cell adhesion

Summary

Summary: Adherence of cells to surfaces or to other cells.

Top Publications

  1. ncbi Epithelial-mesenchymal transitions in tumour progression
    Jean Paul Thiery
    Centre National Recherche Scientifique Unité Mixte Recherche, 144 Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Rev Cancer 2:442-54. 2002
  2. pmc Convergence of Wnt, beta-catenin, and cadherin pathways
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 303:1483-7. 2004
  3. pmc VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    Rosandra N Kaplan
    Department of Pediatrics and the Children s Blood Foundation Laboratories, Weill Cornell Medical College of Cornell University, New York, New York 10021, USA
    Nature 438:820-7. 2005
  4. ncbi Multifunctional strands in tight junctions
    S Tsukita
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Nat Rev Mol Cell Biol 2:285-93. 2001
  5. ncbi Identification of the haematopoietic stem cell niche and control of the niche size
    Jiwang Zhang
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Nature 425:836-41. 2003
  6. ncbi The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    A J Ridley
    Institute for Cancer Research, Chester Beatty Laboratories, London, England
    Cell 70:389-99. 1992
  7. ncbi Regulation of cadherin-mediated adhesion in morphogenesis
    Barry M Gumbiner
    Department of Cell Biology, University of Virginia, School of Medicine, PO Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Rev Mol Cell Biol 6:622-34. 2005
  8. pmc Growth factors, matrices, and forces combine and control stem cells
    Dennis E Discher
    Biophysical Engineering and Nanobiopolymers Laboratory, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 324:1673-7. 2009
  9. ncbi The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    J Comijn
    Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
    Mol Cell 7:1267-78. 2001
  10. ncbi Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures
    Oren M Tepper
    Laboratory of Microvascular Research and Vascular Tissue Engineering, Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, NY 10016, USA
    Circulation 106:2781-6. 2002

Detail Information

Publications316 found, 100 shown here

  1. ncbi Epithelial-mesenchymal transitions in tumour progression
    Jean Paul Thiery
    Centre National Recherche Scientifique Unité Mixte Recherche, 144 Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Rev Cancer 2:442-54. 2002
  2. pmc Convergence of Wnt, beta-catenin, and cadherin pathways
    W James Nelson
    Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Science 303:1483-7. 2004
    ..signaling pathway, beta-catenin, also functions as a component of the cadherin complex, which controls cell-cell adhesion and influences cell migration...
  3. pmc VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    Rosandra N Kaplan
    Department of Pediatrics and the Children s Blood Foundation Laboratories, Weill Cornell Medical College of Cornell University, New York, New York 10021, USA
    Nature 438:820-7. 2005
    ..These findings demonstrate a requirement for VEGFR1+ haematopoietic progenitors in the regulation of metastasis, and suggest that expression patterns of fibronectin and VEGFR1+VLA-4+ clusters dictate organ-specific tumour spread...
  4. ncbi Multifunctional strands in tight junctions
    S Tsukita
    Department of Cell Biology, Kyoto University Faculty of Medicine, Yoshida Konoe, Sakyo ku, Kyoto 606 8501, Japan
    Nat Rev Mol Cell Biol 2:285-93. 2001
    Tight junctions are one mode of cell-cell adhesion in epithelial and endothelial cellular sheets...
  5. ncbi Identification of the haematopoietic stem cell niche and control of the niche size
    Jiwang Zhang
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Nature 425:836-41. 2003
    ..We conclude that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of HSCs by regulating niche size...
  6. ncbi The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    A J Ridley
    Institute for Cancer Research, Chester Beatty Laboratories, London, England
    Cell 70:389-99. 1992
    ..These data imply that rho is essential specifically for the coordinated assembly of focal adhesions and stress fibers induced by growth factors...
  7. ncbi Regulation of cadherin-mediated adhesion in morphogenesis
    Barry M Gumbiner
    Department of Cell Biology, University of Virginia, School of Medicine, PO Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Rev Mol Cell Biol 6:622-34. 2005
    ..Signal-transduction pathways impinge on the catenins (cytoplasmic cadherin-associated proteins), which transduce changes across the membrane to alter the state of the cadherin adhesive bond...
  8. pmc Growth factors, matrices, and forces combine and control stem cells
    Dennis E Discher
    Biophysical Engineering and Nanobiopolymers Laboratory, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 324:1673-7. 2009
    ..Multifaceted technologies are increasingly required to produce and interrogate cells ex vivo, to build predictive models, and, ultimately, to enhance stem cell integration in vivo for therapeutic benefit...
  9. ncbi The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    J Comijn
    Molecular Cell Biology Unit, Department of Molecular Biology, VIB Ghent University, B 9000, Ghent, Belgium
    Mol Cell 7:1267-78. 2001
    ..SIP1 therefore appears to be a promoter of invasion in malignant epithelial tumors...
  10. ncbi Human endothelial progenitor cells from type II diabetics exhibit impaired proliferation, adhesion, and incorporation into vascular structures
    Oren M Tepper
    Laboratory of Microvascular Research and Vascular Tissue Engineering, Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, NY 10016, USA
    Circulation 106:2781-6. 2002
    ..Because diabetic complications occur in conditions in which EPC contributions have been demonstrated, EPC dysfunction may be important in their pathophysiology...
  11. ncbi Thrombomodulin-mediated cell adhesion: involvement of its lectin-like domain
    Huey Chun Huang
    Department of Biochemistry, College of Medicine, National Cheng Kung University, Tainan, Taiwan 701, Republic of China
    J Biol Chem 278:46750-9. 2003
    ..TM may also possess functions distinct from its anticoagulant activity. Here the influence of TM on cell adhesion was studied in TM-negative melanoma A2058 cells transfected with green fluorescent protein-tagged TM (TMG) or ..
  12. ncbi Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    Hector Peinado
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma de Madrid UAM, Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Nat Rev Cancer 7:415-28. 2007
    ....
  13. ncbi Tissue cells feel and respond to the stiffness of their substrate
    Dennis E Discher
    School of Engineering and Applied Science and Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, PA 19104 6315, USA
    Science 310:1139-43. 2005
    ..The feedback of local matrix stiffness on cell state likely has important implications for development, differentiation, disease, and regeneration...
  14. doi The tail of integrins, talin, and kindlins
    Markus Moser
    Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Science 324:895-9. 2009
    ..This review focuses on the mechanisms whereby two key proteins, talin and the kindlins, regulate integrin activation by binding the tails of integrin-beta subunits...
  15. doi Adhesion signaling - crosstalk between integrins, Src and Rho
    Stephan Huveneers
    Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands
    J Cell Sci 122:1059-69. 2009
    ..We also discuss how this signaling network can regulate a range of cellular processes that are important for normal tissue function and disease, including cell adhesion, spreading, migration and mechanotransduction.
  16. ncbi TGF-beta and epithelial-to-mesenchymal transitions
    Jiri Zavadil
    Department of Pathology, NYU Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
    Oncogene 24:5764-74. 2005
    ..Here we will review the distinct physiological contexts of EMT and the underlying molecular signaling networks controlled by TGF-beta...
  17. pmc Non-muscle myosin II takes centre stage in cell adhesion and migration
    Miguel Vicente-Manzanares
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Nat Rev Mol Cell Biol 10:778-90. 2009
    ..Owing to its position downstream of convergent signalling pathways, NM II is central in the control of cell adhesion, cell migration and tissue architecture...
  18. ncbi The third dimension bridges the gap between cell culture and live tissue
    Francesco Pampaloni
    Francesco Pampaloni, Emmanuel G Reynaud and Ernst H K Stelzer are at the Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Nat Rev Mol Cell Biol 8:839-45. 2007
    ..We believe that 3D cultures will have a strong impact on drug screening and will also decrease the use of laboratory animals, for example, in the context of toxicity assays...
  19. ncbi Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates
    N Q Balaban
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Nat Cell Biol 3:466-72. 2001
    Mechanical forces play a major role in the regulation of cell adhesion and cytoskeletal organization...
  20. doi Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes
    Maria Yanez-Mo
    Servicio de Inmunologia, Hospital Universitario de la Princesa, UAM C Diego de León 62, 28006, Madrid, Spain
    Trends Cell Biol 19:434-46. 2009
    ..This review explores this emerging picture of tetraspanin microdomains and discusses the implications for cell adhesion, proteolysis and pathogenesis.
  21. pmc The extracellular matrix: not just pretty fibrils
    Richard O Hynes
    Howard Hughes Medical Institute, David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 326:1216-9. 2009
    ..As organized, solid-phase ligands, ECM proteins can integrate complex, multivalent signals to cells in a spatially patterned and regulated fashion. These properties need to be incorporated into considerations of the functions of the ECM...
  22. ncbi Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
    M Uehata
    Discovery Research Tokyo, Yoshitomi Pharmaceutical Industries Ltd, Saitama, Japan
    Nature 389:990-4. 1997
    ..Our findings indicate that p160ROCK-mediated Ca2+ sensitization is involved in the pathophysiology of hypertension and suggest that compounds that inhibit this process might be useful therapeutically...
  23. ncbi Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo, 160 8582, Japan
    Cell 118:149-61. 2004
    ..These data suggest that the Tie2/Ang-1 signaling pathway plays a critical role in the maintenance of HSCs in a quiescent state in the BM niche...
  24. ncbi CD44: from adhesion molecules to signalling regulators
    Helmut Ponta
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, PO Box 3640, 76021 Karlsruhe, Germany
    Nat Rev Mol Cell Biol 4:33-45. 2003
    ..CD44 and its associated partner proteins monitor changes in the extracellular matrix that influence cell growth, survival and differentiation...
  25. pmc A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
    Jennifer M Burns
    ChemoCentryx, Inc, Mountain View, CA 94043, USA
    J Exp Med 203:2201-13. 2006
    ....
  26. pmc Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome
    Lucy B Ochola
    KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Kilifi, Kenya
    PLoS ONE 6:e14741. 2011
    ..Our results show that increased binding to CD36 is associated with uncomplicated malaria while ICAM-1 adhesion is raised in parasites from cerebral malaria cases...
  27. pmc Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis
    Muhammad H Zaman
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Proc Natl Acad Sci U S A 103:10889-94. 2006
    ..Although biochemical factors such as adhesion receptor and ligand concentration and binding, signaling through cell adhesion complexes, and cytoskeletal structure assembly/disassembly have been studied in detail in a 2D context, the ..
  28. pmc Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner
    Colin K Choi
    Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA
    Nat Cell Biol 10:1039-50. 2008
    ..From these studies, we have developed a model for adhesion assembly that clarifies the relative contributions of myosin II and actin polymerization and organization...
  29. ncbi Rho GTPases and the actin cytoskeleton
    A Hall
    Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Science 279:509-14. 1998
    ....
  30. doi Rapid leukocyte migration by integrin-independent flowing and squeezing
    Tim Lämmermann
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany
    Nature 453:51-5. 2008
    ..Myosin II-dependent contraction is only required on passage through narrow gaps, where a squeezing contraction of the trailing edge propels the rigid nucleus...
  31. doi E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer
    Otto Schmalhofer
    Department of Visceral Surgery, University of Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany
    Cancer Metastasis Rev 28:151-66. 2009
    ..g. ZEB1. Consequences of a loss of E-cadherin are an impairment of cell-cell adhesion, which allows detachment of cells, and nuclear localization of beta-catenin...
  32. pmc Structural basis of integrin regulation and signaling
    Bing Hao Luo
    The CBR Institute for Biomedical Research, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 25:619-47. 2007
    Integrins are cell adhesion molecules that mediate cell-cell, cell-extracellular matrix, and cell-pathogen interactions...
  33. ncbi Integrins: bidirectional, allosteric signaling machines
    Richard O Hynes
    Howard Hughes Medical Institute, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 110:673-87. 2002
    ..Long-range conformational changes couple these functions via allosteric equilibria...
  34. pmc Vinculin controls focal adhesion formation by direct interactions with talin and actin
    Jonathan D Humphries
    Wellcome Trust Centre for Cell Matrix Research, University of Manchester, Manchester M13 9PT, England, UK
    J Cell Biol 179:1043-57. 2007
    ..The vinculin tail, however, is responsible for the functional link of FAs to the actin cytoskeleton. We propose a new model that explains how vinculin orchestrates FAs...
  35. ncbi New signals from the invasive front
    Gerhard Christofori
    Department of Clinical Biological Sciences, Center of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Nature 441:444-50. 2006
    ....
  36. pmc Plasticity of cell migration: a multiscale tuning model
    Peter Friedl
    Department of Cell Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, 6500 HB Nijmegen, Netherlands
    J Cell Biol 188:11-9. 2010
    ..The tuning model provides a matrix of parameters that control cell movement as an adaptive and interconvertible process with relevance to different physiological and pathological contexts...
  37. pmc Collective chemotaxis requires contact-dependent cell polarity
    Eric Theveneau
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Dev Cell 19:39-53. 2010
    ....
  38. pmc Balancing forces: architectural control of mechanotransduction
    Christopher C DuFort
    Department of Surgery and Center for Bioengineering and Tissue Regeneration, University of California, San Francisco UCSF, CA, USA
    Nat Rev Mol Cell Biol 12:308-19. 2011
    ....
  39. ncbi The matrix corroded: podosomes and invadopodia in extracellular matrix degradation
    Stefan Linder
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Pettenkoferstr 9, 80336 Munchen, Germany
    Trends Cell Biol 17:107-17. 2007
    ..This review highlights important new developments in the field, discusses the common and divergent features of podosomes and invadopodia and summarizes current knowledge about matrix-degrading proteinases at these structures...
  40. pmc Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis
    Cory L Simpson
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nat Rev Mol Cell Biol 12:565-80. 2011
    ..These architectural components are more than just rivets and scaffolds - they are active participants in epidermal morphogenesis that regulate epidermal polarization, signalling and barrier formation...
  41. ncbi The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors
    Victoria Bolós
    Instituto de Investigaciones Biomedicas Alberto Sols CSIC UAM, Arturo Duperier, 4, 28029 Madrid, Spain
    J Cell Sci 116:499-511. 2003
    ....
  42. ncbi Podosomes: adhesion hot-spots of invasive cells
    Stefan Linder
    Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten, Ludwig Maximilians Universitat, Pettenkoferstrasse 9, 80336 Munich, Germany
    Trends Cell Biol 13:376-85. 2003
    ..Here, we summarize and discuss the known structural, regulatory and functional features of podosomes, our aim being to stimulate further research into these unique structures...
  43. pmc Investigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family
    Joel H Janes
    Department of Global Health, University of Washington, Seattle, Washington, United States of America
    PLoS Pathog 7:e1002032. 2011
    ....
  44. ncbi Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
    Ugo Cavallaro
    Institute of Biochemistry and Genetics, Department of Clincal Biological Sciences, University of Basel Switzerland
    Nat Rev Cancer 4:118-32. 2004
  45. ncbi Wnt signaling: a common theme in animal development
    K M Cadigan
    Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University Medical Center, Stanford, California 94305 5323, USA
    Genes Dev 11:3286-305. 1997
  46. ncbi Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
    Tony Yeung
    Institute for Medicine and Engineering, University of Pennsylvania, PA 19104, USA
    Cell Motil Cytoskeleton 60:24-34. 2005
    ..These results support the hypothesis that mechanical factors impact different cell types in fundamentally different ways, and can trigger specific changes similar to those stimulated by soluble ligands...
  47. pmc Paxillin comes of age
    Nicholas O Deakin
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    J Cell Sci 121:2435-44. 2008
    Paxillin is a multi-domain scaffold protein that localizes to the intracellular surface of sites of cell adhesion to the extracellular matrix...
  48. ncbi Cadherins in development: cell adhesion, sorting, and tissue morphogenesis
    Jennifer M Halbleib
    Department of Biological Sciences, Stanford University, Stanford, California 94305, USA
    Genes Dev 20:3199-214. 2006
    Tissue morphogenesis during development is dependent on activities of the cadherin family of cell-cell adhesion proteins that includes classical cadherins, protocadherins, and atypical cadherins (Fat, Dachsous, and Flamingo)...
  49. ncbi The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    A J Ridley
    Institute for Cancer Research, Chester Beatty Laboratories, London, England
    Cell 70:401-10. 1992
    ..We propose that rac and rho are essential components of signal transduction pathways linking growth factors to the organization of polymerized actin...
  50. pmc Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival
    Hideki Kato
    Department of Medicine, Division of Nephrology, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Biol Chem 286:26003-15. 2011
    ..These results indicate that Wnt/Ctnnb1 signaling in podocytes plays a critical role in integrating cell adhesion, motility, cell death, and differentiation...
  51. doi Regulation of actin assembly associated with protrusion and adhesion in cell migration
    Christophe Le Clainche
    Laboratoire d Enzymologie et Biochimie Structurales, Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Physiol Rev 88:489-513. 2008
    ..III) focuses on the function and the regulation of major proteins (vinculin, talin, tensin, and alpha-actinin) that control the nucleation, the binding, and the barbed-end growth of actin filaments in adhesions...
  52. ncbi FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly
    Donna J Webb
    Department of Cell Biology, UVA School of Medicine, P O Box 800732, Charlottesville, Virginia 22908 0732, USA
    Nat Cell Biol 6:154-61. 2004
    ....
  53. pmc Nanoscale architecture of integrin-based cell adhesions
    Pakorn Kanchanawong
    National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 468:580-4. 2010
    ..The composite multilaminar protein architecture provides a molecular blueprint for understanding focal adhesion functions...
  54. pmc Mechanotransduction in vivo by repeated talin stretch-relaxation events depends upon vinculin
    Felix Margadant
    Research Centre of Excellence in Mechanobiology, National University of Singapore, Singapore
    PLoS Biol 9:e1001223. 2011
    ..We suggest that rearward moving actin filaments bind, stretch, and release talin in multiple, stochastic stick-slip cycles and that multiple vinculin binding and release cycles integrate pulling on matrices into biochemical signals...
  55. pmc The desmosome
    Emmanuella Delva
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cold Spring Harb Perspect Biol 1:a002543. 2009
    ..Although desmosomes are critical for maintaining stable cell-cell adhesion, emerging evidence indicates that they are also dynamic structures that contribute to cellular processes ..
  56. ncbi Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior
    Cedric Auffray
    Institut Nationale de la Santé et de la Recherche Médicale INSERM U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Federatif de Recherche Necker Enfants Malades, Paris, France
    Science 317:666-70. 2007
    ....
  57. doi Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes
    Zhi Jiang Zang
    Cellular and Molecular Research, National Cancer Centre, Singapore
    Nat Genet 44:570-4. 2012
    ..b>Cell adhesion was the most enriched biological pathway among the frequently mutated genes...
  58. doi The cell-cell adhesion molecule E-cadherin
    F van Roy
    Department for Molecular Biomedical Research, Molecular Cell Biology Unit, VIB, Technologiepark 927, 9052 Ghent, Belgium
    Cell Mol Life Sci 65:3756-88. 2008
    This review is dedicated to E-cadherin, a calcium-dependent cell-cell adhesion molecule with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer...
  59. ncbi Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex
    Yasuyuki Fujita
    Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, 13125 Berlin, Germany
    Nat Cell Biol 4:222-31. 2002
    ..Through dynamic recycling of E-cadherin, Hakai can thus modulate cell adhesion, and could participate in the regulation of epithelial--mesenchymal transitions in development or metastasis.
  60. doi Assembly and biological role of podosomes and invadopodia
    Mario Gimona
    Unit of Actin Cytoskeleton Regulation, Consorzio Mario Negri Sud, Department of Cell Biology and Oncology, Via Nazionale 8a, 66030 Santa Maria Imbaro Chieti, Italy
    Curr Opin Cell Biol 20:235-41. 2008
    ..The stage is now set to unravel their roles in the physiology and pathology of tissue plasticity and repair...
  61. ncbi Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion
    T Imai
    Shionogi Institute for Medical Science, Settsu, Japan
    Cell 91:521-30. 1997
    ..Thus, fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators, performing both adhesive and chemotactic functions...
  62. pmc Mechanical integration of actin and adhesion dynamics in cell migration
    Margaret L Gardel
    Institute for Biophysical Dynamics, University of Chicago, Chicago, Illinois 60637, USA
    Annu Rev Cell Dev Biol 26:315-33. 2010
    ....
  63. pmc A perinuclear actin cap regulates nuclear shape
    Shyam B Khatau
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 106:19017-22. 2009
    ..the overall shape of fibroblasts and find that the shape of the nucleus is tightly regulated by the underlying cell adhesion geometry...
  64. ncbi Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments
    Patrick T Caswell
    Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, Glasgow G61 1BD, UK
    Dev Cell 13:496-510. 2007
    ..These data indicate that Rab25 contributes to tumor progression by directing the localization of integrin-recycling vesicles and thereby enhancing the ability of tumor cells to invade the extracellular matrix...
  65. doi Collective cell migration
    Pernille Rørth
    Temasek Life Sciences Laboratory and Department of Biological Sciences, The National University of Singapore, Singapore
    Annu Rev Cell Dev Biol 25:407-29. 2009
    ..New properties that emerge from this connectivity can contribute to shaping, guiding, and ultimately ensuring tissue function...
  66. pmc EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt
    Kentaro Abe
    RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe 650 0047, Japan
    Proc Natl Acad Sci U S A 105:13-9. 2008
    The cadherin-catenin complex is the major machinery for cell-cell adhesion in many animal species. This complex in general associates with actin fibers at its cytoplasmic side, organizing the adherens junction (AJ)...
  67. doi Dynamic and static interactions between p120 catenin and E-cadherin regulate the stability of cell-cell adhesion
    Noboru Ishiyama
    Division of Signaling Biology, Ontario Cancer Institute, ON, Canada
    Cell 141:117-28. 2010
    ..domain (JMD) of the cadherin cytoplasmic tail is critical for the surface stability of cadherin-catenin cell-cell adhesion complexes...
  68. ncbi Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes
    L Osborn
    Biogen, Inc, Cambridge Center, Massachusetts 02142
    Cell 59:1203-11. 1989
    ..VCAM-1, which belongs to the immunoglobulin gene super-family, may be central to recruitment of mononuclear leukocytes into inflammatory sites in vivo...
  69. pmc Collective cell migration requires suppression of actomyosin at cell-cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6
    Cristina Hidalgo-Carcedo
    Tumour Cell Biology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Nat Cell Biol 13:49-58. 2011
    ..Depletion of DDR1, Par3, Par6 or RhoE leads to increased actomyosin contactility at cell-cell contacts, a loss of cell-cell cohesion and defective collective cell invasion...
  70. pmc Integration of contractile forces during tissue invagination
    Adam C Martin
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    J Cell Biol 188:735-49. 2010
    ..Thus, pulsed actomyosin contractions require a supracellular, tensile meshwork to transmit cellular forces to the tissue level during morphogenesis...
  71. pmc A core function for p120-catenin in cadherin turnover
    Michael A Davis
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232 6840, USA
    J Cell Biol 163:525-34. 2003
    ..elimination of epithelial, placental, neuronal, and vascular endothelial cadherins, and complete loss of cell-cell adhesion. ARVCF and delta-catenin were functionally redundant, suggesting that proper cadherin-dependent adhesion ..
  72. pmc Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments
    Adam J Engler
    School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cell Biol 166:877-87. 2004
    ..These findings have major implications for in vivo introduction of stem cells into diseased or damaged striated muscle of altered mechanical composition...
  73. ncbi Complexes of tetraspanins with integrins: more than meets the eye
    F Berditchevski
    CRC Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham, B15 2TA, UK
    J Cell Sci 114:4143-51. 2001
    ....
  74. doi A two-tiered mechanism for stabilization and immobilization of E-cadherin
    Matthieu Cavey
    Institut de Biologie du Développment de Marseille Luminy, UMR 6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
    Nature 453:751-6. 2008
    ..Uncoupling stability and mobility of E-cadherin complexes suggests that stable epithelia may remodel through the regulated mobility of very stable adhesive foci...
  75. doi Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens
    Steven M Pollard
    Wellcome Trust Centre for Stem Cell Research and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Cell Stem Cell 4:568-80. 2009
    ..A proof-of-principle live cell imaging-based chemical screen (450 FDA-approved drugs) identifies both differential sensitivities of GNS cells and a common susceptibility to perturbation of serotonin signaling...
  76. pmc Stem cell fate dictated solely by altered nanotube dimension
    Seunghan Oh
    Department of Materials Science and Engineering, University California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:2130-5. 2009
    ....
  77. pmc Critical role of Bcr1-dependent adhesins in C. albicans biofilm formation in vitro and in vivo
    Clarissa J Nobile
    Department of Microbiology, Columbia University, New York, New York, USA
    PLoS Pathog 2:e63. 2006
    ..Known adhesins Als1 and Hwp1 also contribute to biofilm formation, as does the novel protein Ece1...
  78. pmc Interactions of Candida albicans with epithelial cells
    Weidong Zhu
    Divison of Infectious Disease, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Cell Microbiol 12:273-82. 2010
    ..Future challenges include identifying the epithelial cell targets of adhesins and invasins, and determining the mechanisms by which C. albicans actively penetrates epithelial cells and induces epithelial cell damage...
  79. pmc Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling
    Julian Heuberger
    Max Delbruck Center for Molecular Medicine, 13125 Berlin, Germany
    Cold Spring Harb Perspect Biol 2:a002915. 2010
    ..beta-Catenin is an essential molecule both in cadherin-mediated cell adhesion and in canonical Wnt signaling...
  80. doi Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511
    Sergey Rodin
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Nat Biotechnol 28:611-5. 2010
    ..This xeno-free and feeder-free system may be useful for the development of cell lineages for therapeutic purposes...
  81. ncbi Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
    M Tamura
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
    Science 280:1614-7. 1998
    ..Overexpression of FAK partially antagonized the effects of PTEN. Thus, PTEN phosphatase may function as a tumor suppressor by negatively regulating cell interactions with the extracellular matrix...
  82. pmc Intercellular junction assembly, dynamics, and homeostasis
    Kathleen J Green
    Northwestern University Feinberg School of Medicine, Department of Pathology, R H Lurie Comprehensive Cancer Center, 303 E Chicago Ave Chicago, Illinois 60611, USA
    Cold Spring Harb Perspect Biol 2:a000125. 2010
    ..We will explore signaling and trafficking machineries that drive assembly and remodeling and how these mechanisms are co-opted in human disease...
  83. ncbi Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis
    Thomas Lecuit
    Institute of Developmental Biology of Marseille Luminy, UMR6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseille Cedex 09, France
    Nat Rev Mol Cell Biol 8:633-44. 2007
    ..In this context, a range of developmental phenomena can be explained by the regulation of cell surface tension...
  84. ncbi Rho GTPases and cell migration
    A J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, UK
    J Cell Sci 114:2713-22. 2001
    Cell migration involves dynamic and spatially regulated changes to the cytoskeleton and cell adhesion. The Rho GTPases play key roles in coordinating the cellular responses required for cell migration...
  85. ncbi Cell interactions with three-dimensional matrices
    Edna Cukierman
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
    Curr Opin Cell Biol 14:633-9. 2002
    Signaling and other cellular functions differ in three-dimensional compared with two-dimensional systems. Cell adhesion structures can evolve in vitro towards in-vivo-like adhesions with distinct biological activities...
  86. ncbi Flocculation, adhesion and biofilm formation in yeasts
    Kevin J Verstrepen
    Harvard University Bauer Center for Genomics Research, 7 Divinity Avenue, Room 104, Cambridge, MA 02138, USA
    Mol Microbiol 60:5-15. 2006
    ..In contrast, cell-cell adhesion (flocculation) is a desirable property of industrial Saccharomyces cerevisiae strains that allows the easy ..
  87. pmc IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation
    Hongen Wei
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, USA
    J Neuroinflammation 8:52. 2011
    ..Recent evidence shows that IL-6 has a crucial role in the development and plasticity of CNS...
  88. pmc A defined glycosaminoglycan-binding substratum for human pluripotent stem cells
    Joseph R Klim
    Cell and Molecular Biology Program, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Methods 7:989-94. 2010
    ..The peptides supported growth of eight pluripotent cell lines on a variety of scaffolds. Our results indicate that synthetic substrates that recognize cell-surface glycans can facilitate the long-term culture of pluripotent stem cells...
  89. ncbi Novel functions of vimentin in cell adhesion, migration, and signaling
    Johanna Ivaska
    VTT Medical Biotechnology, Itäinen Pitkäkatu 4C, FI 20520 Turku, Finland
    Exp Cell Res 313:2050-62. 2007
    ..The implicated novel vimentin functions have broad ramifications into many different aspects of cell physiology, cellular interactions, and organ homeostasis...
  90. ncbi Osteoblast adhesion on biomaterials
    K Anselme
    Institut de Recherche sur les Maladies du Squelette, Institut Calot, Berck sur Mer, France
    Biomaterials 21:667-81. 2000
    ..In both cases, an understanding of the phenomena of cell adhesion and, in particular, understanding of the proteins involved in osteoblast adhesion on contact with the ..
  91. ncbi VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation
    Dietmar Vestweber
    Max Planck Institute of Molecular Biomedicine, Röntgenstr 20, D 48149 Munster, Germany
    Arterioscler Thromb Vasc Biol 28:223-32. 2008
    ..This review will focus on recent new developments in understanding the role of VE-cadherin in controlling endothelial cell contacts and influencing endothelial cell behavior by various outside-in signaling processes...
  92. ncbi Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone
    Russell S Taichman
    Department of Periodontics, Prevention, and Geriatrics, and the Center for Biorestoration of Oral Health, School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109 1078, USA
    Cancer Res 62:1832-7. 2002
    ..Collectively, these results suggest that prostate cancers and perhaps other neoplasms may use the SDF-1/CXCR4 pathway to spread to bone...
  93. pmc ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow
    Lin Yang
    Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, NRB 752P, Boston, MA 02215, USA
    Blood 106:584-92. 2005
    ..In summary, ICAM-1 promotes junctional and nonjunctional TEM across inflamed vascular endothelium via distinct cytoplasmic tail associations...
  94. ncbi Rho and Rac take center stage
    Keith Burridge
    Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell 116:167-79. 2004
    ..We will describe how the activity of Rho proteins is regulated downstream from growth factor receptors and cell adhesion molecules by guanine nucleotide exchange factors and GTPase activating proteins...
  95. ncbi Gap junction adhesion is necessary for radial migration in the neocortex
    Laura A B Elias
    Neuroscience Graduate Program, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Nature 448:901-7. 2007
    ....
  96. pmc Vinculin potentiates E-cadherin mechanosensing and is recruited to actin-anchored sites within adherens junctions in a myosin II-dependent manner
    Quint le Duc
    Hubrecht Institute, University Medical Centre Utrecht, 3584 CT Utrecht, Netherlands
    J Cell Biol 189:1107-15. 2010
    ..These findings have implications for barrier function, morphogenesis, cell migration, and invasion and may extend to all soft tissues in which classical cadherins regulate cell-cell adhesion.
  97. pmc The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin
    Hilary A Kenny
    Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois 60637, USA
    J Clin Invest 118:1367-79. 2008
    ..These findings indicate that MMP-2 expressed by metastatic OvCa cells functionally regulates their attachment to peritoneal surfaces...
  98. pmc MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1
    Tamia A Harris
    Cellular and Molecular Medicine Program and Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 105:1516-21. 2008
    ..adhesion molecules, but cytokines activate endothelial cells to express adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1), which mediate leukocyte adherence to endothelial cells...
  99. ncbi The myofibroblast in wound healing and fibrocontractive diseases
    G Gabbiani
    Department of Pathology, CMU University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland
    J Pathol 200:500-3. 2003
    ..These factors also play important roles in the development of fibrocontractive changes, such as those observed in liver cirrhosis, renal fibrosis, and stroma reaction to epithelial tumours...
  100. ncbi Cell migration: integrating signals from front to back
    Anne J Ridley
    Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK
    Science 302:1704-9. 2003
    ....
  101. doi External forces control mitotic spindle positioning
    Jenny Fink
    Institut Curie, CNRS UMR 144, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Nat Cell Biol 13:771-8. 2011
    ..We propose that cells divide according to cues provided by their mechanical micro-environment, aligning daughter cells with the external force field...

Research Grants79

  1. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2013
    ..GBM by immunohistology, and characterize cell signaling by OPN-R in comparison to OPN-FL and OPN-L in terms of cell adhesion, cell proliferation, apoptosis, protein phosphorylation, gene expression and cytokine production...
  2. Antiphospholipid antibodies and lupus: new molecular targets for treatment
    Emilio B Gonzalez; Fiscal Year: 2013
    ..expression of tissue factor (TF), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), upregulation of cytokines [IL1b, IL6, IL8, ..
  3. Phage Display for Improved Peptide-based Tumor Targeting and Imaging Agents
    Susan L Deutscher; Fiscal Year: 2013
    ..gal-3) and its carbohydrate ligand Thomsen- Friedenreich (TF) antigen, which are involved in cancer cell adhesion and signaling...
  4. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
    ..A novel family of cell adhesion molecules (CAMs), the Synaptic Cell Adhesion Molecules (SynCAMs), has recently been proposed to mediate the ..
  5. PATHOPHYSIOLOGY OF THE ENDOTHELIUM
    Francis W Luscinskas; Fiscal Year: 2013
    ..of leukocyte recruitment and vascular permeability, both of which involve coordinated interactions of cell-cell adhesion/junctional molecules and the actin cytoskeleton...
  6. MECHANISMS OF RADIORESISTANCE AND CELL CYCLE PROGRESSION
    Howard B Lieberman; Fiscal Year: 2013
    ..as reduced intensity of phenotypes that reflect metastasis, including migration towards fibronectin, invasion, cell adhesion to various extracellular matrix proteins, and metastatic behavior in an in vivo model...
  7. Monocyte activation and the role of CD11c in obesity-linked metabolic syndrome
    Huaizhu Wu; Fiscal Year: 2013
    ..CD11c contributes to monocyte adhesion and migration on inflamed endothelial cells (ECs) by binding vascular cell adhesion molecule-1 (VCAM-1);and (3) deficiency of CD11c in obese mice reduces atherosclerosis and decreases AT ..
  8. RSK-2 regulates integrin-mediated adhesion and migration
    JOE WILLIAM RAMOS; Fiscal Year: 2013
    ..provided by applicant): The long-term goal of this project is to help determine the mechanisms that regulate cell adhesion and migration...
  9. Epithelial differentiation in cornea
    Bogi Andersen; Fiscal Year: 2012
    ..This research is likely to give new insights into both impaired epithelial cell adhesion and altered corneal epithelial differentiation -- features which characterize several diseases of the cornea, ..
  10. Tumor Cell Arrest and Adhesion in the Microcirculation
    Bingmei M Fu; Fiscal Year: 2013
    ..between microcirculation-induced mechanical factors, microvascular permeability (vascular integrity), cell adhesion molecules, nitric oxide and cytokines, and tumor metastasis in intact microvessels...
  11. The Regulation of Salivary Gland Regeneration by P2Y2 Nucleotide Receptors
    GARY ANDREW WEISMAN; Fiscal Year: 2013
    ..proliferation, integrin/extracellular matrix interactions, cytoskeletal rearrangements and the expression of cell adhesion molecules and tight junction proteins...
  12. Role of Vimentin in Pathogenesis of CNS Inflammation
    Sheng He Huang; Fiscal Year: 2013
    ..Vim has emerged as an organizer of a number of critical proteins involved in cell adhesion/migration and cell signaling...
  13. Sphingosine 1-phosphate receptors in vascular homeostasis and pathology
    TIMOTHY TUN HLA; Fiscal Year: 2012
    ..and Akt-coupled S1P1R is induced in angiogenic vessels, is required for tumor angiogenesis, orchestrates cell-cell adhesion molecule function, promotes vascular maturation/stabilization and inhibits vascular permeability...
  14. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2012
    ..matrix proteins such as fibronectin and integrins play fundamental roles during development by controlling cell adhesion, motility, and survival...
  15. The lymph node microenvionment in tumor metastasis
    Judith A Varner; Fiscal Year: 2012
    ..studies suggest that lymph node lymphangiogenesis directly promotes lymph node metastasis by enhancing tumor cell adhesion and extravasation into the node...
  16. The biology of blood-testis barrier dynamics
    C Yan Cheng; Fiscal Year: 2013
    ..This, in turn, poses a unique opportunity to transport a drug, such as a male contraceptive that disrupts cell adhesion, behind the BTB to exert its effects, if the mechanism(s) that regulates the timely opening of the BTB is ..
  17. Misregulation of receptor tyrosine kinase signaling in PKD
    Jordan A Kreidberg; Fiscal Year: 2013
    ..of epithelial cells with their underlying basement membrane (cell-matrix adhesion) or with each other (cell-cell adhesion); (4) alterations in epithelial cell polarity;and (5) abnormal ciliary function...
  18. Role of ciliary proteins in endothelial cells morphogenesis
    Carlo Iomini; Fiscal Year: 2010
    ..to perform in vitro functional assays such as capillary morphogenesis, sprout formation, cell proliferation, cell adhesion, and cell migration. EC exposed to hemodynamic forces undergo significant morphogenetic changes...
  19. ECM compliance and cell cycle control
    RICHARD ASSOIAN; Fiscal Year: 2012
    ..but the approaches that have been used to document ECM/integrin effects typically rely on inhibition of cell adhesion, actin polymerization, or Rho-Rho kinase signaling using cells cultured on rigid plastic or glass surfaces ..
  20. Tick-Mammal Interface of Human Granulocytic Anaplasmosis
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
    ..2) Whole genome expression arrays probed with Ap mRNA during specific steps in their life cycle (host cell adhesion, invasion, replication, exit) will identify key genes involved in these processes...
  21. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..The cadherin Neural Cell Adhesion Molecule (NCAM) is key in leukocyte adhesion to endothelial cells...
  22. Thrombospondin 4 A1
    JOHN W LAWLER; Fiscal Year: 2010
    ..We hypothesize that wild-type COMP promotes cell adhesion, migration, proliferation and survival, while suppressing apoptosis...
  23. Matrix Otopathology
    MICHAEL ANNE NMI GRATTON; Fiscal Year: 2011
    ..a critical role in cell migration and cell maturation, while in mature tissue they contribute to processes of cell adhesion, polarization and permeability...
  24. Phospholipid flip-flop in biogenic membranes
    Anant K Menon; Fiscal Year: 2013
    ..These molecules include glycoproteins such as the neural cell adhesion molecule, GPI-anchored proteins such as acetylcholinesterase, glycolipids such as the receptor for cholera ..
  25. SIGNALING THROUGH RHO GTP/GDP EXCHANGE FACTORS
    Philip B Wedegaertner; Fiscal Year: 2013
    ..Cellular processes under the control of Rho GTPases include smooth muscle cell contractility, cell adhesion, cell migration, cell proliferation, neurite extension and retraction, gene expression and cell division...
  26. Structure and function of stress fibers and cell adhesion sites
    Mary C Beckerle; Fiscal Year: 2013
    ....
  27. Analyzing Anthrax Toxins in Drosophilia
    Ethan Bier; Fiscal Year: 2013
    ..By inhibiting endocytic recycling, anthrax toxins also reduce levels of cell adhesion molecules (e.g., cadherins) and signaling proteins (e.g...
  28. STRUCTURE AND FUNCTION OF PAXILLIN
    Christopher E Turner; Fiscal Year: 2012
    ..It is a highly dynamic process requiring exquisite spatial and temporal control of cell adhesion to the extracellular matrix (ECM) in coordination with remodeling of the actin cytoskeleton...
  29. CEACAM1: A link between metabolic and cardiovascular diseases
    Sonia M Najjar; Fiscal Year: 2013
    ..The CarcinoEmbryonic Antigen-related Cell Adhesion Molecule-1 (CEACAM1) regulates insulin sensitivity by promoting insulin clearance in liver...
  30. A PANHYPOPITUITARY MOUSE MUTATION
    Sally A Camper; Fiscal Year: 2013
    ..3) Additional Prop1 target genes regulate changes in cell adhesion and migration that are akin to epithelial to mesenchymal transition, a process involved in normal organ ..
  31. Retinal Imaging of Prognostic Indicators of Atherosclerosis
    Frederick R Haselton; Fiscal Year: 2010
    ..late stage" plaque which is more likely to rupture, whereas certain proteins on the vessel wall, the cell adhesion molecules, may signal "early warning signs" to start treatment to curb risks...
  32. Role of the Tail Domain in Vinculin Function
    Sharon L Campbell; Fiscal Year: 2010
    ..mechanical linker between transmembrane integrin receptors and the actin cytoskeleton through association with cell adhesion molecules...
  33. Pregnancy, Pre-eclampsia, Anti-oxidants and Endothelial Cell Function
    Gautam Chaudhuri; Fiscal Year: 2010
    ..e. vascular cell adhesion molecule-1 (VCAM-1), and other adhesion molecules...
  34. The Role of Beta-Gal Mediated Interactions in Prostate Cancer Metastasis
    VLADISLAV V GLINSKII; Fiscal Year: 2013
    ..galectin-3 (Gal-3) are likely to play a leading role in initiating and supporting metastatic prostate cancer cell adhesion to microvascular endothelium...
  35. N-Glycosylation And ER Stress
    MARK LEHRMAN; Fiscal Year: 2012
    ..are secreted (such as immunoglobulins and polypeptide hormones) or present at the cell surface (including cell adhesion molecules and signaling receptors) are produced and folded by the endoplasmic reticulum (ER)...
  36. Plexin signalling in melanocyte biology and melanoma progression
    Glynis A Scott; Fiscal Year: 2013
    ..receptors (Plexins and Neuropilins) are widely distributed and regulate multiple biologic processes, including cell adhesion and migration, neurite extension, immune function, organogenesis, and tumor progression...
  37. Regulatory Mechanisms of Oxidative Stress in Cardiac Angiogenesis Postinfarction
    Yao Sun; Fiscal Year: 2013
    ..of angiogenic integrins, thereby activating the integrin signaling pathway and promoting endothelial cell adhesion and migration...
  38. Novel Erythroid Cell Membrane Protein
    Emery H Bresnick; Fiscal Year: 2010
    ..Although mFam55B has minor sequence similarity to Intercellular Cell Adhesion Molecule-4 (ICAM4), which is implicated in formation of functionally important erythroblastic islands, the ..
  39. Distinct roles of CARP target genes in wound healing
    Karinna Almodóvar; Fiscal Year: 2013
    ..application is that CARP protein regulates the transcription of genes coding for matrix-degrading proteases, cell adhesion molecules, and other genes associated with the process of ECM remodeling and capillary morphogenesis during ..
  40. Oncogenic Kit receptor signaling in vivo
    Peter Besmer; Fiscal Year: 2012
    ..Normal Kit receptor mediated functions include cell proliferation, cell survival, cell adhesion, cell migration, secretory responses and differentiation...
  41. A search for genes that regulate allogeneic stem cell competition
    Irving L Weissman; Fiscal Year: 2013
    ..stem cells (Tie1 and Tek), and sequence and structural homology to genes involved in NK cell signaling and cell adhesion (CD155 and Igsf4) implicating NK-like cells as mediators of this primitive recognition system...
  42. Calcium-sensing Receptor and Keratinocyte Differentiation
    Chia Ling Tu; Fiscal Year: 2013
    ..Ca2+o concentration triggers an increase in the level of intracellular free Ca2+ (Ca2+i) and induces cell-cell adhesion, two key signaling events promoting keratinocyte differentiation...
  43. Chronic stress-induced gene expression in colonic circular smooth muscle cells.
    Sushil K Sarna; Fiscal Year: 2012
    ..The inflammatory response is mediated by cytokines, chemokines and cell adhesion molecules...
  44. Analysis of alphaVbeta8 Integrin In Gliomagenesis
    Joseph H McCarty; Fiscal Year: 2012
    ..In this project we will study how cell adhesion molecules, known as integrins, regulate the onset and progression of gliomas in mice and humans...
  45. Regulation and Function of the Matricellular Protein CCN1 in Ischemic Retinopathy
    Brahim Chaqour; Fiscal Year: 2013
    ..protein expression and/or activity, thereby triggering signaling events that culminate in the regulation of cell adhesion, migration, proliferation, gene expression, differentiation, and survival...
  46. Catenins: A role in spertmatogenesis and sperm maturation
    MANJEET KUMAR RAO; Fiscal Year: 2010
    ..expressed in the germ cells and Sertoli cells, to play an important role in regulating germ cell- Sertoli cell adhesion at the apical ES...
  47. Network modeling of epithelial mesenchymal transition in liver cancer metastasis
    Steven N Steinway; Fiscal Year: 2013
    ..After EMT, liver epithelial cells become motile, mesenchymal cells and lose cell-to-cell adhesion, which allows for the migration from the primary tumor site...
  48. Dose Ranging study of the Effects of Alpha Acid on Oxidative Stress
    Pamela Ouyang; Fiscal Year: 2010
    ..Lipoic acid also suppresses the endothelial cell NF-kappaB activation and the expression of cell adhesion molecules by advanced glycation end-products...
  49. Regulation of colitis by orphan nuclear receptor Nur77
    Dezheng Zhao; Fiscal Year: 2013
    ..Activated IMEC secrete various pro- inflammatory mediators and express cell-cell adhesion molecules that facilitate leukocyte infiltration...
  50. Flow-induced coronary vasospasm in diabetic patients
    Zsolt Bagi; Fiscal Year: 2013
    ..I also hypothesize that stimulation of platelet endothelium cell adhesion molecule -1 (Pecam-1, known as primary flow sensor in endothelium) with increases in intraluminal flow ..
  51. Cath B and uPAR si RNA constructs regressed glioma growth
    JOHN P O'BRYAN; Fiscal Year: 2013
    ..Evaluate the effect of vectors expressing siRNA targeting cathepsin B and uPAR (pCU) on glioma cell adhesion, migration and invasion in in vitro models with and without radiation. Aim 1a...
  52. Analyzing the Efficacy of Galectin-1 Ligand Inhibition in Adoptive T cell Therapy
    JENNA GEDDES SWEENEY; Fiscal Year: 2012
    ..Gal-1 is involved in cell adhesion, migration, and apoptosis. In addition, Gal-1 has been found to be associated with a variety of cancers...
  53. Obesity, vascular inflammation, and immune cell activation in prehypertension
    Suzi Hong; Fiscal Year: 2013
    ..vascular inflammation and immune cell activation by assessing levels of: endothelin-1, soluble endothelial cell adhesion molecules (CAM), plasma inflammatory cytokines, CAM expression on immune cells, cytokine producing cells upon ..
  54. The Role of PcpA in the Mechanism of Virulence and Protective Immunity.
    MELISSA MARIE WALKER; Fiscal Year: 2013
    ..Other proteins belonging to the LRR super family have a variety of functions such as cell adhesion, signaling, RNA processing, and extra cellular matrix assembly...
  55. Competetive Renewal of MSM: Multiscale Studies of Segmentation in Vertebrates
    Claudio D Stern; Fiscal Year: 2013
    ..However, little is known about how (or if) these molecular players relate to cell behaviors like cell adhesion, proliferation and migration that result in somite patterning...
  56. A Novel IgE Cancer Therapeutic Specific for the Epithelial Membrane Protein-2
    TRACY RUTH DANIELS-WELLS; Fiscal Year: 2013
    ..The epithelial membrane protein-2 (EMP2) is a tetraspan membrane protein involved in cell adhesion, invasion, and signal transduction through the regulation of cell membrane composition...
  57. HTS platform for identification of regulators of cell adhesion molecule signaling
    Darren G Woodside; Fiscal Year: 2013
    ..Integrin cell adhesion receptors play essential roles in normal physiologic process and have been implicated in neoplasia, ..
  58. Regulation of orofacial ectodermal polarity by the CLP protein, IRF6
    EMILY YIN CHU; Fiscal Year: 2013
    ..e. polarity), ultimately impacting epithelial cell adhesion, shape, and behavior...
  59. Systems Biology of Glycosylation
    Sriram Neelamegham; Fiscal Year: 2013
    ..Defined and specific perturbation of these rate-limiting steps can reduce leukocyte-endothelial cell adhesion/migration in vivo during inflammation...
  60. ABNORMAL BIGH3 AGGREGATIONS IN CORNEAL DYSTROPHIES
    Andrew J W Huang; Fiscal Year: 2011
    bIGH3 (keratoepithelin) is a constituent of the extracellular matrix (ECM) responsible for cell adhesion. Several autosomal dominant corneal dystrophies are attributed to more than 30 missense mutations of the bIGH3 gene in 5q31 in ..
  61. Axon Guidance in the Olfactory System
    DIEGO JAVIER RODRIGUEZ-GIL; Fiscal Year: 2013
    ..Axon guidance cues, cell adhesion molecules, and odor receptor induced activity have all been implicated in the precise final targeting of OSN ..
  62. Metabolic &Developmental Aspects of Intellectual Disability
    Mary C McKenna; Fiscal Year: 2013
    ..Project IV focuses on the effects of H/l on lipid raft-protein interactions and function of the LI cell adhesion molecule, a key protein involved in neurite outgrowth, neuronal plasticity, and signal transduction pathways...
  63. Development of an Anti-PSGL-1 Antibody to Treat Crohn's Disease
    Scott A Rollins; Fiscal Year: 2011
    ..mediates the first step in the recruitment of leukocytes to sites of inflammation by binding to selectins, cell adhesion molecules that are upregulated in Crohn's Disease patients...
  64. Polarization and directed cell movements in engineered cellular environments
    Deborah E Leckband; Fiscal Year: 2010
    ..If successful, the proposed strategies in this R21 proposal will uniquely identify mechanisms governing cell adhesion and chemotaxis in cancer and in development...
  65. TYPE IV COLLAGEN IN MELANOMA CELL INVASION & METASTASIS
    James McCarthy; Fiscal Year: 1999
    ..Despite the well established role for laminin in promoting tumor cell adhesion, there is also an important role for type IV collagen in mediating the adhesion, migration and invasion of ..
  66. Neuroligin Regulation of Central GABAergic Synapses
    Zhanyan Fu; Fiscal Year: 2010
    ..is to identify molecular mechanisms underlying the regulation of inhibitory synaptic transmission by the cell adhesion molecule (CAM) neuroligin 2 (NL2)...
  67. ALCOHOL INTERACTION WITH L1 CELL ADHESION MOLECULE
    MICHAEL CHARNESS; Fiscal Year: 1999
    ..callosum are observed both in fetal alcohol syndrome (FAS) and in children with mutations in the gene for the cell adhesion molecule (CAM) L1...
  68. Functions, Traffic and Targeting of Fungal Adhesins
    SCOTT ERDMAN; Fiscal Year: 2003
    ..Components found in the cell wall also regulate cell-cell adhesion reactions such as flocculation during vegetative growth, sexual agglutination and pathogen-host cell adhesion...
  69. Desmoglein 2 Function in Cell Adhesion and Pemphigus
    MY MAHONEY; Fiscal Year: 2003
    ..are held together by intercellular junctions called desmosomes, which are critical for the maintenance of cell-cell adhesion, tissue integrity, and organ function...
  70. FLOW CYTOMETRY, SAMPLE HANDLING AND CELL ADHESION
    Larry Sklar; Fiscal Year: 2003
    ..Some approaches to examine molecular recognition, cell adhesion and cell activation are available...
  71. MOLECULAR MECHANISMS IN METASTASIS--ROLE OF FIBRONECTIN
    LEO FURCHT; Fiscal Year: 2001
    DESCRIPTION: (adapted from the investigator's abstract) Cell adhesion is a fundamental consideration in tumor cell metastasis...
  72. FLOW CYTOMETRY, SAMPLE HANDLING AND CELL ADHESION
    Larry Sklar; Fiscal Year: 2002
    ..Some approaches to examine molecular recognition, cell adhesion and cell activation are available...
  73. ALCOHOL AND CELL ADHESION
    MICHAEL EDWARD CHARNESS; Fiscal Year: 2010
    Ethanol inhibits cell adhesion mediated by the L1 cell adhesion molecule in neural cells and in fibroblasts ransfected with human L1...
  74. Molecular Function of Palladin's Ig Domains in Cell Adhesion and Motility
    Carol A Otey; Fiscal Year: 2010
    ..gene is mutated in a form of inherited pancreatic cancer, which is a disease characterized by a loss of cell-cell adhesion and disregulated, actin-dependent, invasive cell motility...
  75. Nanoscale patterning that promotes cell adhesion
    HEATHER MAYNARD; Fiscal Year: 2006
    ..DO NOT EXCEED THE SPACE PROVIDED. Project Summary. Cell adhesion is governed by interactions of cell surface receptors with proteins found in the extracellular matrix (ECM)...
  76. GLYCOLIPID E-SELECTIN LIGANDS ON HUMAN GRANULOCYTES
    Bruce Bochner; Fiscal Year: 2003
    ..expressed de novo on activated endothelial cells, is a selectin adhesion protein which mediates cell-cell adhesion early in this immune response by binding to leukocyte surface glycoconjugates...
  77. CELL ADHESION INDUCED DIFFERENTIATION IN EYE TISSUE
    JAMES MARRS; Fiscal Year: 2000
    ..Cadherins are calcium dependent cell-cell adhesion molecules that are essential for mammalian development...
  78. HOMEOBOX GENES AND CONGENITAL MALFORMATION OF THE LUNG
    MaryAnn Volpe; Fiscal Year: 2002
    ..of the proposed work is that Hoxb-5 controls normal airway branching morphogenesis through regulation of cell adhesion and extracellular matrix (ECM) molecules, and that abnormal airway development in BPS and CCAM involves mis-..
  79. LIGAND BONDING FORCE AND CELL ADHESION BY CD16 ISOFORMS
    Cheng Zhu; Fiscal Year: 1999
    ..property, and cellular function of CD16 and to use CD16 as a model to investigate receptor-mediated cell-cell adhesion. CD16 is a Fc receptor for immunoglobulin 6 (Fc-gammaRIII) that is vital to the immune system...