cell compartmentation

Summary

Summary: A partitioning within cells due to the selectively permeable membranes which enclose each of the separate parts, e.g., mitochondria, lysosomes, etc.

Top Publications

  1. ncbi Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover
    Gianni M Di Guglielmo
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Nat Cell Biol 5:410-21. 2003
  2. pmc Complete genome sequence of the marine planctomycete Pirellula sp. strain 1
    F O Glöckner
    Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, D 28359 Bremen, Germany
    Proc Natl Acad Sci U S A 100:8298-303. 2003
  3. ncbi Beyond the sequence: cellular organization of genome function
    Tom Misteli
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 128:787-800. 2007
  4. ncbi Coat proteins and vesicle budding
    R Schekman
    Department of Molecular and Cell Biology, University of California, Berkeley, 94720 3202, USA
    Science 271:1526-33. 1996
  5. pmc Architecture and regulation of the HIV-1 assembly and holding compartment in macrophages
    Sonja Welsch
    EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    J Virol 85:7922-7. 2011
  6. ncbi Organization and regulation of mitogen-activated protein kinase signaling pathways
    T P Garrington
    Program in Molecular Signal Transduction, Division of Basic Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Opin Cell Biol 11:211-8. 1999
  7. pmc Uptake of gentamicin by bullfrog saccular hair cells in vitro
    P S Steyger
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, OR 97201, USA
    J Assoc Res Otolaryngol 4:565-78. 2003
  8. pmc Combined noninvasive imaging and modeling approaches reveal metabolic compartmentation in the barley endosperm
    Hardy Rolletschek
    Leibniz Institut für Pflanzengenetik und Kulturpflanzenforschung, 06466 Gatersleben, Germany
    Plant Cell 23:3041-54. 2011
  9. pmc Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes
    Michele Dardalhon
    Centre National de la Recherche Scientifique, UMR3348 Genotoxic Stress and Cancer, 91405 Orsay, France
    Free Radic Biol Med 52:2254-65. 2012
  10. ncbi HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress
    J Martin-Serrano
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, USA
    Nat Med 7:1313-9. 2001

Research Grants

Detail Information

Publications268 found, 100 shown here

  1. ncbi Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover
    Gianni M Di Guglielmo
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Nat Cell Biol 5:410-21. 2003
    ..Thus, segregation of TGF-beta receptors into distinct endocytic compartments regulates Smad activation and receptor turnover...
  2. pmc Complete genome sequence of the marine planctomycete Pirellula sp. strain 1
    F O Glöckner
    Max Planck Institute for Marine Microbiology, Celsiusstrasse 1, D 28359 Bremen, Germany
    Proc Natl Acad Sci U S A 100:8298-303. 2003
    ..Phylogenetic analysis of all relevant markers clearly affiliates the Planctomycetales to the domain Bacteria as a distinct phylum, but a deepest branching is not supported by our analyses...
  3. ncbi Beyond the sequence: cellular organization of genome function
    Tom Misteli
    National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cell 128:787-800. 2007
    ..Recent insights into the cell biology of genomes have overturned long-held dogmas and have led to new models for many essential cellular processes, including gene expression and genome stability...
  4. ncbi Coat proteins and vesicle budding
    R Schekman
    Department of Molecular and Cell Biology, University of California, Berkeley, 94720 3202, USA
    Science 271:1526-33. 1996
    ..Secretion, which has been viewed as a default pathway, may require sorting and packaging signals on transported molecules to ensure their rapid delivery to the cell surface...
  5. pmc Architecture and regulation of the HIV-1 assembly and holding compartment in macrophages
    Sonja Welsch
    EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    J Virol 85:7922-7. 2011
    ..We conclude that HIV-1 induces the expansion of a complex membranous labyrinth in macrophages in which the virus buds and can be retained, with potential consequences for transmission and immune evasion...
  6. ncbi Organization and regulation of mitogen-activated protein kinase signaling pathways
    T P Garrington
    Program in Molecular Signal Transduction, Division of Basic Sciences, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Curr Opin Cell Biol 11:211-8. 1999
    ..As new MAPK members are defined, determining their organization in kinase modules will be critical in understanding their select role in cellular regulation...
  7. pmc Uptake of gentamicin by bullfrog saccular hair cells in vitro
    P S Steyger
    Oregon Hearing Research Center, Oregon Health and Science University, Portland, OR 97201, USA
    J Assoc Res Otolaryngol 4:565-78. 2003
    ..Thus, GTTR is a valid fluorescent probe with which to investigate the pharmacokinetics and mechanisms of gentamicin accumulation...
  8. pmc Combined noninvasive imaging and modeling approaches reveal metabolic compartmentation in the barley endosperm
    Hardy Rolletschek
    Leibniz Institut für Pflanzengenetik und Kulturpflanzenforschung, 06466 Gatersleben, Germany
    Plant Cell 23:3041-54. 2011
    ..Hence the (13)C-Ala gradient can be used as an in vivo marker for hypoxia. The combination of MRI and metabolic modeling offers opportunities for the noninvasive analysis of metabolic compartmentation in plants...
  9. pmc Redox-sensitive YFP sensors monitor dynamic nuclear and cytosolic glutathione redox changes
    Michele Dardalhon
    Centre National de la Recherche Scientifique, UMR3348 Genotoxic Stress and Cancer, 91405 Orsay, France
    Free Radic Biol Med 52:2254-65. 2012
    ....
  10. ncbi HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress
    J Martin-Serrano
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, USA
    Nat Med 7:1313-9. 2001
    ..Because the Tsg101 is recruited by small, conserved viral sequence motifs, agents that mimic these structures are potential inhibitors of the replication of these lethal human pathogens...
  11. pmc Differences in the endosomal distributions of the two mannose 6-phosphate receptors
    J Klumperman
    Department of Cell Biology, Utrecht University, The Netherlands
    J Cell Biol 121:997-1010. 1993
    ..These data suggest that the two MPRs exit the TGR via the same coated vesicles, but that upon arrival in the endosomes CD-MPR is more rapidly than CI-MPR, segregated into ATV which probably are destined to recycle MPRs to TGR...
  12. pmc Two new Ypt GTPases are required for exit from the yeast trans-Golgi compartment
    G Jedd
    Department of Pharmacological and Physiological Sciences, The University of Chicago, Illinois 60637, USA
    J Cell Biol 137:563-80. 1997
    ..This step might involve budding of vesicles from the trans-Golgi. Alternatively, Ypt31/32p might promote secretion indirectly, by allowing fusion of recycling vesicles with the trans-Golgi compartment...
  13. ncbi Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage
    S Kharbanda
    Division of Cancer Pharmacology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:322-7. 2000
    ..These findings indicate that translocation of SAPK to mitochondria is functionally important for interactions with Bcl-x(L) in the apoptotic response to genotoxic stress...
  14. ncbi ERGIC-53 and traffic in the secretory pathway
    H P Hauri
    Department of Pharmacology, Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Cell Sci 113:587-96. 2000
    ..Understanding these fundamental processes of cell biology will be crucial for the elucidation and treatment of many inherited and acquired diseases, such as cystic fibrosis, Alzheimer's disease and viral infections...
  15. pmc Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division
    Q Tieu
    Section of Molecular and Cellular Biology, University of California Davis, Davis, California 95616, USA
    J Cell Biol 151:353-66. 2000
    ....
  16. ncbi Differential targeting of GSH1 and GSH2 is achieved by multiple transcription initiation: implications for the compartmentation of glutathione biosynthesis in the Brassicaceae
    Andreas Wachter
    Heidelberg Institute of Plant Sciences HIP, INF 360, D 69120 Heidelberg, Germany
    Plant J 41:15-30. 2005
    ..The implications of the results for the compartmentation and regulation of GSH synthesis are discussed...
  17. pmc A Rab GAP cascade defines the boundary between two Rab GTPases on the secretory pathway
    Félix E Rivera-Molina
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 106:14408-13. 2009
    ..GEF cascades working in concert with counter-current GAP cascades could generate a programmed series of Rab conversions responsible for regulating the choreography of membrane traffic...
  18. pmc The SLP1 gene of Saccharomyces cerevisiae is essential for vacuolar morphogenesis and function
    Y Wada
    Department of Biology, Faculty of Science, University of Tokyo, Japan
    Mol Cell Biol 10:2214-23. 1990
    ....
  19. ncbi The protein network of HIV budding
    Uta K von Schwedler
    Department of Biochemistry, University of Utah, Salt Lake City, UT 84132, USA
    Cell 114:701-13. 2003
    ..These studies define a protein network required for human MVB biogenesis and indicate that the entire network participates in the release of HIV and probably many other viruses...
  20. ncbi Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation
    Viacheslav O Nikolaev
    Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK
    Science 327:1653-7. 2010
    ..Thus, the redistribution of beta(2)ARs in heart failure changes compartmentation of cAMP and might contribute to the failing myocardial phenotype...
  21. pmc Zygotically controlled F-actin establishes cortical compartments to stabilize furrows during Drosophila cellularization
    Anna Marie Sokac
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Cell Sci 121:1815-24. 2008
    ....
  22. pmc The cell cycle of the planctomycete Gemmata obscuriglobus with respect to cell compartmentalization
    Kuo Chang Lee
    School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia
    BMC Cell Biol 10:4. 2009
    ..It was therefore of interest to examine the cell division cycle in G. obscuriglobus and the process of nucleoid distribution and nuclear body formation during division in this planctomycete bacterium via light and electron microscopy...
  23. ncbi Small GTP-binding protein associated with Golgi cisternae
    B Goud
    Unité de Génétique Somatique URA CNRS 361, Institut Pasteur, Paris, France
    Nature 345:553-6. 1990
    ..By immunolabelling and electron microscopy, Rab6p appears to be concentrated predominantly on the medial and trans cisternae and distributed over their entire surface...
  24. pmc An Arabidopsis endo-1,4-beta-D-glucanase involved in cellulose synthesis undergoes regulated intracellular cycling
    Stephanie Robert
    Laboratoire de Biologie Cellulaire, Institut Jean Pierre Bourgin, Institut National de la Recherche Agronomique, Versailles, France
    Plant Cell 17:3378-89. 2005
    ..These observations demonstrate that the deposition of cellulose, like chitin synthesis in yeast, involves the regulated intracellular cycling of at least one enzyme required for its synthesis...
  25. ncbi Increased intracellular H₂O₂ availability preferentially drives glutathione accumulation in vacuoles and chloroplasts
    Guillaume Queval
    Institut de Biologie des Plantes, UMR8618 CNRS, Batiment 630, Université de Paris Sud 11, 91405 Orsay Cedex, France
    Plant Cell Environ 34:21-32. 2011
    ..The data are used to estimate compartment-specific glutathione concentrations under optimal and oxidative stress conditions, and the implications for redox homeostasis and signalling are discussed...
  26. pmc Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells
    Jatin M Vyas
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    J Immunol 178:7199-210. 2007
    ..In addition to its association with microtubules, endolysosomal tubules follow the plus ends of microtubules as visualized in primary DCs expressing end binding protein 1 (EB1)-enhanced GFP...
  27. ncbi Cell surface organization by the membrane skeleton
    A Kusumi
    Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba 3 8 1, Meguro ku, Tokyo 153, Japan
    Curr Opin Cell Biol 8:566-74. 1996
    ....
  28. pmc Rab-A2 and Rab-A3 GTPases define a trans-golgi endosomal membrane domain in Arabidopsis that contributes substantially to the cell plate
    Cheung Ming Chow
    Department of Plant Sciences, University of Oxford, Oxford OX1 3RB, United Kingdom
    Plant Cell 20:101-23. 2008
    ..Despite the unique features of plant cytokinesis, membrane traffic to the division plane exhibits surprising molecular similarity across eukaryotic kingdoms in its reliance on Ypt3/Rab11/Rab-A GTPases...
  29. pmc Rab22a regulates the sorting of transferrin to recycling endosomes
    Javier G Magadán
    Laboratorio de Biologia Celular y Molecular, Instituto de Histologia y Embriologia IHEM CONICET, Facultad de Ciencias Medicas, Universidad Nacional de Cuyo, Casilla de Correo 56, 5500 Mendoza, Argentina
    Mol Cell Biol 26:2595-614. 2006
    ..We speculate that Rab22a controls the transport of the transferrin receptor from sorting to recycling endosomes...
  30. pmc Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity
    W Görner
    Vienna Biocenter, Institut für Biochemie und Molekulare Zellbiologie der Universität Wien and Ludwig Boltzmann Forschungsstelle für Biochemie, A 1030 Wien, Austria
    Genes Dev 12:586-97. 1998
    ..We propose stress and cAMP-regulated intracellular localization of Msn2p to be a key step in STRE-dependent transcription and in the general stress response...
  31. ncbi Plectin-RACK1 (receptor for activated C kinase 1) scaffolding: a novel mechanism to regulate protein kinase C activity
    Selma Osmanagic-Myers
    Institute of Biochemistry and Molecular Cell Biology, University of Vienna, Vienna Biocenter, Dr Bohrgasse 9, A 1030 Vienna, Austria
    J Biol Chem 279:18701-10. 2004
    ..We propose a previously unrecognized function of plectin as cytoskeletal regulator of PKC signaling, and possibly other signaling events, through sequestration of the scaffolding protein RACK1...
  32. ncbi Characterization of E-cadherin endocytosis in isolated MCF-7 and chinese hamster ovary cells: the initial fate of unbound E-cadherin
    Andrew D Paterson
    School for Biomedical Science, The University of Queensland, St Lucia, Brisbane, Australia 4072
    J Biol Chem 278:21050-7. 2003
    ..Taken with earlier reports, this suggests the possibility that multiple pathways exist for E-cadherin entry into cells that are likely to reflect cell context and regulation...
  33. pmc Rab27a: A key to melanosome transport in human melanocytes
    P Bahadoran
    Unité de Recherches sur la Biologie et la Physiopathologie de la Peau, Institut National de la Sante et de la Recherche Medicale U385, Faculte de Medecine, 06107 Nice Cedex 2, France
    J Cell Biol 152:843-50. 2001
    ..These results identify Rab27a as a key component of vesicle transport machinery in melanocytes...
  34. pmc Endosomal entry regulates Notch receptor activation in Drosophila melanogaster
    Thomas Vaccari
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    J Cell Biol 180:755-62. 2008
    ....
  35. pmc Infectious HIV-1 assembles in late endosomes in primary macrophages
    Annegret Pelchen-Matthews
    Cell Biology Unit, Medical Research MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK
    J Cell Biol 162:443-55. 2003
    ..This notion has significant implications for understanding the biology of HIV and its cell-cell transmission...
  36. pmc Hydrogen peroxide fluxes and compartmentalization inside growing Escherichia coli
    L C Seaver
    Department of Microbiology, University of Illinois, Urbana, Illinois 61801, USA
    J Bacteriol 183:7182-9. 2001
    ....
  37. pmc EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking
    Ian G Mills
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    J Cell Biol 160:213-22. 2003
    ....
  38. ncbi Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments
    P Chavrier
    European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    Cell 62:317-29. 1990
    ..These findings provide evidence that members of the YPT1/SEC4 subfamily of GTP binding proteins are localized to specific exocytic and endocytic subcompartments in mammalian cells...
  39. ncbi The biogenesis of multivesicular endosomes
    Jean Gruenberg
    Department of Biochemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland
    Nat Rev Mol Cell Biol 5:317-23. 2004
  40. pmc Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments
    H Plutner
    Department of Molecular and Cellular Biology, Scripps Research Institute, La Jolla, California 92037
    J Cell Biol 115:31-43. 1991
    ..We suggest that rab1b may provide a common link between upstream and downstream components of the vesicular fission and fusion machinery functioning in early compartments of the secretory pathway...
  41. pmc Cytoplasmic cAMP concentrations in intact cardiac myocytes
    Radu V Iancu
    Dept of Physiology and Biophysics, Case Western Reserve Univ, 10900 Euclid Ave, Cleveland, OH 44106 4970, USA
    Am J Physiol Cell Physiol 295:C414-22. 2008
    ..This allows receptor stimulation to regulate cAMP activity over concentration ranges appropriate for modulating both higher (e.g., PKA) and lower affinity (e.g., Epac) effectors...
  42. pmc Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association
    A Wolven
    Program in Molecular Biology, Cornell University Graduate School of Medical Sciences, New York, New York 10021, USA
    Mol Biol Cell 8:1159-73. 1997
    ..These studies establish that the palmitoylated SH4 sequence of Fyn can be used to specifically target proteins to the plasma membrane in a reversible manner...
  43. ncbi Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras
    C Song
    Department of Physiology II, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 276:2752-7. 2001
    ..These results indicate that Ras directly regulates phosphoinositide breakdown through membrane targeting of PLCepsilon...
  44. ncbi Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway
    T M Harding
    Section of Microbiology, University of California, Davis, California 95616, USA
    J Biol Chem 271:17621-4. 1996
    ....
  45. pmc The plant vesicle-associated SNARE AtVTI1a likely mediates vesicle transport from the trans-Golgi network to the prevacuolar compartment
    H Zheng
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, Michigan 48824, USA
    Mol Biol Cell 10:2251-64. 1999
    ..We propose that AtVTI1a functions as a v-SNARE responsible for targeting AtELP-containing vesicles from the trans-Golgi network to the PVC, and that AtVTI1b is involved in a different membrane transport process...
  46. ncbi The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure
    Fulvio Reggiori
    Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Cell 6:79-90. 2004
    ..We postulate that Atg9 employs a recycling system mechanistically similar to that used at yeast early and late endosomes...
  47. ncbi Large-scale chromatin organization and the localization of proteins involved in gene expression in human cells
    Pernette J Verschure
    Swammerdam Institute for Life Sciences, BioCentrum Amsterdam, University of Amsterdam, Amsterdam, The Netherlands
    J Histochem Cytochem 50:1303-12. 2002
    ..Our data support a conceptually simple model for the functional organization of interphase nuclei...
  48. pmc The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein
    P Cupers
    Center for Human Genetics, Neuronal Cell Biology Group, Flanders Interuniversity Institute for Biotechnology and Catholic University of Leuven, B-3000 Leuven, Belgium
    J Cell Biol 154:731-40. 2001
    ..Our data confirm the "spatial paradox" and raise several questions regarding the PS1 is gamma-secretase hypothesis...
  49. pmc Regeneration of a lytic central vacuole and of neutral peripheral vacuoles can be visualized by green fluorescent proteins targeted to either type of vacuoles
    G P Di Sansebastiano
    Laboratoire de Biochimie, Institut de Botanique, , Rue Emile-Argand 9, , Switzerland
    Plant Physiol 126:78-86. 2001
    ..Only later, once the regeneration of the CV was completed, the content of peripheral storage vacuoles could be seen to appear in the CV of a third of the cells, apparently by heterotypic fusion...
  50. pmc The human CAN protein, a putative oncogene product associated with myeloid leukemogenesis, is a nuclear pore complex protein that faces the cytoplasm
    D Kraemer
    Laboratory of Cell Biology, Rockefeller University, Howard Hughes Medical Institute, New York, NY 10021
    Proc Natl Acad Sci U S A 91:1519-23. 1994
    ..In agreement with previously proposed nomenclature for nucleoporins, we propose the alternative term nup214 (nucleoporin of 214 kDa) for the CAN protein...
  51. ncbi Structure and mechanisms of a protein-based organelle in Escherichia coli
    Shiho Tanaka
    Department of Chemistry and Biochemistry, University of California Los Angeles, 611 Charles Young Drive East, Los Angeles, CA 90095, USA
    Science 327:81-4. 2010
    ..Together these structures give mechanistic insight into bacterial microcompartments...
  52. pmc Brittle-1, an adenylate translocator, facilitates transfer of extraplastidial synthesized ADP--glucose into amyloplasts of maize endosperms
    J C Shannon
    Department of Horticulture, 102 Tyson Building, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Plant Physiol 117:1235-52. 1998
    ..The importance of the BT1 translocator in starch accumulation in maize endosperms is demonstrated by the severely reduced starch content in bt1 mutant kernels...
  53. pmc Divergent regulation of protein synthesis in the cytosol and endoplasmic reticulum compartments of mammalian cells
    Samuel B Stephens
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Biol Cell 19:623-32. 2008
    ..These findings identify a role for the ER in global protein synthesis, and they suggest models where compartmentalization of the tRNA acylation/deacylation cycle contributes to the regulation of global protein synthesis rates...
  54. ncbi The contribution of nuclear compartmentalization to gene regulation
    Maria Carmo-Fonseca
    Institute of Molecular Medicine, Faculty of Medicine, University of Lisbon, Av Prof Egas Moniz, 1649 028 Lisbon, Portugal
    Cell 108:513-21. 2002
    ..This article discusses current views on the origins of nuclear compartments and their roles in gene expression...
  55. pmc Gag3p, an outer membrane protein required for fission of mitochondrial tubules
    P Fekkes
    University of California, San Diego, Division of Biology, Section of Cell and Developmental Biology, La Jolla, California 92093, USA
    J Cell Biol 151:333-40. 2000
    ..These results indicate that Gag3p plays a distinct role on the mitochondrial surface to mediate the fission of mitochondrial tubules...
  56. pmc Caveolae and sorting in the trans-Golgi network of epithelial cells
    P Dupree
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 12:1597-605. 1993
    ..This connection is confirmed by the recent finding that the amino acid sequence of VIP21 is almost identical to that of caveolin, a protein previously localized to caveolae...
  57. ncbi Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum
    Manoj T Duraisingh
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Cell 121:13-24. 2005
    ..Together, this implies that locus repositioning and heterochromatic silencing play important roles in the epigenetic regulation of virulence genes in P. falciparum...
  58. pmc DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding
    Y Zeng
    Department of Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Mol Cell Biol 19:7410-9. 1999
    ..These results indicate that 14-3-3 binding contributes to the nuclear exclusion of Cdc25 and that the nuclear exclusion of Cdc25 is required for a normal checkpoint response to both damaged and unreplicated DNA...
  59. pmc Lack of beta 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts
    R Fassler
    Max Planck Institute for Biochemistry, Martinsried, Germany
    J Cell Biol 128:979-88. 1995
    ..This will allow studies of the consequences of beta 1 integrin deficiency in several in vivo situations...
  60. pmc The compartmentalized bacteria of the planctomycetes-verrucomicrobia-chlamydiae superphylum have membrane coat-like proteins
    Rachel Santarella-Mellwig
    European Molecular Biology Laboratory, Heidelberg, Germany
    PLoS Biol 8:e1000281. 2010
    ..Our results demonstrate similarities between bacterial and eukaryotic compartmentalization machinery, suggesting that the bacterial PVC superphylum contributed significantly to eukaryogenesis...
  61. pmc Isolation of yeast mutants defective in protein targeting to the vacuole
    V A Bankaitis
    Proc Natl Acad Sci U S A 83:9075-9. 1986
    ..The vpt mutants should provide useful information pertaining to the mechanisms by which yeast cells regulate vacuolar protein traffic...
  62. ncbi Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments
    Inger Øynebråten
    LIIPAT, Institute of Pathology, Rikshospitalet, N 0027 Oslo, Norway
    Blood 104:314-20. 2004
    ..In conclusion, we propose that rapid release of chemokines is restricted to those primarily recruiting leukocytes of the innate immune system, and that their storage in ECs is not restricted to the WPB compartment...
  63. ncbi Spatial coordination of cytokinetic events by compartmentalization of the cell cortex
    Jeroen Dobbelaere
    Institute of Biochemistry, Swiss Federal Institute of Technology, ETH Honggerberg, 8093 Zurich, Switzerland
    Science 305:393-6. 2004
    ..In turn, such factors were required for actomyosin ring function and membrane abscission. Thus, a specialized cortical compartment ensures the spatial coordination of cytokinetic events...
  64. ncbi Structure of the PduU shell protein from the Pdu microcompartment of Salmonella
    Christopher S Crowley
    University of California Los Angeles Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
    Structure 16:1324-32. 2008
    ..In view of the hypothesis that microcompartment metabolites diffuse across the outer shell through these pores, the unique structure of PduU suggests the possibility of a special functional role...
  65. pmc Phylum Verrucomicrobia representatives share a compartmentalized cell plan with members of bacterial phylum Planctomycetes
    Kuo Chang Lee
    School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, Queensland 4072, Australia
    BMC Microbiol 9:5. 2009
    ..Based on the postulated superphylum relationship, we hypothesized that members of the two separate phyla Planctomycetes and Verrucomicrobia might share a similar ultrastructure plan differing from classical prokaryote organization...
  66. pmc Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release
    Tanja Wucherpfennig
    Max Planck Institut für molekulare Zellbiologie und Genetik, Dresden, Germany
    J Cell Biol 161:609-24. 2003
    ..Conversely, Rab5 overexpression increases the release efficacy. Therefore, the Rab5-dependent trafficking pathway plays an important role for synaptic performance...
  67. pmc A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell
    T C Rich
    Department of Physiology and Biophysics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 98:13049-54. 2001
    ..The decline in cAMP levels near the membrane was prevented by pretreatment with phosphodiesterase inhibitors. These data demonstrate that spatially and temporally distinct cAMP signals can coexist within simple cells...
  68. ncbi A platform for compartmentalized protein synthesis: protein translation and translocation in the ER
    Christopher V Nicchitta
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Opin Cell Biol 14:412-6. 2002
    ..A hypothesis identifying the endoplasmic reticulum as a site of mRNA localization and compartmentalized protein synthesis has been suggested...
  69. ncbi The structural and mechanistic basis for recycling of Rab proteins between membrane compartments
    R S Goody
    Abteilung Physikalische Biochemie, Max Planck Institut fur molekulare Physiologie, Otto Hahn Strasse 11, 44227, Dortmund, Germany
    Cell Mol Life Sci 62:1657-70. 2005
    ..Here, the structural and mechanistic basis of events occurring in Rab delivery and cycling, and the differences between REP and GDI are discussed on the basis of recent advances in the field...
  70. ncbi Introns and the origin of nucleus-cytosol compartmentalization
    William Martin
    Institute of Botany III, University of Dusseldorf, D 40225 Dusseldorf, Germany
    Nature 440:41-5. 2006
    ..The rapid, fortuitous spread of introns following the origin of mitochondria is adduced as the selective pressure that forged nucleus-cytosol compartmentalization...
  71. ncbi Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting
    Markus Babst
    Department of Cellular and Molecular Medicine and Howard Hughes Medical Institute, School of Medicine, University of California, San Diego, La Jolla 92093, USA
    Dev Cell 3:271-82. 2002
    ..The Vps2-Vps24 subcomplex binds to the Vps20-Snf7 complex and thereby serves to recruit additional cofactors to this site of protein sorting. We provide evidence for a role for ESCRT-III in sorting and/or concentration of MVB cargoes...
  72. pmc Phospholipids undergo hop diffusion in compartmentalized cell membrane
    Takahiro Fujiwara
    Kusumi Membrane Organizer Project, Exploratory Research for Advanced Technology Organization, Japan Science and Technology Corporation, Nagoya 460 0012, Japan
    J Cell Biol 157:1071-81. 2002
    ..We propose that various transmembrane proteins anchored to the actin-based membrane skeleton meshwork act as rows of pickets that temporarily confine phospholipids...
  73. pmc Cessation of rapid late endosomal tubulovesicular trafficking in Niemann-Pick type C1 disease
    M Zhang
    Lipid Cell Biology Section and Cell Biochemistry Section, National Institute of Diabetes and Digestive and Kidney Diseases, and Developmental and Metabolic Neurology Branch, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:4466-71. 2001
    ..We conclude that the neuropathology and cellular lysosomal lipid accumulation in NPC1 disease results, at least in part, from striking defects in late endosomal tubulovesicular trafficking...
  74. ncbi Spatial and temporal regulation of 3-phosphoinositides by PI 3-kinase and PTEN mediates chemotaxis
    Satoru Funamoto
    Section of Cell and Developmental Biology, Division of Biology, Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 109:611-23. 2002
    ..These findings provide evidence that differential subcellular localization and activation of PI3K and PTEN is required for proper chemotaxis...
  75. pmc Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones
    B H Kang
    Prostate Cancer Discovery and Development Program, Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Oncogene 28:3681-8. 2009
    ....
  76. ncbi Regulation of CDC25B phosphatases subcellular localization
    N Davezac
    LBCMCP CNRS UMR5088, Universite Paul Sabatier, Toulouse, France
    Oncogene 19:2179-85. 2000
    ..The subcellular localization of CDC25B is therefore dependent on the combined effects of a nuclear localization signal, a nuclear export signal and on the interaction with 14-3-3 proteins...
  77. ncbi Compartmentalized synthesis and degradation of proteins in neurons
    Oswald Steward
    Reeve Irvine Research Center and Department of Anatomy Neurobiology, College of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Neuron 40:347-59. 2003
    ..Here, we summarize what is known about local synthesis and degradation of protein in dendrites and axons, highlighting key unresolved questions...
  78. pmc Examination of Listeria monocytogenes intracellular gene expression by using the green fluorescent protein of Aequorea victoria
    N E Freitag
    Department of Immunology and Microbiology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Infect Immun 67:1844-52. 1999
    ..These results emphasize the ability of L. monocytogenes to sense the different host cell compartment environments encountered during the course of infection and to regulate virulence gene expression in response...
  79. ncbi Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier
    P A Takizawa
    Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    Science 290:341-4. 2000
    ..These results indicate that yeast creates distinct plasma membrane compartments, as has been described in neurons and epithelial cells...
  80. ncbi Vam3p, a new member of syntaxin related protein, is required for vacuolar assembly in the yeast Saccharomyces cerevisiae
    Y Wada
    Department of Biology, Graduate School of Arts and Sciences, University of Tokyo, Komaba, Meguro ku, Japan
    J Cell Sci 110:1299-306. 1997
    ..We conclude from these observations that Vam3p is a novel member of syntaxin in the vacuoles and it provides the t-SNARE function in a late step of the vacuolar assembly...
  81. pmc Specific retrieval of the exocytic SNARE Snc1p from early yeast endosomes
    M J Lewis
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    Mol Biol Cell 11:23-38. 2000
    ..We propose that these represent early endosomes in which sorting of Snc1p and late Golgi proteins occurs, and that transport can occur directly from them to the Golgi apparatus...
  82. pmc Mechanism of cargo selection in the cytoplasm to vacuole targeting pathway
    Takahiro Shintani
    University of Michigan, Department of Molecular, Cellular, and Developmental Biology, Ann Arbor 48109, USA
    Dev Cell 3:825-37. 2002
    ....
  83. ncbi To be or not to be in the nucleolus
    M Carmo-Fonseca
    Institute of Histology and Embryology, Faculty of Medicine, University of Lisbon, Av Prof Egas Moniz 1649 028 Lisbon, Portugal
    Nat Cell Biol 2:E107-12. 2000
    ..One of these, the nucleolus, has recently attracted much attention. The emerging view is that molecular confinement in the nucleolus actively contributes to the control of cellular survival and proliferation...
  84. ncbi The intracellular localization of messenger RNAs
    D St Johnston
    Wellcome Trust Cancer Research Campaign Institute, University of Cambridge, England
    Cell 81:161-70. 1995
    ..Indeed, there are already several examples where the direct linkage between translational control and localization has been demonstrated, and these are discussed in the accompanying review by Curtis et al. (1995)...
  85. pmc Roles for the recycling endosome, Rab8, and Rab11 in hantavirus release from epithelial cells
    Regina K Rowe
    Department of Molecular Microbiology, Washington University in St Louis School of Medicine, St Louis, MO 63110, USA
    Virology 382:239-49. 2008
    ..These data implicate the recycling endosome and the Rab proteins associated with vesicular transport to or from this intracellular organelle as an important pathway for hantavirus trafficking to the plasma membrane...
  86. pmc The AP-1A and AP-1B clathrin adaptor complexes define biochemically and functionally distinct membrane domains
    HEIKE FOLSCH
    Department of Cell Biology, Ludwig Institute for Cancer Research, Yale University School of Medicine, New Haven, CT 06520, USA
    J Cell Biol 163:351-62. 2003
    ..Thus, despite the similarity of the two AP-1 complexes, AP-1A and AP-1B exhibit great specificity for endosomal transport versus cell polarity...
  87. pmc Box C/D small nucleolar RNA trafficking involves small nucleolar RNP proteins, nucleolar factors and a novel nuclear domain
    C Verheggen
    IGMM, IFR 24, UMR 5535 du CNRS, 34293 Montpellier Cedex 5, France
    EMBO J 20:5480-90. 2001
    ..We conclude that snoRNP assembly occurs either in the nucleoplasm, or during transit of snoRNAs through the NB, followed by routing of the complete snoRNP to functional sites of ribosome synthesis...
  88. pmc Rab27a regulates the peripheral distribution of melanosomes in melanocytes
    A N Hume
    Cell and Molecular Biology Section, Division of Biomedical Sciences, London, United Kingdom
    J Cell Biol 152:795-808. 2001
    ..These results, together with recent data implicating myosinVa in the peripheral capture of melanosomes, suggest that Rab27a is necessary for the recruitment of myosinVa, so allowing the peripheral retention of melanosomes in melanocytes...
  89. ncbi Localization of protein kinases by anchoring proteins: a theme in signal transduction
    D Mochly-Rosen
    Department of Molecular Pharmacology, School of Medicine, Stanford University, CA 94305 5332, USA
    Science 268:247-51. 1995
    ....
  90. ncbi Developmental loss and resistance to MPTP toxicity of dopaminergic neurones in substantia nigra pars compacta of gamma-synuclein, alpha-synuclein and double alpha/gamma-synuclein null mutant mice
    Darren C Robertson
    Department of Preclinical Veterinary Sciences, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, Scotland, UK
    J Neurochem 89:1126-36. 2004
    ....
  91. ncbi Targeting of CD45 protein tyrosine phosphatase activity to lipid microdomains on the T cell surface inhibits TCR signaling
    Xiao He
    Howard Hughes Medical Institute, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, USA
    Eur J Immunol 32:2578-87. 2002
    ....
  92. ncbi EphA4 is not required for Purkinje cell compartmentation
    Sana D Karam
    Department of Physiology and Biophysics, University of Washington, P O Box 357290, Seattle, WA 98195, USA
    Brain Res Dev Brain Res 135:29-38. 2002
    ..B: Biol. Sci. 355 (2000) 993), we analyzed the effect of a null mutation of the EphA4 gene on Purkinje cell compartmentation. Using well characterized markers of Purkinje cell compartmentation in both the developing and the adult ..
  93. ncbi The assembly of CD1e is controlled by an N-terminal propeptide which is processed in endosomal compartments
    Blandine Maitre
    INSERM, U 725 Biology of Human Dendritic Cells, Strasbourg, France
    Biochem J 419:661-8. 2009
    ..Comparison of CD1e cDNAs from different mammalian species indicates that the CD1e propeptide is conserved during evolution, suggesting that it may also optimize the generation of CD1e molecules in other species...
  94. ncbi Asymmetric mitotic segregation of the yeast spindle pole body
    E A Vallen
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton, New Jersey 08544 1014
    Cell 69:505-15. 1992
    ..The localization domains correspond to two functional domains required for SPB duplication. We suggest that KAR1 is anchored to the nuclear envelope and interacts with at least one other SPB component during the cell cycle...
  95. ncbi The endocytic network in plants
    Jozef Samaj
    Institute of Cellular and Molecular Botany, University of Bonn, Kirschallee 1, D 53115 Bonn, Germany
    Trends Cell Biol 15:425-33. 2005
    ..Last, recent results indicate that the trans Golgi network in plants should be considered an integral part of the endocytic network...
  96. ncbi Rab3D redistribution and function in rat parotid acini
    Danieele Nguyen
    Division of Digestive Diseases, State University of New York Downstate Medical Center, Brooklyn, New York 11203, USA
    J Cell Physiol 197:400-8. 2003
    ..The fact that both wild-type Rab3D and the GTP-binding mutant inhibit amylase release suggests that binding of Rab3D to the membrane is not essential for secretory inhibition...
  97. ncbi Lipid rafts mediate the synaptic localization of alpha-synuclein
    Doris L Fortin
    Department of Neurology, Graduate Programs in Biomedical Sciences, Cell Biology and Neuroscience, University of California San Francisco School of Medicine, San Francisco, California 94143 2140, USA
    J Neurosci 24:6715-23. 2004
    ....
  98. ncbi Interactions between biosynthesis, compartmentation and transport in the control of glutathione homeostasis and signalling
    Graham Noctor
    Institut de Biotechnologie des Plantes, Bât 630 Université Paris VII, 91405 Orsay Cedex, France
    J Exp Bot 53:1283-304. 2002
    ..All these factors must be considered in order to evaluate the significance of glutathione as a signalling component during development, abiotic stress, or pathogen attack...
  99. ncbi A genomic perspective on membrane compartment organization
    J B Bock
    Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University School of Medicine, California 94305-5426, USA
    Nature 409:839-41. 2001
    ..All families were expanded in humans, where we find 35 SNAREs, 60 Rabs and 53 coat complex subunits. In addition, we were able to resolve the SNARE class of proteins into four distinct subfamilies...
  100. ncbi Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae
    J G Cook
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3202, USA
    Genes Dev 10:2831-48. 1996
    ..Collectively, these findings indicate that Dig1, and most likely Dig2, are physiological substrates of Kssl and suggest that they regulate Ste12 function by direct protein-protein interaction...
  101. pmc Insulin resistance, diabetes, and the insulin-regulated trafficking of GLUT-4
    D E James
    Center for Molecular Biology and Biotechnology, University of Queensland, St Lucia, Brisbane, Australia
    J Cell Biol 126:1123-6. 1994

Research Grants66

  1. The Role of Actin Remodeling in Membrane Fusion Microdomains
    William Wickner; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Regulated membrane fusion is essential for cell compartmentation and growth, neurotransmission, and hormone release...
  2. GENESIS OF CELL PATTERN IN CEREBELLUM AND STRIATUM
    Michael Edwards; Fiscal Year: 1991
    ..changes in the loss and deployment of radial glial are principle factors in the formation of patterns of cell compartmentation. These studies will make use of (3H)thymidine autoradiography to identify cells by birth date, light and ..
  3. Axon Regeneration after Spinal Cord Injury in Mice
    Oswald Steward; Fiscal Year: 2009
    ..Together, these studies will provide a critical data base regarding the growth capacity of cortico-spinal tract axons in mice, which will be essential for future studies involving genetically modified mice. ..
  4. Identification of Histone Gene Regulatory Sequences
    Gary Stein; Fiscal Year: 2006
    ..These studies will elucidate parameters of growth control that mediate competency for proliferation and cell cycle progression. [unreadable] [unreadable]..
  5. EICOSANOIDS AND LUNG MACROPHAGE ANTIMICROBIAL MECHANISMS
    Marc Peters Golden; Fiscal Year: 2008
    ..EP4 ligation. These proposed studies will provide fundamental insights into AM antimicrobial function, and a clinically relevant framework for understanding and modulating innate immunity in the lung. ..
  6. Postdoctoral Training Program in Neural Regeneration
    Oswald Steward; Fiscal Year: 2005
    ....
  7. LOCALIZATION OF MRNAS AT SYNAPTIC SITES ON DENDRITES
    Oswald Steward; Fiscal Year: 2011
    ..These studies will provide novel insights into the basic mechanisms underlying information storage in the brain and neurological disorders that disrupt this fundamental mechanism, including Fragile-X Mental Retardation Syndrome. ..
  8. GENETIC APPROACH TO CNS REGENERATION RESEARCH
    Oswald Steward; Fiscal Year: 2001
    ....
  9. Summer Training Program in Neuroscience
    Oswald Steward; Fiscal Year: 2006
    ..Where appropriate, trainees will be encouraged to present their results at national meetings, and support will be provided for students to attend such meetings. [unreadable] [unreadable]..
  10. INTRANUCLEAR TRAFFICKING OF BONE TRANSCRIPTION FACTORS
    Gary Stein; Fiscal Year: 2001
    ....
  11. Molecular Crosstalk in Intracellular Signaling Netoworks
    JASON HAUGH; Fiscal Year: 2006
    ..Finally, for conditions found to perturb the signaling network, the corresponding effects on cell proliferation and survival will be assessed. ..
  12. GENETIC DISSECTION OF TOXOPLASMA GONDII
    David Roos; Fiscal Year: 2008
    ..In addition to their value for the analysis of folate metabolism and drug resistance, these tools should be broadly applicable to other studies on the biology and biochemistry of Toxoplasma. ..
  13. Develop Effective Inhibitors of Anthrax Lethal Factor
    Alex Strongin; Fiscal Year: 2006
    ..We are confident that the resulting LF antagonist(s) will efficiently and safely provide the therapy that is so urgently required. ..
  14. Gene networks specifying cell lineages in a polychaete
    Bruce Bowerman; Fiscal Year: 2007
    ..Newly discovered and conserved loci will also be studied in C. elegans and Drosophila. [unreadable] [unreadable]..
  15. DEVELOPMENTAL CELL BIOLOGY OF DENDRITIC CELLS
    Ira Mellman; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  16. Molecular Genetic Analysis of Neurodegeneration
    Nancy Bonini; Fiscal Year: 2007
    ....
  17. Raft/Caveolar Mechanisms in Pulmonary Hypertension
    PRAVIN SEHGAL; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  18. Feasibility of Hemin-Based Therapy in Experimental Acute Pancreatitis
    M Omary; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  19. Inverted two photon laser scanning microscope for host defense
    Michael Dustin; Fiscal Year: 2008
    ..The impact on public health will be to develop better strategies to fight infections and reduce the incidence of pathogen triggered autoimmunity. [unreadable] [unreadable] [unreadable]..
  20. Beta/Gamma Subunit Heterogeniety in G Proteins
    Janet D Robishaw; Fiscal Year: 2010
    ....
  21. MT1-MMP pericellular proteolysis in malignancy
    Alex Strongin; Fiscal Year: 2009
    ..The results of these experiments have a very high probability of providing an effective means to regulate the MT1-MMP function in the setting of the disease. ..
  22. cAMP Phosphodiesterase and Lung Endothelial Cell Permeability
    Thomas C Rich; Fiscal Year: 2010
    ..Here we propose to determine whether pharmacological and molecular inhibitors of a specific protein, phosphodiesterase type 7, prevent increases in endothelial permeability in these arteries, and hence, make breathing easier. ..
  23. REGULATION OF PROTEIN TURNOVER IN SEPSIS
    Scot R Kimball; Fiscal Year: 2010
    ....
  24. Lipid Rafts and EGF Receptor Function
    LINDA JOY PIKE; Fiscal Year: 2010
    ....
  25. The Multi-Cellular Basis of Urate-induced Arthropathies
    PAUL NACCACHE; Fiscal Year: 2009
    ..The results will further our understanding of the basis of various inflammatory reactions, and therefore also potentially provide innovative clues as to their therapeutic control. ..
  26. NADPH oxidase and pancreatic cancer cell survival
    Anna Gukovskaya; Fiscal Year: 2009
    ....
  27. IMMUNOPATHOGENESIS OF PSORIASIS
    Brian Nickoloff; Fiscal Year: 2009
    ....
  28. Endothelial Function in the Cerebral Circulation
    Frank Faraci; Fiscal Year: 2009
    ..These studies should provide new insight into mechanisms of cerebral vascular protection during hypertension. ..
  29. The role of Cyclin E in growth control and tumorogenesis
    Steven Reed; Fiscal Year: 2008
    ..It is hoped that insights gained from understanding these fundamental mechanisms of oncogenesis will lead to new approaches to cancer prevention and therapy. ..
  30. Mg2+ homeostasis in liver cells treated with EtOH
    Andrea Romani; Fiscal Year: 2009
    ....
  31. Physiological Modulators of Cytochrome Oxidase Function
    Narayan Avadhani; Fiscal Year: 2006
    ..The overall goal is to determine the molecular basis of H89 mediated protection against ischemic injury to the myocardium. ..
  32. Functional similarities in renal and cochlear epithelia
    PETER STEYGER; Fiscal Year: 2004
    ....
  33. THE S. CEREVISIAE S PHASE CHECKPOINT
    Steven Reed; Fiscal Year: 2003
    ....
  34. 2004 Interfacial Biology in Water
    Gerald Pollack; Fiscal Year: 2004
    ..Because the subject of water is central to behavior of all biological systems, support from the NIH is being requested to conduct this meeting. ..
  35. BCL2 AND BECLIN AND ALPHAVIRUS PATHOGENESIS
    Beth Levine; Fiscal Year: 2003
    ..The proposed studies will provide novel insights into host cellular mechanisms that regulate whether neurons live or die in responses to viral infection. ..
  36. CORECEPTOR MODIFICATION OF TCR TYROSINE KINASE SIGNALS
    M Miceli; Fiscal Year: 2003
    ....
  37. Molecular and Functional Genomics of Plasmodium
    Lawrence Bergman; Fiscal Year: 2004
    ..Again, the rodent malaria model will provide certain advantage in conducting gene expression profiling of parasites replicating in vivo. A variety of investigations will be aided by availability of such microarrays. ..
  38. Cell Biology of the Immune Response
    Ira Mellman; Fiscal Year: 2003
    ..4) To explore how the cellular basis of the immune response contributes to the pathogenecity of and potential immunological therapy for cancer and infectious disease. ..
  39. SCIEX 4000 QTRAP Mass Spectrometer
    Yusuf Hannun; Fiscal Year: 2008
    ..Strong institutional commitment ensures long term operation and maintenance of the requested instrument and overall facility. [unreadable] [unreadable] [unreadable]..
  40. Redox control of Nrf2/ARE by thioredoxin and GSH
    Jason Hansen; Fiscal Year: 2005
    ..The roles of GSH and cytosolic and nuclear TRX during NRF2 activation and binding will provide an essential foundation for future developmental toxicology. ..
  41. Metabolic effects of chemical interactions in toxicity
    Dean Jones; Fiscal Year: 2005
    ....
  42. Actin Organization and Polarization
    Liza Pon; Fiscal Year: 2005
    ..The studies proposed are designed to fill that gap. ..
  43. Spinal Opioid Release in Nociception
    Juan Carlos Marvizon; Fiscal Year: 2008
    ..The neural pathways involved will be studied using selective spinal cord lesions. ..
  44. Distribution and Role of CaMKII in Mouse Olfactory Bulb
    Dong Jing Zou; Fiscal Year: 2003
    ..In particular, we will investigate whether CaMKII activity regulates the development of granule cells, the most abundant neurons in the olfactory bulb. ..
  45. LOCALIZATION OF THE GOLGI COMPLEX
    Suzanne Pfeffer; Fiscal Year: 2001
    ....
  46. ANALYSIS OF GOLGI MEMBRANE PROTEIN LOCALIZATION IN YEAST
    Steven Nothwehr; Fiscal Year: 2003
    ..Finally, several genes have been identified in genetic screens as defective in Golgi retention of proteins, and four of these will be investigated in further detail: grd20, grd21, grd22 and grd23. ..
  47. ALPHA1-ADRENERGIC SIGNALING PATHWAYS IN HEART
    JANET ROBISHAW; Fiscal Year: 2002
    ..These studies are critical for the design of new therapeutic strategies aimed at enhancing or counteracting alpha/1-AR subtype specific effects in the heart. ..
  48. CELLULAR PHYSIOLOGY OF STAT3
    PRAVIN SEHGAL; Fiscal Year: 2002
    ..Establishing the basic subunit structure of the cytosolic 200-400 kDa and 1-2 MDa STAT3-containing complexes in IL-6-free and IL-6-treated cells is a sine qua non for further progress in this field. ..
  49. Physical properties of interfacial and structured water
    Gerald Pollack; Fiscal Year: 2005
    ..These are pilot studies designed to obtain preliminary data that may be useful for subsequent, more detailed investigations on the molecular basis of homeopathic procedures. ..
  50. HEREDITARY DEFECTS IN HUMAN CHLORIDE CHANNELS
    ALFRED GEORGE; Fiscal Year: 2001
    ..In addition, the applicant proposes to delineate the transmembrane topology of the CIC channel using a glycosylation tagging method that has previously been employed to generate a topological model of AMPA-type glutamate receptors. ..
  51. Colon Barrier Breakdown in the Elderly
    James Mullin; Fiscal Year: 2005
    ..Changes in membrane composition/fluidity are known to affect paracellular permeability in general, and tight junction proteins specifically. ..
  52. FASEB Conference on Calcium and Cell Function
    Richard Lewis; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  53. Autophagy: A Novel Antiviral Host Defense Pathway
    Beth Levine; Fiscal Year: 2007
    ..Together, these studies will provide novel insights about the role of autophagy in antiviral host defense and the role of viral evasion of autophagy in neurovirulence. ..
  54. SYNAPTIC REGULATION OF NITRIC OXIDE
    David Bredt; Fiscal Year: 2005
    ..On the other hand, an extended "P-finger" of the NNOS PDZ domain binds to PSD-95 and PSD-93, postsynaptic density proteins that mediate synaptic clustering of NMDA receptors. ..
  55. PHENOTYPE AND FUNCTION OF SENESCENT KERATINOCYTES
    Brian Nickoloff; Fiscal Year: 2005
    ....
  56. The Role of Novel Peroxins in Peroxisomal Biogenesis
    John Aitchison; Fiscal Year: 2007
    ..Preliminary results applying these techniques demonstrate that the first these proteins is a previously unknown peroxin required for peroxisome size regulation and segregation during cell division. ..
  57. 2004 Intermediate Filaments Gordon Conference
    M Omary; Fiscal Year: 2004
    ..abstract_text> ..
  58. Anthrax toxin-host cell interactions
    FRANCOISE VAN DER GOOT; Fiscal Year: 2004
    ..abstract_text> ..
  59. Role of Prdx 1 in Natural Killer Cells and Tumorigenesis
    Carola Neumann; Fiscal Year: 2007
    ..abstract_text> ..
  60. Chloride cation co-transporters and hyperalgesic states
    THEODORE PRICE; Fiscal Year: 2007
    ..These hypotheses comprise an integrated series of studies that test hypotheses concerning Abeta-fiber driven pain leading to possible therapeutic strategies for the alleviation of inflammatory pain. ..
  61. MOLECULAR ANALYSIS OF ANCHORING PROTEINS
    John Scott; Fiscal Year: 2003
    ....
  62. HPLC DETECTION OF RADICAL INTERMEDIATES
    Detcho Stoyanovsky; Fiscal Year: 2002
    ..The method is expected to display several orders of magnitude higher sensitivity than then traditional ESR spin trapping technique and may be a new approach in assays of oxidative stress. ..
  63. LASER SCANNING CONFOCAL IMAGING SYSTEM
    Liza Pon; Fiscal Year: 2003
    ..I. As an integral component of our Optical Microscopy Facility, the instrument will be accessible to members of the user group and others throughout the University, promoting collaboration and exchange of ideas. ..
  64. Nuclease-Resistant Aptamers to Botox and Anthrax Toxins
    John Bruno; Fiscal Year: 2004
    ..Such reagents could also be used in environmental biosensors or diagnostic test kits for detection of BOTOX and anthrax toxins in body fluids or environmental samples. ..
  65. Nuclease-Resistant Aptamers for Anthrax Opsonization
    John Bruno; Fiscal Year: 2004
    ..Such shielded aptamers could even be used in inhalers to enhance alveolar macrophage phagocytosis. ..