regenerative medicine

Summary

Summary: A field of medicine concerned with developing and using strategies aimed at repair or replacement of damaged, diseased, or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.

Top Publications

  1. ncbi In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    Qiao Zhou
    Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 455:627-32. 2008
  2. ncbi Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
    Arnold I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
    J Cell Physiol 213:341-7. 2007
  3. ncbi Concise review: Adipose-derived stem cells as a novel tool for future regenerative medicine
    Hiroshi Mizuno
    Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, Tokyo, Japan
    Stem Cells 30:804-10. 2012
  4. ncbi Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies?
    M Z Ratajczak
    Stem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 26:1166-73. 2012
  5. ncbi Tissue engineering and regenerative medicine -where do we stand?
    Raymund E Horch
    Department of Plastic and Hand Surgery and Laboratory for Tissue Engineering and Regenerative Medicine, Friedrich Alexander University Erlangen Nuernberg, Erlangen, Germany
    J Cell Mol Med 16:1157-65. 2012
  6. ncbi The potential of adipose stem cells in regenerative medicine
    Bettina Lindroos
    Regea Institute for Regenerative Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland
    Stem Cell Rev 7:269-91. 2011
  7. ncbi Induced pluripotent stem cells: current progress and potential for regenerative medicine
    Giovanni Amabile
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Trends Mol Med 15:59-68. 2009
  8. pmc Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine
    Paul S Knoepfler
    Department of Cell Biology and Human Anatomy and Stem Cell Program, University of California Davis School of Medicine, Sacramento, CA, USA
    Stem Cells 27:1050-6. 2009
  9. pmc Reprogramming cellular identity for regenerative medicine
    Anne B C Cherry
    Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 148:1110-22. 2012
  10. pmc Stem cell heterogeneity: implications for aging and regenerative medicine
    Christa E Muller-Sieburg
    Sanford Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 119:3900-7. 2012

Detail Information

Publications357 found, 100 shown here

  1. ncbi In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    Qiao Zhou
    Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 455:627-32. 2008
    One goal of regenerative medicine is to instructively convert adult cells into other cell types for tissue repair and regeneration...
  2. ncbi Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
    Arnold I Caplan
    Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA
    J Cell Physiol 213:341-7. 2007
    ..This review summarizes the biological basis for the in vivo functioning of MSCs through development and aging...
  3. ncbi Concise review: Adipose-derived stem cells as a novel tool for future regenerative medicine
    Hiroshi Mizuno
    Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, Tokyo, Japan
    Stem Cells 30:804-10. 2012
    ..Mesenchymal stem cells seem to be an ideal population of stem cells for practical regenerative medicine, because they are not subjected to the same restrictions...
  4. ncbi Pivotal role of paracrine effects in stem cell therapies in regenerative medicine: can we translate stem cell-secreted paracrine factors and microvesicles into better therapeutic strategies?
    M Z Ratajczak
    Stem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 26:1166-73. 2012
    Although regenerative medicine is searching for pluripotent stem cells that could be employed for therapy, various types of more differentiated adult stem and progenitor cells are in meantime being employed in clinical trials to ..
  5. ncbi Tissue engineering and regenerative medicine -where do we stand?
    Raymund E Horch
    Department of Plastic and Hand Surgery and Laboratory for Tissue Engineering and Regenerative Medicine, Friedrich Alexander University Erlangen Nuernberg, Erlangen, Germany
    J Cell Mol Med 16:1157-65. 2012
    Tissue Engineering (TE) in the context of Regenerative Medicine (RM) has been hailed for many years as one of the most important topics in medicine in the twenty-first century...
  6. ncbi The potential of adipose stem cells in regenerative medicine
    Bettina Lindroos
    Regea Institute for Regenerative Medicine, University of Tampere and Tampere University Hospital, Tampere, Finland
    Stem Cell Rev 7:269-91. 2011
    ..In this review, some of the aspects of examination on ASCs in vitro and the utilization of ASCs in clinical studies are discussed...
  7. ncbi Induced pluripotent stem cells: current progress and potential for regenerative medicine
    Giovanni Amabile
    Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
    Trends Mol Med 15:59-68. 2009
    ..The approach of generating patient-specific pluripotent cells will undoubtedly transform regenerative medicine in many ways.
  8. pmc Deconstructing stem cell tumorigenicity: a roadmap to safe regenerative medicine
    Paul S Knoepfler
    Department of Cell Biology and Human Anatomy and Stem Cell Program, University of California Davis School of Medicine, Sacramento, CA, USA
    Stem Cells 27:1050-6. 2009
    ..serious as stem cell tumorigenicity represents the key obstacle to the safe use of stem cell-based regenerative medicine therapies...
  9. pmc Reprogramming cellular identity for regenerative medicine
    Anne B C Cherry
    Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 148:1110-22. 2012
    ....
  10. pmc Stem cell heterogeneity: implications for aging and regenerative medicine
    Christa E Muller-Sieburg
    Sanford Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 119:3900-7. 2012
    ..This finding has implications for other aspects of HSC biology and applications in re-generative medicine. The possibility that other adult tissue stem cells show similar heterogeneity and mechanisms of aging is discussed...
  11. ncbi The stem cell niche in regenerative medicine
    Amy J Wagers
    Howard Hughes Medical Institute, Cambridge, MA, USA
    Cell Stem Cell 10:362-9. 2012
    ..This Perspective will discuss how the niche influences stem cells in homeostasis, in the progression of degenerative and malignant diseases, and in therapeutic strategies for tissue repair...
  12. ncbi Very small embryonic-like stem cells with maximum regenerative potential get discarded during cord blood banking and bone marrow processing for autologous stem cell therapy
    Deepa Bhartiya
    Stem Cell Biology Department, National Institute for Research in Reproductive Health, Parel, Mumbai, India
    Stem Cells Dev 21:1-6. 2012
    ....
  13. pmc Directed differentiation of human-induced pluripotent stem cells generates active motor neurons
    Saravanan Karumbayaram
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Stem Cells 27:806-11. 2009
    ..These findings demonstrate the feasibility of using iPS-derived motor neuron progenitors and motor neurons in regenerative medicine applications and in vitro modeling of motor neuron diseases.
  14. ncbi Adipose tissue derived stem cells secretome: soluble factors and their roles in regenerative medicine
    António J Braga Osório Gomes Salgado
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    Curr Stem Cell Res Ther 5:103-10. 2010
    ..Similar to other stem cell populations, it was initially thought that the main potential of ASCs for regenerative medicine approaches was intimately related to their differentiation capability...
  15. ncbi Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration
    Chris Jopling
    Center of Regenerative Medicine in Barcelona, Dr Aiguader, 88, 08003 Barcelona, Spain
    Nat Rev Mol Cell Biol 12:79-89. 2011
    The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can potentially be accomplished using the processes of dedifferentiation, transdifferentiation or reprogramming...
  16. pmc Concise review: adipose-derived stromal cells for skeletal regenerative medicine
    Benjamin Levi
    Hagey Pediatric Regenerative Medicine Research Laboratory, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine, Stanford, California 94305 5148, USA
    Stem Cells 29:576-82. 2011
    ....
  17. ncbi Mesenchymal stem cell: keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine
    Paul S Frenette
    Ruth L and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Annu Rev Immunol 31:285-316. 2013
    ..We review their role and that of other putative niche constituents in the regulation of bone marrow HSCs. Additionally, how MSCs and their stromal progeny alter immune function is discussed, as well as potential therapeutic implications...
  18. ncbi Tissue engineering and regenerative medicine: history, progress, and challenges
    Francois Berthiaume
    Department of Biomedical Engineering, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Annu Rev Chem Biomol Eng 2:403-30. 2011
    The past three decades have seen the emergence of an endeavor called tissue engineering and regenerative medicine in which scientists, engineers, and physicians apply tools from a variety of fields to construct biological substitutes ..
  19. ncbi Extreme makeover: converting one cell into another
    Qiao Zhou
    Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, HHMI, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Cell Stem Cell 3:382-8. 2008
    ..Alternatively, adult cells may be directly converted into other mature cells or progenitors. We discuss and compare these two approaches with particular emphasis on the latter and its relevance for regenerative medicine.
  20. pmc Harnessing the potential of induced pluripotent stem cells for regenerative medicine
    Sean M Wu
    Cardiovascular Research Center, Division of Cardiology, Massachusetts General Hospital, Boston 02114, Massachusetts, USA
    Nat Cell Biol 13:497-505. 2011
    ..We believe that a better understanding of the molecular basis of pluripotency, cellular reprogramming and lineage-specific differentiation of iPSCs is necessary for progress in regenerative medicine.
  21. ncbi Turning straw into gold: directing cell fate for regenerative medicine
    Dena E Cohen
    Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Rev Genet 12:243-52. 2011
    b>Regenerative medicine offers the hope that cells for disease research and therapy might be created from readily available sources. To fulfil this promise, the cells available need to be converted into the desired cell types...
  22. ncbi Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine
    Cristi L Stoick-Cooper
    Department of Pharmacology, Howard Hughes Medical Institute, and Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Genes Dev 21:1292-315. 2007
    ..The relatively young field of regenerative medicine strives to develop therapies aimed at improving regenerative processes in humans and is predicated on >40 ..
  23. pmc Mesenchymal stem cell-based therapies in regenerative medicine: applications in rheumatology
    Marie Maumus
    INSERM, U844, Montpellier, F 34091 France
    Stem Cell Res Ther 2:14. 2011
    ....
  24. ncbi Mesenchymal stromal cell therapy: a revolution in Regenerative Medicine?
    M E Bernardo
    Dipartimento di Ematologia ed Oncologia Pediatrica, IRCCS Ospedale Pediatrico Bambino Gesù, Roma, Italy
    Bone Marrow Transplant 47:164-71. 2012
    ..These fundamental properties are being tested within a novel therapeutic field defined as Regenerative Medicine. This review deals with recent research on the anti-inflammatory/reparative properties of MSCs and ..
  25. ncbi Introduction to stem cells and regenerative medicine
    George Kolios
    Laboratory of Pharmacology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece
    Respiration 85:3-10. 2013
    ..This review is an introduction to the world of stem cells and discusses their definition, origin, and classification, as well as applications of these cells in regenerative medicine.
  26. ncbi Perivascular cells for regenerative medicine
    Mihaela Crisan
    Erasmus MC Stem Cell Institute, Department of Cell Biology, Rotterdam, The Netherlands
    J Cell Mol Med 16:2851-60. 2012
    Mesenchymal stem/stromal cells (MSC) are currently the best candidate therapeutic cells for regenerative medicine related to osteoarticular, muscular, vascular and inflammatory diseases, although these cells remain heterogeneous and ..
  27. ncbi Stem cells: a revolution in therapeutics-recent advances in stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies
    M Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Clin Pharmacol Ther 82:252-64. 2007
    ..on embryonic, fetal, amniotic, umbilical cord blood, and adult stem cells has constituted a revolution in regenerative medicine and cancer therapies by providing the possibility of generating multiple therapeutically useful cell types...
  28. pmc Reprogrammed cells for disease modeling and regenerative medicine
    Anne B C Cherry
    Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Boston, MA, USA
    Annu Rev Med 64:277-90. 2013
    ....
  29. ncbi Nanotechnologies in regenerative medicine
    Sarka Kubinova
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Minim Invasive Ther Allied Technol 19:144-56. 2010
    ..To cover some of the latest nanotechnology trends in regenerative medicine, this review will focus on the use of nanomaterials for tissue engineering and cell therapy...
  30. ncbi The design and use of animal models for translational research in bone tissue engineering and regenerative medicine
    George F Muschler
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Tissue Eng Part B Rev 16:123-45. 2010
    ..of animal models for the evaluation, comparison, and systematic optimization of tissue engineering and regenerative medicine strategies related to bone tissue...
  31. ncbi Nanotechnology for regenerative medicine
    Dongwoo Khang
    Division of Engineering, Brown University, Providence, RI 02912, USA
    Biomed Microdevices 12:575-87. 2010
    ..This review paper discusses several of the latest nanotechnology findings in regenerative medicine (also now called nanomedicine) as well as their relative levels of success.
  32. ncbi A review on endogenous regenerative technology in periodontal regenerative medicine
    Fa Ming Chen
    Department of Periodontology and Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi an, Shaanxi, People s Republic of China
    Biomaterials 31:7892-927. 2010
    ....
  33. ncbi A brief definition of regenerative medicine
    Chris Mason
    Regen Med 3:1-5. 2008
  34. ncbi Mesenchymal stem cell-based therapy: a new paradigm in regenerative medicine
    Neeraj Kumar Satija
    Stem Cell and Gene Therapy Research Group, Institute of Nuclear Medicine and Allied Sciences, Lucknow Road, Timarpur, Delhi, India
    J Cell Mol Med 13:4385-402. 2009
    ....
  35. ncbi WNT signaling in stem cell biology and regenerative medicine
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Curr Drug Targets 9:565-70. 2008
    ..Recombinant WNT protein or WNT mimetic (circular peptide, small molecule compound, or RNA aptamer) in combination with Notch mimetic, FGF protein, and BMP protein opens a new window to tissue engineering for regenerative medicine.
  36. ncbi A chemical approach to stem-cell biology and regenerative medicine
    Yue Xu
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 453:338-44. 2008
    ..Such therapeutics can act on target cells or their niches in vivo to promote cell survival, proliferation, differentiation, reprogramming and homing...
  37. ncbi Human mesenchymal stem cells: a bank perspective on the isolation, characterization and potential of alternative sources for the regeneration of musculoskeletal tissues
    Lorenzo Moroni
    Muscoloskeletal Tissue Bank, Rizzoli Orthopaedic Institute, Bologna, Italy
    J Cell Physiol 228:680-7. 2013
    ..stem cells (hMSCs) in different tissues is stirring up a tremendous interest as a cell source for regenerative medicine therapies...
  38. ncbi Regulation of cell proliferation by NADPH oxidase-mediated signaling: potential roles in tissue repair, regenerative medicine and tissue engineering
    Elsa C Chan
    Bernard O Brien Institute of Microsurgery, 42 Fitzroy Street, Fitzroy, Victoria 3065, Australia
    Pharmacol Ther 122:97-108. 2009
    ..Thus modulating NADPH oxidase may have significant impacts on regenerative medicine and tissue engineering, such as growing heart muscle.
  39. ncbi Cultivated corneal endothelial transplantation in a primate: possible future clinical application in corneal endothelial regenerative medicine
    Noriko Koizumi
    Department of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe City, Japan
    Cornea 27:S48-55. 2008
    ..To review our attempt to devise a method of cultivated corneal endothelial transplantation using primates in which corneal endothelium, like that of humans, has low proliferative ability...
  40. ncbi Next-generation regenerative medicine: organogenesis from stem cells in 3D culture
    Yoshiki Sasai
    Neurogenesis and Organogenesis Group, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Cell Stem Cell 12:520-30. 2013
    ..This new area of stem cell research-the spatiotemporal control of dynamic cellular interactions-will open a new avenue for next-generation regenerative medicine.
  41. ncbi Scaffold-free cell delivery for use in regenerative medicine
    Jens M Kelm
    Competence Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Switzerland
    Adv Drug Deliv Rev 62:753-64. 2010
    ..of cell-based therapies for diseased tissues is one of the most promising research directions in regenerative medicine. Cell-delivery methods are an essential part of cell therapy concepts...
  42. pmc Microfabricated modular scale-down device for regenerative medicine process development
    Marcel Reichen
    Department of Biochemical Engineering, University College London, London, United Kingdom
    PLoS ONE 7:e52246. 2012
    ..However, for regenerative medicine present smaller scale culture methods cannot cope with the wide range of processing variables that need to ..
  43. ncbi Nasal septum-derived multipotent progenitors: a potent source for stem cell-based regenerative medicine
    Abbas Shafiee
    Stem Cell Biology Department, Stem Cell Technology Research Center, Tehran, Iran
    Stem Cells Dev 20:2077-91. 2011
    ..In conclusion, NSP could be considered as an alternative autologous cell source that can bring them to the top of therapeutic applications...
  44. pmc Development of Sendai virus vectors and their potential applications in gene therapy and regenerative medicine
    Mahito Nakanishi
    Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology AIST, 1 1 1 Higashi, Central 4, Tsukuba, Ibaraki, 305 8562, Japan
    Curr Gene Ther 12:410-6. 2012
    ..These technologies are also being applied in regenerative medicine as tools to reprogram cell genomes to a pluripotent state and to other cell lineages...
  45. ncbi Dental pulp cells for induced pluripotent stem cell banking
    N Tamaoki
    Department of Oral and Maxillofacial Science, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu City, Gifu 501 1194, Japan
    J Dent Res 89:773-8. 2010
    ..Analysis of these data demonstrates the promising potential of DPC collections as a source of iPS cell banks for use in regenerative medicine.
  46. ncbi Capturing epidermal stemness for regenerative medicine
    Yann Barrandon
    Department of Experimental Surgery, Lausanne University Hospital, Switzerland
    Semin Cell Dev Biol 23:937-44. 2012
    ..Finally, medicinal stem cells are expansive to produce and reimbursement of costs by health insurances is a major concern in many countries...
  47. pmc Electrospun nanofibers for regenerative medicine
    Wenying Liu
    Department of Energy, Environmental and Chemical Engineering, Washington University in St Louis, St Louis, MO 63130, USA
    Adv Healthc Mater 1:10-25. 2012
    This Progress Report reviews recent progress in applying electrospun nanofibers to the emerging field of regenerative medicine. It begins with a brief introduction to electrospinning and nanofibers, with a focus on issues related to the ..
  48. ncbi Concise review: aldehyde dehydrogenase bright stem and progenitor cell populations from normal tissues: characteristics, activities, and emerging uses in regenerative medicine
    Andrew E Balber
    Cicada Biopharmaceutical Consulting, Durham, North Carolina 27707, USA
    Stem Cells 29:570-5. 2011
    ..ALDH activity can play several physiological roles in stem and progenitor cells that may potentiate their utility in cell therapy...
  49. pmc Paracrine proangiopoietic effects of human umbilical cord blood-derived purified CD133+ cells--implications for stem cell therapies in regenerative medicine
    Janina Ratajczak
    Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky 40202, USA
    Stem Cells Dev 22:422-30. 2013
    ..CD133+ cells, which are akin to CD34+ cells, are a potential source of stem cells in regenerative medicine. However, the lack of convincing donor-derived chimerism in the damaged organs of patients treated with ..
  50. pmc Immunogenicity of pluripotent stem cells and their derivatives
    Patricia E de Almeida
    Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA 94305 5454, USA
    Circ Res 112:549-61. 2013
    ..stem cells to self-renew and differentiate into all somatic cell types brings great prospects to regenerative medicine and human health...
  51. pmc Introduction to induced pluripotent stem cells: advancing the potential for personalized medicine
    Johnathan D Ebben
    Brain Tumor Research Laboratory, Department of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
    World Neurosurg 76:270-5. 2011
    ..pluripotent stem (iPS) cell technology has enormous potential to advance medical therapy by personalizing regenerative medicine and creating novel human disease models for research and therapeutic testing...
  52. pmc Regenerative medicine for the treatment of musculoskeletal overuse injuries in competition horses
    Paola Torricelli
    Laboratory of Preclinical and Surgical Studies, Research Institute Codivilla Putti, Rizzoli Orthopaedic Institute, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Int Orthop 35:1569-76. 2011
    Tissue repair in musculoskeletal injuries is often a slow and sometimes incomplete process. Regenerative medicine based on the use of growth factors (GFs) and cell therapy is aimed at improving the quality and speed of tendon and ..
  53. ncbi Potential of endogenous regenerative technology for in situ regenerative medicine
    Eduardo Anitua
    Biotechnology Institute, Vitoria, Spain
    Adv Drug Deliv Rev 62:741-52. 2010
    ..The next generations of engineering strategies together with some of the most interesting therapeutic applications are discussed together with the future challenges in the field...
  54. pmc Background mutations in parental cells account for most of the genetic heterogeneity of induced pluripotent stem cells
    Margaret A Young
    Department of Internal Medicine, Division of Oncology, Section of Stem Cell Biology, Washington University, St Louis, MO 63110, USA
    Cell Stem Cell 10:570-82. 2012
    ..These findings have implications for the development and therapeutic use of cells that are reprogrammed by any method...
  55. ncbi Strategies and new developments in the generation of patient-specific pluripotent stem cells
    Shinya Yamanaka
    Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606 8507, Japan
    Cell Stem Cell 1:39-49. 2007
    ..Generating pluripotent stem cells directly from cells obtained from patients is one of the ultimate goals in regenerative medicine. Two "reprogramming" strategies for the generation of pluripotent stem cells from somatic cells have been ..
  56. pmc Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature
    Patrick Au
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Blood 111:4551-8. 2008
    ..mesenchymal stem cells (hMSCs) for use as vascular progenitor cells in tissue engineering and regenerative medicine. hMSCs expressed a panel of smooth muscle markers in vitro including the cardiac/smooth muscle-specific ..
  57. ncbi Three-dimensional high-density co-culture with primary tenocytes induces tenogenic differentiation in mesenchymal stem cells
    Philipp R A Schneider
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilian University of Munich, Pettenkoferstrasse 11, 80336 Munich, Germany
    J Orthop Res 29:1351-60. 2011
    Mesenchymal stem cells (MSCs) have potential applications in regenerative medicine and tissue engineering and may represent an attractive option for tendon repair and regeneration...
  58. ncbi Mesenchymal stem cells and progenitor cells in connective tissue engineering and regenerative medicine: is there a future for transplantation?
    Andres Hilfiker
    Leibniz Research Laboratories for Biotechnology and Artificial Organs LEBAO, Hannover Medical School, Carl Neuberg Strase 1, 30625, Hannover, Germany
    Langenbecks Arch Surg 396:489-97. 2011
    ..The purpose of this article is to review the progress of TE technology, focusing on mesenchymal stem cells (MSC) as a cell source for artificial functional tissue...
  59. ncbi Regenerative medicine using adult neural stem cells: the potential for diabetes therapy and other pharmaceutical applications
    Tomoko Kuwabara
    Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology, Central 4, 1 1 4 Higashi, Tsukuba Science City 305 8562, Japan
    J Mol Cell Biol 4:133-9. 2012
    ..Here, we review recent findings regarding the use of adult OB NSCs as a potential diabetes cure, and discuss the potential of OB NSC-based pharmaceutical applications for neuronal diseases and mental disorders...
  60. ncbi Derivation of GMP raw materials for use in regenerative medicine: hESC-based therapies, progress toward clinical application
    Z A Hewitt
    Sheffield Stem Cell Derivation Facility, Centre for Stem Cell Biology, University of Sheffield, Sheffield, UK
    Clin Pharmacol Ther 82:448-52. 2007
    ....
  61. pmc Electrospun silk biomaterial scaffolds for regenerative medicine
    Xiaohui Zhang
    Department of Chemical and Biological Engineering, Tufts University, Medford, MA 02155, USA
    Adv Drug Deliv Rev 61:988-1006. 2009
    ..Scaffolds can be generated that are useful for tissue engineering and regenerative medicine since they mimic the nanoscale properties of certain fibrous components of the native extracellular matrix ..
  62. ncbi Biomaterials and mesenchymal stem cells for regenerative medicine
    Nina Zippel
    Department of Natural, Sciences, University of Applied Sciences Bonn Rhein Sieg, Rheinbach, Germany
    Recent Pat Biotechnol 4:1-22. 2010
    The reconstruction of hard and soft tissues is a major challenge in regenerative medicine, since diseases or traumas are causing increasing numbers of tissue defects due to the aging of the population...
  63. ncbi Emerging use of stem cells in regenerative medicine
    Adrian K K Teo
    Laboratory for Regenerative Medicine, University of Cambridge, West Forvie Building, Forvie Site, Robinson Way, Cambridge CB2 0SZ, UK
    Biochem J 428:11-23. 2010
    Stem cells represent a unique opportunity for regenerative medicine to cure a broad number of diseases for which current treatment only alleviates symptoms or retards further disease progression...
  64. ncbi Role of mesenchymal stem cells in regenerative medicine: application to bone and cartilage repair
    Froilan Granero-Molto
    University of North Carolina at Chapel Hill, Division of Endocrinology, Department of Pediatrics, 3341 Medical Biomolecular Research Building, 103 Mason Farm Road Campus Box 7039, Chapel Hill North Carolina 27599 7239, USA
    Expert Opin Biol Ther 8:255-68. 2008
    ..Mesenchymal stem cells (MSC) are multipotent cells with the ability to differentiate into mesenchyme-derived cells including osteoblasts and chondrocytes...
  65. ncbi Appendage regeneration in adult vertebrates and implications for regenerative medicine
    Jeremy P Brockes
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
    Science 310:1919-23. 2005
    The regeneration of complex structures in adult salamanders depends on mechanisms that offer pointers for regenerative medicine. These include the plasticity of differentiated cells and the retention in regenerative cells of local cues ..
  66. ncbi Amniotic membrane and amniotic fluid-derived cells: potential tools for regenerative medicine?
    Ornella Parolini
    Centro di Ricerca E Menni, Fondazione Poliambulanza Istituto Ospedaliero, Via Bissolati, 57, 25124 Brescia, Italy
    Regen Med 4:275-91. 2009
    ..in recent years as a possible reserve of stem cells that may be useful for clinical application in regenerative medicine. Many studies have been conducted to date in terms of the differentiation potential of these cells, with ..
  67. ncbi Stem cell and progenitor cell therapy in peripheral artery disease. A critical appraisal
    Holger Lawall
    Angiology Diabetology, SRH Klinikum Karlsbad Langensteinbach, Karlsbad, Germany
    Thromb Haemost 103:696-709. 2010
    ..Preliminary evidence has established its safety, feasibility and effectiveness on several important endpoints. Several large endpoints studies are underway to further consolidate this evidence...
  68. ncbi Sources of stem cells for regenerative medicine
    JENNIFER HIPP
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157, USA
    Stem Cell Rev 4:3-11. 2008
    The shortage of organ donors for regenerative medicine has stimulated research on stem cells as a potential resource for cell-based therapy. Stem cells have been used widely for regenerative medicine applications...
  69. ncbi Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering
    Stephen M Richardson
    Tissue Injury and Repair Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK
    J Cell Physiol 222:23-32. 2010
    ..Here we discuss the prospects of using MSCs in regenerative medicine and summarize the advantages and disadvantages of these cells in articular cartilage and IVD tissue ..
  70. ncbi The role of hypoxia in bone marrow-derived mesenchymal stem cells: considerations for regenerative medicine approaches
    Ruud Das
    Department of Orthopaedics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Tissue Eng Part B Rev 16:159-68. 2010
    Bone marrow-derived mesenchymal stem cells (MSCs) have demonstrated potential for regenerative medicine strategies...
  71. ncbi Nanotechnology for regenerative medicine: nanomaterials for stem cell imaging
    Aniruddh Solanki
    Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Nanomedicine (Lond) 3:567-78. 2008
    ..This review details the current challenges in regenerative medicine, the current applications of nanoparticles in stem cell biology and further potential of nanotechnology ..
  72. ncbi Tissue engineering: creation of long-lasting blood vessels
    Naoto Koike
    Edwin L Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 428:138-9. 2004
    The construction of stable blood vessels is a fundamental challenge for tissue engineering in regenerative medicine. Although certain genes can be introduced into vascular cells to enhance their survival and proliferation, these ..
  73. ncbi Nanoparticles as tools to study and control stem cells
    L Ferreira
    Center of Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal
    J Cell Biochem 108:746-52. 2009
    ..awareness of material science and tissue engineering researchers regarding the potential of stem cells for regenerative medicine, and advances in stem cell biology have contributed towards the boost of this research field in the last ..
  74. pmc Fully functional bioengineered tooth replacement as an organ replacement therapy
    Etsuko Ikeda
    Department of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Chiba 278 8510, Japan
    Proc Natl Acad Sci U S A 106:13475-80. 2009
    ..This study represents a substantial advance and emphasizes the potential for bioengineered organ replacement in future regenerative therapies...
  75. pmc New perspectives in human stem cell therapeutic research
    Alan Trounson
    California Institute for Regenerative Medicine, 210 King Street, San Francisco, CA 94107, USA
    BMC Med 7:29. 2009
    ..The Californian stem cell initiative (California Institute for Regenerative Medicine) has engendered global collaboration for this new medicine that will now also be supported by the US ..
  76. ncbi Induced pluripotent stem cells: developmental biology to regenerative medicine
    Timothy J Nelson
    Marriott Heart Disease Research Program, Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Nat Rev Cardiol 7:700-10. 2010
    ..cells with ectopic stemness factors to bioengineer pluripotent autologous stem cells signals a new era in regenerative medicine. The study of developmental biology has provided a roadmap for cardiac differentiation from embryonic ..
  77. pmc Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach
    Jordan R Plews
    Biomedical Science Department, Centre for Stem Cell Biology, University of Sheffield, Sheffield, United Kingdom
    PLoS ONE 5:e14397. 2010
    ..Thus a method to change cell fate without using DNA will be very useful in regenerative medicine.
  78. ncbi Mesenchymal stem cells: a promising candidate in regenerative medicine
    Ye Chen
    College of Life Sciences, Zhejiang University, Hangzhou 310058, PR China
    Int J Biochem Cell Biol 40:815-20. 2008
    ..These properties of mesenchymal stem cells make them promising candidates for use in regenerative medicine and may also serve as efficient delivery vehicles in site-specific therapy.
  79. ncbi Small molecules in stem cell self-renewal and differentiation
    R C Schugar
    Stem Cell Research Center, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Gene Ther 15:126-35. 2008
    The use of stem cells in regenerative medicine is a promising approach to the treatment of disease and injury...
  80. ncbi Stem cells, ageing and the quest for immortality
    Thomas A Rando
    Geriatric Research, Education and Clinical Center GRECC, VA Palo Alto Health Care System, Stanford, California 94305, USA
    Nature 441:1080-6. 2006
    ..will be critical to the success of any therapeutic application of stem cells in the emerging field of regenerative medicine with respect to tissue injury, degenerative diseases or normal functional declines that accompany ageing.
  81. ncbi Regenerative endodontics: a review of current status and a call for action
    Peter E Murray
    Department of Endodontics, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, FL 33328, USA
    J Endod 33:377-90. 2007
    ..By providing an overview of the methodological issues required to develop potential regenerative endodontic therapies, we hope to present a call for action to develop these therapies for clinical use...
  82. ncbi Stromal cell-derived factor-1 (SDF-1): homing factor for engineered regenerative medicine
    Ting Ting Lau
    Nanyang Technological University, School of Chemical and Biomedical Engineering, Division of Bioengineering, 70 Nanyang Drive, N1 3 B2 13, Singapore
    Expert Opin Biol Ther 11:189-97. 2011
    ....
  83. ncbi Artificial corneas: a regenerative medicine approach
    M Griffith
    University of Ottawa Eye Institute, 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada
    Eye (Lond) 23:1985-9. 2009
    ..The tissue-engineered matrices can either be produced as sterile acellular matrices, or complete with functional cells, ready for implantation...
  84. ncbi Smart biomaterials design for tissue engineering and regenerative medicine
    Mark E Furth
    Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Biomaterials 28:5068-73. 2007
    As a prominent tool in regenerative medicine, tissue engineering (TE) has been an active field of scientific research for nearly three decades...
  85. pmc Potential role of stem cells in management of COPD
    Tillie L Hackett
    UBC James Hogg Research Centre, Heart and Lung Institute, St Paul s Hospital, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 5:81-8. 2010
    ..Herein we review the current literature on the characterization of resident stem and progenitor cell niches within the lung, the contribution of mesenchymal stem cells to lung regeneration, and advances in bioengineering of lung tissue...
  86. ncbi Human amniotic membrane as an alternative source of stem cells for regenerative medicine
    Silvia Díaz-Prado
    Department of Medicine, INIBIC University of A Coruña, Spain CIBER BBN Cellular Therapy Area, Spain
    Differentiation 81:162-71. 2011
    ..has considerable advantageous characteristics to be considered as an attractive material in the field of regenerative medicine. It has low immunogenicity, anti-inflammatory properties and their cells can be isolated without the ..
  87. ncbi Human gingiva-derived mesenchymal stem cells are superior to bone marrow-derived mesenchymal stem cells for cell therapy in regenerative medicine
    Geetanjali B Tomar
    National Center for Cell Science, University of Pune Campus, Pune 411007, India
    Biochem Biophys Res Commun 393:377-83. 2010
    ..we reveal that human gingiva is a better source of MSCs than bone marrow, and large number of functionally competent clinical grade MSCs can be generated in short duration for cell therapy in regenerative medicine and tissue engineering.
  88. ncbi From kidney development to drug delivery and tissue engineering strategies in renal regenerative medicine
    Patricia Y W Dankers
    Department of Pathology and Medical Biology, Stem Cells and Tissue Engineering Group, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Control Release 152:177-85. 2011
    ..As a consequence, many dialysis patients remain in poor health. With the development of regenerative medicine, and particularly tissue engineering and novel drug delivery strategies, alternative routes for renal ..
  89. pmc Very small embryonic-like stem cells: biology and therapeutic potential for heart repair
    Ewa K Zuba-Surma
    Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
    Antioxid Redox Signal 15:1821-34. 2011
    ..The purpose of this review is to summarize the current evidence regarding the biologic features of VSELs, and to discuss their potential as cellular substrates for therapeutic cardiac repair...
  90. ncbi Endogenous lung stem cells: what is their potential for use in regenerative medicine?
    Ivan Bertoncello
    Australian Stem Cell Centre, PO Box 8002, Monash University LPO, Clayton, Victoria 3168, Australia
    Expert Rev Respir Med 4:349-62. 2010
    ..have generated considerable interest in harnessing the potential of adult and embryonic stem cells in regenerative medicine. Stem cell-based therapies are a particularly attractive option for the treatment of intractable lung ..
  91. ncbi [Stem cells from fatty tissue : A new resource for regenerative medicine?]
    J W Kuhbier
    Klinik für Plastische, Hand und Wiederherstellungschirurgie, Medizinische Hochschule Hannover, Deutschland
    Chirurg 81:826-32. 2010
    ..They also revealed immunomodulatory effects and improved the clinical status in immunological diseases.In conclusion ASCs are comparable to bone marrow-derived stem cells concerning possible applications in clinical medicine...
  92. pmc Regenerative medicine as applied to solid organ transplantation: current status and future challenges
    Giuseppe Orlando
    Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
    Transpl Int 24:223-32. 2011
    In the last two decades, regenerative medicine has shown the potential for "bench-to-bedside" translational research in specific clinical settings...
  93. ncbi Genetic engineering for skeletal regenerative medicine
    Charles A Gersbach
    Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Annu Rev Biomed Eng 9:87-119. 2007
    The clinical challenges of skeletal regenerative medicine have motivated significant advances in cellular and tissue engineering in recent years...
  94. ncbi Will cell reprogramming resolve the embryonic stem cell controversy? A narrative review
    Carl Power
    Centenary Institute, University of Sydney, and The Royal Prince Alfred Hospital, Sydney, Australia
    Ann Intern Med 155:114-21. 2011
    ..It also argues that induced pluripotent stem cells are more ethically problematic than most people believe and that cell reprogramming will not solve the stem cell controversy but complicate it further...
  95. ncbi Amniotic fluid-derived stem cells in regenerative medicine research
    Sunyoung Joo
    Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Arch Pharm Res 35:271-80. 2012
    The stem cells isolated from amniotic fluid present an exciting possible contribution to the field of regenerative medicine and amniotic fluid-derived stem (AFS) cells have significant potential for research and therapeutic applications...
  96. ncbi Stem cells have the potential to rejuvenate regenerative medicine research
    David J Eve
    Department of Neurosurgery and Brain Repair, University of South Florida College of Medicine, Tampa, FL, USA
    Med Sci Monit 16:RA197-217. 2010
    ..featuring the use of stem cells in regenerative processes supports the idea that they are revolutionizing regenerative medicine research...
  97. ncbi NO-cGMP signaling and regenerative medicine involving stem cells
    K S Madhusoodanan
    The Brown Foundation Institute of Molecular Medicine, University of Texas Houston Health Science Center, 1825 Pressler Street, Houston, TX 77030, USA
    Neurochem Res 32:681-94. 2007
    ..We believe that manipulating the NO-cGMP signaling system will be an important tool for large scale generation of lineage committed precursor cells to be used for regenerative therapies...
  98. ncbi Stem cell sources for regenerative medicine: the immunological point of view
    Olivier Preynat-Seauve
    Laboratory of Immuno Hematology, Geneva University Hospital, Geneva, Switzerland
    Semin Immunopathol 33:519-24. 2011
    ..fetuses, or adult organs, harboring different properties, and thus providing multiple strategies of regenerative medicine for different diseases...
  99. ncbi Mammalian regeneration and regenerative medicine
    Ken Muneoka
    Division of Developmental Biology, Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    Birth Defects Res C Embryo Today 84:265-80. 2008
    ..this review we discuss how the study of endogenous regenerating mammalian systems is enhancing our understanding of regenerative mechanisms and helping to shed light on the development of therapeutic strategies in regenerative medicine.
  100. pmc Stem cells: roadmap to the clinic
    George Q Daley
    Stem Cell Transplantation Program, Division of Pediatric Hematology Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Boston, Massachusetts, USA
    J Clin Invest 120:8-10. 2010
    ..They also highlight the challenges to be faced in translating what is indeed highly promising science into proven therapies that will regenerate and repair diseased tissues...
  101. pmc Mesenchymal stem cells for bone repair and metabolic bone diseases
    Anita H Undale
    Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905, USA
    Mayo Clin Proc 84:893-902. 2009
    ..The field of regenerative medicine is still facing considerable challenges; however, with the progress achieved thus far, the promise of stem ..

Research Grants81

  1. Revitalizing Allografts for Craniofacial Reconstruction
    Edward Schwarz; Fiscal Year: 2007
    ..by applicant): Maximizing bone repair and regeneration continues to be a major goal in the field of regenerative medicine. Bone regeneration presents a major challenge for the reconstruction of craniofacial bones damaged by ..
  2. "Smart" Materials to Engineer a More Complete Stem Cell Niche
    Adam Engler; Fiscal Year: 2009
    ..Provided by the applicant) Abstract: One of the recent paradigm shifts in stem cell biology and regenerative medicine has been the discovery that stem cells can begin to differentiate into adult tissue cells when exposed to ..
  3. Enabling Strategies for Growing Collagenous Tissues
    LAURA E contact NIKLASON; Fiscal Year: 2010
    ..Only by fundamentally understanding the processes that govern matrix formation in regenerative medicine can we successfully design functional connective tissues...
  4. Discovery of Small Molecule MBT Domain Antagonists
    STEPHEN VERNON FRYE; Fiscal Year: 2010
    ..significance in the fields of epigenetics, oncology, developmental biology, neurology, stem cell fate and regenerative medicine.[3-5] The creation of a 'tool-kit'of potent, selective, well-characterized and cell-penetrant ..
  5. Rac GTPase signaling during embryonic salivary gland branching morphogenesis
    Sharon Sequeira; Fiscal Year: 2012
    ..salivary gland organogenesis will be of considerable significance to the fields of tissue engineering and regenerative medicine and to future studies examining the function and possible deregulation of Rac signaling in salivary gland ..
  6. Novel, Rapidly Translatable Technologies for Healing Long Bone Segmental Defects
    Christopher H Evans; Fiscal Year: 2010
    This application addresses broad Challenge Area (11): Regenerative Medicine, and specific Challenge Topic 11-AR-101 Musculoskeletal and Skin Regeneration Every year, over a million Americans are hospitalized for bone fractures at a ..
  7. Remote-control mouse-implantable micropumps for establishment of regenerative cap
    JUAN GABRIEL contact SANTIAGO; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Our application addresses broad Challenge Area 11, "Regenerative Medicine", and specific Challenge Topic 11-GM-101, "Establishment of regenerative capabilities"...
  8. Targeting p53-Dependent Repigmentation in Vitiligo
    TAMARA G TERZIAN; Fiscal Year: 2013
    ..Caroline Le Poole (collaborator). Dr. Roop is the Director of the Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology (CRMSB) at UCD and Professor of Dermatology...
  9. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..b>Regenerative medicine seeks to devise new ways to repair or replace damaged tissues and organs for millions of patients who ..
  10. Role of murine induced pluripotent stem cells on the correction of cardiac and sk
    Diego Fraidenraich; Fiscal Year: 2010
    ..This feature places them at the center of the regenerative medicine arena...
  11. Heat Shock Effects on Human Mesenchymal Stem Cell Differentiation in Hydrogel
    Sihong Wang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Tissue engineering combined with stem cells, an emerging field of regenerative medicine, holds promise for the restoration of tissues and organs damaged by diseases, aging, and trauma...
  12. The Regulation of Salivary Gland Regeneration by P2Y2 Nucleotide Receptors
    GARY ANDREW WEISMAN; Fiscal Year: 2013
    b>Regenerative medicine represents an exciting new approach in the treatment of human disease...
  13. Implantation of physiologically functional bioengineered innervated IAS construct
    Khalil N Bitar; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Challenge Area (11) Regenerative Medicine: 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, hematology, kidneys and urological system...
  14. Studying a novel regulator of GBM tumorigeneis: the role of CK2alpha in maintaini
    Gordon Li; Fiscal Year: 2013
    ..Irv Weissman-the Director of the Institute for Stem Cell Biology and Regenerative Medicine at Stanford University and a leader in the field of stem cell research who has vast experience with ..
  15. DNA Methylation Control Hematopoietic Stem Cell Lineage Differentiation
    GRANT ANTHONY CHALLEN; Fiscal Year: 2013
    ..As part of the Center for Cell and Gene Therapy (CAGT) and the Stem Cells and Regenerative Medicine (STaR) Center, I will have access to diverse core facilities with expertise in microarray, flow cytometry, ..
  16. Analysis of the leukemic stem cell niche in chronic myeloid leukemia
    DANIELA SANDRA KRAUSE; Fiscal Year: 2013
    ..David Scadden's laboratory at The Center for Regenerative Medicine and Massachusetts General Hospital (MGH)...
  17. INDUCIBLE PLURIPOTENT STEM CELLS AND KIDNEY REGENERATION
    JOSEPH VINCENT BONVENTRE; Fiscal Year: 2010
    This application addresses broad Challenge Area (11) Regenerative Medicine and specific Challenge Topic, 11-DK-101: Promote regeneration and repair in the digestive system, liver, pancreas, kidneys, hematologic, and urologic system...
  18. Gross Hall Animal Resource Center
    Susan V Bryant; Fiscal Year: 2010
    ..and is enabling breakthroughs in a number of fields, in particular the emerging area of stem cell and regenerative medicine research...
  19. Studying a Human Stem Cell Disease Using iPS Technology
    Steven E Artandi; Fiscal Year: 2010
    ..our understanding of human disease and to allow the development of new cellular therapies for regenerative medicine applications...
  20. Genetic correction of human beta-thalassemic induced pluripotent stem cells
    EIRINI PAPAPETROU; Fiscal Year: 2012
    ..Research: For the promise of induced pluripotent stem cells (iPSCs) in regenerative medicine to be realized, strategies for their precise and safe genetic modification and for purging of residual ..
  21. Regenerating Human Oral Mucosa by Bone Marrow-derived Mesenchymal Stem Cells
    RUBIE ANN RAKIAN; Fiscal Year: 2013
    ..an impact by initiating human bone marrow-derived MSC research exploration of the field of craniofacial regenerative medicine and lay the foundation to further study the molecular complexity and dynamics of native and tissue-..
  22. Inflammation and Cerebral Aneurysm Formation: Targets for Modulation and Vascular
    BRIAN LIM HOH; Fiscal Year: 2013
    ..outstanding scientific and creative environment with collaborators in the Program in Stem Cell Biology and Regenerative Medicine, the McKnight Brain Institute, and the Department of Materials Science and Engineering to guide my ..
  23. Trophokine for regenerative medicine
    Jianmin Fang; Fiscal Year: 2010
    ..These diseases affect millions of Americans and have unmet needs for new therapies. ..
  24. Role of Cited2 in Hematopoiesis
    Yu Chung Yang; Fiscal Year: 2011
    ..abnormal HSC biology, and thus may offer new insights into the therapeutic development targeting HSC for regenerative medicine and for treatment of different hematological malignancies...
  25. Generation of Human iPS Cells via Non-integrating Vectors
    Wen Shu Wu; Fiscal Year: 2010
    ..Therefore, this is an alternative to the use of human embryonic stem cells for regenerative medicine applications.
  26. There Will Be Blood: Stem Cell Niche Driven Derivation of HSC from ES Cells
    PAUL JOHN SIMMONS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (11) Regenerative Medicine - 11-HL-101* To develop stem cell based therapies for cardiovascular, lung and blood diseases...
  27. Response of Rhesus Sperm to Freezing: Recovery from Osmotic and Oxidative Stress
    Stuart A Meyers; Fiscal Year: 2010
    ..infectious diseases and vaccine development, drug and alcohol addiction, neurological disorders, and regenerative medicine. Similar to human sperm, cryopreserved sperm from NHPs show variable cryoprotection success depending on ..
  28. 3D Differentiation of Mesenchymal Stem Cells in Peptide Amphiphile Matrices
    John B Matson; Fiscal Year: 2011
    ..differentiation toward a certain terminal cell type will play an important role in the emerging field of regenerative medicine. The proposed work details a strategy for inducing the differentiation of human mesenchymal stem cells (..
  29. Gene Networks in Neural Crest-derived Innervation of the Lower Urinary Tract
    E MICHELLE MICHELLE SOUTHARD SMITH; Fiscal Year: 2010
    This application addresses broad Challenge Area (11) Regenerative Medicine and Specific Challenge Topic 11-DK-103 Organ Innervation...
  30. Genetic correction of human beta-thalassemic induced pluripotent stem cells
    EIRINI PAPAPETROU; Fiscal Year: 2013
    ..Research: For the promise of induced pluripotent stem cells (iPSCs) in regenerative medicine to be realized, strategies for their precise and safe genetic modification and for purging of residual ..
  31. Chronic Toll-like Receptor Ligation and Hematopoietic Stem Cell Aging
    Brandt L Esplin; Fiscal Year: 2010
    ..stem cells (HSC) over a lifespan, this system has become an optimal target for studies on aging and regenerative medicine. In light of the recent discovery that microbial toll-like receptor (TLR) ligands can directly impact HSC ..
  32. Development of Adult Pluripotent Very Small Embryonic Like (VSEL) Stem Cells to T
    DENIS OVEREND RODGERSON; Fiscal Year: 2013
    ..Animal studies have indicated the potential of VSELs in regenerative medicine by their ability to repair cardiac tissue after myocardial infarct and their ability to reconstitute te ..
  33. The Molecular Genetics of Early Neurogenesis
    Ethan Bier; Fiscal Year: 2013
    ..The ability to direct gene expression to specific cell types in space and time is an important goal for regenerative medicine. For example, to treat dorsal spinal chord injuries one may wish to direct differentiating stem cells to ..
  34. Identification and Characterization of Adult Salivary Gland Stem Cells
    Soosan Ghazizadeh; Fiscal Year: 2013
    ..These are central issues from the perspective of regenerative medicine targeted to salivary glands...
  35. Molecular Mechanisms of Age-related Impairment of Muscle Regeneration
    Thomas A Rando; Fiscal Year: 2013
    ..of the extensive tissue damage that many veterans have faced and also because there is great interest in regenerative medicine for the many age- related diseases that affect the aging veteran population Tissue regeneration in aged ..
  36. Targeted cell therapy for the treatment of ventricular tachycardia
    KENNETH LAURITA; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (11): Regenerative Medicine and specific Challenge Topic, 11-HL-101: Develop cell-based therapies for cardiovascular, lung, and blood diseases...
  37. Generation of Wunen/LPP3-based therapy for muscular dystrophy
    Hannele Ruohola Baker; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This application addresses broad Challenge Area (11) Regenerative Medicine and specific Challenge Topic 11-AR-101: Musculoskeletal and Skin Tissue Regeneration...
  38. Slit2-mediated expansion of primitive hematopoietic stem cell populations for tra
    Gary Van Zant; Fiscal Year: 2010
    ..Agency: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Challenge Area - (11) Regenerative Medicine Specific challenge topic - 11-DK-101 Promote regeneration and repair in the digestive system, liver, ..
  39. Osteoclasts from pluripotent stem cells as vectors to modify bone marrow environm
    Hector L Aguila; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): This application addresses broad challenge Area (11) "Regenerative Medicine" and specific Challenge Topic 11-HL-101* "Develop cell-based therapies for cardiovascular, lung and blood diseases"...
  40. Histone proline isomerization and gene regulation
    Nobuaki Kikyo; Fiscal Year: 2010
    ..In addition, the results will facilitate the progress of nuclear reprogramming and regenerative medicine, especially creation of patients-derived rejection-free tissues for the purpose of transplantation.
  41. Novel mechanisms to increase beta cell regeneration by p27
    SENTA K GEORGIA; Fiscal Year: 2012
    ..will result in 3 high impact publications within the next 5 years that will advance the field of regenerative medicine and islet biology...
  42. Reprogramming of endothelial cells for improved cardiomyogenicity in vivo
    MELISSA ANN THAL; Fiscal Year: 2012
    ..options, repair of damaged myocardial tissue is still a central therapeutic challenge in cardiovascular regenerative medicine. Currently, bone marrow derived endothelial progenitor cells (BM-EPCs) are being used clinically to ..
  43. East African Cichlids: A Natural Model for Dental Regeneration
    RYAN FREDRIC BLOOMQUIST; Fiscal Year: 2013
    ..addressing morbidities that arise from congenital, traumatic, or infectious pathology lie in the field of regenerative medicine. On the forefront of these therapeutics is the field of regenerative dentistry...
  44. CONTROL OF MUSCLE PROTEIN SYNTHESIS DURING MYOGENESIS
    Charles P Emerson; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Realizing the potential of stem cell biology for regenerative medicine requires a deeper understanding of the fundamental molecular and epigenetic mechanisms that program the ..
  45. Directed differentiation of embryonic stem cells for urologic applications
    James A Bassuk; Fiscal Year: 2010
    ..The specifiic new research capability to be learned is the use of embryonic stem cells (ESCs) in regenerative medicine applications such as tissue engineered repair of the urinary bladder and its associated tract...
  46. CellTrap: A novel solid phase platform for analysis of stem/progenitor cells
    NICANOR I contact MOLDOVAN; Fiscal Year: 2010
    ..Accurate, fast and unbiased methods to detect rare cells in cell suspensions for regenerative medicine are in much need and in short supply...
  47. Adult Tissue Morphogenesis: Functional Regulation of Intussusceptive Angiogenesis
    Steven Mentzer; Fiscal Year: 2013
    ..The goal of this project is the functional regulation of adult intussusceptive angiogenesis;that is, the rapid expansion of microvascular networks for application in both regenerative medicine and tissue engineering.
  48. Regeneration of the Developing Chick Elbow Joint
    Rosalie Anderson; Fiscal Year: 2012
    ..Thus, before joint repair procedures based on regeneration, i.e. regenerative medicine, are to be tested and utilized, there must be an understanding of the regeneration process of the tissues ..
  49. Manipulation of beta-catenin signaling in adult oral cells for tooth regeneration
    Sarah E Millar; Fiscal Year: 2010
    ..provided by applicant): This application addresses broad Challenge Areas (14) Stem Cells and (11) Regenerative Medicine and the specific Challenge Topics 14-DE-101*: Precise Reprogramming of Cells from Oral and Craniofacial ..
  50. TRANSPLANTATION OF TESTIS STEM CELLS IN LARGE ANIMALS
    Ina Dobrinski; Fiscal Year: 2013
    ..and testis cell grafting to be employed in this proposal will enable efficient germ line gene deletion in a large animal model and will establish a pre-clinical platform for work with GSCs in reproductive and regenerative medicine.
  51. Targeted delivery of osteoinductive molecules to biologic HA in bone grafts
    Jennifer L Bain; Fiscal Year: 2012
    ..Autogenous bone is widely used as the gold standard in craniofacial regenerative medicine, but comes with increased morbidity to the patient (3)...
  52. Epigenetic modification of endothelial progenitor cells into multipotent cells
    Rajasingh Johnson; Fiscal Year: 2010
    ..and alternative source for therapeutic cloning to generate pluripotent, autologous stem cells for regenerative medicine. Currently, the benefit of adult stem cell therapies appears to be limited to vascular repair without ..
  53. Mechanisms of Sensory Regeneration
    Mark Warchol; Fiscal Year: 2013
    ..Notably, knowledge acquired from this work will also extend beyond the realm of regenerative medicine. Many inner ear pathologies respond to immunosuppressive therapies...
  54. Processing and Preservation of Human Umbilical Cord Stem Cells for Cell Therapeut
    Alfred Bahnson; Fiscal Year: 2010
    ..is to develop a UC cell product that can be used allogeneically in off-the-shelf products for a number of regenerative medicine applications...
  55. ADULT STEM CELL SUPPRESSION DUE TO ALCOHOL INDUCED MICROENVIRONMENT ALTERATIONS
    Mandi J Lopez; Fiscal Year: 2010
    ..Costs associated with revision spinal fusion surgery were as high as $72,000 each in 2003. Regenerative medicine is a novel therapeutic modality that employs stem cells to promote tissue healing...
  56. Beta-catenin is a molecular target of the Fanconi anemia core complex
    Kim Hien T Dao; Fiscal Year: 2013
    ..Through this experience, as a Clinical Fellow Scholar in the California Institute for Regenerative Medicine Program, she acquired a 2-year postdoctoral research experience under the direction of Dr...
  57. A Novel Approach for Biomaterials Assisted Regeneration of Pulp-Dentin Complex
    Satish Alapati; Fiscal Year: 2013
    ..This award will enable the applicant to obtain training in postnatal dental pulp stem cell-based regenerative medicine, with an emphasis on tissue-engineering the pulp-dentin complex...
  58. Role of TGF-? Signaling in Embryonic Stem Cell Maintenance and Endodermal Differe
    Alan C Mullen; Fiscal Year: 2013
    ..endodermal differentiation and use this knowledge to improve our ability to grow hepatocytes for use in regenerative medicine. To achieve these goals the project will 1) identify the key transcription factors that co- occupy DNA ..
  59. Control of Cardiac Lineage Commitment and Differentiation in Murine Development
    Ibrahim J Domian; Fiscal Year: 2013
    ..understanding the pathophysiologic basis of these diseases and will contribute to the scientific basis of regenerative medicine. Recently, small non-coding RNA molecules called microRNAs (miRNAs) have been shown to regulate gene ..
  60. In utero protein transduction to interrogate inner ear sensory patch formation
    JOHN VINCENT BRIGANDE; Fiscal Year: 2013
    ..Significant barriers to progress in the field of regenerative medicine are the identification f genes that have authentic therapeutic potential and the creation of reliable ..
  61. Gene-Expression Patterns During Hair-Cell Regeneration
    ALBERT JAMES HUDSPETH; Fiscal Year: 2010
    This application addresses broad Challenge Area 11, entitled Regenerative Medicine. The specific Challenge Topic is 11-DC-101, Hair Cell Regeneration and Maintenance...
  62. Development of a human Oct-4 gene-targeted reporter cell line
    GREGORY LENO; Fiscal Year: 2010
    ..Efficiently reprogrammed human cells have viable commercial applications in regenerative medicine.
  63. Wnt Signaling in Hematopoietic Stem Cell Specification and Leukemia
    WILSON KENDRICK CLEMENTS; Fiscal Year: 2013
    ..stem cells (iPSCs) are directed to become tissue specific stem cells such HSCs is a key goal of regenerative medicine. The most obvious approach to defining required regulatory networks is to determine the endogenous ..
  64. Multifunctional Printed Scaffolds for Enhancing Hepatocyte Viability and Function
    Ramille N Shah; Fiscal Year: 2013
    ..research involving the investigation of self-assembling peptide amphiphile nanostructures for regenerative medicine at Northwestern University's Institute for BioNanotechnology in Medicine...
  65. Novel molecular imaging approaches to monitor gene and cell-based therapies
    Shahriar Yaghoubi; Fiscal Year: 2013
    ..gene and cell-based therapies Gene and cell-based therapies have ushered in a new era of opportunities in regenerative medicine and oncology...
  66. Directing Stem Cell Differentiation on Biologically Inspired Micropatterned Surfa
    Anita Shukla; Fiscal Year: 2012
    ..Better understanding of hMSC lineage commitment will allow the development of superior regenerative medicine therapies...
  67. Directed Self Assembly of Complex Branching Micro-Tissues
    JEFFREY R contact MORGAN; Fiscal Year: 2010
    ..3D micro-tissues made in this way may have applications in regenerative medicine, tissue engineering and drug development...
  68. Allogeneic Placental Stem Cells for Tissue Repair and Regeneration
    Vijay Kumar; Fiscal Year: 2010
    ..placental tissue harvested after birth, there is a growing interest in using these stem cells for tissue regenerative medicine purposes...
  69. Non-Enzymatic Cryogenic Isolation of Therapeutic Cells
    MICHAEL JOHN TAYLOR; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): In modern day medicine, cellular therapies, regenerative medicine and tissue engineering all involve technologies for harvesting, expanding, modifying and re-implanting live viable cells and tissues...
  70. Engineered in vivo nuclear fusion: application to regenerative medicine
    Richard C Mulligan; Fiscal Year: 2010
    Engineered in vivo nuclear fusion: application to regenerative medicine. This application addresses broad Challenge Area (11) Regenerative Medicine and specific Challenge Topic, 11-DK-104: Use of Hematopoietic Stem Cells (HSC) to ..
  71. Vascularization of polymeric tissue beds
    Horst A von Recum; Fiscal Year: 2010
    ..entitled Vascularization of Polymeric Tissue Beds, seeks to address the broad Challenge Area of (11) Regenerative Medicine, and the specific Challenge Topic of vascular networks in engineered tissues: 11-EB-101...
  72. Localized immobilization of ephrin-B2 for neurite guidance in 3D culture
    Michael J Moore; Fiscal Year: 2010
    ..b>Regenerative medicine strategies that utilize synthetic or natural materials as permissive environments for maximizing axonal ..
  73. Spinal Fusion Using Adipose Derived Adult Stem Cells
    Jeffrey Gimble; Fiscal Year: 2005
    ..b>Regenerative medicine offers a novel approach to this problem by combining osteoinductive biomaterials and environmental cues ..
  74. Cell Based Therapy for Lung Disease
    Carl W White; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Research Area: Broad Challenge Area 11: Regenerative Medicine. Specific Challenge Topic: 11-HL-101* Develop cell-based therapies for cardiovascular, lung, and blood disease...
  75. Stem Cell Induction of Coronary Arteriogenesis
    William M Chilian; Fiscal Year: 2010
    This application addresses the broad Challenge Area, (11) Regenerative Medicine, and specific Challenge Topic, "11-HL-101, Develop cell-based therapies for cardiovascular, lung, and blood diseases...
  76. HTS-TEETH-A new preservation solution for avulsed teeth
    Robert Van Buskirk; Fiscal Year: 2005
    ..HTS-DCC, HTS-FRS, HTS-AIE and GelStor as well as other custom solutions being utilized by clients in the Regenerative Medicine market...
  77. Novel Studies of Bladder Regeneration in a Rodent Model
    George Christ; Fiscal Year: 2009
    ..Tissue engineering and regenerative medicine technologies represent a potential solution to the deficit of viable bladder tissue associated with these ..
  78. Stimulation of tooth repair and regeneration by interaction with dental meterials
    Jack Ferracane; Fiscal Year: 2009
    ..Advances in regenerative medicine are paving the way for a new era in restorative dentistry and this training will position the candidate to ..
  79. Controlling Intracellular Ice Formation with Antifreeze Proteins
    Lia Campbell; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Long term preservation is crucial as an enabling technology for regenerative medicine products that contain living cells...
  80. Tendon formation mediated by SMAD8 signaling pathway
    David Kaplan; Fiscal Year: 2006
    ..tissues available as a source for implantation and tissue replacement is a novel approach in regenerative medicine. We have been studying novel biomaterials and ex vivo culture systems for ligament tissue engineering, ..
  81. Directed MSC differentiation via controlled transfection
    William Murphy; Fiscal Year: 2007
    ..An emerging approach in regenerative medicine involves transfecting cells with genes that encode inductive growth factors, leading to transgenic ..