Genomes and Genes
Summary: A specialty concerned with the nature and cause of disease as expressed by changes in cellular or tissue structure and function caused by the disease process.
Publications256 found, 100 shown here
- The Human Protein Atlas--a tool for pathologyF Ponten
Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, SE 751 85 Uppsala, Sweden
J Pathol 216:387-93. 2008..Thus, the presented Human Protein Atlas provides a resource for pathology-based biomedical research, including protein science and biomarker discovery.
- Use of virtual microscopy for didactic live-audience presentation in anatomic pathologyDavid J Romer
Department of Pathology, The Ohio State College of Medicine and Public Health, The Ohio State University, Columbus 43210, USA
Ann Diagn Pathol 7:67-72. 2003Didactic presentations on the topic of anatomic pathology in front of a live audience have been largely dependent on the use of standard 2 x 2 inch projection slides (Kodachromes) of selected still images from the topic at hand...
- Critical comparison of 31 commercially available digital slide systems in pathologyMarcial Garcia Rojo
Pathology Department, Hospital General de Ciudad Real, Spain
Int J Surg Pathol 14:285-305. 2006Advances in new technologies for complete slide digitization in pathology have allowed the appearance of a wide spectrum of technologic solutions for whole-slide scanning, which have been classified into motorized microscopes and ..
- The pathology of pulmonary disorders due to Aspergillus sppRichard L Kradin
Department of Pathology, Warren 253, Massachusetts General Hospital, Boston, MA 02114, USA
Arch Pathol Lab Med 132:606-14. 2008..This article reviews the spectrum of pulmonary disorders due to infection by Aspergillus spp, with emphasis on the clinical implications of diagnosis...
- Virtual microscopy in pathology educationFred R Dee
Department of Pathology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Hum Pathol 40:1112-21. 2009..Since that time, it has been successfully implemented into many pathology courses in the United States and around the world, with surveys indicating that about 50% of pathology courses ..
- Selection and interpretation of clinical pathology indicators of hepatic injury in preclinical studiesL Boone
Regulatory Affairs Committee of the American Society for Veterinary Clinical Pathology, USA
Vet Clin Pathol 34:182-8. 2005..the expert recommendations of the Regulatory Affairs Committee of the American Society for Veterinary Clinical Pathology for the use of preclinical, clinical pathology endpoints in assessment of the potential for drug-induced hepatic ..
- The Danish Pathology RegisterBeth Bjerregaard
Department of Pathology, Herlev University Hospital, Herlev, Denmark
Scand J Public Health 39:72-4. 2011The National Board of Health, Denmark in 1997 published guidelines for reporting of pathology data and the Danish Pathology Register (DPR) was established.
- [Immunohistochemical identification of lymph vessels with D2-40 in diagnostic pathology]E Kaiserling
Institut fur Pathologie, Universitatsklinikum, Eberhard Karls Universitat Tubingen
Pathologe 25:362-74. 2004..Despite this relatively broad spectrum of reactivity, we consider D2-40 to be the best commercially available antibody for the delineation of normal, reactive and neoplastic lymphatic endothelial cells...
- The state of the art of the zebrafish model for toxicology and toxicologic pathology research--advantages and current limitationsJan M Spitsbergen
Department of Environmental and Molecular Toxicology and Marine Freshwater Biomedical Sciences Center, Oregon State University, Corvallis, Oregon 97333, USA
Toxicol Pathol 31:62-87. 2003..Therefore, to fully utilize the potential of zebrafish as an animal model for understanding human development, disease, and toxicology we must greatly advance our knowledge on zebrafish diseases and pathology.
- Do prior knowledge, personality and visual perceptual ability predict student performance in microscopic pathology?Laura Helle
Department of Teacher Education, Centre for Learning Research, University of Turku, Turku, Finland
Med Educ 44:621-9. 2010..important for detecting signs of disease as part of diagnostic procedures in, for example, microscopic pathology, radiology and dermatology and as a component of perceptual motor skills in medical procedures such as surgery...
- Review of imaging solutions for integrated quantitative immunohistochemistry in the Pathology daily practiceMarcial Garcia Rojo
Pathology Department, Hospital General de Ciudad Real, Ciudad Real, Spain
Folia Histochem Cytobiol 47:349-54. 2009Immunohistochemistry (IHC) plays an essential role in Pathology. In order to improve reproducibility and standardization of the results interpretation, IHC quantification methods have been developed...
- Molecular pathology of colorectal carcinoma. A systematic review centred on the new role of the pathologistA Remo
Department of Pathology, Mater Salutis Hospital, ULSS21 Legnago, Verona, Italy
Pathologica 104:432-41. 2012..We have summarized the role of genetic/epigenetic changes in the origin of the multiple CRC pathway, taking into account current knowledge of pathogenesis and feasibility of designing novel therapeutic approaches...
- Point-of-care pathology with miniature microscopesJonathan T C Liu
Stony Brook University SUNY Department of Biomedical Engineering, Stony Brook, NY, USA
Anal Cell Pathol (Amst) 34:81-98. 2011....
- Pathology imaging informatics for quantitative analysis of whole-slide imagesSonal Kothari
School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
J Am Med Inform Assoc 20:1099-108. 2013..With the objective of bringing clinical decision support systems to reality, this article reviews histopathological whole-slide imaging informatics methods, associated challenges, and future research opportunities...
- Automated classification of free-text pathology reports for registration of incident cases of cancerV Jouhet
Unite d Epidemiologie, biostatistique et registre des cancers de Poitou Charentes, Faculte de Medecine, Centre Hospitalier Universitaire de Poitiers, Universite de Poitiers, Poitiers Cedex, France vianney
Methods Inf Med 51:242-51. 2012Our study aimed to construct and evaluate functions called "classifiers", produced by supervised machine learning techniques, in order to categorize automatically pathology reports using solely their content.
- The impact of specially designed digital games-based learning in undergraduate pathology and medical educationRani Kanthan
Department of Pathology and Laboratory Medicine, University of Saskatchewan and Saskatoon Health Region, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK, Canada
Arch Pathol Lab Med 135:135-42. 2011..Within the context of ongoing reforms in medical education, specially designed digital games, a form of active learning, are effective, complementary e-teaching/learning resources...
- Applications of image analysis to anatomic pathology: realities and promisesJoan Gil
Department of Pathology, Mt Sinai School of Medicine, New York, New York, USA
Cancer Invest 21:950-9. 2003Image Analysis in Pathology is viewed as an ancillary method meant to provide objective support in the resolution of difficult problems...
- The problems and promise of central pathology review: development of a standardized procedure for the Children's Oncology GroupLisa A Teot
Children s Hospital of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Pediatr Dev Pathol 10:199-207. 2007..Policies regarding pathology review have historically varied but have recently been standardized by the COG...
- Pathology services in developing countries: a challengeHallgrimur Benediktsson
Department of Pathology and Laboratory Medicine, Foothills Medical Centre, C1132, 1903 29 St NW, Calgary, Alberta, Canada T2N 2T9
Arch Pathol Lab Med 131:1636-9. 2007
- Informatics training in pathology residency programsWalter H Henricks
Laboratory Information Services, Division of Pathology and Laboratory Medicine, Cleveland Clinic Foundation, OH 44195, USA
Am J Clin Pathol 118:172-8. 2002Information management is crucial in pathology, and previous reports have stressed the needfor improved informatics training in pathology residency programs...
- Digital transplantation pathology: combining whole slide imaging, multiplex staining and automated image analysisK Isse
Department of Pathology, Division of Transplantation, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Am J Transplant 12:27-37. 2012..trials is evolving toward implementation for low-volume, high-complexity clinical services like transplantation pathology. Cost, complexities of implementation, fluid/evolving standards, and unsettled medical/legal and regulatory ..
- Implementing digital technology to enhance student learning of pathologyC S Farah
School of Dentistry UQ Centre for Clinical Research, University of Queensland, Royal Brisbane and Women s Hospital, Herston, QLD 4029, Australia
Eur J Dent Educ 13:172-8. 2009..This report examines the introduction of digital virtual microscopy technology into the curriculum of the School of Dentistry at the University of Queensland (UQ) in Brisbane, Australia...
- Pathbase and the MPATH ontology. Community resources for mouse histopathologyP N Schofield
The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
Vet Pathol 47:1016-20. 2010..This is a community resource, and it facilitates the sharing of expertise and data among members of the pathology community worldwide...
- Breast cancer testing scandal shines spotlight on black box of clinical laboratory testingKaryn Hede
J Natl Cancer Inst 100:836-7, 844. 2008
- Non-endometrioid carcinomas of the uterine corpus: a review of their pathology with emphasis on recent advances and problematic aspectsPhilip B Clement
Department of Pathology, Vancouver General Hospital and Health Science Centre and the University of Columbia, Vancouver, British Columbia, Canada
Adv Anat Pathol 11:117-42. 2004..7) The spectrum of reactive epithelial changes and other non-neoplastic abnormalities that may mimic serous or clear cell carcinoma...
- Restoration of distorted colour microscopic images from transverse chromatic aberration of imperfect lensesH S Wu
Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA
J Microsc 241:125-31. 2011..Results of real microscopic images are provided. The restored image and the original are compared both visually and quantitatively in terms of the estimated entropies measured for the degree of concentrations using vector distributions...
- A short history of pathology registries, with emphasis on cancer registriesBenedetto Terracini
University of Torino
Soz Praventivmed 48:3-10. 2003..1960s and the 1970s gave little attention to and showed limited enthusiasm for population-based registries of pathology. The latter, in fact, have been marginal to the dramatic evolution of basic conceptual issues such as study ..
- Modern imaging technologies in toxicologic pathology: An overviewXiaoyou Ying
Drug Safety Evaluation, Sanofi Aventis, Bridgewater, New Jersey 08807 0800, USA
Toxicol Pathol 34:815-26. 2006..In toxicologic pathology, the impact of modern imaging technology is becoming apparent from digital histopathology to novel molecular ..
- Informatics for practicing anatomical pathologists: marking a new era in pathology practiceManal Y Gabril
Department of Pathology, London Health Sciences Centre, London, Canada
Mod Pathol 23:349-58. 2010Informatics can be defined as using highly advanced technologies to improve patient diagnosis or management. Pathology informatics had evolved as a response to the overwhelming amount of information that was available, in an attempt to ..
- Pathology in the era of Web 2.0William E Schreiber
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada
Am J Clin Pathol 132:824-8. 2009..Some potential applications of Web 2.0 in pathology and laboratory medicine are discussed, as are the issues that must be considered when adopting this new ..
- Evaluation of an intelligent tutoring system in pathology: effects of external representation on performance gains, metacognition, and acceptanceRebecca S Crowley
Department of Biomedical Informatics, University of Pittsburgh School of Medicine, UPMC Shadyside Cancer Pavilion, Room 307, 5230 Centre Avenue, Pittsburgh, PA 15232, USA
J Am Med Inform Assoc 14:182-90. 2007..Describe impact of tutoring on spectrum of diagnostic skills required for task performance. Identify key features of student-tutor interaction contributing to learning gains...
- College of American Pathologists considerations for the delineation of pathology clinical privilegesEdward W Catalano
Department of Pathology, Palmetto Richland Memorial Hospital, Columbia, South Carolina, USA
Arch Pathol Lab Med 133:613-8. 2009..The College of American Pathologists makes resources available to assist members and their facilities in implementing the new requirements and improving patient care...
- Guidelines on processing and reporting of prostate biopsies: the 2013 update of the pathology committee of the European Randomized Study of Screening for Prostate Cancer (ERSPC)T van der Kwast
Department of Pathology, Princess Margaret Cancer Center, University Health Network, University of Toronto, Canada
Virchows Arch 463:367-77. 2013..Further, an unambiguous and concise pathology reporting is essential for an appropriate clinical decision process...
- Virtual microscopy and digital pathology in training and educationPeter W Hamilton
Centre for Cancer Research and Cell Biology, Queen s University Belfast, UK
APMIS 120:305-15. 2012Traditionally, education and training in pathology has been delivered using textbooks, glass slides and conventional microscopy...
- Laser-assisted microdissection, techniques and applications in pathology (review)Ali Fuat Okuducu
Institute of Pathology, University of Bonn, D 53011 Bonn, Germany
Int J Mol Med 15:763-9. 2005..This review focuses on the two basic techniques of laser-assisted microdissection and on its applications in molecular pathology.
- Recommendations for the evaluation of pathology data in nonclinical safety biomarker qualification studiesJohn E Burkhardt
Abbott Laboratories, Abbott Park, Illinois, USA
Toxicol Pathol 39:1129-37. 2011..conduct of histopathology evaluation in nonclinical safety studies was endorsed by the Society of Toxicologic Pathology (STP) in 2004...
- Error and error reduction in pathologyRonald L Sirota
Department of Pathology, Advocate Lutheran General Hospital, Park Ridge, IL 60068, USA
Arch Pathol Lab Med 129:1228-33. 2005..In fields other than medicine, considerable knowledge has been obtained concerning error and error reduction. This body of knowledge can be successfully applied to pathology in order to make the specialty safer and less error prone.
- Proteomics in pathology, research and practiceChristoph Rocken
Department of Pathology, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
Pathol Res Pract 200:69-82. 2004..In this review, we summarize the recent developments of proteomics in research and pathology, and critically discuss putative limitations and future applications of disease-specific biomarkers...
- Improved prediction of prostate cancer recurrence through systems pathologyCarlos Cordon-Cardo
Memorial Sloan Kettering Cancer Center, New York, NY, USA
J Clin Invest 117:1876-83. 2007We have developed an integrated, multidisciplinary methodology, termed systems pathology, to generate highly accurate predictive tools for complex diseases, using prostate cancer for the prototype...
- Digital photography in anatomical pathologyF J Leong
Mirada Solutions, Oxford, UK
J Postgrad Med 50:62-9. 2004Digital imaging has made major inroads into the routine practice of anatomical pathology and replaces photographic prints and Kodachromes for reporting and conference purposes...
- Evaluating mutant mice: anatomic pathologyC Brayton
Baylor College of Medicine, Houston TX 77030, USA
Vet Pathol 38:1-19. 2001..The role of comparative pathology in research on mutant mouse models of disease is increasing in response to these trends...
- Raising the quality of care during medical missions: a survey to assess the need for clinical and anatomic pathology services in international medical missionsAgne Naujokas
University of California, San Francisco, 1701 Divisadero St, Suite 280, San Francisco, CA 94115, USA
Arch Pathol Lab Med 137:637-41. 2013..Limited publicly available information on the use of pathology services during short-term medical missions (STMMs) shows a dire need for the improved quality of care being ..
- An intelligent tutoring system for visual classification problem solvingRebecca S Crowley
Center for Pathology Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
Artif Intell Med 36:85-117. 2006..This manuscript describes the development of a general intelligent tutoring system for teaching visual classification problem solving...
- Competency-based residency training in pathology: challenges and opportunitiesRobert Folberg
Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA
Hum Pathol 33:3-6. 2002..learning, practice improvement, interpersonal skills and communication, professionalism, and an awareness of pathology's role in a larger health care system...
- Digital pathology: a tool for 21st century neuropathologyMiguel Guzman
Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania Medical Center, 3615 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
Brain Pathol 19:305-16. 2009Digital pathology represents an electronic environment for performing pathologic analysis and managing the information associated with this activity...
- Pathology in drug discovery and developmentAdrian M Jubb
Department of Product Development Oncology, Genentech Inc, South San Francisco, CA, USA
J Pathol 232:99-102. 2014..This Annual Review Issue of the Journal of Pathology highlights the central role for pathology in modern drug discovery and development.
- Effect of a limited-enforcement intelligent tutoring system in dermatopathology on student errors, goals and solution pathsVelma L Payne
Department of Biomedical Informatics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15232, USA
Artif Intell Med 47:175-97. 2009..Determine if the size of the problem-space (domain scope), has an effect on learning gains when using a tutor with limited enforcement...
- E-education in pathology including certification of e-institutionsKlaus Kayser
UICC TPCC, Charite, Charite Platz 1, 10118 Berlin, Germany
Diagn Pathol 6:S11. 2011E-education or electronically transferred continuous education in pathology is one major application of virtual microscopy...
- Effectiveness of an electronic health record-based intervention to improve follow-up of abnormal pathology results: a retrospective record analysisArchana Laxmisan
Houston VA Health Services Research and Development Center of Excellence, Michael E DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA
Med Care 50:898-904. 2012..Health Administration (VA) implemented an electronic health record (EHR)-based intervention that required all pathology results to be transmitted to ordering providers by mandatory automated notifications...
- Attachment of the soluble complement regulator factor H to cell and tissue surfaces: relevance for pathologyM Jozsi
Department of Biological Infection, Hans Knoell Institute for Natural Products Research, Jena, Germany
Histol Histopathol 19:251-8. 2004....
- Utility of whole slide imaging and virtual microscopy in prostate pathologyPhilippe Camparo
Cabinet de Pathologie Amiens, France
APMIS 120:298-304. 2012..The feasibility of using WSI/VM for routine surgical pathology reporting has also been explored...
- Digital pathology: DICOM-conform draft, testbed, and first resultsRalf Zwönitzer
Department of Biometry and Medical Informatics, Otto von Guericke University, Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
Comput Methods Programs Biomed 87:181-8. 2007Hospital information systems are state of the art nowadays. Therefore, Digital Pathology, also labelled as Virtual Microscopy, has gained increased attention...
- Current concepts of enzyme histochemistry in modern pathologyWilliam A Meier-Ruge
Institute of Pathology, University Hospital Basel, Basel, Switzerland
Pathobiology 75:233-43. 2008..With the advent of immunohistochemistry and DNA-oriented molecular pathology techniques, the potential of enzyme histochemistry currently tends to be underrecognized...
- Training mouse pathologists: five years of pathology of mouse models of human disease workshopsJohn P Sundberg
The Jackson Laboratory, Bar Harbor, ME 04609 1500, USA
Toxicol Pathol 35:447-8. 2007
- Flow cytometric DNA and phenotype analysis in pathology. A meeting report of a symposium at the annual conference of the German Society of Pathology, Kiel, Germany, 6-9 June 2000M Nap
Atrium Medical Centre Heerlen, Department of Pathology, The Netherlands
Virchows Arch 438:425-32. 2001..In the third part, from Heerlen, the use of multi-parameter FCM on formalin-fixed paraffin-embedded tissues from solid tumors is discussed as a new development and application in routine surgical pathology.
- Brief communication: the Galler Collection: a little-known historic Swiss bone pathology reference seriesFrank J Rühli
Clinical Paleopathology Unit, Orthopedic University Clinic Balgrist and Institute for the History of Medicine, University of Zurich, Ch 8008 Zurich, Switzerland
Am J Phys Anthropol 121:15-8. 2003..At present, the Galler Collection is located at the National History Museum in Basel (Augustinergasse 2, 4001 Basel, Switzerland, Telephone: +41612665500, Fax: +41612665546)...
- Occupational injuries in a pathology residency programPiotr Kubiczek
Arch Pathol Lab Med 130:146-7. 2006
- Diagnostic decision-making in anatomic pathologyE Foucar
Department of Pathology, Presbyterian Hospital, Albuquerque, NM, USA
Am J Clin Pathol 116:S21-33. 2001In diagnostic pathology, decision-making skills are used to match the facts of a particular case to a diagnostic category...
- Classification in anatomic pathologyE Foucar
Department of Pathology, Presbyterian Hospital, Albuquerque, NM, USA
Am J Clin Pathol 116:S5-20. 2001..However, in spite of the amazing success of pathology classification, it is apparent to everyone that diagnostic disagreements are common, and that patients who ..
- A novel application of mobile phone cameras in undergraduate pathology educationPrashant Sharma
Med Teach 28:745-6. 2006
- OSPE in pathologyM Feroze
Department of Pathology, Academy of Medical Sciences, Pariyaram, Kerala
Indian J Pathol Microbiol 45:53-7. 2002..The questionnaire given to the students revealed a high acceptance rate among them...
- Pathbase: a new reference resource and database for laboratory mouse pathologyPaul N Schofield
Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
Radiat Prot Dosimetry 112:525-8. 2004..The database currently has over 1000 images on-line with 2000 more under curation and presents a paradigm for the development of future databases dedicated to aspects of experimental biology...
- Why is it crucial to reintegrate pathology into cancer research?Jaime Rodriguez-Canales
Laser Capture Microdissection Core and Pathogenetics Unit, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
Bioessays 33:490-8. 2011The integration of pathology with molecular biology is vital if we are to enhance the translational value of cancer research...
- A consensus curriculum for laboratory management training for pathology residentsRonald L Weiss
Dept of Pathology and ARUP Laboratories, University of Utah, 500 Chipeta Way, Salt Lake City, UT 84108, USA
Am J Clin Pathol 136:671-8. 2011Through the combined efforts of the American Pathology Foundation (APF), the American Society for Clinical Pathology (ASCP), and the Program Directors Section (PRODS) of the Association of Pathology Chairs (APC), a needs assessment was ..
- Pathology archive: evaluation of integrity, regulatory compliance, and construction of searchable database from print reportsMatthew A Smith
Department of Pathology, University of Pittsburgh Medical Center, PA 15261, USA
Am J Clin Pathol 135:753-9. 2011Tissue repositories maintained by pathology departments represent an abundant resource of clinically annotated human specimens...
- Scientific and Regulatory Policy Committee (SRPC) paper: validation of digital pathology systems in the regulated nonclinical environmentRichard E Long
Charles River Laboratories, Lees Summit, MO 64082, USA
Toxicol Pathol 41:115-24. 2013Digital Pathology Systems (DPS) are dynamic, image-based computer systems that enable the acquisition, management, and interpretation of pathology information generated from digitized glass slides...
- Multi-color miniature dual-axis confocal microscope for point-of-care pathologySteven Y Leigh
Stony Brook University SUNY, Department of Biomedical Engineering, Stony Brook, NY 11794, USA
Opt Lett 37:2430-2. 2012....
- Clinical examination and validation of primary diagnosis in anatomic pathology using whole slide digital imagesDrazen M Jukic
Department of Dermatology, University of Pittsburgh School of Medicine, Pennsylvania, 15213, USA
Arch Pathol Lab Med 135:372-8. 2011Novel anatomic pathology technologies allow pathologists to digitally view and diagnose cases...
- Interdisciplinary education to integrate pathology and epidemiology: towards molecular and population-level health scienceShuji Ogino
Cancer Epidemiology Program, Dana Farber Harvard Cancer Center, 450 Brookline Ave, Room JF 215C, Boston, MA 02215, USA
Am J Epidemiol 176:659-67. 2012..We need to be open-minded and flexible in designing integrated education curricula and training programs for future students, clinicians, practitioners, and investigators...
- Teaching pathology via online digital microscopy: positive learning outcomes for rurally based medical studentsSundram Sivamalai
School of Medicine and Dentistry, James Cook University, Townsville, Queensland, Australia
Aust J Rural Health 19:45-51. 2011Technology has revolutionised teaching. Teaching pathology via digital microscopy (DM) is needed to overcome increasing student numbers, a shortage of pathology academics in regional medical schools, and difficulties with teaching ..
- Pulmonary pathology of pandemic influenza A/H1N1 virus (2009)-infected ferrets upon longitudinal evaluation by computed tomographyEdwin J B Veldhuis Kroeze
ViroClinics Biosciences B V, Rotterdam, The Netherlands
J Gen Virol 92:1854-8. 2011..CT) following infection with the 2009 pandemic A/H1N1 influenza virus and compared the scans with gross pathology, histopathology and immunohistochemistry...
- The role and impact of quantitative discovery pathologySteven J Potts
Flagship Biosciences, Flagstaff, AZ, United States
Drug Discov Today 15:943-50. 2010..information is made difficult by biological variability across organs and tissues, an insufficient pool of pathology experts working in discovery, and the high subjectivity and individual isolation of microscope-based ..
- Patterns of second-opinion diagnosis in oral and maxillofacial pathologyKyle Jones
Department of Orofacial Sciences, University of California, San Francisco, California, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109:865-9. 2010Several studies have documented the beneficial effect of second opinions in diagnostic pathology. Among disease sites, the head and neck can be a particularly problematic area for pathologists, prompting frequent second opinions...
- Personalized cancer medicine and the future of pathologyH Moch
Institute of Surgical Pathology, University Hospital Zurich, Schmelzbergstrasse 12, Zurich, Switzerland
Virchows Arch 460:3-8. 2012..from different departments in Europe met in Zurich, Switzerland, to discuss opportunities and challenges for pathology in the era of personalized medicine...
- Pathology crossword competition: an active and easy way of learning pathology in undergraduate medical educationT T Htwe
Discipline of Pathology, Universiti Kuala Lumpur Royal College of Medicine Perak, 3 Jalan Greentown, Ipoh 30450, Malaysia
Singapore Med J 53:121-3. 2012..This study aimed to determine students' performance and perception in pathology crosswords as an active way of learning and to assess their ability to memorise difficult terms in pathology.
- State-of-the-art pathology: new WHO classification, implications, and new developmentsClare H Cunliffe
Office of the Medical Investigator, University of New Mexico, 700 Camino de Salud NE, Albuquerque, NM 87106, USA
Neuroimaging Clin N Am 20:259-71. 2010..In this article, we discuss select new additions to the current classification, including new diagnostic tools, differential diagnoses, and management implications...
- Chairpersons of pathology in the United States: limited benchmarks for publicationsJohn Hedley-Whyte
Harvard University, Boston, MA 02132 4927, USA
Am J Clin Pathol 134:185-92. 2010b>Pathology chairpersons continue their preeminence in US medical schools. The Hirsch (h) index of citation was analyzed for the chairpersons of 8 specialty departments in 41 US medical schools...
- Cutting injuries in an academic pathology departmentBobbi S Pritt
Department of Pathology, Fletcher Allen Health Care, Burlington, VT 05401, USA
Arch Pathol Lab Med 129:1022-6. 2005Cutting injuries pose an infrequent but serious threat to anatomic pathology personnel. Although cut-resistant gloves may reduce this danger, it is imperative to recognize specific behaviors that increase the chance of an injury.
- Pathology services in developing countries-the West African experienceOyedele A Adeyi
Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network, Ontario, Canada
Arch Pathol Lab Med 135:183-6. 2011..To address the prevailing problems, one needs to attempt defining them...
- Clinical evaluation of the computed tomography attenuation correction map for myocardial perfusion imaging: the potential for incidental pathology detectionAndrew Tootell
Directorate of Radiography, School of Health Sciences, The University of Salford, Salford, UK
Nucl Med Commun 33:1122-6. 2012..The diagnostic potential of this data set is unclear; yet, examples exist whereby significant pathology can be identified and investigated further...
- Crossword puzzles: active learning in undergraduate pathology and medical educationAnurag Saxena
Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
Arch Pathol Lab Med 133:1457-62. 2009..new terms and concepts in a short time frame in the hematology system and the neoplasia section of the undergraduate pathology course. It is a challenge to provide adequate practice and necessary repetition to reinforce key concepts.
- The 2010 Haiti earthquake: a pathology perspective aboard the USNS ComfortSean M Hussey
Department of Pathology, National Naval Medical Center, Bethesda, Maryland 20889, USA
Arch Pathol Lab Med 135:417-21. 2011..The pathology and laboratory department staff onboard the ship helped support the mission and experienced unique mass casualty/..
- Pathology data integration with eXtensible Markup LanguageJules J Berman
Cancer Diagnosis Program, National Cancer Institute, National Institutes of Health, Bethesda, USA
Hum Pathol 36:139-45. 2005..XML, pathologists can annotate all of their data (clinical and anatomic) in a format that can transform every pathology report into a database, without compromising narrative structure...
- Image processing methods and architectures in diagnostic pathologyGloria Bueno
Engineering School, Universidad de Castilla La Mancha, Ciudad Real, Spain
Folia Histochem Cytobiol 47:691-7. 2009..describes the distributed programming system developed by the authors for virtual slide analysis in diagnostic pathology. The system supports different image analysis operations commonly done in anatomical pathology and it takes into ..
- European and US publications in the 50 highest ranking pathology journals from 2000 to 2006F R Fritzsche
Institute of Pathology, Charite Universitatsmedizin Berlin, Berlin, Germany
J Clin Pathol 61:474-81. 2008..To analyse the contributions of the 15 primary member states of the European Union and selected non-European countries to pathological research between 2000 and 2006...
- Reproducibility of immunostaining quantification and description of a new digital image processing procedure for quantitative evaluation of immunohistochemistry in pathologyVagner Bernardo
Universidade Federal Fluminense, Faculdade de Medicina, Programa de Pós Graduação em Patologia, Rua Marquês do Paraná, 303 4 andar sala 1, Hospital Universitário Antônio Pedro Centro, 24033 900, Niteroi, RJ, Brazil
Microsc Microanal 15:353-65. 2009Quantification of immunostaining is a widely used technique in pathology. Nonetheless, techniques that rely on human vision are prone to inter- and intraobserver variability, and they are tedious and time consuming...
- Optical and digital microscopic imaging techniques and applications in pathologyXiaodong Chen
College of Precision Instruments, Tianjing University, China
Anal Cell Pathol (Amst) 34:5-18. 2011..The modern digital pathology combines the power of microscopy, electronic detection, and computerized analysis...
- Basic principles and applications of fractal geometry in pathology: a reviewPranab Dey
Department of Cytology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Anal Quant Cytol Histol 27:284-90. 2005The basic principles and prospects of fractal geometry in pathology are promising. All articles found with a PubMed search with the keywords fractal dimension (FD) and related to pathology were reviewed...
- Improved learning efficiency and increased student collaboration through use of virtual microscopy in the teaching of human pathologyMark W Braun
Department of Pathology, Indiana University School of Medicine, Bloomington, Indiana, USA
Anat Sci Educ 1:240-6. 2008The implementation of virtual microscopy in the teaching of pathology at the Bloomington, Indiana extension of the Indiana University School of Medicine permitted the assessment of student attitudes, use and academic performance with ..
- Unison or cacophony: postgraduate training in pathology in EuropeFred T Bosman
Institut Universitaire de Pathologie, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 25, 1011, Lausanne CH, Switzerland
Virchows Arch 454:497-503. 2009..This is notably the case for disciplines for which shortage of well-trained staff has occurred. Pathology is among those specialties and effectively the discipline is confronted with a striking increase in mobility ..
- Pathology education in a multisite urban/rural distributed curriculumJason C Ford
Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada
Hum Pathol 39:811-6. 2008..The distribution of the pathology curriculum required meeting 3 specific challenges: (i) implementation of high-quality technologies to facilitate ..
- [Anatomic pathology workflow. IHE: modeling based on current developments in HL7 and DICOM]T Schrader
Institut fur Pathologie, Charite Universitatsmedizin Berlin, Chariteplatz 1, 10117 Berlin
Pathologe 29:308-13. 2008Consistent and complete information is essential for medical decision making. Anatomic pathology as a diagnostic discipline has a central role in the exchange of information between clinical departments throughout the diagnostic process...
- A pilot study of new approaches to teaching anatomy and pathologyA Park
University of Kentucky College of Medicine, 800 Rose Street, Lexington, Kentucky 40536 0293, USA
Surg Endosc 15:245-50. 2001..New medical education opportunities have emerged with MIS. In this pilot study we explore the role of live, interactive MIS to augment and strengthen specific segments of the undergraduate medical curriculum...
- Peer review in toxicologic pathologyJ M Ward
National Cancer Institute, Frederick, Maryland 21702 1201, USA
Toxicol Pathol 23:226-34. 1995..in safety assessment studies involving rodents and other animals is a relatively recent procedure in toxicologic pathology. It serves to ensure the integrity of the pathology evaluation in safety studies, encourages consistency of ..
- Improvements in education in pathology: virtual 3D specimensThomas Kalinski
Department of Pathology, Otto von Guericke University, Leipziger Str 44, D 39120 Magdeburg, Germany
Pathol Res Pract 205:811-4. 2009..Virtual 3D specimens expand the application of digital techniques in pathology, and will contribute significantly to the successful introduction of knowledge databases and electronic learning ..
- Best practices for reporting pathology interpretations within GLP toxicology studiesDaniel Morton
Pfizer Inc, Groton, Connecticut 06340, USA
Toxicol Pathol 34:806-9. 2006
- The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meetingR D Cardiff
U C D Center for Comparative Medicine, County Road 98 and Hutchison Drive, University of California, Davis, Davis, CA 95616, USA
Oncogene 19:968-88. 2000..Since the phenotype of the lesions is an essential component of their molecular pathology, funding agencies should adopt policies ensuring careful morphological evaluation of any funded research ..
- Digitized pathology: theory and experiences in automated tissue-based virtual diagnosisK Kayser
UICC TPCC, Institute of Pathology, Charite, University of Berlin, Germany
Rom J Morphol Embryol 47:21-8. 2006..Texture information can be derived by recursive formulas without image segmentation. Object information requires image segmentation and feature extraction. Both algorithms complete another to a "self-learning" classification system...
- Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group ReportHoward M Shulman
Department of Pathology, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, University of Washington School of Medicine, Seattle, Washington 98109, USA
Biol Blood Marrow Transplant 12:31-47. 2006..Consensus recommendations and suggested data-capture forms should be validated in prospective clinicopathologic studies...
- Evaluation of a distance-learning immunology and pathology module in a postgraduate biomedical science courseM T Ryan
Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University College Dublin, Dublin 4
Br J Biomed Sci 62:9-14. 2005An electronic presentation of materials for a distance-learning immunology and pathology module from a postgraduate biomedical science course is evaluated...
- Original research in pathology: judgment, or evidence-based medicine?James M Crawford
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0275, USA
Lab Invest 87:104-14. 2007b>Pathology is both a medical specialty and an investigative scientific discipline, concerned with understanding the essential nature of human disease...
- Computational Methods for Personalized and Adaptive Cognitive TrainingRebecca S Crowley; Fiscal Year: 2010..Work in these areas has the potential to deeply impact the fields of patient safety, medical simulation and competency- based assessment, in addition to guiding the development of future medical training systems. ..
- The ODIE Toolkit - Software for Information Extraction and Biomedical Ontology DeRebecca S Crowley; Fiscal Year: 2010..Additionally, the project would contribute to the software for developing other applications by helping researchers build more comprehensive ontologies. The results of this work may benefit both medical research and patient care. ..
- VIRTUAL SLIDEBOX OF COMPARATIVE CANCER PATHOLOGYFred Dee; Fiscal Year: 2005The long-term goal of this project is to develop a novel Virtual Slidebox of Comparative Cancer Pathology using emerging virtual slide technology as its centerpiece...
- BIOLOGY OF NEOPLASTIC TRANSFORMATION IN BREAST CANCERRobert Cardiff; Fiscal Year: 2005..The goal of this project is to develop a well-characterized model for breast cancer development and to dissect the molecular pathways involved in tumor formation. ..
- PRECLINICAL MODELS OF BREAST CANCERRobert Cardiff; Fiscal Year: 2003..The theme of the workshop is "High Throughput Phenotyping: From Mouse to Molecule in One Day!" It will allow the student to examine and compare the best and fastest phenotyping technology currently available. ..
- 25TH IABCR CONGRESS CONFERENCE: PERSONALIZED BREAST CANCER THERAPYRobert Cardiff; Fiscal Year: 2006..Following a keynote lecture from Dr. Dennis Slamon, the first session will deal with the pathology and molecular profiling of breast cancer. This session will also include a plenary lecture from Dr...
- MUTANT LINES OF ZEBRAFISH HIGHLY SENSITIVE TO NEOPLASIAJan Spitsbergen; Fiscal Year: 2005..These lines of zebrafish will provide an efficient and inexpensive system for development of new treatment and prevention strategies for cancer, and will help identify new genes controlling growth and differentiation. ..
- Competencies Training &Assessment in LaboratoryMedicine UsingPatientSimulationsFred R Dee; Fiscal Year: 2010..The simulation model and scoring key will be developed from a web-based simulation currently used in the pathology course at the University of Iowa (PathCAPS), which will be significantly upgraded in a Perl CGI scripted MySQL ..
- Novel Mechanisms of Chronic Inflammation in Sjogren's SyndromeGARY ANDREW WEISMAN; Fiscal Year: 2010..These studies should lead to better therapeutic strategies for minimizing autoimmune-associated inflammation of salivary gland that contributes to xerostomia in patients with SS. ..
- MOLECULAR TARGETS REGULATING APOPTOSISMYRTLE DAVIS; Fiscal Year: 2001..Furthermore, since these studies will be significant in the elucidation of mechanisms for induction of apoptosis, they may provide a means by which tumor cells expressing ras oncogene can be selectively targeted. ..
- Improving Patient Safety by Examining Pathology ErrorsStephen Raab; Fiscal Year: 2006..A paucity of information exists on anatomic pathology diagnostic errors and their effect on patient outcomes...
- IOWA AND MISSOURI RADON LUNG CANCER STUDIESR Field; Fiscal Year: 2007..The pooling of data between two large-scale epidemiologic studies from a similar geographic area, Iowa and Missouri, will allow us to increase sample size and statistical power. ..
- Gut Ischemia/Reperfusion Injury: Modulation by NutrientsRosemary Kozar; Fiscal Year: 2006..The sponsors are an integral part of this arrangement and are especially suited to ensure success of the proposed project...
- Integrity of the Pulmonary Blood-Gas BarrierJohn West; Fiscal Year: 2007..The identification of stress failure has clarified various aspects of human pathology such as the mechanism of high-altitude pulmonary edema, and the damage to pulmonary capillaries caused by high ..
- Biologic Studies with Peroxisome Proliferators and PPARsJanardan Reddy; Fiscal Year: 2008..The studies we now propose will generate new information, which can provide insights into the molecular complexity and the functional implications of PPAR regulated gene expression in liver. ..
- Prediction of Breast Cancer Response to Hormonal ThearpyDavid Rimm; Fiscal Year: 2007..abstract_text> ..
- RAGE and GlomerulosclerosisVIVETTE D AGATI; Fiscal Year: 2007..We propose that identification of RAGE-dependent mechanisms in glomerular diseases may lead to novel therapies to prevent, stabilize or reverse the course of chronic GS. ..
- REDUCTION OF TRIGLYCERIDES IN WOMEN ON HRTLewis Kuller; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Classification of ambiguous melanocytic tumorsBoris Bastian; Fiscal Year: 2005..In addition, this project will provide a detailed view of the aberrations found in melanocytic tumors, their prevalence and prognostic relevance. ..
- ESTABLISHMENT AND REGULATION OF CELL/CELL ADHESIONDavid Rimm; Fiscal Year: 2002..We use this tool throughout this proposal in in vitro adhesion assays and also as a unique probe for the homotypic interaction, as a mechanism to assess the co-precipitable components in the adhesion complex. ..
- FASEB Conference: Mechanisms of Liver Growth and DiseaseJanardan Reddy; Fiscal Year: 2002..abstract_text> ..
- MOLECULAR MECHANICS OF MYOSIN FILAMENTSWilliam Guilford; Fiscal Year: 2002..These data are critical to our understanding of how myosin functions at the molecular level in whole cells and tissues. ..
- PARTNERS IN HEALTH-TEACHERS, STUDENTS, PUBLIC - PHASE 2E Burns; Fiscal Year: 2002....
- NEUROCHEMICAL STUDIES ON CULTURED NEURONSLloyd Greene; Fiscal Year: 2002..work will provide insight into a wide variety of key brain functions and has the potential to lead to design of pharmaceutical agents for the treatment and prevention of a number of maladies affecting the nervous system ..
- AQUA: A New Quantitative in situ Proteomic AssayDavid Rimm; Fiscal Year: 2004..could now be translated to examination of biopsy tissue to translate the advantages of digital, continuous pathology to patient specimens...
- Hepatic engraftment of marrow cells in mice and humansNeil Theise; Fiscal Year: 2004....
- Optimal Predictors of Response to TrastuzumabDAVID L contact RIMM; Fiscal Year: 2010..Validation of the models will be done by Leave One Out Cross Validation methods in anticipation of future more robust validation in an independent cohort in a subsequent study. ..
- Transcriptional Coactivators in Liver FunctionJanardan Reddy; Fiscal Year: 2008..These studies are expected to generate new information, with implications for human impact, which could provide novel avenues for developing strategies to regulate gene function by altering coactivator activity. ..
- SEROTONIN (5-HT) RECEPTORS AND SALIVARY GLAND FUNCTIONGARY WEISMAN; Fiscal Year: 2002....
- IDENTIFICATION OF LIVER STEM CELLS IN PANCREASJanardan Reddy; Fiscal Year: 2002....
- Predicting Metastasis to Lymph NodesDavid Rimm; Fiscal Year: 2008..The technology is a new digital pathology device invented in our lab (called AQUA) that can measure protein expression in tissue samples with biochemical ..
- Transcriptional Coactivators in Liver FunctionJanardan Reddy; Fiscal Year: 2007..abstract_text> ..
- ADENOVIRAL INFECTION IN THE PATHOGENESIS OF EMPHYSEMAJames Hogg; Fiscal Year: 2003..The information gathered from these studies will provide new insights into the pathogenesis of emphysema and help explain why some smokers develop emphysema and others do not. ..
- PATHOLOGY OF THE LABORATORY MOUSEJohn Sundberg; Fiscal Year: 2006..Likewise, veterinary pathologists, although used to working with many species, have little or no human pathology experience and often little or no mouse pathology expertise...
- RESEARCH TRAINING FOR VETERINARIANS: ANIMAL MODELSJohn Sundberg; Fiscal Year: 2008..Veterinarians have few opportunities to be trained in comparative pathology, molecular biology, and model development using inbred and genetically engineered laboratory mice...
- PATHOLOGIC ASSESSMENT OF LUNG VOLUME REDUCTION SURGERYJames Hogg; Fiscal Year: 2002..The results of this study will provide definite criteria useful in selecting the patients that will receive the greatest benefit from lung volume reduction surgery. ..
- Alopecia and Ulcerative Dermatitis in B6 MiceJohn Sundberg; Fiscal Year: 2007..Future work will apply findings to human patients to either modify lifestyle or more appropriately treat CCCA to reduce suffering and disfiguration. [unreadable] [unreadable] [unreadable]..