cell respiration

Summary

Summary: The metabolic process of all living cells (animal and plant) in which oxygen is used to provide a source of energy for the cell.

Top Publications

  1. ncbi Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
    M Y El-Mir
    Laboratoire de Bioénergétique Fondamentale et Appliquée, Universite Joseph Fourier, F 38041 Grenoble Cedex 09, France
    J Biol Chem 275:223-8. 2000
  2. ncbi HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
    Ryo Fukuda
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 129:111-22. 2007
  3. pmc MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake
    Fabiana Perocchi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nature 467:291-6. 2010
  4. ncbi Respiratory active mitochondrial supercomplexes
    Rebeca Acín-Pérez
    Departamento de Bioquimica, Universidad de Zaragoza, Miguel Servet, 177, 50013 Zaragoza, Spain
    Mol Cell 32:529-39. 2008
  5. ncbi Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
    Rui Hua Xu
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:613-21. 2005
  6. pmc Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:18746-51. 2008
  7. pmc NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration
    Claudio Mauro
    Section of Inflammation and Signal Transduction, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Nat Cell Biol 13:1272-9. 2011
  8. pmc Investigation of mitochondrial dysfunction by sequential microplate-based respiration measurements from intact and permeabilized neurons
    Pascaline Clerc
    Department of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e34465. 2012
  9. pmc Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species
    Brian P Dranka
    Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, 35294, USA
    Free Radic Biol Med 48:905-14. 2010
  10. ncbi Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport
    Alisdair R Fernie
    Department of Lothar Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Curr Opin Plant Biol 7:254-61. 2004

Research Grants

  1. MECHANISM OF RESPIRATION AND ENERGY TRANSDUCTION
    Bernard Trumpower; Fiscal Year: 2009
  2. ELECTRON PARAMAGNETIC RESONANCE SPECTROMETER
    Cecilia Giulivi; Fiscal Year: 2009
  3. Novel Hydrogen Sulfide Sensors for Portable Monitors
    Stephen Williams; Fiscal Year: 2004
  4. Mechanoregulation of endothelial mitochondrial function
    BARBARA ALEVRIADOU; Fiscal Year: 2009
  5. Mechanisms of Nitric Oxide Mediated Cell Injury
    DAVID JOURD HEUIL; Fiscal Year: 2005
  6. OSTEOARTHRITIS/CHONDROCALCINOSIS: MITOCHONDRIAL THERAPY
    Anne Murphy; Fiscal Year: 2003
  7. CONTINUOUS-FLOW SYSTEM FOR HYBRIDOMA MICROENCAPSULATION
    HARRIS GOLD; Fiscal Year: 1990
  8. SYNTHESIS OF SELECTIVE DEHYDROGENASE INHIBITORS
    EUGENE COATS; Fiscal Year: 1980
  9. Mitochondrial Dysfunction in Aged Muscle
    David J Marcinek; Fiscal Year: 2010
  10. Mitochondrial control of neuronal excitotoxicity
    David Nicholls; Fiscal Year: 2005

Detail Information

Publications263 found, 100 shown here

  1. ncbi Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I
    M Y El-Mir
    Laboratoire de Bioénergétique Fondamentale et Appliquée, Universite Joseph Fourier, F 38041 Grenoble Cedex 09, France
    J Biol Chem 275:223-8. 2000
    ....
  2. ncbi HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
    Ryo Fukuda
    Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 129:111-22. 2007
    ..Thus, mammalian cells respond to hypoxia by altering COX subunit composition, as previously observed in yeast, but by a completely different molecular mechanism...
  3. pmc MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake
    Fabiana Perocchi
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nature 467:291-6. 2010
    ..Its discovery may lead to the complete molecular characterization of mitochondrial calcium uptake pathways, and offers genetic strategies for understanding their contribution to normal physiology and disease...
  4. ncbi Respiratory active mitochondrial supercomplexes
    Rebeca Acín-Pérez
    Departamento de Bioquimica, Universidad de Zaragoza, Miguel Servet, 177, 50013 Zaragoza, Spain
    Mol Cell 32:529-39. 2008
    ..Therefore, we have demonstrated the existence of a functional respirasome and propose a structural organization model that accommodates these findings...
  5. ncbi Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
    Rui Hua Xu
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:613-21. 2005
    ..Because the Warburg effect and hypoxia are frequently seen in human cancers, these findings may have broad clinical implications...
  6. pmc Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration
    Tatiana K Rostovtseva
    Laboratory of Physical and Structural Biology, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:18746-51. 2008
    ..Additionally, tubulins that have lost significant length or anionic character are only found in cells that do not have mitochondria...
  7. pmc NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration
    Claudio Mauro
    Section of Inflammation and Signal Transduction, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
    Nat Cell Biol 13:1272-9. 2011
    ..Our findings identify NF-κB as a physiological regulator of mitochondrial respiration and establish a role for NF-κB in metabolic adaptation in normal cells and cancer...
  8. pmc Investigation of mitochondrial dysfunction by sequential microplate-based respiration measurements from intact and permeabilized neurons
    Pascaline Clerc
    Department of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
    PLoS ONE 7:e34465. 2012
    ..Sequential measurements of intact and permeabilized cell respiration should be particularly useful for evaluating indirect mitochondrial toxicity due to drugs or cellular ..
  9. pmc Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species
    Brian P Dranka
    Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, 35294, USA
    Free Radic Biol Med 48:905-14. 2010
    ..These data are consistent with a critical role for the mitochondrial reserve capacity in endothelial cells in responding to oxidative stress...
  10. ncbi Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport
    Alisdair R Fernie
    Department of Lothar Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
    Curr Opin Plant Biol 7:254-61. 2004
    ..Recently, a wide range of molecular and biochemical strategies have been adopted to elucidate the functional significance of these interactions...
  11. ncbi Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins
    Daniel L Smith
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, School of Medicine, Charlottesville, VA 22908, USA
    Aging Cell 6:649-62. 2007
    ....
  12. ncbi Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1
    Michelangelo Campanella
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Cell Metab 8:13-25. 2008
    ..Thus, IF(1) regulates mitochondrial function and structure under both physiological and pathological conditions...
  13. ncbi Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stress
    Viviana I Perez
    The Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78229, USA
    Free Radic Biol Med 44:882-92. 2008
    ..Our results suggest that Txn2 plays an important role in protecting the mitochondria against oxidative stress and in sensitizing the cells to ROS-induced apoptosis...
  14. pmc Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetes
    Ronghua Li
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Mol Cell Biol 30:2147-54. 2010
    ..These findings provide new insights into the molecular mechanism of maternally inherited diseases and a step toward therapeutic interventions for these disorders...
  15. ncbi Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria
    Vamsi K Mootha
    MDS Proteomics, Odense 5230, Denmark
    Cell 115:629-40. 2003
    ....
  16. pmc Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalpha
    Nan Wu
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 23:2201-9. 2009
    ..Thus, Rev-erbalpha modulates the synthesis of its own ligand in a negative feedback pathway that maintains heme levels and regulates cellular energy metabolism...
  17. ncbi Photon- and carbon-use efficiency in Ulva rigida at different CO2 and N levels
    Francisco J L Gordillo
    Departamento de Ecologia, Facultad de Ciencias, Universidad de Malaga, Campus de Teatinos, 29071 Malaga, Spain
    Planta 218:315-22. 2003
    ....
  18. ncbi Thermal acclimation of leaf respiration but not photosynthesis in Populus deltoides x nigra
    Lai Fern Ow
    School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    New Phytol 178:123-34. 2008
    ..The R(d)/A(max) ratio declined at higher growth temperatures, and nitrogen status of leaves had little impact on the degree of acclimation...
  19. ncbi Rapid temperature acclimation of leaf respiration rates in Quercus alba and Quercus rubra
    Paul V Bostad
    Department of Forest Resources, 115 Green Hall, University of Minnesota, 1530 Cleveland Ave N, St Paul, MN 55108, USA
    Tree Physiol 23:969-76. 2003
    ..Total nonstructural carbohydrate concentration was slightly, but statistically, lower (13.6 versus 12%, P<0.05) after a 10 degrees C increase in temperature...
  20. pmc Biochemical characterization of the mitochondrial tRNASer(UCN) T7511C mutation associated with nonsyndromic deafness
    Xiaoming Li
    Division and Program in Human Genetics and Center for Hearing and Deafness Research, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
    Nucleic Acids Res 32:867-77. 2004
    ..These observations imply that a combination of the T7511C mutation with two mtDNA mutations accounts for the high penetrance of deafness in this family...
  21. ncbi Cell respiration under hypoxia: facts and artefacts in mitochondrial oxygen kinetics
    Francesca M Scandurra
    Department of General and Transplant Surgery, D Swarovski Research Laboratory, Medical University of Innsbruck, Innsbruck, Austria
    Adv Exp Med Biol 662:7-25. 2010
    ..01 to 0.10 kPa in mitochondria and small cells in the absence of inhibitors of cytochrome c oxidase, whereas experimental artefacts explain the controversial >200-fold range of p (50) in the literature on mitochondrial oxygen kinetics...
  22. ncbi Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletion
    Emi Ogasawara
    Graduate School of Life and Environmental Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8572, Japan
    Hum Mol Genet 19:3179-89. 2010
    ..Our in vivo study also suggested that inhibition of chronic lactic acidemia is a potential strategy for treating some mitochondrial diseases...
  23. pmc Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes
    Blake R Zelickson
    Center for Free Radical Biology, University of Alabama at Birmingham, AL 35294, USA
    Biochim Biophys Acta 1807:1573-82. 2011
    ..These data support the concept that the combined effects of NO and ethanol contribute to an increased susceptibility to hypoxia and the deleterious effects of alcohol consumption on liver...
  24. pmc Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication
    Yuriy Shapovalov
    The Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Biol Chem 286:22331-8. 2011
    ..Our study provides insight into mechanisms of mitochondrial dysfunction in cancer and may offer potential therapeutic targets...
  25. pmc Correction of the consequences of mitochondrial 3243A>G mutation in the MT-TL1 gene causing the MELAS syndrome by tRNA import into mitochondria
    Olga Z Karicheva
    UMR 7156 University of Strasbourg CNRS, Molecular Genetics, Genomics and Microbiology, Strasbourg 67084, France
    Nucleic Acids Res 39:8173-86. 2011
    ..These findings prove the possibility to direct tRNAs with changed aminoacylation specificities into mitochondria, thus extending the potential therapeutic strategy of allotopic expression to address mitochondrial disorders...
  26. ncbi Intracellular O2 sensing probe based on cell-penetrating phosphorescent nanoparticles
    Andreas Fercher
    Biochemistry Department, University College Cork, Cavanagh Building, College Road, Cork, Ireland
    ACS Nano 5:5499-508. 2011
    ..High brightness and photostability allow its use in screening experiments with cell populations on a commercial TR-F reader, and for single cell analysis on a fluorescent microscope...
  27. ncbi Gender dimorphism in rat liver mitochondrial oxidative metabolism and biogenesis
    Roberto Justo
    Grup de Metabolisme Energetic i Nutricio, Departament de Biologia Fonamental i Ciencies de la Salut, Institut Universitari d Investigacio en Ciencies de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain
    Am J Physiol Cell Physiol 289:C372-8. 2005
    ....
  28. ncbi Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy
    Daniela Valenti
    Institute of Biomembranes and Bioenergetics, National Research Council CNR, Bari, Italy
    Biochem J 431:299-310. 2010
    ..These results provide new insight into the molecular basis for mitochondrial dysfunction in DS and might provide a molecular explanation for some clinical features of the syndrome...
  29. pmc Cyclosporine A attenuates mitochondrial permeability transition and improves mitochondrial respiratory function in cardiomyocytes isolated from dogs with heart failure
    Victor G Sharov
    Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit, Michigan 48202, USA
    J Mol Cell Cardiol 42:150-8. 2007
    ..Attenuation of calcein exit, DeltaPsi(m) and improvement of state-3 respiration achieved with CsA (0.2 microM) show that permeability transition opening could be a cause of mitochondrial dysfunction described in the failing heart...
  30. ncbi Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress
    Tim J Schulz
    Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
    Cell Metab 6:280-93. 2007
    ....
  31. pmc Evaluating a new method to estimate the rate of leaf respiration in the light by analysis of combined gas exchange and chlorophyll fluorescence measurements
    Xinyou Yin
    Centre for Crop Systems Analysis, Department of Plant Sciences, Wageningen University, PO Box 430, 6700 AK Wageningen, The Netherlands
    J Exp Bot 62:3489-99. 2011
    ....
  32. ncbi Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply
    E Gnaiger
    D Swarovski Research Laboratory, Department of Transplant Surgery, University Hospital Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
    Respir Physiol 128:277-97. 2001
    ..Bioenergetics at low oxygen versus oxidative stress must be considered in the context of limitation of maximum aerobic activity, ischemia-reperfusion injury, mitochondrial signalling to apoptosis, and mitochondrial theories of ageing...
  33. ncbi Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolism
    Chun Pong Lee
    Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, 35 Stirling Highway, Crawley 6009, Western Australia, Australia
    Mol Cell Proteomics 7:1297-316. 2008
    ....
  34. pmc The basal proton conductance of mitochondria depends on adenine nucleotide translocase content
    Martin D Brand
    Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Biochem J 392:353-62. 2005
    ..We conclude that half to two-thirds of the basal proton conductance of mitochondria is catalysed by the adenine nucleotide carrier, independently of its ATP/ADP exchange or fatty-acid-dependent proton-leak functions...
  35. pmc Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system
    Derek A Drechsel
    Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 285:27850-8. 2010
    ..These findings implicate respiration- and thioredoxin-dependent ROS removal as a potentially important mitochondrial function that may contribute to physiological and pathological processes in the brain...
  36. ncbi Bioenergetic consequences of opening the ATP-sensitive K(+) channel of heart mitochondria
    A J Kowaltowski
    Department of Biochemistry and Molecular Biology, Oregon Graduate Institute of Science and Technology, Beaverton, Oregon 97006-8921, USA
    Am J Physiol Heart Circ Physiol 280:H649-57. 2001
    ..Thus opening mitochondrial K(ATP) channels has little direct effect on respiration, membrane potential, or Ca(2+) uptake but has important effects on matrix and intermembrane space volumes...
  37. ncbi Spare respiratory capacity, oxidative stress and excitotoxicity
    David G Nicholls
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Biochem Soc Trans 37:1385-8. 2009
    ..Mitochondria play a central role in the survival or death of the exposed neuron. Calcium, oxidative stress and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures...
  38. ncbi Global convergence in the temperature sensitivity of respiration at ecosystem level
    Miguel D Mahecha
    Max Planck Institute for Biogeochemistry, 07745 Jena, Germany
    Science 329:838-40. 2010
    ..The results may partly explain a less pronounced climate-carbon cycle feedback than suggested by current carbon cycle climate models...
  39. ncbi Fatty acids as modulators of the cellular production of reactive oxygen species
    Peter Schonfeld
    Institute of Biochemistry and Cell Biology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
    Free Radic Biol Med 45:231-41. 2008
    ..These effects of FFA can modulate signaling functions of ROS and be, at least partly, responsible for their proapoptotic effects in several types of cells...
  40. ncbi Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone
    Nagendra Yadava
    Buck Institute for Age Research, Novato, California 94945, USA
    J Neurosci 27:7310-7. 2007
    ..The bioenergetic consequences of rotenone addition were quantified by monitoring cell respiration. Glutamate activation of NMDA receptors used the full respiratory capacity of the in situ mitochondria, and >..
  41. ncbi Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidase
    B Kadenbach
    Fachbereich Chemie, Philipps Universitat, Marburg, Germany
    Free Radic Biol Med 29:211-21. 2000
    ..High substrate pressure (sigmoidal v/s kinetics), palmitate and 3,5-diiodothyronine (binding to subunit Va) increase also delta p, ROS production and slip but without dephosphorylation of COX...
  42. pmc Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
    J J Lehman
    Department of Medicine, and Department of Pathology, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 106:847-56. 2000
    ..These results identify PGC-1 as a critical regulatory molecule in the control of cardiac mitochondrial number and function in response to energy demands...
  43. ncbi Butyrate metabolism upstream and downstream acetyl-CoA synthesis and growth control of human colon carcinoma cells
    X Leschelle
    Laboratoire de Nutrition et Securite Alimentaire, Institut National de la Recherche Agronomique, Jouy en Josas, France
    Eur J Biochem 267:6435-42. 2000
    ..In contrast, the metabolism downstream of acetyl-CoA [i.e. oxidation in the tricarboxylic acid (TCA) cycle and lipid synthesis] likely acts as a regulator of butyrate intracellular concentration...
  44. pmc Mitochondrial K(ATP) channels in cell survival and death
    Hossein Ardehali
    Institute of Molecular Cardiobiology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205 2195, USA
    J Mol Cell Cardiol 39:7-16. 2005
    ..In this review, we attempt to highlight the recent advances in the physiological role of mitoK(ATP) and discuss the controversies and unanswered questions...
  45. ncbi Functional delivery of a cytosolic tRNA into mutant mitochondria of human cells
    Bidesh Mahata
    Genetic Engineering, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Calcutta 700032, India
    Science 314:471-4. 2006
    ..The use of protein complexes to modulate mitochondrial function may help in the management of such genetic disorders...
  46. ncbi Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1
    P Puigserver
    Dana Farber Cancer Institute, Department of Cell Biology, Boston, MA 02115, USA
    Mol Cell 8:971-82. 2001
    ..These data illustrate a direct thermogenic action of cytokines and p38 MAP kinase through the transcriptional coactivator PGC-1...
  47. ncbi Analysis of intracellular oxygen and metabolic responses of mammalian cells by time-resolved fluorometry
    Alexander V Zhdanov
    Luxcel Biosciences Ltd, BioInnovation Centre, UCC, Cork, Ireland
    Anal Chem 79:9414-9. 2007
    ..The assay provides relevant, information-rich data on cellular function and metabolism. It allows monitoring of small, rapid, and transient changes in cell respiration and screening of new chemical entities.
  48. ncbi Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
    James J Palacino
    Center for Neurologic Diseases, Brigham and Women s Hospital, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:18614-22. 2004
    ....
  49. ncbi Cytochrome c oxidase maintains mitochondrial respiration during partial inhibition by nitric oxide
    Miriam Palacios-Callender
    Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK
    J Cell Sci 120:160-5. 2007
    ..of mitochondrial cytochrome c oxidase (CcO) at O2 concentrations ([O2]) above those at which it inhibits cell respiration. Thus, in cells respiring to anoxia, the addition of 2...
  50. ncbi Interactive effects of temperature and precipitation on soil respiration in a temperate maritime pine forest
    J Curiel Yuste
    University of Antwerpen, Department of Biology, Research Group of Plant and Vegetation Ecology, Universiteitsplein 1, B 2610 Wilrijk, Belgium
    Tree Physiol 23:1263-70. 2003
    ..Our results revealed that, in addition to temperature and SWC, rain plays a role in determining the total amount of carbon released from soils, even in a maritime climate...
  51. pmc Endothelial mitochondria--less respiration, more integration
    Lukas N Groschner
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Harrachgasse 21 III, 8010, Graz, Austria
    Pflugers Arch 464:63-76. 2012
    ..In this review, we want to outline the significance of mitochondria in both physiology and pathology of the vascular endothelium...
  52. ncbi The mystery of reactive oxygen species derived from cell respiration
    Hans Nohl
    Basic Research in Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria
    Acta Biochim Pol 51:223-9. 2004
    ..However, changing the physical membrane state affected the highly susceptible interaction of the ubiquinol/bc(1) redox complex such that ROS formation became possible...
  53. ncbi SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes
    Tong Shi
    United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 280:13560-7. 2005
    ..In summary, our results demonstrate that SIRT3 activates mitochondria functions and plays an important role in adaptive thermogenesis in brown adipose...
  54. pmc Increased potassium conductance of brain mitochondria induces resistance to permeability transition by enhancing matrix volume
    Magnus J Hansson
    Mitochondrial Pathophysiology Unit, Laboratory for Experimental Brain Research, Department of Clinical Sciences, Lund University, SE 221 84 Lund, Sweden
    J Biol Chem 285:741-50. 2010
    ..We propose that increased potassium conductance in brain mitochondria may cause a direct physiological effect on matrix volume inducing resistance to pathological calcium challenges...
  55. pmc Function of mitochondrial Stat3 in cellular respiration
    Joanna Wegrzyn
    Department of Biochemistry and Molecular Biology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
    Science 323:793-7. 2009
    ..These data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis...
  56. ncbi Genotype effects on internal gas gradients in apple fruit
    Q Tri Ho
    Flanders Centre of Postharvest Technology BIOSYST MeBioS, Faculty of Bioscience Engineering, Katholieke Universiteit Leuven, Willem de Croylaan 42, Leuven, Belgium
    J Exp Bot 61:2745-55. 2010
    ..Kanzi had less O(2) anoxia at CA storage compared with Braeburn...
  57. ncbi Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response
    N Moisoi
    Cell Death Regulation Laboratory, MRC Toxicology Unit, Leicester LE1 9HN, UK
    Cell Death Differ 16:449-64. 2009
    ..We therefore propose that this brain-specific transcriptional response to stress may be important in the advance of neurodegenerative diseases...
  58. pmc Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F₁F0-ATP synthase
    Marie Bergeaud
    Laboratoire de génétique et biologie cellulaire LGBC Université de Versailles St Quentin en Yvelines Ecole Pratique des Hautes Etudes UFR des Sciences de la Santé Montigny le Bretonneux, France
    Cell Cycle 12:2781-93. 2013
    ....
  59. pmc Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin
    Ravindar R Thomas
    Morris Udall Parkinson s Disease Research Center of Excellence, University of Virginia, Charlottesville, VA, United States
    Mitochondrion 11:108-18. 2011
    ..rhTFAM treatment improved motor recovery rate after treatment with MPTP and dose-dependently improved survival in the lipopolysaccharide model of endotoxin sepsis...
  60. pmc Meclizine is neuroprotective in models of Huntington's disease
    Vishal M Gohil
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Hum Mol Genet 20:294-300. 2011
    ..Since meclizine is an approved drug that crosses the blood-brain barrier, it may hold therapeutic potential in the treatment of polyQ toxicity disorders, such as Huntington's disease...
  61. pmc Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines
    Therese Bredholt
    The Gade Institute, University of Bergen, Bergen, Norway
    Mol Cancer 8:101. 2009
    ..The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with khat in a panel of acute myeloid leukemia cell lines to elucidate mechanisms of toxicity...
  62. ncbi The carbon monoxide-releasing molecule, CORM-3 (RU(CO)(3) CL(glycinate)), targets respiration and oxidases in Campylobacter jejuni, generating hydrogen peroxide
    Holly Smith
    Department of Molecular Biology and Biotechnology, University of Sheffield, UK
    IUBMB Life 63:363-71. 2011
    ..This work shows that CO-RMs have valuable properties as antimicrobial agents; however, growth inhibition does not always accompany inhibition of respiration, even when ambient oxygen concentrations are low...
  63. ncbi The ADP and ATP transport in mitochondria and its carrier
    Martin Klingenberg
    Institut Physiologische Chemie der Universität München, Germany
    Biochim Biophys Acta 1778:1978-2021. 2008
    ..Being a snapshot of an extreme abortive "c-state" the actual mechanism still remains a conjecture...
  64. pmc Inter-connection between mitochondria and HIFs
    Kathryn V Tormos
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 2909, USA
    J Cell Mol Med 14:795-804. 2010
    ..In this review, we examine the evidence that mitochondria and HIFs are intimately connected to regulate each other resulting in appropriate responses to hypoxia...
  65. ncbi Cryopreservation of mitochondria and mitochondrial function in cardiac and skeletal muscle fibers
    Andrey V Kuznetsov
    Department of Transplant Surgery, University Hospital Innsbruck, Austria
    Anal Biochem 319:296-303. 2003
    ..This will significantly expand the scope for screening and exchange of human biopsy samples between research centers, thus providing a new basis for functional analysis of mitochondrial defects in various diseases...
  66. ncbi Nuclear background determines biochemical phenotype in the deafness-associated mitochondrial 12S rRNA mutation
    M X Guan
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Hum Mol Genet 10:573-80. 2001
    ....
  67. pmc Regulation of cytochrome c oxidase activity by c-Src in osteoclasts
    Tsuyoshi Miyazaki
    Department of Cell Biology, Yale University School of Medicine, PO Box 208044, New Haven, CT 06520 8044, USA
    J Cell Biol 160:709-18. 2003
    ..These results suggest that c-Src plays a previously unrecognized role in maintaining cellular energy stores by activating Cox in mitochondria...
  68. ncbi Respiratory chain supercomplexes
    H Schagger
    Zentrum der Biologischen Chemie, Universitatsklinikum Frankfurt, Frankfurt am Main, Germany
    IUBMB Life 52:119-28. 2001
    ..Dimeric ATP synthase seems to be specific for mitochondrial OXPHOS systems. Monomeric complex V was found in Acetobacterium woodii and Paracoccus denitrificans...
  69. pmc Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitrite
    Charles I Jones
    Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
    Am J Physiol Cell Physiol 295:C180-91. 2008
    ..Hence, the hyperoxia of in vitro EC flow studies, via increased NO and mitochondrial O(2)(*-) production, leads to enhanced ONOO(-) formation intramitochondrially and suppression of respiration...
  70. ncbi Imaging of oxygen gradients in monolayer cultured cells using green fluorescent protein
    Eiji Takahashi
    Biomedical Engineering Course, Advanced Technology Fusion, Graduate School of Science and Engineering, Saga Univ, Saga 840 8502, Japan
    Am J Physiol Cell Physiol 299:C1318-23. 2010
    ..Findings in the present two-dimensional O(2) diffusion model support the crucial role of tissue O(2) diffusion in defining the O(2) microenvironment in individual cells...
  71. pmc H2O2-induced mitochondrial fragmentation in C2C12 myocytes
    Xiying Fan
    Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
    Free Radic Biol Med 49:1646-54. 2010
    ..Because H(2)O(2) is produced in contracting muscle, our results raise the possibility that ROS generation may contribute to exercise-induced changes in mitochondrial morphology in vivo...
  72. ncbi A Clark-type oxygen chip for in situ estimation of the respiratory activity of adhering cells
    Ching Chou Wu
    Department of Bio Industrial Mechatronics Engineering, National Chung Hsing University, No 250, Kuo Kuang Road, Taichung 402, Taiwan
    Talanta 81:228-34. 2010
    ..Moreover, the change in the respiration activity of adhering HeLa cells stimulated by the high concentration of glucose or propofol anaesthetic can be monitored in real time with the Clark-type oxygen chip...
  73. ncbi Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptide
    Xin Gao
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi Tech Park, Shanghai 201203, People s Republic of China
    Free Radic Biol Med 46:1454-62. 2009
    ..These direct effects on mitochondria further extend the noncholinergic functions of HupA...
  74. ncbi Inhibitory effects of Bcl-2 on mitochondrial respiration
    M Vrbacky
    Department of Immunology and Microbiology, First Faculty of Medicine of Charles University, Studnickova 7, 128 00 Prague 2, Czech Republic
    Physiol Res 52:545-54. 2003
    ..Based on this observation, we propose that the outcome of Bcl-2 expression is determined by the type of cellular ATP synthesis, namely that Bcl-2 causes apoptosis in cells relying on oxidative phosphorylation...
  75. ncbi The diel imprint of leaf metabolism on the δ13 C signal of soil respiration under control and drought conditions
    Matthias Barthel
    Institute of Agricultural Sciences, ETH Zurich, Universitatsstrasse 2, 8092 Zurich, Switzerland
    New Phytol 192:925-38. 2011
    ..2.5, depending on the photosynthetic rate. Drought slows the coupling between photosynthesis and soil respiration and alters the underlying mechanism causing diel variations of δ(13) C(SR)...
  76. pmc Esterified trityl radicals as intracellular oxygen probes
    Yangping Liu
    Center for Biomedical EPR Spectroscopy and Imaging, The Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, Columbus, OH 43210, USA
    Free Radic Biol Med 46:876-83. 2009
    ..This study demonstrates that these esterified trityl radicals can function as effective EPR oximetry probes measuring intracellular O2 concentration and consumption...
  77. pmc Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria
    Alexander V Zhdanov
    Biochemistry Department, University College Cork, Cavanagh Pharmacy Building, College Road, Cork, Republic of Ireland
    Cell Mol Life Sci 68:903-17. 2011
    ..Cells treated with Baf become more susceptible to excitation with KCl. Such mitochondrial uncoupling may play a role in a number of (patho)physiological conditions induced by Baf...
  78. ncbi Melatonin reduces oxidant damage and promotes mitochondrial respiration: implications for aging
    Russel J Reiter
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Ann N Y Acad Sci 959:238-50. 2002
    ..As of this writing there is no definitive evidence to prove that melatonin alters the rate of aging, although data relating to melatonin deferring some age-related degenerative conditions is accumulating rapidly...
  79. ncbi Starch synthesis and carbon partitioning in developing endosperm
    M J Emes
    School of Biological Sciences, University of Manchester, 3 614 Stopford Building, Manchester M13 9PT, UK
    J Exp Bot 54:569-75. 2003
    ..As ADPG is an activated sugar, the dependence of its production on respiration, changes which occur during development, and the constraints which ATP production may place on carbon partitioning into different end-products are discussed...
  80. pmc The neuromediator glutamate, through specific substrate interactions, enhances mitochondrial ATP production and reactive oxygen species generation in nonsynaptic brain mitochondria
    Alexander Panov
    Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA
    J Biol Chem 284:14448-56. 2009
    ....
  81. ncbi Toll-like receptor-3-induced mitochondrial dysfunction in cultured human hepatocytes
    Siamak Djafarzadeh
    Department of Intensive Care Medicine, Inselspital, Bern University Hospital and University of Bern, 3010 Bern, Switzerland
    Mitochondrion 11:83-8. 2011
    ..Poly-I:C induced activation of NF-κB, and the mitochondrial dysfunction was accompanied by caspase-8 but not caspase-3 activation and by no major alterations in cellular or mitochondrial ultrastructure...
  82. ncbi Effect of amyloid beta-peptide on permeability transition pore: a comparative study
    Paula I Moreira
    Department of Zoology, University of Coimbra, Coimbra, Portugal
    J Neurosci Res 69:257-67. 2002
    ..It can be concluded that brain and liver mitochondria show a different susceptibility to the deleterious effect of A beta peptide, brain mitochondria being more resistant to the potentiation by A beta of Ca(2+)-induced PTP...
  83. pmc Adaptation of microplate-based respirometry for hippocampal slices and analysis of respiratory capacity
    Rosemary A Schuh
    Research Service, Maryland VA Healthcare System, Baltimore, Maryland, USA
    J Neurosci Res 89:1979-88. 2011
    ..When coupled with cell type-specific pharmacology or genetic manipulations, the ability to measure O(2) consumption efficiently from whole slices should advance our understanding of mitochondrial roles in physiology and neuropathology...
  84. ncbi nMAT1, a nuclear-encoded maturase involved in the trans-splicing of nad1 intron 1, is essential for mitochondrial complex I assembly and function
    Ido Keren
    Institute of Plant Sciences, Agricultural Research Organizaion, Volcani Center, Bet Dagan 50250, Israel
    Plant J 71:413-26. 2012
    ..Homozygous nMat1 plants show retarded growth and developmental phenotypes, modified respiration activities and altered stress responses that are tightly correlated with mitochondrial complex I defects...
  85. pmc Mitochondrial DNA background modifies the bioenergetics of NARP/MILS ATP6 mutant cells
    M D'Aurelio
    Weill Medical College of Cornell University, New York, NY 10065, USA
    Hum Mol Genet 19:374-86. 2010
    ..Taken together, these results indicate that the mtDNA background plays an important role in modulating the biochemical defects and clinical outcome in NARP/MILS...
  86. pmc Inhibition of mitochondrial respiration and rapid depletion of mitochondrial glutathione by β-phenethyl isothiocyanate: mechanisms for anti-leukemia activity
    Gang Chen
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Antioxid Redox Signal 15:2911-21. 2011
    ..This study aimed at investigating the key mechanisms that contribute to the potent anti-leukemia activity of PEITC and at evaluating its therapeutic potential...
  87. ncbi Respiration and photosynthesis of bladders and leaves of aquatic utricularia species
    L Adamec
    Institute of Botany of the Academy of Sciences of the Czech Republic, Section of Plant Ecology, Dukelska 135, 379 82 Trebon, Czech Republic
    Plant Biol (Stuttg) 8:765-9. 2006
    ....
  88. pmc The effect of different ubiquinones on lifespan in Caenorhabditis elegans
    Yu Ying Yang
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
    Mech Ageing Dev 130:370-6. 2009
    ..Moreover, when compared to other dietary quinones, UQ(10) further decreased mitochondrial oxidative damage and extended adult lifespan in clk-1...
  89. pmc Effects of drought stress and subsequent rewatering on photosynthetic and respiratory pathways in Nicotiana sylvestris wild type and the mitochondrial complex I-deficient CMSII mutant
    Alexander Galle
    Grup de Recerca en Biologia de les Plantes en Condicions Mediterranies, Departament de Biologia UIB IMEDEA, Universitat de les Illes Balears, Carretera de Valldemossa Km 7 5, E 07122 Palma de Mallorca, Spain
    J Exp Bot 61:765-75. 2010
    ....
  90. ncbi Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties
    Riccardo Rubbiani
    Institute of Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig, Germany
    J Med Chem 53:8608-18. 2010
    ....
  91. ncbi Oxidative metabolism in cancer growth
    Michael Ristow
    Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany
    Curr Opin Clin Nutr Metab Care 9:339-45. 2006
    ....
  92. pmc Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsis
    Fredrik Sjövall
    Mitochondrial Pathophysiology Unit, Laboratory for Experimental Brain Research, Department of Clinical Sciences, Lund University, Solvegatan 17, SE 221 84, Lund, Sweden
    Crit Care 14:R214. 2010
    ..Here we investigated temporal changes in platelet mitochondrial respiratory function in patients with sepsis during the first week after disease onset...
  93. ncbi Biochemical assays of respiratory chain complex activity
    Denise M Kirby
    Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom
    Methods Cell Biol 80:93-119. 2007
  94. ncbi Evidence of mitochondrial involvement in the transduction of signals required for the induction of genes associated with pathogen attack and senescence
    Denis P Maxwell
    Michigan State University Department of Energy Plant Research Laboratory, Michigan State University, East Lansing 48824, USA
    Plant J 29:269-79. 2002
    ..These findings suggest that the mitochondrion may serve an important role in conveying intracellular stress signals to the nucleus, leading to alterations in gene expression...
  95. pmc Genetic modification of alternative respiration has differential effects on antimycin A-induced versus salicylic acid-induced resistance to Tobacco mosaic virus
    Androulla Gilliland
    Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom
    Plant Physiol 132:1518-28. 2003
    ..Other antiviral factors, potentially including the SA-inducible RNA-dependent RNA polymerase, are regulated by AOX-independent mechanisms...
  96. ncbi The pervasive presence of fluctuating oxygenation in tumors
    Laura I Cárdenas-Navia
    Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA
    Cancer Res 68:5812-9. 2008
    ..The widespread presence of fluctuations in tumor oxygenation has broad ranging implications for tumor progression, stress response, and signal transduction, which are altered by oxygenation/reoxygenation events...
  97. ncbi Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochrome c oxidase
    E Gnaiger
    Department of Transplant Surgery, D Swarovski Research Laboratory, University Hospital Innsbruck, Innsbruck, Austria
    J Exp Biol 201:1129-39. 1998
    ..Accordingly, enzymatic capacities are matched in terms of optimum ratios, rather than equal levels, to meet the specific kinetic and thermodynamic demands set by the low-oxygen environment in the cell...
  98. ncbi Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
    Su Ju Lin
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 418:344-8. 2002
    ..We discuss how this metabolic strategy may apply to CR in animals...
  99. ncbi Nitroxia: the pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway
    Sruti Shiva
    Department of Pathology, University of Alabama at Birmingham, BMR II, 901 19th Street South, Birmingham, AL 35294, USA
    Free Radic Biol Med 38:297-306. 2005
    ..We term this unique pathological condition Nitroxia and describe how it may contribute to the pathology of chronic inflammatory diseases using ethanol-dependent hepatotoxicity as an example...
  100. ncbi Influence of chloroplastic photo-oxidative stress on mitochondrial alternative oxidase capacity and respiratory properties: a case study with Arabidopsis yellow variegated 2
    Keisuke Yoshida
    Department of Biological Sciences, Graduate School of Science, Osaka University, 1 1 Machikaneyama cho, Toyonaka, Osaka 560 0043, Japan
    Plant Cell Physiol 49:592-603. 2008
    ..These results indicate that photo-oxidative stress by excess light is involved in the regulation of respiratory gene expression and the modulation of respiratory properties, especially the AOX up-regulation...
  101. pmc A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans
    David Cristina
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 5:e1000450. 2009
    ..Loss of fstr-1/2 does not suppress the phenotypes of all long-lived mitochondrial mutants. Thus, although different mitochondrial perturbations activate similar transcriptional and physiological responses, they do so in different ways...

Research Grants66

  1. MECHANISM OF RESPIRATION AND ENERGY TRANSDUCTION
    Bernard Trumpower; Fiscal Year: 2009
    The cytochrome bc1 complex is an energy-transducing enzyme that participates in cell respiration in oxygen utilizing eukaryotic cells and is located in the inner mitochondrial membrane...
  2. ELECTRON PARAMAGNETIC RESONANCE SPECTROMETER
    Cecilia Giulivi; Fiscal Year: 2009
    ..in the ryanodine receptor type 1;d) nitric oxide as an important modulator of cell respiration and mediator of oxygen gradient redistribution;e) reactive oxygen and nitrogen radicals during caloric ..
  3. Novel Hydrogen Sulfide Sensors for Portable Monitors
    Stephen Williams; Fiscal Year: 2004
    ..is a colorless, flammable gas that is highly toxic It reacts with the enzymes in the blood that inhibit cell respiration At high concentrations, it can literally shut off the lungs, while lower levels can burn the respiratory ..
  4. Mechanoregulation of endothelial mitochondrial function
    BARBARA ALEVRIADOU; Fiscal Year: 2009
    ..its interaction with electron transport chain (ETC) components, may function not only as a regulator of cell respiration, but also to augment the generation of reactive oxygen species (ROS) by mitochondria and thereby trigger ..
  5. Mechanisms of Nitric Oxide Mediated Cell Injury
    DAVID JOURD HEUIL; Fiscal Year: 2005
    ..We propose that S-nitrosation reactions contribute to the inhibition of cell respiration and proliferation that is associated with increased NO production...
  6. OSTEOARTHRITIS/CHONDROCALCINOSIS: MITOCHONDRIAL THERAPY
    Anne Murphy; Fiscal Year: 2003
    ..Importantly, the lead compounds effectively block trigger-induced ATP depletion and inhibition of intact cell respiration. Specific Aim 1 will test whether the efficacy of specific lead compounds is primarily due to direct ..
  7. CONTINUOUS-FLOW SYSTEM FOR HYBRIDOMA MICROENCAPSULATION
    HARRIS GOLD; Fiscal Year: 1990
    ..barrier is how to provide scale-up production of small alginate gel balls, which are necessary to support cell respiration. The objectives of the proposed Phase II program are 91) to develop a full-scale prototype of a process for ..
  8. SYNTHESIS OF SELECTIVE DEHYDROGENASE INHIBITORS
    EUGENE COATS; Fiscal Year: 1980
    ..The results of these studies will be utilized in the design of selective inhibitors of anaerobic and aerobic tumor cell respiration as potential antineoplastic agents.
  9. Mitochondrial Dysfunction in Aged Muscle
    David J Marcinek; Fiscal Year: 2010
    Mitochondria play a key role in linking cell respiration to cell survival and are critical elements in many age- related degenerative pathologies: The mitochondrial theory of aging proposes that oxidative damage leads to irreversible ..
  10. Mitochondrial control of neuronal excitotoxicity
    David Nicholls; Fiscal Year: 2005
    ..4. To test the hypothesis that mitochondria at specific intracellular locations may be selectively vulnerable to glutamate excitotoxicity because of their proximity to NMDA receptors, or their location in regions of high-energy demand. ..
  11. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 2002
    ..abstract_text> ..
  12. Hypoxia-Inducible Factor 1 and Oxygen Homeostasis
    Gregg Semenza; Fiscal Year: 2009
    ....
  13. Aging-Related Models and Mitochondrial Bioenergetics
    David Nicholls; Fiscal Year: 2006
    ..3. To indicate therapeutic strategies whereby the deleterious consequences of aging-related changes in mitochondrial function can be minimized. ..
  14. Control of ATP Producing Pathways in Skeletal Muscle
    Brandon Walsh; Fiscal Year: 2005
    ..determine the role of metabolic channeling in setting the onset kinetics of oxidative phosphorylation, and 3.) determine the intracellular PO2 at which respiration becomes O2 dependent. ..
  15. RESPIRATION AND GLYCOLYSIS--INTEGRATION IN ACTIVE MUSCLE
    Kevin Conley; Fiscal Year: 2002
    ..g., diabetes. An understanding of the integration of metabolism in healthy tissue is the first step to understanding how failure of integration limits function in diseased muscle. ..
  16. Creatine Transport Across the Blood Brain Barrier
    Joseph Clark; Fiscal Year: 2006
    ..The goal for Hypothesis 2 is to develop methods and drugs to improve brain energy metabolism by getting creatine into the brain. ..
  17. Induction of Inflammation by Mitochondrial Proteins
    Elliott Crouser; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  18. PHYSIOLOGY OF THE RESPIRATORY MUSCLES
    Michael Reid; Fiscal Year: 2006
    ..Aim 2. To determine the molecular source(s) and distribution of muscle-derived NO. Aim3. To evaluate principal source(s) of intracellular ROS and mechanisms that regulate ROS activity. ..
  19. Detection of Bioterrorism Agents with PM Technology
    Barry Bochner; Fiscal Year: 2006
    ..abstract_text> ..
  20. XIIIth Biennial Meeting of the Society for Free Radical Research International
    Enrique Cadenas; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  21. REGULATION OF MITOCHONDRIAL BIOGENESIS IN YEAST
    RONALD BUTOW; Fiscal Year: 2007
    ..These experiments should[unreadable] provide additional insights into the function of retrograde regulation.[unreadable]..
  22. MSM Multiscale Modeling of the Heart in Cardiovascular
    DANIEL BEARD; Fiscal Year: 2007
    ..abstract_text> ..
  23. Human mitochondrial fatty acid synthase
    Stuart Smith; Fiscal Year: 2009
    ..Elucidation of the role of the mitFAS system in mitochondrial function may aid in understanding the etiology of these disorders. ..
  24. Integrated Metabolism in Methylobacterium extroquens AM1
    Mary E Lidstrom; Fiscal Year: 2010
    ..This study is expected to result in new principles in metabolic integration, as well new insights into C1 metabolism. ..
  25. GM-CSF responsiveness in alcohol-mediated lung injury
    David Guidot; Fiscal Year: 2009
    ..The ultimate goal of this project is to develop human recombinant GM-CSF as a therapy for patients at high risk for acute lung injury as a consequence of chronic alcohol abuse. ..
  26. Oxidative Stress, Mitochondrial Dysfunction and Aging
    Enrique Cadenas; Fiscal Year: 2009
    ..These mechanisms play a critical role in the progression of the aging process and may precede or modulate age-related oxidative- and nitrosative damages. ..
  27. Mitochondria and Cerebral ischemia: intracellular signaling
    Miguel Perez Pinzon; Fiscal Year: 2009
    ....
  28. Bilirubin oxidation and intracerebral hemorrhage
    Joseph Clark; Fiscal Year: 2009
    ..These studies are important because we believe that strategies designed to prevent BOXes production in the hematoma should provide a novel and beneficial therapeutic option for patients who have suffered an ICH. ..
  29. STRUCTURE AND SPECIFICITY OF LIPOGENIC ENZYMES
    Stuart Smith; Fiscal Year: 2008
    ..abstract_text> ..
  30. HIV-1 and ethanol-induced alveolar epithelial and macrophage dysfunction
    David Guidot; Fiscal Year: 2007
    ..Ultimately, the long-term goal of this project is to identify effective new adjunctive therapies that can complement standard treatment and enhance lung function in HIV-1-infected individuals. [unreadable] [unreadable] [unreadable]..
  31. The Pathogenesis and Genetics of Environmental Asthma
    JONATHAN STAMLER; Fiscal Year: 2007
    ..In aggregate, the coupled scientific findings in this program will substantially enhance our understanding of the pathogenesis and genetics of asthma. ..
  32. Uncoupling Proteins and Species-Dependent Longevity
    Tamas Horvath; Fiscal Year: 2007
    ..Our attempts to provide comparative analyses of age related molecular mechanisms in rodents and nonhuman primates, will provide novel therapeutic targets, UCPs, to increase longevity without compromising tissue function. ..
  33. Uncoupling Protein 2 Promotes Neuronal Survival
    Tamas Horvath; Fiscal Year: 2006
    ..This will furnish one common target for the development of drugs against a variety of neurodegenerative pathologies, including those associated with hypoxia, epilepsy, Parkinson's, Alzheimer's and Huntington's Disease. ..
  34. Ocular HSV-1: Chromatin Remodeling in Latent TG
    DONNA NEUMANN; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  35. Oxidants, Mitochondria,and Renal Ischemia/Reperfusion
    LEE MACMILLAN CROW; Fiscal Year: 2005
    ..This information will be helpful in determining possible therapeutic interventions for improving current techniques in renal preservation and transplantation. ..
  36. MITOCHONDRIAL CYTOCHROME C RELEASE VIA MEMBRANE PORES
    Elliott Crouser; Fiscal Year: 2004
    ..These advisors are actively investigating the role mitochondria in the pathogenesis of disease. Thus, the prospects for successful collaborative initiatives, a critical determinant of future success, are excellent. ..
  37. COREGISTERED IMAGES OF BREAST TUMORS BY MRI AND OPTICAL
    Britton Chance; Fiscal Year: 2003
    ..Large scale tests are available under other support where a direct comparison with not only MRI but also digital mammography, ultrasound and PET will secure the validation studies. ..
  38. Phenotype MicroArrays for Drug Toxicity Screening
    Barry Bochner; Fiscal Year: 2003
    ..In future studies (Phase II SBIR) we will expand the technology and scope of reference drugs tested to build a strong predictive database including cell lines representing more tissues and organs. ..
  39. Biochemical Mechanisms of Vasospasms
    Joseph Clark; Fiscal Year: 2003
    ..The ultimate long-term goal for this project is to define the molecular causes of vasospasm in order to develop effective diagnostic, therapeutic and preventative approaches for this cerebral vascular disease. ..
  40. MOLECULAR AND CHEMICAL DESCRIPTION OF CFTR FUNCTION
    Peter Pedersen; Fiscal Year: 2003
    ..The proposed studies are fundamental to understanding structure/function relationships within CFTR, to understanding the underlying basis of most cases of CF, and to developing new strategies to treat the disease. ..
  41. GONADAL STEROID REGULATION OF THE BIOLOGICAL CLOCK
    Tamas Horvath; Fiscal Year: 2003
    ..abstract_text> ..
  42. BREAST CANCER HYPOXIA ASSESSED BY NITRIC OXIDE
    Britton Chance; Fiscal Year: 2002
    ..If ourintended goals of demonstrating feasibility are achieved, then application for support through regular RO1channels would appear to be justified. ..
  43. P53 AND REPAIR OF DNA DAMAGE BY ANTICANCER DRUGS
    Peng Huang; Fiscal Year: 2002
    ..Furthermore, the inability of mutant p53 to remove nucleoside analogs from DNA may provide a molecular basis for the design of strategies to selectively kill cancer cells with mutant p53 by therapeutic nucleoside analogs. ..
  44. ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHY
    Kendall Wallace; Fiscal Year: 2004
    ....
  45. NO HEMOGLOBIN INTERACTION IN THE PULMONARY VASCULATURE
    JONATHAN STAMLER; Fiscal Year: 2001
    ..abstract_text> ..
  46. GENETIC AND MOLECULAR STUDIES OF GROUP II INTRONS
    RONALD BUTOW; Fiscal Year: 2004
    ..Finally, the RNA binding and splicing functions of the naturase domain of the intron-encoded protein will be studied. ..
  47. CHRONIC ALCOHOLISM AND LIVER ENERGY AND LIPID METABOLISM
    Carol Cunningham; Fiscal Year: 2004
    ..Phosphorus NMR spectroscopy will be utilized heavily in these latter studies. ..
  48. FREE RADICALS AND MUSCLE DYSFUNCTION IN HEART FAILURE
    GERALD SUPINSKI; Fiscal Year: 2005
    ..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of heart failure-related skeletal muscle dysfunction. ..
  49. 2 & 3D Imaging of Contrast Agents in Animal Models
    Britton Chance; Fiscal Year: 2004
    ..abstract_text> ..
  50. Images of Quantified Hypoxic Stress in Muscle
    Britton Chance; Fiscal Year: 2005
    ..Our especial goals are improving geriatric performance and detecting mitochondrial disease. See Appendix A for Glossary. ..
  51. Cytochrome Oxidase Polymorphisms in Aging
    Russell Swerdlow; Fiscal Year: 2007
    ..This work could help explain why complex genetic diseases are sometimes associated with mitochondrial dysfunction. ..
  52. OXIDATIVE PHOSPHORYLATION IN CELL GROWTH AND DEATH
    CARLOS TORRES MORAES; Fiscal Year: 2010
    ..abstract_text> ..
  53. ANTERO POSTERIOR PATTERN FORMATION IN C ELEGANS
    Cynthia Kenyon; Fiscal Year: 2001
    ..Together these studies should help to define the molecular mechanisms that regulate and execute these migrations. ..
  54. Ethanol effects on liver in self-administering primates
    Carol Cunningham; Fiscal Year: 2004
    ..fascicularis will develop liver pathology past the fatty liver stage and 2) to evaluate the efficacy of using blood and urine samples to follow development of alcoholic liver disease in an animal model. ..
  55. Microarrays for Alzheimer's Disease Mouse Models
    P Reddy; Fiscal Year: 2003
    ..The outcome of this proposed investigation will be useful in screening several mitochondrial antioxidants in AD transgenic mouse models as pre-clinical trials of AD patients...
  56. FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (fNIRI)
    Britton Chance; Fiscal Year: 2005
    ..These projects represent logical continuations of current activities into new and related researches. ..
  57. CONTROL OF ENZYMATIC PHOSPHATE TRANSFER IN MITOCHONDRIA
    Peter Pedersen; Fiscal Year: 2009
    ..These studies also have direct relevance to using nanotechnology in medicine as the ATP synthasome is comprised of 2 reversible nanomotors. ..
  58. CYTOCHROME OXIDASE ASSEMBLY GENES IN HUMAN DISEASE
    ERIC SCHON; Fiscal Year: 2003
    ..abstract_text> ..
  59. Neuroprotection After Cardiac Arrest
    Gary Fiskum; Fiscal Year: 2006
    ..S. alone, and over half of these suffering from neurological morbidity and mortality, the potential impact of the proposed translational research project is highly significant. ..
  60. Antioxidants and oxidative damage in mitochondria
    Cecilia Giulivi; Fiscal Year: 2004
    ..Structure-activity association of naturally occurring flavonoids in the abrogation of protein nitration, and 4. Bioavailability of flavonoids containing diets in nitrative stress. ..
  61. Phenotype MicroArrays for Drug Toxicity Screening
    Barry Bochner; Fiscal Year: 2007
    ....
  62. REGULATION OF C1 METABOLISM IN METHYLOTROPHS
    Mary Lidstrom; Fiscal Year: 2007
    ..abstract_text> ..
  63. GENETIC ANALYSIS OF AGING IN C ELEGANS
    Cynthia Kenyon; Fiscal Year: 2003
    ..Understanding this pathway in detail will ultimately answer the two most important questions in the aging field: how the aging process itself takes place, and how it can be regulated by endocrine signaling. ..
  64. PHYSIOLOGY OF RESPIRATORY MUSCLE CELLS
    Michael Reid; Fiscal Year: 2005
    ..Results of the proposed studies will help establish molecular mechanisms whereby TNFalpha stimulates catabolism of respiratory and limb skeletal muscle. ..