cell size

Summary

Summary: The quantity of volume or surface area of CELLS.

Top Publications

  1. ncbi A bacterial effector acts as a plant transcription factor and induces a cell size regulator
    Sabine Kay
    Institute of Biology, Department of Genetics, Martin Luther University Halle Wittenberg, Weinbergweg 10, D 06120 Halle Saale, Germany
    Science 318:648-51. 2007
  2. ncbi An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    W Brogiolo
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 11:213-21. 2001
  3. doi The regulation of cell size
    Alison C Lloyd
    MRC Laboratory for Molecular Cell Biology and the UCL Cancer Institute, University College London, Gower Street, London WC1E 6BT, UK Electronic address
    Cell 154:1194-205. 2013
  4. ncbi The effects of molecular noise and size control on variability in the budding yeast cell cycle
    Stefano Di Talia
    The Rockefeller University, New York, New York 10021, USA
    Nature 448:947-51. 2007
  5. doi Dicoumarol activates Ca2+-permeable cation channels triggering erythrocyte cell membrane scrambling
    Syed M Qadri
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 28:857-64. 2011
  6. doi The NFĸB pathway inhibitors Bay 11-7082 and parthenolide induce programmed cell death in anucleated Erythrocytes
    Mehrdad Ghashghaeinia
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 27:45-54. 2011
  7. pmc Cell growth and size homeostasis in proliferating animal cells
    Amit Tzur
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 325:167-71. 2009
  8. ncbi Functional profiling of the Saccharomyces cerevisiae genome
    Guri Giaever
    Stanford Genome Technology Center, Stanford University, Palo Alto, California 94304, USA
    Nature 418:387-91. 2002
  9. ncbi Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance
    Laurent Yvan-Charvet
    Unit 465, Institut National de la Sante et de la Recherche Medicale INSERM, Paris, France
    Diabetes 54:991-9. 2005
  10. ncbi Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5
    Robertus A M de Bruin
    Department of Molecular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Cell 117:887-98. 2004

Detail Information

Publications370 found, 100 shown here

  1. ncbi A bacterial effector acts as a plant transcription factor and induces a cell size regulator
    Sabine Kay
    Institute of Biology, Department of Genetics, Martin Luther University Halle Wittenberg, Weinbergweg 10, D 06120 Halle Saale, Germany
    Science 318:648-51. 2007
    ..We show that AvrBs3 induces the expression of a master regulator of cell size, upa20, which encodes a transcription factor containing a basic helix-loop-helix domain...
  2. ncbi An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    W Brogiolo
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 11:213-21. 2001
    ..is fundamental in developing multicellular organisms and occurs through the control of cell number and cell size. Studies in Drosophila have identified an evolutionarily conserved signaling pathway that regulates organismal ..
  3. doi The regulation of cell size
    Alison C Lloyd
    MRC Laboratory for Molecular Cell Biology and the UCL Cancer Institute, University College London, Gower Street, London WC1E 6BT, UK Electronic address
    Cell 154:1194-205. 2013
    An adult animal consists of cells of vastly different size and activity, but the regulation of cell size remains poorly understood...
  4. ncbi The effects of molecular noise and size control on variability in the budding yeast cell cycle
    Stefano Di Talia
    The Rockefeller University, New York, New York 10021, USA
    Nature 448:947-51. 2007
    ..b>Cell size control contributes significantly to G1 variability in daughter cells but not in mother cells...
  5. doi Dicoumarol activates Ca2+-permeable cation channels triggering erythrocyte cell membrane scrambling
    Syed M Qadri
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 28:857-64. 2011
    ..In conclusion, dicoumarol stimulates suicidal death of erythrocytes by stimulating Ca(2+) entry and subsequent triggering of Ca(2+) dependent cell membrane scrambling...
  6. doi The NFĸB pathway inhibitors Bay 11-7082 and parthenolide induce programmed cell death in anucleated Erythrocytes
    Mehrdad Ghashghaeinia
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 27:45-54. 2011
    ..In conclusion, the pharmacological inhibitors of NFκB, Bay 11-7082 and parthenolide, interfere with the survival of erythrocytes involving mechanisms other than disruption of NFκB-dependent gene expression...
  7. pmc Cell growth and size homeostasis in proliferating animal cells
    Amit Tzur
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 325:167-71. 2009
    ..We examined cell size distributions in populations of lymphoblasts and applied a mathematical analysis to calculate how growth rates ..
  8. ncbi Functional profiling of the Saccharomyces cerevisiae genome
    Guri Giaever
    Stanford Genome Technology Center, Stanford University, Palo Alto, California 94304, USA
    Nature 418:387-91. 2002
    ..Our results validate the yeast gene-deletion collection as a valuable resource for functional genomics...
  9. ncbi Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance
    Laurent Yvan-Charvet
    Unit 465, Institut National de la Sante et de la Recherche Medicale INSERM, Paris, France
    Diabetes 54:991-9. 2005
    ..These data support the idea that AT2R-dependent Ang II signaling increases adipose cell mass and glucose intolerance and thus could participate to the deleterious effects of a high-fat diet...
  10. ncbi Cln3 activates G1-specific transcription via phosphorylation of the SBF bound repressor Whi5
    Robertus A M de Bruin
    Department of Molecular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Cell 117:887-98. 2004
    ..Like mammalian Rb, Whi5 is a G1-specific transcriptional repressor antagonized by CDK...
  11. ncbi How cells coordinate growth and division
    Paul Jorgensen
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto ON, Canada M5S 1A8
    Curr Biol 14:R1014-27. 2004
    ..Despite a long history of study, the fascinating mechanisms that control cell size have resisted molecular genetic insight...
  12. pmc Cell size control in yeast
    Jonathan J Turner
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Curr Biol 22:R350-9. 2012
    b>Cell size is an important adaptive trait that influences nearly all aspects of cellular physiology...
  13. pmc Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
    Samy Lamouille
    Department of Cell and Tissue Biology, Program in Cell Biology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 178:437-51. 2007
    ..We observe that TGF-beta induces increased cell size and protein content during EMT...
  14. pmc Isolation by size of epithelial tumor cells : a new method for the immunomorphological and molecular characterization of circulatingtumor cells
    G Vona
    INSERM U 370, Faculte Necker, Paris, France
    Am J Pathol 156:57-63. 2000
    ..Overall, ISET constitutes a novel approach that should open new perpectives in molecular medicine...
  15. doi Dynamics of fat cell turnover in humans
    Kirsty L Spalding
    Department of Cell and Molecular Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Nature 453:783-7. 2008
    ..The high turnover of adipocytes establishes a new therapeutic target for pharmacological intervention in obesity...
  16. ncbi Rho GTPases in cell biology
    Sandrine Etienne-Manneville
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, Cancer Research UK Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Nature 420:629-35. 2002
    ..With spatial and temporal activation of multiple switches factored in, it is not surprising to find Rho GTPases having such a prominent role in eukaryotic cell biology...
  17. doi p38 MAPK activation and function following osmotic shock of erythrocytes
    Sergios Gatidis
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 28:1279-86. 2011
    ..In conclusion, p38 kinase is expressed in erythrocytes and participates in the machinery triggering eryptosis following hyperosmotic shock...
  18. ncbi Static magnetic fields affect cell size, shape, orientation, and membrane surface of human glioblastoma cells, as demonstrated by electron, optic, and atomic force microscopy
    Laura Teodori
    Unità di Biotecnologie, Sezione di Tossicologia e Scienze Biomediche, ENEA Centro Ricerche Casaccia, Via Anguillarese 301, 00060 Rome, Italy
    Cytometry A 69:75-85. 2006
    ..To investigate the effect of exposure to increasing doses of SMF on cell morphology, human glioblastoma cells were exposed to SMF ranging between 80 and 3,000 G (8 and 300 mT)...
  19. ncbi CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast
    Michael Costanzo
    Department of Medical Genetics and Microbiology, University of Toronto, 1 King s College Circle, Toronto, M5S 1A8, Canada
    Cell 117:899-913. 2004
    ..However, in yeast, an analogous G1 phase target of CDK activity has remained elusive. Here we show that the cell size regulator Whi5 inhibits G1/S transcription and that this inhibition is relieved by CDK-mediated phosphorylation...
  20. ncbi c-Myc regulates mammalian body size by controlling cell number but not cell size
    A Trumpp
    Swiss Institute for Experimental Cancer Research ISREC, Ch des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 414:768-73. 2001
    ..We propose that in mammals c-Myc controls the decision to divide or not to divide and thereby functions as a crucial mediator of signals that determine organ and body size...
  21. pmc Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size
    Yanyun Gu
    Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Diabetes 60:827-37. 2011
    ..We examined the role of Rictor/mammalian target of rapamycin complex 2 (mTORC2), a key component of the phosphotidylinositol-3-kinase (PI3K)/mTORC2/AKT signaling pathway, in regulating both β-cell mass and function...
  22. ncbi Rapid morphological changes in astrocytes are accompanied by redistribution but not by quantitative changes of cytoskeletal proteins
    S Safavi-Abbasi
    Department of Anatomy and Developmental Neurobiology, , , Germany
    Glia 36:102-15. 2001
    ..These experiments demonstrate that the recently described RhoA-mediated signaling cascade between the cell surface and cytoskeletal proteins is only one of several signaling pathways acting on the astrocytic cytoskeleton...
  23. ncbi Drosophila myc regulates cellular growth during development
    L A Johnston
    Fred Hutchinson Cancer Research Center, Division of Basic Sciences, Seattle, Washington 98109, USA
    Cell 98:779-90. 1999
    ..in the fly wing, we show that loss of dMyc retards cellular growth (accumulation of cell mass) and reduces cell size, whereas dMyc overproduction increases growth rates and cell size...
  24. pmc Adipocyte turnover: relevance to human adipose tissue morphology
    Erik Arner
    Department of Medicine, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden
    Diabetes 59:105-9. 2010
    ..Adipose tissue may contain few large adipocytes (hypertrophy) or many small adipocytes (hyperplasia). We investigated factors of putative importance for adipose tissue morphology...
  25. pmc Primary cilia regulate mTORC1 activity and cell size through Lkb1
    Christopher Boehlke
    Renal Unit, Department of Medicine, University Medical Center, Albert Ludwig University of Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    Nat Cell Biol 12:1115-22. 2010
    The mTOR pathway is the central regulator of cell size. External signals from growth factors and nutrients converge on the mTORC1 multi-protein complex to modulate downstream targets, but how the different inputs are integrated and ..
  26. doi Protein kinase CK1α regulates erythrocyte survival
    Christine Zelenak
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 29:171-80. 2012
    ..In conclusion, CK1 isoform α participates in the regulation of erythrocyte programmed cell death by modulating cytosolic Ca(2+) activity...
  27. doi Sunitinib-sensitive suicidal erythrocyte death
    Nazneen Shaik
    Department of Physiology, University of Tuebingen, Tuebingen, Germany
    Cell Physiol Biochem 30:512-22. 2012
    ..Sunitinib, however, did not significantly modify cytosolic ATP and ceramide abundance. The present observations reveal that sunitinib is able to trigger suicidal death in erythrocytes even in the absence of nuclei and mitochondria...
  28. ncbi A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size
    Markus Welcker
    Divisions of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Curr Biol 14:1852-7. 2004
    ..Moreover, we find that knockdown of Fbw7 increases cell size consistent with its ability to control c-Myc levels in the nucleolus...
  29. ncbi The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation
    K Barrett
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown 02129, USA
    Cell 91:905-15. 1997
    ..Together, these results establish a Rho-mediated signaling pathway that is essential for the major morphogenetic events in Drosophila gastrulation...
  30. doi Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding
    Martin P Stewart
    ETH Zurich, Department of Biosystems Science and Engineering, CH 4058 Basel, Switzerland
    Nature 469:226-30. 2011
    ..Thus, by locally modulating actomyosin-cortex-dependent surface tension and globally regulating osmotic pressure, cells can control their volume, shape and mechanical properties...
  31. pmc A moonlighting enzyme links Escherichia coli cell size with central metabolism
    Norbert S Hill
    Department of Biology, Washington University, Saint Louis, Missouri, United States of America
    PLoS Genet 9:e1003663. 2013
    ..Here we report the identification of the glucosyltransferase OpgH as a nutrient-dependent regulator of E. coli cell size. During growth under nutrient-rich conditions, OpgH localizes to the nascent septal site, where it antagonizes ..
  32. pmc The size of the nucleus increases as yeast cells grow
    Paul Jorgensen
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, ON M5S 1A8, Canada
    Mol Biol Cell 18:3523-32. 2007
    ..At the single cell level, nuclear and cell size were strongly correlated in growing wild-type cells, as determined by three different microscopic approaches...
  33. doi Beauvericin induced erythrocyte cell membrane scrambling
    Syed M Qadri
    Department of Physiology, University of Tubingen, Gmelinstr 5, 72076 Tubingen, Germany
    Toxicology 283:24-31. 2011
    ..The present observations disclose novel effects of beauvericin, i.e. stimulation of Ca²+ entry with subsequent cell membrane scrambling and inhibition of Ca²+ activated K+ channels with blunting of cell shrinkage...
  34. pmc RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity
    W T Arthur
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Biol Cell 12:2711-20. 2001
    ..Taken together, these data demonstrate that integrin-triggered RhoA inhibition by p190RhoGAP enhances spreading and migration by regulating cell protrusion and polarity...
  35. ncbi Enhanced programmed cell death of iron-deficient erythrocytes
    Daniela S Kempe
    Department of Physiology, University of Tubingen, Tubingen, Germany
    FASEB J 20:368-70. 2006
    ..In this study, phosphatidylserine exposure, cell size, and cytosolic Ca2+ were measured by FACS analysis of annexin-V binding, forward scatter, and Fluo-3 ..
  36. ncbi Antagonistic control of muscle cell size by AMPK and mTORC1
    Remi Mounier
    Inserm U1016, Centre National de la Recherche Scientifique CNRS, UMR8104, University Paris Descartes, Institut Cochin, Paris, France
    Cell Cycle 10:2640-6. 2011
    ..Conversely, muscle cells lacking AMPK have increased mTORC1 activation with increased cell size and protein synthesis rate...
  37. doi Quantification of astrocyte volume changes during ischemia in situ reveals two populations of astrocytes in the cortex of GFAP/EGFP mice
    Jana Benesova
    Laboratory of Neurobiology, Department of Cellular Neurophysiology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    J Neurosci Res 87:96-111. 2009
    ..8). Immunohistochemical analysis suggests that the diverse expression of Kir4.1 channels and GFAP as well as differences in the accumulation of taurine might contribute to the distinct ability of astrocytes to regulate their volume...
  38. doi Effect of casein kinase 1α activator pyrvinium pamoate on erythrocyte ion channels
    Yuliya Kucherenko
    Department of Physiology, University of Tubingen, Gmelinstrasse 5, Tubingen, Germany
    Cell Physiol Biochem 30:407-17. 2012
    ....
  39. doi Janus kinase 3 is expressed in erythrocytes, phosphorylated upon energy depletion and involved in the regulation of suicidal erythrocyte death
    Shefalee K Bhavsar
    Department of Physiology, University of Tubingen, Gmelinstrasse 5, Tubingen, Germany
    Cell Physiol Biochem 27:547-56. 2011
    ..The observations disclose a completely novel role of Janus kinase 3, i.e. the triggering of cell membrane scrambling in energy depleted erythrocytes...
  40. doi Physiology of cell volume regulation in vertebrates
    Else K Hoffmann
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Physiol Rev 89:193-277. 2009
    ..A discussion of this issue concludes the review...
  41. doi Dynamic adhesion of eryptotic erythrocytes to endothelial cells via CXCL16/SR-PSOX
    Oliver Borst
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Am J Physiol Cell Physiol 302:C644-51. 2012
    ..The present observations demonstrate that eryptotic erythrocytes adhere to endothelial cells of the vascular wall in part by interaction of phosphatidylserine exposed at the erythrocyte surface with endothelial CXCL16...
  42. doi Hemotrophic mycoplasmas induce programmed cell death in red blood cells
    Kathrin M Felder
    Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland
    Cell Physiol Biochem 27:557-64. 2011
    ..suis is able to induce eryptotic processes it is concluded that eryptosis is one anemia-inducing factor during M. suis infections and, therefore, plays a significant role in the pathogenesis of infectious anemia due to HM infection...
  43. pmc Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
    D C Goberdhan
    Research School of Biosciences, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom
    Genes Dev 13:3244-58. 1999
    ..evolutionarily conserved Drosophila PTEN homolog, DPTEN, suppresses hyperplastic growth in flies by reducing cell size and number...
  44. pmc c-di-AMP is a new second messenger in Staphylococcus aureus with a role in controlling cell size and envelope stress
    Rebecca M Corrigan
    Section of Microbiology, Imperial College London, London, United Kingdom
    PLoS Pathog 7:e1002217. 2011
    ..Lastly, microscopic analysis of wild-type and gdpP mutant strains revealed a 13-22% reduction in the cell size of bacteria with increased c-di-AMP levels...
  45. ncbi Generation of cell lines with tetracycline-regulated autophagy and a role for autophagy in controlling cell size
    Nao Hosokawa
    Department of Bioregulation and Metabolism, Tokyo Metropolitan Institute of Medical Science, 3 18 22 Honkomagome, Tokyo 113 8613, Japan
    FEBS Lett 580:2623-9. 2006
    ..We applied this novel system to examine the contribution of autophagy to controlling cell size. Cell size reduction in response to starvation was significantly inhibited in cells unable to undergo autophagy...
  46. ncbi Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
    Michael A Crackower
    IMBA, Institute for Molecular Biotechnology of the Austrian Academy of Sciences, c o Dr Bohr Gasse 7, A 1030, Vienna, Austria
    Cell 110:737-49. 2002
    ..PI3Kalpha mediates the alteration in cell size while PI3Kgamma acts as a negative regulator of cardiac contractility...
  47. ncbi Enhanced susceptibility to erythrocyte "apoptosis" following phosphate depletion
    Christina Birka
    Physiologisches Institut der Universitat Tubingen, Gmelinstrasse 5, 72076 Tubingen, Germany
    Pflugers Arch 448:471-7. 2004
    ..In the present experiments, phosphatidylserine exposure and cell size were measured by fluorescence-activated cell sorting (FACS) analysis of annexin binding and forward scatter, ..
  48. ncbi Regulation of cell movement is mediated by stretch-activated calcium channels
    J Lee
    Department of Cell Biology and Anatomy, University of North Carolina, Chapel Hill 27599 7090, USA
    Nature 400:382-6. 1999
    ..Thus, we have defined a mechanism by which cells can detect and transduce mechanical forces into biochemical signals that can modulate locomotion...
  49. doi Polyphyllin D induces apoptosis in human erythrocytes through Ca²⁺ rise and membrane permeabilization
    Minghui Gao
    Programme of Biochemistry, School of Life Sciences, The Chinese University of Hong Kong, Room 514, Basic Medical Sciences Building, Shatin, NT, Hong Kong, China
    Arch Toxicol 86:741-52. 2012
    ..Taken together, we report here for the first time the toxicity of PD in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis...
  50. doi Carbon monoxide-sensitive apoptotic death of erythrocytes
    Elisabeth Lang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Basic Clin Pharmacol Toxicol 111:348-55. 2012
    ..In conclusion, CORM-2 stimulates cell membrane scrambling of erythrocytes, an effect largely due to Ca²⁺ entry and partially reversed by O₂...
  51. doi Enhanced erythrocyte membrane exposure of phosphatidylserine following sorafenib treatment: an in vivo and in vitro study
    Adrian Lupescu
    Department of Physiology, Tuebingen, Tubingen, Germany
    Cell Physiol Biochem 30:876-88. 2012
    ..Signaling leading to eryptosis include increase in cytosolic Ca(2+)activity ([Ca(2+)](i)), formation of ceramide, ATP-depletion and oxidative stress. The present study explored, whether sorafenib triggers eryptosis in vitro and in vivo...
  52. doi Tanshinone IIA stimulates erythrocyte phosphatidylserine exposure
    Christine Zelenak
    Department of Physiology, University of Tuebingen, Tuebingen, Germany
    Cell Physiol Biochem 30:282-94. 2012
    ..e. triggering of Ca(2+) entry, ATP depletion and ceramide formation in erythrocytes, events eventually leading to eryptosis with cell shrinkage and cell membrane scrambling...
  53. pmc Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth
    Junghyo Jo
    Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethedsa, Maryland, USA
    PLoS Comput Biol 5:e1000324. 2009
    Adipose tissue grows by two mechanisms: hyperplasia (cell number increase) and hypertrophy (cell size increase). Genetics and diet affect the relative contributions of these two mechanisms to the growth of adipose tissue in obesity...
  54. doi Inhibition of Ca(2+) entry and suicidal erythrocyte death by naringin
    Nazneen Shaik
    Department of Physiology, University of Tuebingen, Tuebingen, Germany
    Cell Physiol Biochem 30:678-86. 2012
    ..In conclusion, naringin blunts the increase of cytosolic Ca(2+) concentration, the shrinkage, the cell membrane scrambling and thus the suicidal death of erythrocytes following energy depletion or oxidative stress...
  55. doi Regulation of erythrocyte survival by AMP-activated protein kinase
    Michael Foller
    Department of Physiology, University of Tubingen, Tubingen, Germany
    FASEB J 23:1072-80. 2009
    ..The observations disclose a critical role of AMPK in the survival of circulating erythrocytes...
  56. ncbi Participation of leukotriene C(4) in the regulation of suicidal erythrocyte death
    M Foller
    Department of Physiology, University of Tubingen, Germany
    J Physiol Pharmacol 60:135-43. 2009
    ..Cysteinyl-leukotrienes thus participate in the signaling of eryptosis during energy depletion...
  57. ncbi Integrin signaling
    F G Giancotti
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 285:1028-32. 1999
    ..Many integrin signals converge on cell cycle regulation, directing cells to live or die, to proliferate, or to exit the cell cycle and differentiate...
  58. doi Sphingomyelinase-induced adhesion of eryptotic erythrocytes to endothelial cells
    Majed Abed
    Physiologisches Institut, Eberhard Karls Universitat Tubingen, Gmelinstr 5, D 72076 Tubingen, Germany
    Am J Physiol Cell Physiol 303:C991-9. 2012
    ..Thus exposure to sphingomyelinase or C6-ceramide triggers eryptosis followed by phosphatidylserine- and CXCL16-sensitive adhesion of eryptotic erythrocytes to HUVEC...
  59. doi Gossypol-induced suicidal erythrocyte death
    Mohanad Zbidah
    Department of Physiology, University of Tuebingen, Gmelinstrasse 5, 72076 Tuebingen, Germany
    Toxicology 302:101-5. 2012
    ..The present observations reveal a novel effect of gossypol on human erythrocytes, which contributes to or even accounts for the triggering of anemia by this substance...
  60. doi Overexpression of PhEXPA1 increases cell size, modifies cell wall polymer composition and affects the timing of axillary meristem development in Petunia hybrida
    Sara Zenoni
    Department of Biotechnology, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy
    New Phytol 191:662-77. 2011
    ..These results support a role for expansins in the determination of organ shape, in lateral branching, and in the variation of cell wall polymer composition, probably reflecting a complex role in cell wall metabolism...
  61. pmc WNK3 modulates transport of Cl- in and out of cells: implications for control of cell volume and neuronal excitability
    Kristopher T Kahle
    Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 102:16783-8. 2005
    ..They suggest that WNK3 is part of the Cl(-)/volume-sensing mechanism necessary for the maintenance of cell volume during osmotic stress and the dynamic modulation of GABA neurotransmission...
  62. ncbi SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells
    Eric Delpire
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Biochem J 409:321-31. 2008
    ..Finally, as our understanding is a work in progress, we also identify unresolved questions and controversies that warrant further investigation...
  63. pmc A link between mitotic entry and membrane growth suggests a novel model for cell size control
    Steph D Anastasia
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    J Cell Biol 197:89-104. 2012
    ..Growth-dependent signaling could explain how membrane growth is integrated with cell cycle progression. It could also control both cell size and morphogenesis, thereby reconciling divergent models for mitotic checkpoint function.
  64. doi Ectopic expression of human mTOR increases viability, robustness, cell size, proliferation, and antibody production of chinese hamster ovary cells
    Imke A J Dreesen
    Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH 4058 Basel, Switzerland
    Biotechnol Bioeng 108:853-66. 2011
    ..characteristics of Chinese hamster ovary (CHO) cell-derived production cell lines such as cell growth (increased cell size and protein content), proliferation (increased cell-cycle progression), viability (decreased apoptosis), ..
  65. doi Mechanisms of intracellular scaling
    Daniel L Levy
    Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
    Annu Rev Cell Dev Biol 28:113-35. 2012
    b>Cell size varies widely among different organisms as well as within the same organism in different tissue types and during development, which places variable metabolic and functional demands on organelles and internal structures...
  66. pmc Myosin concentration underlies cell size-dependent scalability of actomyosin ring constriction
    Meredith E K Calvert
    Temasek Life Sciences Laboratory, The National University of Singapore, Singapore 117604
    J Cell Biol 195:799-813. 2011
    ..Because the mechanical characteristics of contractile rings are conserved, we predict that these findings will be relevant to actomyosin ring constriction in other cell types...
  67. pmc Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production
    Shuling Zhang
    Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute NIH, Bethesda, MD 20892, USA
    Blood 117:1228-38. 2011
    ..Homozygous knock-in mice exhibited reductions in body, organ, and cell size. Although reductions in most organ sizes were proportional to decreased body weight, spleens were ..
  68. pmc Cell size of alveolar macrophages: an interspecies comparison
    F Krombach
    Institute for Surgical Research, University of Munich, Germany
    Environ Health Perspect 105:1261-3. 1997
    ..The purpose of this study was to compare the cell size of rat, hamster, monkey, and human AM by selective flow cytometric analysis of cell volume...
  69. pmc An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes
    Valentina Benfenati
    Institute for Nanostructured Materials, Consiglio Nazionale delle Ricerche, 40129 Bologna, Italy
    Proc Natl Acad Sci U S A 108:2563-8. 2011
    ..Our data indicate that astrocytes contain a TRPV4/AQP4 complex that constitutes a key element in the brain's volume homeostasis by acting as an osmosensor that couples osmotic stress to downstream signaling cascades...
  70. doi MicroRNAs are dynamically regulated in hypertrophic hearts, and miR-199a is essential for the maintenance of cell size in cardiomyocytes
    Xiao Wei Song
    Department of Cardiology, Changhai Hospital, Shanghai, China
    J Cell Physiol 225:437-43. 2010
    Cardiac hypertrophy, which is characterized by an increase in cell size and reactivation of fetal genes, occurs as an adaptive response to diverse forms of stress and often results in heart failure and sudden death...
  71. pmc Anemia and splenomegaly in cGKI-deficient mice
    Michael Foller
    Department of Physiology, Interfakultäres Institut für Biochemie, University of Tubingen, D72076 Tübingen, Germany
    Proc Natl Acad Sci U S A 105:6771-6. 2008
    ..Together, these results identify a role of cGKI as mediator of erythrocyte survival and extend the emerging concept that cGMP/cGKI signaling has an antiapoptotic/prosurvival function in a number of cell types in vivo...
  72. doi Exit from proliferation during leaf development in Arabidopsis thaliana: a not-so-gradual process
    Megan Andriankaja
    Department of Plant Systems Biology, VIB, 9052 Gent, Belgium
    Dev Cell 22:64-78. 2012
    ..Hence, differentiation of the photosynthetic machinery is important for regulating the exit from proliferation...
  73. pmc The conserved phosphoinositide 3-kinase pathway determines heart size in mice
    T Shioi
    Cardiovascular Division, Beth Israel Deaconess Medical Center and Departments of Medicine and Cell Biology, Harvard Medical School, Boston, MA 02215, USA
    EMBO J 19:2537-48. 2000
    ..Thus, the PI3K pathway is necessary and sufficient to promote organ growth in mammals...
  74. ncbi A conserved RING finger protein required for histone H2B monoubiquitination and cell size control
    William W Hwang
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Cell 11:261-6. 2003
    ..RING domain of Bre1 is essential for both of these modifications as is Lge1 (Large 1), a protein required for cell size control that copurifies with Bre1. In cells lacking the euchromatin-associated histone variant H2A...
  75. ncbi Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells
    Kathrin Renner
    Tyrolean Cancer Research Institute, Innrain 66, A 6020 Innsbruck, Austria
    Biochim Biophys Acta 1642:115-23. 2003
    ..These changes correlated with alterations in cell size, cytosolic, and mitochondrial marker enzymes...
  76. doi Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply
    Gilles A Spoden
    Department of Cell Metabolism and Differentiation, Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria
    Exp Cell Res 315:2765-74. 2009
    ..significant decrease of the population doubling (PDL rate) and cell proliferation rate as well as an increase in cell size, whereas under glucose restriction an increase in PDL and cell proliferation rates but a decrease in cell size ..
  77. doi Ribosomal protein S6 kinase from TOP mRNAs to cell size
    Oded Meyuhas
    Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel
    Prog Mol Biol Transl Sci 90:109-53. 2009
    ..Instead, S6K is primarily involved in regulation of cell size, and affects glucose homeostasis, but is dispensable for global protein synthesis, whereas translational ..
  78. doi In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    Qiao Zhou
    Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 455:627-32. 2008
    ..This study provides an example of cellular reprogramming using defined factors in an adult organ and suggests a general paradigm for directing cell reprogramming without reversion to a pluripotent stem cell state...
  79. pmc Cell size and the initiation of DNA replication in bacteria
    Norbert S Hill
    Department of Biology, Washington University in St Louis, St Louis, Missouri, United States of America
    PLoS Genet 8:e1002549. 2012
    ..subtilis mutants that are ~30% smaller than wild-type cells, indicating that achievement of a particular cell size is not obligatory for initiation...
  80. doi An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume
    Osman Yuksel
    Department of Gastroenterology, Dişkapi Yildirim Beyazit Hospital, Ankara, Turkey
    Platelets 20:277-81. 2009
    ..005). In UC, MPV did not correlate with ESR, CRP and white blood cell. Our study showed that MPV reduced in UC, particularly in patients with active UC. Decreased MPV may be an indicator for increased disease activity in patients with UC...
  81. doi Stimulation of suicidal erythrocyte death by α-lipoic acid
    Shefalee K Bhavsar
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Cell Physiol Biochem 26:859-68. 2010
    ..In conclusion, α-lipoic acid triggers eryptosis but by the same token counteracts eryptosis during oxidative stress. α-lipoic acid sensitive eryptosis may lead to anemia and derangements of microcirculation...
  82. doi Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation
    Michael Andäng
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden
    Nature 451:460-4. 2008
    ..These results indicate the presence of a fundamentally different mechanism of proliferation control in these stem cells, in comparison with most somatic cells, involving proteins in the DNA damage checkpoint pathway...
  83. doi Coordinating genome expression with cell size
    Samuel Marguerat
    University College London, Department of Genetics, Evolution and Environment, London, WC1E 6BT, UK
    Trends Genet 28:560-5. 2012
    b>Cell size is highly variable; cells from various tissues differ in volume over orders of magnitudes, from tiny lymphocytes to giant neurons, and cells of a given type change size during the cell cycle...
  84. pmc Cytoplasmic volume modulates spindle size during embryogenesis
    Matthew C Good
    Department of Molecular and Cellular Biology, University of California Berkeley, Berkeley, CA 94720, USA
    Science 342:856-60. 2013
    ..whether spindle size regulation is achieved through a developmental program or is intrinsically specified by cell size or shape, we developed a system to encapsulate cytoplasm from Xenopus eggs and embryos inside cell-like ..
  85. ncbi Evidence for a three-way trade-off between nitrogen and phosphorus competitive abilities and cell size in phytoplankton
    Kyle F Edwards
    Kellogg Biological Station, Michigan State University, Hickory Corners, Michigan 49060, USA
    Ecology 92:2085-95. 2011
    ..Here we demonstrate a three-way trade-off between cell size and competitive abilities for nitrogen and phosphorus in marine and freshwater phytoplankton...
  86. pmc Changes in cytoplasmic volume are sufficient to drive spindle scaling
    James Hazel
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
    Science 342:853-6. 2013
    ..The mechanism responsible for this scaling is unclear, because uncoupling cell size from a developmental or cellular context has proven experimentally challenging...
  87. pmc Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis
    Carl Owen
    Integrative Physiology, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 7:e32700. 2012
    ..Moreover, PTP1B does not appear to be the major negative regulator of the IR in adipocytes...
  88. ncbi Mean platelet volume in patients with type 2 diabetes mellitus
    N Papanas
    Second Department of Internal Medicine, Democritus University of Thrace, Greece
    Platelets 15:475-8. 2004
    ..To evaluate mean platelet volume (MPV) in type 2 diabetic versus non-diabetic patients, as well as to investigate the associations between MPV and diabetic complications...
  89. pmc Distinct expression/function of potassium and chloride channels contributes to the diverse volume regulation in cortical astrocytes of GFAP/EGFP mice
    Jana Benesova
    Department of Cellular Neurophysiology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    PLoS ONE 7:e29725. 2012
    ..Thus, we propose that the diverse volume changes displayed by cortical astrocytes during OGD mainly result from their distinct expression patterns of ClC2 and K(2P) channels...
  90. pmc The role of the membrane potential in chondrocyte volume regulation
    Rebecca Lewis
    Department of Musculoskeletal Biology, Institute of Aging and Chronic Disease, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK
    J Cell Physiol 226:2979-86. 2011
    ..The positive RMP may be a protective adaptation that allows chondrocytes to respond to the dramatic osmotic changes, with minimal changes in cell volume...
  91. ncbi Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase
    Guenter Haemmerle
    Institute of Molecular Biosciences, University of Graz, Austria
    Science 312:734-7. 2006
    ..These results indicate that ATGL is rate limiting in the catabolism of cellular fat depots and plays an important role in energy homeostasis...
  92. doi Osmotic swelling characteristics of glial cells in the murine hippocampus, cerebellum, and retina in situ
    Petra G Hirrlinger
    Paul Flechsig Institute of Brain Research, University of Leipzig, Faculty of Medicine, Leipzig, Germany
    J Neurochem 105:1405-17. 2008
    ..The data suggest that Kir channels are differently implicated in cell volume homeostasis of retinal Müller cells and brain astrocytes and that Müller cells and brain astrocytes differ in their osmotic swelling properties...
  93. pmc The ANGUSTIFOLIA gene of Arabidopsis, a plant CtBP gene, regulates leaf-cell expansion, the arrangement of cortical microtubules in leaf cells and expression of a gene involved in cell-wall formation
    Gyung Tae Kim
    National Institute for Basic Biology Center for Integrative Bioscience, 38 Nishigounaka, Myodaiji cho, Okazaki 444 8585, Japan
    EMBO J 21:1267-79. 2002
    ..g. the gene involved in formation of cell walls, MERI5. A discussion of the molecular mechanisms involved in the leaf shape regulation is presented based on our observations...
  94. pmc Regulation of bradykinin-induced activation of volume-sensitive outwardly rectifying anion channels by Ca2+ nanodomains in mouse astrocytes
    Tenpei Akita
    Department of Cell Physiology, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Okazaki 444 8585, Japan
    J Physiol 589:3909-27. 2011
    ....
  95. pmc An improved protocol for optical projection tomography imaging reveals lobular heterogeneities in pancreatic islet and β-cell mass distribution
    Andreas Hörnblad
    Umeå Centre for Molecular Medicine, Umea University, Umea, Sweden
    Islets 3:204-8. 2011
    ..Altogether, our data show that CLAHE substantially improves OPT based assessments of the islets of Langerhans and that lobular origin must be taken into careful consideration in quantitative and spatial assessments of the pancreas...
  96. doi Cell morphology and intracellular ionic homeostasis explored with a multimodal approach combining epifluorescence and digital holographic microscopy
    Nicolas Pavillon
    Advanced Photonics Laboratory MVD, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    J Biophotonics 3:432-6. 2010
    ..This is demonstrated by the study of intracellular calcium homeostasis associated with the change in cell volume, which play a critical role in the excitotoxicity-induced neuronal death...
  97. doi Morphologically distinct classes of relay cells exhibit regional preferences in the dorsal lateral geniculate nucleus of the mouse
    Thomas E Krahe
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Center, Richmond, Virginia 23298, USA
    J Neurosci 31:17437-48. 2011
    ..Overall, these data coupled with recent observations in the retina suggest that the mouse has many of the hallmark features of a system-wide parallel organization...
  98. pmc Cell size is positively correlated between different tissues in passerine birds and amphibians, but not necessarily in mammals
    J Kozlowski
    Jagiellonian University, Institute of Environmental Sciences, Krakow, Poland
    Biol Lett 6:792-6. 2010
    We examined cell size correlations between tissues, and cell size to body mass relationships in passerine birds, amphibians and mammals...
  99. ncbi Type 2 diabetes-a matter of beta-cell life and death?
    Christopher J Rhodes
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Science 307:380-4. 2005
    ..Thus, the IRS-2 pathway appears to be a crucial participant in the tenuous balance between effective pancreatic beta-cell mass and insulin resistance...
  100. ncbi Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea
    Kun Ho Yoon
    Department of Endocrinology and Metabolism, Immunology, and Cell Biology Core Laboratory, Institutes of Medical Science, The Catholic University of Korea, Seoul, Korea 137 701
    J Clin Endocrinol Metab 88:2300-8. 2003
    ..Moreover, decreased beta-cell but increased alpha-cell proportion in the islets suggests for a selective beta-cell loss in the pathogenesis of Korean type 2 diabetes...
  101. doi A multi-instrumental approach to identify and purify very small embryonic like stem cells (VSELs) from adult tissues
    Mariusz Z Ratajczak
    University of Louisville, 500 South Floyd Street, Louisville, KY 40202, USA
    Micron 40:386-93. 2009
    ..We believe that VSELs could be harnessed as a source of pluripotent stem cells for regenerative medicine...

Research Grants74

  1. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    ....
  2. Improved Adventitial Sirolimus Therapy for Peripheral Artery Restenosis
    KIRK SEWARD; Fiscal Year: 2010
    ....
  3. Lifespan Extension Despite Greatly Elevated Insulin and Body Fat
    David E Harrison; Fiscal Year: 2013
    ..IL-6, and TNF-alpha);circulating and tissue levels of free fatty acids, triglyceride and cholesterol;and fat cell size distribution in mesenteric and subcutaneous fat tissue...
  4. Analysis of FIP200 in signal transduction
    Jun Lin Guan; Fiscal Year: 2012
    ..with studies in vitro, deletion of FIP200 led to an increased activity of TSC1-TSC2 complex and corresponding cell size decrease in the embryos...
  5. Differentiation of Cord Blood Mesenchymal Stem Cells to Corneal Endothelium
    Nancy C Joyce; Fiscal Year: 2010
    ..Corneas will also be removed at weekly intervals to monitor cell size, shape, and number, and to test for maintenance of a contact-inhibited monolayer...
  6. Redox Regulation of Kv Channels
    SRINIVAS TIPPARAJU; Fiscal Year: 2013
    ..These findings could provide insights into the development of new therapeutic interventions for the treatment and management of myocardial ischemic injury. ..
  7. TGF-BETA, CHLORIDE CHANNELS AND MIGRATION OF EOSINOPHILS
    Devendra K Agrawal; Fiscal Year: 2012
    ..The information obtained from this study should provide an opportunity to formulate superior therapeutic approaches in chronic asthma. ..
  8. Role of Leucine Metabolism in Leucine Signaling
    CHRISTOPHER JOHN LYNCH; Fiscal Year: 2010
    ..It also has an obesity- related metabolic phenotype: decreased adipose tissue mass and fat cell size, markedly improved insulin sensitivity and glucose tolerance, increased feeding-related energy expenditure and ..
  9. PROTECTIVE EFFECTS OF DELAYED CORD CLAMPING IN VLBW INFANTS
    JUDITH SMITH MERCER; Fiscal Year: 2012
    ..If delaying cord clamping at the births of preterm infants lowers rates of intraventricular hemorrhage and late onset sepsis it may have a dramatic effect on the health and well being of these infants. ..
  10. Cellular Mechanisms of Hypothalamic Inflammation in High Fat Diet-Induced Obesity
    Joshua P Thaler; Fiscal Year: 2013
    ..At the same time, an increase in microglial number and cell size occurs in the arcuate nucleus, a region of the hypothalamus containing leptin-responsive melanocortin (POMC) ..
  11. Scale-Up from Pilot To High-Throughput Screen for Inhibitors of Aquaporin-4
    Marc F Pelletier; Fiscal Year: 2011
    ..These compounds are currently under development in a Phase II SBIR. With the current screening technologies in place, we are ready to scale-up our drug discovery program to complete a more thorough search for new drug candidates. ..
  12. Mechanotransduction in the Ciliary Muscle
    Andrew D Pucker; Fiscal Year: 2013
    ..of [unreadable]-smooth muscle actin ([unreadable]-SMA) along with myosin light chain kinase (MLCK) and increased cell size are known markers of hypertrophy...
  13. Ovarian hormone suppression and regulation of adipogenesis in women
    Wendy M Kohrt; Fiscal Year: 2012
    ..e., increase in cell number) in abdominal adipose tissue. This will be assessed by measuring the changes in cell size distribution and the incorporation of deuterium (2H) into DNA of cells in the non-stromal (i.e...
  14. Mechanism of Heat Shock Protein Induction by Glutamine
    Paul E Wischmeyer; Fiscal Year: 2012
    ..abstract_text> ..
  15. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    Vijay Lyall; Fiscal Year: 2010
    ..The research will reveal how the sour taste defense mechanism functions to prevent the ingestion of acids. ..
  16. Second-hit and sexual dimorphism effects in PAH
    Pravin B Sehgal; Fiscal Year: 2013
    ..subcellular level, endothelial and smooth muscle cells in the lung vascular lesions of PAH have an increase in cell size ("megalocytosis"), characteristic cytoplasmic organellar changes (Golgi apparatus fragmentation, cystic ..
  17. Role of U19/Eaf2 in androgen-dependent prostate homeostasis
    Zhou Wang; Fiscal Year: 2013
    ..Interestingly, U19 KO increased the size of prostate epithelial cells, indicating that U19 is essential in cell size control...
  18. DEVELOPING SOLUTES AS STRUCTURAL/MECHANISTIC PROBES OF PROTEIN-DNA INTERACTIONS
    M Thomas Record; Fiscal Year: 2013
    ....
  19. The role of mitochondrial energetics in adaptive thermogenesis with overfeeding
    DARCY LARAE JOHANNSEN; Fiscal Year: 2013
    ..In this proposal, the Candidate will utilize a funded study ("Fat Cell Size, Overfeeding &Ectopic Fat";Funding: R01-DK060412-06A1;PI: Ravussin, E) to investigate adaptive thermogenesis ..
  20. Pathogenesis of TSC2-Related Tumors
    Raymond Yeung; Fiscal Year: 2012
    ..patients with tuberous sclerosis (TSC) develop multiple tumor-like lesions that exhibit aberrant phenotypes in cell size (growth), proliferation, differentiation and migration...
  21. Golgi Blockade in Pulmonary Hypertension
    Pravin B Sehgal; Fiscal Year: 2012
    ..and growth factor signaling, promitogenic signaling and DNA synthesis, resistance to apoptosis, increased cell size and cell migration and thus reduction of the vascular lumen...
  22. Na-K-Cl cotransporter in Glioblastoma Multiforme
    Dandan Sun; Fiscal Year: 2013
    ..Completion of this study will shed light on whether a combined TMZ-based therapy with NKCC1 inhibition presents a novel therapeutic strategy, which may increase the efficiency of the current chemotherapy. ..
  23. Regulation of ClC-3 in Human Malignant Glioma
    Vishnu Anand Cuddapah; Fiscal Year: 2012
    ..Therefore understanding the unique features of glioblastoma biology will lead to the identification of novel targets for the development of therapeutic agents leading to better clinical outcomes. ..
  24. Intestinal Epithelial Function in Congenital Tufting Enteropathy
    MAMATA B SIVAGNANAM; Fiscal Year: 2013
    ..in vitro models we will focus on (1) investigation of the effect of mutation or knockdown of EpCAM on epithelial cell size, morphology and intercellular interactions, (2) characterization of the protein-protein interactions of normal ..
  25. Mechanisms of Regulation Of NHE-1
    John R Raymond; Fiscal Year: 2012
    ..The work could lead to new therapies for hypertension, congestive heart failure, cardiomyopathies and kidney failure. ..
  26. Quantitative Biomarker Imaging for Early Therapy Response Assessment in Cancer
    James M Mountz; Fiscal Year: 2013
    ..Development and use of quantitative imaging for early therapy assessment will greatly facilitate cancer patient management by sparing patients from weeks or months of toxicity and ineffective treatment. ..
  27. Developing Immature Nucleus Pulposus Cells for Regenerative Therapy
    Jun Chen; Fiscal Year: 2013
    ..We have developed a fluorescence-activated cell sorting (FACS) protocol (based on cell size and auto-fluorescence) that identifies a unique population of notochordal-like NP cells with a distinct ..
  28. Molecular Signaling in Adipocytes
    Chi Wing Chow; Fiscal Year: 2013
    ..Increase in cell size/ mass via hypertrophy is the major pathological adaptation in adipocytes to curb the demand for storage of ..
  29. Na+-K+-CI- Cotransporter in Cerebral Ischemia
    Dandan Sun; Fiscal Year: 2012
    ....
  30. Depot-specific Adipogenesis in a Novel Mouse Model of Extended Lifespan
    Cheryl A Conover; Fiscal Year: 2013
    ..in the mesenteric fat depot (mouse equivalent to human visceral fat) where there was a significant reduction in cell size. Were these pre-adipocytes that were not being stimulated to differentiate due to decreased IGF-I ..
  31. Role of the physical microenvironment in tumor cell migration and the cell cycle
    KIMBERLY MURLEY STROKA; Fiscal Year: 2013
    ....
  32. Corneal endothelial cell survival in human donor corneas for transplantation
    Shay Whey M Koh; Fiscal Year: 2012
    ..vasoactive intestinal peptide (VIP) maintains the differentiated state of the corneal endothelium, including CE cell size, shape, and retention, in situ in the human donor cornea, whereas exogenous VIP protects it against the killing ..
  33. TGF-beta-induced non-Smad signaling events and cancer cell behavior
    RIK M DERYNCK; Fiscal Year: 2013
    ..EMT, TGF-[unreadable] activates the PI3-kinase-Akt-TOR pathway, resulting in increased protein synthesis and cell size, and that this pathway mediates the increased motility and invasion of cells that undergo TGF-[unreadable]-..
  34. Lab-on-a-chip Flow Cytometer Using COlor-Space-Time (COST) Coding Method
    JOSE MANUEL MORACHIS; Fiscal Year: 2011
    ..FACS) or flow cytometry enables clinicians and researchers to quantitatively characterize the physical (cell size, shape, granularity) and biochemical (DNA content, cell cycle distribution, cell surface markers, and viability) ..
  35. Trauma-Induced Astrocyte Swelling/Brain Edema: Role of NKCC
    MICHAEL DAVID NORENBERG; Fiscal Year: 2013
    ....
  36. Temporal and Spatial Control of the Cell Cycle in Caulobacter crescentus
    Christine Jacobs-Wagner; Fiscal Year: 2013
    ..Our third aim is to address the intrinsic cell cycle mechanisms that regulate cell size in C. crescentus...
  37. Mechanisms of Environmental Stress Affecting Corneal Epithelial Wound Healing
    Luo Lu; Fiscal Year: 2011
    ..Thus, studies of UV stress-induced signaling events provide significant insight for understanding the mechanisms that underlie the corneal epithelial wound healing processes from damages caused by environmental insults. ..
  38. Mechanism of cell size checkpoint control by a Musahi-like RNA binding protein
    Bradley J S C Olson; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The ability to maintain cell size by balancing growth and division is found in all proliferating cells, but is a poorly understood process...
  39. Ontogeny of erythroid lineage differentiation
    James Palis; Fiscal Year: 2010
    ..However, primitive and definitive red cells also have significant differences in cell size, in transcriptional regulation, and in globin gene expression...
  40. THE ALS GENE FAMILY OF CANDIDA ALBICANS
    Lois L Hoyer; Fiscal Year: 2010
    ..albicans cell size. Aim 3 expands on previous experiments that showed that mutagenesis of ALS5, ALS6 or ALS7 resulted in increased ..
  41. Androgen Receptor Function in White Adipocyte Development
    Bin He; Fiscal Year: 2010
    ..Obesity is caused by increased fat cell number and fat cell size, resulting in increased adipose tissue mass...
  42. mTOR in Growth and Protection of Hypertrophying Myocardium
    Dhandapani Kuppuswamy; Fiscal Year: 2012
    ..of hormone-induced growth and is uniquely positioned to organize components regulating translational machinery, cell size, and deleterious protein removal via the ubiquitin-proteasome system (UPS)...
  43. Alternate day fasting for weight loss, weight maintenance, and cardio-protection
    KRISTA AMY VARADY; Fiscal Year: 2013
    ..size, and CRP) and emerging CHD risk parameters (fat cell- derived hormones, body fat distribution, and fat cell size) in comparison to CR;and Aim 3: To establish that ADMF is an effective diet therapy to maintain weight loss and ..
  44. Investigation of Electrolyte Homeostasis via Quantitative Proteomics
    Jesse Rinehart; Fiscal Year: 2013
    ..Therefore, understanding mechanisms that control electrolyte homeostasis is important for human health. ..
  45. TEMPORAL AND SPATIAL CONTROL OF BACTERIAL CYTOKINESIS
    PETRA A LEVIN; Fiscal Year: 2013
    ..the activity of UgtP and OpgH, division inhibitors that contribute to growth rate-dependent increases in cell size in B. subtilis and E...
  46. EXPANDING THE APPLICATION OF MRI FOR BODY FAT STUDIES IN HUMANS
    Houchun H Hu; Fiscal Year: 2013
    ..at 3 Tesla is investigated in the quantification and characterization of ectopic organ and muscle fat, fat cell size of white adipocytes, and brown adipose tissue...
  47. A New Paradigm for Cell Size Control by the RB Tumor Suppressor Pathway
    James Umen; Fiscal Year: 2013
    ..we have identified key components of a size checkpoint pathway whose behavior suggests a mechanism for coupling cell size to cell cycle activation...
  48. Conduction System Remodeling After Myocardial Infarction
    TERRENCE XAVIER O'BRIEN; Fiscal Year: 2011
    ..Determine the hypertrophic response of the peripheral conduction system after myocardial infarction in terms of cell size, gap junction morphology and cardiomyocyte peripheral conduction system markers...
  49. Active transmembrane water cycling kinetics: A Cellular Metabolic 1H MR Biomarker
    JAMES ALVIN BALSCHI; Fiscal Year: 2013
    ..For example, acute renal failure involves loss of renal transport activity (and likely, water fluxes). Potentially our method will define the severity of metabolic damage, which will likely correlate with prognosis. ..
  50. Lab-on-a-chip Flow Cytometer Using COlor-Space-Time (COST) Coding Method
    JOSE MANUEL MORACHIS; Fiscal Year: 2012
    ..FACS) or flow cytometry enables clinicians and researchers to quantitatively characterize the physical (cell size, shape, granularity) and biochemical (DNA content, cell cycle distribution, cell surface markers, and viability) ..
  51. Role of anion transporters in the regulation of PMN chemotaxis
    ALEXANDRA PAIGE DAVIS VOLK; Fiscal Year: 2012
    ..The current project will significantly advance the understanding of neutrophil migration mechanisms that can ultimately be translated into therapeutic strategies to reduce the burden of illness and disability due to sepsis ..
  52. Fat Cell Size, Overfeeding &Ectopic Fat
    Eric Ravussin; Fiscal Year: 2011
    ..We hypothesize that individuals with both a poor potential for adipose tissue expansion and an impaired function of muscle mitochondria will have the most deterioration of insulin sensitivity after 8 weeks of overfeeding. ..
  53. Examination of the Pre-pubertal Mammalian Growth Plate
    MICHELE REBECCA HUTCHISON; Fiscal Year: 2010
    ..gradient centrifugation into fractions that correspond to the recognized zones of the growth plate, based on cell size, glycogen content and expression patterns of genes known to be differentially expressed in histologic growth ..
  54. KLF15 as novel regulator of cardiomyocyte biology
    MUKESH KUMAR JAIN; Fiscal Year: 2010
    ..cardiomyocytes is a common response to mechanical and hemodynamic stress and is characterized by an increase in cell size, protein synthesis, and re-expression of fetal genes...
  55. Amphibian Models for Bodywall Patterning
    Ann Campbell Burke; Fiscal Year: 2010
    ..include the relative simplicity of the thoracic and abdominal body wall relative to amniote systems, the large cell size facilitating identity of mixed lineage populations, and the abundant molecular and developmental techniques ..
  56. The CLC-3 chloride channels in the heart
    DAYUE DARREL DUAN; Fiscal Year: 2013
    ....
  57. Role of TSC Proteins in Neuronal Polarity and Axon Guidance
    Mustafa Sahin; Fiscal Year: 2010
    ..decade, significant progress has been made in identifying a function for TSC in regulating protein synthesis and cell size. However, the cause of the neurological symptoms in TSC patients has not yet been resolved...
  58. Water and solute transport in the epididymis
    Sylvie Breton; Fiscal Year: 2010
    ..abstract_text> ..
  59. The role of deregulated protein synthesis control in Myc-induced tumorigenesis
    Davide Ruggero; Fiscal Year: 2013
    ..Our findings demonstrate that the ability of Myc to increase protein synthesis directly augments cell size and is sufficient to accelerate cell cycle progression independently of known cell cycle targets ..
  60. Mechanism of Compensatory Renal Hypertrophy
    Jian Kang Chen; Fiscal Year: 2013
    ..protein synthesis in the remaining nephron segments, particularly the proximal tubule, leading to increased cell size and mass but not cell number. This type of growth is termed compensatory renal hypertrophy (CRH)...
  61. Systems Biology of In Vivo Human Blood Cell Populations
    JOHN MATTHEW HIGGINS; Fiscal Year: 2012
    ..as well as how these rates vary among individual patients and within patient cell populations as a function of cell size, age, nuclear complexity, and other single-cell characteristics...
  62. THEORY OF SOLUTE AND WATER TRANSPORT ACROSS EPITHELIA
    Alan M Weinstein; Fiscal Year: 2013
    ..However, the impact on overall kidney function maybe far-reaching, affecting other segments, both adjacent and at a distance. Such models can rationalize whole-organ malfunction as the consequence of a molecular defect. ..
  63. Blood Brain Barrier Physiology and HIV Dementia
    HOWARD GENDELMAN; Fiscal Year: 2007
    ..The data acquired could provide new insights and therapeutic intervention strategies for monocyte BBB trafficking during progressive HIV-1 infection in brain tissue. ..
  64. EFFECT OF CHRONIC AMYLOSE FEEDING IN ADIPOSITY
    DANIEL BESSESSEN; Fiscal Year: 2001
    ..In addition, it has recently been shown that amylose feeding effects adipocyte morphology in rats reducing cell size and increase cell number compared with amylopectin- feeding...
  65. Role of CIC-3 channels in regulation of cell volume and shape in neutrophils
    Jessica Moreland; Fiscal Year: 2007
    ..The studies proposed will advance our fundamental knowledge of the function of neutrophils in the maintenance of normal immune system function. [unreadable] [unreadable] [unreadable]..
  66. Volume Regulatory Pathways in Cystic Fibrosis Mice
    Won Kyoo Cho; Fiscal Year: 2003
    ..abstract_text> ..
  67. Cell Volume Regulation in Neurons and Glia
    FRANCISCO ALVAREZ LEEFMANS; Fiscal Year: 2006
    ..abstract_text> ..
  68. CELL CYCLE PROTEINS IN RENAL GROWTH, INJURY, AND REPAIR
    PATRICIA PREISIG; Fiscal Year: 2004
    ..involve both hyperplasia (resulting in an increase in cell number) and hypertrophy (resulting in an increase in cell size)...
  69. FAT CELL PROLIFERATION IN OBESITY--MODULATING FACTORS
    Roy Martin; Fiscal Year: 1999
    ..It is currently believed that reaching a "critical" fat cell size (FCS) in adipose tissue stimulates increases in fat cell number (FCN)...
  70. Regulation of neural cell volume by thrombin receptors
    Tooba Cheema; Fiscal Year: 2006
    ..abstract_text> ..
  71. The Role of Cell Size and G1-phase Cdks in Cell Growth Control
    Brandt L Schneider; Fiscal Year: 2010
    ..that G1-phase cyclin expression, and importantly, the proliferation rate of cells, is strongly linked to cell size;large cells express G1-phase cyclins sooner and to higher levels as compared to small cells...
  72. MUSCARINIC RECEPTOR COUPLING TO INOSITIDES IN CNS
    Stephen Fisher; Fiscal Year: 2006
    ..Accordingly, knowledge of the signal transduction pathways that regulate VSOAC is an essential prerequisite for the rational design of therapeutic agents. ..
  73. SEQUENTIAL ANALYSIS OF HEMATOLOGIC MEASUREMENTS
    Christine McLaren; Fiscal Year: 1992
    ....
  74. SWELLING ACTIVATED CURRENTS AND MYOCYTE VOLUME IN CHF
    CLIVE BAUMGARTEN; Fiscal Year: 2004
    ..Further, this work may lead to new approaches to treat or prevent CHF and thereby, reduce the morbidity and mortality of this common disease. ..