embryonic induction

Summary

Summary: The complex processes of initiating CELL DIFFERENTIATION in the EMBRYO. The precise regulation by cell interactions leads to diversity of cell types and specific pattern of organization (EMBRYOGENESIS).

Top Publications

  1. ncbi Initiation of neural induction by FGF signalling before gastrulation
    A Streit
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Nature 406:74-8. 2000
  2. pmc The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals
    S Piccolo
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles 90095 1662, USA
    Nature 397:707-10. 1999
  3. ncbi Neural induction: old problem, new findings, yet more questions
    Claudio D Stern
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 132:2007-21. 2005
  4. pmc Early development of the central and peripheral nervous systems is coordinated by Wnt and BMP signals
    Cedric Patthey
    Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
    PLoS ONE 3:e1625. 2008
  5. ncbi Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm
    A G Bang
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Development 124:2075-85. 1997
  6. ncbi Differential regulation of chordin expression domains in mutant zebrafish
    V E Miller-Bertoglio
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Dev Biol 192:537-50. 1997
  7. ncbi Reiterated Wnt signaling during zebrafish neural crest development
    Jessica L Lewis
    Molecular and Cellular Biology Program, University of Washington School of Medicine, Seattle, WA 98195, USA
    Development 131:1299-308. 2004
  8. ncbi The Wnt/beta-catenin pathway posteriorizes neural tissue in Xenopus by an indirect mechanism requiring FGF signalling
    P M Domingos
    Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Dev Biol 239:148-60. 2001
  9. ncbi Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
    A Glinka
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nature 391:357-62. 1998
  10. ncbi Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest
    Manuel J Aybar
    Millennium Nucleus in Developmental Biology, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    Development 130:483-94. 2003

Research Grants

  1. MECHANISMS OF MYOGENIC INDUCTION AND PATTERN IN SOMITES
    Frank Stockdale; Fiscal Year: 1999
  2. FIBROBLAST GROWTH FACTORS AND STRIATED MUSCLE
    JUDITH SWAIN; Fiscal Year: 1993
  3. FIBROBLAST GROWTH FACTORS AND STRIATED MUSCLE
    JUDITH SWAIN; Fiscal Year: 2001
  4. BXR SIGNALING IN VERTEBRATE DEVELOPMENT
    Bruce Blumberg; Fiscal Year: 2004
  5. EMBRYONIC INDUCTION IN DIFFERENTIATION THERAPY
    G Pierce; Fiscal Year: 1991
  6. TRAINING PROGRAM IN DEVELOPMENTAL BIOLOGY
    Raymond Keller; Fiscal Year: 2003
  7. PERIPHERAL SENSORY SYSTEM DEVELOPMENT & REGENERATION
    David Hill; Fiscal Year: 2003
  8. SIGNALING MECHANISMS FOR WNT PROTEINS
    Dianqing Wu; Fiscal Year: 2005
  9. GROWTH AND DIFFERENTIATION FACTORS IN DEVELOPMENT
    Charles Fox; Fiscal Year: 1990
  10. EARLY EVENTS IN NEURAL AND HOMEOGENETIC INDUCTION
    Claudio Stern; Fiscal Year: 2005

Detail Information

Publications230 found, 100 shown here

  1. ncbi Initiation of neural induction by FGF signalling before gastrulation
    A Streit
    Department of Genetics and Development, Columbia University, New York, New York 10032, USA
    Nature 406:74-8. 2000
    ..We show that the organizer and some of its precursor cells produce a fibroblast growth factor signal, which can initiate, and is required for, neural induction...
  2. pmc The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals
    S Piccolo
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles 90095 1662, USA
    Nature 397:707-10. 1999
    ..In order for the head territory to form, we propose that signals involved in trunk development, such as those involving BMP, Wnt and Nodal proteins, must be inhibited in rostral regions...
  3. ncbi Neural induction: old problem, new findings, yet more questions
    Claudio D Stern
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 132:2007-21. 2005
    ..This review summarizes neural induction events in different species and highlights some unanswered questions about this important developmental process...
  4. pmc Early development of the central and peripheral nervous systems is coordinated by Wnt and BMP signals
    Cedric Patthey
    Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
    PLoS ONE 3:e1625. 2008
    ....
  5. ncbi Expression of Pax-3 is initiated in the early neural plate by posteriorizing signals produced by the organizer and by posterior non-axial mesoderm
    A G Bang
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Development 124:2075-85. 1997
    ....
  6. ncbi Differential regulation of chordin expression domains in mutant zebrafish
    V E Miller-Bertoglio
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Dev Biol 192:537-50. 1997
    ..1989), while axial mesodermal expression was affected. This finding reveals an unexpected function for spadetail in midline mesoderm and in differential regulation of chordin expression during gastrulation...
  7. ncbi Reiterated Wnt signaling during zebrafish neural crest development
    Jessica L Lewis
    Molecular and Cellular Biology Program, University of Washington School of Medicine, Seattle, WA 98195, USA
    Development 131:1299-308. 2004
    ..Taken together, these results demonstrate that Wnt signals are critical for the initial induction of zebrafish neural crest and suggest that this signaling pathway plays reiterated roles in its development...
  8. ncbi The Wnt/beta-catenin pathway posteriorizes neural tissue in Xenopus by an indirect mechanism requiring FGF signalling
    P M Domingos
    Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Dev Biol 239:148-60. 2001
    ..We show that this posteriorizing activity occurs by an indirect and noncell-autonomous mechanism requiring FGF signalling...
  9. ncbi Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
    A Glinka
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nature 391:357-62. 1998
    ..Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 s a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors...
  10. ncbi Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest
    Manuel J Aybar
    Millennium Nucleus in Developmental Biology, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    Development 130:483-94. 2003
    ....
  11. pmc The lens: a classical model of embryonic induction providing new insights into cell determination in early development
    Lena Gunhaga
    Umeå Center for Molecular Medicine, Umea University, Building 6M, 4th Floor, 901 87 Umea, Sweden
    Philos Trans R Soc Lond B Biol Sci 366:1193-203. 2011
    The lens was the first tissue in which the concept of embryonic induction was demonstrated. For many years lens induction was thought to occur at the time the optic vesicle and lens placode came in contact...
  12. ncbi Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer
    C E Erter
    Department of Molecular Biology, Vanderbilt University, 1161 21st Avenue South, Nashville, Tennessee, 37232 2175, USA
    Dev Biol 204:361-72. 1998
    ..Our results suggest that znr2 encodes a robust mesendodermal inducer that signals nonautonomously during the earliest stages of embryonic patterning, and that part of this activity arises from within the YSL...
  13. ncbi Patterning activities of vertebrate hedgehog proteins in the developing eye and brain
    S C Ekker
    Johns Hopkins University School of Medicine, Department of Molecular Biology and Genetics, Baltimore, Maryland 21205, USA
    Curr Biol 5:944-55. 1995
    ..Within the neural tube, at the level of the spinal cord, products of the vertebrate gene sonic hedgehog (shh) are proposed to function as a ventral patterning influence, with the capability of inducing floor plate and motor neurons...
  14. ncbi Early development of the cranial sensory nervous system: from a common field to individual placodes
    Andrea Streit
    Department of Craniofacial Development, King s College London, Guy s Campus, London SE1 9RT, UK
    Dev Biol 276:1-15. 2004
    ....
  15. ncbi Genetic network during neural crest induction: from cell specification to cell survival
    Ben Steventon
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Semin Cell Dev Biol 16:647-54. 2005
    ..We will propose the division of this complex network of factors in two main steps: an initial cell specification step followed by a maintenance or cell survival step...
  16. ncbi Posteriorization by FGF, Wnt, and retinoic acid is required for neural crest induction
    Sandra Villanueva
    Millennium Nucleus in Developmental Biology, Facultad de Sciencias, Universidad de Chile, Santiago, Chile
    Dev Biol 241:289-301. 2002
    ..We discuss a unifying model where lateralizing and posteriorizing signals are presented as two stages of the same inductive process required for neural crest induction...
  17. pmc Proposal of a model of mammalian neural induction
    Ariel J Levine
    Laboratory of Molecular Vertebrate Embryology, The Rockefeller University, New York, NY 10021, USA
    Dev Biol 308:247-56. 2007
    ..This model is very similar to the default model of neural induction in the frog, thus bridging the evolutionary gap between amphibians and mammals...
  18. pmc Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos
    Wei Li
    Interdisciplinary Graduate Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Dev Biol 304:338-54. 2007
    ....
  19. ncbi Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula
    J A Belo
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles 90095 1662, USA
    Mech Dev 68:45-57. 1997
    ..A model of how head and trunk development might be regulated is discussed. Given its neuralizing activity, the secreted protein Cer-l is a candidate for mediating inductive activities of anterior visceral endoderm...
  20. ncbi The preplacodal region: an ectodermal domain with multipotential progenitors that contribute to sense organs and cranial sensory ganglia
    Andrea Streit
    Department of Craniofacial Development, King s College London, Guy s Campus, London, UK
    Int J Dev Biol 51:447-61. 2007
    ..Here I review the molecular mechanisms that sequentially subdivide the ectoderm to give rise to the placode territory...
  21. ncbi The status of Wnt signalling regulates neural and epidermal fates in the chick embryo
    S I Wilson
    Department of Microbiology, , , Sweden
    Nature 411:325-30. 2001
    ..Conversely, a lack of exposure of epiblast cells to Wnt signals permits FGFs to induce a neural fate...
  22. ncbi Induction and migration of the anterior visceral endoderm is regulated by the extra-embryonic ectoderm
    Tristan A Rodriguez
    Molecular Embryology Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK
    Development 132:2513-20. 2005
    ..Together, these data reveal a novel role for the ExE in the specification of the anteroposterior axis of the mouse embryo...
  23. pmc ADAM13 induces cranial neural crest by cleaving class B Ephrins and regulating Wnt signaling
    Shuo Wei
    Department of Cell Biology and the Morphogenesis and Regenerative Medicine Institute, University of Virginia, Charlottesville, 22908, USA
    Dev Cell 19:345-52. 2010
    ..We propose that by cleaving class B Efns, ADAM13 promotes canonical Wnt signaling and early CNC induction...
  24. ncbi Perception of differentiation cues by GATA factors in primitive endoderm lineage determination of mouse embryonic stem cells
    Callinice D Capo-chichi
    Ovarian Cancer and Tumor Cell Biology Programs, Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111 2497, USA
    Dev Biol 286:574-86. 2005
    ..This study indicates that the lineage differentiation of ES cells can be manipulated by the expression of GATA factors...
  25. ncbi Patterning of the mesoderm in Xenopus: dose-dependent and synergistic effects of Brachyury and Pintallavis
    M A O'Reilly
    Laboratory of Developmental Biology, National Institute for Medical Research, London, UK
    Development 121:1351-9. 1995
    ..These results suggest that Pintallavis cooperates with Brachyury to pattern the mesoderm in Xenopus...
  26. ncbi (beta)-catenin mediates the specification of endoderm cells in ascidian embryos
    K Imai
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Development 127:3009-20. 2000
    ..These results suggest that the accumulation of (beta)-catenin in the nuclei of endoderm progenitor cells is the first step in the process of ascidian endoderm specification...
  27. ncbi Differential distribution of competence for panplacodal and neural crest induction to non-neural and neural ectoderm
    Mareike Pieper
    Brain Research Institute, University of Bremen, FB2, PO Box 330440, 28334 Bremen, Germany
    Development 139:1175-87. 2012
    ....
  28. ncbi The organizer of the mouse gastrula is composed of a dynamic population of progenitor cells for the axial mesoderm
    S J Kinder
    Embryology Unit, Children s Medical Research Institute, Locked Bag 23, Wentworthville, NSW 2145, Australia
    Development 128:3623-34. 2001
    ..The gastrula organizer is therefore composed of a constantly changing population of cells that are allocated to different parts of the axial mesoderm...
  29. pmc Snail2 controls mesodermal BMP/Wnt induction of neural crest
    Jianli Shi
    Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309 0347, USA
    Development 138:3135-45. 2011
    ..Taken together, these results identify Snail2 as a key regulator of the signals involved in mesodermal induction of neural crest...
  30. ncbi The role of micromere signaling in Notch activation and mesoderm specification during sea urchin embryogenesis
    H C Sweet
    Department of Biological Sciences and Science and Technology Center for Light Microscope Imaging and Biotechnology, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Development 126:5255-65. 1999
    ..We propose that the micromeres induce adjacent cells to form SMCs, possibly by presenting a ligand for the Notch receptor...
  31. ncbi The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
    C Yost
    Department of Biochemistry, University of Washington School of Medicine, Seattle, 98195 7370, USA
    Genes Dev 10:1443-54. 1996
    ..These studies provide a basis for understanding the interaction between Xgsk-3 and beta-catenin in the establishment of the dorsal-ventral axis in early Xenopus embryos...
  32. ncbi Signals derived from the underlying mesoderm are dispensable for zebrafish neural crest induction
    Jared W Ragland
    Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195 7420, USA
    Dev Biol 276:16-30. 2004
    ....
  33. ncbi Interplay between Notch signaling and the homeoprotein Xiro1 is required for neural crest induction in Xenopus embryos
    Alvaro Glavic
    Millennium Nucleus in Developmental Biology, Faculty of Science, University of Chile, Casilla 653, Santiago, Chile
    Development 131:347-59. 2004
    ..These data also highlight the different roles played by BMP in neural crest specification in chick and Xenopus or zebrafish embryos...
  34. ncbi A micromere induction signal is activated by beta-catenin and acts through notch to initiate specification of secondary mesenchyme cells in the sea urchin embryo
    D R McClay
    Department of Biology, DCMB Group, Box 91000, Duke University, Durham, NC 27708, USA
    Development 127:5113-22. 2000
    ..As Notch is maternally expressed in macromeres, additional components must be downstream of nuclear beta-catenin in macromeres for these cells to receive and transduce the micromere induction signal...
  35. ncbi Chordin regulates primitive streak development and the stability of induced neural cells, but is not sufficient for neural induction in the chick embryo
    A Streit
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 125:507-19. 1998
    ..These results suggest that the regulation of BMP signalling by chordin plays a role in primitive streak formation and that chordin is not sufficient to induce neural tissue...
  36. ncbi Murine cerberus homologue mCer-1: a candidate anterior patterning molecule
    C Biben
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Dev Biol 194:135-51. 1998
    ..The data suggest that mCer-1 shares structural, functional, and expression characteristics with Xcer and may participate in patterning the anterior of the embryo and nascent somite region, in part, through a BMP-inhibitory mechanism...
  37. ncbi A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrula
    M Fürthauer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, Illkirch, France
    Development 124:4253-64. 1997
    ..We conclude that FGF-8 is involved in defining dorsoventral identity and is an important organizing factor responsible for specification of mesodermal and ectodermal dorsolateral territories of the zebrafish gastrula...
  38. ncbi The migration of cerebellar rhombic lip derivatives
    Jonathan D Gilthorpe
    MRC Centre for Developmental Neurobiology, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, UK
    Development 129:4719-28. 2002
    ..The use of axons in navigating cell movement suggests that tangential migration is an elaboration of the normal process of axon extension...
  39. ncbi Expression of Pax-3 in the lateral neural plate is dependent on a Wnt-mediated signal from posterior nonaxial mesoderm
    A G Bang
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California, 92037, USA
    Dev Biol 212:366-80. 1999
    ....
  40. pmc BMP4 is essential for lens induction in the mouse embryo
    Y Furuta
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175 USA
    Genes Dev 12:3764-75. 1998
    ..Based on these results we propose that BMP4 is required for the optic vesicle to manifest its lens-inducing activity, by regulating downstream genes and/or serving as one component of multiple inductive signals...
  41. ncbi Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8
    S Wang
    Laboratory of Developmental Biology, Food and Drug Administration, Bethesda, Maryland 20892, USA
    Cell 88:757-66. 1997
    ..These observations implicate Frzb in axial patterning and support the concept that Frzb binds and inactivates Xwnt-8 during gastrulation, preventing inappropriate ventral signaling in developing dorsal tissues...
  42. pmc Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneurones
    Will H Norton
    Department of Anatomy and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK
    Development 132:645-58. 2005
    ....
  43. ncbi Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGF-beta family signals and discrimination of mesoderm and endoderm by FGF
    A Rodaway
    Developmental Biology Research Centre, Randall Institute, King s College London, London, WC2B 5RL, UK
    Development 126:3067-78. 1999
    ....
  44. ncbi Gata factor Pannier is required to establish competence for heart progenitor formation
    Susan L Klinedinst
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Development 130:3027-38. 2003
    ..In support, we find that manipulation of pannier activity in either germ layer affects cardiac specification, suggesting that its function is required in both the mesoderm and the ectoderm...
  45. ncbi Injected Wnt RNA induces a complete body axis in Xenopus embryos
    S Sokol
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138
    Cell 67:741-52. 1991
    ..The relationship between the properties of the endogenous dorsal inducer and the effects of Wnts and activins is discussed...
  46. pmc A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner
    Y Yamanaka
    Division of Molecular Oncology, Biomedical Research Center, Osaka University Medical School Osaka 565 0871, Japan
    Genes Dev 12:2345-53. 1998
    ..Furthermore, dharma expressed in the YSL induced the organizer in a non-cell-autonomous manner. These results provided the first identification of a zygotic gene to be implicated in the formation of an organizer-inducing center...
  47. ncbi Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
    K F Liem
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 82:969-79. 1995
    ....
  48. ncbi Neural crest induction in Xenopus: evidence for a two-signal model
    C LaBonne
    Division of Biology, Beckman Institute 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Development 125:2403-14. 1998
    ..Slug-expressing ectoderm will generate neural crest in the presence of Wnt or FGF-like signals, however, bypassing the need for BMP inhibition in this process. A two-step model for neural crest induction is proposed...
  49. ncbi A role for frizzled 3 in neural crest development
    M A Deardorff
    Cell and Molecular Biology Graduate Group (School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Development 128:3655-63. 2001
    ..These results show that Xfz3 is required for Xwnt1 signaling in the formation of the neural crest in the developing vertebrate embryo...
  50. ncbi Initial anteroposterior pattern of the zebrafish central nervous system is determined by differential competence of the epiblast
    S Koshida
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, Japan
    Development 125:1957-66. 1998
    ..However, the requirement for FGF signalling is indirect in that cells with compromised ability to respond to FGF can still respond to anteroposterior positional information...
  51. ncbi Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesoderm
    W C Smith
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Nature 361:547-9. 1993
    ..Dorsal pattern can be partially rescued in ventralized embryos by injection of a plasmid that expresses noggin during gastrulation. The results suggest that the noggin product may be the dorsalizing signal from the organizer...
  52. ncbi Identification of neural crest competence territory: role of Wnt signaling
    Francisco Bastidas
    Millennium Nucleus in Developmental Biology, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    Dev Dyn 229:109-17. 2004
    ..Developmental Dynamics 229:109-117, 2004...
  53. pmc Cell communication with the neural plate is required for induction of neural markers by BMP inhibition: evidence for homeogenetic induction and implications for Xenopus animal cap and chick explant assays
    Claudia Linker
    Department of Cell and Developmental Biology, University College London, Gower Street Anatomy Building, London WC1E 6BT, UK
    Dev Biol 327:478-86. 2009
    ..We propose that the animal cap assay in Xenopus and explant assays in the chick are unsuitable for studying instructive signals in neural induction...
  54. ncbi Conditional BMP inhibition in Xenopus reveals stage-specific roles for BMPs in neural and neural crest induction
    Stefan Wawersik
    Department of Cell Biology, Harvard Medical School, Boston, MA 02215, USA
    Dev Biol 277:425-42. 2005
    ..Thus, BMP inhibition during gastrulation is insufficient for neural induction in intact embryos, arguing against a BMP gradient as the sole determinant of ectodermal cell fate in the frog...
  55. ncbi Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis
    A Ruiz i Altaba
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, N Y 10032
    Development 116:81-93. 1992
    ..Our results suggest that Pintallavis functions in the induction and patterning of the neural axis...
  56. ncbi Wnt genes
    R Nusse
    Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305
    Cell 69:1073-87. 1992
  57. pmc Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction
    Edgar M Pera
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California Los Angeles, Los Angeles, CA 90095 1662, USA
    Genes Dev 17:3023-8. 2003
    ..This hard-wired molecular mechanism at the level of the Smad1 transcription factor may help explain the opposing activities of IGF, FGF, and BMP signals not only in neural induction, but also in other aspects of vertebrate development...
  58. ncbi Ectodermal Wnt function as a neural crest inducer
    MARTIN I GARCIA-CASTRO
    Division of Biology 139 74, California Institute of Technology, Wilson and California, Pasadena, CA 91125, USA
    Science 297:848-51. 2002
    ..Our data suggest that Wnt molecules are necessary and sufficient to induce neural crest cells in avian embryos...
  59. pmc FGF8 initiates inner ear induction in chick and mouse
    Raj K Ladher
    Sensory Development, RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    Genes Dev 19:603-13. 2005
    ..Thus, Fgf8 plays a critical upstream role in an FGF signaling cascade required for otic induction in chick and mouse...
  60. ncbi A new role for the Endothelin-1/Endothelin-A receptor signaling during early neural crest specification
    Marcela Bonano
    Departamento de Biologia del Desarrollo, INSIBIO CONICET Universidad Nacional de Tucumán, Chacabuco 461, T4000ILI San Miguel de TucumAn, Tucuman, Argentina
    Dev Biol 323:114-29. 2008
    ..Together, our results provide insight on a new role of Edn1/Ednra cell signaling pathway during early neural crest development...
  61. ncbi A gene regulatory network orchestrates neural crest formation
    Tatjana Sauka-Spengler
    Division of Biology 13974, California Institute of Technology, Pasadena, California 91125, USA
    Nat Rev Mol Cell Biol 9:557-68. 2008
    ..Here, we review our current understanding of these processes and discuss the molecular players that are involved in the neural crest gene regulatory network...
  62. ncbi Chordin is required for the Spemann organizer transplantation phenomenon in Xenopus embryos
    Michael Oelgeschlager
    Howard Hughes Medical Institute and Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Dev Cell 4:219-30. 2003
    ..Unexpectedly, transplantations into the dorsal side revealed a cell-autonomous requirement of Chordin for neural plate differentiation...
  63. pmc Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer
    L Leyns
    Department of Biological Chemistry, University of California, Los Angeles 90095 1662, USA
    Cell 88:747-56. 1997
    ..Cultured cells transfected with a membrane-tethered form of Wnt-1 bind epitope-tagged Frzb-1 in the 10(-10) M range. The results strengthen the view that the Spemann organizer is a source of secreted inhibitory factors...
  64. ncbi The Xenopus POU class V transcription factor XOct-25 inhibits ectodermal competence to respond to bone morphogenetic protein-mediated embryonic induction
    Kimiko Takebayashi-Suzuki
    Institute for Amphibian Biology, Hiroshima University Graduate School of Science, Kagamiyama 1 3 1, Higashi Hiroshima 739 8526, Japan
    Mech Dev 124:840-55. 2007
    ..results document an essential role for XOct-25 in commitment to neural or epidermal cell fates in the ectoderm and highlight the importance of a regulatory mechanism that limits competence to respond to BMP-mediated embryonic induction.
  65. ncbi Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis
    F Reifers
    Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    Development 125:2381-95. 1998
    ..Fgf8 is therefore required in development of several important signaling centers in the zebrafish embryo, but may be redundant or dispensable for others...
  66. ncbi Msx1 and Pax3 cooperate to mediate FGF8 and WNT signals during Xenopus neural crest induction
    Anne Hélène Monsoro-Burq
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA
    Dev Cell 8:167-78. 2005
    ..Thus, WNT and FGF8 signals act in parallel at the neural border and converge on Pax3 activity during neural crest induction...
  67. pmc A new method to transfect the hypoblast of the chick embryo reveals conservation of the regulation of an Otx2 enhancer between mouse and chick extraembryonic endoderm
    Amanda Albazerchi
    Department of Anatomy and Developmental Biology, University College London, London, UK
    BMC Dev Biol 7:25. 2007
    ....
  68. ncbi Vertebrate cranial placodes I. Embryonic induction
    C V Baker
    Division of Biology 139 74, California Institute of Technology, Pasadena, California, 91125, USA
    Dev Biol 232:1-61. 2001
    ....
  69. ncbi Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo
    C E Erter
    Department of Cell Biology, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN 37232 2175, USA
    Development 128:3571-83. 2001
    ....
  70. ncbi Induction of the prospective neural crest of Xenopus
    R Mayor
    Laboratory of Developmental Biology, National Institute for Medical Research, Mill Hill, London, UK
    Development 121:767-77. 1995
    ..At certain doses, the cranial crest domains are not separated into lateral masses and there is a reduction in the size of the neural plate...
  71. ncbi A molecular pathway determining left-right asymmetry in chick embryogenesis
    M Levin
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 82:803-14. 1995
    ..Together, these observations identify a cascade of molecular asymmetry in that determines morphological LR asymmetry in the chick embryo...
  72. ncbi Requirement for Lim1 in head-organizer function
    W Shawlot
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 374:425-30. 1995
    ..A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer...
  73. ncbi Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation
    C M Jones
    Department of Cell Biology, Vanderbilt University Medical School, Nashville, TN 37232 2175, USA
    Development 121:3651-62. 1995
    ....
  74. ncbi The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation
    L Zeng
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Cell 90:181-92. 1997
    ..Thus, Axin is a novel inhibitor of Wnt signaling and regulates an early step in embryonic axis formation in mammals and amphibians...
  75. ncbi A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord
    K F Liem
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Cell 91:127-38. 1997
    ..These inductive interactions involve both qualitative and quantitative differences in signaling by TGFbeta-related factors and temporal changes in the response of neural progenitor cells...
  76. ncbi Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction
    Y Kamachi
    Institute for Molecular and Cellular Biology, Osaka University, Suita, Osaka 565 0871, Japan
    Development 125:2521-32. 1998
    ..Continued activity, especially of SOX1, is then essential for further development of the lens...
  77. ncbi Neural induction, the default model and embryonic stem cells
    Ignacio Munoz-Sanjuan
    Laboratory of Molecular Vertebrate Embryology, The Rockefeller University, New York, New York 10021, USA
    Nat Rev Neurosci 3:271-80. 2002
  78. ncbi Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry
    M R Rebagliati
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Biol 199:261-72. 1998
    ..We suggest that Ndr1 has a role in mesoderm induction, while Ndr2 is involved in subsequent specification and patterning of the nervous system and establishment of laterality...
  79. ncbi Churchill, a zinc finger transcriptional activator, regulates the transition between gastrulation and neurulation
    Guojun Sheng
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Cell 115:603-13. 2003
    ..These results reveal that neural induction requires cessation of mesoderm formation at the midline in addition to the decision between epidermis and neural plate...
  80. ncbi Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos
    W C Smith
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cell 70:829-40. 1992
    ..The activity of exogenous noggin RNA in embryonic axis induction and the localized expression of endogenous noggin transcripts suggest that noggin plays a role in normal dorsal development...
  81. ncbi Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes
    V H Nguyen
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Dev Biol 199:93-110. 1998
    ..Based on the alterations in tissue-specific gene expression, we propose a model whereby swirl/bmp2b acts as a morphogen to specify different cell types along the dorsoventral axis...
  82. ncbi Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
    J Ericson
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 90:169-80. 1997
    ..2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain...
  83. ncbi Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning
    V Gawantka
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Mech Dev 77:95-141. 1998
    ..In conclusion, this study describes a semi-functional approach to investigate genes expressed during early development and provides global insight into embryonic patterning...
  84. ncbi A role for HGF/SF in neural induction and its expression in Hensen's node during gastrulation
    A Streit
    University of Manchester, UK
    Development 121:813-24. 1995
    ..We therefore propose that HGF/SF plays a role during the early steps of neural induction, perhaps by inducing or maintaining the competence of the epiblast to respond to neural inducing signals...
  85. ncbi Neural induction by the secreted polypeptide noggin
    T M Lamb
    Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Science 262:713-8. 1993
    ..Noggin induces cement glands and anterior brain markers, but not hindbrain or spinal cord markers. Thus, noggin has the expression pattern and activity expected of an endogenous neural inducer...
  86. pmc Xenopus Zic3, a primary regulator both in neural and neural crest development
    K Nakata
    Molecular Neurobiology Laboratory, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Tsukuba, Ibaraki 305, Japan
    Proc Natl Acad Sci U S A 94:11980-5. 1997
    ..These findings suggest that Zic3 can determine the ectodermal cell fate and promote the earliest step of neural and neural crest development...
  87. ncbi A role for the hypoblast (AVE) in the initiation of neural induction, independent of its ability to position the primitive streak
    Amanda Albazerchi
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Dev Biol 301:489-503. 2007
    ..Interestingly, FGF and retinoids, generally considered as caudalizing factors, are shown here to play a role in the induction of a transient "pre-neural/pre-forebrain" state...
  88. pmc Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning
    S L Nutt
    Wellcome CRC Institute, Cambridge CB2 1QR, UK and Department of Zoology, University of Cambridge CB2 3EJ, UK
    Genes Dev 15:1152-66. 2001
    ....
  89. ncbi Micromere descendants at the blastula stage are involved in normal archenteron formation in sea urchin embryos
    Y Ishizuka
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    Dev Genes Evol 211:83-8. 2001
    ..These results indicate that at the hatching blastula stage, micromere descendants emanate a signal(s) required for normal gastrulation of the presumptive endo-mesodermal region...
  90. ncbi Neural induction requires BMP inhibition only as a late step, and involves signals other than FGF and Wnt antagonists
    Claudia Linker
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 131:5671-81. 2004
    ..We propose that neural induction involves additional signalling events that remain to be identified...
  91. pmc The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse
    Z Gu
    Cardiovascular Research Center, Massachusetts General Hospital East, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 12:844-57. 1998
    ..These results provide genetic evidence that ActRIB functions in both epiblast and extraembryonic cells to mediate signals that are required for egg cylinder organization and gastrulation...
  92. ncbi Induction of the neural crest and the opportunities of life on the edge
    Xiao Huang
    Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 275:1-11. 2004
    ..We also summarize some of these findings and discuss how the differential activation of these genes may contribute to the establishment of neural crest diversity...
  93. ncbi Zebrafish organizer development and germ-layer formation require nodal-related signals
    B Feldman
    Developmental Genetics Program, Skirball Institute of Biomolecular Medicine and Department of Cell Biology, New York University Medical Center, New York 10016, USA
    Nature 395:181-5. 1998
    ..Misexpression of sqt RNA within the embryo or specifically in the YSL induces expanded or ectopic dorsal mesoderm. These results establish an essential role for nodal-related signals in organizer development and mesendoderm formation...
  94. ncbi A gene network establishing polarity in the early mouse embryo
    Siew Lan Ang
    Division of Developmental Neurobiology, NIMR, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Semin Cell Dev Biol 15:555-61. 2004
    ..This likely results in an activity gradient which is instrumental to pattern the embryo proper...
  95. ncbi Induction of cardiomyocytes by GATA4 in Xenopus ectodermal explants
    Branko V Latinkic
    Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    Development 130:3865-76. 2003
    ..Better knowledge of the pathways governing this process may help develop procedures for efficient generation of cardiomyocytes from pluripotent stem cells...
  96. ncbi Regionally specific induction by the Spemann-Mangold organizer
    Christof Niehrs
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Rev Genet 5:425-34. 2004
  97. ncbi Neural induction: toward a unifying mechanism
    S I Wilson
    Department of Molecular Biology, Umea University, S 901 87 Umea, Sweden
    Nat Neurosci 4:1161-8. 2001
    ..Here we highlight the similarities and the differences, and we propose a possible unifying mechanism...
  98. ncbi Promoting notochord fate and repressing muscle development in zebrafish axial mesoderm
    S L Amacher
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403 1254, USA
    Development 125:1397-406. 1998
    ....
  99. pmc Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2
    M Weinstein
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, 10 9N105, 10 Center Drive, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:9378-83. 1998
    ..Molecular analysis showed that smad2 mutant embryos did not undergo gastrulation or make mesoderm. The results demonstrate that smad2 is required for egg cylinder elongation, gastrulation, and mesoderm induction...
  100. ncbi Anterior identity is established in chick epiblast by hypoblast and anterior definitive endoderm
    Susan C Chapman
    MRC Centre for Developmental Neurobiology, Kings College London, New Hunts House, Guy s Hospital, London SE1 1UL, UK
    Development 130:5091-101. 2003
    ..Based on this new evidence we propose a revised model for establishing anteroposterior polarity, neural specification and head patterning in the early chick that is consonant with that occurring in other vertebrates...
  101. ncbi Specification of dorsal telencephalic character by sequential Wnt and FGF signaling
    Lena Gunhaga
    Umeå Center for Molecular Medicine, Building 6M, 4th Floor, Umea University, S 901 87 Umea, Sweden
    Nat Neurosci 6:701-7. 2003
    ..Here we show in chick embryos that sequential Wnt and fibroblast growth factor (FGF) signaling specifies cells of dorsal telencephalic character...

Research Grants62

  1. MECHANISMS OF MYOGENIC INDUCTION AND PATTERN IN SOMITES
    Frank Stockdale; Fiscal Year: 1999
    ..the mechanism by which cell interactions specify embryonic cells to particular fates and patterns during embryonic induction. We have developed a model system to define the roles that axial embryonic structures, the neural tube and ..
  2. FIBROBLAST GROWTH FACTORS AND STRIATED MUSCLE
    JUDITH SWAIN; Fiscal Year: 1993
    ..The functions of FGF in vivo are postulated to include embryonic induction, stimulation of angiogenesis, promotion of regenerative processes such as wound healing, and stimulation of ..
  3. FIBROBLAST GROWTH FACTORS AND STRIATED MUSCLE
    JUDITH SWAIN; Fiscal Year: 2001
    ..The functions of FGF in vivo are postulated to include embryonic induction, stimulation of angiogenesis, promotion of regenerative processes such as wound healing, and stimulation of ..
  4. BXR SIGNALING IN VERTEBRATE DEVELOPMENT
    Bruce Blumberg; Fiscal Year: 2004
    ..Positional information is involved in important developmental processes including embryonic induction, differential competence of the responding tissue, and cytoplasmic specification...
  5. EMBRYONIC INDUCTION IN DIFFERENTIATION THERAPY
    G Pierce; Fiscal Year: 1991
    ....
  6. TRAINING PROGRAM IN DEVELOPMENTAL BIOLOGY
    Raymond Keller; Fiscal Year: 2003
    ..These include regulation of gene expression, cell signaling, cell and tissue interactions, embryonic induction and patterning, cell determination and differentiation, and many aspects of morphogenesis, such as cell ..
  7. PERIPHERAL SENSORY SYSTEM DEVELOPMENT & REGENERATION
    David Hill; Fiscal Year: 2003
    ..In Project 1 the early embryonic induction of olfactory- and auditory-related structures will be studied...
  8. SIGNALING MECHANISMS FOR WNT PROTEINS
    Dianqing Wu; Fiscal Year: 2005
    ..is one of the major families of developmentally important signaling molecules and plays important roles in embryonic induction, generation of cell polarity, and specification of cell fate...
  9. GROWTH AND DIFFERENTIATION FACTORS IN DEVELOPMENT
    Charles Fox; Fiscal Year: 1990
    ..of grow-factor like molecules and receptors regulating cell proliferation, differentiation and embryonic induction. Considerable progress in this field has led to identification of new vertebrate factors, many of them ..
  10. EARLY EVENTS IN NEURAL AND HOMEOGENETIC INDUCTION
    Claudio Stern; Fiscal Year: 2005
    ..D. To explore the possible roles of 6 newly-identified candidate secreted factors in the early steps of neural induction and homeogenetic induction. ..
  11. Wnt Pathway Regulation in Embryos and Cells
    David Kimelman; Fiscal Year: 2009
    ..Since the Wnt pathway plays key roles in vertebrate development and oncogenesis, these studies will be important in advancing knowledge of the molecular basis of birth defects and cancer. ..
  12. Replacing an Animal Resource Facility Cage Washer.
    Kristen Drescher; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  13. Combinatorial signaling in zebrafish development
    David Kimelman; Fiscal Year: 2005
    ..abstract_text> ..
  14. MOLECULAR AND CELLULAR BASIS OF LENS DEVELOPMENT
    Jonathan J Henry; Fiscal Year: 2010
    ....
  15. REGULATION OF CARDIAC CONDUCTION SYSTEM DEVELOPMENT
    Takashi Mikawa; Fiscal Year: 2007
    ..The studies proposed here will identify the regulators of three critical mechanisms in establishing the Purkinje fiber network and build a foundation for rational therapeutics for conduction disorder in adults. [unreadable] [unreadable]..
  16. GENETIC BASIS OF VERTEBRATE SEGMENTATION
    Christopher Kintner; Fiscal Year: 2007
    ..Results from these experiments will generate basic knowledge about a developmental mechanism that is key to the formation of the vertebrate body plan, ir_cluding that of humans. ..
  17. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2007
    ..Thus it is critical to identify and study all the genetic players in this process. ..
  18. INDUCTION OF THE NEURAL CREST
    Marianne Bronner Fraser; Fiscal Year: 2008
    ..3. Examine the possible role of Notch signaling in cell fate decisions within the neural folds as cells choose between neural crest, neural tube or epidermal fates. ..
  19. Specification of embryonic C. elegans mesoderm by a T-box factor
    Morris Maduro; Fiscal Year: 2008
    ..elegans may shed light on how development goes awry, a process which can lead to birth defects or cancer. [unreadable] [unreadable] [unreadable]..
  20. Molecular analysis of neural crest migration
    Marianne Bronner Fraser; Fiscal Year: 2007
    ..2. The function of the a5 subunit of laminin in early neural crest development. 3. The function of a novel chemokine in neural crest migration. 4. The function of this novel chemokine in limb development. ..
  21. GERM LAYER SPECIFICATION
    DAVID MC CLAY; Fiscal Year: 2007
    ..This network eventually will enable us to explore how positional cues are produced and displayed for later morphogenetic patterning. ..
  22. "Vasculata 2007" Conference grant application
    Victoria Bautch; Fiscal Year: 2007
    ..We are particularly interested in reaching out to minority participants and providing them with full scholarships. (End of Abstract) [unreadable] [unreadable] [unreadable]..
  23. A novel Dlg isoform and identification of its interacting proteins
    Kyung Ok Cho; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  24. REGIONAL DIFFERENTIATION DURING FOREBRAIN DEVELOPMENT
    Anthony S LaMantia; Fiscal Year: 2010
    ....
  25. Developing vision: Wnts in programmed vessel regression
    Richard Lang; Fiscal Year: 2008
    ....
  26. Role of Vascular Cells in kidney pattern formation
    Jordan A Kreidberg; Fiscal Year: 2010
    ..The aims of this grant are designed to more fully determine the molecular nature of the angioblast signal, and how it may be involved in stimulating branching, and patterning the embryonic kidney. ..
  27. Integrating Cell Division and Morphogenesis in Developing Vessels
    Victoria L Bautch; Fiscal Year: 2010
    ..The results will help us understand how vessels are shaped, which in turn will aid in designing ways to make artificial vessels for therapeutic use. ..
  28. CRIM1-b-Catenin-Cadherin Interactions in Eye Development and Disease
    RICHARD A contact LANG; Fiscal Year: 2010
    ..The down-regulation of cadherin expression and activity is also know to be a critical step in epithelial tumor progression as it allows tumor cells to leave the epithelium, become invasive and ultimately form metastases. ..
  29. OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATION
    Blanche Capel; Fiscal Year: 2010
    ....
  30. Genetic analysis of ovary development and oogenesis
    Mary Mullins; Fiscal Year: 2009
    ..Identification of the mutant zebrafish genes will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
  31. Gap junctional communication during zebrafish fin growth
    MARY IOVINE; Fiscal Year: 2009
    ..Furthermore, these insights will directly facilitate future understanding of the biology of human bone malformations. ..
  32. Network Interaction between EGFR and TGFbeta Pathways
    WILLIS LI; Fiscal Year: 2009
    ..abstract_text> ..
  33. Integrins in epithelial morphogenesis
    Jordan Kreidberg; Fiscal Year: 2009
    ..Specific Aim 2: To examine the role of integrin-dependent Writ signaling in epithelial morphogenesis. Specific Aim 3: To determine the requirement for a3b1 integrin:tetraspanin interaction in morphogenesis of the collecting system. ..
  34. CELL-MATRIX INTERACTIONS IN AMPHIBIAN DEVELOPMENT
    Douglas DeSimone; Fiscal Year: 2009
    ..abstract_text> ..
  35. Development of Cranial Motor Neurons
    Anand Chandrasekhar; Fiscal Year: 2007
    ..Together, these experiments will generate novel insight into neuronal migration mechanisms in the vertebrate hindbrain. ..
  36. Organ-specific Mechanisms of Vascular Development
    Blanche Capel; Fiscal Year: 2007
    ..In addition, the molecular signals that control or repress the growth of vasculature into a tissue are of critical concern for the design of therapies in the fields of wound healing and tumor biology. [unreadable] [unreadable]..
  37. Genetic control of podocyte function
    Jordan Kreidberg; Fiscal Year: 2007
    ..abstract_text> ..
  38. Stromal Epithelial Interactions in Breast Cancer
    Gerald Cunha; Fiscal Year: 2004
    ..To accomplish these goals we will use tissue recombinant technology, cell and organ culture, immunocytochemistry, and various molecular methodologies. ..
  39. A ROLE FOR NOGGIN AND BMP2/4 IN HAIR GROWTH CONTROL
    Vladimir Botchkarev; Fiscal Year: 2003
    ..abstract_text> ..
  40. Cyclic Nucleotides and the Response to Sonic Hedgehog
    Henk Roelink; Fiscal Year: 2003
    ....
  41. INDUCTION OF THE NEURAL CREST
    Marianne Bronner Fraser; Fiscal Year: 2001
    ..that neural crest cells are generated when epidermis and neural plate are juxtaposed-a classic type of embryonic induction. The proposed experiments aim to characterize this inductive interaction that leads to neural crest ..
  42. VASCULOGENESIS IN THE MURINE ALLANTOIS
    KAREN DOWNS; Fiscal Year: 2002
    ..Further, results of our experiments will shed light on the mechanism of formation of the endothelial cell lineage. ..
  43. Novel Method for Targeted Gene Disruption in the Ear
    Andrew Groves; Fiscal Year: 2002
    ....
  44. CELL GENESIS AND DIFFERENTIATION IN RETINA
    DAVID RAPAPORT; Fiscal Year: 2002
    ..Finally, understanding of the mechanism(s) of cell genesis and differentiation has important implications for tumorigenesis. ..
  45. Meeting: Development of the Spinal Cord and Neural Crest
    Marianne Bronner Fraser; Fiscal Year: 2002
    ....
  46. Conference on Wnt and Beta Catenin Signaling
    Randall Moon; Fiscal Year: 2002
    ..Given the explosive growth in research in this field owing to its connection to various cancers, it is extremely timely to have a meeting with the joint focus on the roles of Wnt and B-catenin signaling in both development and disease. ..
  47. Emerging Mechanisms of Epigenetic Regulation
    JEANNIE LEE; Fiscal Year: 2003
    ..Appreciate the agricultural implications of epigenetics, such as those relating to plant viral defense mechanisms, animal cloning, and imprinting. ..
  48. 2003/2005 INTERNATIONAL C. ELEGANS MEETINGS
    Geraldine Seydoux; Fiscal Year: 2004
    ..Previous C. elegans meetings have led to the exchange of knowledge, ideas, methods, mutants, and clones and have been vital in fostering the sense of excitement and the collegiality and cooperativity that characterize this field. ..
  49. MOLECULAR BASIS OF NEUROGENESIS IN VERTEBRATE EMBRYOS
    Christopher Kintner; Fiscal Year: 2004
    ..These experiments will provide new information about how neural stem cells form in embyros, and how the differentiation of these cells is controlled to generate the neurons that make up the vertebrate central nervous system. ..
  50. Regulation of Parietal Endoderm Migration
    Laura Grabel; Fiscal Year: 2006
    ..We will therefore examine PE outgrowth on Matrigel, plus and minus fibronectin, with a particular focus on examining the role of integrins in promoting directed versus random migration. [unreadable] [unreadable] [unreadable]..
  51. FUNCTION OF NOGGIN IN HAIR FOLLICLE GROWTH AND DISEASE
    Vladimir Botchkarev; Fiscal Year: 2006
    ....
  52. NEURONAL LINEAGE DETERMINANTS IN EMBRYOS
    SALLY MOODY; Fiscal Year: 2006
    ..abstract_text> ..
  53. Dermal Bone Growth in the Zebrafish
    MARY IOVINE; Fiscal Year: 2006
    ..By completing these aims, this proposal will provide new insights of direct relevance for understanding the biology of human malformations. ..
  54. Genetic Analysis of Silurana Tropicalis Development
    Richard Harland; Fiscal Year: 2005
    ..We will carry out a genetic screen, map deletions cytologically, and optimize insertional mutagenesis. ..
  55. Cell polarity and the cell cycle in C. elegans.
    Morgan Goulding; Fiscal Year: 2005
    ..This project aims to shed light on basic mechanisms of animal cells, in particular those modulating rates of DNA replication and cytoplasmic reorganization. ..
  56. Molecular Regulation of Lacrimal Gland Branching
    Richard Lang; Fiscal Year: 2005
    ..Combined, these will provide a focussed effort designed to answer questions central to the mechanism of lacrimal gland development and may provide an understanding of how to approach treatment of the dry eye condition. ..
  57. NEURAL TUBE DEFECTS
    DAVID MC CLAY; Fiscal Year: 2005
    ..abstract_text> ..
  58. Genetic Analysis of Maternal Factors in Embryonic Devel*
    Mary Mullins; Fiscal Year: 2005
    ..These studies will be relevant to the nature of human sterilities, birth defects, and human inherited disorders. ..
  59. Gene Expression Analysis in Microcaptured Retinal Cells
    Ruben Adler; Fiscal Year: 2005
    ..The potential impact of the identification of these molecules is clear, since they could offer new avenues for the treatment of these devastating diseases. ..
  60. CELL CELL INTERACTIONS IN PROSTATE CANCER
    Gerald Cunha; Fiscal Year: 2001
    ..These studies should define critical cellular and molecular pathways in both normal and tumorigenic growth of the prostate, and should provide the biological basis of new therapeutic strategies. ..