, we asked what physiologic role Hoxb4 has in hematopoiesis. A novel mouse model lacking the entire Hoxb4 gene exhibits significantly reduced cellularity in spleen and ..
  53. ncbi Cell-mediated immunity in arthropods: hematopoiesis, coagulation, melanization and opsonization
    Pikul Jiravanichpaisal
    Department of Comparative Physiology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18A, 752 36 Uppsala, Sweden
    Immunobiology 211:213-36. 2006
    ..Also the ways in which hemocytes are produced in and released from hematopoietic tissue are discussed...
  54. pmc Fate tracing reveals the endothelial origin of hematopoietic stem cells
    Ann C Zovein
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Cell Stem Cell 3:625-36. 2008
    ..Moreover, AGM mesenchyme, as selectively traced via a myocardin Cre line, is incapable of hematopoiesis. Our genetic tracing strategy therefore reveals an endothelial origin of HSCs.
  55. pmc Hematopoietic stem cell development is dependent on blood flow
    Trista E North
    Stem Cell Program and Hematology Oncology, Children s Hospital, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 137:736-48. 2009
    ..This work links blood flow to AGM hematopoiesis and identifies NO as a conserved downstream regulator of HSC development.
  56. pmc Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
    Boyi Gan
    Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 468:701-4. 2010
    ..Thus, Lkb1 serves as an essential regulator of HSCs and haematopoiesis, and more generally, points to the critical importance of coupling energy metabolism and stem-cell homeostasis...
  57. doi Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression
    Giuseppe Zardo
    San Raffaele Bio medical Park Foundation, Rome, Italy
    Blood 119:4034-46. 2012
    ....
  58. pmc Oncomir miR-125b regulates hematopoiesis by targeting the gene Lin28A
    Aadel A Chaudhuri
    Departments of Biology and Computing and Mathematical Sciences, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 109:4233-8. 2012
    ..Investigating the mechanism by which miR-125b regulates hematopoiesis, we found that, among a panel of candidate targets, the mRNA for Lin28A, an induced pluripotent stem cell gene,..
  59. pmc Essential role of c-myb in definitive hematopoiesis is evolutionarily conserved
    Cristian Soza-Ried
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Proc Natl Acad Sci U S A 107:17304-8. 2010
    The transcription factor c-myb has emerged as one of the key regulators of vertebrate hematopoiesis. In mice, it is dispensable for primitive stages of blood cell development but essentially required for definitive hematopoiesis...
  60. ncbi Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia
    S Mizuno
    First Department of Internal Medicine, Kyushu University, Fukuoka, Japan
    Blood 97:1172-9. 2001
    ..chain reaction (PCR) assays were performed and the expression levels of DNMTs were measured in normal hematopoiesis, 33 cases of acute myelogenous leukemia (AML), and 17 cases of chronic myelogenous leukemia (CML)...
  61. pmc Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
    Emmanuelle Passegue
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 100:11842-9. 2003
    ..Moreover, LSC identification and purification will provide a powerful diagnostic, prognostic, and therapeutic tool in the clinic...
  62. pmc Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells
    Hui Zeng
    Institut für Zellbiologie Tumorforschung, IFZ, Universitatsklinikum Essen, Essen, Germany
    EMBO J 23:4116-25. 2004
    ....
  63. pmc Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
    S R McKercher
    Burnham Institute, La Jolla, CA, USA
    EMBO J 15:5647-58. 1996
    ..While the PU.1 protein appears not to be essential for myeloid and lymphoid lineage commitment, it is absolutely required for the normal differentiation of B cells and macrophages...
  64. ncbi WNT signalling and haematopoiesis: a WNT-WNT situation
    Frank J T Staal
    Department of Immunology, Room Ee 838, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
    Nat Rev Immunol 5:21-30. 2005
    ....
  65. ncbi Age-related changes in lymphocyte development and function
    Phyllis Jean Linton
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    Nat Immunol 5:133-9. 2004
    ..This review aims to provide an overview of age-related changes in lymphocyte development and function and discusses current controversies in the field of aging research...
  66. pmc A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway
    Dónal O'Carroll
    The Laboratory for Lymphocyte Signaling, The Rockefeller University, New York, New York 10021, USA
    Genes Dev 21:1999-2004. 2007
    ..Both of these functions are executed by Argonaute 2 (Ago2). Using hematopoiesis in mice as a model system to study the physiological function of Ago2 in vivo, we found that Ago2 controls ..
  67. ncbi PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis
    Gang Huang
    Hematology Oncology Division, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 40:51-60. 2008
    ..1 expression rescued or partially rescued each phenotype. Thus, our data demonstrate that PU.1 is a major downstream target gene of AML1...
  68. pmc Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder
    Ryan M O'Connell
    Department of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    J Exp Med 205:585-94. 2008
    ....
  69. doi The Ikaros gene family: transcriptional regulators of hematopoiesis and immunity
    Liza B John
    School of Medicine, Deakin University, Waurn Ponds, Victoria 3217, Australia
    Mol Immunol 48:1272-8. 2011
    ..In this way, Ikaros family members regulate important cell-fate decisions during hematopoiesis, particularly in the development of the adaptive immune system...
  70. ncbi Blood-forming potential of vascular endothelium in the human embryo
    Estelle Oberlin
    INSERM Unité 506, Villejuif, France
    Development 129:4147-57. 2002
    ..from the yolk sac and aorta and cultured in the presence of stromal cells that support human multilineage hematopoiesis. Embryonic endothelial cells were most accurately selected on CD34 or CD31 surface expression and absence of ..
  71. doi Embryonic origin of the adult hematopoietic system: advances and questions
    Alexander Medvinsky
    MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, University of Edinburgh, Edinburgh EH9 3JQ, UK
    Development 138:1017-31. 2011
    ....
  72. ncbi Hematopoiesis is severely altered in mice with an induced osteoblast deficiency
    Dora Visnjic
    Department of Genetics and Developmental Biolgoy, University of Connecticut Health Center, Farmington, CT 06030, USA
    Blood 103:3258-64. 2004
    ..Together with the decrease in bone marrow hematopoiesis, active extramedullary hematopoiesis was observed in the spleen and liver, as measured by an increase in ..
  73. ncbi Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis
    Ute Koch
    Swiss Institute for Experimental Cancer Research ISREC, Ecole Polytechnique Federale de Lausanne EPFL, Epalinges, Switzerland
    Blood 111:160-4. 2008
    Hematopietic stem cells (HSCs) maintain life-long hematopoiesis in the bone marrow via their ability to self-renew and to differentiate into all blood lineages...
  74. ncbi Hox genes in hematopoiesis and leukemogenesis
    B Argiropoulos
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada
    Oncogene 26:6766-76. 2007
    ..model have provided strong correlative evidence for the involvement of clustered Hox genes in normal hematopoiesis. The data strongly support the hypothesis that the role of Hox genes in normal hematopoiesis is primarily at ..
  75. doi The earliest thymic progenitors for T cells possess myeloid lineage potential
    J Jeremiah Bell
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 452:764-7. 2008
    ..Our results indicate that alternative models for lineage commitment during haematopoiesis must be considered...
  76. doi The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development
    Nicola K Wilson
    University of Cambridge, Department of Haematology, Cambridge Institute for Medical Research, Cambridge, United Kingdom
    Blood 113:5456-65. 2009
    ....
  77. doi Zebrafish as a model for vertebrate hematopoiesis
    Felix Ellett
    Cancer and Haematology Division, The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia
    Curr Opin Pharmacol 10:563-70. 2010
    ..A standout example of the utility of this model has been its application to modeling of the earliest stages of hematopoiesis. Zebrafish developmental hematopoiesis shows close correspondence to the development of the mammalian ..
  78. ncbi Differentiation of human embryonic stem cells in serum-free medium reveals distinct roles for bone morphogenetic protein 4, vascular endothelial growth factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis
    Marjorie Pick
    Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria 3800, Australia
    Stem Cells 25:2206-14. 2007
    ..These data demonstrate the utility of the serum-free spin EB system in dissecting the roles of specific growth factors required for the directed differentiation of HESCs toward the hematopoietic lineage...
  79. ncbi The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
    S J Morrison
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Immunity 1:661-73. 1994
    ..The ability to predict the longevity of reconstitution based on lineage marker expression indicates that reconstitution potential is deterministic, not stochastic...
  80. ncbi Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha
    Pu Zhang
    Harvard Institutes of Medicine, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 21:853-63. 2004
    ..Therefore, C/EBP alpha is not only essential for granulocyte development but, in addition, is a regulator of hematopoietic stem cell activity...
  81. pmc Hematopoietic stem cell fate is established by the Notch-Runx pathway
    Caroline Erter Burns
    Stem Cell Program and Division of Hematology Oncology Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:2331-42. 2005
    ..The Notch signaling mutant mind bomb displays normal embryonic hematopoiesis but fails to specify adult HSCs...
  82. ncbi Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block
    Peggy Kirstetter
    European Molecular Biology Laboratory Mouse Biology Unit, 00016 Monterotondo, Italy
    Nat Immunol 7:1048-56. 2006
    ..is activated in both myeloid and lymphoid malignancies, indicating involvement in both normal and malignant hematopoiesis. We report here activated canonical Wnt signaling in the hematopoietic system through conditional expression ..
  83. ncbi Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    F Kontgen
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Genes Dev 9:1965-77. 1995
    ..The ability of exogenous interleukin-2 to restore T Cell, but not B cell, proliferation indicates that Rel regulates the expression of different genes in B and T cells that are crucial for cell division and immune function...
  84. pmc Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells
    J L Christensen
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 98:14541-6. 2001
    ..Fetal liver HSCs are contained within Flk-2(-) and Flk-2(+) KTLS cells...
  85. ncbi Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway
    Wei He
    Cancer Biology and Genetics Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cell 125:929-41. 2006
    ..Thus, Smad2/3-TIF1gamma and Smad2/3-Smad4 function as complementary effector arms in the control of hematopoietic cell fate by the TGFbeta/Smad pathway...
  86. ncbi Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner
    M Majka
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Blood 97:3075-85. 2001
    The aim of this study was to explore further the hypothesis that early stages of normal human hematopoiesis might be coregulated by autocrine/paracrine regulatory loops and by cross-talk among early hematopoietic cells...
  87. ncbi Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2T1 transgene advances a model for studies of leukemogenesis
    Maggie L Kalev-Zylinska
    Division of Molecular Medicine, The University of Auckland, Auckland, New Zealand
    Development 129:2015-30. 2002
    RUNX1/AML1/CBFA2 is essential for definitive hematopoiesis, and chromosomal translocations affecting RUNX1 are frequently involved in human leukemias...
  88. doi A compendium of genome-wide hematopoietic transcription factor maps supports the identification of gene regulatory control mechanisms
    Rebecca Hannah
    University of Cambridge, Department of Haematology, Cambridge Institute for Medical Research, Hills Road, Cambridge, UK
    Exp Hematol 39:531-41. 2011
    ..mechanisms therefore holds great promise in advancing our understanding of both normal and malignant hematopoiesis. Recent technological advances have enabled the generation of genome-wide transcription factor binding maps ..
  89. pmc Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development
    T C Luis
    Department of Immunology, Erasmus MC, Erasmus University Medical Center, Rotterdam, The Netherlands
    Leukemia 26:414-21. 2012
    ..animal models have produced contradictory findings regarding the importance of Wnt signals for normal hematopoiesis and lymphopoiesis...
  90. ncbi Stem cell factor and hematopoiesis
    V C Broudy
    Department of Medicine, University of Washington, Seattle 98195 7710, USA
    Blood 90:1345-64. 1997
  91. ncbi Cbfa2 is required for the formation of intra-aortic hematopoietic clusters
    T North
    Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA
    Development 126:2563-75. 1999
    ..Cbfa2 appears to be required for maintenance of Cbfa2 expression in the endothelium, and for the formation of intra-aortic hematopoietic clusters from the endothelium...
  92. ncbi Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
    G Bhardwaj
    John P Robarts Research Institute, Developmental Stem Cell Biology, 100 Perth Drive, London, Ontario N6A 5K8, Canada
    Nat Immunol 2:172-80. 2001
    A pool of stem cells that arise from the mesoderm during embryogenesis initiates hematopoiesis. However, factors that regulate the expansion of blood stem cells are poorly understood...
  93. pmc GATA-2 functions downstream of BMPs and CaM KIV in ectodermal cells during primitive hematopoiesis
    Gokhan Dalgin
    Department of Cell and Developmental Biology, Oregon Health and Science University, School of Medicine, Portland, OR 97239 3098, USA
    Dev Biol 310:454-69. 2007
    ..Our data support a model in which Gata-2 is a transcriptional target downstream of BMPs within ectodermal cells, while activation of the CaM KIV signaling pathway alters GATA-2 function posttranslationally, by inhibiting its acetylation...
  94. doi Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation
    Tiago C Luis
    Department of Immunology, ErasmusMC, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 113:546-54. 2009
    Canonical Wnt signaling has been implicated in various aspects of hematopoiesis. Its role is controversial due to different outcomes between various inducible Wnt-signaling loss-of-function models and also compared with gain-of-function ..
  95. doi Zebrafish blood stem cells
    Aye T Chen
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biochem 108:35-42. 2009
    ..All vertebrates including zebrafish have primitive and definitive waves of hematopoiesis, but self-renewing pluripotent HSCs are only produced by the definitive wave...
  96. pmc Rho GTPases in hematopoiesis and hemopathies
    James C Mulloy
    Division of Experimental Hematology and Cancer Biology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, OH 45229, USA
    Blood 115:936-47. 2010
    ..In this review we discuss recent genetic studies of Rho GTPases in hematopoiesis and several blood lineages and the implications of Rho GTPase signaling in hematologic malignancies, immune ..
  97. pmc Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation
    Stephanie Y Jo
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Blood 117:4759-68. 2011
    ..of constitutive Dot1l knockout mice show that Dot1l is essential for embryonic development and prenatal hematopoiesis. DOT1L also interacts with translocation partners of Mixed Lineage Leukemia (MLL) gene, which is commonly ..
  98. ncbi The 'definitive' (and 'primitive') guide to zebrafish hematopoiesis
    Alan J Davidson
    Division of Hematology Oncology, Department of Medicine, Children s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA
    Oncogene 23:7233-46. 2004
    ..extensive evolutionary divergence between bony fish (teleosts) and mammals, the molecular pathways governing hematopoiesis have been highly conserved...
  99. pmc Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells
    Xi Ren
    Key Laboratory of Cell Proliferation and Differentiation, Center of Developmental Biology and Genetics, College of Life Sciences, Peking University, Ministry of Education, China
    Blood 115:5338-46. 2010
    ..is essential for vascular endothelial development, also plays a critical role in the initiation of definitive hematopoiesis by controlling the expression of 2 stem cell leukemia (scl) isoforms (scl-alpha and scl-beta) in angioblasts...
  100. ncbi Hematopoietic cytokines, transcription factors and lineage commitment
    Jiang Zhu
    Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, PA 19104, USA
    Oncogene 21:3295-313. 2002
    ..witnessed significant advances in our understanding of the cellular physiology and molecular regulation of hematopoiesis. At the heart of stem cell self-renewal and lineage commitment decisions lies the relative expression levels ..
  101. ncbi Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre
    Joanna Krzemien
    Centre de Biologie du Developpement, UMR 5547 and IFR 109, CNRS and Université Paul Sabatier, Toulouse III, 118 route de Narbonne, 31062 Toulouse Cedex 09, France
    Nature 446:325-8. 2007
    ....

Research Grants79

  1. THE ROLE OF ZINC FINGER GENES IN HEMATOPOIESIS
    Sinisa Dovat; Fiscal Year: 2003
    The objective of the proposed study is to understand the normal hematopoiesis and malignant transformation of hematopoietic cells by identifying biological functions of two genes, Ikaros and Helios...
  2. Collagen X and heparan sulfate proteoglycan in the hematopoietic stem cell niche.
    ELIZABETH G SWEENEY; Fiscal Year: 2012
    ..phenotypes of all these mice may involve growth plate defects, an altered marrow environment and aberrant hematopoiesis. We proposed that collagen X and heparan sulfate proteoglycans, e.g...
  3. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
    ..Based on the zfrp8 mutant phenotype we predict that hematopoiesis is more involved and closer to the human model...
  4. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2011
    ..if abnormal expression of apoptosis-related target-genes contributes to myeloproliferation in ICSBP-deficient hematopoiesis. Aim 2: Determine if abnormal expression of target-genes which regulate DNA-repair and hematopoietic stem cell ..
  5. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
    ..goal is to understand the molecular and cellular mechanisms by which various factors interact to affect hematopoiesis. Our objective here is to characterize the functional implications of eicosanoid cross-regulation on HSC ..
  6. MECHANISMS OF EUKARYOTIC TRANSCRIPTIONAL REGULATION
    Michael R Green; Fiscal Year: 2013
    ..Trf3-depleted zebrafish embryos exhibit multiple developmental defects and, in particular, fail to undergo hematopoiesis. We have identified a single TRF3 target gene, mespa, which is required for early embryonic development and ..
  7. PEARLIE K BURNETTE; Fiscal Year: 2016
    ..alone is not expected to trigger migration and colonization in the bone marrow where these cells suppress hematopoiesis. The focus of Specific Aim 2 is to determine the mechanism of bone marrow homing by T cells in LGL leukemia ..
  8. In Vivo Function of TRAF6 As a Target of K63-Linked Polyubiquitination
    DEAN BALLARD; Fiscal Year: 2010
    ..Subsequent phenotypic studies will focus on defects associated with TRAF6 deficiency that impinge on hematopoiesis and osteoclastogenesis (Aim 1), innate immunity versus pathologic inflammation (Aim 2), and adaptive immunity (..
  9. Patrick Cahan; Fiscal Year: 2016
    ..who have consistently produced ground-breaking research in the areas of stem cell biology, development, hematopoiesis, chemical biology, transcription, cell cycle, and cancer genetics...
  10. J Evan Sadler; Fiscal Year: 2016
    ..and lysosomal storage diseases;phosphoinositide metabolism and cell signaling pathways;mechanisms of hematopoiesis;telomerase and ribosomal protein defects in bone marrow failure syndromes;molecular basis for protein ..
  11. Hematopoietic Stem Cells (HSCs) as Juvenile Protective Factors that Alter Aging
    David E Harrison; Fiscal Year: 2011
    ..Murine hematopoiesis is ideal for investigating stem cells, because lineages of marrow and blood precursors can be measured with ..
  12. B Cell Development in Aging
    John C Cambier; Fiscal Year: 2010
    ..Little is known regarding the patterns of histone modification and DNA methylation that impact early steps in hematopoiesis, and how these patterns might be altered during aging...
  13. Development of a Pediatric Mylelodysplastic Syndrome Patient Registry
    DAVID A contact WILLIAMS; Fiscal Year: 2010
    ..funds available through the challenge grants we are confident that with our unique expertise in the fields of hematopoiesis and hematopathology we are well equipped to establish a successful Pediatric MDS patient registry...
  14. Molecular Pathogenesis of MDS and CMML
    Jaroslaw P Maciejewski; Fiscal Year: 2013
    ..syndromes (MDS) is a heterogeneous group of bone marrow failure states characterized by dysplastic hematopoiesis, deficient blood cell production and a propensity to progression to acute myelogenous leukemia (AML);this ..
  15. GEORGE NORBERT COX; Fiscal Year: 2015
    ..Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first clinical signs of excessive radiation exposure, often resulting i death...
  16. TSAD AS AN EPOR/JAK2 ADAPTOR AND ERYTHROPOIETIC REGULATOR
    DONALD JOSEPH MCCRANN; Fiscal Year: 2010
    ..and workshops, our postdoctoral co-mentorship trainee program;co-development of a focused journal club in hematopoiesis;mentored construction of impacting scientific manuscripts;direct interactions with scientific collaborators;..
  17. Double Humanization of Liver and Blood in Mice
    ELIZABETH MARIE WILSON; Fiscal Year: 2012
    ..a protocol that permits the efficient generation of double- chimeric FRGN mice, with high levels of human hematopoiesis as well as high percentages of liver repopulation...
  18. GRANT ANTHONY CHALLEN; Fiscal Year: 2014
    ..Moreover, the diverse interests of the faculty of these Centers includes hematopoiesis, stem cell biology, hemopoietic stem cell transplantation, gene therapy, immunotherapy, and vector development ..
  19. GM-CSF analogs for treating acute radiation syndrome
    GEORGE NORBERT COX; Fiscal Year: 2010
    ..Bone marrow is one of the most sensitive tissues to radiation damage and impaired bone marrow hematopoiesis is one of the first clinical signs of excessive radiation exposure, often leading to death...
  20. Rafael Bejar; Fiscal Year: 2016
    ..Myelodysplastic syndromes are clonal disorders of hematopoiesis that cause inefficient blood cell production, low blood counts, and risk of progression to acute leukemia...
  21. Prevention of acute GvHD by inhibition of cdk2
    Vassiliki A Boussiotis; Fiscal Year: 2012
    ..cdk2 is essential for expansion of activated T cells, it is not critical for survival of resting lymphocytes, hematopoiesis or thymocyte development. These properties make cdk2 an attractive novel target for control of GvHD...
  22. Paul S Frenette; Fiscal Year: 2016
    ..Our preliminary studies suggest that a lesion to the SNS impairs the regeneration of the niche and recovery of hematopoiesis following a stressful challenge such as stem cell transplantation or 5-fluorouracyl (5FU) administration...
  23. Lung and bone marrow crosstalk during a respiratory infection
    CAROLINA B LOPEZ; Fiscal Year: 2010
    ..The BM, the primary site of hematopoiesis, is a likely supplier of pro-inflammatory cells to inflamed tissues...
  24. Qishen Pang; Fiscal Year: 2014
    ..by which Fanconi anemia (FA) proteins regulate cellular response to oxidative stress in the context of hematopoiesis. The process of FA disease progression is characterized by bone marrow failure (BMF), clonal proliferation of ..
  25. FASEB SRC on Hematopoietic Malignancies
    MICHELLE ALICE KELLIHER; Fiscal Year: 2011
    ..In addition, this year's meeting will include sessions on systems biology of hematopoiesis, stem cell biology, and the role of metabolic mutations in hematologic malignancies...
  26. Identification of Disease-Causing Mutations in SCID Using Exome-Wide Sequencing
    Joseph L Roberts; Fiscal Year: 2010
    ..These models are ideal for this purpose as essential elements of hematopoiesis are conserved and they enable rapid screening of effects of gene inactivation on development using either ..
  27. Role of Cited2 in Hematopoiesis
    Yu Chung Yang; Fiscal Year: 2011
    ..the maintenance and renewal of embryonic and adult stem cells, we studied the role of Cited2 in fetal liver hematopoiesis. Cited2-/- fetal liver displayed significant reduction in the numbers of hematopoietic cells in different ..
  28. There Will Be Blood: Stem Cell Niche Driven Derivation of HSC from ES Cells
    PAUL JOHN SIMMONS; Fiscal Year: 2010
    ..of emergence in the early embryo via a period of expansion in the fetal liver to the bone marrow, the site of hematopoiesis throughout adult life...
  29. The Role of Fibrocytes in Liver Fibrosis
    Tatiana Kisseleva; Fiscal Year: 2012
    ..that fibrocytes originate from c-kit+Sca-1+ hematopoietic stem cells, but developmentally precede CMP during hematopoiesis. In concordance, fibrocytes possess high plasticity, and in response to liver injury migrate to fibrotic liver,..
  30. Role of the zinc finger transcription factor ZBP89 in blood &vascular developmen
    M Amin Arnaout; Fiscal Year: 2013
    ..Forced expression of ZBP-89 increased expression of primitive and definitive hematopoiesis in zebrafish and in mouse embryonic stem cells (ESCs)/embryonic body (EB) cultures, but reduced axial and ..
  31. Pier Paolo Pandolfi; Fiscal Year: 2014
    ..structural similarities with BCL6 and PLZF and plays a critical and essential role in embryonic development, hematopoiesis and hematological malignancies...
  32. Jaroslaw P Maciejewski; Fiscal Year: 2014
    ..syndromes (MDS) is a heterogeneous group of bone marrow failure states characterized by dysplastic hematopoiesis, deficient blood cell production and a propensity to progression to acute myelogenous leukemia (AML);this ..
  33. Immune response to Pneumocystis and bone marrow failure
    Nicole Meissner; Fiscal Year: 2013
    ..In contrast T and B cell deficient RAG-/- mice with intact IFNAR demonstrated normal hematopoiesis during the course of infection and lymphocyte-competent but IFNAR- deficient IFNAR-/- mice showed depressed ..
  34. BENJAMIN LEVINE EBERT; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis, most commonly of the erythroid lineage, resulting in a phenotype termed refractory anemia...
  35. BENJAMIN BRAUN; Fiscal Year: 2016
    ..The proposed research will investigate the effects of hyperactive Ras/MEK signaling in hematopoiesis with the following aims: (1) in the mouse model, define mechanisms by which Ras/MEK signaling increases ..
  36. Shireen Saleque; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Hematopoiesis, the generation of blood cells, is a vital and essential developmental phenomenon providing oxygen supply, immune surveillance and hormone circulation to many organisms...
  37. Pankaj Gupta; Fiscal Year: 2014
    ..and mice deficient in HS biosynthesis, determine if and how osteoblast Gremlin1 influences (a) endogenous hematopoiesis, (b) the stem-cell supportive function of osteoblasts in vitro, and (c) HSC fate following transplantation...
  38. ALEXANDER C MINELLA; Fiscal Year: 2014
    ..We hypothesize that proper regulation of cyclin E is critical during normal hematopoiesis and that deregulated cell cycle controls contribute to the pathogenesis of blood diseases such as MDS and ..
  39. Oncogenic Kit receptor signaling in vivo
    Peter Besmer; Fiscal Year: 2012
    ..is twofold, 1) to continue our investigations of oncogenic Kit receptor signaling in vivo with emphasis on hematopoiesis and 2) to develop mouse models for imatinib resistant GIST...
  40. Amanda G Paulovich; Fiscal Year: 2016
    ..methods directly measures radiation damage to the bone marrow, nor do they indicate the existence of residual hematopoiesis, and most are not amenable to point-of-care in emergency conditions...
  41. Homing Receptor Determinants of HSC
    Irving L Weissman; Fiscal Year: 2013
    ..First, we identified the homing receptors and chemokine receptors used by HSC to home from blood to marrow hematopoiesis sites...
  42. Kira Gritsman; Fiscal Year: 2014
    ..PI3K may also be important during hematopoiesis, as it is activated by hematopoietic growth factor receptors, such as erythropoietin receptor, c-kit receptor, ..
  43. Parinda Mehta; Fiscal Year: 2015
    ..Our own preliminary data show that quercetin reverses the ill effects of ROS on hematopoiesis and insulin sensitivity in FA mice...
  44. Physiologic Regulation of Hematopoiesis by Notch
    Nadia Carlesso; Fiscal Year: 2011
    ..made in identifying key molecules that coordinate self-renewal, proliferation and differentiation during adult hematopoiesis, little is known about the physiologic and molecular regulation of these processes during bone marrow (BM) ..
  45. Defining Estrogenic Regulation of Hematopoietic Stem Cell Formation and Function
    Trista E North; Fiscal Year: 2013
    ..factor RUNX1, a frequent target of chromosomal mutation in leukemia, is expressed in all sites of de novo hematopoiesis and is absolutely required for HSC induction in mammals;runx1 expression is conserved in zebra fish...
  46. Lisa K Denzin; Fiscal Year: 2014
    ..Aberrant control of hematopoiesis is the underlying cause of many diseases including immune deficiency, anemia, autoimmunity, leukemia, and ..
  47. DHVANIT INDRAVADAN SHAH; Fiscal Year: 2014
    ..2) To identify the sav gene and its function in hematopoiesis. The positional cloning, loss-of-function, cRNA over-expression studies and mutational analyses will be ..
  48. CHARLES G SAGERSTROM; Fiscal Year: 2015
    ..g. dorsoventral patterning of the neural tube), and other aspects of embryogenesis (e.g. hematopoiesis)...
  49. Long-Acting G-CSF analogs for treating acute radiation syndrome
    GEORGE NORBERT COX; Fiscal Year: 2010
    ..Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first clinical signs of excessive radiation exposure, often resulting in death...
  50. MODELING AND RESCUE OF DBA IN THE MOUSE
    Philip J Mason; Fiscal Year: 2010
    ..Therefore we have generated a mouse model that closely mimics DBA hematopoiesis. We now propose to test our hypotheses and further characterize the block in red cell differentiation in these ..
  51. Slit2-mediated expansion of primitive hematopoietic stem cell populations for tra
    Gary Van Zant; Fiscal Year: 2010
    ..These results provide evidence that Slit2 is a novel regulator of murine hematopoiesis and a potential target for therapeutic intervention in the treatment of a variety of human diseases...
  52. Hal E Broxmeyer; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Hematopoiesis is balanced by self-renewal, proliferation, survival and differentiation of hematopoietic stem (HSC) and progenitor (HPC) cells...
  53. Osteoclasts from pluripotent stem cells as vectors to modify bone marrow environm
    Hector L Aguila; Fiscal Year: 2010
    ..We propose to selectively direct the development of human ES cells to hematopoiesis towards myeloid development, focusing on conditions to generate osteoclasts...
  54. Modulation of T cell Homeostasis in Myelodysplastic Syndrome (MDS)
    Javier Pinilla; Fiscal Year: 2012
    Myelodysplastic syndromes (MDS) are characterized by incompetent hematopoiesis that leads to single or multi-lineage peripheral cytopenias with the development of acute myeloid leukemia (AML) in approximately 30-40% of cases...
  55. Development of Inhibitors of the Leukemia Fusion Protein CBFbeta-SMMHC
    Roger A Rajewski; Fiscal Year: 2013
    ..of CBF function, binding RUNX1 and dysregulating the expression of multiple genes required for normal hematopoiesis. Current treatment utilizing cytotoxic chemotherapy results in 45-65% five year overall survival but only 20% ..
  56. Kentson Lam; Fiscal Year: 2014
    ..The long-term goal of this research project is to understand the function of AML1, also known as Runx1, in hematopoiesis. AML1 is a DNA binding transcription factor that is first expressed in hematopoietic stem/progenitor cells (..
  57. Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansion
    Harvey F Lodish; Fiscal Year: 2010
    ..Angptl2 and AngptIS are largely unstudied and have not previously been suggested to act on hematopoiesis or stem cells...
  58. Elizabeth J Shpall; Fiscal Year: 2014
    ..This can be achieved from small amounts of UCB to avoid compromising hematopoiesis in the recipient...
  59. Louis M Pelus; Fiscal Year: 2016
    ..important negative and positive physiological roles forprostaglandin E2 (PGE2) in normal and abnormal hematopoiesis. Recent evidence suggests that short-term in vitro xposure to PGE2 can enhance the engraftment of ..
  60. Functional study of novel transcriptional regulators of hematopoietic stem cells
    Shannon L McKinney-Freeman; Fiscal Year: 2012
    ..The ability of these cells to replenish hematopoiesis is exploited routinely to treat hematologic disease via bone marrow transplantation (BMT)...
  61. Reactive oxygen species and Genomic Instability in CML
    Martin Sattler; Fiscal Year: 2012
    ..In addition, relative levels of ROS are tightly regulated in normal hematopoiesis and are part of homeostatic mechanisms but they are chronically elevated in many cancers, including CML...
  62. Gary M Kupfer; Fiscal Year: 2014
    ..remains to be ascertained in normal FA biochemistry or about the manner in which FA proteins contribute to hematopoiesis and leukemia, as the FA proteins contain few known functional motifs...
  63. Christie M Orschell; Fiscal Year: 2016
    ..Bone marrow is one of the most sensitive tissues to radiation damage and impaired hematopoiesis is one of the first clinical signs of high dose radiation exposure, often resulting i death within weeks due ..
  64. The human placenta as a novel source of hematopoietic stem cells
    Alicia Barcena; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Human embryonic and fetal hematopoiesis occurs in stages as several anatomical sites become transiently active...
  65. Hematopoietic Stem Cells & Lympho-Hematopoiesis: Effect of Alcohol
    ROBERT WOLCOTT; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Chronic ingestion of alcohol can affect many aspects of hematopoiesis and the function of hematopoietic lineage cells...
  66. PROMYELOCYTIC ZINC FINGER GENE
    Jennifer Morris; Fiscal Year: 1999
    ..This suggests that PLZF may have a role in regulating normal hematopoiesis. Little is known about the molecular mechanisms by which PLZF normally regulates hematopoietic differentiation,..
  67. GENETIC ANALYSIS--DYSERYTHROPOIETIC ANEMIA IN ZEBRAFISH
    Barry Paw; Fiscal Year: 2000
    DESCRIPTION (adapted from the application) Hematopoiesis is a cascade of events leading from a pluripotent stem cell to terminally differentiated blood cells...
  68. Hyaluronan facilitates hematopoietic recovery following ionizing irradiation
    Sophia K Khaldoyanidi; Fiscal Year: 2010
    ..to eliminating proliferating hematopoietic progenitors, irradiation affects the structure and function of the hematopoiesis-supportive niche...
  69. MOLECULAR PATHWAYS IN MYELOPROLIFERATIVE DISEASE
    George Daley; Fiscal Year: 2002
    ..Normal hematopoiesis is regulated by cytokines, but the hallmark of myeloproliferative disease is autonomous hematopoiesis, a ..
  70. ETS-1 AND ELF-1 AND MEGAKARYOPOIESIS
    Kevin Barton; Fiscal Year: 2001
    Dr. Barton has the long term goal of pursuing independent investigation in the field of hematopoiesis. Receipt of a Mentored Clinical Scientist Development Award will facilitate the development of Dr...
  71. The Role of Geminin in Hematopoiesis
    Thomas McGarry; Fiscal Year: 2009
    ..replication and inhibits homeodomain (Hox) transcription factors that are known to be crucial regulators of hematopoiesis. Geminin knockdown activates the Fanconi Anemia pathway, and over- expression of the replication factor ..
  72. REGULATION OF NEUROKININ RECEPTORS IN BONE MARROW STROMA
    Pranela Rameshwar; Fiscal Year: 2000
    ..The mechanisms by which neuropeptides regulate hematopoiesis will add to the general understanding of the pathophysiology of diseases such as anemias and leukemias...
  73. PROTO-ONCOGENES IN MALIGNANT HEMATOPOIESIS
    Alan Gewirtz; Fiscal Year: 1993
    ..of this project are to: 1) determine the importance of specific protooncogenes in the regulation of malignant hematopoiesis, and 2) ascertain if blockade of oncogene encoded proteins will result in death of the malignant cell or ..