cell communication

Summary

Summary: Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP.

Top Publications

  1. ncbi Membrane vesicles as conveyors of immune responses
    Clotilde Thery
    Institut National de la Santé et de la Recherche Médicale U932, Institut Curie, 26 Rue d Ulm, Paris, 75005, France
    Nat Rev Immunol 9:581-93. 2009
  2. ncbi Quorum sensing: cell-to-cell communication in bacteria
    Christopher M Waters
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Annu Rev Cell Dev Biol 21:319-46. 2005
  3. ncbi Exosomes/microvesicles as a mechanism of cell-to-cell communication
    Giovanni Camussi
    Department of Internal Medicine, Centre for Molecular Biotechnology and Centre for Research in Experimental Medicine, Torino, Italy
    Kidney Int 78:838-48. 2010
  4. ncbi Exosomes--vesicular carriers for intercellular communication
    Mikael Simons
    Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Curr Opin Cell Biol 21:575-81. 2009
  5. pmc Microvesicles: mediators of extracellular communication during cancer progression
    Vandhana Muralidharan-Chari
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 0369, USA
    J Cell Sci 123:1603-11. 2010
  6. ncbi Astrocytes, from brain glue to communication elements: the revolution continues
    Andrea Volterra
    Department of Cell Biology and Morphology, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
    Nat Rev Neurosci 6:626-40. 2005
  7. ncbi Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles
    Neta Regev-Rudzki
    Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Cell 153:1120-33. 2013
  8. pmc Contact inhibition of locomotion in vivo controls neural crest directional migration
    Carlos Carmona-Fontaine
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Nature 456:957-61. 2008
  9. ncbi Prions hijack tunnelling nanotubes for intercellular spread
    Karine Gousset
    Unité de Trafic Membranaire et Pathogénèse, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nat Cell Biol 11:328-36. 2009
  10. pmc Collective chemotaxis requires contact-dependent cell polarity
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Dev Cell 19:39-53. 2010

Research Grants

  1. "The 1st International Conference on Osteoimmunology: Interactions of the Immune
    Joseph Lorenzo; Fiscal Year: 2006
  2. Vascular Cell Regulation of Connexins
    Brant Isakson; Fiscal Year: 2005
  3. Chemokine Receptor Chimeras by Synthetic Gene Library
    Michael Dustin; Fiscal Year: 2007
  4. Inverted two photon laser scanning microscope for host defense
    Michael Dustin; Fiscal Year: 2008
  5. Immunoreceptors
    Michael Dustin; Fiscal Year: 2008
  6. Epigenetic toxicity of polycyclic aromatic hydrocarbons
    Brad Upham; Fiscal Year: 2008
  7. Glial Biology Gordon Research Conference
    Vladimir Parpura; Fiscal Year: 2007
  8. Calcium-dependent glutamate release from astrocytes
    Vladimir Parpura; Fiscal Year: 2008
  9. BIOMEDICAL POLYMERS--CELL ADHESION AND CYTOKINES
    James Anderson; Fiscal Year: 2006
  10. Hematopoietic Circadian Rhythms
    Peter Quesenberry; Fiscal Year: 2005

Detail Information

Publications318 found, 100 shown here

  1. ncbi Membrane vesicles as conveyors of immune responses
    Clotilde Thery
    Institut National de la Santé et de la Recherche Médicale U932, Institut Curie, 26 Rue d Ulm, Paris, 75005, France
    Nat Rev Immunol 9:581-93. 2009
    ..This Review focuses on the role of membrane vesicles, in particular exosomes, in the communication between immune cells, and between tumour and immune cells...
  2. ncbi Quorum sensing: cell-to-cell communication in bacteria
    Christopher M Waters
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Annu Rev Cell Dev Biol 21:319-46. 2005
    ..how chemical information is integrated, processed, and transduced to control gene expression; how intra- and interspecies cell-cell communication is accomplished; and the intriguing possibility of prokaryote-eukaryote cross-communication.
  3. ncbi Exosomes/microvesicles as a mechanism of cell-to-cell communication
    Giovanni Camussi
    Department of Internal Medicine, Centre for Molecular Biotechnology and Centre for Research in Experimental Medicine, Torino, Italy
    Kidney Int 78:838-48. 2010
    ..An increasing body of evidence indicates that they play a pivotal role in cell-to-cell communication. Indeed, they may directly stimulate target cells by receptor-mediated interactions or may transfer from the ..
  4. ncbi Exosomes--vesicular carriers for intercellular communication
    Mikael Simons
    Max Planck Institute for Experimental Medicine, Gottingen, Germany
    Curr Opin Cell Biol 21:575-81. 2009
    ..Only recently light have been shed on the subcellular compartments and mechanisms involved in their biogenesis and secretion opening new avenues to understand their functions...
  5. pmc Microvesicles: mediators of extracellular communication during cancer progression
    Vandhana Muralidharan-Chari
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 0369, USA
    J Cell Sci 123:1603-11. 2010
    ..This Commentary summarizes recent literature on the properties and biogenesis of microvesicles and their potential role in cancer progression...
  6. ncbi Astrocytes, from brain glue to communication elements: the revolution continues
    Andrea Volterra
    Department of Cell Biology and Morphology, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
    Nat Rev Neurosci 6:626-40. 2005
    ..Examples of their specific and essential roles in normal physiological processes have begun to accumulate, and the number of diseases known to involve defective astrocytes is increasing...
  7. ncbi Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles
    Neta Regev-Rudzki
    Division of Infection and Immunity, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3052, Australia
    Cell 153:1120-33. 2013
    Cell-cell communication is an important mechanism for information exchange promoting cell survival for the control of features such as population density and differentiation...
  8. pmc Contact inhibition of locomotion in vivo controls neural crest directional migration
    Carlos Carmona-Fontaine
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Nature 456:957-61. 2008
    ..These results provide the first example of contact inhibition of locomotion in vivo, provide an explanation for coherent directional migration of groups of cells and establish a previously unknown role for non-canonical Wnt signalling...
  9. ncbi Prions hijack tunnelling nanotubes for intercellular spread
    Karine Gousset
    Unité de Trafic Membranaire et Pathogénèse, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nat Cell Biol 11:328-36. 2009
    ..been identified between cells, both in vitro and in vivo, and may represent a conserved means of cell-to-cell communication. Here we show that TNTs allow transfer of exogenous and endogenous PrP(Sc) between infected and naive ..
  10. pmc Collective chemotaxis requires contact-dependent cell polarity
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Dev Cell 19:39-53. 2010
    ....
  11. ncbi Exosomes: a common pathway for a specialized function
    Guillaume van Niel
    Institut Curie, CNRS UMR144, 75248 Paris Cedex, France
    J Biochem 140:13-21. 2006
    ..These findings open up new therapeutic and diagnostic strategies...
  12. pmc Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells
    K English
    Institute of Immunology, National University of Ireland Maynooth, Maynooth, Co Kildare, Ireland
    Clin Exp Immunol 156:149-60. 2009
    ..Overall, this study provides a rational basis for ongoing clinical studies involving allogeneic MSC...
  13. ncbi Exosomal-like vesicles are present in human blood plasma
    Marie Pierre Caby
    Institut National de la Sante et de la Recherche Medicale, Unité 520, Institut Curie, 12 rue Lhomond, 75005 Paris, France
    Int Immunol 17:879-87. 2005
    ..Our results demonstrate that blood is a physiological fluid for exosome circulation in the body, suggesting their role in cell-cell or organ-organ communications as carriers for molecules that need to reach distant cell targets...
  14. ncbi Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication
    J Ratajczak
    The Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 20:1487-95. 2006
    ....
  15. ncbi Network biology: understanding the cell's functional organization
    Albert Laszlo Barabasi
    Department of Physics, University of Notre Dame, Notre Dame, Indiana 46556, USA
    Nat Rev Genet 5:101-13. 2004
  16. ncbi The transcellular spread of cytosolic amyloids, prions, and prionoids
    Adriano Aguzzi
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Neuron 64:783-90. 2009
    ....
  17. ncbi The immunological synapse of CTL contains a secretory domain and membrane bridges
    J C Stinchcombe
    Sir William Dunn School of Pathology, South Parks Road, Oxford, OX1 3RE, United Kingdom
    Immunity 15:751-61. 2001
    ..Electron microscopy reveals continuities forming membrane bridges between the CTL and target cell membranes, suggesting a possible mechanism for this transfer...
  18. ncbi Exosomes: new players in cell-cell communication
    Claudia Bang
    Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany
    Int J Biochem Cell Biol 44:2060-4. 2012
    ..discovery that exosomes contain proteins, messenger and microRNAs suggests a role as mediators in cell-to-cell communication. Exosomes can be transported between different cells and influence physiological pathways in the recipient ..
  19. ncbi Rab27a and Rab27b control different steps of the exosome secretion pathway
    Matias Ostrowski
    INSERM U932, 26 Rue d Ulm, 75005 Paris, France
    Nat Cell Biol 12:19-30; sup pp 1-13. 2010
    ..Our results therefore strengthen the link between MVEs and exosomes, and introduce ways of manipulating exosome secretion in vivo...
  20. ncbi Keratinocyte-fibroblast interactions in wound healing
    Sabine Werner
    Institute of Cell Biology, Eidgenossische Technische Hochschule Zurich, Honggerberg, Zurich, Switzerland
    J Invest Dermatol 127:998-1008. 2007
    ..As the phenotype of fibroblasts from different tissues or body sites becomes better defined, we may understand their individual contribution in wound healing in more detail and possibly explain different clinical outcomes...
  21. ncbi Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing
    C Fuqua
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Annu Rev Genet 35:439-68. 2001
    ..Recent studies have begun to integrate acyl-HSL quorum sensing into global regulatory networks and establish its role in developing and maintaining the structure of bacterial communities...
  22. ncbi Molecular mechanisms regulating hair follicle development
    Sarah E Millar
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 118:216-25. 2002
    ..The purpose of this review is to summarize recent progress in our understanding of the molecular mechanisms regulating hair follicle formation, and to discuss ways in which this information may eventually be utilized in the clinic...
  23. ncbi Gap junctions and the connexin protein family
    Goran Sohl
    Institut fur Genetik, Abteilung Molekulargenetik, Universitat Bonn, 53117 Bonn, Germany
    Cardiovasc Res 62:228-32. 2004
    ..As yet only little is known about mutations in the human genes for Cx37, Cx40, Cx43 and Cx45. Thus, a profound comparison between human and mouse phenotypes is not yet possible...
  24. pmc Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta
    K Nakamura
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 194:629-44. 2001
    ..This, plus the fact that we could find no evidence that a soluble factor mediates suppression, strongly suggests that CD4(+)CD25(+) T cells exert immunosuppression by a cell-cell interaction involving cell surface TGF-beta1...
  25. pmc Transfer of microRNAs by embryonic stem cell microvesicles
    Alex Yuan
    Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, California, United States of America
    PLoS ONE 4:e4722. 2009
    ..Embryonic stem cell microvesicles may be useful therapeutic tools for transferring mRNA, microRNAs, protein, and siRNA to cells and may be important mediators of signaling within stem cell niches...
  26. ncbi Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo
    Amelia Bartholomew
    University of Illinois, Chicago 60607, USA
    Exp Hematol 30:42-8. 2002
    ..We hypothesized that the activities of MSCs in the bone marrow microenvironment might also include immunomodulatory effects on lymphocytes...
  27. ncbi Functional connectivity between immune cells mediated by tunneling nanotubules
    Simon C Watkins
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Immunity 23:309-18. 2005
    ..These results demonstrate that nonneuronal cells can transmit signals to distant cells through a physically connected network...
  28. ncbi New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes
    Helen Sheldon
    Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    Blood 116:2385-94. 2010
    ..This reversal in phenotype appears to enhance vessel formation and is a new form of signaling for Notch ligands that expands their signaling potential beyond cell-cell contact...
  29. pmc Intercellular (mis)communication in neurodegenerative disease
    Gwenn A Garden
    Department of Neurology, University of Washington, Seattle, WA 98195, USA
    Neuron 73:886-901. 2012
    ..Here, we review findings highlighting the importance of pathological cell-cell communication in neurodegenerative disease...
  30. ncbi Myeloid microvesicles are a marker and therapeutic target for neuroinflammation
    Claudia Verderio
    Italian National Research Council Institute of Neuroscience and Department of Medical Pharmacology, University of Milan, Milan, Italy
    Ann Neurol 72:610-24. 2012
    ..The aim of the study was to evaluate whether MVs are released by microglia/macrophages in vivo and whether their number varies in brain inflammatory conditions, such as multiple sclerosis (MS)...
  31. ncbi Small talk. Cell-to-cell communication in bacteria
    Bonnie L Bassler
    Department of Molecular Biology, Princeton University, NJ 08544, USA
    Cell 109:421-4. 2002
    ..A diverse array of secreted chemical signal molecules and signal detection apparatuses facilitate highly productive intra- and interspecies relationships...
  32. ncbi Local Ca2+ detection and modulation of synaptic release by astrocytes
    Maria Amalia Di Castro
    Department of Cell Biology and Morphology, University of Lausanne, Lausanne, Switzerland
    Nat Neurosci 14:1276-84. 2011
    ..These data provide direct evidence that astrocytes are integrated in local synaptic functioning in adult brain...
  33. pmc The effects of connexin phosphorylation on gap junctional communication
    Paul D Lampe
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North DE 320, Box 19024, Seattle, WA 98109, USA
    Int J Biochem Cell Biol 36:1171-86. 2004
    ..In several cases, use of site-directed mutants of these sites have shown that these specific phosphorylation events can be linked to changes in gap junctional communication...
  34. ncbi Tube morphogenesis: making and shaping biological tubes
    Barry Lubarsky
    Howard Hughes Medical Institute, Department of Biochemistry, Stanford University, School of Medicine, Stanford, CA 94305, USA
    Cell 112:19-28. 2003
    ..We propose a unifying mechanism of tube morphogenesis that has been modified to create tube diversity and describe how defects in the tube size-sensing step can lead to polycystic kidney disease...
  35. pmc Radiation-induced bystander signalling in cancer therapy
    Kevin M Prise
    Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast, UK
    Nat Rev Cancer 9:351-60. 2009
    ..This Review outlines the key aspects of radiation-induced intercellular signalling and assesses its relevance for existing and future radiation-based therapies...
  36. ncbi Cysteine-rich peptides (CRPs) mediate diverse aspects of cell-cell communication in plant reproduction and development
    Eleanor Marshall
    School of Life Sciences, University of Warwick, Wellesbourne Campus, Wellesbourne, UK
    J Exp Bot 62:1677-86. 2011
    Cell-cell communication in plants is essential for the correct co-ordination of reproduction, growth, and development...
  37. pmc Functional microRNA is transferred between glioma cells
    Mark Katakowski
    Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Cancer Res 70:8259-63. 2010
    ..These findings reveal a novel mechanism of targeted intercellular protein regulation between brain tumor cells...
  38. ncbi The brain tumor microenvironment
    Nikki A Charles
    Departments of Surgery Neurosurgery, Neurology, and Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, USA
    Glia 59:1169-80. 2011
    ..cell populations and highlight the pathological impact and signaling pathways known for these types of cell-cell communication. The tumor-vasculature not only nourishes glioblastomas, but also provides a specialized niche for these ..
  39. pmc Intercellular communication by exchange of cytoplasmic material via tunneling nano-tube like structures in primary human renal epithelial cells
    Sophie Domhan
    Department of Medicine, Center of Cancer Systems Biology, St Elizabeth s Medical Center, Tufts University, Boston, Massachusetts, United States of America
    PLoS ONE 6:e21283. 2011
    ..Our data indicates an unexpected dynamic of intercellular communication between RPTEC by exchange of cytosolic material, which may play an important role in renal physiology...
  40. pmc Pyramidal cell communication within local networks in layer 2/3 of rat neocortex
    Carl Holmgren
    Karolinska Institute, Department of Neuroscience, Retzius vag 8, B2 2, S 17177 Stockholm, Sweden
    J Physiol 551:139-53. 2003
    ..We suggest that computation in the local network may proceed not only by direct pyramidal-pyramidal cell communication but also via local interneurons...
  41. pmc New insights into neuron-glia communication
    R Douglas Fields
    Neurocytology and Physiology Section, National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Science 298:556-62. 2002
    ..By releasing neurotransmitters and other extracellular signaling molecules, glia can affect neuronal excitability and synaptic transmission and perhaps coordinate activity across networks of neurons...
  42. ncbi The cadherin superfamily in neuronal connections and interactions
    Masatoshi Takeichi
    RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Nat Rev Neurosci 8:11-20. 2007
    ..In this review I discuss the roles of three subfamilies - classic cadherins, Flamingo/CELSRs and protocadherins - in the regulation of neuronal recognition and connectivity...
  43. ncbi Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype
    Soufiane Ghannam
    Institut National de la Sante et de la Recherche Medicale, Unité 844, Hopital St Eloi, Universite Montpellier I, France
    J Immunol 185:302-12. 2010
    ..These results showed that, under inflammatory conditions, MSCs mediate the adhesion of Th17 cells via CCR6 and exert anti-inflammatory effects through the induction of a T cell regulatory phenotype in these cells...
  44. pmc Reciprocal activating interaction between natural killer cells and dendritic cells
    Franca Gerosa
    Department of Pathology, Section of Immunology, University of Verona, 37100 Verona, Italy
    J Exp Med 195:327-33. 2002
    ..These data demonstrated for the first time a bidirectional cross talk between NK cells and DC, in which NK cells activated by IL-2 or by mature DC induce DC maturation...
  45. ncbi Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    Hadi Valadi
    Department of Internal Medicine, The Sahlgrenska Academy, Goteborg University, Sweden
    Nat Cell Biol 9:654-9. 2007
    ..In summary, we show that exosomes contain both mRNA and microRNA, which can be delivered to another cell, and can be functional in this new location. We propose that this RNA is called "exosomal shuttle RNA" (esRNA)...
  46. pmc Stromal effects on mammary gland development and breast cancer
    Bryony S Wiseman
    Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Science 296:1046-9. 2002
    ..To find cures for diseases like breast cancer that rely on epithelial-stromal crosstalk, we must understand how these different cell types communicate with each other...
  47. pmc Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription
    Jason M Aliotta
    Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Division of Hematology and Oncology, Providence, RI 02903, USA
    Exp Hematol 38:233-45. 2010
    ..The present studies establish that entry of lung-derived microvesicles into marrow cells is a prerequisite for marrow expression of pulmonary epithelial cell-derived mRNA...
  48. ncbi Friends or foes - bipolar effects of the tumour stroma in cancer
    Margareta M Mueller
    Group Tumor and Microenvironment, German Cancer Research Centre, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nat Rev Cancer 4:839-49. 2004
    ..What have we recently learned from studying tumour-stroma interactions, and will this help to define new targets for therapy?..
  49. ncbi Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery
    J Ratajczak
    Stem Cell Biology Program, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 20:847-56. 2006
    ..We postulate that ES-MV may efficiently expand HPC by stimulating them with ES-MV expressed ligands (e.g., Wnt-3) as well as increase their pluripotency after horizontal transfer of ES-derived mRNA...
  50. ncbi Gap junctions and connexin-interacting proteins
    Ben N G Giepmans
    Department of Neurosciences, The National Center of Microscopy and Imaging Research, University of California San Diego, School of Medicine, 1000 BSB, 9500 Gilman Drive, MC0608, La Jolla, CA 92093 0608, USA
    Cardiovasc Res 62:233-45. 2004
    ..The striking similarity of proteins present at the cytoplasmic face of tight junctions, adherens junctions and gap junctions and their possible role in gene transcription and cytoskeletal anchorage is highlighted...
  51. ncbi Expression of Pseudomonas aeruginosa virulence genes requires cell-to-cell communication
    L Passador
    Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, NY 14620
    Science 260:1127-30. 1993
    ..PAI provides P. aeruginosa with a means of cell-to-cell communication that is required for the expression of virulence genes and may provide a target for therapeutic approaches.
  52. pmc Molecular regulation of lumen morphogenesis
    Anirban Datta
    Department of Anatomy, University of California San Francisco, CA 94143 2140, USA
    Curr Biol 21:R126-36. 2011
    ..We here discuss progress in understanding common design principles underpinning de novo lumen formation and expansion...
  53. pmc EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt
    Kentaro Abe
    RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 105:13-9. 2008
    ....
  54. pmc Tunnelling nanotubes: a highway for prion spreading?
    Karine Gousset
    Institut Pasteur, Unité de Trafic Membranaire et Pathogénèse, Paris, France
    Prion 3:94-8. 2009
    ..Therefore, we propose a role for TNTs during prion spreading from the periphery to the central nervous system (CNS). Here, we discuss some of the key steps where TNTs might play a role during prion neuroinvasion...
  55. pmc Tunneling-nanotube development in astrocytes depends on p53 activation
    Y Wang
    Laboratory of Neurobiology and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing, China
    Cell Death Differ 18:732-42. 2011
    ..Akt, phosphoinositide 3-kinase and mTOR are involved in TNT induction. Our data suggest that TNTs might be a mechanism for cells to respond to harmful signals and transfer cellular substances or energy to another cell under stress...
  56. ncbi Tumor-stroma interactions in pancreatic ductal adenocarcinoma
    Daruka Mahadevan
    Hematology Oncology, The University of Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 58724, USA
    Mol Cancer Ther 6:1186-97. 2007
    ..This review summarizes our current understanding of the mechanisms that potentially drive the DR in PDA and future possibilities for therapeutic targeting of this critical process...
  57. pmc Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes
    Tomoya Katakai
    Center for Molecular Biology and Genetics, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    J Exp Med 200:783-95. 2004
    ..These findings suggest that signals from lymphocytes induce FRCs to form the network that supports the movement and interactions of immune effectors within the lymph node...
  58. ncbi Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism
    David C Gondek
    Department of Microbiology and Immunology, Dartmouth Medical School and Norris Cotton Cancer Center, Lebanon, NH 03756, USA
    J Immunol 174:1783-6. 2005
    ..In summary, GZ-B is one of the key mechanisms through which CD4+CD25+ Treg induce cell contact-mediated suppression...
  59. pmc Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders
    Anja Schneider
    Department of Psychiatry and Psychotherapy, University Medicine Goettingen, Von Siebold Str 5, 37075, Goettingen, Germany
    Cell Tissue Res 352:33-47. 2013
    ..In this review, we focus on the cell biology and function of neuronal microvesicles/exosomes and discuss the evidence for pathogenic intercellular protein transfer mediated by vesicular carriers...
  60. ncbi Mycobacterium tuberculosis-induced neutrophil ectosomes decrease macrophage activation
    Tonya Azevedo Duarte
    Health Science Institute, Federal University of Bahia, Salvador, BA, Brazil
    Tuberculosis (Edinb) 92:218-25. 2012
    ..We found that the ectosomes derived from infected neutrophils are biologically active and can influence the survival of Mycobacterium tuberculosis within macrophages...
  61. pmc Rab11 regulates cell-cell communication during collective cell movements
    Damien Ramel
    Institute for Research in Immunology and Cancer IRIC and Department of Pathology and Cell Biology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, H3C 3J7, Canada
    Nat Cell Biol 15:317-24. 2013
    ..group to ensure that Rac activity is properly restricted to the leading cell through regulation of cell-cell communication. In addition, we show that Rab11 binds to the actin cytoskeleton regulator Moesin and regulates its ..
  62. ncbi The Hippo pathway and apico-basal cell polarity
    Alice Genevet
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3LY, UK
    Biochem J 436:213-24. 2011
    ..We focus on the regulation of Yki/YAP by apical proteins, but also on how the Hpo pathway might in turn influence apical domain size as part of a regulatory feedback loop...
  63. ncbi Natural killer cells and dendritic cells: rendezvous in abused tissues
    Alessandro Moretta
    Dipartimento di Medicina Sperimentale, Sezione di Istologia, and Centro di Eccellenza per le Ricerche Biomediche, Universita degli Studi di Genova, 16132 Genova, Italy
    Nat Rev Immunol 2:957-64. 2002
    ....
  64. ncbi Exosomes: immune properties and potential clinical implementations
    Nathalie Chaput
    Institut National de la Santé et de la Recherche Médicale U1015, Villejuif, 94805, France
    Semin Immunopathol 33:419-40. 2011
    ....
  65. ncbi Mechanisms of axon ensheathment and myelin growth
    Diane L Sherman
    Centre for Neuroscience Research, University of Edinburgh, Summerhall, Edinburgh EH9 1QH, UK
    Nat Rev Neurosci 6:683-90. 2005
    ....
  66. ncbi TGFβ modulates cell-to-cell communication in early epithelial-to-mesenchymal transition
    C E Hills
    School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
    Diabetologia 55:812-24. 2012
    ..Here we investigated whether TGF-β1-induced epithelial-to-mesenchymal transition (EMT) plays a role in alterations in cell adhesion, cell coupling and cell communication in the human renal proximal tubule.
  67. ncbi Glioblastoma-induced attraction of endogenous neural precursor cells is associated with improved survival
    Rainer Glass
    Cellular Neuroscience Group, Max Delbruck Center for Molecular Medicine, 13092 Berlin, Germany
    J Neurosci 25:2637-46. 2005
    ..Our results indicate that tumor cells attract endogenous precursor cells; the presence of precursor cells is antitumorigenic; and this cellular interaction decreases with aging...
  68. ncbi A bacterial cell-cell communication signal with cross-kingdom structural analogues
    Lian Hui Wang
    Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
    Mol Microbiol 51:903-12. 2004
    Extracellular signals are the key components of microbial cell-cell communication systems. This report identified a diffusible signal factor (DSF), which regulates virulence in Xanthomonas campestris pv...
  69. ncbi Macrophage- and dendritic cell--dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF
    Andrew Craxton
    Department of Microbiology, University of Washington, Seattle, WA 98195, USA
    Blood 101:4464-71. 2003
    ....
  70. ncbi Reprogramming metastatic tumour cells with embryonic microenvironments
    Mary J C Hendrix
    Cancer Biology and Epigenomics Program, Children s Memorial Research Centre, Robert H Lurie Comprehensive Cancer Centre, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA
    Nat Rev Cancer 7:246-55. 2007
    ..This Review will summarize the embryonic models used to reverse the metastatic melanoma phenotype, and highlight the prominent signalling pathways that have emerged as noteworthy targets for future consideration...
  71. pmc Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss
    Michael M Halassa
    Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 61:213-9. 2009
    ....
  72. ncbi EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets
    Irena Konstantinova
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Cell 129:359-70. 2007
    ..We further show that EphA-ephrin-A-mediated beta cell communication is bidirectional: EphA forward signaling inhibits insulin secretion, whereas ephrin-A reverse signaling ..
  73. ncbi Interaction of human mesenchymal stem cells with cells involved in alloantigen-specific immune response favors the differentiation of CD4+ T-cell subsets expressing a regulatory/suppressive phenotype
    Rita Maccario
    Laboratorio di Immunologia dei Trapianti, Oncoematologia Pediatrica, IRCCS Policlinico San Matteo, P le Golgi 19, 27100 Pavia, Italy
    Haematologica 90:516-25. 2005
    ..We extended the evaluation of mechanisms responsible for the immune regulatory effect derived from the interaction of human MSC with cells involved in alloantigen-specific immune response in mixed lymphocyte culture (MLC)...
  74. ncbi Nanotubular highways for intercellular organelle transport
    Amin Rustom
    Interdisciplinary Center of Neuroscience IZN, Institute of Neurobiology, University of Heidelberg, INF 364, Heidelberg 69120, Germany
    Science 303:1007-10. 2004
    Cell-to-cell communication is a crucial prerequisite for the development and maintenance of multicellular organisms...
  75. ncbi Intercellular communication in the mammalian ovary: oocytes carry the conversation
    Martin M Matzuk
    Department of Pathology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    Science 296:2178-80. 2002
    ..The challenge for the future is to identify the factors that participate in this communication and their mechanisms of action...
  76. ncbi Socializing with the neighbors: stem cells and their niche
    Elaine Fuchs
    Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Cell 116:769-78. 2004
    ..In this review, we examine adult stem cell niches and their impact on stem cell biology...
  77. ncbi Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses
    T B Geijtenbeek
    Department of Tumor Immunology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Cell 100:575-85. 2000
    ..Since antibodies against DC-SIGN inhibit DC-induced proliferation of resting T cells, our findings predict that DC-SIGN enables T cell receptor engagement by stabilization of the DC-T cell contact zone...
  78. pmc Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses
    João Pedro Pereira
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, 94143, USA
    Int Immunol 22:413-9. 2010
    ..In this review, we discuss current understanding of the roles played by chemokines, S1P and EBI2 in the migration events that underlie humoral immune responses...
  79. ncbi Cell-cell communication in carcinogenesis
    J E Trosko
    Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan 48824, USA
    Front Biosci 3:d208-36. 1998
    ..Normal homeostatic control of these three forms of cell communication determines whether: (a) the cell remains quiescent (Go); (b) enters into the cell proliferation phase; (c) ..
  80. ncbi Tunneling nanotubes: a new route for the exchange of components between animal cells
    Hans Hermann Gerdes
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, Bergen 5009, Norway
    FEBS Lett 581:2194-201. 2007
    ..It has been proposed that TNTs represent a novel and general biological principle of cell-to-cell communication and it becomes increasingly apparent that they fulfill important functions in the physiological processes of ..
  81. pmc Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels
    Xiang Wang
    Department of Biomedicine, University of Bergen, 5009 Bergen, Norway
    Proc Natl Acad Sci U S A 107:17194-9. 2010
    Tunneling nanotubes (TNTs) are recently discovered conduits for a previously unrecognized form of cell-to-cell communication. These nanoscale, F-actin-containing membrane tubes connect cells over long distances and facilitate the ..
  82. ncbi The microenvironment of the tumour-host interface
    L A Liotta
    Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Nature 411:375-9. 2001
    ..A new class of cancer therapies that targets this pathological communication interface between tumour cells and host cells is currently under development...
  83. pmc Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia
    X Zhang
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Proc Natl Acad Sci U S A 104:9864-9. 2007
    ..the nucleus, is mainly responsible for synthesis of macromolecules and has a limited role in cell-to-cell communication. Using sniffer patch recordings, we show here that electrical stimulation of dorsal root ganglion (DRG) ..
  84. pmc SAP-controlled T-B cell interactions underlie germinal centre formation
    Hai Qi
    Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 455:764-9. 2008
    ..These results offer an explanation for the germinal centre defect due to SAP deficiency and provide new insights into the bi-directional communication between cognate T and B cells in vivo...
  85. ncbi Dendritic cells interact directly with naive B lymphocytes to transfer antigen and initiate class switching in a primary T-dependent response
    M Wykes
    Sir William Dunn School of Pathology, University of Oxford, United Kingdom
    J Immunol 161:1313-9. 1998
    ..Taken together, these observations show that DC have an important role in the initiation of Ab synthesis by direct interaction with B cells...
  86. ncbi Structure and mechanism of cadherins and catenins in cell-cell contacts
    Sabine Pokutta
    Department of Structural Biology and Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Annu Rev Cell Dev Biol 23:237-61. 2007
    ....
  87. ncbi Osteoclast-osteoblast communication
    Koichi Matsuo
    Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, 160 8582 Tokyo, Japan
    Arch Biochem Biophys 473:201-9. 2008
    ..At the termination phase, bone remodeling is completed by osteoblastic bone formation and mineralization of bone matrix. Here, we describe molecular communication between osteoclasts and osteoblasts at distinct phases of bone remodeling...
  88. pmc Different types of cell-to-cell connections mediated by nanotubular structures
    Peter Veranic
    Institute of Cell Biology, Faculty of Medicine, University of Ljubljana, SI 1000 Ljubljana, Slovenia
    Biophys J 95:4416-25. 2008
    ..A possible model of formation and mechanical stability of nanotubes that bridge two neighboring cells is discussed...
  89. ncbi Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cells
    Emi Nagoshi
    Department of Molecular Biology and NCCR Frontiers in Genetics, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    Cell 119:693-705. 2004
    ..Specifically, the circadian oscillator gates cytokinesis to defined time windows, and mitosis elicits phase shifts in circadian cycles...
  90. ncbi Activated T cells recruit exosomes secreted by dendritic cells via LFA-1
    Esther N M Nolte-'t Hoen
    Faculty of Veterinary Medicine, Department of Biochemistry and Cell Biology, Utrecht University, Utrecht, The Netherlands
    Blood 113:1977-81. 2009
    ..These results imply that DC exosomes secreted in the extracellular milieu during cognate T-cell-DC interactions are targeted to T cells activated in that microenvironment...
  91. pmc Hijacking the T-cell communication network by the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) p12 and p8 proteins
    Nancy Van Prooyen
    Animal Models and Retroviral Vaccine Section, Vaccine Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892 5065, USA
    Mol Aspects Med 31:333-43. 2010
    ..Altogether the current knowledge demonstrates that the concerted activity of p8 and p12 is essential for the persistence of virus infected cells in the host...
  92. ncbi Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6
    Gaetan Jego
    Baylor Institute for Immunology Research, 3434 Live Oak Street, Dallas, Texas 75204, USA
    Immunity 19:225-34. 2003
    ..These plasma cells display the high levels of CD38 found on tissue plasma cells. Thus, pDCs are critical for the generation of plasma cells and antibody responses...
  93. pmc Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33
    Tatjana Pecaric-Petkovic
    Institute of Immunology, University Hospital Bern, Inselspital, Bern, Switzerland
    Blood 113:1526-34. 2009
    ....
  94. ncbi CD8+ dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivo
    Elodie Segura
    Centre de Recherche, Institut Curie, Paris, France
    J Immunol 179:1489-96. 2007
    ..We propose a new role for LFA-1 on DCs, as a receptor for exosomes to favor Ag transfer between DCs in vivo...
  95. ncbi Membrane nanotubes: dynamic long-distance connections between animal cells
    Daniel M Davis
    Division of Cell and Molecular Biology, Sir Alexander Fleming Building, Imperial College, London, SW7 2AZ, UK
    Nat Rev Mol Cell Biol 9:431-6. 2008
    ..Despite recent progress in this young research field, further research is sorely needed...
  96. ncbi Gap junctions and the propagation of cell survival and cell death signals
    D V Krysko
    Department of Human Anatomy, Embryology, Histology and Medical Physics, Ghent University, 9000 Ghent, Belgium
    Apoptosis 10:459-69. 2005
    ..Finally, direct signal transduction activity of connexins in cell death and survival pathways is addressed...
  97. ncbi Connexins and their channels in cell growth and cell death
    Mathieu Vinken
    Department of Toxicology, Vrije Universiteit Brussel VUB, Laarbeeklaan 103, B 1090 Brussels, Belgium
    Cell Signal 18:592-600. 2006
    ..We also briefly discuss the role of gap junctional intercellular communication in carcinogenesis and the potential use of connexins as tools for cancer therapy...
  98. pmc The art of cellular communication: tunneling nanotubes bridge the divide
    Steffen Gurke
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway
    Histochem Cell Biol 129:539-50. 2008
    ..Recently, a new type of cell-to-cell communication was discovered, based on de novo formation of membranous nanotubes between cells...
  99. ncbi Upregulation of the viability of nucleus pulposus cells by bone marrow-derived stromal cells: significance of direct cell-to-cell contact in coculture system
    Yukihiro Yamamoto
    Department of Orthopaedic Surgery, Tokai University School of Medicine, Kanagawa, Japan
    Spine (Phila Pa 1976) 29:1508-14. 2004
    ..Upregulation of the viability of nucleus pulposus cells by coculture with bone marrow-derived stromal cells using a novel culture system...
  100. ncbi N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells
    G Li
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 61:3819-25. 2001
    ....
  101. ncbi Intercellular transfer mediated by tunneling nanotubes
    Hans Hermann Gerdes
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, Bergen 5009, Norway
    Curr Opin Cell Biol 20:470-5. 2008
    ..In 2004, a new route of cell-to-cell communication mediated by tunneling nanotubes (TNT) was reported...

Research Grants81

  1. "The 1st International Conference on Osteoimmunology: Interactions of the Immune
    Joseph Lorenzo; Fiscal Year: 2006
    ..The conference will be held on May 26, 2006 to June 2, 2006 in Crete, Greece. [unreadable] [unreadable] [unreadable] [unreadable]..
  2. Vascular Cell Regulation of Connexins
    Brant Isakson; Fiscal Year: 2005
    Cell-cell communication between endothelial cells (EC) and smooth muscle cells (SMC), provided by gap junctions, coordinates vessel contractility and electrical conduction...
  3. Chemokine Receptor Chimeras by Synthetic Gene Library
    Michael Dustin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. Inverted two photon laser scanning microscope for host defense
    Michael Dustin; Fiscal Year: 2008
    ..The impact on public health will be to develop better strategies to fight infections and reduce the incidence of pathogen triggered autoimmunity. [unreadable] [unreadable] [unreadable]..
  5. Immunoreceptors
    Michael Dustin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  6. Epigenetic toxicity of polycyclic aromatic hydrocarbons
    Brad Upham; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  7. Glial Biology Gordon Research Conference
    Vladimir Parpura; Fiscal Year: 2007
    ..issues at the frontier of glial biology involving neuron and glib interactions, with strong emphasis on cell-cell communication. Major conference themes include glial control of neuronal functions, neuronal control of glial activities, ..
  8. Calcium-dependent glutamate release from astrocytes
    Vladimir Parpura; Fiscal Year: 2008
    ..Since astrocytes modulate synaptic transmission by releasing glutamate, this new insight into glial action has potential to change the way we think about central nervous system functions and dysfunctions [unreadable] [unreadable]..
  9. BIOMEDICAL POLYMERS--CELL ADHESION AND CYTOKINES
    James Anderson; Fiscal Year: 2006
    ....
  10. Hematopoietic Circadian Rhythms
    Peter Quesenberry; Fiscal Year: 2005
    ..Transgenic Pert-luc rats and mice will be available at University of Virginia, and the array/informatic studies done at Princeton. ..
  11. LYMPHOCYTE/MACROPHAGE INTERACTIONS ON BIOMATERIALS
    James Anderson; Fiscal Year: 2001
    ..Results from our combined studies will lead to a greater appreciation of these complex cell/material interactions and novel design criteria for new biomaterials and tissue-engineered surfaces. ..
  12. INFECTION MECHANISMS WITH CARDIOVASCULAR PROSTHESES
    JAMES MORLEY ANDERSON; Fiscal Year: 2010
    ..A fibrinogen-based peptide sequence based on fibrinogen/Fbe (S. epidermidis) will be used as a blocking ligand to investigate adhesion blocking mechanisms to prevent bacterial aggregation and biofilm formation. ..
  13. REGULATION OF MYOCARDIAL GAP JUNCTIONS
    Jeffrey Saffitz; Fiscal Year: 2006
    ..abstract_text> ..
  14. Zebrafish in Comparative Context: A Symposium
    Thomas Schilling; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  15. Carbohydrate-carbohydrate interaction in basic cell biology
    Sen itiroh Hakomori; Fiscal Year: 2006
    ..abstract_text> ..
  16. T Cell Activation in Lupus Proteomic Characterization
    Joseph Craft; Fiscal Year: 2005
    ..abstract_text> ..
  17. Cell Interactions in Synapes Formation and Function
    Juan Bruses; Fiscal Year: 2005
    ....
  18. Cryopreservation of the model organism Drosophila melanogaster
    BRENT SINCLAIR; Fiscal Year: 2007
    ..The ultimate goal is to cryopreserve D. melanogaster, an achievement that will greatly increase the utility of the Drosophila model for human disease research. ..
  19. TGF BETA Regulation of Osteoclast Apoptosis
    MERRY OURSLER; Fiscal Year: 2007
    ..Understanding osteoclast apoptosis regulation may provide important avenues for therapies to slow bone degradation during pathological bone loss. ..
  20. p120-catenin sub-family functions
    Pierre D McCrea; Fiscal Year: 2010
    ....
  21. Molecular Mechanisms of Natural Killer Cell Activation
    Subramaniam Malarkannan; Fiscal Year: 2010
    ..Mechanisms identified here will not only have practical implications in tumor and graft immunity but will serve as models for other systems in which the responding cell must balance a number of activating and inhibitory inputs. ..
  22. Lymphocyte homeostastis & regulation during aging
    MICHAEL PAUL CANCRO; Fiscal Year: 2010
    ..abstract_text> ..
  23. Toll-like receptors and intestinal inflammation
    Charalabos Pothoulakis; Fiscal Year: 2010
    ..Our proposed studies will provide significant information relevant to the pathogenesis of colonic inflammation, including IBD. ..
  24. Angiogenic determinants of endogenous adult neurogenesis
    Steven Goldman; Fiscal Year: 2008
    ....
  25. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2009
    ..Collectively, the genetic program controlling T cell lineage commitment and maturation will be determined, allowing a better understanding of leukemogenesis. ..
  26. A novel method to discover genes that protect cells from alpha synuclein
    STEPHAN WITT; Fiscal Year: 2007
    ..This method allows us to screen libraries of genes- genes from any organism-to discover genes that protect against a-syn toxicity. [unreadable] [unreadable]..
  27. MSM-Multi-scale Analysis of Cellular Force Transmission and Biochemical Activatio
    Roger Kamm; Fiscal Year: 2007
    ..4. Conduct experiments in reconstituted actin networks to provide a pheonological basis for evaluation and evalidation of the computational models. ..
  28. Molecular Genetics of Midline Glial Development
    Stephen T Crews; Fiscal Year: 2010
    ..abstract_text> ..
  29. FILAMENTOUS INFLUENZA VIRUS AND MICROBIAL COLONIZATION
    Paul Roberts; Fiscal Year: 2004
    ..In parallel, we will also determine whether prior bacterial colonization can affect influenza virus replication in respiratory epithelium. ..
  30. Steroids and Stem Cell in Carcinogenesis
    Doris Benbrook; Fiscal Year: 2004
    ..This research will enhance our understanding of the process of carcinogenesis and chemoprevention, which could ultimately translate into strategies and pharmaceuticals for prevention of cancer. ..
  31. PATHOBIOLOGY OF THE OSTEOCLAST IN PAGETS DISEASE
    G Roodman; Fiscal Year: 2002
    ..abstract_text> ..
  32. B CELL DEFICIENCY IN A/WYSNJ MICE
    Michael Cancro; Fiscal Year: 2001
    ....
  33. GENETIC CONTRIBUTION TO THE STRESS RESPONSE
    Antonio De Maio; Fiscal Year: 2002
    ..The results from this analysis will provide us with candidate genes that contribute to the heterogeneity of the inflammatory response. ..
  34. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
    ....
  35. PLASMALOPSYCHOSINE AS NEUROTROPHIC FACTOR
    Senitiroh Hakomori; Fiscal Year: 2003
    ..Results of these studies may provide a basis for development of PLPS and its analogues as therapeutic reagents for neurodegenerative diseases and neuronal injury. ..
  36. Genetic Etiologies of Esophageal Barrett's and Cancer
    Charis Eng; Fiscal Year: 2003
    ..This might facilitate molecular diagnostics and early prediction as well as targeted surveillance and prophylaxis. ..
  37. Ligand Binding Kinetics and Cell Adhesion by Fc Receptor
    Cheng Zhu; Fiscal Year: 2005
    ..It may also provide guidance to the development of Fc-gamma-R- based drugs for treatment of inflammatory disorders and auto-immune diseases. ..
  38. CHEMISTRY AND BIOLOGY OF MALONDIALDEHYDE DNA ADDUCTS
    LAWRENCE MARNETT; Fiscal Year: 2004
    ..The results of these experiments will define the chemistry and biology of a family of structurally dynamic lesions in the genome derived from an endogenous metabolic product of lipid oxidation. ..
  39. Transcriptional & cell cycle control by dietary indoles
    GARY FIRESTONE; Fiscal Year: 2008
    ..This information will be particularly valuable to develop new classes of I3C-based therapeutics for reproductive cancers. ..
  40. Neuronal/Glial Interactions in Neuropathic Pain
    PETER OHARA; Fiscal Year: 2008
    ..These studies will serve to establish the role of neuron-glial cell communication in facial neuropathic pain...
  41. RADIOLOGICAL RESEARCH ACCELERATOR FACILITY (RARAF)
    David Brenner; Fiscal Year: 2002
    ..abstract_text> ..
  42. KINETICS AND MECHANISM OF THE HEAT SHOCK 70 PROTEIN DNAK
    STEPHAN WITT; Fiscal Year: 2002
    ..abstract_text> ..
  43. Novel Small-Molecule Inhibitors of the Tie2/Angiopoietin Interactions and Signali
    Dimitar Nikolov; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  44. MECHANISMS OF AUTOREACTIVITY IN SLE
    Robert Eisenberg; Fiscal Year: 2009
    ..Such insights should be readily translatable to human autoimmune diseases. ..
  45. Mechanical regulation of selectin-ligand binding kinetics
    Cheng Zhu; Fiscal Year: 2008
    ..As a result, the data may offer new therapeutic approaches to inhibiting pathological cell adhesion during inflammation and thrombosis. ..
  46. MECHANISM(S) CONTROLLING GROWTH/MEIOSIS SWITCH IN YEAST
    SAUL HONIGBERG; Fiscal Year: 2002
    ..To further examine this two-step control of differentiation, genes involved in nutritional control of late meiotic events are being identified, and their interactions with known meiotic regulators characterized (Specific Aim 3). ..
  47. NUMERICAL ANALYSIS OF FLOW AND TISSUE DEFORMATION
    Roger Kamm; Fiscal Year: 2001
    ..Specific Aim 3. To test the hypothesis that sites of inflammation/degradation correlate with regions within the tissue that experience high mechanical strain. ..
  48. BIOMECHANICAL EFFECT OF ACUPUNCTURE NEEDLING
    HELENE LANGEVIN; Fiscal Year: 2001
    ..This will contribute to the fundamental understanding of acupuncture therapy and may lead to improvements in treatments. ..
  49. TNFR Members in T Cell Immunity to Vaccinia
    Michael Croft; Fiscal Year: 2010
    ....
  50. Neural Crest Modulates FGF Signaling in the Pharynx
    Margaret Loewy Kirby; Fiscal Year: 2010
    ..Together these studies will advance the mechanistic understanding of neural crest function in heart development and will provide insight into factors that cause conotruncal malformations. ..
  51. POMC Processing and Beta-Endorphine-Related Opioid Peptides
    Vivian Y H Hook; Fiscal Year: 2010
    ..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
  52. RECEPTOR AGGREGATION AND ITS EFFECTS
    Byron Goldstein; Fiscal Year: 2002
    ..The studies in this project are health related, bearing on allergic reactions and their treatment as well as other aspects of the immune response. ..
  53. EXPRESSION OF HUMAN ERYTHROPOIETIN GENE
    Gregg Semenza; Fiscal Year: 2002
    ..abstract_text> ..
  54. The Role of Ductin in Embryonic Morphogenesis
    Michael Levin; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  55. Cellular Cardiomyoplasty in Vitro: Host-Donor Cell Interactions
    Nenad Bursac; Fiscal Year: 2007
    ..The final aim is to aid in the development of efficient and safe cell-based approaches for the treatment of regional heart injury due to ischemia, infarction, or congenital defects. [unreadable] [unreadable] [unreadable]..
  56. NTPDase2 expression and function in the liver
    JONATHAN DRANOFF; Fiscal Year: 2005
    ..The experiments proposed in these specific aims will provide the basis of several new lines of liver disease research and should provide novel therapeutic targets for treatment of cholestatic and fibrotic liver disease. ..
  57. Minimal Treatment Models of Stem Cell Engraftment
    Peter Quesenberry; Fiscal Year: 2004
    ..These studies should shed light on the stem cell/accessory cell mechanism involved in both syngeneic and allogeneic transplantation and provide approaches to minimize toxicity in both types of transplantation. ..
  58. MULTI-EPITOPE MELANOMA PEPTIDE VACCINATION WITH GM-CSF
    Craig Slingluff; Fiscal Year: 2004
    ..abstract_text> ..
  59. CGRP CONTROL IN TRIGEMINAL NEURONS IN VITRO AND IN VIVO
    Paul Durham; Fiscal Year: 2006
    ..abstract_text> ..
  60. Determination of Mechanism of T cell Lineage Committment
    Joonsoo Kang; Fiscal Year: 2006
    ..The long-term objective of this application is to identify genes that determine T cell lineage fate. ..
  61. Visualization of gamma delta T cells in wound healing
    WENDY HAVRAN; Fiscal Year: 2005
    ..Interesting initial results from this study will lead to new directions aimed at dissection of immune responses in epithelial tissues. ..
  62. High-Volume Confocal Imaging System
    Stephen Crews; Fiscal Year: 2005
    ..The Pascal will allow the labs to expeditiously and comprehensively study the cellular basis of embryonic development in combination with existing bright-field and spinning disk microscopes. ..
  63. CNS Lupus: Mechanistic Dissection
    Joseph Craft; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  64. Coordination of growth and patterning during development
    Laura Johnston; Fiscal Year: 2007
    ..abstract_text> ..
  65. Challenges in the Era of Stem Cell Plasticity
    Peter Quesenberry; Fiscal Year: 2003
    ..Participants will include investigators in the basic biology of stem cells, clinical transplanters, and clinician investigators. The workshops and symposium will be held in Providence, Rhode Island on April 8, 9, 10 & 11, 2003 ..
  66. Serpin Protease Inhibitors & Opioid Neuropeptides
    Vivian Hook; Fiscal Year: 2006
    ..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
  67. Avian Influenza Virus Vaccines Bearing Immunomodulators
    Paul Roberts; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  68. TRAINING IN CLINICAL INVESTIGATION FOR PHYSICIANS
    Joseph Craft; Fiscal Year: 2004
    ..The curriculum takes maximum advantage of the strong training environment already in place in the Medical School. ..
  69. GENETIC ANALYSIS OF T CELLS IN LUPUS
    Joseph Craft; Fiscal Year: 2010
    ..Delineation of the pathways that are required for the development and maintenance of systemic autoimmunity will ultimately help foster better understanding of T-B cell collaboration as a therapeutic target in SLE. ..
  70. Structure and mechanism of the AMP-activated protein kinase
    Lawrence Shapiro; Fiscal Year: 2010
    ..Our preliminary results and the further work proposed will provide high-resolution structural information on AMPK, and should directly enable the rational design of AMPK-directed therapeutics. ..
  71. HMG-1/Y Regulation of NOS2 Expression in Endotoxemia
    REBECCA BARON; Fiscal Year: 2007
    ..These experiments will allow us to determine the role of HMG-I/Y in regulating NOS2 expression during endotoxemia and may reveal a novel target for improving outcomes from sepsis. [unreadable] [unreadable] [unreadable]..
  72. Gamma Delta T Cell Conference
    WENDY HAVRAN; Fiscal Year: 2006
    ..Funds to support these goals will ensure that the 2006 gamma-delta T Cell Conference is an exciting forum for discussion of the latest information about gamma-delta T cells. ..
  73. Mice That Lack CDO: A Model for Mild Holoprosencephaly
    ROBERT KRAUSS; Fiscal Year: 2004
    ....
  74. Effects of Myostatin Deficiency on Bone Strength
    Mark Hamrick; Fiscal Year: 2007
    ..abstract_text> ..
  75. Ig-Reactive T Cells in Rheumatoid Arthritis
    Russell Salter; Fiscal Year: 2003
    ....
  76. Schwann Cell Spinal Remyelination in the Rat
    PETER OHARA; Fiscal Year: 2006
    ..abstract_text> ..
  77. CX43 IN A GENETIC MODEL OF ALTERED MYOCARDIAL CONDUCTION
    Jeffrey Saffitz; Fiscal Year: 2004
    ..The results of the proposed research will define mechanisms by which reduced coupling promotes ventricular tachyarrhythmias in mouse models of acute and chronic ischemic heart disease in patients. ..
  78. Diabetes, Inflammation and Vascular Disease
    Susan Smyth; Fiscal Year: 2004
    ..Moreover, our results may have broad implications for the treatment and prevent of accelerated atherosclerosis and thrombosis in diabetes. ..
  79. Hypoxia VHL nad HIF in Renal Tumor Development
    Volker Haase; Fiscal Year: 2008
    ..Ultimately they have the potential to create a murine model of VHL associated renal tumors. ..
  80. Updating Chromosome Aberration Simulator (CAS) Software
    Rainer Sachs; Fiscal Year: 2006
    ..An interdisciplinary team has been assembled for this project. The grant would ensure that a computer resource important to the radiation cytogenetics community is kept fully current and readily available. ..