Genomes and Genes
Summary: The metabolic process of all living cells (animal and plant) in which oxygen is used to provide a source of energy for the cell.
Publications263 found, 100 shown here
- Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex IM Y El-Mir
Laboratoire de Bioénergétique Fondamentale et Appliquée, Universite Joseph Fourier, F 38041 Grenoble Cedex 09, France
J Biol Chem 275:223-8. 2000....
- HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cellsRyo Fukuda
Vascular Biology Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Cell 129:111-22. 2007..Thus, mammalian cells respond to hypoxia by altering COX subunit composition, as previously observed in yeast, but by a completely different molecular mechanism...
- MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptakeFabiana Perocchi
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Nature 467:291-6. 2010..Its discovery may lead to the complete molecular characterization of mitochondrial calcium uptake pathways, and offers genetic strategies for understanding their contribution to normal physiology and disease...
- Respiratory active mitochondrial supercomplexesRebeca Acín-Pérez
Departamento de Bioquimica, Universidad de Zaragoza, Miguel Servet, 177, 50013 Zaragoza, Spain
Mol Cell 32:529-39. 2008..Therefore, we have demonstrated the existence of a functional respirasome and propose a structural organization model that accommodates these findings...
- Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxiaRui Hua Xu
Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Res 65:613-21. 2005..Because the Warburg effect and hypoxia are frequently seen in human cancers, these findings may have broad clinical implications...
- Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respirationTatiana K Rostovtseva
Laboratory of Physical and Structural Biology, Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 105:18746-51. 2008..Additionally, tubulins that have lost significant length or anionic character are only found in cells that do not have mitochondria...
- NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respirationClaudio Mauro
Section of Inflammation and Signal Transduction, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK
Nat Cell Biol 13:1272-9. 2011..Our findings identify NF-κB as a physiological regulator of mitochondrial respiration and establish a role for NF-κB in metabolic adaptation in normal cells and cancer...
- Investigation of mitochondrial dysfunction by sequential microplate-based respiration measurements from intact and permeabilized neuronsPascaline Clerc
Department of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, Maryland, United States of America
PLoS ONE 7:e34465. 2012..Sequential measurements of intact and permeabilized cell respiration should be particularly useful for evaluating indirect mitochondrial toxicity due to drugs or cellular ..
- Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen speciesBrian P Dranka
Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, 35294, USA
Free Radic Biol Med 48:905-14. 2010..These data are consistent with a critical role for the mitochondrial reserve capacity in endothelial cells in responding to oxidative stress...
- Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transportAlisdair R Fernie
Department of Lothar Willmitzer, Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Golm, Germany
Curr Opin Plant Biol 7:254-61. 2004..Recently, a wide range of molecular and biochemical strategies have been adopted to elucidate the functional significance of these interactions...
- Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the SirtuinsDaniel L Smith
Department of Biochemistry and Molecular Genetics, University of Virginia Health System, School of Medicine, Charlottesville, VA 22908, USA
Aging Cell 6:649-62. 2007....
- Regulation of mitochondrial structure and function by the F1Fo-ATPase inhibitor protein, IF1Michelangelo Campanella
Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
Cell Metab 8:13-25. 2008..Thus, IF(1) regulates mitochondrial function and structure under both physiological and pathological conditions...
- Thioredoxin 2 haploinsufficiency in mice results in impaired mitochondrial function and increased oxidative stressViviana I Perez
The Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78229, USA
Free Radic Biol Med 44:882-92. 2008..Our results suggest that Txn2 plays an important role in protecting the mitochondria against oxidative stress and in sensitizing the cells to ROS-induced apoptosis...
- Human mitochondrial leucyl-tRNA synthetase corrects mitochondrial dysfunctions due to the tRNALeu(UUR) A3243G mutation, associated with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symptoms and diabetesRonghua Li
Division of Human Genetics, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
Mol Cell Biol 30:2147-54. 2010..These findings provide new insights into the molecular mechanism of maternally inherited diseases and a step toward therapeutic interventions for these disorders...
- Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondriaVamsi K Mootha
MDS Proteomics, Odense 5230, Denmark
Cell 115:629-40. 2003....
- Negative feedback maintenance of heme homeostasis by its receptor, Rev-erbalphaNan Wu
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Department of Genetics, and The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Genes Dev 23:2201-9. 2009..Thus, Rev-erbalpha modulates the synthesis of its own ligand in a negative feedback pathway that maintains heme levels and regulates cellular energy metabolism...
- Photon- and carbon-use efficiency in Ulva rigida at different CO2 and N levelsFrancisco J L Gordillo
Departamento de Ecologia, Facultad de Ciencias, Universidad de Malaga, Campus de Teatinos, 29071 Malaga, Spain
Planta 218:315-22. 2003....
- Thermal acclimation of leaf respiration but not photosynthesis in Populus deltoides x nigraLai Fern Ow
School of Biological Sciences, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
New Phytol 178:123-34. 2008..The R(d)/A(max) ratio declined at higher growth temperatures, and nitrogen status of leaves had little impact on the degree of acclimation...
- Rapid temperature acclimation of leaf respiration rates in Quercus alba and Quercus rubraPaul V Bostad
Department of Forest Resources, 115 Green Hall, University of Minnesota, 1530 Cleveland Ave N, St Paul, MN 55108, USA
Tree Physiol 23:969-76. 2003..Total nonstructural carbohydrate concentration was slightly, but statistically, lower (13.6 versus 12%, P<0.05) after a 10 degrees C increase in temperature...
- Biochemical characterization of the mitochondrial tRNASer(UCN) T7511C mutation associated with nonsyndromic deafnessXiaoming Li
Division and Program in Human Genetics and Center for Hearing and Deafness Research, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
Nucleic Acids Res 32:867-77. 2004..These observations imply that a combination of the T7511C mutation with two mtDNA mutations accounts for the high penetrance of deafness in this family...
- Cell respiration under hypoxia: facts and artefacts in mitochondrial oxygen kineticsFrancesca M Scandurra
Department of General and Transplant Surgery, D Swarovski Research Laboratory, Medical University of Innsbruck, Innsbruck, Austria
Adv Exp Med Biol 662:7-25. 2010..01 to 0.10 kPa in mitochondria and small cells in the absence of inhibitors of cytochrome c oxidase, whereas experimental artefacts explain the controversial >200-fold range of p (50) in the literature on mitochondrial oxygen kinetics...
- Lactic acidemia in the pathogenesis of mice carrying mitochondrial DNA with a deletionEmi Ogasawara
Graduate School of Life and Environmental Sciences, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, Ibaraki 305 8572, Japan
Hum Mol Genet 19:3179-89. 2010..Our in vivo study also suggested that inhibition of chronic lactic acidemia is a potential strategy for treating some mitochondrial diseases...
- Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytesBlake R Zelickson
Center for Free Radical Biology, University of Alabama at Birmingham, AL 35294, USA
Biochim Biophys Acta 1807:1573-82. 2011..These data support the concept that the combined effects of NO and ethanol contribute to an increased susceptibility to hypoxia and the deleterious effects of alcohol consumption on liver...
- Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replicationYuriy Shapovalov
The Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Biol Chem 286:22331-8. 2011..Our study provides insight into mechanisms of mitochondrial dysfunction in cancer and may offer potential therapeutic targets...
- Correction of the consequences of mitochondrial 3243A>G mutation in the MT-TL1 gene causing the MELAS syndrome by tRNA import into mitochondriaOlga Z Karicheva
UMR 7156 University of Strasbourg CNRS, Molecular Genetics, Genomics and Microbiology, Strasbourg 67084, France
Nucleic Acids Res 39:8173-86. 2011..These findings prove the possibility to direct tRNAs with changed aminoacylation specificities into mitochondria, thus extending the potential therapeutic strategy of allotopic expression to address mitochondrial disorders...
- Intracellular O2 sensing probe based on cell-penetrating phosphorescent nanoparticlesAndreas Fercher
Biochemistry Department, University College Cork, Cavanagh Building, College Road, Cork, Ireland
ACS Nano 5:5499-508. 2011..High brightness and photostability allow its use in screening experiments with cell populations on a commercial TR-F reader, and for single cell analysis on a fluorescent microscope...
- Gender dimorphism in rat liver mitochondrial oxidative metabolism and biogenesisRoberto Justo
Grup de Metabolisme Energetic i Nutricio, Departament de Biologia Fonamental i Ciencies de la Salut, Institut Universitari d Investigacio en Ciencies de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain
Am J Physiol Cell Physiol 289:C372-8. 2005....
- Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomyDaniela Valenti
Institute of Biomembranes and Bioenergetics, National Research Council CNR, Bari, Italy
Biochem J 431:299-310. 2010..These results provide new insight into the molecular basis for mitochondrial dysfunction in DS and might provide a molecular explanation for some clinical features of the syndrome...
- Cyclosporine A attenuates mitochondrial permeability transition and improves mitochondrial respiratory function in cardiomyocytes isolated from dogs with heart failureVictor G Sharov
Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute, Detroit, Michigan 48202, USA
J Mol Cell Cardiol 42:150-8. 2007..Attenuation of calcein exit, DeltaPsi(m) and improvement of state-3 respiration achieved with CsA (0.2 microM) show that permeability transition opening could be a cause of mitochondrial dysfunction described in the failing heart...
- Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stressTim J Schulz
Department of Human Nutrition, Institute of Nutrition, University of Jena, D 07743 Jena, Germany
Cell Metab 6:280-93. 2007....
- Evaluating a new method to estimate the rate of leaf respiration in the light by analysis of combined gas exchange and chlorophyll fluorescence measurementsXinyou Yin
Centre for Crop Systems Analysis, Department of Plant Sciences, Wageningen University, PO Box 430, 6700 AK Wageningen, The Netherlands
J Exp Bot 62:3489-99. 2011....
- Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supplyE Gnaiger
D Swarovski Research Laboratory, Department of Transplant Surgery, University Hospital Innsbruck, Anichstrasse 35, 6020, Innsbruck, Austria
Respir Physiol 128:277-97. 2001..Bioenergetics at low oxygen versus oxidative stress must be considered in the context of limitation of maximum aerobic activity, ischemia-reperfusion injury, mitochondrial signalling to apoptosis, and mitochondrial theories of ageing...
- Heterogeneity of the mitochondrial proteome for photosynthetic and non-photosynthetic Arabidopsis metabolismChun Pong Lee
Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, 35 Stirling Highway, Crawley 6009, Western Australia, Australia
Mol Cell Proteomics 7:1297-316. 2008....
- The basal proton conductance of mitochondria depends on adenine nucleotide translocase contentMartin D Brand
Medical Research Council Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
Biochem J 392:353-62. 2005..We conclude that half to two-thirds of the basal proton conductance of mitochondria is catalysed by the adenine nucleotide carrier, independently of its ATP/ADP exchange or fatty-acid-dependent proton-leak functions...
- Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin/peroxiredoxin systemDerek A Drechsel
Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, Colorado 80045, USA
J Biol Chem 285:27850-8. 2010..These findings implicate respiration- and thioredoxin-dependent ROS removal as a potentially important mitochondrial function that may contribute to physiological and pathological processes in the brain...
- Bioenergetic consequences of opening the ATP-sensitive K(+) channel of heart mitochondriaA J Kowaltowski
Department of Biochemistry and Molecular Biology, Oregon Graduate Institute of Science and Technology, Beaverton, Oregon 97006-8921, USA
Am J Physiol Heart Circ Physiol 280:H649-57. 2001..Thus opening mitochondrial K(ATP) channels has little direct effect on respiration, membrane potential, or Ca(2+) uptake but has important effects on matrix and intermembrane space volumes...
- Spare respiratory capacity, oxidative stress and excitotoxicityDavid G Nicholls
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Biochem Soc Trans 37:1385-8. 2009..Mitochondria play a central role in the survival or death of the exposed neuron. Calcium, oxidative stress and ATP insufficiency play closely interlocked roles that may be investigated with primary neuronal cultures...
- Global convergence in the temperature sensitivity of respiration at ecosystem levelMiguel D Mahecha
Max Planck Institute for Biogeochemistry, 07745 Jena, Germany
Science 329:838-40. 2010..The results may partly explain a less pronounced climate-carbon cycle feedback than suggested by current carbon cycle climate models...
- Fatty acids as modulators of the cellular production of reactive oxygen speciesPeter Schonfeld
Institute of Biochemistry and Cell Biology, Otto von Guericke University, Leipziger Str 44, 39120 Magdeburg, Germany
Free Radic Biol Med 45:231-41. 2008..These effects of FFA can modulate signaling functions of ROS and be, at least partly, responsible for their proapoptotic effects in several types of cells...
- Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenoneNagendra Yadava
Buck Institute for Age Research, Novato, California 94945, USA
J Neurosci 27:7310-7. 2007..The bioenergetic consequences of rotenone addition were quantified by monitoring cell respiration. Glutamate activation of NMDA receptors used the full respiratory capacity of the in situ mitochondria, and >..
- Mitochondrial energy metabolism is regulated via nuclear-coded subunits of cytochrome c oxidaseB Kadenbach
Fachbereich Chemie, Philipps Universitat, Marburg, Germany
Free Radic Biol Med 29:211-21. 2000..High substrate pressure (sigmoidal v/s kinetics), palmitate and 3,5-diiodothyronine (binding to subunit Va) increase also delta p, ROS production and slip but without dephosphorylation of COX...
- Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesisJ J Lehman
Department of Medicine, and Department of Pathology, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 106:847-56. 2000..These results identify PGC-1 as a critical regulatory molecule in the control of cardiac mitochondrial number and function in response to energy demands...
- Butyrate metabolism upstream and downstream acetyl-CoA synthesis and growth control of human colon carcinoma cellsX Leschelle
Laboratoire de Nutrition et Securite Alimentaire, Institut National de la Recherche Agronomique, Jouy en Josas, France
Eur J Biochem 267:6435-42. 2000..In contrast, the metabolism downstream of acetyl-CoA [i.e. oxidation in the tricarboxylic acid (TCA) cycle and lipid synthesis] likely acts as a regulator of butyrate intracellular concentration...
- Mitochondrial K(ATP) channels in cell survival and deathHossein Ardehali
Institute of Molecular Cardiobiology, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205 2195, USA
J Mol Cell Cardiol 39:7-16. 2005..In this review, we attempt to highlight the recent advances in the physiological role of mitoK(ATP) and discuss the controversies and unanswered questions...
- Functional delivery of a cytosolic tRNA into mutant mitochondria of human cellsBidesh Mahata
Genetic Engineering, Indian Institute of Chemical Biology, 4 Raja S C Mullick Road, Calcutta 700032, India
Science 314:471-4. 2006..The use of protein complexes to modulate mitochondrial function may help in the management of such genetic disorders...
- Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1P Puigserver
Dana Farber Cancer Institute, Department of Cell Biology, Boston, MA 02115, USA
Mol Cell 8:971-82. 2001..These data illustrate a direct thermogenic action of cytokines and p38 MAP kinase through the transcriptional coactivator PGC-1...
- Analysis of intracellular oxygen and metabolic responses of mammalian cells by time-resolved fluorometryAlexander V Zhdanov
Luxcel Biosciences Ltd, BioInnovation Centre, UCC, Cork, Ireland
Anal Chem 79:9414-9. 2007..The assay provides relevant, information-rich data on cellular function and metabolism. It allows monitoring of small, rapid, and transient changes in cell respiration and screening of new chemical entities.
- Mitochondrial dysfunction and oxidative damage in parkin-deficient miceJames J Palacino
Center for Neurologic Diseases, Brigham and Women s Hospital, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 279:18614-22. 2004....
- Cytochrome c oxidase maintains mitochondrial respiration during partial inhibition by nitric oxideMiriam Palacios-Callender
Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK
J Cell Sci 120:160-5. 2007..of mitochondrial cytochrome c oxidase (CcO) at O2 concentrations ([O2]) above those at which it inhibits cell respiration. Thus, in cells respiring to anoxia, the addition of 2...
- Interactive effects of temperature and precipitation on soil respiration in a temperate maritime pine forestJ Curiel Yuste
University of Antwerpen, Department of Biology, Research Group of Plant and Vegetation Ecology, Universiteitsplein 1, B 2610 Wilrijk, Belgium
Tree Physiol 23:1263-70. 2003..Our results revealed that, in addition to temperature and SWC, rain plays a role in determining the total amount of carbon released from soils, even in a maritime climate...
- Endothelial mitochondria--less respiration, more integrationLukas N Groschner
Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Harrachgasse 21 III, 8010, Graz, Austria
Pflugers Arch 464:63-76. 2012..In this review, we want to outline the significance of mitochondria in both physiology and pathology of the vascular endothelium...
- The mystery of reactive oxygen species derived from cell respirationHans Nohl
Basic Research in Pharmacology and Toxicology, University of Veterinary Medicine Vienna, Vienna, Austria
Acta Biochim Pol 51:223-9. 2004..However, changing the physical membrane state affected the highly susceptible interaction of the ubiquinol/bc(1) redox complex such that ROS formation became possible...
- SIRT3, a mitochondrial sirtuin deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytesTong Shi
United States Department of Agriculture Agricultural Research Service Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA
J Biol Chem 280:13560-7. 2005..In summary, our results demonstrate that SIRT3 activates mitochondria functions and plays an important role in adaptive thermogenesis in brown adipose...
- Increased potassium conductance of brain mitochondria induces resistance to permeability transition by enhancing matrix volumeMagnus J Hansson
Mitochondrial Pathophysiology Unit, Laboratory for Experimental Brain Research, Department of Clinical Sciences, Lund University, SE 221 84 Lund, Sweden
J Biol Chem 285:741-50. 2010..We propose that increased potassium conductance in brain mitochondria may cause a direct physiological effect on matrix volume inducing resistance to pathological calcium challenges...
- Function of mitochondrial Stat3 in cellular respirationJoanna Wegrzyn
Department of Biochemistry and Molecular Biology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA
Science 323:793-7. 2009..These data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis...
- Genotype effects on internal gas gradients in apple fruitQ Tri Ho
Flanders Centre of Postharvest Technology BIOSYST MeBioS, Faculty of Bioscience Engineering, Katholieke Universiteit Leuven, Willem de Croylaan 42, Leuven, Belgium
J Exp Bot 61:2745-55. 2010..Kanzi had less O(2) anoxia at CA storage compared with Braeburn...
- Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress responseN Moisoi
Cell Death Regulation Laboratory, MRC Toxicology Unit, Leicester LE1 9HN, UK
Cell Death Differ 16:449-64. 2009..We therefore propose that this brain-specific transcriptional response to stress may be important in the advance of neurodegenerative diseases...
- Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F₁F0-ATP synthaseMarie Bergeaud
Laboratoire de génétique et biologie cellulaire LGBC Université de Versailles St Quentin en Yvelines Ecole Pratique des Hautes Etudes UFR des Sciences de la Santé Montigny le Bretonneux, France
Cell Cycle 12:2781-93. 2013....
- Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxinRavindar R Thomas
Morris Udall Parkinson s Disease Research Center of Excellence, University of Virginia, Charlottesville, VA, United States
Mitochondrion 11:108-18. 2011..rhTFAM treatment improved motor recovery rate after treatment with MPTP and dose-dependently improved survival in the lipopolysaccharide model of endotoxin sepsis...
- Meclizine is neuroprotective in models of Huntington's diseaseVishal M Gohil
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
Hum Mol Genet 20:294-300. 2011..Since meclizine is an approved drug that crosses the blood-brain barrier, it may hold therapeutic potential in the treatment of polyQ toxicity disorders, such as Huntington's disease...
- Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell linesTherese Bredholt
The Gade Institute, University of Bergen, Bergen, Norway
Mol Cancer 8:101. 2009..The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with khat in a panel of acute myeloid leukemia cell lines to elucidate mechanisms of toxicity...
- The carbon monoxide-releasing molecule, CORM-3 (RU(CO)(3) CL(glycinate)), targets respiration and oxidases in Campylobacter jejuni, generating hydrogen peroxideHolly Smith
Department of Molecular Biology and Biotechnology, University of Sheffield, UK
IUBMB Life 63:363-71. 2011..This work shows that CO-RMs have valuable properties as antimicrobial agents; however, growth inhibition does not always accompany inhibition of respiration, even when ambient oxygen concentrations are low...
- The ADP and ATP transport in mitochondria and its carrierMartin Klingenberg
Institut Physiologische Chemie der Universität München, Germany
Biochim Biophys Acta 1778:1978-2021. 2008..Being a snapshot of an extreme abortive "c-state" the actual mechanism still remains a conjecture...
- Inter-connection between mitochondria and HIFsKathryn V Tormos
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 2909, USA
J Cell Mol Med 14:795-804. 2010..In this review, we examine the evidence that mitochondria and HIFs are intimately connected to regulate each other resulting in appropriate responses to hypoxia...
- Cryopreservation of mitochondria and mitochondrial function in cardiac and skeletal muscle fibersAndrey V Kuznetsov
Department of Transplant Surgery, University Hospital Innsbruck, Austria
Anal Biochem 319:296-303. 2003..This will significantly expand the scope for screening and exchange of human biopsy samples between research centers, thus providing a new basis for functional analysis of mitochondrial defects in various diseases...
- Nuclear background determines biochemical phenotype in the deafness-associated mitochondrial 12S rRNA mutationM X Guan
Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
Hum Mol Genet 10:573-80. 2001....
- Regulation of cytochrome c oxidase activity by c-Src in osteoclastsTsuyoshi Miyazaki
Department of Cell Biology, Yale University School of Medicine, PO Box 208044, New Haven, CT 06520 8044, USA
J Cell Biol 160:709-18. 2003..These results suggest that c-Src plays a previously unrecognized role in maintaining cellular energy stores by activating Cox in mitochondria...
- Respiratory chain supercomplexesH Schagger
Zentrum der Biologischen Chemie, Universitatsklinikum Frankfurt, Frankfurt am Main, Germany
IUBMB Life 52:119-28. 2001..Dimeric ATP synthase seems to be specific for mitochondrial OXPHOS systems. Monomeric complex V was found in Acetobacterium woodii and Paracoccus denitrificans...
- Endothelial cell respiration is affected by the oxygen tension during shear exposure: role of mitochondrial peroxynitriteCharles I Jones
Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
Am J Physiol Cell Physiol 295:C180-91. 2008..Hence, the hyperoxia of in vitro EC flow studies, via increased NO and mitochondrial O(2)(*-) production, leads to enhanced ONOO(-) formation intramitochondrially and suppression of respiration...
- Imaging of oxygen gradients in monolayer cultured cells using green fluorescent proteinEiji Takahashi
Biomedical Engineering Course, Advanced Technology Fusion, Graduate School of Science and Engineering, Saga Univ, Saga 840 8502, Japan
Am J Physiol Cell Physiol 299:C1318-23. 2010..Findings in the present two-dimensional O(2) diffusion model support the crucial role of tissue O(2) diffusion in defining the O(2) microenvironment in individual cells...
- H2O2-induced mitochondrial fragmentation in C2C12 myocytesXiying Fan
Department of Integrative Biology, University of California, Berkeley, CA 94720 3140, USA
Free Radic Biol Med 49:1646-54. 2010..Because H(2)O(2) is produced in contracting muscle, our results raise the possibility that ROS generation may contribute to exercise-induced changes in mitochondrial morphology in vivo...
- A Clark-type oxygen chip for in situ estimation of the respiratory activity of adhering cellsChing Chou Wu
Department of Bio Industrial Mechatronics Engineering, National Chung Hsing University, No 250, Kuo Kuang Road, Taichung 402, Taiwan
Talanta 81:228-34. 2010..Moreover, the change in the respiration activity of adhering HeLa cells stimulated by the high concentration of glucose or propofol anaesthetic can be monitored in real time with the Clark-type oxygen chip...
- Huperzine A protects isolated rat brain mitochondria against beta-amyloid peptideXin Gao
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi Tech Park, Shanghai 201203, People s Republic of China
Free Radic Biol Med 46:1454-62. 2009..These direct effects on mitochondria further extend the noncholinergic functions of HupA...
- Inhibitory effects of Bcl-2 on mitochondrial respirationM Vrbacky
Department of Immunology and Microbiology, First Faculty of Medicine of Charles University, Studnickova 7, 128 00 Prague 2, Czech Republic
Physiol Res 52:545-54. 2003..Based on this observation, we propose that the outcome of Bcl-2 expression is determined by the type of cellular ATP synthesis, namely that Bcl-2 causes apoptosis in cells relying on oxidative phosphorylation...
- The diel imprint of leaf metabolism on the δ13 C signal of soil respiration under control and drought conditionsMatthias Barthel
Institute of Agricultural Sciences, ETH Zurich, Universitatsstrasse 2, 8092 Zurich, Switzerland
New Phytol 192:925-38. 2011..2.5, depending on the photosynthetic rate. Drought slows the coupling between photosynthesis and soil respiration and alters the underlying mechanism causing diel variations of δ(13) C(SR)...
- Esterified trityl radicals as intracellular oxygen probesYangping Liu
Center for Biomedical EPR Spectroscopy and Imaging, The Davis Heart and Lung Research Institute, Division of Cardiovascular Medicine, Department of Internal Medicine, Columbus, OH 43210, USA
Free Radic Biol Med 46:876-83. 2009..This study demonstrates that these esterified trityl radicals can function as effective EPR oximetry probes measuring intracellular O2 concentration and consumption...
- Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondriaAlexander V Zhdanov
Biochemistry Department, University College Cork, Cavanagh Pharmacy Building, College Road, Cork, Republic of Ireland
Cell Mol Life Sci 68:903-17. 2011..Cells treated with Baf become more susceptible to excitation with KCl. Such mitochondrial uncoupling may play a role in a number of (patho)physiological conditions induced by Baf...
- Melatonin reduces oxidant damage and promotes mitochondrial respiration: implications for agingRussel J Reiter
Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
Ann N Y Acad Sci 959:238-50. 2002..As of this writing there is no definitive evidence to prove that melatonin alters the rate of aging, although data relating to melatonin deferring some age-related degenerative conditions is accumulating rapidly...
- Starch synthesis and carbon partitioning in developing endospermM J Emes
School of Biological Sciences, University of Manchester, 3 614 Stopford Building, Manchester M13 9PT, UK
J Exp Bot 54:569-75. 2003..As ADPG is an activated sugar, the dependence of its production on respiration, changes which occur during development, and the constraints which ATP production may place on carbon partitioning into different end-products are discussed...
- The neuromediator glutamate, through specific substrate interactions, enhances mitochondrial ATP production and reactive oxygen species generation in nonsynaptic brain mitochondriaAlexander Panov
Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA
J Biol Chem 284:14448-56. 2009....
- Toll-like receptor-3-induced mitochondrial dysfunction in cultured human hepatocytesSiamak Djafarzadeh
Department of Intensive Care Medicine, Inselspital, Bern University Hospital and University of Bern, 3010 Bern, Switzerland
Mitochondrion 11:83-8. 2011..Poly-I:C induced activation of NF-κB, and the mitochondrial dysfunction was accompanied by caspase-8 but not caspase-3 activation and by no major alterations in cellular or mitochondrial ultrastructure...
- Effect of amyloid beta-peptide on permeability transition pore: a comparative studyPaula I Moreira
Department of Zoology, University of Coimbra, Coimbra, Portugal
J Neurosci Res 69:257-67. 2002..It can be concluded that brain and liver mitochondria show a different susceptibility to the deleterious effect of A beta peptide, brain mitochondria being more resistant to the potentiation by A beta of Ca(2+)-induced PTP...
- Adaptation of microplate-based respirometry for hippocampal slices and analysis of respiratory capacityRosemary A Schuh
Research Service, Maryland VA Healthcare System, Baltimore, Maryland, USA
J Neurosci Res 89:1979-88. 2011..When coupled with cell type-specific pharmacology or genetic manipulations, the ability to measure O(2) consumption efficiently from whole slices should advance our understanding of mitochondrial roles in physiology and neuropathology...
- nMAT1, a nuclear-encoded maturase involved in the trans-splicing of nad1 intron 1, is essential for mitochondrial complex I assembly and functionIdo Keren
Institute of Plant Sciences, Agricultural Research Organizaion, Volcani Center, Bet Dagan 50250, Israel
Plant J 71:413-26. 2012..Homozygous nMat1 plants show retarded growth and developmental phenotypes, modified respiration activities and altered stress responses that are tightly correlated with mitochondrial complex I defects...
- Mitochondrial DNA background modifies the bioenergetics of NARP/MILS ATP6 mutant cellsM D'Aurelio
Weill Medical College of Cornell University, New York, NY 10065, USA
Hum Mol Genet 19:374-86. 2010..Taken together, these results indicate that the mtDNA background plays an important role in modulating the biochemical defects and clinical outcome in NARP/MILS...
- Inhibition of mitochondrial respiration and rapid depletion of mitochondrial glutathione by β-phenethyl isothiocyanate: mechanisms for anti-leukemia activityGang Chen
Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Antioxid Redox Signal 15:2911-21. 2011..This study aimed at investigating the key mechanisms that contribute to the potent anti-leukemia activity of PEITC and at evaluating its therapeutic potential...
- Respiration and photosynthesis of bladders and leaves of aquatic utricularia speciesL Adamec
Institute of Botany of the Academy of Sciences of the Czech Republic, Section of Plant Ecology, Dukelska 135, 379 82 Trebon, Czech Republic
Plant Biol (Stuttg) 8:765-9. 2006....
- The effect of different ubiquinones on lifespan in Caenorhabditis elegansYu Ying Yang
Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
Mech Ageing Dev 130:370-6. 2009..Moreover, when compared to other dietary quinones, UQ(10) further decreased mitochondrial oxidative damage and extended adult lifespan in clk-1...
- Effects of drought stress and subsequent rewatering on photosynthetic and respiratory pathways in Nicotiana sylvestris wild type and the mitochondrial complex I-deficient CMSII mutantAlexander Galle
Grup de Recerca en Biologia de les Plantes en Condicions Mediterranies, Departament de Biologia UIB IMEDEA, Universitat de les Illes Balears, Carretera de Valldemossa Km 7 5, E 07122 Palma de Mallorca, Spain
J Exp Bot 61:765-75. 2010....
- Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor propertiesRiccardo Rubbiani
Institute of Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig, Germany
J Med Chem 53:8608-18. 2010....
- Oxidative metabolism in cancer growthMichael Ristow
Department of Human Nutrition, Institute of Nutrition, University of Jena, Jena, Germany
Curr Opin Clin Nutr Metab Care 9:339-45. 2006....
- Temporal increase of platelet mitochondrial respiration is negatively associated with clinical outcome in patients with sepsisFredrik Sjövall
Mitochondrial Pathophysiology Unit, Laboratory for Experimental Brain Research, Department of Clinical Sciences, Lund University, Solvegatan 17, SE 221 84, Lund, Sweden
Crit Care 14:R214. 2010..Here we investigated temporal changes in platelet mitochondrial respiratory function in patients with sepsis during the first week after disease onset...
- Biochemical assays of respiratory chain complex activityDenise M Kirby
Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, Framlington Place, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom
Methods Cell Biol 80:93-119. 2007
- Evidence of mitochondrial involvement in the transduction of signals required for the induction of genes associated with pathogen attack and senescenceDenis P Maxwell
Michigan State University Department of Energy Plant Research Laboratory, Michigan State University, East Lansing 48824, USA
Plant J 29:269-79. 2002..These findings suggest that the mitochondrion may serve an important role in conveying intracellular stress signals to the nucleus, leading to alterations in gene expression...
- Genetic modification of alternative respiration has differential effects on antimycin A-induced versus salicylic acid-induced resistance to Tobacco mosaic virusAndroulla Gilliland
Department of Plant Sciences, University of Cambridge, Cambridge CB2 3EA, United Kingdom
Plant Physiol 132:1518-28. 2003..Other antiviral factors, potentially including the SA-inducible RNA-dependent RNA polymerase, are regulated by AOX-independent mechanisms...
- The pervasive presence of fluctuating oxygenation in tumorsLaura I Cárdenas-Navia
Department of Biomedical Engineering, Duke University, Durham, North Carolina, USA
Cancer Res 68:5812-9. 2008..The widespread presence of fluctuations in tumor oxygenation has broad ranging implications for tumor progression, stress response, and signal transduction, which are altered by oxygenation/reoxygenation events...
- Mitochondrial oxygen affinity, respiratory flux control and excess capacity of cytochrome c oxidaseE Gnaiger
Department of Transplant Surgery, D Swarovski Research Laboratory, University Hospital Innsbruck, Innsbruck, Austria
J Exp Biol 201:1129-39. 1998..Accordingly, enzymatic capacities are matched in terms of optimum ratios, rather than equal levels, to meet the specific kinetic and thermodynamic demands set by the low-oxygen environment in the cell...
- Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respirationSu Ju Lin
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nature 418:344-8. 2002..We discuss how this metabolic strategy may apply to CR in animals...
- Nitroxia: the pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathwaySruti Shiva
Department of Pathology, University of Alabama at Birmingham, BMR II, 901 19th Street South, Birmingham, AL 35294, USA
Free Radic Biol Med 38:297-306. 2005..We term this unique pathological condition Nitroxia and describe how it may contribute to the pathology of chronic inflammatory diseases using ethanol-dependent hepatotoxicity as an example...
- Influence of chloroplastic photo-oxidative stress on mitochondrial alternative oxidase capacity and respiratory properties: a case study with Arabidopsis yellow variegated 2Keisuke Yoshida
Department of Biological Sciences, Graduate School of Science, Osaka University, 1 1 Machikaneyama cho, Toyonaka, Osaka 560 0043, Japan
Plant Cell Physiol 49:592-603. 2008..These results indicate that photo-oxidative stress by excess light is involved in the regulation of respiratory gene expression and the modulation of respiratory properties, especially the AOX up-regulation...
- A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegansDavid Cristina
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
PLoS Genet 5:e1000450. 2009..Loss of fstr-1/2 does not suppress the phenotypes of all long-lived mitochondrial mutants. Thus, although different mitochondrial perturbations activate similar transcriptional and physiological responses, they do so in different ways...
- MECHANISM OF RESPIRATION AND ENERGY TRANSDUCTIONBernard Trumpower; Fiscal Year: 2009The cytochrome bc1 complex is an energy-transducing enzyme that participates in cell respiration in oxygen utilizing eukaryotic cells and is located in the inner mitochondrial membrane...
- ELECTRON PARAMAGNETIC RESONANCE SPECTROMETERCecilia Giulivi; Fiscal Year: 2009..in the ryanodine receptor type 1;d) nitric oxide as an important modulator of cell respiration and mediator of oxygen gradient redistribution;e) reactive oxygen and nitrogen radicals during caloric ..
- Novel Hydrogen Sulfide Sensors for Portable MonitorsStephen Williams; Fiscal Year: 2004..is a colorless, flammable gas that is highly toxic It reacts with the enzymes in the blood that inhibit cell respiration At high concentrations, it can literally shut off the lungs, while lower levels can burn the respiratory ..
- Mechanoregulation of endothelial mitochondrial functionBARBARA ALEVRIADOU; Fiscal Year: 2009..its interaction with electron transport chain (ETC) components, may function not only as a regulator of cell respiration, but also to augment the generation of reactive oxygen species (ROS) by mitochondria and thereby trigger ..
- Mechanisms of Nitric Oxide Mediated Cell InjuryDAVID JOURD HEUIL; Fiscal Year: 2005..We propose that S-nitrosation reactions contribute to the inhibition of cell respiration and proliferation that is associated with increased NO production...
- OSTEOARTHRITIS/CHONDROCALCINOSIS: MITOCHONDRIAL THERAPYAnne Murphy; Fiscal Year: 2003..Importantly, the lead compounds effectively block trigger-induced ATP depletion and inhibition of intact cell respiration. Specific Aim 1 will test whether the efficacy of specific lead compounds is primarily due to direct ..
- CONTINUOUS-FLOW SYSTEM FOR HYBRIDOMA MICROENCAPSULATIONHARRIS GOLD; Fiscal Year: 1990..barrier is how to provide scale-up production of small alginate gel balls, which are necessary to support cell respiration. The objectives of the proposed Phase II program are 91) to develop a full-scale prototype of a process for ..
- SYNTHESIS OF SELECTIVE DEHYDROGENASE INHIBITORSEUGENE COATS; Fiscal Year: 1980..The results of these studies will be utilized in the design of selective inhibitors of anaerobic and aerobic tumor cell respiration as potential antineoplastic agents.
- Mitochondrial Dysfunction in Aged MuscleDavid J Marcinek; Fiscal Year: 2010Mitochondria play a key role in linking cell respiration to cell survival and are critical elements in many age- related degenerative pathologies: The mitochondrial theory of aging proposes that oxidative damage leads to irreversible ..
- Mitochondrial control of neuronal excitotoxicityDavid Nicholls; Fiscal Year: 2005..4. To test the hypothesis that mitochondria at specific intracellular locations may be selectively vulnerable to glutamate excitotoxicity because of their proximity to NMDA receptors, or their location in regions of high-energy demand. ..
- EXPRESSION OF HUMAN ERYTHROPOIETIN GENEGregg Semenza; Fiscal Year: 2002..abstract_text> ..
- Hypoxia-Inducible Factor 1 and Oxygen HomeostasisGregg Semenza; Fiscal Year: 2009....
- Aging-Related Models and Mitochondrial BioenergeticsDavid Nicholls; Fiscal Year: 2006..3. To indicate therapeutic strategies whereby the deleterious consequences of aging-related changes in mitochondrial function can be minimized. ..
- Control of ATP Producing Pathways in Skeletal MuscleBrandon Walsh; Fiscal Year: 2005..determine the role of metabolic channeling in setting the onset kinetics of oxidative phosphorylation, and 3.) determine the intracellular PO2 at which respiration becomes O2 dependent. ..
- RESPIRATION AND GLYCOLYSIS--INTEGRATION IN ACTIVE MUSCLEKevin Conley; Fiscal Year: 2002..g., diabetes. An understanding of the integration of metabolism in healthy tissue is the first step to understanding how failure of integration limits function in diseased muscle. ..
- Creatine Transport Across the Blood Brain BarrierJoseph Clark; Fiscal Year: 2006..The goal for Hypothesis 2 is to develop methods and drugs to improve brain energy metabolism by getting creatine into the brain. ..
- Induction of Inflammation by Mitochondrial ProteinsElliott Crouser; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- PHYSIOLOGY OF THE RESPIRATORY MUSCLESMichael Reid; Fiscal Year: 2006..Aim 2. To determine the molecular source(s) and distribution of muscle-derived NO. Aim3. To evaluate principal source(s) of intracellular ROS and mechanisms that regulate ROS activity. ..
- Detection of Bioterrorism Agents with PM TechnologyBarry Bochner; Fiscal Year: 2006..abstract_text> ..
- XIIIth Biennial Meeting of the Society for Free Radical Research InternationalEnrique Cadenas; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- REGULATION OF MITOCHONDRIAL BIOGENESIS IN YEASTRONALD BUTOW; Fiscal Year: 2007..These experiments should[unreadable] provide additional insights into the function of retrograde regulation.[unreadable]..
- MSM Multiscale Modeling of the Heart in CardiovascularDANIEL BEARD; Fiscal Year: 2007..abstract_text> ..
- Human mitochondrial fatty acid synthaseStuart Smith; Fiscal Year: 2009..Elucidation of the role of the mitFAS system in mitochondrial function may aid in understanding the etiology of these disorders. ..
- Integrated Metabolism in Methylobacterium extroquens AM1Mary E Lidstrom; Fiscal Year: 2010..This study is expected to result in new principles in metabolic integration, as well new insights into C1 metabolism. ..
- GM-CSF responsiveness in alcohol-mediated lung injuryDavid Guidot; Fiscal Year: 2009..The ultimate goal of this project is to develop human recombinant GM-CSF as a therapy for patients at high risk for acute lung injury as a consequence of chronic alcohol abuse. ..
- Oxidative Stress, Mitochondrial Dysfunction and AgingEnrique Cadenas; Fiscal Year: 2009..These mechanisms play a critical role in the progression of the aging process and may precede or modulate age-related oxidative- and nitrosative damages. ..
- Mitochondria and Cerebral ischemia: intracellular signalingMiguel Perez Pinzon; Fiscal Year: 2009....
- Bilirubin oxidation and intracerebral hemorrhageJoseph Clark; Fiscal Year: 2009..These studies are important because we believe that strategies designed to prevent BOXes production in the hematoma should provide a novel and beneficial therapeutic option for patients who have suffered an ICH. ..
- STRUCTURE AND SPECIFICITY OF LIPOGENIC ENZYMESStuart Smith; Fiscal Year: 2008..abstract_text> ..
- HIV-1 and ethanol-induced alveolar epithelial and macrophage dysfunctionDavid Guidot; Fiscal Year: 2007..Ultimately, the long-term goal of this project is to identify effective new adjunctive therapies that can complement standard treatment and enhance lung function in HIV-1-infected individuals. [unreadable] [unreadable] [unreadable]..
- The Pathogenesis and Genetics of Environmental AsthmaJONATHAN STAMLER; Fiscal Year: 2007..In aggregate, the coupled scientific findings in this program will substantially enhance our understanding of the pathogenesis and genetics of asthma. ..
- Uncoupling Proteins and Species-Dependent LongevityTamas Horvath; Fiscal Year: 2007..Our attempts to provide comparative analyses of age related molecular mechanisms in rodents and nonhuman primates, will provide novel therapeutic targets, UCPs, to increase longevity without compromising tissue function. ..
- Uncoupling Protein 2 Promotes Neuronal SurvivalTamas Horvath; Fiscal Year: 2006..This will furnish one common target for the development of drugs against a variety of neurodegenerative pathologies, including those associated with hypoxia, epilepsy, Parkinson's, Alzheimer's and Huntington's Disease. ..
- Ocular HSV-1: Chromatin Remodeling in Latent TGDONNA NEUMANN; Fiscal Year: 2006..unreadable] [unreadable]..
- Oxidants, Mitochondria,and Renal Ischemia/ReperfusionLEE MACMILLAN CROW; Fiscal Year: 2005..This information will be helpful in determining possible therapeutic interventions for improving current techniques in renal preservation and transplantation. ..
- MITOCHONDRIAL CYTOCHROME C RELEASE VIA MEMBRANE PORESElliott Crouser; Fiscal Year: 2004..These advisors are actively investigating the role mitochondria in the pathogenesis of disease. Thus, the prospects for successful collaborative initiatives, a critical determinant of future success, are excellent. ..
- COREGISTERED IMAGES OF BREAST TUMORS BY MRI AND OPTICALBritton Chance; Fiscal Year: 2003..Large scale tests are available under other support where a direct comparison with not only MRI but also digital mammography, ultrasound and PET will secure the validation studies. ..
- Phenotype MicroArrays for Drug Toxicity ScreeningBarry Bochner; Fiscal Year: 2003..In future studies (Phase II SBIR) we will expand the technology and scope of reference drugs tested to build a strong predictive database including cell lines representing more tissues and organs. ..
- Biochemical Mechanisms of VasospasmsJoseph Clark; Fiscal Year: 2003..The ultimate long-term goal for this project is to define the molecular causes of vasospasm in order to develop effective diagnostic, therapeutic and preventative approaches for this cerebral vascular disease. ..
- MOLECULAR AND CHEMICAL DESCRIPTION OF CFTR FUNCTIONPeter Pedersen; Fiscal Year: 2003..The proposed studies are fundamental to understanding structure/function relationships within CFTR, to understanding the underlying basis of most cases of CF, and to developing new strategies to treat the disease. ..
- GONADAL STEROID REGULATION OF THE BIOLOGICAL CLOCKTamas Horvath; Fiscal Year: 2003..abstract_text> ..
- BREAST CANCER HYPOXIA ASSESSED BY NITRIC OXIDEBritton Chance; Fiscal Year: 2002..If ourintended goals of demonstrating feasibility are achieved, then application for support through regular RO1channels would appear to be justified. ..
- P53 AND REPAIR OF DNA DAMAGE BY ANTICANCER DRUGSPeng Huang; Fiscal Year: 2002..Furthermore, the inability of mutant p53 to remove nucleoside analogs from DNA may provide a molecular basis for the design of strategies to selectively kill cancer cells with mutant p53 by therapeutic nucleoside analogs. ..
- ADRIAMYCIN-INDUCED MITOCHONDRIAL CARDIOMYOPATHYKendall Wallace; Fiscal Year: 2004....
- NO HEMOGLOBIN INTERACTION IN THE PULMONARY VASCULATUREJONATHAN STAMLER; Fiscal Year: 2001..abstract_text> ..
- GENETIC AND MOLECULAR STUDIES OF GROUP II INTRONSRONALD BUTOW; Fiscal Year: 2004..Finally, the RNA binding and splicing functions of the naturase domain of the intron-encoded protein will be studied. ..
- CHRONIC ALCOHOLISM AND LIVER ENERGY AND LIPID METABOLISMCarol Cunningham; Fiscal Year: 2004..Phosphorus NMR spectroscopy will be utilized heavily in these latter studies. ..
- FREE RADICALS AND MUSCLE DYSFUNCTION IN HEART FAILUREGERALD SUPINSKI; Fiscal Year: 2005..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of heart failure-related skeletal muscle dysfunction. ..
- 2 & 3D Imaging of Contrast Agents in Animal ModelsBritton Chance; Fiscal Year: 2004..abstract_text> ..
- Images of Quantified Hypoxic Stress in MuscleBritton Chance; Fiscal Year: 2005..Our especial goals are improving geriatric performance and detecting mitochondrial disease. See Appendix A for Glossary. ..
- Cytochrome Oxidase Polymorphisms in AgingRussell Swerdlow; Fiscal Year: 2007..This work could help explain why complex genetic diseases are sometimes associated with mitochondrial dysfunction. ..
- OXIDATIVE PHOSPHORYLATION IN CELL GROWTH AND DEATHCARLOS TORRES MORAES; Fiscal Year: 2010..abstract_text> ..
- ANTERO POSTERIOR PATTERN FORMATION IN C ELEGANSCynthia Kenyon; Fiscal Year: 2001..Together these studies should help to define the molecular mechanisms that regulate and execute these migrations. ..
- Ethanol effects on liver in self-administering primatesCarol Cunningham; Fiscal Year: 2004..fascicularis will develop liver pathology past the fatty liver stage and 2) to evaluate the efficacy of using blood and urine samples to follow development of alcoholic liver disease in an animal model. ..
- Microarrays for Alzheimer's Disease Mouse ModelsP Reddy; Fiscal Year: 2003..The outcome of this proposed investigation will be useful in screening several mitochondrial antioxidants in AD transgenic mouse models as pre-clinical trials of AD patients...
- FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (fNIRI)Britton Chance; Fiscal Year: 2005..These projects represent logical continuations of current activities into new and related researches. ..
- CONTROL OF ENZYMATIC PHOSPHATE TRANSFER IN MITOCHONDRIAPeter Pedersen; Fiscal Year: 2009..These studies also have direct relevance to using nanotechnology in medicine as the ATP synthasome is comprised of 2 reversible nanomotors. ..
- CYTOCHROME OXIDASE ASSEMBLY GENES IN HUMAN DISEASEERIC SCHON; Fiscal Year: 2003..abstract_text> ..
- Neuroprotection After Cardiac ArrestGary Fiskum; Fiscal Year: 2006..S. alone, and over half of these suffering from neurological morbidity and mortality, the potential impact of the proposed translational research project is highly significant. ..
- Antioxidants and oxidative damage in mitochondriaCecilia Giulivi; Fiscal Year: 2004..Structure-activity association of naturally occurring flavonoids in the abrogation of protein nitration, and 4. Bioavailability of flavonoids containing diets in nitrative stress. ..
- Phenotype MicroArrays for Drug Toxicity ScreeningBarry Bochner; Fiscal Year: 2007....
- REGULATION OF C1 METABOLISM IN METHYLOTROPHSMary Lidstrom; Fiscal Year: 2007..abstract_text> ..
- GENETIC ANALYSIS OF AGING IN C ELEGANSCynthia Kenyon; Fiscal Year: 2003..Understanding this pathway in detail will ultimately answer the two most important questions in the aging field: how the aging process itself takes place, and how it can be regulated by endocrine signaling. ..
- PHYSIOLOGY OF RESPIRATORY MUSCLE CELLSMichael Reid; Fiscal Year: 2005..Results of the proposed studies will help establish molecular mechanisms whereby TNFalpha stimulates catabolism of respiratory and limb skeletal muscle. ..