cell movement

Summary

Summary: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.

Top Publications

  1. ncbi Epithelial-mesenchymal transitions in tumour progression
    Jean Paul Thiery
    Centre National Recherche Scientifique Unité Mixte Recherche, 144 Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Rev Cancer 2:442-54. 2002
  2. pmc AKT/PKB signaling: navigating downstream
    Brendan D Manning
    Department of Genetics and Complex Diseases, Harvard School of Public Health, SPH2 117, Boston, MA 02115, USA
    Cell 129:1261-74. 2007
  3. ncbi Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    Axel Nimmerjahn
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany
    Science 308:1314-8. 2005
  4. ncbi Identification of a cancer stem cell in human brain tumors
    Sheila K Singh
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Cancer Res 63:5821-8. 2003
  5. ncbi Cell migration: integrating signals from front to back
    Anne J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK
    Science 302:1704-9. 2003
  6. ncbi Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    Li Ma
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 449:682-8. 2007
  7. pmc Myeloid-derived suppressor cells as regulators of the immune system
    Dmitry I Gabrilovich
    Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Nat Rev Immunol 9:162-74. 2009
  8. ncbi Rho GTPases in cell biology
    Sandrine Etienne-Manneville
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, Cancer Research UK Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Nature 420:629-35. 2002
  9. ncbi MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    Fanyin Meng
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas, USA
    Gastroenterology 133:647-58. 2007
  10. ncbi Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    Hector Peinado
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Rev Cancer 7:415-28. 2007

Research Grants

Detail Information

Publications329 found, 100 shown here

  1. ncbi Epithelial-mesenchymal transitions in tumour progression
    Jean Paul Thiery
    Centre National Recherche Scientifique Unité Mixte Recherche, 144 Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Rev Cancer 2:442-54. 2002
  2. pmc AKT/PKB signaling: navigating downstream
    Brendan D Manning
    Department of Genetics and Complex Diseases, Harvard School of Public Health, SPH2 117, Boston, MA 02115, USA
    Cell 129:1261-74. 2007
    ..In addition, we discuss those Akt substrates that are most likely to contribute to the diverse cellular roles of Akt, which include cell survival, growth, proliferation, angiogenesis, metabolism, and migration...
  3. ncbi Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    Axel Nimmerjahn
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany
    Science 308:1314-8. 2005
    ..Microglia thus are busy and vigilant housekeepers in the adult brain...
  4. ncbi Identification of a cancer stem cell in human brain tumors
    Sheila K Singh
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Cancer Res 63:5821-8. 2003
    ..The identification of a BTSC provides a powerful tool to investigate the tumorigenic process in the central nervous system and to develop therapies targeted to the BTSC...
  5. ncbi Cell migration: integrating signals from front to back
    Anne J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK
    Science 302:1704-9. 2003
    ....
  6. ncbi Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    Li Ma
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 449:682-8. 2007
    ....
  7. pmc Myeloid-derived suppressor cells as regulators of the immune system
    Dmitry I Gabrilovich
    Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Nat Rev Immunol 9:162-74. 2009
    ..In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit...
  8. ncbi Rho GTPases in cell biology
    Sandrine Etienne-Manneville
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, Cancer Research UK Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Nature 420:629-35. 2002
    ..With spatial and temporal activation of multiple switches factored in, it is not surprising to find Rho GTPases having such a prominent role in eukaryotic cell biology...
  9. ncbi MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    Fanyin Meng
    Department of Internal Medicine, Scott and White Clinic, Texas A and M University System Health Science Center College of Medicine, Temple, Texas, USA
    Gastroenterology 133:647-58. 2007
    ..Although a role for aberrant miRNA expression in cancer has been postulated, the pathophysiologic role and relevance of aberrantly expressed miRNA to tumor biology has not been established...
  10. ncbi Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    Hector Peinado
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Rev Cancer 7:415-28. 2007
    ....
  11. ncbi Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    Jing Yang
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Cell 117:927-39. 2004
    ..These results establish a mechanistic link between Twist, EMT, and tumor metastasis...
  12. ncbi Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis
    Jing Yang
    Department of Pharmacology and Pediatrics, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Dev Cell 14:818-29. 2008
    ..Studies in both fields are critical for our molecular understanding of cell migration and morphogenesis...
  13. ncbi In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro
    Chun Chi Liang
    Division of Molecular Medicine and Genetics and Cell and Developmental Biology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nat Protoc 2:329-33. 2007
    ..Not taking into account the time for transfection of cells, in vitro scratch assay per se usually takes from several hours to overnight...
  14. ncbi Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
    Antoine E Karnoub
    Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nature 449:557-63. 2007
    ..Collectively, these data demonstrate that the tumour microenvironment facilitates metastatic spread by eliciting reversible changes in the phenotype of cancer cells...
  15. ncbi The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    A Cano
    Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Cell Biol 2:76-83. 2000
    ..Snail may thus be considered as a marker for malignancy, opening up new avenues for the design of specific anti-invasive drugs...
  16. ncbi Rho GTPases and the actin cytoskeleton
    A Hall
    Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Science 279:509-14. 1998
    ....
  17. ncbi Blood monocytes consist of two principal subsets with distinct migratory properties
    Frederic Geissmann
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Immunity 19:71-82. 2003
    ..These findings raise the potential for novel therapeutic strategies in inflammatory diseases...
  18. ncbi Getting to the site of inflammation: the leukocyte adhesion cascade updated
    Klaus Ley
    Robert M Berne Cardiovascular Research Center and Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Rev Immunol 7:678-89. 2007
    ..This Review focuses on new aspects of one of the central paradigms of inflammation and immunity--the leukocyte adhesion cascade...
  19. ncbi Cancer invasion and the microenvironment: plasticity and reciprocity
    Peter Friedl
    Department of Cell Biology, Radboud University Nijmegen Medical Centre, 6500 HC Nijmegen, The Netherlands
    Cell 147:992-1009. 2011
    ..The resulting "plasticity" contributes to the generation of diverse cancer invasion routes and programs, enhanced tumor heterogeneity, and ultimately sustained metastatic dissemination...
  20. pmc Actin, a central player in cell shape and movement
    Thomas D Pollard
    Department of Molecular, Cellular and Developmental Biology, Yale University, Post Office Box 208103, New Haven, CT 06520 8103, USA
    Science 326:1208-12. 2009
    ..Comparisons of quantitative measurements of reactions in live cells with computer simulations of mathematical models will also help generate meaningful insights...
  21. pmc Endogenous human microRNAs that suppress breast cancer metastasis
    Sohail F Tavazoie
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nature 451:147-52. 2008
    ..miR-335 and miR-126 are thus identified as metastasis suppressor microRNAs in human breast cancer...
  22. ncbi Calcium signaling
    David E Clapham
    Aldo R Castañeda Professor of Cardiovascular Research, Professor of Neurobiology, Harvard Medical School, Howard Hughes Medical Institute, Enders 1309, Children s Hospital Boston, Boston, MA 02115, USA
    Cell 131:1047-58. 2007
    ..Also discussed is the highly localized nature of Ca(2+)-mediated signal transduction and its specific roles in excitability, exocytosis, motility, apoptosis, and transcription...
  23. ncbi Integrin-regulated FAK-Src signaling in normal and cancer cells
    Satyajit K Mitra
    The Scripps Research Institute, Department of Immunology, IMM21 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Curr Opin Cell Biol 18:516-23. 2006
    ....
  24. ncbi Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    Akira Orimo
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 121:335-48. 2005
    ..Our findings indicate that fibroblasts within invasive breast carcinomas contribute to tumor promotion in large part through the secretion of SDF-1...
  25. ncbi Molecular requirements for epithelial-mesenchymal transition during tumor progression
    Margit A Huber
    Department of Dermatology, Vienna Medical University, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Curr Opin Cell Biol 17:548-58. 2005
    ..Increasing evidence suggests that EMT plays a specific role in the migration of cells from a primary tumor into the circulation and may provide a rationale for developing more effective cancer therapies...
  26. pmc Cell adhesion: integrating cytoskeletal dynamics and cellular tension
    J Thomas Parsons
    Department of Microbiology, School of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Rev Mol Cell Biol 11:633-43. 2010
    ..Adhesion formation and disassembly drive the migration cycle by activating Rho GTPases, which in turn regulate actin polymerization and myosin II activity, and therefore adhesion dynamics...
  27. ncbi The ins and outs of the epithelial to mesenchymal transition in health and disease
    M Angela Nieto
    Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas Universidad Miguel Hernandez, San Juan de Alicante 03550, Spain
    Annu Rev Cell Dev Biol 27:347-76. 2011
    ..In addition, the EMT now constitutes a promising target for the treatment of cancer and organ-degenerative diseases...
  28. ncbi Central memory and effector memory T cell subsets: function, generation, and maintenance
    Federica Sallusto
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Annu Rev Immunol 22:745-63. 2004
    ..This review addresses the heterogeneity of TCM and TEM, their differentiation stages, and the current models for their generation and maintenance in humans and mice...
  29. ncbi Focal adhesion kinase: in command and control of cell motility
    Satyajit K Mitra
    The Scripps Research Institute, Department of Immunology, IMM21 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Mol Cell Biol 6:56-68. 2005
    ..Through multifaceted and diverse molecular connections, FAK can influence the cytoskeleton, structures of cell adhesion sites and membrane protrusions to regulate cell movement.
  30. pmc The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    Manav Korpal
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Biol Chem 283:14910-4. 2008
    ..These results suggested that loss of expression of the miR-200 family members may play a critical role in the repression of E-cadherin by ZEB1 and ZEB2 during EMT, thereby enhancing migration and invasion during cancer progression...
  31. ncbi Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease
    M Vasa
    Division of Molecular Cardiology, Department of Internal Medicine IV, University of Frankfurt, Germany
    Circ Res 89:E1-7. 2001
    ..The full text of this article is available at http://www.circresaha.org...
  32. ncbi Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
    Daniel J Ceradini
    Laboratory of Microvascular Research and Vascular Tissue Engineering, Institute of Reconstructive Plastic Surgery, New York University School of Medicine, New York, New York 10016, USA
    Nat Med 10:858-64. 2004
    ..These data show that the recruitment of CXCR4-positive progenitor cells to regenerating tissues is mediated by hypoxic gradients via HIF-1-induced expression of SDF-1...
  33. pmc The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function
    Danielle A Murphy
    Sanford Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Mol Cell Biol 12:413-26. 2011
    ..Recently, progress has been made in our understanding of the regulatory and functional aspects of podosome and invadopodium biology and their role in human disease...
  34. ncbi The interleukin-8 pathway in cancer
    David J J Waugh
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, Northern Ireland
    Clin Cancer Res 14:6735-41. 2008
    ..Therefore, inhibiting the effects of IL-8 signaling may be a significant therapeutic intervention in targeting the tumor microenvironment...
  35. ncbi Met, metastasis, motility and more
    Carmen Birchmeier
    Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13122 Berlin, Germany
    Nat Rev Mol Cell Biol 4:915-25. 2003
  36. ncbi Life at the leading edge
    Anne J Ridley
    Randall Division of Cell and Molecular Biophysics, King s College London, New Hunt s House, Guy s Campus, London SE1 1UL, United Kingdom
    Cell 145:1012-22. 2011
    ..In addition, these different protrusion methods likely act in concert to move cells through complex environments in vivo...
  37. pmc Non-muscle myosin II takes centre stage in cell adhesion and migration
    Miguel Vicente-Manzanares
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Nat Rev Mol Cell Biol 10:778-90. 2009
    ....
  38. ncbi Macrophages: obligate partners for tumor cell migration, invasion, and metastasis
    John Condeelis
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Cell 124:263-6. 2006
    ..Thus, macrophages are at the center of the invasion microenvironment and are an important drug target for cancer therapy...
  39. pmc Plasticity of cell migration: a multiscale tuning model
    Peter Friedl
    Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, 6500 HB Nijmegen, Netherlands
    J Cell Biol 188:11-9. 2010
    ..The tuning model provides a matrix of parameters that control cell movement as an adaptive and interconvertible process with relevance to different physiological and pathological contexts...
  40. ncbi Collective cell migration in morphogenesis, regeneration and cancer
    Peter Friedl
    Microscopical Imaging of the Cell, Department of Cell Biology 283, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Nat Rev Mol Cell Biol 10:445-57. 2009
    ..Comparing different types of collective migration at the molecular and cellular level reveals a common mechanistic theme between developmental and cancer research...
  41. ncbi Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing
    Giselle Chamberlain
    Leopold Muller Arthritis Research Centre, School of Medicine, Keele University, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shrops SY10 7AG, UK
    Stem Cells 25:2739-49. 2007
    ..The current review describes what is known about MSCs and their capacity to home to tissues together with the associated molecular mechanisms involving chemokine receptors and adhesion molecules...
  42. ncbi Neuronal replacement from endogenous precursors in the adult brain after stroke
    Andreas Arvidsson
    Section of Restorative Neurology, Wallenberg Neuroscience Center, Lund University Hospital, Lund, Sweden
    Nat Med 8:963-70. 2002
    ..If the new neurons are functional and their formation can be stimulated, a novel therapeutic strategy might be developed for stroke in humans...
  43. pmc Convergence of Wnt, beta-catenin, and cadherin pathways
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 303:1483-7. 2004
    ..Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, beta-catenin functions, and cadherin-mediated adhesion...
  44. ncbi Cellular motility driven by assembly and disassembly of actin filaments
    Thomas D Pollard
    Department of Cellular, Molecular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 112:453-65. 2003
    ..Profilin catalyzes the exchange of ADP for ATP, refilling the pool of ATP-actin monomers bound to profilin, ready for elongation...
  45. pmc VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    Rosandra N Kaplan
    Department of Pediatrics and the Children s Blood Foundation Laboratories, Weill Cornell Medical College of Cornell University, New York, New York 10021, USA
    Nature 438:820-7. 2005
    ..These findings demonstrate a requirement for VEGFR1+ haematopoietic progenitors in the regulation of metastasis, and suggest that expression patterns of fibronectin and VEGFR1+VLA-4+ clusters dictate organ-specific tumour spread...
  46. pmc Integrins in cell migration
    Anna Huttenlocher
    Departments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, Wsconsin 53706, USA
    Cold Spring Harb Perspect Biol 3:a005074. 2011
    ..Finally, we address mechanisms of adhesion assembly and disassembly and the role of adhesion in cellular polarity...
  47. pmc Coordination of Rho GTPase activities during cell protrusion
    Matthias Machacek
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, California 92037, USA
    Nature 461:99-103. 2009
    ....
  48. pmc Evidence that fibroblasts derive from epithelium during tissue fibrosis
    Masayuki Iwano
    Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
    J Clin Invest 110:341-50. 2002
    ..As a general mechanism, this change in fate highlights the potential plasticity of differentiated cells in adult tissues under pathologic conditions...
  49. ncbi Taking cell-matrix adhesions to the third dimension
    E Cukierman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    Science 294:1708-12. 2001
    ..These distinctive in vivo 3D-matrix adhesions differ in structure, localization, and function from classically described in vitro adhesions, and as such they may be more biologically relevant to living organisms...
  50. ncbi Rac activation and inactivation control plasticity of tumor cell movement
    Victoria Sanz-Moreno
    Institute of Cancer Research, Cancer Research UK Centre for Cell and Molecular Biology, 237 Fulham Road, London SW3 6JB, UK
    Cell 135:510-23. 2008
    Tumor cells exhibit two different modes of individual cell movement. Mesenchymal-type movement is characterized by an elongated cellular morphology and requires extracellular proteolysis...
  51. ncbi The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment
    Alexander Greenhough
    Department of Cellular and Molecular Medicine, Cancer Research UK Colorectal Tumour Biology Group, University of Bristol, University Walk, Clifton, Bristol, UK
    Carcinogenesis 30:377-86. 2009
    ....
  52. ncbi Regulation of cadherin-mediated adhesion in morphogenesis
    Barry M Gumbiner
    Department of Cell Biology, University of Virginia, School of Medicine, PO Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Rev Mol Cell Biol 6:622-34. 2005
    ..Signal-transduction pathways impinge on the catenins (cytoplasmic cadherin-associated proteins), which transduce changes across the membrane to alter the state of the cadherin adhesive bond...
  53. ncbi A MicroRNA targeting dicer for metastasis control
    Graziano Martello
    Department of Histology, Microbiology and Medical Biotechnologies, University of Padua School of Medicine, viale Colombo 3, 35126 Padua, Italy
    Cell 141:1195-207. 2010
    ..These findings suggest a new pathway by which Dicer inhibition drifts epithelial cancer toward a less-differentiated, mesenchymal fate to foster metastasis...
  54. ncbi Adult neurogenesis in the mammalian central nervous system
    Guo li Ming
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Annu Rev Neurosci 28:223-50. 2005
    ..Advances in our understanding of adult neurogenesis will not only shed light on the basic principles of adult plasticity, but also may lead to strategies for cell replacement therapy after injury or degenerative neurological diseases...
  55. ncbi T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    Thorsten R Mempel
    The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 427:154-9. 2004
    ....
  56. ncbi Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior
    Cedric Auffray
    Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
    Science 317:666-70. 2007
    ....
  57. ncbi The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    J Comijn
    Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
    Mol Cell 7:1267-78. 2001
    ..SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors...
  58. ncbi Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1
    Mehrdad Matloubian
    Howard Hughes Medical Institute and Department of Microbiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0414, USA
    Nature 427:355-60. 2004
    ..These findings establish that S1P1 is essential for lymphocyte recirculation and that it regulates egress from both thymus and peripheral lymphoid organs...
  59. ncbi Role of integrins in cell invasion and migration
    John D Hood
    Scripps Research Institute, Departments of Immunology and Vascular Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Cancer 2:91-100. 2002
    ..Integrins are crucial for cell invasion and migration, not only for physically tethering cells to the matrix, but also for sending and receiving molecular signals that regulate these processes...
  60. ncbi Endothelial cell migration during angiogenesis
    Laurent Lamalice
    Le Centre de recherche en cancérologie, l Université Laval, L Hôtel Dieu de Québec, Quebec, Canada
    Circ Res 100:782-94. 2007
    ..The aim of this review is to give an integrative view of the signaling mechanisms that govern endothelial cell migration in the context of angiogenesis...
  61. pmc MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
    William Kong
    Departments of Molecular Oncology, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, SRB3, Tampa, FL 33612, USA
    Mol Cell Biol 28:6773-84. 2008
    ..These data suggest that miR-155 may play an important role in TGF-beta-induced EMT and cell migration and invasion by targeting RhoA and indicate that it is a potential therapeutic target for breast cancer intervention...
  62. pmc The Arp2/3 complex is required for lamellipodia extension and directional fibroblast cell migration
    Praveen Suraneni
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    J Cell Biol 197:239-51. 2012
    ..These results provide insights into the Arp2/3 complex's critical role in lamellipodia extension and directional fibroblast migration...
  63. ncbi CD44: from adhesion molecules to signalling regulators
    Helmut Ponta
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, PO Box 3640, 76021 Karlsruhe, Germany
    Nat Rev Mol Cell Biol 4:33-45. 2003
    ..CD44 and its associated partner proteins monitor changes in the extracellular matrix that influence cell growth, survival and differentiation...
  64. ncbi Filopodia: molecular architecture and cellular functions
    Pieta K Mattila
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Rev Mol Cell Biol 9:446-54. 2008
    ..The increased understanding of the functions of various actin-associated proteins during the initiation and elongation of filopodia has provided new information on the mechanisms of filopodia formation in distinct cell types...
  65. ncbi Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases
    Stephen C Noctor
    Department of Neurology, Columbia University College of Physicians and Surgeons, 630 W 168th Street, New York, New York 10032, USA
    Nat Neurosci 7:136-44. 2004
    ..These findings provide a comprehensive and new view of the dynamics of cortical neurogenesis and migration...
  66. ncbi Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression
    Thomas Brabletz
    Department of Pathology, University of Erlangen, Krankenhausstr 8 10, 91054 Erlangen, Germany
    Nat Rev Cancer 5:744-9. 2005
    ..We suggest an extended, integrated model that is consistent with all aspects of human tumour progression - the 'migrating cancer stem (MCS)-cell' concept...
  67. ncbi Mutant p53 drives invasion by promoting integrin recycling
    Patricia A J Muller
    The Beatson Institute for Cancer Research, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Cell 139:1327-41. 2009
    ..These findings open the possibility that blocking alpha5/beta1-integrin and/or the EGF receptor will have therapeutic benefit in mutant p53-expressing cancers...
  68. ncbi Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer
    K Vuoriluoto
    Medical Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland
    Oncogene 30:1436-48. 2011
    ..Moreover, these results provide a molecular explanation for vimentin-dependent cancer cell migration during EMT by identifying Axl as a key proximal component in this process...
  69. ncbi Toll-like receptor control of the adaptive immune responses
    Akiko Iwasaki
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Immunol 5:987-95. 2004
    ..Recent studies have provided important clues about the mechanisms of TLR-mediated control of adaptive immunity orchestrated by dendritic cell populations in distinct anatomical locations...
  70. pmc Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand
    Beate Heissig
    Division of Hematology Oncology, Cornell University Medical College, New York, NY 10021, USA
    Cell 109:625-37. 2002
    ..Release of sKitL by MMP-9 enables BM repopulating cells to translocate to a permissive vascular niche favoring differentiation and reconstitution of the stem/progenitor cell pool...
  71. ncbi FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
    Donna J Webb
    Department of Cell Biology, UVA School of Medicine, P O Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Cell Biol 6:154-61. 2004
    ....
  72. ncbi Adhesion signaling - crosstalk between integrins, Src and Rho
    Stephan Huveneers
    Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands
    J Cell Sci 122:1059-69. 2009
    ..We also discuss how this signaling network can regulate a range of cellular processes that are important for normal tissue function and disease, including cell adhesion, spreading, migration and mechanotransduction...
  73. ncbi Rapid leukocyte migration by integrin-independent flowing and squeezing
    Tim Lämmermann
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Nature 453:51-5. 2008
    ..Myosin II-dependent contraction is only required on passage through narrow gaps, where a squeezing contraction of the trailing edge propels the rigid nucleus...
  74. ncbi Immune cell migration in inflammation: present and future therapeutic targets
    Andrew D Luster
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Immunol 6:1182-90. 2005
    ....
  75. ncbi Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells
    Cedric Gaggioli
    Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Nat Cell Biol 9:1392-400. 2007
    ..Instead, carcinoma cells use Cdc42 and MRCK (myotonic dystrophy kinase-related CDC42-binding protein kinases) mediated regulation of MLC to follow the tracks generated by fibroblasts...
  76. ncbi MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8
    L Fang
    Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Oncogene 30:806-21. 2011
    ..Our results suggest that inhibition of miR-93 function may be a feasible approach to suppress angiogenesis and tumor growth...
  77. ncbi Epidermal growth factor receptor: mechanisms of activation and signalling
    Robert N Jorissen
    Ludwig Institute for Cancer Research, Parkville, Victoria, Australia
    Exp Cell Res 284:31-53. 2003
    ..The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes...
  78. ncbi Neurogenesis in adult subventricular zone
    Arturo Alvarez-Buylla
    Department of Neurological Surgery, Brain Tumor Research Center, San Francisco, California 94143 0520, USA
    J Neurosci 22:629-34. 2002
  79. ncbi Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions
    Michael D Schaller
    Department of Biochemistry, Mary Babb Randolph Cancer Center and Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, WV 26506, USA
    J Cell Sci 123:1007-13. 2010
    ..This Commentary summarizes some of these recent discoveries that are relevant to the control of biological responses of the cell...
  80. ncbi Cost of migration: invasion of malignant gliomas and implications for treatment
    A Giese
    Department of Neurosurgery, University Hospital Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    J Clin Oncol 21:1624-36. 2003
    ....
  81. pmc p53 and its mutants in tumor cell migration and invasion
    Patricia A J Muller
    Beatson Institute for Cancer Research, Glasgow G61 1BD, Scotland, UK
    J Cell Biol 192:209-18. 2011
    ..Moreover, recent data suggests that expression of mutant p53 is not the equivalent of p53 loss, and that mutant p53s can acquire new functions to drive cell migration, invasion, and metastasis, in part by interfering with p63 function...
  82. pmc Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
    Hervé Acloque
    Instituto de Neurociencias CSIC UMH, San Juan de Alicante, Spain
    J Clin Invest 119:1438-49. 2009
    ..Cells undergo EMT to migrate and colonize distant territories. Not surprisingly, this is also the mechanism used by cancer cells to disperse throughout the body...
  83. pmc miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer
    T Chiyomaru
    Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima, Japan
    Br J Cancer 102:883-91. 2010
    ..We have recently identified down-regulated microRNAs including miR-145 and miR-133a in bladder cancer (BC). The aim of this study is to determine the genes targeted by miR-145, which is the most down-regulated microRNA in BC...
  84. ncbi Microglia in the CNS: immigrants from another world
    Marco Prinz
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Glia 59:177-87. 2011
    ..These new aspects will be discussed in the present review...
  85. pmc miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis
    Michiel Smits
    Neuro oncology Research Group, Departments of Neurosurgery and Pediatric Oncology Hematology, Cancer Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Oncotarget 1:710-20. 2010
    ..GBM is characterized by fast cell proliferation, infiltrative migration, and by the induction of angiogenesis. MicroRNAs and polycomb group (PcG) proteins have emerged as important regulators of gene expression...
  86. pmc Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis
    Muhammad H Zaman
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:10889-94. 2006
    ..that, in addition to adhesion and tractile forces, matrix stiffness is a key factor that influences cell movement in 3D...
  87. ncbi Mechanical integration of actin and adhesion dynamics in cell migration
    Margaret L Gardel
    Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Cell Dev Biol 26:315-33. 2010
    ....
  88. ncbi Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization
    Jun Ichi Yamaguchi
    Division of Cardiovascular Research and Medicine, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Mass 02135, USA
    Circulation 107:1322-8. 2003
    ..Given the close relationship between hematopoietic stem cells and endothelial progenitor cells (EPCs), we investigated the effect of SDF-1 on EPC-mediated vasculogenesis...
  89. ncbi miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells
    Na Li
    Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, PR China
    Cancer Lett 275:44-53. 2009
    ..Taken together, these results provide evidence to show the suppression role of miR-34a in tumor migration and invasion through modulation of the c-Met signaling pathway...
  90. pmc Planar cell polarity acts through septins to control collective cell movement and ciliogenesis
    Su Kyoung Kim
    Section of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Science 329:1337-40. 2010
    ..control of septin localization by the PCP protein Fritz as a crucial control point for both collective cell movement and ciliogenesis in Xenopus embryos...
  91. ncbi Maturation and death of adult-born olfactory bulb granule neurons: role of olfaction
    Leopoldo Petreanu
    The Rockefeller University, New York, New York 10021, USA
    J Neurosci 22:6106-13. 2002
    ..This selection mechanism might allow the construction of specific OB circuits based on olfactory experience and suggests possible functions of OB cell replacement...
  92. ncbi Transient expression of doublecortin during adult neurogenesis
    Jason P Brown
    Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
    J Comp Neurol 467:1-10. 2003
    ..This assumption is further supported by our observation that the number of DCX-expressing cells in the dentate gyrus was decreased with age according to the reduction of neurogenesis in the aging dentate gyrus previously reported...
  93. ncbi Regulation of actin assembly associated with protrusion and adhesion in cell migration
    Christophe Le Clainche
    Laboratoire d Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Physiol Rev 88:489-513. 2008
    ..III) focuses on the function and the regulation of major proteins (vinculin, talin, tensin, and alpha-actinin) that control the nucleation, the binding, and the barbed-end growth of actin filaments in adhesions...
  94. pmc Origin of the lamina propria dendritic cell network
    Milena Bogunovic
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Immunity 31:513-25. 2009
    ..Altogether, these results underline the diverse origin of the lamina propria DC network and identify mucosal DCs that arise from pre-DCs as key sentinels of the gut immune system...
  95. pmc CXCR4 and CXCR7 have distinct functions in regulating interneuron migration
    Yanling Wang
    Department of Psychiatry, University of California, San Francisco, CA 94158, USA
    Neuron 69:61-76. 2011
    ..On the other hand, CXCL12 stimulation of CXCR7, but not CXCR4, promoted MAP kinase signaling. Thus, we suggest that CXCR4 and CXCR7 have distinct roles and signal transduction in regulating interneuron movement and laminar positioning...
  96. ncbi The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes
    Karl Balabanian
    Unite d Immunologie Virale, Institut Pasteur, 75015 Paris, France
    J Biol Chem 280:35760-6. 2005
    ..In CXCR4-negative cells expressing RDC1, CXCL12 promotes internalization of the receptor and chemotactic signals through RDC1. Collectively, our data indicate that RDC1, which we propose to rename as CXCR7, is a receptor for CXCL12...
  97. ncbi Cell migration in the forebrain
    Oscar Marin
    Unidad de Neurobiologia del Desarrollo, Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas Universidad Miguel Hernandez, 03550 San Juan de Alicante, Spain
    Annu Rev Neurosci 26:441-83. 2003
    ....
  98. ncbi Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer
    Patrick C Hermann
    Department of Surgery, Ludwig Maximilians University, 81377 Munich, Germany
    Cell Stem Cell 1:313-23. 2007
    ..Strategies aimed at modulating the SDF-1/CXCR4 axis may have important clinical applications to inhibit metastasis of cancer stem cells...
  99. ncbi CCR7 and its ligands: balancing immunity and tolerance
    Reinhold Forster
    Institute of Immunology, Hannover Medical School 30625 Hannover, Germany
    Nat Rev Immunol 8:362-71. 2008
    ..Here, we focus on the cellular and molecular mechanisms that enable CCR7 and its two ligands, CCL19 and CCL21, to balance immunity and tolerance...
  100. ncbi A protein related to extracellular matrix proteins deleted in the mouse mutant reeler
    G D'ARCANGELO
    Roche Institute of Molecular Biology, Hoffman La Roche, Nutley, New Jersey 07110, USA
    Nature 374:719-23. 1995
    ..The encoded protein resembles extracellular matrix proteins involved in cell adhesion. The reeler phenotype thus seems to reflect a failure of early events associated with brain lamination which are normally controlled by reelin...
  101. pmc MicroRNA-1/206 targets c-Met and inhibits rhabdomyosarcoma development
    Dongsheng Yan
    School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical College, Wenzhou, Zhejiang 325003, China
    J Biol Chem 284:29596-604. 2009
    ..Inhibition of miR-1/206 function could contribute to aberrant cell proliferation and migration, leading to rhabdomyosarcoma development...

Research Grants71

  1. PLD2, as a GEF or as a Lipase, is Central to Leukocyte Chemotaxis
    JULIAN G CAMBRONERO; Fiscal Year: 2013
    ..Since the target, Rac2 Rho GTPase is responsible for cell movement PLD2 might be a major GEF mediating chemotaxis...
  2. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2012
    ..This shows that FAK catalytic activity is not essential for MEF proliferation-survival, but is required for cell movement in vitro and in vivo. To extend these findings, we propose 3 research aims...
  3. The biology of blood-testis barrier dynamics
    C Yan Cheng; Fiscal Year: 2013
    ..to maintain the timely "opening" and "closing" of the BTB during spermatogenesis while facilitating germ cell movement across the barrier...
  4. Regulation of TGF-beta Signaling and Embryonic Development by GTPases
    Gerald H Thomsen; Fiscal Year: 2010
    ..GTPases govern critical cellular processes such as signal transduction, transcription, mitosis, cell shape and cell movement by acting as molecular switches that regulate activity of protein partners...
  5. HORMONAL REGULATION OF MESSENGER RNA STABILITY
    Daniel R Schoenberg; Fiscal Year: 2013
    ..Cell motility is increased in cells expressing active PMR1, and the experiments in Aim 3 will use imag- ing of cell movement, quantitative PCR and immunofluorescence to examine the relationship between motility, PMR1 binding to the Ena/..
  6. Role of Focal Adhesion Kinase (FAK) in Nephrosis and Nephritis
    Shuta Ishibe; Fiscal Year: 2013
    ..project is to define the role of focal adhesion protein, Focal Adhesion Kinase (FAK), a critical regulator of cell movement, in podocyte regulation following injury...
  7. Catenins: A role in spertmatogenesis and sperm maturation
    MANJEET KUMAR RAO; Fiscal Year: 2010
    ..In addition, these studies could lead to new insights for therapeutically compromising germ cell movement in the seminiferous epithelium, thereby disrupting spermatogenesis, as a novel approach to reversible male ..
  8. Signaling Connections Controlling Cell Motility and Invasion
    David D Schlaepfer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The elucidation of mechanisms driving cell movement is critical to our understanding of normal development and pathological processes such as tumor invasion...
  9. Role of chemokines in the T cell response to ocular toxoplasmosis
    Christopher A Hunter; Fiscal Year: 2012
    ..migratory behavior in the retina during ocular toxoplasmosis? As chemokines influence various aspects of T cell movement and function (20), multi-photon intravital imagining of the retina is proposed, using fluorescently-labeled ..
  10. Regulation of Synapse Morphogenesis in Drosophila
    David L Van Vactor; Fiscal Year: 2013
    ..predicted to be a direct target of miR-8, and controls aspects of cytoskeletal structure and dynamics during cell movement and cell junction formation, but its role(s) at the synapse are not understood...
  11. Systems microscopy analysis of tumor cell motility in microenvironment context
    Bojana Gligorijevic; Fiscal Year: 2013
    ..In primary tumors, there are numerous biomechanical signals able to direct tumor cell movement towards and into the blood vessels...
  12. Synthetic Fabs for Crystallization of Chemokine:Receptor Complexes
    Tracy M Handel; Fiscal Year: 2013
    ..where they induce conformational changes that trigger intracellular signaling pathways involved in adhesion, cell movement and ultimately, defense-related immune responses...
  13. Reactive Oxygen Species Regulation of Vascular Smooth Muscle Cell Migration
    David S Weber; Fiscal Year: 2012
    ..The identification of mechanisms underlying this cell movement will allow for the design of better approaches to treatment of the complications in patients as well as ..
  14. Role of p190RhoGEF (Rgnef) in cell motility and tumor progression
    Nichol L G Miller; Fiscal Year: 2013
    ..Regulation of cell adhesion and actin cytoskeletal structures play important roles in normal and tumor cell movement. Rho GTPases, such as RhoA, are molecular switches that act to control cell adhesion, motility and have been ..
  15. Role of FGF Signaling in Controlling Cell Movements During Drosophila Development
    ANGELIKE M STATHOPOULOS; Fiscal Year: 2013
    ..mechanism by which FGF signaling acts during development and, in particular, in the coordination of collective cell movement. In Drosophila embryos, signaling through the Heartless FGFR is important for controlling mesoderm spreading ..
  16. Invasion of glioblastoma multiforme (GBM) cells in organotypic brain slices
    ZEV ARI BINDER; Fiscal Year: 2013
    ..Additional information relating tumor cell movement to extracellular structures such as vasculature and neurons will be obtained. Specific Aim 2...
  17. DYNAMICS OF ASSEMBLY OF BONE MATRIX PROTEINS
    Sarah L Dallas; Fiscal Year: 2013
    ..These studies also suggest a novel role for cell movement in ECM assembly and reorganization...
  18. Autoantibodies and B Cell Chemotaxis in Sjogren's Syndrome
    JILL MARIE KRAMER; Fiscal Year: 2013
    ..This proposal seeks to evaluate autoantibodies and a factor affecting B cell movement in disease...
  19. Biophysical Mechanisms of Drosophila Development.
    Jennifer A Zallen; Fiscal Year: 2013
    ..known about how cells sense and respond to mechanical signals to translate mechanical forces into directional cell movement. In the Drosophila embryo, the polarized cell rearrangements that drive body axis elongation are guided by the ..
  20. Roles of microRNAs during vertebrate brain morphogenesis
    Carter M Takacs; Fiscal Year: 2012
    ..This proposal aims to determine how miR-430 governs gene expression to shape cell movement and organization during brain morphogenesis...
  21. Regulation of call adhesion in Xenopus
    KEN CHO; Fiscal Year: 2009
    ..protocadherins and integrins have been implicated in the differential regulation of cell adhesion and cell movement. Growth factors known to be involved in mesoderm patterning such as Wnt and activin/nodal also influence ..
  22. HA in fungal allergic asthma
    Jane M Schuh; Fiscal Year: 2013
    ..Our preliminary ex vivo data show that low molecular mass (LMM) HA activates not only B cell movement but also pro-fibrotic/pro-allergy cytokine production by B cells...
  23. Actin-Based Motility of a Bacterial Pathogen
    Julie A Theriot; Fiscal Year: 2013
    ..the results of our research would contribute to our understanding of a wide variety of basic biological processes involving actin-based cell movement, including wound healing, inflammation, embryonic development, and cancer metastasis.
  24. Rapid-Scanning Prairie Multiphoton Microscope System for Molecular Biology Models
    SAMUEL SHENG HUNG WANG; Fiscal Year: 2010
    ..at Princeton which will benefit greatly from the Prairie system include studies of mRNA transport and cell movement in Drosophila oocytes and embryos, herpes virus assembly and transport in neuronal cells, multicellular ..
  25. Adhesion and Cytoskeleton Dynamics in Cell Migration
    Denise J Montell; Fiscal Year: 2013
    ..These observations raise numerous questions. For example, how do the mechanisms of collective cell movement resemble or differ from single cell motility, and how is the great diversity of cell shapes achieved? One ..
  26. Global analysis of mRNA polarization in migrating endothelial cells
    Paul L Fox; Fiscal Year: 2010
    ..to our understanding of cell polarization, our work can reveal new insights into the regulation of cell movement, and has the potential of new interventions to alter motility...
  27. DYNAMICS OF ASSEMBLY OF BONE MATRIX PROTEINS
    SARAH DALLAS; Fiscal Year: 2009
    ..These studies also suggest a novel role for cell movement in ECM assembly and reorganization...
  28. Directed growth cone migration by calcium signals
    James Q Zheng; Fiscal Year: 2011
    ..Directional cell movement is also crucial for many pathological events, especially cancer-cell metastasis...
  29. Spatial regulation of cytoskeleton during chemotaxis
    Chang Y Chung; Fiscal Year: 2012
    ..Chemotaxis also plays a role in disease states such as arthritis, cancer, and multiple sclerosis. Directional cell movement requires a defined cell polarity in which components of the cytoskeleton are differentially localized at the ..
  30. Synaptotagmin A and C in virus movement and plant development
    Asako Uchiyama; Fiscal Year: 2011
    ..We propose that SYTA regulates plant virus cell-to-cell movement, and plant cell macromolecular trafficking, through, plasmodesmata via an endocytic recapture pathway...
  31. Drug development of orally active anti-trypanosomiasis agents
    Bin Su; Fiscal Year: 2013
    ..agents, since they interfere with microtubule dynamics and suppress both trypanosome cell division and cell movement. Tubulin is a well-recognized molecular target for anti- trypanosome drug development...
  32. Regulation of cell polarity during neurulation
    RACHEL MELISSA BREWSTER; Fiscal Year: 2013
    ..We hypothesize that lin stabilizes microtubules in neural cells, thereby polarizing cell movement. In aim 2, we will investigate a novel role for Par3 in positioning the centrosome at the apical cortex during ..
  33. In vivo effects of anthrax toxins:imaging host response & bacterial proliferation
    Ian Justin Glomski; Fiscal Year: 2010
    ..We hypothesize that these conflicting observations regarding cell movement and activation of the host immune response reflect differences in the presence and activity of toxins over the ..
  34. Regulation of cardiac morphogenesis by Nkx genes
    KIMARA L TARGOFF; Fiscal Year: 2010
    ..we will test the hypothesis that nkx genes guide specific aspects of proliferation, cell shape change, cell movement, and/or cell polarity during the process of ventricle assembly. 2...
  35. Role of Phospho-Tyrosine Binding in Mena-Driven Metastasis
    Russell E McConnell; Fiscal Year: 2013
    ..A hallmark trait of metastatic cancer cells is their enhanced sensitivity to growth factors and increased cell movement. It was recently shown that metastatic cancer cells that migrated out of a primary tumor in response to ..
  36. CELL CYCLE REGULATION IN NORMAL AND CANCER CELLS
    James M Roberts; Fiscal Year: 2010
    ..both cell proliferation, through inhibitory interactions with cyclins and cyclin-dependent kinases, and cell movement, through its inhibitory interaction with RhoA...
  37. Functional analysis of methylation in neural crest migration
    KATIE L VERMILLION; Fiscal Year: 2012
    ..This process is similar to cancer and will help us to understand cancer progression, and will also provide us with a better understanding of how defects in neural crest cell movement can lead to birth defects.
  38. Modulating chemokine receptors at the blood-brain barrier under flow
    Richard M Ransohoff; Fiscal Year: 2012
    ..This knowledge is essential as we move towards safely and effectively blocking immune-cell movement into the brain during MS and other diseases.
  39. High throughput cell migration assay amenable to high content imaging
    KEREN HULKOWER; Fiscal Year: 2010
    ..The first generation OrisTM Cell Migration Assay provides 96 wells for investigating the effects of cell movement modulators. It uses silicone stoppers to create exclusion zones...
  40. Dynamics of Rac1 GTPase Activity at De Novo Cell-Cell Adhesions
    KHAMEEKA NICOLE KITT; Fiscal Year: 2012
    ..constant remodeling of the actin cytoskeleton, which functions in many important cellular processes including cell movement and in the establishment and maintenance of cell- cell adhesions...
  41. Roles of sphingosine-1 phosphate phosphohydrolase
    Sarah Spiegel; Fiscal Year: 2012
    ..Emphasis will be on regulation by S1P phosphatases of key elements of directed cell movement downstream of S1 PRs...
  42. Structure-Function studies of human hyaluronidases
    Osnat Herzberg; Fiscal Year: 2012
    ..Repair of injured tissue requires cell movement within the matrix, as does the escape of an abnormal cell (metastasis)...
  43. Gating of Connexin-Based Gap Junction Channels and Hemichannels
    Feliksas Bukauskas; Fiscal Year: 2013
    ..physiological processes such as metabolism, proliferation, function of membrane channels and transporters, cell movement and contractility...
  44. Protein Kinase C Substrates in Human Breast Cancer
    Susan A Rotenberg; Fiscal Year: 2013
    ..at Ser-165 modulates microtubule dynamics such that the growth phase is prolonged, which correlates with cell movement. The significance of [unreadable]-tubulin phosphorylation to microtubule dynamics and cell movement will be ..
  45. Enamelysin Processing Mechanisms in Amelogenesis
    John D Bartlett; Fiscal Year: 2013
    ..N-cadherin expression in epithelial cells promotes cell movement. This opens exciting possibilities wherein MMP20 may facilitate the cadherin switch and facilitate cell ..
  46. ITK: an emerging target for treatment of T cell-mediated autoimmune disease
    Joonsoo Kang; Fiscal Year: 2013
    ..T cells from Itk-/- mice in vitro and in vivo to determine the molecular mechanism by which ITK controls T cell movement into non-lymphoid tissues...
  47. SPECIFICITY OF FIBROBLAST GROWTH FACTOR SIGNALING IN DROSOPHILA
    ANGELIKE M STATHOPOULOS; Fiscal Year: 2010
    ..2) Contribution of location and timing of ligand expression to specificity. 3) Characterization of different ways in which ligands signal through the FGFR. 4) Dissection of how Htl FGFR activation by Pyr and Ths controls cell movement.
  48. Functional analysis of the WAVE3 gene
    John K Cowell; Fiscal Year: 2011
    ..Individual processes such as cell movement, migration and invasion are central to the process and understanding the multitude of controlling mechanisms ..
  49. REGULATION OF ACTIN CAPPING PROTEIN
    John A Cooper; Fiscal Year: 2013
    ..and disassembly of actin filaments in cells and to understand how actin assembly dynamics contribute to cell movement. The creation of free barbed ends of actin filaments is a critical determinant of actin assembly, and capping ..
  50. INTERMEDIATE FILAMENT CELL SURFACE INTERACTIONS
    Robert D Goldman; Fiscal Year: 2010
    ..RELEVANCE: Intermediate Filaments (IF) are structural proteins that are involved in determining cell shape, cell movement, mechanical integrity, and nuclear architecture. However, their specific functions remain unknown...
  51. Cytoskeletal control of Leishmania infection
    DAWN MARIE WETZEL; Fiscal Year: 2012
    ..that transfer signals from extracellular integrin receptors to the cytoskeleton in order to orchestrate cell movement. These kinases are known to activate cortactin, which triggers actin-based cell edge protrusions...
  52. Enamelysin Processing Mechanisms in Amelogenesis
    John D Bartlett; Fiscal Year: 2011
    ..N-cadherin expression in epithelial cells promotes cell movement. This opens exciting possibilities wherein MMP20 may facilitate the cadherin switch and facilitate cell ..
  53. Mechanics of lamellipodial stability, turning and self-polarization
    Alexander Mogilner; Fiscal Year: 2013
    ..Preliminary data and modeling hint that interdependence of force-generating protein distributions and cell movement and geometry underlies cell polarization, turning and splitting...
  54. Genetic Analysis of the Zebrafish Somitogenesis Oscillator
    Scott A Holley; Fiscal Year: 2010
    ..We are Aim III is to characterize the relationship between cell movement and the segmentation clock. Using timelapse imaging and celt tracking, we will determine the velocity...
  55. Heterodimerization of CXCR4 and CB2 Inhibits Prostate Cancer Cell Movement
    Cimona V Hinton; Fiscal Year: 2013
    ....
  56. ApicalMembrane Modeling in Tubulogenesis
    VERENA GOBEL; Fiscal Year: 2010
    ..provided by applicant): Apical membrane modeling shapes organ lumina, defines membrane microdomains and leads cell movement during epithelial morphogenesis...
  57. The Ubiquitin-Proteasome System in Metazoan Embryogenesis
    Zhirong Bao; Fiscal Year: 2013
    ..the behaviors of every cell based on quantitative measurements of cell division, fate marker expression and cell movement. Using these technologies, our genetic and phenotypic analysis will define the specific developmental contexts ..
  58. 2010 Signalling by Adhesion Receptors Gordon Research Conference
    Martin A Schwartz; Fiscal Year: 2010
    ..neighboring cells, and how they convert those signals into changes in cell decision making in differentiation, cell movement, and cell-cell interactions in normal and disease states...
  59. Bacterial Cell Division and the Dynamics of the Z-ring
    Sean X Sun; Fiscal Year: 2013
    ..In the post-genomic era, quantitative modeling is essential for understanding critical cell functions such as cell movement, cell signaling and cell division...
  60. Predoctoral and Postdoctoral Training in Cancer Cell Biology
    Marilyn Gist Farquhar; Fiscal Year: 2013
    ..anti-cancer genes, regulatory kinases, signaling, growth control, G proteins and growth factors, control of cell movement, glycobiology of cancer cells, cellular and molecular genomics, and the development of experimental anticancer ..
  61. TRE17 links actin remodeling & vesicle trafficking
    Margaret Chou; Fiscal Year: 2009
    ..by regulating dynamic actin remodeling and vesicular trafficking, coordination of which is essential for cell movement and invasiveness...
  62. Regulation of a lipid raft trafficking pathway by integrins
    Martin A Schwartz; Fiscal Year: 2013
    ..restricted regulation of lipid raft trafficking via the same pathway and how it contributes to directed cell movement. This work will contribute to our understanding of a pathway that is fundamental to cell behavior as well as ..
  63. REGULATION OF PROTEIN TOBACCO MOSAIC VIRUS RNA COMPLEXES
    Vitaly Citovsky; Fiscal Year: 2002
    ..Potentially, MP phosphorylation may function as a regulatory switch between viral cell-to-cell movement and replication and translation...
  64. PERIODONTAL LIGAMENT CELL AUTOCRINE FACTOR
    VICTOR TERRANOVA; Fiscal Year: 1993
    ..matrix components FN and LM for their contribution to PDL chemotactic and mitogenic factor induced PDL cell movement and proliferative responses...
  65. Hydrogen Deuterium Exchange Mapping of Chemokine Receptor Complex Interfaces
    Tracy Handel; Fiscal Year: 2009
    ..receptors (GPCRs), causing conformational changes that trigger intracellular signaling pathways involved in cell movement and receptor activation...
  66. ENGINEERING INTEGRIN--MEDIATED CELL MIGRATION
    Douglas Lauffenburger; Fiscal Year: 2002
    ..They have also established that individual cell movement speed depends on integrin/ligand binding through cell/substratum adhesiveness, in accord with their model ..
  67. CELL MOVEMENT DURING XENOPUS DEVELOPMENT--METASTASIS
    Karen Symes; Fiscal Year: 2004
    ..It is difficult to directly study cell movement in metastasizing tumors in situ...
  68. BIOCHEMISTRY AND BIOLOGY OF A MYOSIN BINDING PROTEIN
    David Burgess; Fiscal Year: 1992
    ..little is known about how the cell changes the assembly state and localization of myosin during cell movement. Muscle cells have a number of myosin-associated proteins including light and heavy chain kinases, which ..
  69. REGULATION OF CELL MIGRATION IN VASCULAR REMODELING
    Eric Howard; Fiscal Year: 2002
    ..As in other instances of cell movement, smooth muscle cell migration into the neointima involves a regulated series of adhesion and de-adhesion ..
  70. Cell Shape Control of Migration on Biomaterials
    Chia Chi Ho; Fiscal Year: 2006
    ..One major challenge in engineering complex tissues is directional control of cell movement. For example, different cell types assemble in specific patterns to form functional organs, capillaries sprout ..
  71. Molecular Motors in Transport and Signaling by APP
    Virgil Muresan; Fiscal Year: 2009
    ..Recent data suggest that APP is transported to the cell surface by kinesin-I, where it may regulate cell movement, and that its proteolytic cleavage product, Cgamma is transported retrogradely (presumably by cytoplasmic ..