cell proliferation

Summary

Summary: All of the processes involved in increasing in CELL NUMBER. These processes include more than CELL DIVISION which is part of the CELL CYCLE.

Top Publications

  1. pmc Understanding the Warburg effect: the metabolic requirements of cell proliferation
    Matthew G Vander Heiden
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Science 324:1029-33. 2009
  2. ncbi A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    Catherine A O'Brien
    Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, M5G 1L7, Canada
    Nature 445:106-10. 2007
  3. pmc Development of monocytes, macrophages, and dendritic cells
    Frederic Geissmann
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
    Science 327:656-61. 2010
  4. pmc Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
    Rajnish A Gupta
    Howard Hughes Medical Institute and Program in Epithelial Biology, California 94305, USA
    Nature 464:1071-6. 2010
  5. pmc AKT/PKB signaling: navigating downstream
    Brendan D Manning
    Department of Genetics and Complex Diseases, Harvard School of Public Health, SPH2 117, Boston, MA 02115, USA
    Cell 129:1261-74. 2007
  6. ncbi Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    Patrick C Hermann
    Department of Surgery, Ludwig Maximilians University, 81377 Munich, Germany
    Cell Stem Cell 1:313-23. 2007
  7. pmc miR-15 and miR-16 induce apoptosis by targeting BCL2
    Amelia Cimmino
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus OH 43210, USA
    Proc Natl Acad Sci U S A 102:13944-9. 2005
  8. ncbi Induced pluripotent stem cell lines derived from human somatic cells
    Junying Yu
    Genome Center of Wisconsin, Madison, WI 53706 1580, USA
    Science 318:1917-20. 2007
  9. ncbi Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    Manabu Soda
    Division of Functional Genomics, Jichi Medical University, Tochigi 329 0498, Japan
    Nature 448:561-6. 2007
  10. pmc The ground state of embryonic stem cell self-renewal
    Qi Long Ying
    Center for Stem Cell and Regenerative Medicine, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, ZNI 529, Los Angeles, California 90033, USA
    Nature 453:519-23. 2008

Research Grants

  1. Effects of herbs on transcription and cell proliferation
    Dale Leitman; Fiscal Year: 2003
  2. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
  3. Yun Fai Chris Lau; Fiscal Year: 2014
  4. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
  5. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
  6. Bandana Chatterjee; Fiscal Year: 2016
  7. ENEIQUE A MESRI; Fiscal Year: 2016
  8. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
  9. The role of Fli1 in T cell function and the pathogenesis of lupus
    Tamara K Nowling; Fiscal Year: 2011
  10. Bayar Thimmapaya; Fiscal Year: 2016

Detail Information

Publications435 found, 100 shown here

  1. pmc Understanding the Warburg effect: the metabolic requirements of cell proliferation
    Matthew G Vander Heiden
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Science 324:1029-33. 2009
    ..Supporting this idea are recent studies showing that (i) several signaling pathways implicated in cell proliferation also regulate metabolic pathways that incorporate nutrients into biomass; and that (ii) certain cancer-..
  2. ncbi A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    Catherine A O'Brien
    Division of Cell and Molecular Biology, University Health Network, Toronto, Ontario, M5G 1L7, Canada
    Nature 445:106-10. 2007
    ....
  3. pmc Development of monocytes, macrophages, and dendritic cells
    Frederic Geissmann
    Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King s College London, Great Maze Pond, London SE1 1UL, UK
    Science 327:656-61. 2010
    ..Despite this, the origin and differentiation cues for many tissue macrophages, monocytes, and dendritic cell subsets in mice, and the corresponding cell populations in humans, remain to be elucidated...
  4. pmc Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
    Rajnish A Gupta
    Howard Hughes Medical Institute and Program in Epithelial Biology, California 94305, USA
    Nature 464:1071-6. 2010
    ..These findings indicate that lincRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy...
  5. pmc AKT/PKB signaling: navigating downstream
    Brendan D Manning
    Department of Genetics and Complex Diseases, Harvard School of Public Health, SPH2 117, Boston, MA 02115, USA
    Cell 129:1261-74. 2007
    ..In addition, we discuss those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration...
  6. ncbi Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    Patrick C Hermann
    Department of Surgery, Ludwig Maximilians University, 81377 Munich, Germany
    Cell Stem Cell 1:313-23. 2007
    ..Strategies aimed at modulating the SDF-1/CXCR4 axis may have important clinical applications to inhibit metastasis of cancer stem cells...
  7. pmc miR-15 and miR-16 induce apoptosis by targeting BCL2
    Amelia Cimmino
    Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus OH 43210, USA
    Proc Natl Acad Sci U S A 102:13944-9. 2005
    ..BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors...
  8. ncbi Induced pluripotent stem cell lines derived from human somatic cells
    Junying Yu
    Genome Center of Wisconsin, Madison, WI 53706 1580, USA
    Science 318:1917-20. 2007
    ....
  9. ncbi Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
    Manabu Soda
    Division of Functional Genomics, Jichi Medical University, Tochigi 329 0498, Japan
    Nature 448:561-6. 2007
    ..Our data demonstrate that a subset of NSCLC patients may express a transforming fusion kinase that is a promising candidate for a therapeutic target as well as for a diagnostic molecular marker in NSCLC...
  10. pmc The ground state of embryonic stem cell self-renewal
    Qi Long Ying
    Center for Stem Cell and Regenerative Medicine, Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, 1501 San Pablo Street, ZNI 529, Los Angeles, California 90033, USA
    Nature 453:519-23. 2008
    ..This property may account for their latent tumorigenicity. The delineation of minimal requirements for self-renewal now provides a defined platform for the precise description and dissection of the pluripotent state...
  11. pmc Endogenous human microRNAs that suppress breast cancer metastasis
    Sohail F Tavazoie
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nature 451:147-52. 2008
    ..miR-335 and miR-126 are thus identified as metastasis suppressor microRNAs in human breast cancer...
  12. ncbi Bone morphogenetic proteins
    Di Chen
    School of Medicine and Dentistry, Department of Orthopaedics, University of Rochester, Rochester, NY 14642, USA
    Growth Factors 22:233-41. 2004
    ..A significant advancement about the understanding of in vivo functions of BMP ligands, receptors and signaling molecules has been achieved in recent years...
  13. ncbi let-7 regulates self renewal and tumorigenicity of breast cancer cells
    Fengyan Yu
    Department of Breast Surgery, No 2 Affiliated Hospital, Sun Yat Sen University, Guangzhou 510120, People s Republic of China
    Cell 131:1109-23. 2007
    ..Therefore let-7 regulates multiple BT-IC stem cell-like properties by silencing more than one target...
  14. ncbi Molecular requirements for epithelial-mesenchymal transition during tumor progression
    Margit A Huber
    Department of Dermatology, Vienna Medical University, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Curr Opin Cell Biol 17:548-58. 2005
    ..Increasing evidence suggests that EMT plays a specific role in the migration of cells from a primary tumor into the circulation and may provide a rationale for developing more effective cancer therapies...
  15. doi An oncogene-induced DNA damage model for cancer development
    Thanos D Halazonetis
    Department of Molecular Biology and Department of Biochemistry, University of Geneva, CH 1205 Geneva, Switzerland
    Science 319:1352-5. 2008
    ..One might have, therefore, anticipated that a sizable number of DNA DSBs would be incompatible with cell proliferation. Yet recent experimental findings suggest that, in both precancerous lesions and cancers, activated ..
  16. pmc Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
    Kenneth P Olive
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 ORE, UK
    Science 324:1457-61. 2009
    ..Thus, inefficient drug delivery may be an important contributor to chemoresistance in pancreatic cancer...
  17. pmc Four faces of cellular senescence
    Francis Rodier
    The Research Centre of the University of Montreal Hospital Centre Institut du Cancer de Montréal, Montreal, Quebec, Canada
    J Cell Biol 192:547-56. 2011
    ..The challenge now is to understand the senescence response well enough to harness its benefits while suppressing its drawbacks...
  18. pmc An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
    Carson C Thoreen
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    J Biol Chem 284:8023-32. 2009
    ..Our findings challenge the assumption that rapamycin completely inhibits mTORC1 and indicate that direct inhibitors of mTORC1 kinase activity may be more successful than rapamycin at inhibiting tumors that depend on mTORC1...
  19. doi Cell cycle, CDKs and cancer: a changing paradigm
    Marcos Malumbres
    Cell Division and Cancer Group, Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas CNIO, 28029 Madrid, Spain
    Nat Rev Cancer 9:153-66. 2009
    ..Emerging evidence suggests that tumour cells may also require specific interphase CDKs for proliferation. Thus, selective CDK inhibition may provide therapeutic benefit against certain human neoplasias...
  20. ncbi Generation of germline-competent induced pluripotent stem cells
    Keisuke Okita
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Nature 448:313-7. 2007
    ..Thus, iPS cells competent for germline chimaeras can be obtained from fibroblasts, but retroviral introduction of c-Myc should be avoided for clinical application...
  21. doi Tumor cell metabolism: cancer's Achilles' heel
    Guido Kroemer
    INSERM, U848, F 94805 Villejuif, France
    Cancer Cell 13:472-82. 2008
    ..Specifically, we discuss the alterations in signal transduction pathways and/or enzymatic machineries that account for metabolic reprogramming of transformed cells...
  22. pmc miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements
    Ashish Lal
    Immune Disease Institute, Children s Hospital Boston, Department of Pediatrics, Harvard Medical School, MA 02115, USA
    Mol Cell 35:610-25. 2009
    ..Antagonizing miR-24 restores postmitotic cell proliferation and enhances fibroblast proliferation, whereas overexpressing miR-24 increases the G1 compartment...
  23. ncbi Restoring function in exhausted CD8 T cells during chronic viral infection
    Daniel L Barber
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nature 439:682-7. 2006
    ..These studies identify a specific mechanism of T-cell exhaustion and define a potentially effective immunological strategy for the treatment of chronic viral infections...
  24. doi Fibroblast growth factor signalling: from development to cancer
    Nicholas Turner
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London SW3 6JB, UK, and Royal Marsden Hospital, London SW3 6JJ, UK
    Nat Rev Cancer 10:116-29. 2010
    ....
  25. ncbi Human mesenchymal stem cells modulate B-cell functions
    Anna Corcione
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Blood 107:367-72. 2006
    ..B-cell proliferation was inhibited by hMSCs through an arrest in the G0/G1 phase of the cell cycle and not through the induction ..
  26. ncbi Adipose-derived stem cells for regenerative medicine
    Jeffrey M Gimble
    Stem Cell Biology Laboratory and Clinical Nutrition Research Unit, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Circ Res 100:1249-60. 2007
    ..The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in this article...
  27. doi The interleukin-8 pathway in cancer
    David J J Waugh
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland
    Clin Cancer Res 14:6735-41. 2008
    ..Therefore, inhibiting the effects of IL-8 signaling may be a significant therapeutic intervention in targeting the tumor microenvironment...
  28. pmc Evidence for cardiomyocyte renewal in humans
    Olaf Bergmann
    Department of Cell and Molecular Biology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Science 324:98-102. 2009
    ..The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies...
  29. doi Blinded by the Light: The Growing Complexity of p53
    Karen H Vousden
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Cell 137:413-31. 2009
    ..Control of p53's transcriptional activity is crucial for determining which p53 response is activated, a decision we must understand if we are to exploit efficiently the next generation of drugs that selectively activate or inhibit p53...
  30. pmc Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance
    James A McCubrey
    Department of Microbiology and Immunology, Leo Jenkins Cancer Center, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA
    Biochim Biophys Acta 1773:1263-84. 2007
    ....
  31. ncbi miR-21-mediated tumor growth
    M L Si
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Oncogene 26:2799-803. 2007
    ..this anti-miR-21-mediated cell growth inhibition was associated with increased apoptosis and decreased cell proliferation, which could be in part owing to downregulation of the antiapoptotic Bcl-2 in anti-miR-21-treated tumor ..
  32. doi The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
    Ralph J DeBerardinis
    Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Cell Metab 7:11-20. 2008
    b>Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all macromolecular components during each passage through the cell cycle...
  33. pmc Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis
    Angie M Cheng
    Ambion, Inc 2130 Woodward Street, Austin, TX 78744 1832, USA
    Nucleic Acids Res 33:1290-7. 2005
    ..From these screens, we conclude that miRNA-mediated regulation has a complexity of cellular outcomes and that miRNAs can be mediators of regulation of cell growth and apoptosis pathways...
  34. ncbi A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
    Chloe James
    INSERM U362, Institut Gustave Roussy, Paris XI University, PR1, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Nature 434:1144-8. 2005
    ..As this mutation is also found in other myeloproliferative disorders, this unique mutation will permit a new molecular classification of these disorders and novel therapeutical approaches...
  35. doi Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
    Evert Kroon
    Novocell, Inc, 3550 General Atomics Ct, San Diego, California 92121, USA
    Nat Biotechnol 26:443-52. 2008
    ..Together, these data provide definitive evidence that hES cells are competent to generate glucose-responsive, insulin-secreting cells...
  36. pmc Activation of a metabolic gene regulatory network downstream of mTOR complex 1
    Katrin Düvel
    Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    Mol Cell 39:171-83. 2010
    ..Therefore, in addition to promoting protein synthesis, mTORC1 activates specific bioenergetic and anabolic cellular processes that are likely to contribute to human physiology and disease...
  37. doi RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
    Georgia Hatzivassiliou
    Genentech, South San Francisco, California 94080, USA
    Nature 464:431-5. 2010
    ..Furthermore, this work provides new insights into the therapeutic use of ATP-competitive RAF inhibitors...
  38. ncbi Mesenchymal stem cells reside in virtually all post-natal organs and tissues
    Lindolfo da Silva Meirelles
    Departamento de Genetica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    J Cell Sci 119:2204-13. 2006
    ..These findings have implications for understanding MSC biology, and for clinical and pharmacological purposes...
  39. doi Stem cells, self-renewal, and differentiation in the intestinal epithelium
    Laurens G van der Flier
    Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, 3584 CT, Utrecht, The Netherlands
    Annu Rev Physiol 71:241-60. 2009
    ..This high cell turnover makes it a very attractive and comprehensive adult organ system for the study of cell proliferation and differentiation...
  40. pmc miR-145 and miR-143 regulate smooth muscle cell fate and plasticity
    Kimberly R Cordes
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94158, USA
    Nature 460:705-10. 2009
    ..These findings demonstrate that miR-145 can direct the smooth muscle fate and that miR-145 and miR-143 function to regulate the quiescent versus proliferative phenotype of smooth muscle cells...
  41. doi The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    Heather R Christofk
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 452:230-3. 2008
    ..These results demonstrate that M2 expression is necessary for aerobic glycolysis and that this metabolic phenotype provides a selective growth advantage for tumour cells in vivo...
  42. pmc VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    Rosandra N Kaplan
    Department of Pediatrics and the Children s Blood Foundation Laboratories, Weill Cornell Medical College of Cornell University, New York, New York 10021, USA
    Nature 438:820-7. 2005
    ..These findings demonstrate a requirement for VEGFR1+ haematopoietic progenitors in the regulation of metastasis, and suggest that expression patterns of fibronectin and VEGFR1+VLA-4+ clusters dictate organ-specific tumour spread...
  43. ncbi Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
    S G M Piccirillo
    Department of Biotechnology and Biosciences, University of Milan Bicocca, 20126 Milan, Italy
    Nature 444:761-5. 2006
    ....
  44. pmc p53 represses c-Myc through induction of the tumor suppressor miR-145
    Mohit Sachdeva
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA
    Proc Natl Acad Sci U S A 106:3207-12. 2009
    ....
  45. doi p53 and metabolism
    Karen H Vousden
    The Beatson Institute for Cancer Research, Garscube Estate, Glasgow G61 1BD, UK
    Nat Rev Cancer 9:691-700. 2009
    ....
  46. pmc Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized
    Elsa Quintana
    Howard Hughes Medical Institute
    Cancer Cell 18:510-23. 2010
    ..Some melanomas metastasized in mice, irrespective of whether they arose from CD271(-) or CD271(+) cells. Many markers appeared to be reversibly expressed by tumorigenic melanoma cells...
  47. doi Hedgehog signaling in development and cancer
    Jin Jiang
    Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Dev Cell 15:801-12. 2008
    ..We discuss how the Hh pathway has diverged during evolution and how it integrates with other signaling pathways to control cell growth and patterning...
  48. pmc Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    Ralph J DeBerardinis
    Department of Cancer Biology, Abramson Cancer Center, University of Pennsylvania, Room 450, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
    Proc Natl Acad Sci U S A 104:19345-50. 2007
    Tumor cell proliferation requires rapid synthesis of macromolecules including lipids, proteins, and nucleotides...
  49. ncbi Rejuvenation of aged progenitor cells by exposure to a young systemic environment
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 433:760-4. 2005
    ..The decline in hepatic progenitor cell proliferation owing to the formation of a complex involving cEBP-alpha and the chromatin remodelling factor brahma (Brm) ..
  50. doi microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma
    Benjamin Kefas
    Division of Neuro Oncology, Neurology Department, University of Virginia Health System, Charlottesville, Virginia, USA
    Cancer Res 68:3566-72. 2008
    ..This study establishes miR-7 as a regulator of major cancer pathways and suggests that it has therapeutic potential for glioblastoma...
  51. pmc Development of a second-generation antiandrogen for treatment of advanced prostate cancer
    Chris Tran
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Science 324:787-90. 2009
    ..These compounds thus appear to be promising candidates for treatment of advanced prostate cancer...
  52. pmc ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    Christophe Ginestier
    Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Stem Cell 1:555-67. 2007
    ..These findings offer an important new tool for the study of normal and malignant breast stem cells and facilitate the clinical application of stem cell concepts...
  53. pmc c-Myc regulates transcriptional pause release
    Peter B Rahl
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 141:432-45. 2010
    ..We discuss the implications of these results for the role of c-Myc amplification in human cancer...
  54. pmc The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    Meghan A Koch
    Benaroya Research Institute, Seattle, Washington, USA
    Nat Immunol 10:595-602. 2009
    ....
  55. pmc RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
    Johannes Zuber
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 478:524-8. 2011
    ....
  56. ncbi Adult neurogenesis in the mammalian central nervous system
    Guo li Ming
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Annu Rev Neurosci 28:223-50. 2005
    ..Advances in our understanding of adult neurogenesis will not only shed light on the basic principles of adult plasticity, but also may lead to strategies for cell replacement therapy after injury or degenerative neurological diseases...
  57. ncbi Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis
    Christos Sotiriou
    Functional Genomics and Translational Research Unit, Universite Libre de Bruxelles, Brussels, Belgium
    J Natl Cancer Inst 98:262-72. 2006
    ..We examined whether histologic grade was associated with gene expression profiles of breast cancers and whether such profiles could be used to improve histologic grading...
  58. ncbi Transforming growth factor-beta regulation of immune responses
    Ming O Li
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Immunol 24:99-146. 2006
    ..This review highlights the findings that have advanced our understanding of TGF-beta in the immune system and in disease...
  59. pmc Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
    Linda S Steelman
    Department of Microbiology and Immunology, East Carolina University, Greenville, NC 27858, USA
    Aging (Albany NY) 3:192-222. 2011
    ..Finally the recently described roles of these pathways in cancer stem cells, cellular senescence and aging will be evaluated. Controlling the expression of these pathways could ameliorate human health...
  60. ncbi MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    Jeffrey A Engelman
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Science 316:1039-43. 2007
    ..Thus, we propose that MET amplification may promote drug resistance in other ERBB-driven cancers as well...
  61. pmc Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    Cheng Ming Sun
    Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:1775-85. 2007
    ..Together, these data demonstrate that the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion...
  62. pmc Meta-analysis of gene expression profiles in breast cancer: toward a unified understanding of breast cancer subtyping and prognosis signatures
    Pratyaksha Wirapati
    Swiss Institute of Bioinformatics, Batiment Genopode, University of Lausanne, 1015 Lausanne, Switzerland
    Breast Cancer Res 10:R65. 2008
    ....
  63. pmc miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
    Li Ma
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Cell Biol 12:247-56. 2010
    ..These findings uncover a regulatory and signalling pathway involving a metastasis-promoting miRNA that is predicted to directly target expression of the key metastasis-suppressing protein E-cadherin...
  64. doi E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer
    Fabio Petrocca
    Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Ohio State University, 460 West 12th Avenue, Columbus, OH 43210, USA
    Cancer Cell 13:272-86. 2008
    ..Together, these results suggest that the miR-106b-25 cluster is involved in E2F1 posttranscriptional regulation and may play a key role in the development of TGFbeta resistance in gastric cancer...
  65. pmc Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    Zhizhong Li
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Cell 15:501-13. 2009
    ..Our results demonstrate that GSCs differentially respond to hypoxia with distinct HIF induction patterns, and HIF2alpha might represent a promising target for antiglioblastoma therapies...
  66. doi Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal
    Jakub Godlewski
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center and James Comprehensive Cancer Center, Columbus, Ohio 43210
    Cancer Res 68:9125-30. 2008
    ..miR-128 expression significantly reduced glioma cell proliferation in vitro and glioma xenograft growth in vivo...
  67. pmc Tumor suppressors and cell metabolism: a recipe for cancer growth
    Russell G Jones
    Rosalind and Morris Goodman Cancer Centre, McGill University, Montreal, Quebec, H3A 1A3, Canada
    Genes Dev 23:537-48. 2009
    ..face two major metabolic challenges-how to meet the bioenergetic and biosynthetic demands of increased cell proliferation, and how to survive environmental fluctuations in external nutrient and oxygen availability when tumor ..
  68. pmc Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells
    Genevieve L Weber
    Ludwig Collaborative Laboratory, Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Oncotarget 2:833-49. 2011
    ..We conclude that PIK3R1, like PIK3CA, is a potential therapeutic target in GBM and that it also influences tumor cell growth and motility...
  69. ncbi Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
    Raffaella Di Micco
    IFOM Foundation FIRC Institute of Molecular Oncology Foundation, 20139 Milan, Italy
    Nature 444:638-42. 2006
    Early tumorigenesis is associated with the engagement of the DNA-damage checkpoint response (DDR). Cell proliferation and transformation induced by oncogene activation are restrained by cellular senescence...
  70. ncbi Clonogenic assay of cells in vitro
    Nicolaas A P Franken
    Laboratory for Experimental Oncology and Radiobiology, Department of Radiotherapy, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Nat Protoc 1:2315-9. 2006
    ..Colonies are fixed with glutaraldehyde (6.0% v/v), stained with crystal violet (0.5% w/v) and counted using a stereomicroscope. A method for the analysis of radiation dose-survival curves is included...
  71. doi Accessories to the crime: functions of cells recruited to the tumor microenvironment
    Douglas Hanahan
    The Swiss Institute for Experimental Cancer Research, School of Life Sciences, Swiss Federal Institute of Technology Lausanne, CH 1015 Lausanne, Switzerland
    Cancer Cell 21:309-22. 2012
    ..This enhanced understanding presents interesting new targets for anticancer therapy...
  72. doi Crypt stem cells as the cells-of-origin of intestinal cancer
    Nick Barker
    Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584CT Utrecht and University Medical Centre Utrecht, Netherlands
    Nature 457:608-11. 2009
    ..Even after 30weeks, large adenomas are very rare in these mice. We conclude that stem-cell-specific loss of Apc results in progressively growing neoplasia...
  73. pmc Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture
    Louise C Laurent
    Department of Reproductive Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Stem Cell 8:106-18. 2011
    ..Our results illustrate the dynamic nature of genomic abnormalities in pluripotent stem cells and the need for frequent genomic monitoring to assure phenotypic stability and clinical safety...
  74. doi Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
    Sophia Y Lunt
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Cell Dev Biol 27:441-64. 2011
    ....
  75. pmc The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
    Jian Fu Chen
    Carolina Cardiovascular Biology Center, Department of Cell and Developmental Biology, University of North Carolina Chapel Hill, North Carolina 27599, USA
    Nat Genet 38:228-33. 2006
    ..Together, our studies suggest a molecular mechanism in which miRNAs participate in transcriptional circuits that control skeletal muscle gene expression and embryonic development...
  76. pmc Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    Johan Skog
    Department of Neurology, Massachusetts General Hospital, and Neuroscience Program, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Nat Cell Biol 10:1470-6. 2008
    ..Thus, tumour-derived microvesicles may provide diagnostic information and aid in therapeutic decisions for cancer patients through a blood test...
  77. doi Signal integration by JNK and p38 MAPK pathways in cancer development
    Erwin F Wagner
    Centro Nacional de Investigaciones Oncologicas, C Melchor Fernandez Almagro 3, Madrid 28029, Spain
    Nat Rev Cancer 9:537-49. 2009
    ..In this Review we highlight the recent progress made in defining the functions of the JNK and p38 MAPK pathways in different cancers...
  78. pmc Elucidation of a universal size-control mechanism in Drosophila and mammals
    Jixin Dong
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 130:1120-33. 2007
    Coordination of cell proliferation and cell death is essential to attain proper organ size during development and for maintaining tissue homeostasis throughout postnatal life...
  79. doi Regulation of progenitor cell proliferation and granulocyte function by microRNA-223
    Jonathan B Johnnidis
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Nature 451:1125-9. 2008
    ..Our data support a model in which miR-223 acts as a fine-tuner of granulocyte production and the inflammatory response...
  80. pmc Links between metabolism and cancer
    Chi V Dang
    Abramson Cancer Center, Abramson Family Cancer Research Institute, Division of Hematology Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 26:877-90. 2012
    ....
  81. pmc Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
    Mohit Jain
    Broad Institute, Cambridge, MA 02142, USA
    Science 336:1040-4. 2012
    ..Moreover, higher expression of this pathway was associated with greater mortality in breast cancer patients. Increased reliance on glycine may represent a metabolic vulnerability for selectively targeting rapid cancer cell proliferation.
  82. doi Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Nat Neurosci 11:1153-61. 2008
    ....
  83. ncbi TOR signaling in growth and metabolism
    Stephan Wullschleger
    Biozentrum, University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Cell 124:471-84. 2006
    ..The physiological consequences of mammalian TORC1 dysregulation suggest that inhibitors of mammalian TOR may be useful in the treatment of cancer, cardiovascular disease, autoimmunity, and metabolic disorders...
  84. ncbi Identification and expansion of human colon-cancer-initiating cells
    Lucia Ricci-Vitiani
    Department of Hematology and Oncology, Istituto Superiore di Sanita, Viale Regina Elena 299, Rome 00161, Italy
    Nature 445:111-5. 2007
    ..We conclude that colorectal cancer is created and propagated by a small number of undifferentiated tumorigenic CD133+ cells, which should therefore be the target of future therapies...
  85. pmc STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer
    Dimitrios Iliopoulos
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 39:493-506. 2010
    ..Thus, STAT3 is not only a downstream target of IL-6 but, with miR-21, miR-181b-1, PTEN, and CYLD, is part of the positive feedback loop that underlies the epigenetic switch that links inflammation to cancer...
  86. ncbi Why do cancers have high aerobic glycolysis?
    Robert A Gatenby
    Department of Radiology, University of Arizona, Tucson, Arizona 85721, USA
    Nat Rev Cancer 4:891-9. 2004
    ..Subsequent cell populations with upregulated glycolysis and acid resistance have a powerful growth advantage, which promotes unconstrained proliferation and invasion...
  87. doi Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation
    Zhe Yang
    Ministry of Public Health, Key Laboratory of Organ Transplantation, Zhejiang Province, Zhejiang, China
    Ann Surg Oncol 18:1243-50. 2011
    ..The aim of the present study is to examine the expression pattern of HOTAIR in hepatocellular carcinoma (HCC) and its clinical significance as well as its biological role in tumor progression...
  88. pmc Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation
    Stephen J Jenkins
    Centre for Immunity, Infection and Evolution, and the Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Science 332:1284-8. 2011
    ..Thus, expansion of innate cells necessary for pathogen control or wound repair can occur without recruitment of potentially tissue-destructive inflammatory cells...
  89. ncbi The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP
    Jianbin Huang
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA
    Cell 122:421-34. 2005
    Coordination between cell proliferation and cell death is essential to maintain homeostasis in multicellular organisms...
  90. ncbi Switching from repression to activation: microRNAs can up-regulate translation
    Shobha Vasudevan
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 318:1931-4. 2007
    ..Thus, activation is a common function of microRNPs on cell cycle arrest. We propose that translation regulation by microRNPs oscillates between repression and activation during the cell cycle...
  91. pmc Kaposi's sarcoma and its associated herpesvirus
    Enrique A Mesri
    Viral Oncology Program, Developmental Center for AIDS Research, and Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1, 550 NW 10th Avenue, 109 Papanicolau Building, Miami, Florida 33136, USA
    Nat Rev Cancer 10:707-19. 2010
    ..as latency-associated nuclear antigen (LANA), viral cyclin, viral FLIP and viral-encoded microRNAs, drive cell proliferation and prevent apoptosis, whereas KSHV lytic proteins, such as viral G protein-coupled receptor, K1 and virally ..
  92. pmc Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
    Richard Possemato
    Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 476:346-50. 2011
    ..of PHGDH in cell lines with elevated PHGDH expression, but not in those without, causes a strong decrease in cell proliferation and a reduction in serine synthesis...
  93. ncbi Cancer as an evolutionary and ecological process
    Lauren M F Merlo
    Cellular and Molecular Oncology Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nat Rev Cancer 6:924-35. 2006
    ..The tools of evolutionary biology and ecology are providing new insights into neoplastic progression and the clinical control of cancer...
  94. pmc A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth
    Qianben Wang
    Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 27:380-92. 2007
    ..These collaborating factors, together with AR, form a regulatory hierarchy that governs androgen-dependent gene expression and prostate cancer growth and offer potential new opportunities for therapeutic intervention...
  95. pmc MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    Fanyin Meng
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas, USA
    Gastroenterology 133:647-58. 2007
    ..Although a role for aberrant miRNA expression in cancer has been postulated, the pathophysiologic role and relevance of aberrantly expressed miRNA to tumor biology has not been established...
  96. pmc Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    Bin Zhao
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 21:2747-61. 2007
    The Hippo pathway plays a key role in organ size control by regulating cell proliferation and apoptosis in Drosophila...
  97. pmc Mesenchymal stem cells: revisiting history, concepts, and assays
    Paolo Bianco
    Cell Stem Cell 2:313-9. 2008
    ..This commentary revisits the experimental origin of the concept of the population(s) referred to as mesenchymal stem cells and the experimental framework required to assess their stemness and function...
  98. doi Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
    Sauveur Michel Maira
    Oncology Disease Area, Novartis Institutes for BioMedical Research, Novartis Pharma AG, CH4002 Basel, Switzerland
    Mol Cancer Ther 7:1851-63. 2008
    ..Collectively, the preclinical data show that NVP-BEZ235 is a potent dual PI3K/mTOR modulator with favorable pharmaceutical properties. NVP-BEZ235 is currently in phase I clinical trials...
  99. doi Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
    Toshiro Sato
    Hubrecht Institute, KNAW and University Medical Centre Utrecht, Utrecht, The Netherlands
    Gastroenterology 141:1762-72. 2011
    ..We have adapted the culture conditions to grow similar epithelial organoids from mouse colon and human small intestine and colon...
  100. pmc A human memory T cell subset with stem cell-like properties
    Luca Gattinoni
    Center for Cancer Research, National Cancer Institute, US National Institutes of Health NIH, Bethesda, Maryland, USA
    Nat Med 17:1290-7. 2011
    ..The identification of a human stem cell-like memory T cell population is of direct relevance to the design of vaccines and T cell therapies...
  101. ncbi AP-1 subunits: quarrel and harmony among siblings
    Jochen Hess
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, 69120 Heidelberg, Germany
    J Cell Sci 117:5965-73. 2004
    ....

Research Grants74

  1. Effects of herbs on transcription and cell proliferation
    Dale Leitman; Fiscal Year: 2003
    ..Our studies with MCF-7 cells indicate that ER-alpha mediates cell proliferation in response to estrogens. The role of ER-beta is breast cancer is unknown...
  2. Xenoestrogen regulation of Leydig cells
    BENSON TOKUNBO AKINGBEMI; Fiscal Year: 2010
    ..affect mesenchymal Leydig cell precursors in the prenatal and/or neonatal period, which alters Leydig cell proliferation and population (Aim I);Estrogen regulation of Leydig cell mitosis is mediated by interaction of signaling ..
  3. Yun Fai Chris Lau; Fiscal Year: 2014
    ..TSPY potentiates cell proliferation, accelerates the transition and disrupts the G2/M checkpoints, binds cyclin B and enhances cyclin B-CDK1 ..
  4. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..and characterize cell signaling by OPN-R in comparison to OPN-FL and OPN-L in terms of cell adhesion, cell proliferation, apoptosis, protein phosphorylation, gene expression and cytokine production...
  5. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    ..ameliorates approximately 40-50% of the increase in QO2/TNa), 3) increased kidney gluconeogenesis, 4) kidney cell proliferation due to growth stimuli using DFMO, inhibitor of ornithine decarboxylase, 5) NADPH oxidase and ROS, 6) ..
  6. Bandana Chatterjee; Fiscal Year: 2016
    ..to a prohibitin- and Alien-included corepressor assembly, which mediates E2F1 gene repression and reduced cell proliferation;b) E2F1 repression is aided by self inhibition at an auto-regulated site in the E2F1 promoter that results ..
  7. ENEIQUE A MESRI; Fiscal Year: 2016
    ..RacCA tumorigenesis was linked to male gender, and involved ROS activation of angiogenesis and cell proliferation. Furthermore, we found that AIDS-KS lesions and KSHV-infected tumors from our KS mouse model (mouse ..
  8. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ..Biomarkers that respond to CR and certain mADF regimens include global cell proliferation (mammary, prostate, skin, liver, lymphocytes), adipose tissue dynamics and fat distribution, insulin ..
  9. The role of Fli1 in T cell function and the pathogenesis of lupus
    Tamara K Nowling; Fiscal Year: 2011
    ..We propose to study cell proliferation, apoptosis and suppressor and effector functions of T cells in mice expressing reduced Fli1 activity and to ..
  10. Bayar Thimmapaya; Fiscal Year: 2016
    ..It is unclear, however, as to how cell proliferation and metabolism are interconnected and coregulated in liver...
  11. Role of Polyamines in MYCN-Amplified Neuroblastoma
    ANDRE BACHMANN; Fiscal Year: 2009
    ..metabolism, and whether this translates into changes in polyamine pools, cell cycle progression, and cell proliferation. These studies will be performed using three unique NB cell lines, in which MYCN expression can be switched ..
  12. GENETIC ANALYSIS OF POLARITY
    RUTH M STEWARD; Fiscal Year: 2010
    ..We have identified a new gene, zfrp8, controlling cell proliferation of the hematopoietic organs, the lymph glands...
  13. Retinoid Metabolism and Alcohol Induced Disease
    William S Blaner; Fiscal Year: 2010
    ..vitamin A and its metabolites) are potent transcriptional regulators that are needed for mediating normal cell proliferation, differentiation and apoptosis...
  14. DNA methylation of extracellular superoxide dismutase in pulmonary hypertension
    EVA NOZIK GRAYCK; Fiscal Year: 2012
    ..of the EC-SOD promoter inhibits EC-SOD transcription in human cancer cells, contributing to enhanced tumor cell proliferation. Based on these data, we hypothesize that DNA methylation of the EC-SOD promoter mediates silencing of this ..
  15. Rajvir Dahiya; Fiscal Year: 2015
    ..Alterations in cell growth will be assessed by monitoring cell proliferation, cell cycle distribution, apoptosis and in vitro invasion...
  16. Junxuan Lu; Fiscal Year: 2014
    ..We hypothesize that PGG prevents PCa by inhibiting cancer cell proliferation through distinct G1 and S arrest mechanisms, inducing p53-dependent and -independent apoptosis and by ..
  17. Charlotte Cunningham-Rundles; Fiscal Year: 2015
    ..as well as play a role in B cell differentiation in humans, thus we will examine how these may drive B cell proliferation and autoimmunity in CVID, especially when TACI signals are impaired...
  18. Ethanol Regulation of Serum Glucocorticoid Kinase I
    BLAIR N COSTIN; Fiscal Year: 2012
    ..stress pathways converge to control many cellular processes including receptor or ion channel trafficking, cell proliferation and/or apoptotic responses...
  19. Osteocalcin and Metabolic Risk Factors. The Framingham Study
    Yi Hsiang Hsu; Fiscal Year: 2011
    ..secreted by osteoblasts, may play a crucial role in endocrine regulation of energy metabolism by enhancing b-cell proliferation, insulin production, insulin sensitivity and adiponectin expression as a feedback loop of Leptin's ..
  20. Thomas L Clemens; Fiscal Year: 2016
    ..The contemporary view is that IGFs serve dominant roles in cell proliferation, survival and organismal growth, whereas insulin's primaryfunctionsinclude the regulation of fuel ..
  21. Dengue Infected Endothelial Cells Enhance Immune Cell Activation
    Erich R Mackow; Fiscal Year: 2013
    ..CXCL10/11 and RANTES secretion recruit and activate leukocytes and T-cells while IL-7 stimulates B, T and NK cell proliferation and T cell maturation...
  22. Yaya Wang; Fiscal Year: 2014
    ..I will also determine the role of PTPN22 in controlling antigen-specific T cell proliferation and activation...
  23. FOXP3-microRNA146-NFkB Axis in Tumor Suppression
    Lizhong Wang; Fiscal Year: 2013
    ..Accumulating data from others demonstrate that miR- 146a/b inhibit cancer cell proliferation, invasion, and metastasis in human cancers, including breast, prostate, pancreatic cancers and glioma...
  24. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011
    ..Clearly, estrogens that retain their beneficial effect on fat accumulation, but do not promote cell proliferation and cancer will have a profound impact on postmenopausal women...
  25. Cell signaling as a leukemia biomarker
    JAMES WILLIAM JACOBBERGER; Fiscal Year: 2013
    ..1) in a transcription factor that alters differentiation, and 2) in a signaling pathway protein that affects cell proliferation and/or apoptosis...
  26. Bioflavonoid Effects on EGF Signaling and Cell Cycle Pathways in Prostate Cancer
    BARRY MATTHEW MARKAVERICH; Fiscal Year: 2013
    ..type II [3H]estradiol binding sites with high affinity (Kd" 5nM) and inhibit normal and malignant prostate cell proliferation in vivo and in vitro...
  27. Nitric Oxide in Hemodialysis AV Fistula Maturation
    Richard A Cohen; Fiscal Year: 2010
    ..in nitric oxide function, oxidant production, and intracellular calcium control that dictate smooth muscle cell proliferation and migration that may predict failure of the AV fistula, and therefore provide therapeutic targets to ..
  28. Targeting AP-1 proteins in COPD
    SEKHAR M POTHIREDDY; Fiscal Year: 2010
    ..Abnormal lung cell proliferation and apoptosis, as well as extracellular matrix degradation, can alter lung cell homeostasis and architecture,..
  29. Anisa Shaker; Fiscal Year: 2016
    ..Epim-/- mice are partially protected from acute colitis in association with an increase in crypt cell proliferation. We have shown in a murine model of CAC that Epim-/- mice have markedly reduced dysplastic tumor burden...
  30. C Michael Hart; Fiscal Year: 2016
    ..in PPARg in the pulmonary vascular wall promote the expression of downstream mediators that cause vascular cell proliferation, remodeling and PH...
  31. Iris Z Jaffe; Fiscal Year: 2016
    ..a secreted peptide member of the vascular endothelial growth factor family and is known to promote vascular cell proliferation, monocyte chemotaxis, and inflammation by binding to the transmembrane receptor, fms-like tyrosine kinase (..
  32. Genistein and Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2010
    ..A panel of human prostate cell lines will be studies for cell proliferation, cell cycle, cyclin genes and apoptosis. Specific Aim # 2...
  33. Analysis of the role of the VRK1 protein kinase in mammalian fertility
    Paula Traktman; Fiscal Year: 2011
    ..The focus of this project is the VRK1 protein kinase, which is involved in the regulation of cell proliferation in organisms ranging from invertebrates to mammals. The VRK1 orthologs in Drosophila and C...
  34. Tatiana Efimova; Fiscal Year: 2014
    ..The p38 MAPK family members function in a cell type-specific and cell context-specific manner to regulate cell proliferation, differentiation, survival, inflammation, senescence and transformation...
  35. Richard J Bram; Fiscal Year: 2015
    ..p53, as well as decreased activation of Stat3, all of which have been implicated in regulation of cancer cell proliferation, suggesting a mechanism underlying the requirement for CypB in these tumor cells...
  36. SATDARSHAN SINGH MONGA; Fiscal Year: 2016
    ..hepatocytes displayed high expression at early hepatic developmental stages that coincide with ongoing cell proliferation and cell survival...
  37. Intermediary Metabolism, Histone Acetylation, and Transcriptional Regulation
    Ales Vancura; Fiscal Year: 2013
    ..chromatin structure and regulates diverse cellular functions, such as gene expression, DNA repair, and cell proliferation. Perturbation of the balanced action of histone acetyltransferases (HATs) and histone deacetylases (HDACs) ..
  38. RONALD JAY KOENIG; Fiscal Year: 2014
    ..The effects of PPFP on de novo fatty acid synthesis, cell proliferation and apoptosis will be assessed, to better understand the putative growth advantage brought about by PPFP...
  39. AIMALIE LYNNETTE HARDAWAY; Fiscal Year: 2014
    ..The Aim 2 is to determine how adipocyte and macrophage-derived CXCL1 and CXCL2 affect tumor cell proliferation, invasion, extracellular matrix degradation and cytokine profiles in vitro, and how the changes in tumor ..
  40. Aryl Hydrocarbon Receptor Modulators for the Treatment of Hepatocellular Carcinom
    Siva Kumar Kolluri; Fiscal Year: 2012
    ..will be screened further for their ability to induce AhR- dependent cell death and/or inhibition of cancer cell proliferation. The availability of numerous well- characterized AhR expressing and non-expressing cell culture models in ..
  41. Contribution of c-Jun N-terminal kinase activity to vestibular schwannoma growth
    Marlan R Hansen; Fiscal Year: 2013
    ..of ERKs and PI-3K/Akt in VS cells leading to increased proliferation and activation of JNK promoting cell proliferation and survival...
  42. Henryk F Urbanski; Fiscal Year: 2014
    ..vaccinia ankara as well as the seasonal influenza vaccine by measuring: 1) kinetics and magnitude of T and B cell proliferation;2) frequency of responding T cells;and 3) IgG antibody titer...
  43. Deregulated lipid metabolism in stroke
    Robert J Dempsey; Fiscal Year: 2013
    ..Hypothesis: D609 may block the cell cycle, attenuating neuronal death and non-neuronal cell proliferation by increasing ceramide levels after stroke...
  44. Mechanisms of ethanol-induced neurodevelopmental effects
    Marina Guizzetti; Fiscal Year: 2011
    ..alcohol exposure such as inhibition of the sonic hedgehog pathway, neuronal development and survival, and cell proliferation. Specific Aims of the proposal are: 1) The investigation of the role of ABCA1 and ABCG1 in ethanol-induced ..
  45. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..will identify the regions within the elastin molecule that trigger immune cell activation as determined by T cell proliferation and cytokine production...
  46. Heat Shock Effects on Human Mesenchymal Stem Cell Differentiation in Hydrogel
    Sihong Wang; Fiscal Year: 2010
    ..stem cells, it is important to investigate ways to enhance the qualitative and quantitative extent of stem cell proliferation and differentiation, and thus increase the chances for cells to grow into desired types of tissues or ..
  47. Fate of Lung Stem Cells During Pulmonary Disease
    Susan M Majka; Fiscal Year: 2012
    ..studies will determine whether inhibition of PDGFR2/abl kinase signaling decreases hypoxia-induced SP cell proliferation and differentiation or the vasoconstrictive effects of lung SP on the progression of PAH thru downstream ..
  48. Protein composition and interactions of telemeric chromatin
    Michael P Killoran; Fiscal Year: 2010
    ..for studying telomere chromatin in order to understand its role in stabilizing chromosomes and controlling cell proliferation. My proposal encompasses three aims each employing technically different approaches to accomplish this goal, ..
  49. IRON REGULATION OF GENE EXPRESSION
    ELIZABETH ANN LEIBOLD; Fiscal Year: 2013
    ..Increased knowledge of the mechanism by which IRP2 regulates iron balance and cell proliferation is important for developing therapeutics that can be used to target cancer cells and treat iron disorders.
  50. Hypertension and Collagen: Effect of Ac-SDKP
    Nour Eddine Rhaleb; Fiscal Year: 2010
    ..ACE inhibitors (ACEi) increase plasma Ac-SDKP, a negative regulator of cell proliferation present in plasma and tissue...
  51. Randomized trial of PEITC as a modifier of NNK metabolism in smokers
    Jian Min Yuan; Fiscal Year: 2012
    ..genotypes, and (2) to assess the effect PEITC supplementation (at 40 mg/day for 12 months) on reduction of cell proliferation (Ki-67) and induction of apoptosis (caspase-3 and TUNEL) in bronchial epithelia of current smokers...
  52. CLIFFORD JAMES ROSEN; Fiscal Year: 2015
    ..phosphorylated by ErbB2 a tyrosine kinase receptor that heterodimerizes with other ErbB receptors to enhance cell proliferation through the MAPK and PI3K pathways...
  53. GARY ANDREW WEISMAN; Fiscal Year: 2016
    ..e., cell proliferation and migration) and organization of acini into a functional gland structure (i.e...
  54. Jeanette Gowen Cook; Fiscal Year: 2016
    ..and precise DNA replication followed by accurate chromosome segregation is critical for controlling cell proliferation and genome stability...
  55. Regulation of apoptosis by PI 3-kinase/Akt signaling
    Geoffrey M Cooper; Fiscal Year: 2012
    ..The role of GSK-3 in gene regulation during cell proliferation will also be investigated. 3. Regulation of mRNA stability...
  56. Mechanisms of Early Growth Response Factor 1 (Egr-1) Induction by HSV-1 Lytic Inf
    SHAOCHUNG VICTOR HSIA; Fiscal Year: 2010
    ..point for many signaling cascades and is known to play an important role in regulating inflammation, cell proliferation and apoptosis...
  57. Beta-cell Proliferation
    Fredric E Wondisford; Fiscal Year: 2013
    ..by applicant): The overall goal of this proposal is to define mechanisms governing pancreatic [unreadable]-cell proliferation. Variations in insulin demand resulting from physiological and pathological states require adaptive ..
  58. Rajvir Dahiya; Fiscal Year: 2014
    ..expression of a set of miRNAs in human prostate cancer tissues and also analyze whether miRNAs can regulate cell proliferation and progression using prostate cancer cell lines...
  59. Link of beta cell proliferation and type 2 diabetes to epigenetic regulation
    Xianxin Hua; Fiscal Year: 2013
    ..Enhancing beta cell proliferation or regeneration can be an effective means to treat type 2 diabetes (T2D)...
  60. Marc B Hershenson; Fiscal Year: 2015
    ..2. Examine the effects of matricellular protein expression on neonatal lung mesenchymal stromal cell proliferation and differentiation, as well as the roles of glycogen synthase kinase (GSK)-3[unreadable] and [unreadable]-..
  61. Natarajan Muthusamy; Fiscal Year: 2015
    ..relevant targets and more importantly to target simultaneously several genes involved in pathways regulating cell proliferation, differentiation and survival...
  62. Vincent W Yang; Fiscal Year: 2016
    ..KLF4 is a potent inhibitor of cell proliferation in vitro and does so by eliciting several cell cycle checkpoint responses...
  63. NADPH oxidase-associated transition from Barrett's esophagus to adenocarcinoma
    Weibiao Cao; Fiscal Year: 2013
    ..NOX5-S-derived ROS contribute to increased cell proliferation and decreased apoptosis in SEG1 cells...
  64. Site-directed Chemotherapy for Breast Cancer using Novel Angiogenesis Inhibitor
    Shaker A Mousa; Fiscal Year: 2010
    ..the thyroid hormones such as 3,5,3'-triiodo-L-thyronine (T3) and L-Thyroxine (T4) can stimulate cancer cell proliferation and thus act as growth factors...
  65. TRANSCRIPTIONAL CONTROL OF MAMMALIAN BRAIN DEVELOPMENT
    Eseng Lai; Fiscal Year: 2001
    ..BrdU labeling and in situ hybridizations suggest reduced cell proliferation, precocious expression of neuronal marker gene, and reduced expression of sonic hedgehog (shh)...
  66. Bile acid-induced colon cancer cell proliferation
    Jean Pierre Raufman; Fiscal Year: 2009
    The central hypothesis to be tested in this proposal is that bile acids induce colon cancer cell proliferation by interaction with M3 muscarinic receptors (M3R), thereby causing transactivation of epidermal growth factor receptors (EGFR)...
  67. Anti-HLA Antibody Activation of Endothelial Cells in Cardiac Transplantation
    Elaine F Reed; Fiscal Year: 2010
    ..signals in endothelial cells that synergize with growth factor receptors to elicit cell survival and cell proliferation. Activation of anti-apoptotic and cell survival machinery in endothelial cells is augmented when cells are ..
  68. Mechanism of HTLV-1 Tax-mediated activation of CDK6 transcription.
    ISABELLE MICHELE LEMASSON; Fiscal Year: 2010
    ..propagation by activating transcription of the chromosomally integrated HTLV-1 genome and by stimulating cell proliferation, which both serve to replicate the viral genome...
  69. Molecular Determinants Affecting FLT-PET in Colorectal Cancer
    HENRY C MANNING; Fiscal Year: 2010
    ..Many molecularly targeted therapies are designed to reduce tumor cell proliferation. Conventional methods to assess tumor cell proliferation require invasive procurement of limited amounts of ..
  70. ESTOGENS, DIETARY ENERGY AND PITUITARY TUMORIGENESIS
    James Shull; Fiscal Year: 2002
    Estrogens play a central role in the regulation of cell proliferation in numerous mammalian tissues and are inextricably implicated in the etiology of several major human cancers...
  71. PROGESTERONE, CELL CYCLE AND CANCER
    Jeffrey Pollard; Fiscal Year: 2005
    ..Progesterone acts to oppose the effects of estrogen on cell proliferation and, consequently, it is used in the treatment of endometrial cancer and it is an essential component of ..
  72. HUMAN GASTRIN-RELEASING PEPTIDE RECEPTOR GENE REGULATION
    Horst Weber; Fiscal Year: 2004
    ..The human GRP-R (hGRP-R) also mediates potent signals of cell proliferation in human intestinal and extraintestinal cells both in vivo and in vitro...