chemotaxis

Summary

Summary: The movement of cells or organisms toward or away from a substance in response to its concentration gradient.

Top Publications

  1. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
  2. pmc Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis
    Congying Wu
    Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Cell 148:973-87. 2012
  3. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
  4. ncbi Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity
    Kristen F Swaney
    Department of Cell Biology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Biophys 39:265-89. 2010
  5. ncbi The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes
    Karl Balabanian
    Unite d Immunologie Virale, Institut Pasteur, 75015 Paris, France
    J Biol Chem 280:35760-6. 2005
  6. ncbi Rapid leukocyte migration by integrin-independent flowing and squeezing
    Tim Lämmermann
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Nature 453:51-5. 2008
  7. ncbi CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion
    Magda Kucia
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    J Mol Histol 35:233-45. 2004
  8. ncbi Genetic analysis of Escherichia coli biofilm formation: roles of flagella, motility, chemotaxis and type I pili
    L A Pratt
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA
    Mol Microbiol 30:285-93. 1998
  9. pmc Collective chemotaxis requires contact-dependent cell polarity
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Dev Cell 19:39-53. 2010
  10. pmc Chemotaxis in cancer
    Evanthia T Roussos
    Department of Anatomy and Structural Biology, Program in Tumor Microenvironment and Metastasis, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Nat Rev Cancer 11:573-87. 2011

Detail Information

Publications344 found, 100 shown here

  1. ncbi Involvement of chemokine receptors in breast cancer metastasis
    A Muller
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, USA
    Nature 410:50-6. 2001
    ..Our findings indicate that chemokines and their receptors have a critical role in determining the metastatic destination of tumour cells...
  2. pmc Arp2/3 is critical for lamellipodia and response to extracellular matrix cues but is dispensable for chemotaxis
    Congying Wu
    Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    Cell 148:973-87. 2012
    ..respond normally to shallow gradients of PDGF, indicating that lamellipodia are not required for fibroblast chemotaxis. Conversely, these cells cannot respond to a surface-bound gradient of extracellular matrix (haptotaxis)...
  3. ncbi Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Y R Zou
    Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York 10016, USA
    Nature 393:595-9. 1998
    ..These results may be important for designing strategies to block HIV entry into cells and for understanding mechanisms of pathogenesis in AIDS dementia...
  4. ncbi Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity
    Kristen F Swaney
    Department of Cell Biology, Johns Hopkins University, School of Medicine, Baltimore, Maryland 21205, USA
    Annu Rev Biophys 39:265-89. 2010
    b>Chemotaxis, the directed migration of cells in chemical gradients, is a vital process in normal physiology and in the pathogenesis of many diseases. Chemotactic cells display motility, directional sensing, and polarity...
  5. ncbi The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes
    Karl Balabanian
    Unite d Immunologie Virale, Institut Pasteur, 75015 Paris, France
    J Biol Chem 280:35760-6. 2005
    ..We demonstrate that RDC1 is expressed in T lymphocytes and that CXCL12-promoted chemotaxis is inhibited by an anti-RDC1 monoclonal antibody...
  6. ncbi Rapid leukocyte migration by integrin-independent flowing and squeezing
    Tim Lämmermann
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Nature 453:51-5. 2008
    ..We studied the interplay between adhesive, contractile and protrusive forces during interstitial leukocyte chemotaxis in vivo and in vitro...
  7. ncbi CXCR4-SDF-1 signalling, locomotion, chemotaxis and adhesion
    Magda Kucia
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    J Mol Histol 35:233-45. 2004
    ..In this review, we focus on a role of the SDF-1-CXCR4 axis in regulating the metastatic behaviour of tumour cells and discuss the molecular mechanisms that are essential to this process...
  8. ncbi Genetic analysis of Escherichia coli biofilm formation: roles of flagella, motility, chemotaxis and type I pili
    L A Pratt
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA
    Mol Microbiol 30:285-93. 1998
    ..Using defined fli, flh, mot and che alleles, we show that motility, but not chemotaxis, is critical for normal biofilm formation...
  9. pmc Collective chemotaxis requires contact-dependent cell polarity
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Dev Cell 19:39-53. 2010
    ....
  10. pmc Chemotaxis in cancer
    Evanthia T Roussos
    Department of Anatomy and Structural Biology, Program in Tumor Microenvironment and Metastasis, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York 10461, USA
    Nat Rev Cancer 11:573-87. 2011
    b>Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an essential component of tumour dissemination during progression and metastasis...
  11. pmc Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway
    Kosuke Takeda
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    Sci Signal 5:ra2. 2012
    ..after a change in the input, often involves negative feedback loops and plays a crucial role in eukaryotic chemotaxis. We determined the dynamical response to a uniform change in chemoattractant concentration of a eukaryotic ..
  12. pmc Mesenchymal stem cells secrete multiple cytokines that promote angiogenesis and have contrasting effects on chemotaxis and apoptosis
    Robert A Boomsma
    Department of Biology, Trinity Christian College, Palos Heights, Illinois, United States of America
    PLoS ONE 7:e35685. 2012
    ..It is likely that multiple pro-survival factors in addition to MCP-1 are secreted by MSC which act on divergent intracellular signaling pathways...
  13. pmc Bacterial chemoreceptor arrays are hexagonally packed trimers of receptor dimers networked by rings of kinase and coupling proteins
    Ariane Briegel
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 109:3766-71. 2012
    ..transmembrane machines of unknown structure that allow bacteria to sense their surroundings and respond by chemotaxis. We have combined X-ray crystallography of purified proteins with electron cryotomography of native arrays ..
  14. ncbi Mesenchymal stem cell homing: the devil is in the details
    Jeffrey M Karp
    Harvard MIT Division of Health Science and Technology, 77 Massachusetts Avenue, E25 519, Cambridge, MA 02139, USA
    Cell Stem Cell 4:206-16. 2009
    ..This review provides a critical analysis of the methods used to track homing of exogenously infused MSCs and discusses strategies for enhancing their trafficking to particular tissues...
  15. ncbi Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling
    Jacqueline D Shields
    Institute of Bioengineering, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne 1015, Switzerland
    Cancer Cell 11:526-38. 2007
    ..Under static conditions, lymphatic endothelium induced CCR7-dependent chemotaxis of tumor cells through 3D matrices...
  16. ncbi Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation
    E Hirsch
    Department of Genetics, Biology and Biochemistry, University of Torino, Turin, Italy
    Science 287:1049-53. 2000
    ..These results demonstrate that PI3Kgamma is a crucial signaling molecule required for macrophage accumulation in inflammation...
  17. ncbi CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
    Jan A Burger
    Department of Leukemia, Unit 428, The University of Texas M D Anderson Cancer Center, PO Box 301402, Houston, TX 77230 1402, USA
    Blood 107:1761-7. 2006
    ..As such, CXCR4 antagonists, although initially developed for treatment of AIDS, actually may become effective agents for the treatment of neoplastic disease...
  18. ncbi Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    Peter Staller
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nature 425:307-11. 2003
    ....
  19. ncbi Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors
    Marek Honczarenko
    Joint Program in Transfusion Medicine, Children s Hospital Boston, Harvard Medical School, Karp Family Research Bldg, RB10217, 1 Blackfan Circle, Boston, Massachusetts 02115, USA
    Stem Cells 24:1030-41. 2006
    ..In cell biologic assays, all of the chemokines tested stimulate chemotaxis of BMSCs, and CXCL12 induces cytoskeleton F-actin polymerization...
  20. ncbi G protein signaling events are activated at the leading edge of chemotactic cells
    C A Parent
    Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell 95:81-91. 1998
    ....
  21. ncbi Chemotaxis in the absence of PIP3 gradients
    Oliver Hoeller
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Curr Biol 17:813-7. 2007
    ..There is, however, a consistent defect in movement speed in chemotaxis and especially in random movement...
  22. ncbi Motility and chemotaxis in Campylobacter and Helicobacter
    Paphavee Lertsethtakarn
    Department of Microbiology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California 95064, USA
    Annu Rev Microbiol 65:389-410. 2011
    ..To mediate chemotaxis, C. jejuni and H. pylori combine basic chemotaxis signal transduction components with several accessory proteins...
  23. pmc The c-di-GMP binding protein YcgR controls flagellar motor direction and speed to affect chemotaxis by a "backstop brake" mechanism
    Koushik Paul
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Mol Cell 38:128-39. 2010
    ..Inhibition of motility and chemotaxis may represent a strategy to prepare for sedentary existence by disfavoring migration away from a substrate on ..
  24. ncbi Trafficking of normal stem cells and metastasis of cancer stem cells involve similar mechanisms: pivotal role of the SDF-1-CXCR4 axis
    Magda Kucia
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Stem Cells 23:879-94. 2005
    ....
  25. ncbi Parallels between tissue repair and embryo morphogenesis
    Paul Martin
    Department of Physiology, University of Bristol, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Development 131:3021-34. 2004
    ..In the embryo, both morphogenesis and repair are achieved with a perfect end result, whereas repair of adult tissues leads to scarring. We discuss whether this may be due to the adult inflammatory response, which is absent in the embryo...
  26. ncbi Signal processing in complex chemotaxis pathways
    Steven L Porter
    Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, Devon EX4 4QD, UK
    Nat Rev Microbiol 9:153-65. 2011
    Bacteria use chemotaxis to migrate towards environments that are better for growth. Chemoreceptors detect changes in attractant levels and signal through two-component systems to control swimming direction...
  27. ncbi Fibroblast growth factor signaling during early vertebrate development
    Ralph T Böttcher
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Endocr Rev 26:63-77. 2005
    ..growth factors (FGFs) have been implicated in diverse cellular processes including apoptosis, cell survival, chemotaxis, cell adhesion, migration, differentiation, and proliferation...
  28. ncbi Tumor suppressor PTEN mediates sensing of chemoattractant gradients
    Miho Iijima
    Department of Cell Biology, Johns Hopkins University, School of Medicine, 21205, Baltimore, MD, USA
    Cell 109:599-610. 2002
    ..Membrane localization required a putative PI(4,5)P2 binding motif and was required for chemotaxis. These results suggest that specific phosphoinositides direct actin polymerization to the cell's leading edge ..
  29. ncbi Functional interactions between receptors in bacterial chemotaxis
    Victor Sourjik
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 428:437-41. 2004
    Bacterial chemotaxis is a model system for signal transduction, noted for its relative simplicity, high sensitivity, wide dynamic range and robustness...
  30. ncbi Identification of a testicular odorant receptor mediating human sperm chemotaxis
    Marc Spehr
    Department of Cell Physiology, Ruhr University Bochum, 150 University Street, D 44780 Bochum, Germany
    Science 299:2054-8. 2003
    ..In contrast, undecanal was a potent OR antagonist to bourgeonal and related compounds. Taken together, these results indicate that hOR17-4 functions in human sperm chemotaxis and may be a critical component of the fertilization process.
  31. pmc Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis
    Zubair Shah
    Davis Heart and Lung Research Institute, 473 W 12th Avenue, Columbus, OH 43210, USA
    Circulation 124:2338-49. 2011
    ..Because DPP-4 is expressed in inflammatory cells, we hypothesized that its inhibition will exert favorable effects in atherosclerosis...
  32. ncbi The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities
    Adriana López Ponte
    Laboratoire d Hématopoïèse, Institut National de la Santé et de la Recherche Médicale ER15, IFR135 Université François Rebelais, Tours, France
    Stem Cells 25:1737-45. 2007
    ..Our results suggest that the mobilization of MSCs and their subsequent homing to injured tissues may depend on the systemic and local inflammatory state. Disclosure of potential conflicts of interest is found at the end of this article...
  33. ncbi The HAMP domain structure implies helix rotation in transmembrane signaling
    Michael Hulko
    Department of Protein Evolution, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Cell 126:929-40. 2006
    ..with intracellular signaling domains in over 7500 proteins, including histidine kinases, adenylyl cyclases, chemotaxis receptors, and phosphatases...
  34. pmc Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis
    Hidenori Hattori
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:3546-51. 2010
    Neutrophil chemotaxis plays an essential role in innate immunity, but the underlying cellular mechanism is still not fully characterized...
  35. pmc Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells
    Sabina A Islam
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 12:167-77. 2011
    ..In humans, CCR8 expression also defined an IL-5-enriched T(H)2 cell subset. The CCL8-CCR8 chemokine axis is therefore a crucial regulator of T(H)2 cell homing that drives IL-5-mediated chronic allergic inflammation...
  36. pmc Responding to chemical gradients: bacterial chemotaxis
    Victor Sourjik
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, DKFZ ZMBH Alliance, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany
    Curr Opin Cell Biol 24:262-8. 2012
    b>Chemotaxis allows bacteria to follow gradients of nutrients and other environmental stimuli...
  37. pmc Cells navigate with a local-excitation, global-inhibition-biased excitable network
    Yuan Xiong
    Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 107:17079-86. 2010
    ..Our study brings together heretofore diverse observations on spontaneous cytoskeletal activity, signaling responses to temporal stimuli, and spatial gradient sensing into a unified scheme...
  38. pmc Adaptation at the output of the chemotaxis signalling pathway
    Junhua Yuan
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 484:233-6. 2012
    In the bacterial chemotaxis network, receptor clusters process input, and flagellar motors generate output. Receptor and motor complexes are coupled by the diffusible protein CheY-P...
  39. ncbi Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: next-generation chemokine therapy for therapeutic neovasculariz
    Ken ichi Hiasa
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Circulation 109:2454-61. 2004
    ..We therefore hypothesized that SDF-1alpha gene transfer would induce therapeutic neovascularization in vivo by functioning as a chemokine of EPC...
  40. pmc High-throughput behavioral analysis in C. elegans
    Nicholas A Swierczek
    Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, Virginia, USA
    Nat Methods 8:592-8. 2011
    ..paradigms using this system: spontaneous movement on food, where the behavior changes over tens of minutes; chemotaxis, where turning events must be detected accurately to determine strategy; and habituation of response to tap, ..
  41. ncbi BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells
    Gamal Badr
    Service of Immuno Virology, Commissariat a l Energie Atomique, Departement des Sciences du Vivant, Institut des Maladies Emergentes et Thérapies Innovantes, Unité Mixte de Recherche E1, Universite Paris Sud, Orsay, France
    Blood 111:2744-54. 2008
    ..The BAFF-induced increase in B-cell chemotaxis was totally abolished by blockade of BAFF-R and was strongly dependent on the activation of PI3K/AKT, NF-kappaB, ..
  42. pmc External and internal constraints on eukaryotic chemotaxis
    Danny Fuller
    Cell and Developmental Biology, Division of Biological Sciences, Department of Physics, and Center for Theoretical Biological Physics, University of California, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 107:9656-9. 2010
    b>Chemotaxis, the chemically guided movement of cells, plays an important role in several biological processes including cancer, wound healing, and embryogenesis...
  43. ncbi CD38 orchestrates migration, survival, and Th1 immune response of human mature dendritic cells
    Loredana Frasca
    Department of Infectious, Parasitic, and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    Blood 107:2392-9. 2006
    ..The results indicate the following: (1) CD38 engagement in MDDCs ensures efficient chemotaxis and transendothelial migration driven by CC chemokine ligand 21 (CCL21); (2) CD38 is laterally associated with ..
  44. pmc PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis
    Yoichiro Kamimura
    Department of Cell Biology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    Curr Biol 18:1034-43. 2008
    ..3,4,5-trisphosphate (PIP(3)) promotes cytoskeletal rearrangements and alters cell motility and chemotaxis, possibly through activation of protein kinase Bs (PKBs)...
  45. ncbi A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow
    Robert F Wynn
    Stem Cell Research Group and Willink Biochemical Genetics Unit, Royal Manchester Children s Hospital, Manchester, United Kingdom
    Blood 104:2643-5. 2004
    ..We show that CXCR4, although present at the surface of a small subset of MSCs, is important for mediating specific migration of these cells to bone marrow...
  46. pmc Going against the grain: chemotaxis and infection in Vibrio cholerae
    Susan M Butler
    Tufts University School of Medicine, Department of Molecular Biology and Microbiology, 136 Harrison Avenue, Boston, Massachusetts 02111, USA
    Nat Rev Microbiol 3:611-20. 2005
    b>Chemotaxis is the process by which motile cells move in a biased manner both towards favourable and away from unfavourable environments...
  47. pmc 5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis
    Wenjuan Su
    Departments of Biochemistry Pharmacology, Center for Developmental Genetics, Brook University, Stony Brook, New York, USA
    Mol Pharmacol 75:437-46. 2009
    ..implicated in many cell biological processes, including Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking...
  48. ncbi Signal transduction by the chemokine receptor CXCR3: activation of Ras/ERK, Src, and phosphatidylinositol 3-kinase/Akt controls cell migration and proliferation in human vascular pericytes
    A Bonacchi
    Dipartimento di Medicina Interna, University of Florence, Italy
    J Biol Chem 276:9945-54. 2001
    ..In HSC, interaction of CXCR3 with its ligands resulted in increased chemotaxis and activation of the Ras/ERK cascade...
  49. ncbi Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish
    Jonathan R Mathias
    University of Wisconsin Madison, 2715 Medical Sciences Center, 1300 University Ave, Madison, WI 53706, USA
    J Leukoc Biol 80:1281-8. 2006
    Neutrophil chemotaxis to sites of inflammation is a critical process during normal immune responses to tissue injury and infection and pathological immune responses leading to chronic inflammation...
  50. ncbi CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion
    Jolanta Libura
    Stem Cell Biology Program at the James Graham Brown Cancer Center, University of Louisville, KY 40202, USA
    Blood 100:2597-606. 2002
    ..several of them (1) phosphorylation of mitogen-activated protein kinase p42/44; (2) locomotion; (3) directional chemotaxis across membranes covered by laminin, fibronectin, or Matrigel; (4) adhesion to laminin, fibronectin, and ..
  51. ncbi Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease
    J Rogers
    L J Roberts Center for Alzheimer s Research, Sun Health Research Institute, P O Box 1278, 10515 West Santa Fe Drive, Sun City, AZ 85372, USA
    Neurochem Int 39:333-40. 2001
    ..Because AD microglial chemotaxis, phagocytosis, and secretory activity have common, tightly linked soluble intermediaries (e.g...
  52. ncbi CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis
    Lucy A Truman
    Medical Research Council MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    Blood 112:5026-36. 2008
    ..Effective chemotaxis of macrophages to apoptotic lymphocytes is dependent on macrophage fractalkine receptor, CX3CR1...
  53. ncbi Chemotaxis in shallow gradients is mediated independently of PtdIns 3-kinase by biased choices between random protrusions
    Natalie Andrew
    School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK
    Nat Cell Biol 9:193-200. 2007
    Current models of eukaryotic chemotaxis propose that directional sensing causes localized generation of new pseudopods...
  54. pmc Bacterial chemoreceptors: high-performance signaling in networked arrays
    Gerald L Hazelbauer
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65211, USA
    Trends Biochem Sci 33:9-19. 2008
    Chemoreceptors are crucial components in the bacterial sensory systems that mediate chemotaxis. Chemotactic responses exhibit exquisite sensitivity, extensive dynamic range and precise adaptation...
  55. pmc The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis
    Huan Yang
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    J Leukoc Biol 93:865-73. 2013
    ..HMGB1 can be extracellularly released, where it mediates activation of innate immune responses, including chemotaxis and cytokine release...
  56. ncbi A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis
    T Yokomizo
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Japan
    Nature 387:620-4. 1997
    ..Our findings, together with previous reports, show that LTB4 is a unique lipid mediator that interacts with both cell-surface and nuclear receptors...
  57. pmc Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis
    Huaqing Cai
    Department of Cell Biology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA
    J Cell Biol 190:233-45. 2010
    ..activation and actin polymerization are extended, pseudopodial activity is increased and mislocalized, and chemotaxis is impaired. The effects of activated RasC are suppressed by deletion of the TORC2 subunit PiaA...
  58. ncbi A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis
    Jianshe Yan
    Chemotaxis Signal Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA
    Dev Cell 22:92-103. 2012
    ..During chemotaxis, Gβγ subunits regulate actin assembly and migration, but the protein(s) linking Gβγ to the actin ..
  59. pmc An improved chamber for direct visualisation of chemotaxis
    Andrew J Muinonen-Martin
    CRUK Beatson Institute for Cancer Research, Glasgow, United Kingdom
    PLoS ONE 5:e15309. 2010
    There has been a growing appreciation over the last decade that chemotaxis plays an important role in cancer migration, invasion and metastasis...
  60. pmc Chemotaxis of cell populations through confined spaces at single-cell resolution
    Ziqiu Tong
    Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 7:e29211. 2012
    ..Our novel microfluidic design is therefore a powerful tool for the study of cellular chemotaxis, and is suitable for a wide range of biological and biomedical applications.
  61. pmc The unique paradigm of spirochete motility and chemotaxis
    Nyles W Charon
    Department of Microbiology, Immunology, and Cell Biology, West Virginia University, Health Sciences Center, Morgantown, 26506 9177, USA
    Annu Rev Microbiol 66:349-70. 2012
    ..Borrelia burgdorferi (Bb) as a model system, we explore the current research on spirochete motility and chemotaxis. Bb has periplasmic flagella (PFs) subterminally attached to each end of the protoplasmic cell cylinder, and ..
  62. pmc Biased excitable networks: how cells direct motion in response to gradients
    Pablo A Iglesias
    Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, United States
    Curr Opin Cell Biol 24:245-53. 2012
    ..In this review, we discuss some of these observations and theories proposed to explain them. We also suggest a mechanism for cell polarity that can be incorporated into the existing framework...
  63. ncbi Akirin1 (Mighty), a novel promyogenic factor regulates muscle regeneration and cell chemotaxis
    Mônica Senna Salerno
    Functional Muscle Genomics, AgResearch, Hamilton, New Zealand
    Exp Cell Res 315:2012-21. 2009
    ..addition to SC, macrophages also express akirin1, and increased expression of akirin1 resulted in more efficient chemotaxis of both macrophages and myoblasts...
  64. pmc Active sampling and decision making in Drosophila chemotaxis
    Alex Gomez-Marin
    EMBL CRG Systems Biology Unit, Center for Genomic Regulation CRG and UPF, 08003 Barcelona, Spain
    Nat Commun 2:441. 2011
    ..Here we show that chemotaxis in Drosophila melanogaster larvae is an active sampling process analogous to sniffing in vertebrates...
  65. pmc Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release
    Adriana Sumoza-Toledo
    Laboratory of Cell and Molecular Signaling, Center for Biomedical Research, Queen s Medical Center, Honolulu, Hawaii, USA
    FASEB J 25:3529-42. 2011
    Chemokines induce calcium (Ca(2+)) signaling and chemotaxis in dendritic cells (DCs), but the molecular players involved in shaping intracellular Ca(2+) changes remain to be characterized...
  66. ncbi CXCR7 mediated Giα independent activation of ERK and Akt promotes cell survival and chemotaxis in T cells
    Romsha Kumar
    Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Cell Immunol 272:230-41. 2012
    ..Selective inhibition of each signal demonstrated that phosphorylated ERK 1/2 is essential for chemotaxis and survival of T cells whereas activation of Akt promotes only cell survival...
  67. pmc Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis
    Puneet S Jolly
    Department of Biochemistry, Virginia Commonwealth University Medical Center, Richmond 23298, USA
    J Exp Med 199:959-70. 2004
    ..of SphK blocks FcepsilonRI-mediated internalization of these receptors and markedly reduces degranulation and chemotaxis. Although transactivation of S1P1 and Gi signaling are important for cytoskeletal rearrangements and migration ..
  68. pmc β1 integrins regulate fibroblast chemotaxis through control of N-WASP stability
    Samantha J King
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunts House, Guys Campus, London, UK
    EMBO J 30:1705-18. 2011
    ..Here, we demonstrate that β1 integrins are required both for fibroblast chemotaxis towards platelet-derived growth factor (PDGF) and growth factor-induced dorsal ruffling...
  69. ncbi Dictyostelium discoideum chemotaxis: threshold for directed motion
    Loling Song
    Laboratory of Atomic and Solid State Physics, Department of Physics, Cornell University, Ithaca, NY 14853, USA
    Eur J Cell Biol 85:981-9. 2006
    ..In the regime of optimal response the difference in receptor occupancy at the front and back of the cell is estimated to be only about 100 molecules...
  70. ncbi Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1
    G A McQuibban
    Department of Biochemistry and Molecular Biology, Oral Biological and Medical Sciences, Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 276:43503-8. 2001
    ..These data suggest that MMPs may be important regulatory proteases in attenuating SDF-1 function and point to a deep convergence of two important networks, chemokines and MMPs, to regulate leukocytic activity in vivo...
  71. pmc Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages
    Athanassios Dovas
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Sci 122:3873-82. 2009
    ..adhesion structures capable of matrix degradation, have been linked with the ability of cells to perform chemotaxis and invade tissues...
  72. ncbi Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets
    Valeria Sordi
    Telethon Juvenile Diabetes Research Foundation Center for Beta Cell Replacement, H S Raffaele Telethon Institute for Gene Therapy, and Renal Pathophysiology Laboratory, Division of Medicine, Via Olgettina 60, 20132 Milan, Italy
    Blood 106:419-27. 2005
    ..This study defines the chemokine receptor repertoire of human BM-MSCs that determines their migratory activity. Modulation of homing capacity may be instrumental for harnessing the therapeutic potential of BM-MSCs...
  73. ncbi Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors
    S Honda
    Department of Neurochemistry, National Institute of Neuroscience, 4-1-1 Ogawa-higashi, Kodaira, Tokyo 187-8502, Japan
    J Neurosci 21:1975-82. 2001
    ..Further analyses using the Dunn chemotaxis chamber assay, which allows direct observation of cell movement, revealed that both ATP and ADP induced ..
  74. ncbi Flagella-driven chemotaxis towards exudate components is an important trait for tomato root colonization by Pseudomonas fluorescens
    Sandra de Weert
    Leiden University, Institute of Molecular Plant Sciences, The Netherlands
    Mol Plant Microbe Interact 15:1173-80. 2002
    ..To test the hypothesis that this role of motility is based on chemotaxis toward exudate components, cheA mutants that were defective in flagella-driven chemotaxis but retained motility ..
  75. ncbi LPA2 (EDG4) mediates Rho-dependent chemotaxis with lower efficacy than LPA1 (EDG2) in breast carcinoma cells
    Min Chen
    Department of Surgery, University of Texas Medical Branch, 301 Univ Blvd, Galveston, TX 77555 0525, USA
    Am J Physiol Cell Physiol 292:C1927-33. 2007
    ..LPA3 expression was detected primarily in MDA-MB-157 cells. Using a Transwell chemotaxis assay to monitor dose response, we find that cells predominantly expressing LPA1 have a peak migration rate at ..
  76. ncbi Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6
    D Yang
    Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Intramural Research Support Program, SAIC Frederick, National Cancer Institute Frederick Cancer Research and Development Center, Frederick, MD 21702 1201, USA
    Science 286:525-8. 1999
    ..The beta-defensin-induced chemotaxis was sensitive to pertussis toxin and inhibited by antibodies to CCR6...
  77. pmc Origins and diversification of a complex signal transduction system in prokaryotes
    Kristin Wuichet
    BioEnergy Science Center and Computer Science and Mathematics Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
    Sci Signal 3:ra50. 2010
    The molecular machinery that controls chemotaxis in bacteria is substantially more complex than any other signal transduction system in prokaryotes, and its origins and variability among living species are unknown...
  78. pmc A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration
    Pascale G Charest
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0380, USA
    Dev Cell 18:737-49. 2010
    Ras was found to regulate Dictyostelium chemotaxis, but the mechanisms that spatially and temporally control Ras activity during chemotaxis remain largely unknown...
  79. ncbi Adaptation in the chemotactic guidance of nerve growth cones
    Guo li Ming
    Division of Biology, University of California at San Diego, La Jolla, California 92093, USA
    Nature 417:411-8. 2002
    ..Analogous to the process of chemotaxis in microorganisms, we found that axonal growth cones of cultured Xenopus spinal neurons exhibit adaptation ..
  80. pmc Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected]
    Marianna Penzo
    Vita Salute San Raffaele University, School of Medicine, San Raffaele Scientific Institute, Milano, Italy
    J Immunol 184:4497-509. 2010
    ..We show that IKKalpha and IKKbeta are each critically important for HMGB1-elicited chemotaxis of fibroblasts, macrophages, and neutrophils in vitro and neutrophils in vivo...
  81. ncbi Understanding eukaryotic chemotaxis: a pseudopod-centred view
    Robert H Insall
    Beatson Institute for Cancer Research, Bearsden, Glasgow G61 1BD, UK
    Nat Rev Mol Cell Biol 11:453-8. 2010
    Current descriptions of eukaryotic chemotaxis and cell movement focus on how extracellular signals (chemoattractants) cause new pseudopods to form...
  82. ncbi Like cops on the beat: the active role of resting microglia
    Gennadij Raivich
    Perinatal Brain Repair Group, Department of Anatomy, Obstetrics and Gynaecology, University College London, Chenies Mews 86 96, London WC1E 6HX, UK
    Trends Neurosci 28:571-3. 2005
    ..These moving branches show a rapid chemotactic response to tissue injury that depends on purine receptors and connexin hemichannels, and they appear to take cues from surrounding astrocytes both in the normal and the injured brain...
  83. pmc Self-organization of the Escherichia coli chemotaxis network imaged with super-resolution light microscopy
    Derek Greenfield
    Biophysics Graduate Group, University of California Berkeley, Berkeley, California, United States of America
    PLoS Biol 7:e1000137. 2009
    The Escherichia coli chemotaxis network is a model system for biological signal processing. In E. coli, transmembrane receptors responsible for signal transduction assemble into large clusters containing several thousand proteins...
  84. ncbi An autoregulatory circuit for long-range self-organization in Dictyostelium cell populations
    Satoshi Sawai
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 433:323-6. 2005
    Nutrient-deprived Dictyostelium amoebae aggregate to form a multicellular structure by chemotaxis, moving towards propagating waves of cyclic AMP that are relayed from cell to cell...
  85. pmc Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma
    Yazan Alsayed
    University of Pittsburgh Cancer Institute, Division of Hematology Oncology, Department of Internal Medicine, University of Pittsburgh, PA, USA
    Blood 109:2708-17. 2007
    ..This study, therefore, demonstrates that SDF-1/CXCR4 is a critical regulator of MM homing and that it provides the framework for inhibitors of this pathway to be used in future clinical trials to abrogate MM trafficking...
  86. ncbi SDF-1/CXCL12 enhances survival and chemotaxis of murine embryonic stem cells and production of primitive and definitive hematopoietic progenitor cells
    Ying Guo
    Department of Microbiology, Indiana University School of Medicine, 1044 West Walnut Street, R4 302, Indianapolis, Indiana 46202, USA
    Stem Cells 23:1324-32. 2005
    ..Furthermore, SDF-1/CXCL12 induced chemotaxis of ESCs, and chemotaxis could be enhanced by diprotin A inhibition of CD26/dipeptidylpeptidase IV...
  87. pmc The cyclase-associated protein CAP as regulator of cell polarity and cAMP signaling in Dictyostelium
    Angelika A Noegel
    Center for Biochemistry, Medical Faculty, University of Cologne, 50931 Cologne, Germany
    Mol Biol Cell 15:934-45. 2004
    ..The data suggest an interaction of CAP with adenylyl cyclase in Dictyostelium and an influence on signaling pathways directly as well as through its function as a regulatory component of the cytoskeleton...
  88. pmc Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19
    Ulrike Haessler
    Institute of Bioengineering, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 108:5614-9. 2011
    ..Despite the importance of DC chemotaxis, it is not well understood how DCs interpret gradients of these chemokines in a complex 3D microenvironment...
  89. pmc Chemotaxis to the quorum-sensing signal AI-2 requires the Tsr chemoreceptor and the periplasmic LsrB AI-2-binding protein
    Manjunath Hegde
    3122 TAMU, Texas A and M University, College Station, TX 77843 3122, USA
    J Bacteriol 193:768-73. 2011
    ..We show that AI-2 strongly attracts Escherichia coli. Both LsrB and Tsr are necessary for sensing AI-2, but AI-2 uptake is not, suggesting that LsrB and Tsr interact directly in the periplasm...
  90. pmc Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour
    Matthew P Neilson
    Cancer Research UK Beatson Institute, Glasgow, United Kingdom
    PLoS Biol 9:e1000618. 2011
    The mechanism of eukaryotic chemotaxis remains unclear despite intensive study. The most frequently described mechanism acts through attractants causing actin polymerization, in turn leading to pseudopod formation and cell movement...
  91. ncbi Behavioral response of human spermatozoa to a concentration jump of chemoattractants or intracellular cyclic nucleotides
    Anna Gakamsky
    Department of Biological Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel
    Hum Reprod 24:1152-63. 2009
    A major question in mammalian sperm chemotaxis is whether the cells sense a chemoattractant gradient by comparing the chemoattractant concentration between time points or between spatial points.
  92. ncbi ZBP1 enhances cell polarity and reduces chemotaxis
    Kyle Lapidus
    Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461 1975, USA
    J Cell Sci 120:3173-8. 2007
    ..ZBP1 leads to these two apparently contradictory aspects of cell behavior--increased cell motility but decreased chemotaxis--we examined cell motility in detail, both in cell culture and in vivo in tumors...
  93. pmc Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis
    Gamal Badr
    Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia
    PLoS ONE 6:e23741. 2011
    ..The mechanisms responsible for the chemotaxis of malignant plasma cells are still poorly understood...
  94. pmc Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts
    Linda Schneider
    Department of Biology, Section of Cell and Developmental Biology, The August Krogh Building, University of Copenhagen, DK 2100 Copenhagen OE, Denmark
    Cell Physiol Biochem 25:279-92. 2010
    ..healing assays revealed that in ORPK mouse (IFT88(Tg737Rpw)) fibroblasts, where ciliary assembly is defective, chemotaxis towards PDGF-AA is absent, leading to unregulated high speed and uncontrolled directional cell displacement ..
  95. pmc Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-{gamma}
    Raju C Reddy
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, USA
    Blood 112:4250-8. 2008
    ..Sepsis is associated with impaired PMN function, including chemotaxis. PMNs express peroxisome proliferator-activated receptor-gamma (PPAR-gamma), a ligand-activated nuclear ..
  96. ncbi Adenylyl cyclase localization regulates streaming during chemotaxis
    Paul W Kriebel
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Building 37 Room 1E24, Bethesda, MD 20892, USA
    Cell 112:549-60. 2003
    We studied the role of the adenylyl cyclase ACA in Dictyostelium discoideum chemotaxis and streaming. In this process, cells orient themselves in a head to tail fashion as they are migrating to form aggregates...
  97. pmc A modular gradient-sensing network for chemotaxis in Escherichia coli revealed by responses to time-varying stimuli
    Thomas S Shimizu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Syst Biol 6:382. 2010
    The Escherichia coli chemotaxis-signaling pathway computes time derivatives of chemoeffector concentrations...
  98. ncbi Chemotaxis: finding the way forward with Dictyostelium
    Jason S King
    CRUK Beatson Institute, Bearsden, Glasgow, UK
    Trends Cell Biol 19:523-30. 2009
    ..and other intracellular messengers that connect signalling and migration, and the transition to models of chemotaxis driven by multiple, intertwined signalling pathways...
  99. ncbi A common mechanism of action for three mood-stabilizing drugs
    Robin S B Williams
    Intracellular Signalling Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London WC1E 6BT, UK
    Nature 417:292-5. 2002
    ..Inhibitors of prolyl oligopeptidase reverse the effects of all three drugs on sensory neuron growth cone area and collapse. These results suggest a molecular basis for both bipolar affective disorder and its treatment...
  100. ncbi Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1
    Ryan Reca
    Stem Cell Biology Program, University of Louisville, Louisville, KY 40202, USA
    Blood 101:3784-93. 2003
    ..of hematopoietic progenitors, it (1) potentiates the stromal cell-derived factor 1 (SDF-1)-dependent chemotaxis of human CD34(+) cells and lineage-committed myeloid, erythroid, and megakaryocytic progenitors; (2) primes SDF-..
  101. pmc Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells
    Lan Ma
    Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Biophys J 87:3764-74. 2004
    ..Finally, we use the model to predict the response of a cell where only a fraction is stimulated by a saturating dose of chemoattractant...

Research Grants68

  1. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..LPA and S1P regulate chemotaxis, stress responses, cytoskeletal organization, calcium signaling, cell survival, apoptosis, autophagy, and gene ..
  2. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..indicate that ECs are not only targets of DV infection, but release factors that potentiate immune cell chemotaxis and permeability of the infected endothelium...
  3. Analysis of gene regulation of Vibrio cholerae during infection
    Jun Zhu; Fiscal Year: 2013
    ..Our preliminary data indicate that AphB also regulates both RNS detoxification and chemotaxis, both processes central to the V. cholerae life cycle, in response to diverse stimuli...
  4. TARGETING THE MARCKS-FAMILY PROTEINS TO INHIBIT NEUTROPHIL MIGRATION
    Mary K Sheats; Fiscal Year: 2013
    ..specific aims are directed at understanding: (1) the requirement for MARCKS-family proteins in neutrophil chemotaxis toward intermediate (IL-8, LTB4) and end-stage (fMLP, C5a) chemoattractants;(2) the mechanism by which MARCKS-..
  5. Structural Basis for Chemokine Function
    Brian F Volkman; Fiscal Year: 2013
    ..Unexpectedly, our functional data revealed that SDF1 dimerization creates a potent inhibitor of chemotaxis. It is now clear that, while dimerization is essential for chemokine function in vivo, only chemokine monomers ..
  6. Targeting CC-Chemokine Receptor 7 for the prevention of graft-versus-host disease
    JAMES M COGHILL; Fiscal Year: 2013
    ..Lead compounds would next be evaluated for functionality by assessing their ability to impair chemotaxis (cellular movement) in vitro, a process that is mediated by CCR7...
  7. Human Beta-Defensin-1 in HSV-1 Innate Immunity
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..To begin to address the biological function of hBD-1, chemotaxis studies will be done...
  8. The Role of Vascular MR-Regulated Genes in Vascular Function and Disease
    Iris Z Jaffe; Fiscal Year: 2013
    ..of the vascular endothelial growth factor family and is known to promote vascular cell proliferation, monocyte chemotaxis, and inflammation by binding to the transmembrane receptor, fms-like tyrosine kinase (Flt-1)...
  9. Role of formyl peptide receptor variants in mucosal innate immune defense
    HEINI MARITA MIETTINEN; Fiscal Year: 2010
    ..FPR binds bacterial peptides with high affinity and results in neutrophil chemotaxis and bacterial killing through activation of the NADPH oxidase system...
  10. Conditional Knockout of Calcium Receptors in Bone Cells
    Dolores M Shoback; Fiscal Year: 2013
    ..changes in the [Ca2+]e affect expression of genes critical for matrix production and mineralization, chemotaxis, and proliferation...
  11. PLD2, as a GEF or as a Lipase, is Central to Leukocyte Chemotaxis
    JULIAN G CAMBRONERO; Fiscal Year: 2013
    ..Since the target, Rac2 Rho GTPase is responsible for cell movement PLD2 might be a major GEF mediating chemotaxis. Because GEFs are not constitutively active but are kept under tight regulation, we propose in AIM 1 to ..
  12. Fatty Acids, Eicosanoids and Inflammation
    Eric K Long; Fiscal Year: 2012
    ..Leukotrienes are important mediators of inflammation and chemotaxis of immune cells such as macrophages and T cells...
  13. DHA attenuates Inflammatory Responses Through Altering RAGE Signaling
    LYNETTE KAY ROGERS; Fiscal Year: 2013
    ..The central hypothesis is that DHA attenuates hyperoxia- induced lung injury by decreasing leukocyte chemotaxis, through altering RAGE expression and signaling pathways...
  14. MUCOSAL DEFENSE MECHANISMS IN SUBSTANCE ABUSE
    David R Brown; Fiscal Year: 2010
    ..In Specific Aim 3, we will characterize delta-opioid receptors mediating chemokine-induced chemotaxis of intestinal T lymphocytes, and determine the effects of opioids on neurally-mediated secretory immunoglobulin-..
  15. Suppression of pathogenic autoantibodies in lupus by inhibition of AID
    John D Mountz; Fiscal Year: 2012
    ..2) Does IL-17 regulate GC formation by up- regulation of RGS proteins? The ability of IL-17 to regulate chemotaxis will be determined in vitro using a Transwell chamber, Flow chamber live imaging analysis, and in vivo by ..
  16. Anthrax Toxins Impair Phagocyte Actin-based Motility
    Frederick Southwick; Fiscal Year: 2010
    ..We have found that PA + LF (50 ng/ml), called lethal toxin (LT), markedly impairs human neutrophil chemotaxis and chemoattractant-induced actin assembly...
  17. The Role of Carboxypeptidase B and its Substrates in Rheumatoid Arthritis
    William H Robinson; Fiscal Year: 2013
    ..These substrates are involved in inflammatory pathways including chemotaxis and T cell activation...
  18. Cyclic AMP Signaling in Pseudomonas aeruginosa Virulence
    Matthew C Wolfgang; Fiscal Year: 2011
    ..CyaB activity is positively regulated by components of the P. aeruginosa Type IV pilus chemotaxis system and negatively regulated by the alginate exopolysaccharide regulatory pathway...
  19. THE ROLE OF CELL SHAPE AND CELL WALL IN HELICOBACTER PYLORI PATHOGENESIS
    NINA REDA SALAMA; Fiscal Year: 2010
    ..tested show slight, but reproducible defects in halo formation in soft agar suggesting compromised swimming or chemotaxis. One vibrioid and two rod-shaped mutants were tested for their ability to colonize the mouse stomach and all ..
  20. Pososome Regulated Monocyte/Macrophage Tissue Infiltration
    Dianne Cox; Fiscal Year: 2013
    ..by a range of leukocytes including MDs to not only mediate matrix degradation but to also play a role in MD chemotaxis and tissue recruitment...
  21. Extracellular Matrix Remodeling During Aging
    JANE M SOTTILE; Fiscal Year: 2010
    ..FN fragments have been shown to regulate angiogenesis, cell migration, cell proliferation, and chemotaxis. It is not known whether changes in FN endocytosis occur during aging, or whether these changes result in the ..
  22. Role of Monocyte Chemoattractant Protein (MCP)-1 in Liver Regeneration
    KRISTEN ANDREA MITCHELL; Fiscal Year: 2010
    ..sinusoidal endothelial cells produce MCP-1, which functions through autocrine and paracrine pathways to promote chemotaxis and/or activation of nonparenchymal cells...
  23. Naturally Occurring IgM Anti-Leucocyte Autoantibodies Protect Against Renal IRI
    MARK DOUGLAS OKUSA; Fiscal Year: 2013
    ..cytokines (TNF-1, IL-2) but not others (IL-6 and IL-8), (ii) bind to chemokine receptors and inhibit chemotaxis. Based on these findings we questioned whether IgM- ALA downregulate inflammation that accompanies renal IRI...
  24. Inflammation and Cerebral Aneurysm Formation: Targets for Modulation and Vascular
    BRIAN LIM HOH; Fiscal Year: 2013
    ..Under the second aim, signaling mechanisms at each step of the leukocyte recruitment cascade: 1) chemotaxis, 2) rolling, 3) adhesion, 4) transmigration;will be blocked in an elastase saccular aneurysm model...
  25. Mechanisms of Pseudomonas Resistance to Membrane Permeabilization by SP-A
    Gee W Lau; Fiscal Year: 2012
    ..The defensive measures to be determined include increased LPS biosynthesis and modification, and chemotaxis evasion...
  26. Effect of Helicobacter pylori cell shape on pathogenesis
    LAURA ELIZABETH MARTINEZ; Fiscal Year: 2013
    ..H pylori express polar flagella on its surface, and both flagellar-based motility and chemotaxis are required for infection of the gastric mucosa 13-16. Helical cell shape is thought to enhance H...
  27. The Molecular Basis of Allorecognition in Social Amoeba
    Gad Shaulsky; Fiscal Year: 2013
    ..Aggregation involves chemotaxis to extracellular cAMP and Dictyostelium is one of the best model systems for the study of chemotaxis, which is a ..
  28. TGF-BETA, CHLORIDE CHANNELS AND MIGRATION OF EOSINOPHILS
    Devendra K Agrawal; Fiscal Year: 2012
    ..Under in vitro conditions, TGF-21 increased mRNA transcripts of ClC3 in eosinophils, and induced eosinophil chemotaxis, shape change, and transendothelial migration, which was inhibited by chloride channel blockers...
  29. Oncogenic Kit receptor signaling in vivo
    Peter Besmer; Fiscal Year: 2012
    ..and Src family kinase signaling in Kit mediated cell proliferation, suppression of apoptosis, cell adhesion, chemotaxis and secretory responses in vitro in bone marrow derived mast cells (BMMC)...
  30. Nitrite Mediated Cardioprotection
    DAVID JOSEPH LEFER; Fiscal Year: 2012
    ..These include vasodilation and the inhibition of oxidative stress, platelet aggregation, leukocyte chemotaxis and apoptosis...
  31. Fetal HCMV Infection: Role of the Human Placenta
    LENORE PALMA PEREIRA; Fiscal Year: 2013
    ..decidual LEC to identify molecular pathways that dysregulate integrins that function as downstream effectors of chemotaxis, migration and cord formation. Aim 2...
  32. Smooth muscle adhesion and plasticity in coronary and outflow tract development
    Joan M Taylor; Fiscal Year: 2013
    ..approaches to deplete leupaxin from SMC and these studies revealed that leupaxin was essential for SMC chemotaxis. We also made the interesting and potentially important discovery that leupaxin shuttles between focal adhesions ..
  33. Dissecting the Role of HIV-1 Tat &Chemokine Axis in Subtype-Specificity of HAD
    Vinayaka R Prasad; Fiscal Year: 2012
    ..We previously reported that subtype C HIV-1 Tat protein is defective in monocyte chemotaxis and proposed this as the basis for the reduction in HIV dementia in India...
  34. CAP37 and ocular inflammation
    HELOISE ANNE PEREIRA; Fiscal Year: 2011
    ..CAP37 is a potent antibiotic, promotes monocyte chemotaxis, and has immunomodulatory effects on host cells including corneal epithelial cells...
  35. MOLECULAR PATHOLOGY OF CHRONIC LUNG DISEASE
    Craig Gerard; Fiscal Year: 2013
    ..complex inhibits C5a mediated ERK1/2 activation, thereby negatively modulating C5a-C5aR chemotaxis. In order to further our goals of understanding the role of the complement anaphylatoxins in lung injury, and ..
  36. REDUCING LAPAROTOMY WOUND FAILURE
    Sufan Chien; Fiscal Year: 2013
    ..this technique operates via at least three pathways: 1) massive stem/progenitor cell trafficking and leukocyte chemotaxis caused by purinergic receptor activation;2) improved cell survival and function by intracellularly delivered ..
  37. Development of an Anti-PSGL-1 Antibody to Treat Crohn's Disease
    Scott A Rollins; Fiscal Year: 2011
    ..PSGL-1 also binds chemokines that amplify the inflammatory response through chemotaxis of inflammatory cells to endothelial cells that line the gut...
  38. Augmentation of Innate Anti-Microbial Immunity by TLR4 Agonists
    Edward R Sherwood; Fiscal Year: 2013
    ..by inducing G-CSF-mediated expansion of the bone marrow neutrophil pool and causing augmentation of neutrophil chemotaxis. Specific aim 2: To define intracellular signaling alterations by which MPLA augments resistance to infection...
  39. Genetic Basis of Virulence of Community MRSA Clone USA300
    Henry F Chambers; Fiscal Year: 2010
    ..PMN function will be assayed in vitro to determine whether virulence factors affect human PMN chemotaxis, phagocytosis, or bacterial killing...
  40. Microtubule dynamics during cell polarity and migration
    Torsten Wittmann; Fiscal Year: 2012
    ..of the cytoskeleton is essential for many cell behaviors, including directed migration during wound healing and chemotaxis. Microtubule polymerization dynamics are spatiotemporally regulated in planar polarized, migrating cells, and ..
  41. Role of Angiogenic CXC Chemokines in Intramembranous Bone Repair
    Dean T Yamaguchi; Fiscal Year: 2013
    ..be examined to see if CXCL5 and CXCL8, whose production is stimulated by canonical Wnt signaling, can stimulate chemotaxis and osteogenic differentiation of hMSC TERT cells that have been transduced with various CXCR2 constructs (wild ..
  42. Polarization and directed cell movements in engineered cellular environments
    Deborah E Leckband; Fiscal Year: 2010
    ..the proposed strategies in this R21 proposal will uniquely identify mechanisms governing cell adhesion and chemotaxis in cancer and in development...
  43. The Role of IgE in Autoimmune Skin Diseases
    Janet A Fairley; Fiscal Year: 2013
    ..These molecular interactions then trigger a pro-inflammatory response in the keratinocytes, eosinophil chemotaxis and degranulation of mast cells...
  44. Virulence Determinants of Borrelia burgdorferi
    Steven J Norris; Fiscal Year: 2013
    ..These analyses will include studies of genes involved in chemotaxis, motility, nutrient transport, surface proteins involved in adherence and other roles, novel gene regulation ..
  45. Personalized therapeutics for inhibiting breast cancer metastasis
    DEBRA AUGUSTE; Fiscal Year: 2012
    ..I will characterize the surface density and proximity of two G- protein coupled receptors that facilitate tumor chemotaxis, CXC chemokine receptor type 4 (CXCR4) and CC chemokine receptor type 7 (CCR7)...
  46. Cellular and Biochemical Studies of Myosin Assembly in Dictyostelium
    Thomas Egelhoff; Fiscal Year: 2009
    ..This simple amoeba displays forms of cellular motility, chemotaxis, and second messenger signaling similar to those displayed by motile mammalian cells such as neutrophils or ..
  47. Thrombospondin-1, VSMC Migration and Intimal Hyperplasia - a role for statins
    Vivian Gahtan; Fiscal Year: 2013
    ..will be tested by pursuing the following Specific Aims: 1) investigate how dyslipidemia modifies TSP-1-induced chemotaxis and signaling;2) elucidate the mechanisms of acute statin inhibition on TSP-1-induced signaling;3) determine the ..
  48. Reactive Oxygen Species Regulation of Vascular Smooth Muscle Cell Migration
    David S Weber; Fiscal Year: 2012
    ..we do not yet understand how ROS and/or upstream kinases regulate the cytoskeletal events that control cell chemotaxis, nor whether these novel mechanisms contribute to vascular pathology in vivo...
  49. Genetic Regulation of B Lymphocyte Aortic Homing and Atheroprotection
    Coleen A McNamara; Fiscal Year: 2013
    ..in reduced antagonism of human E12 activity allows repression of chemokine receptor expression, reducing chemotaxis and arterial homing of human B lymphocytes...
  50. Histone deacetylases and atherosclerosis
    Nilamadhab Mishra; Fiscal Year: 2010
    ..We will perform transendothelial migration, chemotaxis, and adhesion assays using macrophages expressing different amounts of HDAC9...
  51. Insulin-Like Growth Factor-1 and Atherosclerosis
    Patrice Delafontaine; Fiscal Year: 2013
    ..that monocyte/macrophage IGF-1 has anti-inflammatory and anti- atherogenic effects and suppresses monocyte chemotaxis, monocyte recruitment and adhesion to endothelium, macrophage lipid accumulation, macrophage oxidative stress/..
  52. Mechanisms of a Novel Chemotactic Cofactor for C5a
    Richard R Kew; Fiscal Year: 2011
    ..However, its role in vivo has not been determined and the mechanism of chemotaxis enhancement is not known...
  53. Characterization of CCR5-like Molecules in Leishmania
    Lynn Soong; Fiscal Year: 2010
    ..Our efforts will mostly be placed on conducting functional studies (Ca++ influx, chemotaxis and ligand binding/internalization assays) using murine and human CCR5 ligands, as well as ligands that do not ..
  54. Roles of Sphingolipids in the Pathophysiology of Obesity and Diabetes
    LAUREN ASHLEY COWART; Fiscal Year: 2013
    ..elevated muscle content of sphingosine-1-phosphate, a lipid mediator implicated in inflammation, migration, chemotaxis, and other key cell processes...
  55. Regulation of Migration of Autoreactive Germinal Centers and Precursor B Cells
    John D Mountz; Fiscal Year: 2013
    ..The ability of IL-17 and IFNa to regulate chemotaxis will be determined in vitro, and confirmed in vivo by analysis of homing of GFP-positive APChi B cells using B ..
  56. Extracellular Matrix Components, Oxidants and Antioxidants in Pulmonary Fibrosis
    CORRINE R KLIMENT; Fiscal Year: 2010
    ..studies will utilize in vitro heparin/HS fragmentation assays to study the protective role of EC-SOD and chemotaxis assays to analyze inflammatory responses to oxidatively fragmented heparin/HS and EC- SOD...
  57. Role of miRNA-375 in Invasive Phenotype of Head and Neck Squamous Cell Carcinoma
    Lizandra Jimenez; Fiscal Year: 2013
    ..transductant cell lines will be used to assess whether miR-375 expression levels affects growth, invasion, chemotaxis and matrix degradation in vitro, as well as, three-dimensional embedded growth, three-dimensional invasion with ..
  58. TNF-like weak inducer of apoptosis (TWEAK) signaling in lupus nephritis
    Chaim Putterman; Fiscal Year: 2013
    ..Injection of TWEAK to B6 mice increases MCP-1 expression, promotes chemotaxis of T cells and macrophages into the kidney, and stimulates glomerular cell proliferation;4...
  59. CpnA's role in cAMP signaling and the actin cytoskeleton in Dictyostelium
    Cynthia K Damer; Fiscal Year: 2013
    ..in Dictyostelium is widely used to study not only development, but also several basic cell processes including chemotaxis-mediated cell motility, signal transduction, programmed cell death, and cell differentiation...
  60. Cannabinoid modulation of microglial response to the HIV protein Tat
    Guy A Cabral; Fiscal Year: 2013
    ..The combined action of chemotaxis-driven aggregation of immunocytes at focal areas of infection and elicitation of inflammatory factors may be a ..
  61. Biologic Activities of the pertusis toxin B-pentamer
    ALISON A contact WEISS; Fiscal Year: 2010
    ..Specific Aim 2. Determine the mechanism by which PTX-B attenuates chemokine receptor signaling and chemotaxis. The mechanism by which PTX-B affects chemokine receptor activity remains largely unknown...
  62. Delineation of Borrelia burgdorferi motility and chemotaxis in the development of
    MD A MOTALEB; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Delineation of Borrelia burgdorferi motility and chemotaxis in the development of Lyme disease Lyme disease is caused by the spirochetal bacteria Borrelia burgdorferi (Bb), which is transmitted to ..
  63. Blood Brain Barrier Physiology and HIV Dementia
    HOWARD GENDELMAN; Fiscal Year: 2007
    ..If macrophage chemotaxis and/or its transendothelial migration could be halted disease could be abrogated...
  64. The role of Borrelia burgdorferi chemotoxis in the pathogenesis of Lyme disease
    Md Motaleb; Fiscal Year: 2009
    ..However, the mechanisms involved in this invasive process are largely unknown. While motility and chemotaxis are critical for many pathogenic organisms to colonize and/or cause disease, the role of these processes in B...
  65. Multi-Dimensional Separation of Bacteria
    G Scott Worthen; Fiscal Year: 2010
    ..microfluidic sorter based on both structural (size-and shape and Electrophoresis) and functional (Adhesion, Chemotaxis) parameters to separate a complex bacterial mixture into bins containing bacteria that share common properties...
  66. PERIODONTAL LIGAMENT CELL AUTOCRINE FACTOR
    VICTOR TERRANOVA; Fiscal Year: 1993
    ..Essential biological events involved in wound healing are chemotaxis of a multitude of different cell types and subsequent proliferation and survival of a limited number of specific ..
  67. Role of CIC-3 channels in regulation of cell volume and shape in neutrophils
    Jessica Moreland; Fiscal Year: 2007
    ..b>Chemotaxis, phagocytosis, and bactericidal activity are functions integral to the contribution of polymorphonuclear ..
  68. Chemoreception and Signal Amplification
    MICHAEL MANSON; Fiscal Year: 2005
    Bacterial chemotaxis is a virulence factor for pathogenic bacteria and is a model for recognition of, and response to chemicals in unicellular and multicellular organisms...