weaning

Summary

Summary: Permanent deprivation of breast milk and commencement of nourishment with other food. (From Stedman, 25th ed)

Top Publications

  1. ncbi Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets
    S Pie
    Unité de Pharmacologie Toxicologie, Institut National de la Recherche Agronomique, 31931 Toulouse Cedex 9, France
    J Nutr 134:641-7. 2004
  2. pmc Early weaning stress impairs development of mucosal barrier function in the porcine intestine
    Feli Smith
    Department of Population Health and Pathobiology, North Carolina State University, Raleigh, 27606, USA
    Am J Physiol Gastrointest Liver Physiol 298:G352-63. 2010
  3. ncbi Escherichia coli in postweaning diarrhea in pigs: an update on bacterial types, pathogenesis, and prevention strategies
    John M Fairbrother
    The Escherichia coli Laboratory, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 Sicotte, Saint Hyacinthe, QC, Canada J2S 2M2
    Anim Health Res Rev 6:17-39. 2005
  4. pmc Timing of solid food introduction and risk of obesity in preschool-aged children
    Susanna Y Huh
    Division of Gastroenterology and Nutrition, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Pediatrics 127:e544-51. 2011
  5. pmc Effect of pre-weaning concentrate supplementation on peripheral distribution of leukocytes, functional activity of neutrophils, acute phase protein and behavioural responses of abruptly weaned and housed beef calves
    Eilish M Lynch
    Animal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre, Teagasc, Grange, Dunsany, CO, Meath, Ireland
    BMC Vet Res 8:1. 2012
  6. pmc Stabilization of the murine gut microbiome following weaning
    Patrick D Schloss
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA
    Gut Microbes 3:383-93. 2012
  7. ncbi Ultra-early weaning in piglets results in low serum IgA concentration and IL17 mRNA expression
    Benoit Levast
    Institut National de la Recherche Agronomique INRA, UR1282, Infectiologie Animale et Sante Publique, F 37380, Nouzilly, France
    Vet Immunol Immunopathol 137:261-8. 2010
  8. pmc Pre-weaning growth hormone treatment reverses hypertension and endothelial dysfunction in adult male offspring of mothers undernourished during pregnancy
    Clint Gray
    Liggins Institute and Gravida, National Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    PLoS ONE 8:e53505. 2013
  9. ncbi Oral treatment with probiotic Lactobacillus johnsonii NCC533 (La1) for a specific part of the weaning period prevents the development of atopic dermatitis induced after maturation in model mice, NC/Nga
    R Inoue
    Laboratory of Animal Science, Kyoto Prefectural University, Shimogamo, Kyoto, Japan
    Br J Dermatol 156:499-509. 2007
  10. ncbi Probiotics during weaning reduce the incidence of eczema
    Christina E West
    Department of Clinical Sciences, Pediatrics, Umea University, Umeå S 901 85, Sweden
    Pediatr Allergy Immunol 20:430-7. 2009

Detail Information

Publications310 found, 100 shown here

  1. ncbi Weaning is associated with an upregulation of expression of inflammatory cytokines in the intestine of piglets
    S Pie
    Unité de Pharmacologie Toxicologie, Institut National de la Recherche Agronomique, 31931 Toulouse Cedex 9, France
    J Nutr 134:641-7. 2004
    ..Changes in the cytokine network of the pig gut may be expected at weaning, because abrupt changes in dietary and environmental factors lead to important morphological and functional ..
  2. pmc Early weaning stress impairs development of mucosal barrier function in the porcine intestine
    Feli Smith
    Department of Population Health and Pathobiology, North Carolina State University, Raleigh, 27606, USA
    Am J Physiol Gastrointest Liver Physiol 298:G352-63. 2010
    ..Here, we show that stress associated with early weaning in pigs leads to impaired mucosal barrier function...
  3. ncbi Escherichia coli in postweaning diarrhea in pigs: an update on bacterial types, pathogenesis, and prevention strategies
    John M Fairbrother
    The Escherichia coli Laboratory, Faculte de Medecine Veterinaire, Universite de Montreal, 3200 Sicotte, Saint Hyacinthe, QC, Canada J2S 2M2
    Anim Health Res Rev 6:17-39. 2005
    ..To date, not a single strategy has proved to be totally effective and it is probable that the most successful approach on a particular farm will involve a combination of diet modification and other preventive measures...
  4. pmc Timing of solid food introduction and risk of obesity in preschool-aged children
    Susanna Y Huh
    Division of Gastroenterology and Nutrition, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Pediatrics 127:e544-51. 2011
    ..To examine the association between timing of introduction of solid foods during infancy and obesity at 3 years of age...
  5. pmc Effect of pre-weaning concentrate supplementation on peripheral distribution of leukocytes, functional activity of neutrophils, acute phase protein and behavioural responses of abruptly weaned and housed beef calves
    Eilish M Lynch
    Animal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre, Teagasc, Grange, Dunsany, CO, Meath, Ireland
    BMC Vet Res 8:1. 2012
    The effect of pre-weaning concentrate supplementation on peripheral distribution of leukocytes, functional activity of neutrophils, acute phase protein response, metabolic and behavioural response, and performance of abruptly weaned and ..
  6. pmc Stabilization of the murine gut microbiome following weaning
    Patrick D Schloss
    Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA
    Gut Microbes 3:383-93. 2012
    ..The first was observed in the 10 days following weaning and the second was observed by 15 days following weaning...
  7. ncbi Ultra-early weaning in piglets results in low serum IgA concentration and IL17 mRNA expression
    Benoit Levast
    Institut National de la Recherche Agronomique INRA, UR1282, Infectiologie Animale et Sante Publique, F 37380, Nouzilly, France
    Vet Immunol Immunopathol 137:261-8. 2010
    In pigs raised for meat production, weaning is a critical period because of related physiological perturbations and negative consequences on performance...
  8. pmc Pre-weaning growth hormone treatment reverses hypertension and endothelial dysfunction in adult male offspring of mothers undernourished during pregnancy
    Clint Gray
    Liggins Institute and Gravida, National Centre for Growth and Development, University of Auckland, Auckland, New Zealand
    PLoS ONE 8:e53505. 2013
    ..We have utilised a model of maternal undernutrition to examine the effects of pre-weaning growth hormone (GH) treatment on BP and vascular function in adulthood...
  9. ncbi Oral treatment with probiotic Lactobacillus johnsonii NCC533 (La1) for a specific part of the weaning period prevents the development of atopic dermatitis induced after maturation in model mice, NC/Nga
    R Inoue
    Laboratory of Animal Science, Kyoto Prefectural University, Shimogamo, Kyoto, Japan
    Br J Dermatol 156:499-509. 2007
    ..The inhibitory effect of probiotic bacteria on atopic dermatitis has been shown in human infants, but the mechanism is still unclear...
  10. ncbi Probiotics during weaning reduce the incidence of eczema
    Christina E West
    Department of Clinical Sciences, Pediatrics, Umea University, Umeå S 901 85, Sweden
    Pediatr Allergy Immunol 20:430-7. 2009
    ..In the present study, we evaluated the effects of feeding Lactobacillus F19 during weaning on the incidence of eczema and Th1/Th2 balance...
  11. ncbi Prevalence of swine Torque teno virus in post-weaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs in Spain
    Tuija Kekarainen
    Centre de Recerca en Sanitat Animal CReSA, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    J Gen Virol 87:833-7. 2006
    The present study was designed to investigate the prevalence of swine Torque teno virus (TTV) in post-weaning multisystemic wasting syndrome (PMWS)-affected and non-affected Spanish swine...
  12. ncbi Risk factors of early redialysis after weaning from postoperative acute renal replacement therapy
    Vin Cent Wu
    Department of Internal Medicine, National Taiwan University Hospital, 7 Chung Shan South Road, Taipei, Taiwan
    Intensive Care Med 34:101-8. 2008
    ..Although recovery of renal function is anticipated in patients with ARF, no data have been reported on successful weaning from acute dialysis.
  13. ncbi Gastrointestinal dysfunction induced by early weaning is attenuated by delayed weaning and mast cell blockade in pigs
    Adam J Moeser
    Center for Comparative Translational and Molecular Research, College of Veterinary Medicine, North Carolina State Univ, 4700 Hillsborough St, Raleigh, NC 27606, USA
    Am J Physiol Gastrointest Liver Physiol 293:G413-21. 2007
    Our previous work has demonstrated that weaning at 19 days of age has deleterious effects on mucosal barrier function in piglet intestine that are mediated through peripheral CRF receptor signaling pathways...
  14. ncbi The effect of age of introduction to lumpy solids on foods eaten and reported feeding difficulties at 6 and 15 months
    K Northstone
    J Hum Nutr Diet 14:43-54. 2001
    ..The study aimed to document the dietary patterns of infants and determine the development of feeding difficulties as perceived by the mother according to the age at which lumpy solids were introduced into the diet...
  15. ncbi Transient changes of transforming growth factor-beta expression in the small intestine of the pig in association with weaning
    Jie Mei
    Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong
    Br J Nutr 93:37-45. 2005
    It is well known that early weaning causes marked changes in intestinal structure and function, and transforming growth factor-beta (TGF-beta) is believed to play an important regulatory role in post-weaning adaptation of the small ..
  16. ncbi Pre-weaning performance and health of pigs born to cloned (fetal cell derived) swine versus non-cloned swine
    M Martin
    Albany Research Farm, 901 Carpenter Road, Albany, OH 45710, USA
    Theriogenology 62:113-22. 2004
    The objective of this study was to compare the pre-weaning performance of pigs derived from cloned versus non-cloned parents. Five cloned gilts and one cloned boar were used to produce five litters of pigs...
  17. pmc Effect of Mycoplasma hyopneumoniae colonization at weaning on disease severity in growing pigs
    Eduardo Fano
    Swine Disease Eradication Center, College of Veterinary Medicine, 385 Animal Science Veterinary Medicine Building, University of Minnesota, 1988 Fitch Avenue, St Paul, Minnesota 55108, USA
    Can J Vet Res 71:195-200. 2007
    To determine whether Mycoplasma hyopneumoniae colonization at weaning in off-site weaning systems is associated with the severity of respiratory disease due to this agent in growing pigs, we studied 20 groups, each group representing a ..
  18. ncbi Opposite effects of fasting on TGF-beta3 and TbetaRI distribution in the gastric mucosa of suckling and early weanling rats
    Daniela Ogias
    Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    Nutrition 26:224-9. 2010
    Our aim was to evaluate the effects of a dietary regimen (suckling or early weaning) and feeding status (fed or fasted) on the distribution of transforming growth factor-beta3 (TGF-beta3) and TGF receptor-I (TbetaRI) in the gastric ..
  19. ncbi Weaning affects the expression of heat shock proteins in different regions of the gastrointestinal tract of piglets
    Jean Claude David
    Ecole Nationale Superieure Agronomique de Rennes, Rennes Cedex, France
    J Nutr 132:2551-61. 2002
    ..Because these nutrients alleviate alterations of the intestine after weaning in pigs, this study was designed to obtain basic information on the expression of HSP 27, heat shock cognate 70 (..
  20. ncbi Neurobiological effects of neonatal maternal separation and post-weaning environmental enrichment
    Ana Laura Vivinetto
    Cátedra de Fisiología Animal Facultad de Ciencias Exactas Físicas y Naturales, Universidad Nacional de Cordoba, Av Vélez Sársfield 299 X5000JJC, Cordoba, Argentina
    Behav Brain Res 240:110-8. 2013
    ..Grooming behavior in the open field was found to be significantly lower in maternally separated animals, but post-weaning environmental enrichment completely reversed this tendency...
  21. ncbi Reproduction in captive common marmosets (Callithrix jacchus)
    Suzette D Tardif
    Southwest National Primate Research Center, Post Office Box 760549, San Antonio, Texas 78245 0549, USA
    Comp Med 53:364-8. 2003
    ..an overview of reproduction in the common marmoset, including basic reproductive life history, lactation and weaning, social housing requirements, and common problems encountered in the captive breeding of this species...
  22. ncbi Effects of feeding probiotics during weaning on infections and antibody responses to diphtheria, tetanus and Hib vaccines
    Christina E West
    Pediatrics, Department of Clinical Sciences, Umea University, Umea, Sweden
    Pediatr Allergy Immunol 19:53-60. 2008
    ..We aimed at determining the impact of Lactobacillus F19 (LF19) during weaning on infections and IgG antibody responses to routine vaccines...
  23. ncbi Factors associated with weaning practices in term infants: a prospective observational study in Ireland
    Roslyn C Tarrant
    School of Biological Sciences, Dublin Institute of Technology, Kevin Street, Dublin 8, Republic of Ireland
    Br J Nutr 104:1544-54. 2010
    ..However, in many countries, this recommendation is followed by few mothers, and earlier weaning onto solids is a commonly reported global practice...
  24. ncbi Stable carbon and nitrogen isotope values of bone and teeth reflect weaning age at the Medieval Wharram Percy site, Yorkshire, UK
    M P Richards
    Department of Archaeological Sciences, University of Bradford, Bradford, West Yorkshire BD7 1DP, United Kingdom
    Am J Phys Anthropol 119:205-10. 2002
    ..and teeth from a single site and population (Medieval Wharram Percy), undertaken to explore variations due to weaning in a past population...
  25. pmc Transcriptomic analysis of the stress response to weaning at housing in bovine leukocytes using RNA-seq technology
    Aran O'Loughlin
    Animal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre, Grange, Dunsany, Co Meath, Ireland
    BMC Genomics 13:250. 2012
    b>Weaning of beef calves is a necessary husbandry practice and involves separating the calf from its mother, resulting in numerous stressful events including dietary change, social reorganisation and the cessation of the maternal-offspring ..
  26. ncbi Maternal low-protein diet causes epigenetic deregulation of HMGCR and CYP7α1 in the liver of weaning piglets
    Rihua Cong
    Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, PR China
    J Nutr Biochem 23:1647-54. 2012
    ..LP piglets showed significantly lower body weight and liver weight at weaning, associated with decreased liver and serum cholesterol content...
  27. ncbi Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment
    Max Bielohuby
    Institute of Molecular Animal Breeding and Biotechnology, Ludwig Maximilians University, Munich, Germany
    Am J Physiol Endocrinol Metab 293:E139-46. 2007
    ..systematic analysis of adrenal gland growth using unbiased stereological methods in male and female mice from weaning to adulthood (weeks 3, 5, 7, 9, and 11) at the organ, compartment, and cellular levels...
  28. pmc Production of a subunit vaccine candidate against porcine post-weaning diarrhea in high-biomass transplastomic tobacco
    Igor Kolotilin
    Southern Crop Protection and Food Research Centre, Agriculture and Agri Food Canada, London, Ontario, Canada
    PLoS ONE 7:e42405. 2012
    Post-weaning diarrhea (PWD) in piglets is a major problem in piggeries worldwide and results in severe economic losses. Infection with Enterotoxigenic Escherichia coli (ETEC) is the key culprit for the PWD disease...
  29. ncbi Factors associated with very early weaning among primiparas intending to breastfeed
    M Avery
    University of Minnesota, Minneapolis 55455 0342, USA
    Matern Child Health J 2:167-79. 1998
    ..Predictors were demographic variables, Theory of Planned Behavior (TPB) variables, breastfeeding knowledge, and difficulties experienced during the first month...
  30. ncbi The development of the mucosal immune system pre- and post-weaning: balancing regulatory and effector function
    M Bailey
    School of Clinical Veterinary Science, University of Bristol, Langford, UK
    Proc Nutr Soc 64:451-7. 2005
    ..important periods of maximum exposure to novel antigens occur in the young animal, immediately after birth and at weaning. In both cases the antigenic composition of the intestinal contents can shift suddenly, as a result of a novel ..
  31. ncbi Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig
    Adam J Moeser
    Center for Comparative Translational and Molecular Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Am J Physiol Gastrointest Liver Physiol 292:G173-81. 2007
    b>Weaning in the piglet is a stressful event associated with gastrointestinal disorders and increased disease susceptibility...
  32. ncbi HIV transmission through breastfeeding: a study in Malawi
    P G Miotti
    Department of Epidemiology, Johns Hopkins School of Hygiene and Public Health, Baltimore, MD, USA
    JAMA 282:744-9. 1999
    ..Understanding the risk of human immunodeficiency virus (HIV) transmission through breastfeeding is essential for advising HIV-infected mothers and formulating public health policy recommendations...
  33. ncbi Nutritional management of gut health in pigs around weaning
    Jean Paul Lallès
    INRA, UMR1079, Rearing Systems, Animal and Human Nutrition, F 35590 Saint Gilles, France
    Proc Nutr Soc 66:260-8. 2007
    Early weaning of piglets is often accompanied by a severe growth check and diarrhoea. It is well established that this process is multi-factorial and that post-weaning anorexia and undernutrition are major aetiological factors...
  34. ncbi Detection of breastfeeding and weaning in modern human infants with carbon and nitrogen stable isotope ratios
    B T Fuller
    Research Laboratory for Archaeology and the History of Art, University of Oxford, Oxford OX1 3QJ, United Kingdom
    Am J Phys Anthropol 129:279-93. 2006
    ..1 per thousand in archaeological populations are not necessarily the result of the consumption of C(4)-based weaning foods such as maize or millet...
  35. ncbi A meta-analysis comparing the effect of PCV2 vaccines on average daily weight gain and mortality rate in pigs from weaning to slaughter
    Charlotte Sonne Kristensen
    Danish Agriculture and Food Council, Pig Research Centre, Vinkelvej 11, DK 8620 Kjellerup, Denmark
    Prev Vet Med 98:250-8. 2011
    ..the effect of PCV2 vaccination on the average daily weight gain (ADG) and on the mortality rate in pigs from weaning to slaughter...
  36. ncbi Nursing caries, linear hypoplasia, and nursing and weaning habits in Tanzanian infants
    M Matee
    Department of Microbiology, Muhimbili University College of Health Sciences, Dar-es-Salaam, Tanzania
    Community Dent Oral Epidemiol 22:289-93. 1994
    ..Risk factors such as breast feeding frequency and duration during day and night, bottle feeding and weaning habits were assessed through a structured interview with the mother...
  37. ncbi Cryptosporidium andersoni is the predominant species in post-weaned and adult dairy cattle in China
    Rongjun Wang
    The College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China
    Parasitol Int 60:1-4. 2011
    ..Thus, C. andersoni appears to be the dominant species in weaned dairy calves and heifers in China, in contrast with its common occurrence in adult cattle in other parts of the world...
  38. pmc Use of a prolactin-Cre/ROSA-YFP transgenic mouse provides no evidence for lactotroph transdifferentiation after weaning, or increase in lactotroph/somatotroph proportion in lactation
    Emma Castrique
    Henry Wellcome Labs for Integrative Neuroscience and Endocrinology, University of Bristol, Dorothy Hodgkin Building, Bristol, UK
    J Endocrinol 205:49-60. 2010
    ..away from the lactotroph phenotype has been reported to restore non-pregnant pituitary proportions after weaning. To attempt to confirm that a similar process occurs in mice, we generated and used a transgenic reporter mouse ..
  39. pmc Factors associated with weaning in full term and preterm infants
    M S Fewtrell
    MRC Childhood Nutrition Research Centre, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Arch Dis Child Fetal Neonatal Ed 88:F296-301. 2003
    The optimal age for the introduction of solid foods (weaning) in infants is poorly researched yet may have implications for both short and longer term health. Many parents do not comply with current guidelines.
  40. pmc Effect of abrupt weaning at housing on leukocyte distribution, functional activity of neutrophils, and acute phase protein response of beef calves
    E M Lynch
    Animal and Bioscience Research Department, Animal and Grassland Research and Innovation Centre, Teagasc, Grange, Dunsany, Co Meath, Ireland
    BMC Vet Res 6:39. 2010
    ..x Holstein-Friesian and Simmental x Holstein-Friesian dams respectively, were used to investigate the effect of weaning on total leukocyte and differential counts, neutrophil functional activity, lymphocyte immunophenotypes, and ..
  41. pmc Maternal separation with early weaning: a novel mouse model of early life neglect
    Elizabeth D George
    Yale University School of Medicine, Department of Psychiatry, New Haven, CT 06511, USA
    BMC Neurosci 11:123. 2010
    ..Maternal separation is a commonly used model of early life neglect, but has led to inconsistent results in the mouse...
  42. pmc Early life risk factors for obesity in childhood: cohort study
    John J Reilly
    University of Glasgow Division of Developmental Medicine, Yorkhill Hospitals, Glasgow G3 8SJ
    BMJ 330:1357. 2005
    ..To identify risk factors in early life (up to 3 years of age) for obesity in children in the United Kingdom...
  43. ncbi Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice
    Maqsood M Elahi
    Institute of Developmental Sciences, Developmental Origins of Health and Disease Division, University of Southampton School of Medicine, Southampton General Hospital, Mailpoint 887, Southampton SO16 6YD, UK
    Br J Nutr 102:514-9. 2009
    ..in C57 mice the effects on offspring of feeding their mothers a high-fat (HF) or standard chow (C) diet from weaning through pregnancy and lactation, and whether there are additive phenotypic effects of feeding the offspring an HF ..
  44. ncbi Translation elongation factor eEF1A2 is essential for post-weaning survival in mice
    H J Newbery
    Medical Genetics, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    J Biol Chem 282:28951-9. 2007
    ..We conclude that loss of eEF1A2 function is solely responsible for the abnormalities seen in these mice...
  45. ncbi Breastfeeding, introduction of complementary foods, and adiposity at 5 y of age
    Hillary L Burdette
    Division of Gastroenterology and Nutrition, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Clin Nutr 83:550-8. 2006
    ..Although dual-energy X-ray absorptiometry (DXA) is considered the most accurate measure of adiposity in children, it has rarely been used to examine the relation between infant feeding and adiposity during childhood...
  46. ncbi Determinants of early weaning and use of unmodified cow's milk in infants: a systematic review
    Katrien Wijndaele
    MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke s Hospital, Hills Rd, Cambridge, CB2 0QQ, United Kingdom
    J Am Diet Assoc 109:2017-28. 2009
    Introduction of complementary foods (weaning) before 4 to 6 months of age and unmodified cow's milk before age 12 months are associated with several health risks...
  47. ncbi The effect of abrupt weaning of suckler calves on the plasma concentrations of cortisol, catecholamines, leukocytes, acute-phase proteins and in vitro interferon-gamma production
    M C Hickey
    Teagasc, Grange Research Centre, Dunsany, Co Meath, Ireland
    J Anim Sci 81:2847-55. 2003
    The objective of this study was to examine the effect of abrupt weaning (inclusive of social group disruption and maternal separation) on the physiological mediators of stress and measures of immune function...
  48. ncbi Mobilization of PCBs from blubber to blood in northern elephant seals (Mirounga angustirostris) during the post-weaning fast
    Cathy Debier
    Unite de Biochimie de la Nutrition, Institut des Sciences de la Vie, Universite Catholique de Louvain, Croix du Sud 2 8, B 1348 Louvain la Neuve, Belgium
    Aquat Toxicol 80:149-57. 2006
    ..mobilization of polychlorinated biphenyls (PCBs) from the blubber of northern elephant seal pups during the post-weaning fast...
  49. ncbi Expression of Na+/glucose co-transporter 1 (SGLT1) is enhanced by supplementation of the diet of weaning piglets with artificial sweeteners
    Andrew W Moran
    Epithelial Function and Development Group, Department of Veterinary Preclinical Sciences, University of Liverpool, Liverpool, UK
    Br J Nutr 104:637-46. 2010
    ..A number of strategies have been proposed to overcome weaning problems. Artificial sweeteners, routinely included in piglets' diet, were thought to enhance feed palatability...
  50. ncbi Intestinal and peripheral immune response to MON810 maize ingestion in weaning and old mice
    Alberto Finamore
    Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Roma, Italy
    J Agric Food Chem 56:11533-9. 2008
    ..b>Weaning and old mice were fed a diet containing MON810 or its parental control maize or a pellet diet containing a GM-..
  51. ncbi Prevalence of and management factors contributing to Cryptosporidium sp. infection in pre-weaned and post-weaned calves in Johor, Malaysia
    Aida Muhid
    Downstream Industry Development Division, Department of Veterinary Services Malaysia, Lot 4G1, Presint 4, Wisma Tani, 62630 Putrajaya, Malaysia
    Exp Parasitol 127:534-8. 2011
    ....
  52. pmc Effects of early, abrupt weaning on HIV-free survival of children in Zambia
    Louise Kuhn
    Gertrude H Sergievsky Center and the Department of Epidemiology, Mailman School of Public Health, Columbia University, New York 10032, USA
    N Engl J Med 359:130-41. 2008
    ..We conducted a randomized trial to evaluate whether abrupt weaning at 4 months as compared with the standard practice has a net benefit for HIV-free survival of children.
  53. ncbi Stimulation of butyrate production in the large intestine of weaning piglets by dietary fructooligosaccharides and its influence on the histological variables of the large intestinal mucosa
    Takamitsu Tsukahara
    Laboratory of Animal Science, Kyoto Prefectural University, Shimogamo, Kyoto 606 8522, Japan
    J Nutr Sci Vitaminol (Tokyo) 49:414-21. 2003
    ..Six weaning piglets were used...
  54. ncbi Feeding practices and factors contributing to wasting, stunting, and iron-deficiency anaemia among 3-23-month old children in Kilosa district, rural Tanzania
    Peter S Mamiro
    Department of Food Technology and Nutrition, Faculty of Agriculture and Applied Biological Sciences, Gent University, Coupure Links 653, B 9000 Gent, Belgium
    J Health Popul Nutr 23:222-30. 2005
    ..There is an urgent need to improve tradi-tional complementary foods in the studied community in terms of energy density, amount of fat in the diet, and bioavailability of macro and micronutrients...
  55. ncbi Breastfeeding patterns in Rio Branco, Acre, Brazil: a survey of reasons for weaning
    Coral Wayland
    Department of Sociology and Anthropology, University of North Carolina, Charlotte, NC 28205, USA
    Cad Saude Publica 20:1757-61. 2004
    ..Finally, while women give a variety of responses for why breastfeeding was terminated, the most common answer (42.0%) was that the infant refused the breast. The meaning and implications of this response merit further investigation...
  56. ncbi Dietary supplementation with l-arginine partially counteracts serum metabonome induced by weaning stress in piglets
    Qinghua He
    Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China
    J Proteome Res 10:5214-21. 2011
    Arginine plays an important role in preventing intestinal dysfunction and metabolic disorders caused by early weaning stress. However, little is known about how arginine mitigates early weaning stress...
  57. ncbi Increasing weaning age improves pig performance in a multisite production system
    R G Main
    Food Animal Health and Management Center, Kansas State University, Manhattan 66506 0201, USA
    J Anim Sci 82:1499-507. 2004
    Two trials were conducted to determine the effects of weaning age on pig performance in a multisite production system. The second trial also evaluated the effects of modifying the nursery feeding program according to weaning age...
  58. ncbi Do early infant feeding practices vary by maternal ethnic group?
    Lucy J Griffiths
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Public Health Nutr 10:957-64. 2007
    ..To examine UK country and ethnic variations in infant feeding practices...
  59. ncbi Isotopic and dental evidence for infant and young child feeding practices in an imperial Roman skeletal sample
    Tracy L Prowse
    Department of Anthropology, Southern Illinois University Carbondale, Carbondale, IL 62901, USA
    Am J Phys Anthropol 137:294-308. 2008
    ..of bone collagen from 37 rib samples indicates that transitional feeding began by the end of the first year and weaning occurred by 2-2.5 years of age...
  60. ncbi Weaning behaviour in human evolution
    Louise T Humphrey
    Department of Paleontology, The Natural History Museum, Cromwell Road, London SW7 5BD, United Kingdom
    Semin Cell Dev Biol 21:453-61. 2010
    Human life history incorporates early weaning, a prolonged period of post-weaning dependency and slow somatic growth, late onset of female reproduction, reduced birth spacing and a significant post-reproductive female lifespan, combined ..
  61. ncbi Effects of feeding low protein diets to piglets on plasma urea nitrogen, faecal ammonia nitrogen, the incidence of diarrhoea and performance after weaning
    Jung Min Heo
    aSchool of Veterinary and Biomedical Sciences, Murdoch University, Australia
    Arch Anim Nutr 62:343-58. 2008
    This study evaluated the effects of feeding pigs low protein (LP) diets for different lengths of time after weaning on indices of protein fermentation, the incidence of postweaning diarrhoea (PWD), growth performance, and total-tract ..
  62. ncbi Effects of pair versus single housing on performance and behavior of dairy calves before and after weaning from milk
    A De Paula Vieira
    Animal Welfare Program, University of British Columbia, 2357 Main Mall, Vancouver, BC, V6T 1Z4, Canada
    J Dairy Sci 93:3079-85. 2010
    ..tested the effects of pair versus single housing on the performance and behavior of dairy calves before and after weaning. Twenty-seven Holstein calves were separated from the dam within 6h of birth, housed in individual pens for 4 d, ..
  63. ncbi Genetic and phenotypic relationships between carbohydrate larval antigen (CarLA) IgA, parasite resistance and productivity in serial samples taken from lambs after weaning
    R J Shaw
    AgResearch Limited, The Hopkirk Research Institute, Palmerston North 4442, New Zealand
    Int J Parasitol 43:661-7. 2013
    ..that testing for a carbohydrate larval antigen IgA response could be carried out at any time in the 5 months post-weaning. The transformed carbohydrate larval antigen IgA levels were genetically and phenotypically correlated negatively ..
  64. ncbi Acute, early thermal experience alters weaning onset in rats
    C J Gerrish
    Department of Psychology, Indiana University, Bloomington 47405, USA
    Physiol Behav 64:463-74. 1998
    We hypothesized that first ingestion of solid food (weaning onset) would be accelerated in young rats with advanced thermoregulatory development...
  65. ncbi Hormonal and dietary regulation of changes in bone density during lactation and after weaning in women
    H J Kalkwarf
    Division of General and Community Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Mammary Gland Biol Neoplasia 4:319-29. 1999
    ..Restoration of ovarian hormone production and decreased production of PTHrP2 are likely to result in the recovery of bone mineral after lactation has ceased...
  66. ncbi Maternal regulation of the hypothalamic-pituitary-adrenal axis in the 20-day-old rat: consequences of laboratory weaning
    M Schmidt
    Leiden Amsterdam Center for Drug Research Leiden University Medical Center, Leiden, The Netherlands
    J Neuroendocrinol 14:450-7. 2002
    ..Previous studies showed that, even at the time of weaning, maternal deprivation results in a dysregulation of the HPA axis at multiple levels...
  67. pmc Maternal environmental contribution to adult sensitivity and resistance to obesity in Long Evans rats
    Mariana Schroeder
    Psychology Department, Bar Ilan University, Ramat Gan, Israel
    PLoS ONE 5:e13825. 2010
    ..In the present study, we used a cross-fostering strategy to assess whether interactions with obese dams in the postnatal environment contributed to the development of obesity...
  68. ncbi Effect of feeding maternal colostrum or plasma-derived or colostrum-derived colostrum replacer on passive transfer of immunity, health, and performance of preweaning heifer calves
    D Priestley
    Department of Large Animal Clinical Sciences, University of Florida, Gainesville 32610, USA
    J Dairy Sci 96:3247-56. 2013
    ..8%), followed by CDCR (49%) and PDCR (28.6%). Calves fed MC had greater weaning weights and body weight gain than calves fed CR. Morbidity was lower for calves fed MC (46...
  69. ncbi Pre- and post-weaning piglet performance, sow food intake and change in backfat thickness in a group-housing system for lactating sows
    F Hultén
    Department of Obstetrics and Gynaecology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    Acta Vet Scand 38:119-33. 1997
    Four farms that group-housed sows from about 2 weeks of lactation until weaning (G-farms) and 3 farms, used as controls, that kept the sows individually penned throughout the 5 to 6-week-long lactation period (C-farms) were compared in ..
  70. ncbi Prevalence of virulence genes in Escherichia coli strains isolated from piglets in the suckling and weaning period in Mexico
    Andrea Toledo
    Departamento de Salud Publica, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
    J Med Microbiol 61:148-56. 2012
    Faecal Escherichia coli isolates from suckling (n = 503) and weaning (n = 450) piglets with and without diarrhoea from 10 farms in Mexico were examined for identification and prevalence of virulence genes. E...
  71. ncbi Infant feeding and weaning practices in Roman Egypt
    T L Dupras
    Department of Sociology and Anthropology, University of Central Florida, Orlando, FL 32816 1360, USA
    Am J Phys Anthropol 115:204-12. 2001
    Current knowledge of infant feeding and weaning practices during the Roman period in Egypt is limited to scanty documentary and iconographic evidence...
  72. ncbi Effect of pharmacological concentrations of zinc oxide with or without the inclusion of an antibacterial agent on nursery pig performance
    G M Hill
    Dept of Animal Sci, Michigan State Univ, East Lansing 48824 1225, USA
    J Anim Sci 79:934-41. 2001
    ..The results of these studies suggest that supplemental ZnO at 1,500 to 2,000 mg Zn/kg Zn improved postweaning pig performance, and its combination with an antibacterial agent resulted in additional performance improvements...
  73. pmc Minimising the stress of weaning of beef calves: a review
    Daniel Enríquez
    Laboratório de Etologia Aplicada e Bem Estar Animal, Departamento de Zootecnia e Desenvolvimento Rural, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
    Acta Vet Scand 53:28. 2011
    b>Weaning of beef calves is usually done abruptly and early compared to the natural weaning of the species, and is associated with simultaneous exposure of calves to a range of social and environmental stressors...
  74. pmc Elevations in mortality associated with weaning persist into the second year of life among uninfected children born to HIV-infected mothers
    Louise Kuhn
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, and Departments of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA
    Clin Infect Dis 50:437-44. 2010
    Early weaning has been recommended to reduce postnatal human immunodeficiency virus (HIV) transmission. We evaluated the safety of stopping breast-feeding at different ages for mortality of uninfected children born to HIV-infected mothers.
  75. ncbi Induction of gastric ornithine decarboxylase in early weaning rats
    C H Lin
    Department of Pediatrics, Wayne State University and Children s Hospital of Michigan, Detroit, Mich, USA
    Digestion 63:214-9. 2001
    Early weaning has been shown to induce intestinal ornithine decarboxylase (ODC) activities and cell proliferation in rats. No information is available about the effect of early weaning on ODC activity in the stomach.
  76. ncbi Blockade of dopamine D₃ but not D₂ receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment
    David J G Watson
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Int J Neuropsychopharmacol 15:471-84. 2012
    ..Three separate groups of male Lister hooded rats were group-housed or isolation-reared from weaning. Six weeks later rats received either vehicle or the dopamine D₃ selective antagonist, S33084 (0.04 and 0...
  77. ncbi Percutaneous endoscopic gastrostomy outcomes: can patient profiles predict mortality and weaning?
    V H Chong
    Gastroenterology Unit, Department of Medicine, Raja Isteri Pengiran Anak Saleha RIPAS Hospital, Negara Brunei Darussalam
    Singapore Med J 47:383-7. 2006
    ..Patient selection is important to identify those who will benefit from PEG. This study aims to identify patient factors that may help in patient selection for PEG...
  78. ncbi The Swiss iodized salt program provides adequate iodine for school children and pregnant women, but weaning infants not receiving iodine-containing complementary foods as well as their mothers are iodine deficient
    Maria Andersson
    Human Nutrition Laboratory, Institute of Food, Nutrition, and Health, Swiss Federal Institute of Technology Zurich, Schmelzbergstrasse 7, CH 8092 Zurich, Switzerland
    J Clin Endocrinol Metab 95:5217-24. 2010
    ..But weaning infants may be at risk of iodine deficiency because iodized salt contributes little dietary iodine during this ..
  79. ncbi Early weaning accelerates the differentiation of mucous neck cells in rat gastric mucosa: possible role of TGFalpha/EGFR
    Luciana H Osaki
    Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes 1524 ICB I 05508 900 São Paulo, SP, Brazil
    Differentiation 79:48-56. 2010
    The development of the gastric mucosa is controlled by hormones, growth factors and feeding behavior. Early weaning (EW), which means the abrupt interruption of suckling, increases proliferation and differentiation in the rat gastric ..
  80. ncbi Adults may be used to alleviate weaning stress in domestic foals (Equus caballus)
    Severine Henry
    Universite Rennes 1, UMR CNRS 6552, Laboratoire Ethologie Animale et Humaine, Rennes, Station Biologique, 35380 Paimpont, France
    Physiol Behav 106:428-38. 2012
    The present study aims to investigate whether the presence of unrelated adult horses at weaning would reduce the social stress of weaning and the emergence of undesirable behaviours...
  81. pmc Dietary n-6 PUFA deprivation for 15 weeks reduces arachidonic acid concentrations while increasing n-3 PUFA concentrations in organs of post-weaning male rats
    Miki Igarashi
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg 9, Room 1S126, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1791:132-9. 2009
    ..To do this, we fed post-weaning male rats a control n-6 and n-3 PUFA adequate diet and an n-6 deficient diet for 15 weeks, and measured stable ..
  82. ncbi Galacto-oligosaccharides are bifidogenic and safe at weaning: a double-blind randomized multicenter study
    Silvia Fanaro
    Neonatal Intensive Care Unit, University of Ferrara, Ferrara, Italy
    J Pediatr Gastroenterol Nutr 48:82-8. 2009
    ..Secondary objectives were the effects on stool characteristics, growth, and general well-being...
  83. pmc Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning
    Sarah J Borengasser
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
    PLoS ONE 6:e24068. 2011
    ..Mitochondrial dysfunction may be an underlying event that reduces hepatic fatty acid oxidation and precedes the development of detrimental obesity associated co-morbidities such as insulin resistance and NAFLD...
  84. ncbi Delayed introduction of solid feeding reduces child overweight and obesity at 10 years
    K A Seach
    Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia
    Int J Obes (Lond) 34:1475-9. 2010
    ....
  85. pmc Breastfeeding duration and perinatal cigarette smoking in a population-based cohort
    Jihong Liu
    Div of Reproductive Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Am J Public Health 96:309-14. 2006
    ..We examined the association between breastfeeding duration and maternal smoking before, during, and after pregnancy...
  86. ncbi Assessment and quantification of post-weaning multi-systemic wasting syndrome severity at farm level
    Pablo Alarcon
    Department of Veterinary Clinical Sciences, Royal Veterinary College, Hatfield AL9 7TA, United Kingdom
    Prev Vet Med 98:19-28. 2011
    Post-weaning multi-systemic wasting syndrome (PMWS) causes major economic losses for the English pig industry and severity of clinical signs and economic impact vary considerably between affected farms...
  87. ncbi Determinants of aflatoxin exposure in young children from Benin and Togo, West Africa: the critical role of weaning
    Y Y Gong
    Molecular Epidemiology Unit, Epidemiology and Health Services Research, School of Medicine, University of Leeds, Leeds, UK
    Int J Epidemiol 32:556-62. 2003
    ..Dietary exposure to high levels of the fungal toxin, aflatoxin, occurs in West Africa, where long-term crop storage facilitates fungal growth...
  88. ncbi Main intestinal markers associated with the changes in gut architecture and function in piglets after weaning
    Lucile Montagne
    Unité Mixte de Recherche Systèmes d Elevage, Nutrition Animale et Humanine, INRA Agrocampus Rennes, Saint Gilles, France
    Br J Nutr 97:45-57. 2007
    ..of events concerning the morphology, physiology and ecology of the gut of piglets during the 2 weeks following weaning, in order to provide a limited number of variables that could be relevant markers of the gut post-weaning changes...
  89. ncbi Changes in abundance of Lactobacillus spp. and Streptococcus suis in the stomach, jejunum and ileum of piglets after weaning
    Yong Su
    Laboratory of Gastrointestinal Microbiology, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China
    FEMS Microbiol Ecol 66:546-55. 2008
    ..suis populations as potentially beneficial and harmful groups, in the stomach, jejunum and ileum of piglets after weaning (21 days postpartum) by 16S rRNA gene-based methods...
  90. pmc Post-weaning maternal effects and the evolution of female dominance in the spotted hyena
    Heather E Watts
    Department of Zoology, Michigan State University, East Lansing, MI 48824, USA
    Proc Biol Sci 276:2291-8. 2009
    ..aggressiveness in females as a compensatory mechanism for mothers to secure food access for their young after weaning. Our analyses yielded results consistent with this hypothesis...
  91. pmc The meaning of weaning: influence of the weaning period on behavioral development in mice
    James P Curley
    Department of Psychology, Columbia University, New York, N Y 10027, USA
    Dev Neurosci 31:318-31. 2009
    ..Females who were themselves weaned earlier also appeared to wean their own pups earlier. Sex-specific effects of weaning age were found on levels of oxytocin and vasopressin V1a receptor density in the hypothalamus, central nucleus of ..
  92. ncbi A descriptive study investigating the use and nature of baby-led weaning in a UK sample of mothers
    Amy Brown
    Department of Psychology, School of Human Sciences, Swansea University, Swansea, UK
    Matern Child Nutr 7:34-47. 2011
    An alternative to traditional weaning methods known as baby-led weaning (BLW) appears to be emerging in the UK...
  93. ncbi Supplemental vitamin C and yeast cell wall beta-glucan as growth enhancers in newborn pigs and as immunomodulators after an endotoxin challenge after weaning
    S D Eicher
    Livestock Behavior Research Unit, USDA ARS, West Lafayette, IN 47907, USA
    J Anim Sci 84:2352-60. 2006
    ..Supplements were given in whole milk within 36 h of birth and then daily for 2 wk until weaning, when the supplement was given in feed for an additional 2 wk...
  94. pmc Characterisation of physiological and immunological responses in beef cows to abrupt weaning and subsequent housing
    Eilish M Lynch
    Animal and Bioscience Department, Animal and Grassland Research and Innovation Centre, Teagasc, Grange, Dunsany, Co Meath, Ireland
    BMC Vet Res 6:37. 2010
    b>Weaning involves the permanent separation of the calf from the dam and has been shown to be stressful for both...
  95. ncbi Effect of a high-protein diet on food intake and liver metabolism during pregnancy, lactation and after weaning in mice
    Björn Kuhla
    Research Unit Nutritional Physiology Oskar Kellner, Leibniz Institute for Farm Animal Biology FBN, Dummerstorf, Germany
    Proteomics 10:2573-88. 2010
    ..these molecular events, mice were fed a high-protein (HP) diet from pregnancy, during lactation until after weaning and compared with control fed counterparts...
  96. ncbi Fenceline contact of beef calves with their dams at weaning reduces the negative effects of separation on behavior and growth rate
    E O Price
    Department of Animal Science, University of California, Davis 95616, USA
    J Anim Sci 81:116-21. 2003
    The purpose of this study was to examine the hypothesis that fenceline contact between beef calves and cows at weaning reduces indices of behavioral distress and associated temporary reductions in weight gain...
  97. ncbi Differential development of stress system (re)activity at weaning dependent on time of disruption of maternal care
    L Enthoven
    Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Leiden University Medical Center, Leiden University, PO Box 9502, RA Leiden, The Netherlands
    Brain Res 1217:62-9. 2008
    ..male CD1 mice whether the postnatal day (pnd) of deprivation determines the (re)activity of the stress system at weaning under basal and novelty stress conditions...
  98. pmc Maternal smoking and the risk of early weaning: a meta-analysis
    B L Horta
    Department of Social Medicine, School of Medicine and Psychology, Universidade Catolica de Pelotas, Pelotas, Brazil
    Am J Public Health 91:304-7. 2001
    This study reviewed evidence on the effect of maternal smoking on early weaning.
  99. ncbi Impaired arsenic metabolism in children during weaning
    Britta Fängström
    Institute of Environmental Medicine, Karolinska Institutet, Box 210, 17177 Stockholm, Sweden
    Toxicol Appl Pharmacol 239:208-14. 2009
    ..Methylation of inorganic arsenic (iAs) via one-carbon metabolism is a susceptibility factor for a range of arsenic-related health effects, but there is no data on the importance of arsenic metabolism for effects on child development...
  100. ncbi From the ape's dilemma to the weanling's dilemma: early weaning and its evolutionary context
    G E Kennedy
    Department of Anthropology, University of Calfornia, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90024, USA
    J Hum Evol 48:123-45. 2005
    ..5 years. Assuming that living great apes demonstrate the ancestral weaning pattern, modern humans display a derived pattern that requires explanation, particularly since earlier weaning ..
  101. ncbi Early postnatal leptin blockage leads to a long-term leptin resistance and susceptibility to diet-induced obesity in rats
    L Attig
    UMR 1197 INRA Université Paris Sud, Orsay, France
    Int J Obes (Lond) 32:1153-60. 2008
    ..Using a recombinant rat leptin antagonist, we investigated the effects of early postnatal leptin disruption on long-term leptin sensitivity and metabolic phenotype...

Research Grants74

  1. INTERVENTIONS TO PROMOTE VENTILATOR WEANING
    Kathleen Stone; Fiscal Year: 2002
    DESCRIPTION (As Adapted from the Investigator's Abstract): Weaning the critically ill patient from mechanical ventilation (MV) to spontaneous ventilation (SpV) continues to be a significant challenge for nursing...
  2. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..These animals develop heart failure shortly after weaning, on the basis of unregulated autophagy, thereby defining an essential role for insulin and IGF-1 signaling acting ..
  3. Effects of In Utero and Transgenerational Exposure of Avy Mice to Bisphenol A
    CHERYL SUSAN ROSENFELD; Fiscal Year: 2010
    ..Control a/a females will be maintained on the AIN-93G diet. Pre- and post-weaning behavioral assessments will be performed on the pups to determine whether BPA affects their anxiety levels, ..
  4. Effect of Perinatal Diet on Developmental Programming of the Skeleton
    Mary L Bouxsein; Fiscal Year: 2010
    ..g., prenatal CR weaned to postnatal HF). Mice will be sacrificed at weaning (3 wks of age), adolescence (6 wks of age), young adulthood (12 wks of age) or older adulthood (20 wks of age)...
  5. Interaction of fetal growth and bisphenol A in obesity
    Frederick S vom Saal; Fiscal Year: 2013
    ..in body weight, while macrosomic males only experience a 30% increase in body weight, during the first week after weaning, after which IUGR and macrosomic males remain significantly heavier than males with a median body weight at birth...
  6. Developmental Origins of Phenotypic Characteristics that Predict Longevity
    Andrzej Bartke; Fiscal Year: 2012
    ..from hormonal replacement therapy in long-lived mutants, we propose that the period of rapid pre- and post-weaning growth may represent a critical "time window" for the effects of early hormonal milieu on healthspan and lifespan...
  7. GI-Safer Formulation of Indomethacin for use in Preterm Neonates
    UPENDRA K MARATHI; Fiscal Year: 2013
    ..experiments, we found that there was an apparent resistance to GI toxicity of indomethacin in rat neonates before weaning if the animals were breast- fed, but not if they were formula-fed...
  8. Maternal Hyperinsulinemia and Fetal Programming
    Mulchand S Patel; Fiscal Year: 2011
    ..and dietary supplementation with 1-lipoic acid will be enforced in the 1-HC female rats from the time of weaning and consequences for both the mother and the progeny will be monitored...
  9. Epigenetic programming of brain development by choline nutrition
    Jan Krzysztof Blusztajn; Fiscal Year: 2011
    ..diets containing choline-deficient, choline-sufficient, or choline-supplemented diets throughout pregnancy until weaning. The results of the investigations will provide information on epigenetic processes that are associated with the ..
  10. Lactation and Incidence of Diabetes Mellitus in CARDIA Women
    ERICA PAULINE GUNDERSON; Fiscal Year: 2013
    ..provided by applicant): Lactation has favorable effects on cardiometabolic risk factor levels that persist after weaning, and may prevent the onset of type 2 diabetes mellitus (DM) in women in mid to late life...
  11. Myosin 15:Genetics, Pathology and Therapeutic Potential
    Sally A Camper; Fiscal Year: 2013
    ..vectors for gene therapy and a database of genes exhibiting differential expression in the cochlea between weaning and adulthood in normal and Myo15 mutant mice. These studies laid a sound foundation for the goals of this grant...
  12. Identifying a role for commensal bacteria on the liver immune priming environment
    Jean Publicover; Fiscal Year: 2013
    ..It is known that upon weaning, the commensal bacteria in the intestines changes dramatically in both young mice and infants...
  13. Neural control of adaptive Beta-cell growth in insulin resistant rats
    WILLIAM CHARLES DIAZ; Fiscal Year: 2011
    ..Prior to weaning, both ZF and ZLC animals have the same BCM, glucose and insulin levels...
  14. Factors Associated with Ventilator-Associated Pneumonia Guideline Adherence
    Hiroko Kiyoshi-Teo; Fiscal Year: 2011
    ..VAP strategies: hand hygiene, oral hygiene, semi-recumbent patient positioning, subglottic suctioning, early weaning from mechanical ventilation, and maintenance of a ventilator circuit...
  15. Testing the feasibility of patient-controlled sedation in ventilated ICU patients
    Craig R Weinert; Fiscal Year: 2013
    ..While sedation is indicated at times, it can have serious side effects, including delayed weaning, mental status changes, prolonged MV, and extended ICU stay...
  16. Mechanisms of Early Life Stress-Induced Endothelial Dysfunction
    Dao Ho; Fiscal Year: 2013
    ..Maternal separation with early weaning (MSEW), a chronic behavioral stress model of ELS, consisted of separating litters from the dams for 4 hours/day ..
  17. A novel treatment, TAT-HSP70, in attenuating lung injury in sepsis induced ARDS
    MARY MELANIE LYONS; Fiscal Year: 2012
    ..including sepsis, ARDS, sickness behavior, CIP, decreased locomotor activity, and difficulty in ventilator weaning. Sepsis causes dysfunction in a number of different types of cells, including pulmonary epithelial cells...
  18. Conditional Isolation of Fgf23 Activity
    Kenneth E White; Fiscal Year: 2011
    ..KL), however there are several limitations, including that the Fgf23 global knock-out is severely compromised at weaning and dies at 8-10 weeks, and the transgenic mice uncontrollably over-express FGF23...
  19. Mechanisms of diaphragm muscle dysfunction in critical-illness myopathy
    CATHERINE S SASSOON; Fiscal Year: 2012
    ..These patients have difficulty weaning from mechanical ventilation...
  20. Maternal methyl diet and epigenetic imprint in offspring mammary carcinogenesis
    CHUNG SUN PARK; Fiscal Year: 2012
    ..Pregnant rats will be assigned to either the control or lipotrope-supplemented diet. At weaning, mammary tissues from dams will be collected to examine DNA methylation and gene expression...
  21. The Common Marmoset as a Primate Model of Maternal Obesity
    SUZETTE D contact TARDIF; Fiscal Year: 2010
    ..3. To characterize changes in body composition, feeding and metabolism from post-weaning infancy (6 months) to adulthood (24 months of age) in offspring of these pregnancies by: tracking growth ..
  22. Regulation of mammary gland biology by RLIM/Rnf12 and the paternal X chromosome
    INGOLF M BACH; Fiscal Year: 2013
    ..Aim 1 will establish RLIM as triggering weaning-induced alveolar cell death/involution and test the involvement of the UPS system...
  23. PERINATAL METABOLIC AND HORMONAL EFFECTS
    Sherin U Devaskar; Fiscal Year: 2010
    ..we will use the rat model subjected to pre- and postnatal calorie restriction and fed a hypercaloric diet post-weaning. The specific aims consist of exploring the impact of pre- and post-natal nutrient restriction on male and female ..
  24. Prognostic &Therapeutic Implications of Breathing Patterns in Acute Lung Injury
    FRANK JOSEPH JACONO; Fiscal Year: 2013
    ..variable ventilation (BVV) to limit changes in breathing patterns, minimize VALI and improve ventilator weaning. In the present application we propose pre- clinical studies in well-validated animal models...
  25. Hepcidin therapy for iron overload and hematologic disorders
    Stefano Rivella; Fiscal Year: 2013
    ..a. Can minihepcidins started after weaning prevent the development of iron overload in mouse models of severe (hepcidin knockout) or moderate (HFE knockout) ..
  26. Lactation and Glucose Tolerance After GDM Pregnancy
    ERICA PAULINE GUNDERSON; Fiscal Year: 2011
    Lactation has immediate favorable effects on glucose tolerance that may persist after weaning to prevent development of type 2 diabetes mellitus (DM) in women...
  27. Role of Gender-associated Microbiota in Organ-specific Autoimmunity
    Martin A Kriegel; Fiscal Year: 2013
    ..candidate microbiota for possible gender differences in young adult NOD mice and at multiple time points from weaning age until development of disease...
  28. Preclinical Therapy and Novel Mechanisms in Ventilator-induced Diaphragm Atrophy
    Joseph B Shrager; Fiscal Year: 2013
    ..This diaphragm dysfunction appears to be an important cause of the difficulty often encountered weaning patients from mechanical ventilation (MV);it is thus the basis for subsequent ventilator-associated complications ..
  29. Does breast cancer start in the womb? BPA, mammogenesis and neoplasia
    ANA SOTO; Fiscal Year: 2010
    ..Two windows of susceptibility will be examined: from gestational day (GD) 9 to birth, and from GD9 to weaning (postnatal day [PND21])...
  30. Epigenetic Consequences of Prenatal Alcohol Exposure
    Eva E Redei; Fiscal Year: 2013
    ..dietary supplement regimes, known to affect epigenetic mechanisms, to animals during lactation, or post- weaning, and subsequently screen for improvement in spatial learning and memory as well as gene expression patterns and ..
  31. Mechanical ventilation, oxidative stress, and diaphragmatic atrophy
    Scott K Powers; Fiscal Year: 2012
    ..g., patients in respiratory failure). The removal of patients from MV is termed "weaning" and problems in weaning are extremely common...
  32. Entrainment-based mechanical ventilation
    Chi Sang Poon; Fiscal Year: 2010
    ..life support procedure that is integral to any intensive care unit, emergency room, ambulatory unit or ventilator weaning facility, and is ubiquitous in many medical units and rehabilitation or long-term care facilities, including the ..
  33. Global Network for Women's and Children's Health
    Edward A Liechty; Fiscal Year: 2012
    ..3.) Zinc supplementation beginning at partial weaning will lead to a further decrease in the incidence of diarrhea in these infants. 4...
  34. Vulnerability to Drug Abuse and Treatment Efficacy: Animal Models
    Marilyn E Carroll; Fiscal Year: 2010
    ..Self-administration of COC and METH will be compared before, during, and after pregnancy and weaning to determine whether elevated levels of drug self-administration decrease when progesterone is elevated...
  35. Role of Fetal Lung Macrophages in Bronchopulmonary Dysplasia
    Lawrence S Prince; Fiscal Year: 2013
    ..marked increase in neutrophilic lung inflammation following subsequent intratracheal LPS treatment of pups after weaning. Therefore, structural abnormalities in the lungs resulting from prenatal inflammation may define a vulnerable ..
  36. Assessing feeding practices, immune activation, and HIV risk in African infants
    HEATHER BERYL JASPAN; Fiscal Year: 2013
    ..In addition, a study of EBF with rapid weaning at four months showed high morbidity in the uninfected infants...
  37. Early Dietary Intervention and Later Signs of Beta-Cell Autoimmunity: Potential M
    Mikael Knip; Fiscal Year: 2012
    ..The mothers will be encouraged to exclusively breast-feed their infants as long as possible. The timing of weaning and introduction of study formula will be left to the mother...
  38. Developmental Origins of Decreased Resilience
    Rodney W Johnson; Fiscal Year: 2013
    ..aged 6-months to 3-years and to represent the stressful transition from the farrowing environment to the post weaning nursery...
  39. Neuroinflammation and developmental vulnerability to manganese toxicity
    Ronald B Tjalkens; Fiscal Year: 2013
    ..mice and astrocyte-specific NF-kB knockout mice generated in our laboratory that expose animals to Mn from pre-weaning through puberty and then examine their susceptibility to the dopaminergic neurotoxicant, 1-methyl-4-phenyl-1,2,3,..
  40. MODEL FOR SENSITIVE PERIODS IN EARLY FLAVOR LEARNING
    JULIA ANNE MENNELLA; Fiscal Year: 2013
    ..liking of these foods, and the likelihood that mothers will feed these foods to their children after weaning. Based on solid, previous research in humans and other animals, the over-arching goals of the proposed research ..
  41. Mechanisms of lens growth regulation
    Xiaohua Gong; Fiscal Year: 2013
    ..Mutant lenses display drastically reduced growth after weaning age and stop growing at the age of 8 weeks...
  42. Independent Scientist Development Award in Oxidative Stress and Apnea
    Rudy M Ortiz; Fiscal Year: 2013
    ..In turn, they provide extended mentorship and research direction to help insure my weaning to full research independence...
  43. Longevity genes and calorie restriction: early post-natal effects
    Andrzej Bartke; Fiscal Year: 2013
    ..impact of modestly reducing the amount of available nutrients during suckling (or suckling and the immediate post-weaning period) in normal mice, and the effects of early (starting at one or two weeks) as compared to late (starting at ..
  44. Experimental evolution recapitulating adaptation after horizontal gene transfer
    JOSHUA KIERAN MICHENER; Fiscal Year: 2013
    ..Different selection strategies, such as pre-adaptation to a source of stress like pH or gradual weaning on the challenging substrate DCM, will be compared...
  45. THERAPEUTIC MOTOR TRAINING AND FETAL ALCOHOL EFFECTS
    William T Greenough; Fiscal Year: 2010
    ..We have found that the capacity for post-weaning cytogenesis in adolescence and young adulthood is present, even enhanced, in the motor cortex of rats given binge-..
  46. Neurobehavioral Impacts of Early Mn Exposures
    Donald R Smith; Fiscal Year: 2013
    ..or underlying neurochemical alterations. Aim 1 will determine whether pre-weaning or continuous postnatal Mn exposure produces neurobehavioral deficits in young adults, using a rodent model of Mn ..
  47. Tippy a novel mouse model for human ataxia epilepsy
    KATHLEEN JOYCE contact MILLEN; Fiscal Year: 2010
    ..Homozygous tippy mutants exhibit ataxia and epilepsy and do not survive past weaning ages...
  48. Interactions between neuronal networks that regulate food intake and body weight
    Lori M Zeltser; Fiscal Year: 2013
    ..in young LeprHYP mice would be defended in adults, LeprHYP mice were pair-fed to the intake of controls from weaning through 10 weeks of age...
  49. Randomonized controlled trial-lactoferrin prevention of diarrhea in children
    THOMAS GEORGE CLEARY; Fiscal Year: 2010
    ..that are important for protecting the breast fed infant might be expected to decrease the adverse effects of weaning on diarrhea, growth, and development...
  50. Mechanisms of exercise protection in ventilator-induced diaphragm dysfunction
    Scott K Powers; Fiscal Year: 2013
    ..Although MV is often a life- saving intervention, prolonged MV gives rise to problems in "weaning" patients from the ventilator...
  51. DEVELOPMENTAL MODELS OF GATING DEFICITS IN SCHIZOPHRENIA
    Mark A Geyer; Fiscal Year: 2010
    ..Isolation rearing of rats and mice from weaning is a non-pharmacological manipulation that leads to deficits in prepulse inhibition of startle...
  52. Protective role of creb-binding protein in maturation and aging
    Charles V Mobbs; Fiscal Year: 2011
    ..I. Causes and consequences of decline in CBP-HAT activity during maturation. Specific lipids after weaning reduce the rapid reduction of CBP during maturation...
  53. The Role of Adenosine Receptors in Th Cell Development and Function
    Peter B Ernst; Fiscal Year: 2013
    ..However, few studies have examined the development of tolerance to luminal microbiota during the post-weaning period but the responses during this time may affect the risk of developing IBD later in life...
  54. Phase 2 Study of Belatacept, Alemtuzumab, and Sirolimus in Renal Transplantation
    Allan D Kirk; Fiscal Year: 2013
    ..In Specific Aim 3, a strategy will be evaluated for immune management that predicates drug weaning on objective measures of homeostatic repopulation including flow cytometric assessment of Ki67...
  55. Developmental Programming by Mismatch of Pre-and Postnatal Nurtition
    Mark J Nijland; Fiscal Year: 2011
    ..After birth, MNR mothers are fed ad lib either chow or HED. After weaning all OFF eat chow...
  56. A nonhuman primate model for the link between childhood asthma and obesity
    Eliot R Spindel; Fiscal Year: 2010
    ..Furthermore, we will determine if switching HF diet offspring to a control diet after weaning can reverse the pulmonary changes...
  57. Attenuating Inflammation via Protein-Calorie Restriction
    Todd W Rice; Fiscal Year: 2010
    ..Differences in clinical outcomes, including weaning patients from the ventilator, will be assessed. Through collaboration with his clinical mentor, Dr. Arthur P...
  58. The Multimodal Rehabilitation of Older Ventilated Survivors Of Critical Illness
    Avelino Catalino Verceles; Fiscal Year: 2013
    ..in our MRP will translate into clinically meaningful outcomes, including increased ambulatory capacity, respiratory muscle strength, improved quality of life and better rates of weaning from mechanical ventilation.
  59. REPRODUCTIVE ASSESSMENTS BY CONTINUOIUS BREEDING (RACB)
    Rochelle W Tyl; Fiscal Year: 2009
    ..disrupting chemicals;antiretroviral agents;infertility;pregnancy loss;birth defects;dosing pre-weaning mouse pups;rats;mice...
  60. REPRODUCTIVE ASSESSMENTS BY CONTINUOIUS BREEDING (RACB)
    Rochelle Tyl; Fiscal Year: 2013
    ..disrupting chemicals;antiretroviral agents;infertility;pregnancy loss;birth defects;dosing pre-weaning mouse pups;rats;mice...
  61. Causal inference in infectious disease prevention studies
    Michael G Hudgens; Fiscal Year: 2013
    ..is motivated by studies to prevent postnatal mother-to-child transmission (MTCT) of HIV where HIV-free death and weaning are competing risks...
  62. Ventilator-induced diaphragmatic atrophy: role of FoxO signaling
    Scott K Powers; Fiscal Year: 2013
    ..Although MV is often a life-saving intervention, prolonged MV promotes problems in "weaning" patients from the ventilator...
  63. Testing Therapies in a New Mild SMA Mouse: A Model for Type II/III Patients
    Cathleen M Lutz; Fiscal Year: 2013
    ..that it allows us to begin testing the effects of increasing SMN at later postnatal time points, even well past weaning. By incorporating a conditional inversion allele at the Smn1 locus we can transform the Burgheron model described ..
  64. Omega-3 fat to reduce risk for breast cancer
    WANDA ELAINE HARDMAN; Fiscal Year: 2010
    ..At weaning, female offspring will be randomized to the two diets and followed for mammary cancer development...
  65. Endocrine Status of MG Stroma Alters Breast CA Invasion
    Pepper Schedin; Fiscal Year: 2004
    ..During parturition or weaning-induced mammary gland involution, mammary stroma is degraded and stroma levels of matrix metalloproteinases (MMP) ..
  66. CNS DEVELOPMENT UNDER HYPERGRAVITY : MODULATION BY TH?
    ELIZABETH SAJDEL SULKOWSKA; Fiscal Year: 2004
    ..Based on preliminary findings suggesting that exposure to centrifugation from gestation through weaning results in changes in the developing cerebellum and altered thyroid status in rat neonates, we predict that: (1) ..
  67. Risk Factors for Late Life Anxiety
    JOHN CALAMARI; Fiscal Year: 2006
    ..In preliminary study 2, specific negative affect (NA) traits predicted coping with the rigors of ventilator weaning and early weaning success...
  68. MAINTENANCE OF A RODENT BREEDING AND HOLDING FACILITY
    RONALD SCHUELER; Fiscal Year: 1993
    Maintain and provide for the care and breeding of genetically defined rabbits (approximately 600 past the age of weaning). House rabbits in cage meeting Government requirements and provided by the Government...
  69. MECHANICAL VENTILATION AND RESPIRATORY MUSCLES
    Scott Powers; Fiscal Year: 2004
    ..Unfortunately, the withdrawal of MV, or weaning, can be difficult in a large number of cases...
  70. TGF B1'S ROLE IN PRIMARY AND REPARATIVE DENTINOGENESIS
    RENA D SOUZA; Fiscal Year: 2001
    ..TGF-beta 1(-/-) mice die at weaning from widespread inflammation due to the loss of a critical regulator of immune function...
  71. Feasibility Study of Probiotics for Growth Faltering
    Christine Wanke; Fiscal Year: 2006
    Diarrheal disease and growth faltering that occur at the time of weaning are significant public health problems...
  72. PREMATURE WEANING AND ADULT CHOLESTEROL HOMEOSTASIS
    DONALD MC NAMARA; Fiscal Year: 1993
    The proposed studies will investigate the effect of premature weaning on the regulation of cholesterol and lipoprotein metabolism in the adult guinea pig...
  73. REGULATION OF GENE EXPRESSION IN THE SMALL INTESTINE
    Jeffrey Gordon; Fiscal Year: 2005
    ..Moreover, changes normally associated with the suckling-weaning transition are elicited in adult germ-free mice by B...
  74. RESPIRATORY PUMP FAILURE--APPLIED PHYSIOLOGY
    Rolf Hubmayr; Fiscal Year: 1992
    The ultimate goal of this proposal is to test the following hypotheses: a) hypercarbic respiratory failure during weaning from mechanical ventilation usually results from diaphragm fatigue, and b) diaphragm fatigue results from an ..