Genomes and Genes
Summary: A condition of decreased oxygen content at the cellular level.
Publications260 found, 100 shown here
- Hypoxia--a key regulatory factor in tumour growthAdrian L Harris
Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
Nat Rev Cancer 2:38-47. 2002..Many elements of the hypoxia-response pathway are therefore good candidates for therapeutic targeting...
- Notch signaling mediates hypoxia-induced tumor cell migration and invasionCecilia Sahlgren
Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Proc Natl Acad Sci U S A 105:6392-7. 2008..In sum, these data demonstrate a complex integration of the hypoxia and Notch signaling pathways in regulation of EMT and open up perspectives for pharmacological intervention with hypoxiainduced EMT and cell invasiveness in tumors...
- HIF-1 and HIF-2 transcription factors--similar but not identicalAgnieszka Loboda
Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
Mol Cells 29:435-42. 2010..Finally, recent data showing link between HIFs and specific microRNA have been presented...
- Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tensionG L Wang
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287 3914, USA
Proc Natl Acad Sci U S A 92:5510-4. 1995....
- Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylationP Jaakkola
The Henry Wellcome Building of Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Science 292:468-72. 2001..An absolute requirement for dioxygen as a cosubstrate and iron as cofactor suggests that HIF-PH functions directly as a cellular oxygen sensor...
- Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1J A Forsythe
Department of Physiology, University of Maryland School of Medicine, Baltimore, 21201, USA
Mol Cell Biol 16:4604-13. 1996..VEGF mRNA was not induced by hypoxia in mutant cells that do not express the HIF-1beta (ARNT) subunit. These findings implicate HIF-1 in the activation of VEGF transcription in hypoxic cells...
- The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysisP H Maxwell
Wellcome Trust Centre for Human Genetics, Oxford, UK
Nature 399:271-5. 1999..Thus, constitutive HIF-1 activation may underlie the angiogenic phenotype of VHL-associated tumours. The pVHL/HIF-1 interaction provides a new focus for understanding cellular oxygen sensing...
- A microRNA signature of hypoxiaRitu Kulshreshtha
Molecular Oncology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Mol Cell Biol 27:1859-67. 2007..Interestingly, the vast majority of hypoxia-induced microRNAs are also overexpressed in a variety of human tumors...
- HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensingM Ivan
Dana Farber Cancer Institute and Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
Science 292:464-8. 2001..Because proline hydroxylation requires molecular oxygen and Fe(2+), this protein modification may play a key role in mammalian oxygen sensing...
- Hypoxia-inducible factors and the response to hypoxic stressAmar J Majmundar
Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Mol Cell 40:294-309. 2010..These transcription factors function in normal tissue homeostasis and impinge on critical aspects of disease progression and recovery. Insights from basic HIF biology are being translated into pharmaceuticals targeting the HIF pathway...
- Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1Daniel J Ceradini
Laboratory of Microvascular Research and Vascular Tissue Engineering, Institute of Reconstructive Plastic Surgery, New York University School of Medicine, New York, New York 10016, USA
Nat Med 10:858-64. 2004..These data show that the recruitment of CXCR4-positive progenitor cells to regenerating tissues is mediated by hypoxic gradients via HIF-1-induced expression of SDF-1...
- Hypoxia in cancer: significance and impact on clinical outcomePeter Vaupel
Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, 55099 Mainz, Germany
Cancer Metastasis Rev 26:225-39. 2007..g., different immunohistochemical staining procedures) may compromise the power of the prognostic parameter used...
- Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiationXin Huang
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA 94025, USA
Mol Cell 35:856-67. 2009..Taken together, these data implicate an important role for mir-210 in regulating the hypoxic response of tumor cells and tumor growth...
- MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3Pasquale Fasanaro
Laboratorio di Patologia Vascolare, Istituto Dermopatico dell Immacolata, IRCCS, 00167 Rome
J Biol Chem 283:15878-83. 2008..We conclude that miR-210 up-regulation is a crucial element of endothelial cell response to hypoxia, affecting cell survival, migration, and differentiation...
- Targeting hypoxia in cancer therapyWilliam R Wilson
Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand
Nat Rev Cancer 11:393-410. 2011..We address the particular challenges and opportunities these overlapping strategies present, and discuss the central importance of emerging diagnostic tools for patient stratification in targeting hypoxia...
- HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasionRose Du
Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Cancer Cell 13:206-20. 2008..VEGF also directly regulates tumor cell invasiveness. When VEGF activity is impaired, tumor cells invade deep into the brain in the perivascular compartment...
- Oxygen in stem cell biology: a critical component of the stem cell nicheAhmed Mohyeldin
Department of Neurosurgery and Oncology, Brain Tumor Stem Cell Laboratory, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA
Cell Stem Cell 7:150-61. 2010..These findings have important implications on our understanding of development, disease, and tissue-engineering practices and furthermore elucidate an added dimension of stem cell control within the niche...
- The impact of O2 availability on human cancerJessica A Bertout
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Nat Rev Cancer 8:967-75. 2008..The central role played by intra-tumoural hypoxia and HIF in these processes has made them attractive therapeutic targets in the treatment of multiple human malignancies...
- Hypoxia-inducible factors, stem cells, and cancerBrian Keith
Abramson Family Cancer Research Institute, University of Pennsylvania, 453 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Cell 129:465-72. 2007..As many cancers are thought to develop from a small number of transformed, self-renewing, and multipotent "cancer stem cells," these results suggest new roles for HIFs in tumor progression...
- HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxiaJung whan Kim
Graduate Program of Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cell Metab 3:177-85. 2006..These studies reveal a hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production...
- Oxygen sensing by HIF hydroxylasesChristopher J Schofield
The Oxford Centre for Molecular Sciences and The Dyson Perrins Laboratory, Department of Chemistry, South Parks Road, Oxford OX1 3QY, UK
Nat Rev Mol Cell Biol 5:343-54. 2004
- Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1Weibo Luo
Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 145:732-44. 2011..Thus, PKM2 participates in a positive feedback loop that promotes HIF-1 transactivation and reprograms glucose metabolism in cancer cells...
- Hypoxia, HIF1 and glucose metabolism in the solid tumourNicholas C Denko
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Rev Cancer 8:705-13. 2008..As discussed in this Perspective, new data suggests that this metabolic switch may provide a benefit to the tumour not by increasing glycolysis but by decreasing mitochondrial activity...
- Exploiting tumour hypoxia in cancer treatmentJ Martin Brown
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford, California 94305, USA
Nat Rev Cancer 4:437-47. 2004
- Lysyl oxidase is essential for hypoxia-induced metastasisJanine T Erler
Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA
Nature 440:1222-6. 2006..Furthermore, LOX may be required to create a niche permissive for metastatic growth. Our findings indicate that LOX is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases...
- HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expressionE Laughner
Institute of Genetic Medicine, Departments of Pediatrics and Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-3914, USA
Mol Cell Biol 21:3995-4004. 2001..These data provide a molecular basis for VEGF induction and tumor angiogenesis by heregulin-HER2 signaling and establish a novel mechanism for the regulation of HIF-1alpha expression...
- HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growthKelly L Covello
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Genes Dev 20:557-70. 2006....
- Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cellsZhizhong Li
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA
Cancer Cell 15:501-13. 2009..Our results demonstrate that GSCs differentially respond to hypoxia with distinct HIF induction patterns, and HIF2alpha might represent a promising target for antiglioblastoma therapies...
- NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alphaJordi Rius
Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0723, USA
Nature 453:807-11. 2008..IKK-beta is also essential for HIF-1alpha accumulation in macrophages experiencing a bacterial infection. Hence, IKK-beta is an important physiological contributor to the hypoxic response, linking it to innate immunity and inflammation...
- Drug resistance and the solid tumor microenvironmentOlivier Tredan
Division of Applied Molecular Oncology and Department of Medical Oncology and Hematology, Princess Margaret Hospital, 610 University Ave, Toronto, ON M5G 2M9, Canada
J Natl Cancer Inst 99:1441-54. 2007....
- MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxiaZhong Hua
Life Science Division, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China
PLoS ONE 1:e116. 2006..The competitive principle, differential regulation, multi-miRNA binding sites, and false positive miRNAs might be useful strategies in the avoidance of unwanted cross-action among genes targeted by miRNAs with multiple targets...
- MicroRNA-210: a unique and pleiotropic hypoxamirStephen Y Chan
Harvard Medical School Boston, MA
Cell Cycle 9:1072-83. 2010..Thus, reflecting the pleiotropic actions of HIF-α, miR-210 appears to function as a "master microRNA" relevant for the control of diverse functions in the hypoxic state...
- Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1G L Semenza
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 3914, USA
Annu Rev Cell Dev Biol 15:551-78. 1999..HIF-1 thus appears to function as a master regulator of O2 homeostasis that plays essential roles in cellular and systemic physiology, development, and pathophysiology...
- Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granulesBenjamin J Moeller
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
Cancer Cell 5:429-41. 2004..These data describe novel pathways contributing significantly to our understanding of HIF-1 regulation which may be major determinants of tumor radiosensitivity, potentially having high clinical relevance...
- Hypoxia signalling through mTOR and the unfolded protein response in cancerBradly G Wouters
Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
Nat Rev Cancer 8:851-64. 2008....
- MicroRNA regulation of DNA repair gene expression in hypoxic stressMeredith E Crosby
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
Cancer Res 69:1221-9. 2009....
- miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activityM P Puissegur
Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR6097, Sophia Antipolis, France
Cell Death Differ 18:465-78. 2011..These observations help explain contradictory data regarding miR-210 expression and its putative function in solid tumors...
- The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotypeJohn M Heddleston
Department of Stem Cell Biology and Regenerative Medicine, Cleveland Clinic, Cleveland, OH, USA
Cell Cycle 8:3274-84. 2009....
- The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5Kasper M A Rouschop
Department of Radiation Oncology Maastro Lab, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
J Clin Invest 120:127-41. 2010..Our data therefore demonstrate that the UPR is an important mediator of the hypoxic tumor microenvironment and that it contributes to resistance to treatment through its ability to facilitate autophagy...
- A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activationG L Semenza
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Mol Cell Biol 12:5447-54. 1992..We have thus defined a functionally tripartite, 50-nt hypoxia-inducible enhancer which binds several nuclear factors, one of which is induced by hypoxia via de novo protein synthesis...
- Direct regulation of TWIST by HIF-1alpha promotes metastasisMuh Hwa Yang
Institutes of Biochemistry and Molecular Biology, National Yang Ming University, No 155, Sec 2, Li Niong Street, Peitou, Taipei 112, Taiwan
Nat Cell Biol 10:295-305. 2008..These results provide evidence of a key signalling pathway involving HIF-1alpha and TWIST that promotes metastasis in response to intratumoural hypoxia...
- Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycinChristine C Hudson
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Mol Cell Biol 22:7004-14. 2002..These studies position mTOR as an upstream activator of HIF-1 function in cancer cells and suggest that the antitumor activity of rapamycin is mediated, in part, through the inhibition of cellular responses to hypoxic stress...
- Hypoxia and cancerM Christiane Brahimi-Horn
Institute of Signaling, Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Centre A Lacassagne, 33 Avenue Valombrose, 06189, Nice, France
J Mol Med (Berl) 85:1301-7. 2007..It is hoped that a better understanding of the mechanisms implicated will lead to alternative and more efficient therapeutic approaches...
- Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signalingRyota Uemura
Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, OH 45267 0529, USA
Circ Res 98:1414-21. 2006..Preconditioning of BMSCs enhanced their survival and ability to attenuate LV remodeling, which was attributable, in part, to paracrine effects...
- HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cellsRyo Fukuda
Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 129:111-22. 2007..Thus, mammalian cells respond to hypoxia by altering COX subunit composition, as previously observed in yeast, but by a completely different molecular mechanism...
- Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1alphaA Soeda
Brain Tumor Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
Oncogene 28:3949-59. 2009..This study illustrates the importance of the tumor microenvironment in determining cellular behavior...
- Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domainsGregory Bellot
Institute of Developmental Biology and Cancer Research, University of Nice, CNRS UMR 6543, Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France
Mol Cell Biol 29:2570-81. 2009..Hypoxia-induced autophagy via BNIP3 and BNIP3L is clearly a survival mechanism that promotes tumor progression...
- Ischemic preconditioning augments survival of stem cells via miR-210 expression by targeting caspase-8-associated protein 2Ha Won Kim
Department of Pathology, University of Cincinnati, Cincinnati, Ohio 45267, USA
J Biol Chem 284:33161-8. 2009..These results highlighted that IP by multiple short episodes of I/R is a novel strategy to promote stem cell survival...
- Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulationCheng Jun Hu
Abramson Family Cancer Research Institute Howard Hughes Medical Institute, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Mol Cell Biol 23:9361-74. 2003..Importantly, HIF-1alpha (and not HIF-2alpha) stimulates glycolytic gene expression in both types of cells, clearly showing for the first time that HIF-1alpha and HIF-2alpha have unique targets...
- HIF-1 alpha is required for solid tumor formation and embryonic vascularizationH E Ryan
Department of Biology, University of California, San Diego, La Jolla, CA 92093 0366, USA
EMBO J 17:3005-15. 1998..These data demonstrate the essential role of HIF-1alpha in controlling both embryonic and tumorigenic responses to variations in microenvironmental oxygenation...
- MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNTZhan Zhang
Rosetta Inpharmatics LLC, Seattle, WA, USA
Cell Cycle 8:2756-68. 2009..Thus, miR-210 influences the hypoxia response in tumor cells through targeting a key transcriptional repressor of the MYC-MAX network...
- Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathwaysGareth P Elvidge
Oxygen Sensing Group, The Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford OX3 7BN
J Biol Chem 281:15215-26. 2006..Nevertheless, the definition of genes regulated by both hypoxia and DMOG, but not HIF, distinguished other pathways most likely involving the action of 2-OG-dependent dioxygenases on non-HIF substrates...
- Biology of HIF-1alphaA Weidemann
Division of Biological Sciences, Molecular Biology Section, University of California, San Diego, La Jolla, CA 92093, USA
Cell Death Differ 15:621-7. 2008..The transcriptional complex hypoxia-inducible factor has emerged as a key regulator of the molecular hypoxic response, mediating a wide range of physiological and cellular mechanisms necessary to adapt to reduced oxygen...
- Low O2 tensions and the prevention of differentiation of hES cellsToshihiko Ezashi
Department of Animal Sciences, University of Missouri, Columbia, MO 65211, USA
Proc Natl Acad Sci U S A 102:4783-8. 2005..In addition, hES cell growth under hypoxia provided enhanced formation of embryoid bodies. Hypoxic culture would appear to be necessary to maintain full pluripotency of hES cells...
- Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathwaysNadine Rohwer
Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Berlin, Germany
Drug Resist Updat 14:191-201. 2011..Specifically, we will highlight the multifaceted interaction of HIF with apoptosis, senescence, autophagy, p53 and mitochondrial activity and outline how these are at the heart of HIF-mediated therapy failure...
- Reactive species mechanisms of cellular hypoxia-reoxygenation injuryChuanyu Li
Department of Veterans Affairs Medical Center, Birmingham 35233, USA
Am J Physiol Cell Physiol 282:C227-41. 2002..This review focuses on the specific roles of ROS and RNS in the cellular response to hypoxia and subsequent cytolytic injury during reoxygenation...
- Hypoxia-driven selection of the metastatic phenotypeRichard Sullivan
Department of Anatomy and Cell Biology, Queen s University, Kingston, ON K7L 3N6, Canada
Cancer Metastasis Rev 26:319-31. 2007..Through regulation of these critical molecular targets, hypoxia promotes each step of the metastatic cascade and selects tumor cell populations that are able to escape the unfavorable microenvironment of the primary tumor...
- HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activityJohn D Gordan
Abramson Family Cancer Research Institute, School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Cancer Cell 11:335-47. 2007..Enhanced c-Myc activity likely contributes to HIF-2alpha-mediated neoplastic progression following loss of the VHL tumor suppressor and influences the behavior of hypoxic tumor cells...
- Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosaEric T Clambey
Department of Anesthesiology, University of Colorado School of Medicine, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 109:E2784-93. 2012..These studies demonstrate that hypoxia is an intrinsic molecular cue that promotes FoxP3 expression, in turn eliciting potent anti-inflammatory mechanisms to limit tissue damage in conditions of reduced oxygen availability...
- Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alphaJi Hong Lim
Department of Pharmacology, Ischemic Hypoxic Disease Institute, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
Mol Cell 38:864-78. 2010..Our results suggest that crosstalk between oxygen- and redox-responsive signal transducers occurs through the SIRT1-HIF-1alpha interaction...
- Passing the baton: the HIF switchMei Yee Koh
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Trends Biochem Sci 37:364-72. 2012..Here, we review the significance of the HIF switch and the relation between HIF-1 and HIF-2 under both physiological and pathophysiological conditions...
- Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomesJung Eun Park
School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore
Mol Cell Proteomics 9:1085-99. 2010..Two tetraspanins, CD9 and CD81, co-immunoprecipitated. Together, these data suggested that tumor cells secrete proteins and exosomes with the potential to modulate their microenvironment and facilitate angiogenesis and metastasis...
- Genome-wide association of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha DNA binding with expression profiling of hypoxia-inducible transcriptsDavid R Mole
Henry Wellcome Building of Molecular Physiology, University of Oxford, Oxford OX3 7BN, United Kingdom
J Biol Chem 284:16767-75. 2009..Given emerging evidence for biologically distinct functions of HIF-1alpha versus HIF-2alpha understanding the mechanisms restricting HIF-2alpha activity will be of interest...
- HIF induces human embryonic stem cell markers in cancer cellsJulie Mathieu
Department of Biochemistry, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA
Cancer Res 71:4640-52. 2011..In primary glioma-derived CD133 negative cells, hypoxia was able to induce neurospheres and hESC markers. Together, these findings suggest that HIF targets may act as key inducers of a dynamic state of stemness in pathologic conditions...
- P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesisMunekazu Yamakuchi
Department of Medicine, Aab Cardiovascular Research Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 107:6334-9. 2010..Finally, in human colon cancer specimens, expression of miR-107 is inversely associated with expression of HIF-1beta. Taken together these data suggest that miR-107 can mediate p53 regulation of hypoxic signaling and tumor angiogenesis...
- MicroRNA-210 as a novel therapy for treatment of ischemic heart diseaseShijun Hu
Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305 5111, USA
Circulation 122:S124-31. 2010..We hypothesize that microRNA-210 can rescue cardiac function after myocardial infarction by upregulation of angiogenesis and inhibition of cellular apoptosis in the heart...
- Hypoxia inhibits senescence and maintains mesenchymal stem cell properties through down-regulation of E2A-p21 by HIF-TWISTChih Chien Tsai
Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
Blood 117:459-69. 2011..These results support low-density hypoxic culture as a method for efficiently expanding MSCs without losing stem cell properties or increasing tumorigenicity...
- Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center studyMarianne Nordsmark
Department of Experimental Clinical Oncology, Aarhus University Hospital, DK, Denmark
Radiother Oncol 77:18-24. 2005..To analyze the relationship between pre-treatment measurements of tumor oxygen tension (pO2) and survival in advanced head and neck cancer...
- Interdependence of hypoxic and innate immune responsesVictor Nizet
Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Nat Rev Immunol 9:609-17. 2009..In turn, HIF-driven innate immune responses have important consequences for both the pathogen and the host, such that the tissue microenvironment fundamentally influences susceptibility to infectious disease...
- Tumor hypoxia: definitions and current clinical, biologic, and molecular aspectsM Hockel
Department of Obstetrics and Gynecology, University of Leipzig, Germany
J Natl Cancer Inst 93:266-76. 2001..Instead, alternative definitions based on clinical, biologic, and molecular effects that are observed at O(2) partial pressures below a critical level have to be applied...
- Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancersJen Tsan Chi
Department of Biochemistry, Stanford University School of Medicine, Palo Alto, California, United States of America
PLoS Med 3:e47. 2006....
- Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapyH Harada
Department of Radiation Oncology and Image Applied Therapy, Kyoto University Graduate School of Medicine, Sakyo ku, Japan
Br J Cancer 100:747-57. 2009....
- Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1Elhadji M Dioum
Veterans Affairs North Texas Health Care System, Department of Medicine, 4500 South Lancaster Road, Dallas, TX 75216, USA
Science 324:1289-93. 2009..Thus, Sirt1 promotes HIF-2 signaling during hypoxia and likely other environmental stresses...
- Tumor hypoxia and cancer progressionJie Zhou
Institute of Biochemistry I, Faculty of Medicine, Johann Wolfgang Goethe University, Theodor Stern Kai 7, 60590 Frankfurt, Germany
Cancer Lett 237:10-21. 2006....
- Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epitheliaKristin Synnestvedt
Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 110:993-1002. 2002..These results identify an HIF-1-dependent regulatory pathway for CD73 and indicate the likelihood that CD39/CD73 protects the epithelial barrier during hypoxia...
- An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxiaYair Benita
Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Nucleic Acids Res 37:4587-602. 2009..Together these analyses demonstrate the potential to recover novel HIF-1-target genes and the discovery of mammalian-regulatory elements operative in the context of microarray data sets...
- Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxiaRui Hua Xu
Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Res 65:613-21. 2005..Because the Warburg effect and hypoxia are frequently seen in human cancers, these findings may have broad clinical implications...
- Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancerJohan Bussink
Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Netherlands
Lancet Oncol 9:288-96. 2008..Thus, the activation status of this pathway might be a key element for the prediction of treatment response and for therapeutic targeting in head and neck cancer...
- Anti-apoptotic role of HIF-1 and AP-1 in paclitaxel exposed breast cancer cells under hypoxiaLionel Flamant
Laboratory of Biochemistry and Cellular Biology URBC, NARILIS NAmur Research Institute for LIfe Sciences FUNDP University of Namur, 5000 Namur, Belgium
Mol Cancer 9:191. 2010..Hypoxia is a hallmark of solid tumors and is associated with metastases, therapeutic resistance and poor patient survival...
- Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site predictionAmaya Ortiz-Barahona
Department of Biochemistry, Universidad Autónoma de Madrid Instituto de Investigaciones Biomédicas CSIC, Madrid, Spain
Nucleic Acids Res 38:2332-45. 2010....
- Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy responseMark W Dewhirst
Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA
Nat Rev Cancer 8:425-37. 2008..HIF1 can then promote endothelial and tumour cell survival. As discussed here, a constant theme emerges: inhibition of HIF1 activity will have therapeutic benefit...
- Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transitionDebra F Higgins
Department of Medicine, Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Clin Invest 117:3810-20. 2007....
- Theoretical simulation of tumour oxygenation and results from acute and chronic hypoxiaAlexandru Daşu
Department of Radiation Sciences, Umea University, S 901 85 Umea, Sweden
Phys Med Biol 48:2829-42. 2003..All these suggest that theoretical modelling of tissue oxygenation starting from the basic principles is a robust method that can be used to quantify the tissue oxygenation and to provide input parameters for other simulations...
- Hypoxia signalling in cancer and approaches to enforce tumour regressionJacques Pouyssegur
Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR 6543, University of Nice, Centre Antoine Lacassagne, 33 Avenue Valombrose, 06189 Nice, France
Nature 441:437-43. 2006..There are new approaches to enforce necrotic cell death and tumour regression by targeting tumour metabolism and pH(i)-control systems...
- Hypoxia-inducible factors as essential regulators of inflammationHongxia Z Imtiyaz
Abramson Family Cancer Research Institute, University of Pennsylvania, 438 BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104 6160, USA
Curr Top Microbiol Immunol 345:105-20. 2010..We will also discuss how hypoxia and HIFs control properties of tumor-associated macrophages and their relationship to tumor formation and progression...
- A hypoxia-induced positive feedback loop promotes hypoxia-inducible factor 1alpha stability through miR-210 suppression of glycerol-3-phosphate dehydrogenase 1-likeTimothy J Kelly
Department of Cancer Biology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA
Mol Cell Biol 31:2696-706. 2011..We propose a model in which hypoxia-induced miR-210 represses GPD1L, contributing to suppression of PHD activity, and increases of HIF-1α protein levels...
- Tumor microenvironmental physiology and its implications for radiation oncologyPeter Vaupel
Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
Semin Radiat Oncol 14:198-206. 2004..Because of a relatively high risk of local relapse or distant metastasis, patients with hypoxic and/or "high-lactate" tumors should undergo close surveillance...
- Hypoxia, inflammation, and the tumor microenvironment in metastatic diseaseElizabeth C Finger
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University, Stanford, CA, USA
Cancer Metastasis Rev 29:285-93. 2010..Central players involved in this process and discussed in this review include integrins, matrix metalloproteinases, and soluble growth factors/matrix proteins, including the connective tissue growth factor and lysyl oxidase...
- Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcomaD M Brizel
Department of Radiation Oncology, Duke University Comprehensive Cancer Center, Durham, North Carolina, 27710, USA
Cancer Res 56:941-3. 1996..Median pO2 was 7.5 mm Hg for metastasizing tumors versus 20 mm Hg for nonmetastasizing tumors (P=0.03). Potential mechanisms and implications for clinical trial design are discussed...
- Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activityEoin P Cummins
Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
Proc Natl Acad Sci U S A 103:18154-9. 2006....
- Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanismsT Kinnaird
Cardiovascular Research Institute, Washington Hospital Center, Washington, DC 20010, USA
Circ Res 94:678-85. 2004..These data indicate that paracrine signaling is an important mediator of bone marrow cell therapy in tissue ischemia, and that cell incorporation into vessels is not a prerequisite for their effects...
- Stabilization of wild-type p53 by hypoxia-inducible factor 1alphaW G An
Department of Cell and Cancer Biology, Medicine Branch, NCI, NIH, Bethesda, Maryland 20892, USA
Nature 392:405-8. 1998..Our results suggest that hypoxic induction of transcriptionally active wild-type p53 is achieved as a result of the stabilization of p53 by its association with HIF-1alpha...
- Clinical and biological factors affecting response to radiotherapy in patients with head and neck cancer: a reviewP Silva
Academic Department of Radiation Oncology, The University of Manchester, Manchester, UK
Clin Otolaryngol 32:337-45. 2007....
- HIF-1alpha and cancer therapyMei Yee Koh
Department of Experimental Therapeutics, M D Anderson Cancer Center, Houston, TX 77030, USA
Recent Results Cancer Res 180:15-34. 2010..In this chapter, we summarize recent findings regarding the regulation of HIF-1alpha and the progress made in identifying new therapeutic agents that inhibit HIF-1alpha...
- DNA cross-links in human tumor cells exposed to the prodrug PR-104A: relationships to hypoxia, bioreductive metabolism, and cytotoxicityRachelle S Singleton
Auckland Cancer Society Research Centre, The University of Auckland, Auckland, New Zealand
Cancer Res 69:3884-91. 2009....
- Adipose stromal cells stimulate angiogenesis via promoting progenitor cell differentiation, secretion of angiogenic factors, and enhancing vessel maturationKseniya Rubina
Department of Biological and Medical Chemistry, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow, Russia
Tissue Eng Part A 15:2039-50. 2009..All these mechanisms of actions could be beneficial for the stimulation of angiogenesis in ischemic tissues by ASCs administration...
- Hypoxia and the malignant glioma microenvironment: regulation and implications for therapyL Oliver
Institut de Recherche Thérapeutique de l Université de Nantes, CRCNA INSERM UMR892 Université de Nantes, Nantes Cedex 1, France
Curr Mol Pharmacol 2:263-84. 2009..In this review we will summarize the role of hypoxia in GBM with regard to drug therapy and toxicity and attempt to describe the possible interactions between hypoxia and apoptosis...
- SUMOylation participates in induction of ischemic toleranceYang ja Lee
Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
J Neurochem 109:257-67. 2009..These findings suggest that maintenance of a globally elevated SUMO-1 (and maybe SUMO-2/3) conjugation level as revealed by immunoblot assays is a component of ischemic tolerance...
- Hypoxia-inducible factors: central regulators of the tumor phenotypeJohn D Gordan
Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, PA, USA
Curr Opin Genet Dev 17:71-7. 2007..New targets and novel mechanisms of dysregulation place the HIFs in an ever more central role in tumor biology and have led to development of pharmacological inhibitors of their activity...
- Hypoxic chondrogenic differentiation of human embryonic stem cells enhances cartilage protein synthesis and biomechanical functionalityE J Koay
Department of Bioengineering, Rice University, Houston, TX 77251 1892, USA
Osteoarthritis Cartilage 16:1450-6. 2008..Hypoxia has effects on many cellular processes, though few investigations with hypoxia provide quantitative functional data on engineered cartilage...
- Mechanisms of adaptive angiogenesis to tissue hypoxiaGuo Hua Fong
Center for Vascular Biology, Department of Cell Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3501, USA
Angiogenesis 11:121-40. 2008....
- Predicting Radiation Response by Tumor pO2Cameron Koch; Fiscal Year: 2006..DDFP may thus be the first PFC emulsion practical and safe for use in multifraction clinical regimens. ..
- IMAGING T CELLS BY POSITRON EMISSION TOMOGRAPHYShahriar Yaghoubi; Fiscal Year: 2013..T-cell hypoxia will be assessed by introducing a molecular sensor for oxygen to test whether sr39tk can report low oxygen ..
- MR Dynamic Imaging and Spectroscopy in Head & Neck CancersAMITA DAVE; Fiscal Year: 2010..Microenvironment parameters that have shown to be relevant for treatment outcome include tumor cell hypoxia and proliferation...
- Exploiting tumor stroma interactions for cancer therapyGarth Powis; Fiscal Year: 2013..of the pancreatic cancer cell to hypoxia to develop novel small molecule inhibitors that can break the tumor cell hypoxia/stroma desmoplasia cycle leading to new and more effective ways of treating pancreatic cancer...
- TUMOR PHYSIOLOGICAL EFFECTS OF ANGIOGENESIS INHIBITIONWilliam Lee; Fiscal Year: 2002..treated tumors reveals that a mechanism by which it controls tumor growth involves induction of severe tumor cell hypoxia and hypoxia-induced apoptosis...
- Regulation of Renal Oxygenation and Blood PressurePin Lan Li; Fiscal Year: 2006..found highly expressed in the renal medulla and upregulated in response to decrease in tissue oxygenation or cell hypoxia. Inhibition of HIF-1alpha in this kidney region resulted in increase in arterial blood pressure and enhancement ..
- MRI BIOMARKERS OF ANGIOGENESIS AND CELL INJURY IN RETINOPATHY OF PREMATURITYJunjie Chen; Fiscal Year: 2009..if successful, will provide novel MRI biomarkers for early diagnosis of retinal neovascularization that feature cell hypoxia and angiogenesis...
- Endothelial Cell Hypoxia Tolerance: Role of PlasmalogensHarrison Farber; Fiscal Year: 2006..Once the biochemistry of plasmalogens in EC has been clarified, studies to determine their biological importance can be undertaken. [unreadable] [unreadable]..
- ENDOTHELIAL CELL HYPOXIA ASSOCIATED PROTEINSHarrison Farber; Fiscal Year: 2000....
- Hypoxia-Inducible Factor 1 and Oxygen HomeostasisGregg Semenza; Fiscal Year: 2009....
- EXPRESSION OF HUMAN ERYTHROPOIETIN GENEGregg Semenza; Fiscal Year: 2002..abstract_text> ..
- DEVELOPMENT OF NEW HYPOXIC CYTOTOXINS FOR CANCER THERAPYJohn Brown; Fiscal Year: 2008..abstract_text> ..
- Yeast Gene Ontology by Phenotypic ProfilingJohn Brown; Fiscal Year: 2007..abstract_text> ..
- Experimental Radiotherapy and Chemotherapy With a Potent New Hypoxic CytotoxinJOHN MARTIN BROWN; Fiscal Year: 2010....
- EXPERIMENTAL RADIOTHERAPY--BASIS AND MODIFICATIONJohn Brown; Fiscal Year: 2002..To test this hypothesis we will employ inhibitors of the topo II catalytic cycle as well as cells induced to express high levels of topo II following TPZ treatment ..
- Interactions of Black Cohosh with Cancer TherapySara Rockwell; Fiscal Year: 2005..This project will assess these possibilities. The findings will show whether this herb is inactive and harmless, potentially dangerous to breast cancer patients, or of potential value in the treatment of this disease. ..
- Monitoring Oxygen Repeatedly for Hypoxic Tumor TherapyMohammad Khan; Fiscal Year: 2007..If successful, this approach potentially could be immediately extended for clinical applications. [unreadable] [unreadable] [unreadable]..
- Development of EPR and NIR Oximetry for Diabetic FootMohammad Khan; Fiscal Year: 2007..If the promise of these techniques is fulfilled, clinicians will have a new powerful tool for management of peripheral vascular disease, based on fundamental pathophysiology. [unreadable] [unreadable] [unreadable]..
- Oxygen Guided Hypofractionated Radiotherapy for GliomasNadeem Khan; Fiscal Year: 2010....
- Oxidative Damage to DNA Repair PathwaysCameron Koch; Fiscal Year: 2006..Specific Aim 3 will investigate other aspects of DNA repair and DNA structural organization to determine their sensitivity to redox regulation. ..
- HYPOXIA AND GENE REPRESSIONAmato Giaccia; Fiscal Year: 2009..We will test these hypotheses through a combination of genetic and biochemical approaches in cell lines and in mice. ..
- CTGF in Pancreatic Tumor GrowthAmato J Giaccia; Fiscal Year: 2010..In summary, the proposed studies are intended to address an important mechanism by which CTGF affects tumor progression in pancreatic cancers and to determine how effective it is in combination therapy to bring it to the clinic. ..
- PET Imaging of Hypoxia with EF5Cameron Koch; Fiscal Year: 2009..In summary, the aims of this grant will extend and advance our overall laboratory interest in quantifying the degree and extent of clinically relevant hypoxia in the tumor microenvironment. ..
- Study of anti-angiogenesis enhanced radiotherapyRobert Griffin; Fiscal Year: 2008..The information to be obtained in this study will be a vital part of design and implementation of large animal and human clinical trials. ..
- Targeting Akt/NF-kappa beta for Pancreatic Cancer TherapyFazlul Sarkar; Fiscal Year: 2007..These results will provide mechanistic as well as pre-clinical data in support of our hypotheses and may open new and novel avenues for the treatment of human pancreatic cancer. ..
- A novel technology to generate conditionally inactivated alleles in miceGuo Hua Fong; Fiscal Year: 2008..This project aims at developing a novel technology that will significantly simplify this procedure and therefore accelerate biomedical research. [unreadable] [unreadable] [unreadable]..
- Combination fusion toxin and cytarabine therapy of AMLARTHUR FRANKEL; Fiscal Year: 2002..We anticipate these studies should provide the basis for the design and implementation of pivotal multi-institutional phase II and III trials of DTGM/cytarabine therapy for relapsed/refractory AML. ..
- REDOX MECHANISMS OF RESPIRATORY MUSCLE STRESS ADAPTATIONThomas Clanton; Fiscal Year: 2009..This basic science investigation will give new insights into fundamental skeletal muscle biology that will have applications to a variety of muscle disorders related to O2 transport limitation. ..
- 3 D HOLOGRAPHIC VIDEO RECORDING IN BIOLOGICAL TISSUEDavid Nolte; Fiscal Year: 2001....
- Lung Cell Genomic Threats from Physiological SignalsMark Gillespie; Fiscal Year: 2009..Such a finding could point to new pathways leading to somatic mutation and thus lead to a better understanding of cancer, aging, and other disorders wherein ROS are believed to play pathogenic roles. ..
- REACTIVE OXYGEN SPECIES AND VASCULAR O2 SENSINGMichael S Wolin; Fiscal Year: 2010..These studies should help define the origins of differences in physiological responses of pulmonary and coronary arteries to changes in O2 tension. ..
- PULMONARY VASODILATION AND GUANYLATE CYCLASE REGULATIONMichael S Wolin; Fiscal Year: 2010....
- Sertoli Cell Mediated Engulfment of Apoptotic Germ CellsKodi S Ravichandran; Fiscal Year: 2010..abstract_text> ..
- Predictive Markers of Glioblastoma Response to VEGF TrapJohn de Groot; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Mechanisms of ATP Release from RBC'sRandy Sprague; Fiscal Year: 2007..abstract_text> ..
- ROLE OF SURFACTANT PROTEIN B IN INNATE AIRWAY DEFENSEJOHN BAATZ; Fiscal Year: 2004..Results from the proposed experiments will lay the foundation for therapeutic use of SP-B for eradication of bacterial lung infections. ..
- Targeting of the Androgen Receptor in Prostate CancerJohn Isaacs; Fiscal Year: 2005..These peptide prodrugs will be designed so that they are substrates for the enzymatic activity of either Prostate Specific Antigen. ..
- Adult Forebrain Neural Stem Cell Response to IschemiaJack Parent; Fiscal Year: 2005..Progress in these Aims will advance our understanding of adult SVZ neurogenesis in the normal and ischemic brain, and may provide insight into the potential use of neural stem cells for stroke therapy. ..
- Diphtheria fusion protein therapy of AMLARTHUR FRANKEL; Fiscal Year: 2006..These studies should lead to the design of pivotal phase II clinical trials to determine the role of this therapeutic in AML management. ..
- Adenoviral vectors to target cellsPatricia Yotnda; Fiscal Year: 2006..At the conclusion of this study we will have in place an approach that could be implemented to allow truly targeted delivery of therapeutic vectors to disseminated malignancies. ..
- Is There a Link Between Alzheimer's and AtheroclerosisPaula Grammas; Fiscal Year: 2007..abstract_text> ..
- Free Fatty Acids and Hepatic Insulin ResistanceGuenther Boden; Fiscal Year: 2007..These studies will hopefully provide much needed information relative to important details and mechanisms of FFA induced hepatic insulin resistance. [unreadable] [unreadable]..
- SLS: Molecular Basis and Role in Invasive GAS DiseaseVictor Nizet; Fiscal Year: 2006..These hypotheses will be tested by molecular genetic studies, attempts protein purification and antibody development, and the use of targeted SLS mutants in in vitro assays of phagocytic function and our in vivo mouse model of GAS NF. ..
- OXYGEN SENSING AND REGULATION OF YEAST GENESROBERT POYTON; Fiscal Year: 2002..some other redox-sensitive oxygen binding protein involved in OCD gene expression? Aim 3: Does oxygen affect transcript turnover rate? Aim 4: What cis promoter sites mediate the OCD expression of COX6, COX5a, and CYC1? ..
- Function of FMRP in the Mouse Olfactory SystemJohn Larson; Fiscal Year: 2007..Such new information would be vital for evaluating novel treatment strategies for a class of developmental disabilities. [unreadable] [unreadable]..
- RENAL INJURY AND ADAPTATION TO HEME PROTEINSKarl Nath; Fiscal Year: 2001..Our proposed application thus continues to pursue the functionality of HO-1, as it utilized a new strategy, transgenic mice, and as it defines a new area of involvement namely, renal inflammation. ..
- OXYGEN SENSING AND SIGNAL TRANSDUCTIONH Bunn; Fiscal Year: 2003..abstract_text> ..
- The Role of NC2 in Gene Repression by Tumor HypoxiaNicholas Denko; Fiscal Year: 2007..These studies will determine if hypoxic gene repression through NC2 activity could be a potential therapeutic target for future molecular therapeutics in the treatment of human cancers. ..
- IGF-I and its binding proteins in vascular smooth muscle cellsCunming Duan; Fiscal Year: 2008..unreadable] [unreadable]..
- Sialic Acid O-Acetylation in GBS Pathogenesis & ImmunityVictor Nizet; Fiscal Year: 2010..Companion analyses will be performed on GBS isolates and human sera from recent prospective seroepidemiologic studies. ..
- IMMUNE RESPONSES IN LUNG ALLOGRAFT REJECTIONDavid Wilkes; Fiscal Year: 2006..Gene therapy will also be utilized to over express IDO in allograft donor lungs prior to transplantation followed by an assessment of the rejection response. ..
- MICROVASCULAR OCCLUSION IN ACUTE FOCAL CEREBRAL ISCHEMIAGregory Del Zoppo; Fiscal Year: 2004..These studies are a direct extension of completed work of this proposal, and are expected to add greatly to the understanding of how vascular ischemia affects neuron integrity with testable treatment strategies. ..
- SEX STEROID REGULATION OF IGF-I EXPRESSION IN BONEThomas McCarthy; Fiscal Year: 2003..Bone mass studies will be conducted using peripheral quantitative computer tomography, and will be correlated with basal and activated skeletal IGF-I expression. ..
- Hyperbaric Oxygenation May Increase Lung InjuryMichail Sitkovsky; Fiscal Year: 2007..unreadable]..
- Chemokine Signaling and Colitis in Gia2 Deficient MiceRobert Edwards; Fiscal Year: 2006..This application has the support of outstanding mentors at two institutions, and funding of this application will foster Dr Edwards' continued development as a physician-scientist. ..
- The Role of BCL-2 in Corneal Epithelial Cell SheddingDANIELLE ROBERTSON; Fiscal Year: 2008..4) That events leading to increased apoptosis such as UV light signal surface cell apoptosis through the phosphorylation of BCL-2. ..
- Fat Induced Insulin Resistance and AtherosclerosisGuenther Boden; Fiscal Year: 2007..We believe that these studies will provide important new information relative to the mechanism by which obesity and FFAs cause IR and ASVD in human subjects. ..
- RNAi Mediated Gene Disruption in Caenorhabditis ElegansWayne Van Voorhies; Fiscal Year: 2006..Such worms could identify candidate genes affecting processes that act "downstream" from the metabolic rate and provide valuable insights into the causes of aging and mechanisms by which it can be attenuated. ..
- Augmentation of Neurogenesis and Recovery After StrokeJack Parent; Fiscal Year: 2007..Progress in these aims will advance our understanding of mechanisms underlying neural stem cell regulation and rehabilitative plasticity after brain injury, and may lead to novel regenerative therapies for stroke. ..
- DNA modifications in primary pulmonary hypertensionMark Gillespie; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..