sequence homology

Summary

Summary: The degree of similarity between sequences. Studies of AMINO ACID SEQUENCE HOMOLOGY and NUCLEIC ACID SEQUENCE HOMOLOGY provide useful information about the genetic relatedness of genes, gene products, and species.

Top Publications

  1. pmc Use of sequence analysis of the NS5B region for routine genotyping of hepatitis C virus with reference to C/E1 and 5' untranslated region sequences
    Donald G Murphy
    Laboratoire de sante publique du Quebec, Institut National de Sante Publique du Quebec, 20045 Chemin Sainte Marie, Sainte Anne de Bellevue H9X 3R5, Quebec, Canada
    J Clin Microbiol 45:1102-12. 2007
  2. pmc Phylogenetic analysis of deformed wing virus genotypes from diverse geographic origins indicates recent global distribution of the virus
    Olga Berényi
    Zoonoses and Emerging Infections Group, Clinical Virology, Clinical Department of Diagnostic Imaging, Infectious Diseases and Clinical Pathology, University of Veterinary Medicine, Vienna, A 1210 Vienna, Austria
    Appl Environ Microbiol 73:3605-11. 2007
  3. ncbi New avian influenza A virus subtype combination H5N7 identified in Danish mallard ducks
    K Bragstad
    Department of Virology, Statens Serum Institut, 5 Artillerivej, DK 2300 Copenhagen S, Denmark
    Virus Res 109:181-90. 2005
  4. ncbi A subgroup of MYB transcription factor genes undergoes highly conserved alternative splicing in Arabidopsis and rice
    Jigang Li
    Peking Yale Joint Center for Plant Molecular Genetics and Agro Biotechnology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, PR China
    J Exp Bot 57:1263-73. 2006
  5. doi HadA is an atypical new multifunctional trimeric coiled-coil adhesin of Haemophilus influenzae biogroup aegyptius, which promotes entry into host cells
    Davide Serruto
    Research Center, Novartis Vaccines and Diagnostics, Siena, Italy
    Cell Microbiol 11:1044-63. 2009
  6. pmc Quantifying similarity between motifs
    Shobhit Gupta
    Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Box 355065, Seattle, WA 98195, USA
    Genome Biol 8:R24. 2007
  7. pmc Molecular characterization of Chikungunya virus isolates from clinical samples and adult Aedes albopictus mosquitoes emerged from larvae from Kerala, South India
    Kudukkil P Niyas
    Molecular Virology Laboratory, Rajiv Gandhi Centre for Biotechnology RGCB, Thycaud P O, Thiruvananthapuram 695014, Kerala, India
    Virol J 7:189. 2010
  8. ncbi Automatic clustering of orthologs and in-paralogs from pairwise species comparisons
    M Remm
    Center for Genomics and Bioinformatics, Karolinska Institutet, S-17177 Stockholm, Sweden
    J Mol Biol 314:1041-52. 2001
  9. doi Re-examining the phylogeny of clinically relevant Candida species and allied genera based on multigene analyses
    Clement K M Tsui
    Molecular Mycology Research Laboratory, Center for Infectious Diseases and Microbiology, Westmead Hospital, Westmead Millennium Institute, Westmead, NSW, Australia
    FEMS Yeast Res 8:651-9. 2008
  10. pmc Evolutionary processes among sylvatic dengue type 2 viruses
    Nikos Vasilakis
    Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    J Virol 81:9591-5. 2007

Detail Information

Publications268 found, 100 shown here

  1. pmc Use of sequence analysis of the NS5B region for routine genotyping of hepatitis C virus with reference to C/E1 and 5' untranslated region sequences
    Donald G Murphy
    Laboratoire de sante publique du Quebec, Institut National de Sante Publique du Quebec, 20045 Chemin Sainte Marie, Sainte Anne de Bellevue H9X 3R5, Quebec, Canada
    J Clin Microbiol 45:1102-12. 2007
    ..Our results show that genotyping of HCV by nucleotide sequence analysis of NS5B is efficient, allows the accurate discrimination of subtypes, and is an effective tool for studying the molecular epidemiology of HCV...
  2. pmc Phylogenetic analysis of deformed wing virus genotypes from diverse geographic origins indicates recent global distribution of the virus
    Olga Berényi
    Zoonoses and Emerging Infections Group, Clinical Virology, Clinical Department of Diagnostic Imaging, Infectious Diseases and Clinical Pathology, University of Veterinary Medicine, Vienna, A 1210 Vienna, Austria
    Appl Environ Microbiol 73:3605-11. 2007
    ..Due to the high level of sequence conservation, no significant clustering of the samples in the phylogenetic trees could be identified. On the other hand, the phylogenetic analyses support a genetic segregation of KGV and VDV-1 from DWV...
  3. ncbi New avian influenza A virus subtype combination H5N7 identified in Danish mallard ducks
    K Bragstad
    Department of Virology, Statens Serum Institut, 5 Artillerivej, DK 2300 Copenhagen S, Denmark
    Virus Res 109:181-90. 2005
    ..To our knowledge this is the first report of an H5N7 influenza A virus...
  4. ncbi A subgroup of MYB transcription factor genes undergoes highly conserved alternative splicing in Arabidopsis and rice
    Jigang Li
    Peking Yale Joint Center for Plant Molecular Genetics and Agro Biotechnology, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, PR China
    J Exp Bot 57:1263-73. 2006
    ..These data suggest that this subgroup of transcription factor genes may be involved in multiple biological processes and may be transcriptionally regulated by alternative splicing...
  5. doi HadA is an atypical new multifunctional trimeric coiled-coil adhesin of Haemophilus influenzae biogroup aegyptius, which promotes entry into host cells
    Davide Serruto
    Research Center, Novartis Vaccines and Diagnostics, Siena, Italy
    Cell Microbiol 11:1044-63. 2009
    ..These data give new insights on the structure-function relationship of oligomeric coiled-coil adhesins and suggest a potential role of this protein in the pathogenesis of BPF...
  6. pmc Quantifying similarity between motifs
    Shobhit Gupta
    Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Box 355065, Seattle, WA 98195, USA
    Genome Biol 8:R24. 2007
    ..Experimental simulations demonstrate the accuracy of Tomtom's E values and its effectiveness in finding similar motifs...
  7. pmc Molecular characterization of Chikungunya virus isolates from clinical samples and adult Aedes albopictus mosquitoes emerged from larvae from Kerala, South India
    Kudukkil P Niyas
    Molecular Virology Laboratory, Rajiv Gandhi Centre for Biotechnology RGCB, Thycaud P O, Thiruvananthapuram 695014, Kerala, India
    Virol J 7:189. 2010
    ..Detection of virus in adult mosquitoes, emerged in the laboratory from larvae, also points to the possibility of transovarial transmission (TOT) of mutant CHIKV strains in mosquitoes...
  8. ncbi Automatic clustering of orthologs and in-paralogs from pairwise species comparisons
    M Remm
    Center for Genomics and Bioinformatics, Karolinska Institutet, S-17177 Stockholm, Sweden
    J Mol Biol 314:1041-52. 2001
    ..cgb.ki.se/inparanoid/. This is the first comprehensive resource with orthologs of all fully sequenced eukaryotic genomes. Programs and tables of orthology assignments are available from the same location...
  9. doi Re-examining the phylogeny of clinically relevant Candida species and allied genera based on multigene analyses
    Clement K M Tsui
    Molecular Mycology Research Laboratory, Center for Infectious Diseases and Microbiology, Westmead Hospital, Westmead Millennium Institute, Westmead, NSW, Australia
    FEMS Yeast Res 8:651-9. 2008
    ..Pichia fermentans and other environmental species are concentrated in Group D. Group E, containing Pichia anomala, may be a sibling to group F, which is represented by the Saccharomyces species complex...
  10. pmc Evolutionary processes among sylvatic dengue type 2 viruses
    Nikos Vasilakis
    Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555 0609, USA
    J Virol 81:9591-5. 2007
    ..Our findings support a recent cross-species transmission event and suggest the possibility of future DENV reemergence from the sylvatic cycle...
  11. pmc Origin and evolution of HIV-1 in breast milk determined by single-genome amplification and sequencing
    Jesus F Salazar-Gonzalez
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, E CLS1028, Boston, MA 02115, USA
    J Virol 85:2751-63. 2011
    ....
  12. ncbi Global distribution of nearly identical phage-encoded DNA sequences
    Mya Breitbart
    Department of Biology, LS301, Center for Microbial Sciences, San Diego State University, 5500 Campanile Drive, LS301, San Diego, CA 92182 4614, USA
    FEMS Microbiol Lett 236:249-56. 2004
    ....
  13. ncbi Molecular cloning and expression profile of putative antilipopolysaccharide factor in Chinese shrimp(Fenneropenaeus chinensis)
    Fengsong Liu
    Experimental Marine Biology Laboratory, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
    Mar Biotechnol (NY) 7:600-8. 2005
    ..Significant enhancement of ALFFc transcription appeared during the first 24 hours in response to Vibrio infection. These results provide useful information for understanding the function of ALFFc in shrimp...
  14. ncbi Snake venom fibrin(ogen)olytic enzymes
    S Swenson
    Department of Biochemistry and Molecular Biology, Norris Comprehensive Cancer Centre, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Toxicon 45:1021-39. 2005
    ....
  15. pmc Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase
    Chien Hua Pai
    Institute of Biological Chemistry, Academia Sinica, No 128 Academia Road Section 2, Nan Kang, Taipei 11529, Taiwan
    EMBO J 25:5970-82. 2006
    ..Our results constitute the first structural information on the biochemical features of parasite homologs (including TryS) that underlie their broad specificity for polyamines...
  16. pmc Identification, characterization and antigenicity of the Plasmodium vivax rhoptry neck protein 1 (PvRON1)
    Darwin A Moreno-Perez
    Fundacion Instituto de Inmunologia de Colombia, Carrera 50 No, 26 20, Bogota, Colombia
    Malar J 10:314. 2011
    ..This study describes the identification and characterization of the P. vivax rhoptry neck protein 1 (PvRON1) and examine its antigenicity in natural P. vivax infections...
  17. pmc Comparative investigation of the genomic regions involved in antigenic variation of the TprK antigen among treponemal species, subspecies, and strains
    Lorenzo Giacani
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Bacteriol 194:4208-25. 2012
    ....
  18. ncbi ESyPred3D: Prediction of proteins 3D structures
    Christophe Lambert
    Facultes Universitaires Notre Dame de la Paix, Unité de Recherche en Biologie Moléculaire, rue de Bruxelles, 61, B 5000 Namur, Belgium
    Bioinformatics 18:1250-6. 2002
    ..The target-template alignment step is generally accepted as the most critical step in homology modeling...
  19. ncbi Genetic characterization of a porcine H1N2 influenza virus strain isolated in Germany
    Christine Schrader
    Federal Institute for Health Protection of Consumers and Veterinary Medicine, Berlin, Germany
    Intervirology 46:66-70. 2003
    ..It is a result of a multiple reassortment event...
  20. ncbi Biological evaluation of d2, an algorithm for high-performance sequence comparison
    W Hide
    Department of Biochemical and Biophysical Sciences, University of Houston, TX 77204 5934, USA
    J Comput Biol 1:199-215. 1994
    ..This work demonstrates that d2 is a unique, sensitive, and selective method of rapid sequence comparison that can detect novel sequence relationships which remain undetected by alternate methodologies...
  21. pmc Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants
    M R Abrahams
    Institute of Infectious Diseases and Molecular Medicine, Division of Medical Virology, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa
    J Virol 83:3556-67. 2009
    ....
  22. pmc Protein and DNA sequence determinants of thermophilic adaptation
    Konstantin B Zeldovich
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America
    PLoS Comput Biol 3:e5. 2007
    ..Together these results provide a complete picture of how compositions of proteomes and genomes in prokaryotes adjust to the extreme conditions of the environment...
  23. ncbi Gene expression in haemocytes of kuruma prawn, Penaeus japonicus, in response to infection with WSSV by EST approach
    Jiraporn Rojtinnakorn
    Department of Aquatic Biosciences, Tokyo University of Fisheries, Japan
    Fish Shellfish Immunol 13:69-83. 2002
    ..Those encoding for apoptotic peptides were expressed at high levels in infected library. The putative defence proteins accounted for 2.7% of total ESTs in a normal shrimp library and 15.7% of the total ESTs in an infected library...
  24. pmc Genomewide screening reveals high levels of insertional polymorphism in the human endogenous retrovirus family HERV-K(HML2): implications for present-day activity
    Robert Belshaw
    Department of Biological Sciences, Imperial College, Ascot, Berks, United Kingdom
    J Virol 79:12507-14. 2005
    ..This view of the family from a population perspective rather than a genome perspective will inform the current debate about a possible role of HERV-K(HML2) in human disease...
  25. pmc Complete genome sequence of a highly divergent astrovirus isolated from a child with acute diarrhea
    Stacy R Finkbeiner
    Departments of Molecular Microbiology and Pathology and Immunology, Washington University School of Medicine, St, Louis, MO, USA
    Virol J 5:117. 2008
    ..We have previously described the identification of several sequence fragments with limited sequence identity to known astroviruses in a stool specimen obtained from a child with acute diarrhea, suggesting that a novel virus was present...
  26. ncbi Molecular characterization of a novel simian immunodeficiency virus lineage (SIVtal) from northern talapoins (Miopithecus ogouensis)
    Florian Liegeois
    UMR145, Institut de Recherche pour le Developpement, University of Montpellier I, Montpellier, France
    Virology 349:55-65. 2006
    ..Although northern talapoins belong to the Miopithecus genus, their SIVs belong to the Cercopithecus SIV lineage, suggesting evolution from a common ancestor or cross-species transmission between both primate genera...
  27. pmc HomPPI: a class of sequence homology based protein-protein interface prediction methods
    Li C Xue
    Department of Computer Science, Iowa State University, Ames, IA 50011, USA
    BMC Bioinformatics 12:244. 2011
    ....
  28. pmc Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencing
    Jesus F Salazar-Gonzalez
    Department of Medicine, University of Alabama at Birmingham, 720 20th Street South, Kaul 816, Birmingham, AL 35294, USA
    J Virol 82:3952-70. 2008
    ....
  29. pmc Phylogenetic analysis and characterization of Korean orf virus from dairy goats: case report
    Jae Ku Oem
    Animal Disease Diagnostic Center, National Veterinary Research and Quarantine Service, 480 Anyang 6 dong, Anyang, 430 824, Republic of Korea
    Virol J 6:167. 2009
    ..Phylogenetic analysis revealed that the ORF/09/Korea strain was closest to the isolates (Taiping) from Taiwan. This is believed to be the first report on the molecular characterization of orf virus in Korea...
  30. doi Complete genome characterisation of a Newcastle disease virus isolated during an outbreak in Sweden in 1997
    Anna Malin Linde
    Department of Biomedical Sciences and Veterinary Public Health, Section of Virology, Swedish University of Agricultural Sciences SLU, Ulls Väg 2B, Uppsala, Sweden
    Virus Genes 41:165-73. 2010
    ..It had a length of 15,192 bases and consisted of six genes in the order 3'-NP-P-M-F-HN-L-5'. The F protein cleavage site was 112-RRQRRF-117, corresponding to that of a virulent pathotype...
  31. pmc Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B
    Friederike Flachsbart
    Institute of Clinical Molecular Biology, Christian Albrechts University, Schittenhelmstrasse 12, Kiel, Germany
    Eur J Hum Genet 21:240-2. 2013
    ..FOXO3A), a validated human longevity gene, is greatly hampered by the fact that its exonic regions have 99% sequence homology with the FOXO3B pseudogene...
  32. pmc Effect of nutrient restriction and re-feeding on calpain family genes in skeletal muscle of channel catfish (Ictalurus punctatus)
    Elena Preziosa
    Fish Molecular Genetics and Biotechnology Laboratory, Department of Fisheries and Allied Aquacultures and Program of Cell and Molecular Biosciences, Aquatic Genomics Unit, Auburn University, Alabama, United States of America
    PLoS ONE 8:e59404. 2013
    ..Calpains are generated as inactive proenzymes which are activated by N-terminal autolysis induced by calcium-ions...
  33. pmc Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species
    Fumihiko Takeuchi
    Department of Microbiology and Infection Control Science, Juntendo University, Tokyo, Japan
    J Bacteriol 187:7292-308. 2005
    ..Such rearrangements could have brought genomic plasticity to this species and contributed to its acquisition of antibiotic resistance...
  34. ncbi Assigning new GO annotations to protein data bank sequences by combining structure and sequence homology
    Julia V Ponomarenko
    San Diego Supercomputer Center, University of California, San Diego, La Jolla, California 92093 0537, USA
    Proteins 58:855-65. 2005
    ..large number of protein sequences based on direct experimental evidence and through inference determined by sequence homology. Here we show that this annotation can be extended and corrected for cases where protein structures are ..
  35. pmc Cyclic coordinate descent: A robotics algorithm for protein loop closure
    Adrian A Canutescu
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Protein Sci 12:963-72. 2003
    ..It succeeds in closing loops in a large test set 99.79% of the time, and fails occasionally only for short, highly extended loops. It is very fast, closing loops of length 8 in 0.037 sec on average...
  36. pmc The SH3/PH domain protein AgBoi1/2 collaborates with the Rho-type GTPase AgRho3 to prevent nonpolar growth at hyphal tips of Ashbya gossypii
    Philipp Knechtle
    Molecular Microbiology, Biozentrum der Universitat Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Eukaryot Cell 5:1635-47. 2006
    ..We conclude that AgBoi1/2p and AgRho3p support polarisome-mediated actin cable formation at hyphal tips, thereby ensuring permanent polar tip growth...
  37. ncbi Making connections: cholinesterase-domain proteins in the CNS
    Francisco G Scholl
    Columbia University, Department of Physiology and Cellular Biophysics, and Center for Neurobiology and Behavior, College of Physicians and Surgeons, 630 West 168th Street, P and S 11 511, New York, NY 10032, USA
    Trends Neurosci 26:618-24. 2003
    ..Members of this protein family are characterized by an extracellular domain with sequence homology to cholinesterases and include the neuroligins, synaptic cell adhesion molecules recently implicated in ..
  38. doi Acute hepatitis A virus infection in Turkey
    Andrea Normann
    University of Tubingen, Children s Hospital, Tubingen, Germany
    J Med Virol 80:785-90. 2008
    ..No evidence was found for an association between viral load and the higher transaminase levels in the younger group...
  39. ncbi A five-gene phylogeny of Pezizomycotina
    Joseph W Spatafora
    Department of Botany and Plant Pathology, Oregon State University, Corvallis 97331, USA
    Mycologia 98:1018-28. 2006
    ..Within Leotiomyceta, the supraclass clades of Leotiomycetes s.s. plus Sordariomycetes and Arthoniomycetes plus Dothideomycetes were resolved with moderate support...
  40. ncbi Esterases from Bacillus subtilis and B. stearothermophilus share high sequence homology but differ substantially in their properties
    E Henke
    Institute of Chemistry and Biochemistry, Department of Technical Chemistry and Biotechnology, Greifswald University, Soldmannstrasse 16, 17487 Greifswald, Germany
    Appl Microbiol Biotechnol 60:320-6. 2002
    ..In contrast, BsubE converted 1-phenethylacetate with higher selectivity ( E>150 vs E=8)...
  41. ncbi Alignment-free sequence comparison-a review
    Susana Vinga
    Department of Biometry and Epidemiology, Medical University of South Carolina, 135 Cannon Street, Suite 303, PO Box 250835, Charleston, SC 29425, USA
    Bioinformatics 19:513-23. 2003
    ..The formulation of alternative metrics for dissimilarity between sequences and their algorithmic implementations are reviewed...
  42. pmc Near full-length genome analysis of low prevalent human immunodeficiency virus type 1 subclade F1 in São Paulo, Brazil
    Sabri Saeed Sanabani
    Fundação Pró Sangue, Hemocentro, Sao Paulo, Brazil
    Virol J 6:78. 2009
    ..In this study we aimed to characterize and define the molecular prevalence of HIV-1 subclade F1 currently circulating in São Paulo, Brazil...
  43. doi Alpha2-macroglobulin from an Atlantic shrimp: biochemical characterization, sub-cellular localization and gene expression upon fungal challenge
    Luciane Maria Perazzolo
    Laboratório de Imunologia Aplicada a Aquicultura, Departamento de Biologia Celular, Embriologia e Genética BEG, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina UFSC, CEP 88040 900, Florianopolis, SC, Brazil
    Fish Shellfish Immunol 31:938-43. 2011
    ..This is the first report on a α2M characterization in an Atlantic penaeid species and its expression profile upon a fungal infection...
  44. pmc Characterization of a mycovirus associated with the brown discoloration of edible mushroom, Flammulina velutipes
    Yumi Magae
    Department of Applied Microbiology, Forestry and Forest Products Research Institute, Tsukuba, Ibaraki 305 8687, Japan
    Virol J 7:342. 2010
    ..A mycovirus previously identified in brown discolored fruiting bodies of the cultivated mushroom Flammulina velutipes was characterized. We tentatively named the virus the F. velutipes browning virus (FvBV)...
  45. ncbi Antiretroviral drug resistance and phylogenetic diversity of HIV-1 in Chile
    Maritza Ríos
    Centro Nacional de Referencia de VIH SIDA, Instituto de Salud Publica de Chile, Santiago, Chile
    J Med Virol 79:647-56. 2007
    ..Additionally, phylogenetic analysis of the PR-RT coding sequences reveals the presence of BF intersubtype recombinants...
  46. ncbi ConSurf: an algorithmic tool for the identification of functional regions in proteins by surface mapping of phylogenetic information
    A Armon
    Department of Biochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel
    J Mol Biol 307:447-63. 2001
    ..A computer program that implements these ideas is available freely at: http://ashtoret.tau.ac.il/ approximately rony..
  47. pmc Temporal modulation of an autoprotease is crucial for replication and pathogenicity of an RNA virus
    T Lackner
    Institut für Virologie FB Veterinärmedizin, Justus Liebig Universitat Giessen, Frankfurter Strasse 107, 35392 Giessen, Germany
    J Virol 78:10765-75. 2004
    ..The biotype-specific modulation of NS2-3 autoprocessing indicates a crucial role of the NS2 autoprotease in the pathogenicity of BVDV...
  48. pmc Tissue-specific transcriptional regulation has diverged significantly between human and mouse
    Duncan T Odom
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:730-2. 2007
    ..When the same protein binds the promoters of orthologous genes, approximately two-thirds of the binding sites do not align...
  49. pmc Novel mammalian herpesviruses and lineages within the Gammaherpesvirinae: cospeciation and interspecies transfer
    Bernhard Ehlers
    P14 Molekulare Genetik und Epidemiologie von Herpesviren, Robert Koch Institut, D 13353 Berlin, Germany
    J Virol 82:3509-16. 2008
    ..The tree's branching pattern can be interpreted only in part in terms of the cospeciation of virus and host lineages, and a substantial incidence of the interspecies transfer of viruses must also be invoked...
  50. ncbi The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis
    Tomoya S Kitajima
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Hongo, Tokyo 113 0033, Japan
    Nature 427:510-7. 2004
    ..These findings provide insights into the evolution of meiosis and kinetochore regulation during mitosis and meiosis...
  51. ncbi Pocketome via comprehensive identification and classification of ligand binding envelopes
    Jianghong An
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Mol Cell Proteomics 4:752-61. 2005
    ..The pocketome can be used for rapid evaluation of possible binding partners of a given chemical compound...
  52. ncbi Complete genome analysis and molecular characterization of Usutu virus that emerged in Austria in 2001: comparison with the South African strain SAAR-1776 and other flaviviruses
    Tamas Bakonyi
    Zoonoses and Emerging Infections Group, Clinical Virology, Clinical Department of Diagnostics, University of Veterinary Medicine, Vienna, A 1210 Vienna, Austria
    Virology 328:301-10. 2004
    ..The factors that determine the severe clinical symptoms caused by the Austrian USUV strain in Eurasian blackbirds are discussed. We also offer a possible explanation for the origins and dispersal of USUV, JEV, and MVEV out of Africa...
  53. pmc Dengue virus serotype 2 from a sylvatic lineage isolated from a patient with dengue hemorrhagic fever
    Jane Cardosa
    Institute of Health and Community Medicine, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak, Malaysia
    PLoS Negl Trop Dis 3:e423. 2009
    ..This is the first identification of a sylvatic DENV circulating in Asia since 1975...
  54. doi Detection of a novel porcine boca-like virus in the background of porcine circovirus type 2 induced postweaning multisystemic wasting syndrome
    Anne Lie Blomström
    Department of Biomedical Sciences and Veterinary Public Health, Division of Microbiology and Food Safety, Swedish University of Agricultural Sciences, S 750 07 Uppsala, Sweden
    Virus Res 146:125-9. 2009
    ..By comparative analysis of the nucleotide sequences and phylogenetic studies we propose that this is a novel porcine parvovirus, with genetic relationship to bocaviruses...
  55. doi Detection and description of a particular Ostreid herpesvirus 1 genotype associated with massive mortality outbreaks of Pacific oysters, Crassostrea gigas, in France in 2008
    Amélie Segarra
    Institut Français de Recherche pour l Exploitation de la Mer IFREMER, Laboratoire de Génétique et Pathologie LGP, avenue de Mus de Loup, 17390 La Tremblade, France
    Virus Res 153:92-9. 2010
    ..The analyses of 76 sequences showed OsHV-1 microVar detection only in 2008 isolates. These data suggest that OsHV-1 microVar can be assumed as an emergent genotype...
  56. ncbi Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog
    C C Thompson
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    J Neurosci 16:7832-40. 1996
    ..Srg1 and hr are likely part of a cascade of gene activation induced by thyroid hormone that is critical for CNS organization and development...
  57. doi Evidence of diversification of dengue virus type 3 genotype III in the South American region
    Domenica de Mora
    Instituto Nacional de Higiene y Medicina Tropical Leopoldo Inquieta Perez, Julian Coronel y Esmeraldas, Guayaquil, Ecuador
    Arch Virol 154:699-707. 2009
    ..At least six different genotype III clades were observed. Amino acids substitutions were found in domain III E protein neutralization epitopes and in surface-exposed domain II and III E protein amino acid sequences...
  58. doi Molecular epidemiology of current classical swine fever virus isolates of wild boar in Germany
    Immanuel Leifer
    Institute of Diagnostic Virology, Friedrich Loeffler Institut, Südufer 10, D 17493 Greifswald Insel Riems, Germany
    J Gen Virol 91:2687-97. 2010
    ..Hence, regional persistence in wild boar populations has to be taken into account as an important factor in the continual outbreaks in affected areas...
  59. pmc Structural similarity in the absence of sequence homology of the messenger RNA export factors Mtr2 and p15
    Sebastien Fribourg
    European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    EMBO Rep 4:699-703. 2003
    ..In addition, Mtr2 presents a long internal loop, which contains residues that affect the export of the large ribosomal subunit...
  60. ncbi The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene)
    T J Mariani
    Dept of Surgery, UMDNJ Robert Wood Johnson Medical School, New Brunswick 08903
    Matrix 12:242-8. 1992
    ..8 kb, 3.8 kb and 2.0 kb. In addition, using a panel of human mouse cell hybrids, the lysyl oxidase gene was assigned to human chromosome 5...
  61. pmc HIV-1 recombinants with multiple parental strains in low-prevalence, remote regions of Cameroon: evolutionary relics?
    Jean K Carr
    Institute of Human Virology, Univ, of Maryland School of Medicine, Baltimore, MD, USA
    Retrovirology 7:39. 2010
    ..Partial pol amplicons (N = 164) and nearly full virus genomes (N = 78) were sequenced. Among the 3956 rural villagers studied, the prevalence of HIV infection was 4.9%; among the hospitalized and clinic patients, it was 8.6%...
  62. ncbi Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity
    Lee Rowen
    Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington 98103, USA
    Genomics 79:587-97. 2002
    ..The sequences of these genes provide insight into the mechanisms used to generate the diversity of neurexin protein isoforms and raise several interesting questions regarding the expression mechanism of large genes...
  63. pmc Plasmodium falciparum homologue of the genes for Plasmodium vivax and Plasmodium yoelii adhesive proteins, which is transcribed but not translated
    H M Taylor
    National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    Infect Immun 69:3635-45. 2001
    ..falciparum (PfRH3) that is transcribed in its entirety, under stage-specific control, with correct splicing of the intron, but appears not to be translated, probably due to two reading frameshifts at the 5' end of the gene...
  64. pmc Emergence of Usutu virus in Hungary
    Tamas Bakonyi
    Department of Microbiology and Infectious Diseases, Faculty of Veterinary Science, Szent Istvan University, Hungária krt 23 25, H 1143, Budapest, Hungary
    J Clin Microbiol 45:3870-4. 2007
    ..This result indicates that the USUV strain responsible for the blackbird die-off in Budapest most likely spread from Austria to Hungary instead of being independently introduced from Africa...
  65. pmc Recombination in West Nile Virus: minimal contribution to genomic diversity
    Brett E Pickett
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294 2170, USA
    Virol J 6:165. 2009
    ..This one isolated recombinant genome was out of a total of 154 sequences analyzed. It therefore does not seem likely that recombination contributes in any significant manner to the overall sequence variation within the WNV genome...
  66. ncbi Complete nucleotide sequence of a Chinese serotype Asia1 vaccine strain of foot-and-mouth disease virus
    Junzheng Du
    Key Laboratory of Animal Virology of the Ministry of Agriculture, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China
    Virus Genes 35:635-42. 2007
    ..This study is the first description of the full-length genomic sequence of FMDV Chinese serotype Asia1...
  67. pmc Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis
    Randolph B Caldwell
    Institute of Molecular Radiobiology, GSF, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Genome Biol 6:R6. 2005
    ..This resource defines the structure and the coding potential of a large fraction of B-cell specific and housekeeping genes whose function can be analyzed by disruption in the chicken DT40 B-cell line...
  68. pmc A horizontal gene transfer event defines two distinct groups within Burkholderia pseudomallei that have dissimilar geographic distributions
    Apichai Tuanyok
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    J Bacteriol 189:9044-9. 2007
    ..In addition, clinical isolates are more likely to belong to group YLF, whereas environmental isolates are more likely to belong to group BTFC. These groups should be further characterized in an animal model...
  69. pmc Phylogenetic analysis of Newcastle disease viruses isolated from waterfowl in the upper midwest region of the United States
    Naresh Jindal
    Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, 1333 Gortner Avenue, Saint Paul, MN, 55108, USA
    Virol J 6:191. 2009
    ..Partial sequences of fusion gene were analyzed to determine the pathotypes and genotypes involved...
  70. doi Complete genome sequence of a virulent Newcastle disease virus isolated from an outbreak in chickens in Egypt
    Mahmoud H A Mohamed
    Virginia Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
    Virus Genes 39:234-7. 2009
    ..Determination of complete genome sequences of additional NDV strains from Africa is necessary to understand the epidemiology of currently circulating viruses in Africa...
  71. doi Gene repertoire of amoeba-associated giant viruses
    Philippe Colson
    URMITE UMR CNRS 6236 IRD 198, Facultes de Medecine et de Pharmacie, Universite de la Mediterranee, Marseille, France
    Intervirology 53:330-43. 2010
    ..Altogether, the data so far accumulated on amoeba-associated giant viruses are a powerful incentive to isolate and study additional strains to gain better understanding of their pangenome...
  72. doi Novel parvovirus sublineage in the family of Parvoviridae
    Fang Wang
    Key Lab of Animal Epidemic Etiology and Immunological Prevention of MOA, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, People s Republic of China
    Virus Genes 41:305-8. 2010
    ..Based on these results, we propose a novel parvovirus sublineage, Cnvirus, to describe these parvoviruses...
  73. doi Molecular characterization of a Ran isoform gene up-regulated in shrimp immunity
    Fang Han
    College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China
    Gene 495:65-71. 2012
    ..8 times (at 6h) as much as that in the control in the hepatopancreas challenged by WSSV. This investigation might provide a clue to elucidate the shrimp innate immunity and would be helpful to shrimp disease control...
  74. ncbi The genome of model malaria parasites, and comparative genomics
    Jane Carlton
    The Institute for Genomic Research, Rockville, MD 20850, USA
    Curr Issues Mol Biol 7:23-37. 2005
    ..This is a stimulating time for comparative genomics of model and human malaria parasites, which promises to produce useful results for the development of antimalarial drugs and vaccines...
  75. pmc The genome sequence of avian pathogenic Escherichia coli strain O1:K1:H7 shares strong similarities with human extraintestinal pathogenic E. coli genomes
    Timothy J Johnson
    Department of Veterinary Microbiology and Preventive Medicine, College of Veterinary Medicine, 1802 Elwood Drive, VMRI 2, Iowa State University, Ames, IA 50011, USA
    J Bacteriol 189:3228-36. 2007
    ..Future studies are necessary to assess the ability of APEC to overcome the hurdles necessary for such a food-borne transmission, and epidemiological studies are required to confirm that such a phenomenon actually occurs...
  76. ncbi Serological and molecular characteristics of Vibrio vulnificus biotype 3: evidence for high clonality
    Naiel Bisharat
    Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel
    Microbiology 153:847-56. 2007
    ..vulnificus...
  77. doi Comparative full genome analysis revealed E1: A226V shift in 2007 Indian Chikungunya virus isolates
    S R Santhosh
    Division of Virology, Defence R and D Establishment, Gwalior, MP, India
    Virus Res 135:36-41. 2008
    ....
  78. pmc Computational analysis of human adenovirus type 22 provides evidence for recombination among species D human adenoviruses in the penton base gene
    Christopher M Robinson
    Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Virol 83:8980-5. 2009
    ..Further study of recombination among HAdVs is needed to better predict possible recombination events among wild-type viruses and adenoviral gene therapy vectors...
  79. doi Molecular characterization of the E gene of dengue virus type 1 isolated in Guangdong province, China, in 2006
    K Zheng
    Center for Diseases Control and Prevention of Guangdong province, Guangzhou, PR China
    Epidemiol Infect 137:73-8. 2009
    ..In contrast, one isolate from Guangzhou city in 2006, may have been introduced by a recently imported case from Cambodia...
  80. pmc Crossing over between regions of limited homology in Escherichia coli. RecA-dependent and RecA-independent pathways
    Susan T Lovett
    Rosenstiel Basic Medical Sciences Research Center and the Department of Biology, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    Genetics 160:851-9. 2002
    ..Levels of crossing over were increased by defects in DnaB helicase and by oxidative damage, showing that damaged DNA or stalled replication can initiate genetic recombination...
  81. ncbi Eimeria tenella: identification of secretory and surface proteins from expressed sequence tags
    Christian Klotz
    Department of Molecular Parasitology, Humboldt University, Berlin, Germany
    Exp Parasitol 111:14-23. 2005
    ..For five selected candidate proteins we found that these were indeed secreted. Our approach thus represents an efficient method to identify secretory and surface proteins out of EST databases...
  82. ncbi Identifying cycling genes by combining sequence homology and expression data
    Yong Lu
    School of Computer Science, Carnegie Mellon University, 5000 Forbes Ave, Pittsburgh, PA, 15213, USA
    Bioinformatics 22:e314-22. 2006
    ..Due to noise and other data analysis problems, accurately deriving a set of cycling genes from expression data is a hard problem. This is especially true for some of the multicellular organisms, including humans...
  83. pmc The TIGR rice genome annotation resource: annotating the rice genome and creating resources for plant biologists
    Qiaoping Yuan
    The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
    Nucleic Acids Res 31:229-33. 2003
    ..All of the data is available through web-based interfaces, FTP downloads, and a Distributed Annotation System...
  84. ncbi Analysis and comparison of the 4b core protein gene of avipoxviruses from wild birds: evidence for interspecies spatial phylogenetic variation
    S C Weli
    Department of Microbiology and Virology, University of Tromsø, Tromsø, Norway
    Arch Virol 149:2035-46. 2004
    ..6%, 81%, 81%, 64.8% and 84.5%, respectively. Furthermore, comparative phylogenetic analysis of the aligned DNA sequences revealed divergence among the different viruses that can be consistently correlated to the host...
  85. doi The quest for orthologs: finding the corresponding gene across genomes
    Arnold Kuzniar
    Laboratory of Bioinformatics, Wageningen University, Dreijenlaan 3, 6703 HA Wageningen, The Netherlands
    Trends Genet 24:539-51. 2008
    ..Here, we evaluate the available bioinformatics tools and provide a set of guidelines to aid researchers in choosing the most appropriate tool for any situation...
  86. ncbi Complete genome sequence and biological characterizations of a novel goose paramyxovirus-SF02 isolated in China
    Jian Zou
    Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Virus Genes 30:13-21. 2005
    ..The SF02 genome shared 83% identity and its 6 ORFs 81.9-86.1% identities with the reference APMV-1 strains. The possible mechanism determining different host range and pathogenicity is discussed based on genetic analyses...
  87. pmc On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN)
    Naoki Numajiri
    Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Proc Natl Acad Sci U S A 108:10349-54. 2011
    ..Using this combination of techniques, we found that phosphatase with sequence homology to tensin (PTEN) is selectively S-nitrosylated by low concentrations of NO at a specific cysteine residue (..
  88. pmc Database resources of the National Center for Biotechnology
    David L Wheeler
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA
    Nucleic Acids Res 31:28-33. 2003
    ..Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. All of the resources can be accessed through the NCBI home page at: http://www.ncbi.nlm.nih.gov...
  89. pmc Full-length genome characterization of a novel simian immunodeficiency virus lineage (SIVolc) from olive Colobus (Procolobus verus) and new SIVwrcPbb strains from Western Red Colobus (Piliocolobus badius badius) from the Tai Forest in Ivory Coast
    Florian Liegeois
    UMR 145, Institut de Recherche pour le Developpement, 911, Avenue Agropolis, 34394 Montpellier, France
    J Virol 83:428-39. 2009
    ..Overall, these results suggest an ancestral link between these different lentiviruses and highlight once more the complexity of the natural history and evolution of primate lentiviruses...
  90. ncbi Genetic characterization of influenza A viruses (H5N1) isolated from 3rd wave of Thailand AI outbreaks
    Alongkorn Amonsin
    Faculty of Veterinary Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand
    Virus Res 122:194-9. 2006
    ..In addition, the genetic changes of the AI isolates at the HA cleavage site have been observed...
  91. pmc The genome of Gryllus bimaculatus nudivirus indicates an ancient diversification of baculovirus-related nonoccluded nudiviruses of insects
    Yongjie Wang
    Laboratory for Biotechnological Crop Protection, Department of Phytopathology, Agricultural Service Center Palatinate DLR Rheinpfalz, Breitenweg 71, 67435 Neustadt an der Weinstrasse, Germany
    J Virol 81:5395-406. 2007
    ..The accumulated information on the GbNV genome suggests that nudiviruses form a highly diverse and phylogenetically ancient sister group of the baculoviruses, which have evolved in a variety of highly divergent host orders...
  92. pmc New natural intergenotypic (2/5) recombinant of hepatitis C virus
    Florence Legrand-Abravanel
    Laboratoire de Virologie, Institut Fédératif de Biologie, INSERM U563, IFR30, 330 Ave de Grande Bretagne, TSA 40031, 31059 Toulouse Cedex 9, France
    J Virol 81:4357-62. 2007
    ..Knowing the location of the recombination point may also be useful for constructing infectious chimeric viruses...
  93. ncbi PartiGene--constructing partial genomes
    John Parkinson
    School of Biological Sciences, Ashworth Laboratories, King s Buildings, West Mains Rd, University of Edinburgh, Edinburgh EH9 3JT, UK
    Bioinformatics 20:1398-404. 2004
    ..nematodes.org) and LumbriBase (http://www.earthworms.org/). The packages are readily portable, freely available and can be run on simple Linux-based workstations...
  94. pmc Genetic diversity of the E protein of dengue type 3 virus
    Alberto A Amarilla
    Virology Research Center, School of Medicine of Ribeirão Preto USP, Ribeirao Preto SP, Brazil
    Virol J 6:113. 2009
    ..E protein gene sequences of 20 new viruses isolated in Ribeirao Preto, Brazil, and 427 sequences retrieved from GenBank were aligned for diversity and phylogenetic analysis...
  95. pmc Molecular characterization of human immunodeficiency virus type 1 (HIV-1) and HIV-2 in Yaounde, Cameroon: evidence of major drug resistance mutations in newly diagnosed patients infected with subtypes other than subtype B
    Nicaise Ndembi
    Laboratory of Hematology and Virology, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
    J Clin Microbiol 46:177-84. 2008
    ..3%) group M samples. None of the patients had any history of ART exposure. Population surveillance of transmitted HIV drug resistance is required and should be included to aid in the development of appropriate guidelines...
  96. doi Sequence identity between the genomes of humans and viruses
    Gui Gao Lin
    Graduate School, Peking Union Medical College, Beijing, PR China
    Intervirology 52:196-200. 2009
    ..It is possible that sequence identity may exist between viruses and humans and may be biologically relevant to the infection of virus. The aim of this study was to find out whether sequence identity exists between viruses and humans...
  97. ncbi Bayesian phylogenetic analysis reveals two-domain topology of S-adenosylhomocysteine hydrolase protein sequences
    Tomasz Stepkowski
    Plant Molecular Biology Laboratory, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61 704 Poznan, Noskowskiego 12 14, Poland
    Mol Phylogenet Evol 34:15-28. 2005
    ..The majority of cyanobacteria acquired this gene from Archaea, however, in some species the sahH gene was replaced by a copy from the beta- or gamma-Proteobacteria...
  98. pmc Increasing protein stability using a rational approach combining sequence homology and structural alignment: Stabilizing the WW domain
    X Jiang
    Department of Chemistry and The Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 Torrey Pines Road, La Jolla, CA 92037, USA
    Protein Sci 10:1454-65. 2001
    This study shows that a combination of sequence homology and structural information can be used to increase the stability of the WW domain by 2.5 kcal mol(-1) and increase the T(m) by 28 degrees C...
  99. doi Identification of two distinct bovine parainfluenza virus type 3 genotypes
    Paul Francis Horwood
    Department of Primary Industries and Fisheries, Ritchie Building 64A, Level 3, C Wing, Research Road, St Lucia, QLD 4072, Australia
    J Gen Virol 89:1643-8. 2008
    ..These newly identified genotypes have implications for the development of BPIV-3 molecular detection methods and may also impact on BPIV-3 vaccine formulations...
  100. ncbi The structure of calpain
    H Sorimachi
    Laboratory of Biological Function, Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    J Biochem 129:653-64. 2001
    ..This review will attempt to clarify all calpain homologues, to describe the common and differing features of calpain homologues in terms of structure-function relationship, and to discuss the evolutionary process of calpain...
  101. doi Identification of a new HIV Type 1 circulating recombinant form (CRF38_BF1) in Uruguay
    Dora Ruchansky
    Servicio de Virología Molecular, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
    AIDS Res Hum Retroviruses 25:351-6. 2009
    ..In addition we identified a new circulating recombinant form, designated CRF38_BF(1), which was dominant in the recombinant virus group...

Research Grants69

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Structure and function of urea transporters
    Ming Zhou; Fiscal Year: 2013
    ..We have recently crystallized a UT from the bacterium Desulfovibrio vulgaris (dvUT) that has significant sequence homology to mammalian UT, and have refined the crystals to diffract to a Bragg spacing of 2.3 [unreadable]...
  3. New therapeutics for the treatment of Acinetobactor baumannii infections.
    ALLEN BERNARD REITZ; Fiscal Year: 2013
    ..are marked differences between the components of the bacterial OxPhos with those of mitochondria and low sequence homology between the two, suggesting that pathogen-specific therapy by this approach is possible...
  4. Role of the insulin/IGF-axis in incident CIN-2+
    Howard D Strickler; Fiscal Year: 2010
    ..this relationship is due to the prevalence of hyperinsulinemia in obese women, since insulin has amino acid sequence homology, as well as mitogenic/anti-apoptotic activity, in common with IGF-I...
  5. Melanopsin Signal Transduction Studied by FTIR Spectroscopy
    Kenneth J Rothschild; Fiscal Year: 2012
    ..Similarities include a close primary sequence homology and signaling through the Gq-protein (phospholipaseC/inositol triphosphate) pathway instead of the Gt-..
  6. Novel Catalases and their Products
    Alan R Brash; Fiscal Year: 2013
    ..oxide synthase, an enzyme that catalyzes a cytochrome P450-type of reaction yet which exhibits distinct sequence homology to catalase...
  7. Developing a New Therapeutic for the Treatment of Invasive Aspergillosis
    Mitchell W Mutz; Fiscal Year: 2013
    ..The challenge of exploiting FC as an antifungal agent is due to structural and sequence homology with human calcineurin (HC)...
  8. Role of the Sex Hormones and Insulin/IGF-Axes in Endometrial Cancer Recurrence
    Howard D Strickler; Fiscal Year: 2012
    ..82), after controlling for estradiol. We also studied insulin-like growth factor-I (IGF-I). IGF-I shares sequence homology with insulin and is mitogenic...
  9. Molecular elucidation of the CBM complex in NF-kappaB activation by antigen recep
    Hao Wu; Fiscal Year: 2013
    ..despite having domains that belong to known protein families, CARMA1, Bcl10 and MALT1 exhibit very limited sequence homology to any of the known proteins...
  10. HTS assay development targeting Yersinia pestis topoisomerase I
    Yuk Ching Tse-Dinh; Fiscal Year: 2011
    ..Y. pestis topoisomerase I shares extensive sequence homology with topoisomerase I from E. coli and other gram negative bacteria...
  11. Regulation and Function of Adiponectin Oligomerization
    Feng Liu; Fiscal Year: 2012
    ..GST-kappa contains two thioredoxin domains and the C-terminal thioredoxin domain shares high structural and sequence homology to bacterial disulfide-bond-A (DsbA) oxidoreductase, an enzyme involved in disulfide bond formation in the ..
  12. Role of GLIS2 in the Development of Cystic Kidney Disease
    Massimo Attanasio; Fiscal Year: 2013
    ..GLIS2 is a transcription factor with high sequence homology to GLI1, GLI2 and GLI3, the vertebrate orthologs of Drosophila Ci (cubitus interruptus)...
  13. 3D Structure and Function of CRAC Channels
    STEPHEN BARSTOW LONG; Fiscal Year: 2013
    ..Aside from being an integral membrane protein, Orai has no significant amino acid sequence homology to other known ions channels...
  14. Role of Calcium-Activated Chloride Channels in Airway Disease Phenotypes
    ANAND CHAMPAK PATEL; Fiscal Year: 2011
    ..distinct genes in the mouse and 4 in the human, and each exhibits a high degree of intra- and inter-species sequence homology but a distinct pattern of expression in tissues...
  15. Modulation of Rab7-Dependent Degradative Pathways by Novel Adenovirus Protein
    Cathleen R Carlin; Fiscal Year: 2012
    ..In contrast RID[unreadable] is a non-enzymatic intrinsic membrane protein that lacks any sequence homology to Rab7, providing a remarkable example of convergent evolution...
  16. Mapping the functional major histocompatibility complex genes in zebrafish
    JILL L DE JONG; Fiscal Year: 2012
    ..each parent, there appear to be at least three chromosomal loci in the zebrafish with putative MHC genes by sequence homology. Despite substantial work mapping these MHC genes, there are almost no data characterizing their function...
  17. Monoallelic repair of expanded huntingtin by trans-splicing
    Hansjorg Rindt; Fiscal Year: 2011
    ..No effective therapy currently exists for HD. HTT is a soluble protein of ~3,144 amino acids that has no sequence homology with other proteins...
  18. Genetic Epidemiology of Osteosarcoma
    Logan G Spector; Fiscal Year: 2010
    ..SNP in public databases, 2) coding non-synonymous SNPs with deleterious function predicted by sequence homology algorithms, 3) effect of variant on protein function or expression reported in the literature...
  19. Development of Paratransgenic ticks for Disease Control
    ULRIKE GERTRUD MUNDERLOH; Fiscal Year: 2013
    ..routes of dispersal of SFG rickettsiae within ticks;identification of a plasmid in these rickettsiae having sequence homology with the R...
  20. Mechanisms of the M protein in group A Streptococcus virulence
    Victor Nizet; Fiscal Year: 2013
    ..recruit C4BP to the GAS surface for protection through a region that is non-conserved and lacks apparent sequence homology (Aim 3)...
  21. A Molecular Method to Selectively Record Activation of Dopamine Receptor Subtypes
    Gilad Barnea; Fiscal Year: 2012
    ..different receptors for dopamine that can be grouped into two classes based on their cellular signaling and sequence homology. The various types of receptors are thought to mediate different biological functions and are implicated in ..
  22. Iron acquisition mechanisms utilized by Neisseria gonorrhoeae
    Cynthia Nau Cornelissen; Fiscal Year: 2010
    ..Because the TonB-dependent transporters share sequence homology, genes that encode them can be identified within sequenced bacterial genomes. The presence of genes in the N...
  23. Fecal Phage: Exposing Unknown in the Dark Matter of the Human Gut
    Forest Rohwer; Fiscal Year: 2012
    ..and their 3D crystal structures will be determined in order to search for structural homology rather than sequence homology. The link between the presence of a predicted metabolic gene and human host health traits, such as obesity, ..
  24. Investigation of an unconventional co-repressor complex
    Yang Shi; Fiscal Year: 2012
    ..HDACs), methylases (G9a/EuHMT1), a demethylase (LSD1), and a nuclear protein (CDYL) that shares sequence homology with lipid metabolizing enzymes...
  25. Recruitment of Rad10 in Double-strand Break Repair
    PAULA LOUISE FISCHHABER; Fiscal Year: 2013
    ..of Rad10 recruitment to Double-Strand Breaks (DSBs) are altered depending on the extent and proximity of DNA sequence homology flanking the DSB site, 2) whether Rad10 recruitment in the "single-strand annealing" (SSA) mode of DSB ..
  26. SURFACE PROTEIN ANCHORING IN GRAM-POSITIVE BACTERIA
    Olaf Schneewind; Fiscal Year: 2013
    ..Four classes of sortases are distinguished on the basis of sequence homology and enzyme function...
  27. Novel Antimicrobials Targeting Cell Division
    Iwao Ojima; Fiscal Year: 2013
    ..The fact that the sequence homology between FtsZ and tubulin is low (<20% identity) strongly indicates an excellent possibility in ..
  28. FOXP3 Structure, Function and Regulatory Activity in T cells
    Troy Torgerson; Fiscal Year: 2009
    ..In each case, affected males develop fatal systemic autoimmune disease. The FOXP3 protein has significant sequence homology to the Forkhead/ Winged-helix family of transcription factors and also contains a C2H2 Zinc finger domain, a ..
  29. LYME ARTHRITIS: A NEW EPIDEMIC DISEASE
    Allen C Steere; Fiscal Year: 2010
    ..To broaden the search for candidate autoantigens beyond those identified by sequence homology with the OspA-,63-175 epitope, B cell epitopes of putative autoantigens will be sought using patient sera to ..
  30. Engineered Opioid Receptors as Therapeutic Agents for Pain Control
    Ping Yee Law; Fiscal Year: 2012
    ..approaches and others are viable ones, one of the reasons for their limited success is the high amino acid sequence homology among the cloned receptors...
  31. CELL CYCLE CHECKPOINT CONTROL IN RESPONSE TO DNA DAMAGE
    Nancy C Walworth; Fiscal Year: 2011
    ..are now known to function in the checkpoint pathway in mammalian cells were identified solely based on their sequence homology to proteins that were identified genetically and functionally in yeast...
  32. NUCKS, a novel double-strand break repair gene, implicated in cancer biology
    Claudia Wiese; Fiscal Year: 2013
    ..1, a region that is commonly gained in breast cancer. Based on sequence homology to RAD51 Associated Protein 1 (RAD51AP1), a critical factor in homologous recombination repair (HRR), we ..
  33. Unique Roles of p160 Coactivators during Human Adipogenesis
    Sean Hartig; Fiscal Year: 2010
    ..Additionally, SRC-1/SRC-3 double knockout mice exhibit a lean phenotype. Structurally, the pi 60s share sequence homology within the six domains responsible for NR and transcription factor interactions...
  34. Cardiolipin and the mitochondrial ADP/ATP carrier interactome
    STEVEN MICHAEL CLAYPOOL; Fiscal Year: 2013
    ..Ultimately, the high sequence homology between AAC isoforms will facilitate efforts to determine if Aac2p contains specific CL binding motifs and ..
  35. BETA LACTAMASE MUTATIONS IN ANTIBIOTIC RESISTANCE
    Timothy Palzkill; Fiscal Year: 2013
    ..lactamases have been grouped into four classes based on primary sequence homology. Classes A, C and D are active-site serine enzymes that catalyze the hydrolysis of ?-lactam antibiotics via ..
  36. Function of Longus Type IV pili in enterotoxigenic E coli
    OSCAR GOMEZ; Fiscal Year: 2010
    ..and one of the most prevalent pili described in human ETEC strains, has structural similarity and protein sequence homology to the well known virulence-associated T4Ps expressed by important human bacterial pathogens...
  37. Bacterial cation exporters: a new signaling paradigm for bacterial virulence
    Jason W Rosch; Fiscal Year: 2010
    ..including determining conserved domains via sequencing clinical strain and then generating mutants based on sequence homology to ascertain critical residues for metal specificity and protein function...
  38. Selective and dual-acting Hsp90 and TRAP1 inhibitors
    Duncan McRee; Fiscal Year: 2010
    ..Given the high degree of sequence homology (~70%) between the N-terminal domains of Hsp90 and TRAP1 (Fig...
  39. Cross-reactive HERV immunity to combat HIV-1 infection
    Donald E Mosier; Fiscal Year: 2010
    ..the expression of human endogenous retrovirus (HERV) elements that encode proteins that share sufficient sequence homology to engender cross-reactive immunity...
  40. An Investigation of the Chemical and Catalytic Mechanism of Pyruvate Carboxylase
    TONYA NICOLE ZECZYCKI; Fiscal Year: 2012
    ..etii PC holoenzyme and sequence homology, in the overall catalytic mechanism...
  41. Assessment of deubiquitinating and deISGylating activity;specificity motifs amon
    SCOTT DUSAN PEGAN; Fiscal Year: 2012
    ..Additionally, a low sequence homology homologue of vOTU has been suggested to perform a similar role in the economically devastating ssRNA (+) ..
  42. RNAi-based functional analysis of schistosome CD59-like as complement regulators
    Greice Krautz-Peterson; Fiscal Year: 2013
    ..Using genome and transcriptome analysis, seven putative schistosome CRPs with significant sequence homology to human CD59 were identified. These homologues are designated here as SmCD59-1, 2, 3, 4, 5, 6, 7...
  43. FAIM in Immunity and Autoimmunity
    THOMAS ROTHSTEIN; Fiscal Year: 2009
    ..FAIM is unique;it is highly evolutionarily conserved, yet does not contain sequence homology, or structural homology, with any other protein. In B cells FAIM acts as a force multiplier...
  44. DEVELOPING METHODS FOR CRYSTALLIZING FAMILY C GPCRS
    Dan Feng; Fiscal Year: 2013
    ..While they share the same 7 TM topology, there is no sequence homology with Family A receptors...
  45. FAIM in Immunity and Autoimmunity
    Thomas L Rothstein; Fiscal Year: 2013
    ..FAIM is unique;it is highly evolutionarily conserved, yet does not contain sequence homology, or structural homology, with any other protein. In B cells FAIM acts as a force multiplier...
  46. Structure and Function of Concentrative Nucleoside Transporters
    Seok Yong Lee; Fiscal Year: 2013
    ..vcCNT is an excellent model system to study hCNTs that shares significant sequence homology and functional properties with hCNTs. We solved the crystal structure of vcCNT in complex with uridine...
  47. Structural And Biochemical Characterization Of A Novel Mycobacterial Heme Uptake
    Celia Goulding; Fiscal Year: 2013
    ..With this in mind, the heme uptake pathway provides a number of good protein targets for the development of therapeutics against TB. ..
  48. LIPID METABOLISM IN THE RETINA
    Robert E Anderson; Fiscal Year: 2013
    ..macular dystrophy (STGD3, a juvenile form of macular degeneration) that encodes a protein with significant sequence homology to a family of proteins first identified in yeast that function in the elongation of fatty acids...
  49. Investigating the role of DISC1 using iPSCs from patients with mental disorders
    Ha Nam Nguyen; Fiscal Year: 2013
    ..gap in our knowledge because of the relatively low homology between mouse Disc1 and human DISC1 genes (~60% sequence homology)...
  50. BETA LACTAMASE MUTATIONS IN ANTIBIOTIC RESISTANCE
    Timothy Palzkill; Fiscal Year: 2010
    ..Based on primary sequence homology, p-lactamases have been grouped into four classes...
  51. Regulation of Mdmx stability and subcellular localization by ubiquitination
    Wei Gu; Fiscal Year: 2013
    ..Despite its high sequence homology with Mdm2 and the presence of a RING domain, Mdmx does not have intrinsic E3-ligase activity for p53 but was ..
  52. Mouse modeling of a human STING gene variant for infectious disease
    John C Cambier; Fiscal Year: 2013
    ..It is noteworthy that mouse and human STING proteins share 83% amino acid sequence homology. Thus in the first model (mHAQ mouse), we will make a STING knock-in in which the mouse equivalent amino ..
  53. Roles of protein structure and diiron cluster chemistry in oxygen activation
    John D Lipscomb; Fiscal Year: 2013
    ..b>Sequence homology, spectroscopy, and product analysis show that CmlA is the first diiron monooxygenase recognized to: (i) bind ..
  54. Role of gammaHV68 M1 antigen in Vbeta4+ T cell expansion and fibrosis
    Samuel H Speck; Fiscal Year: 2012
    ..The M1 antigen, which bears sequence homology to some pox virus serpins (although it lacks critical catalytic residues) and to the ?HV68 secreted high ..
  55. Temperature-Dependent Lethality of APL-1, a C. elegans Protein Related to Human A
    Christine Li; Fiscal Year: 2010
    ..We have identified a C. elegans gene, apl-1, that encodes an APP- related protein. APL-1 has strong sequence homology with the APP family proteins...
  56. UDP-Glucuronosyltransferases in responses to environmental and endogenous toxins
    Beverly H Koller; Fiscal Year: 2013
    ..Based on sequence homology it has not been possible to define the mouse ortholog of the seven human UGT2B genes...
  57. Role and mechanism of action of Gamma herpesvirus microRNAs
    Bryan R Cullen; Fiscal Year: 2011
    ..Our initial results indicate that the miRNAs expressed during latency by EBV and KHSV, despite their lack of sequence homology, nevertheless target a number of identical host mRNAs...
  58. Expression, Regulation, and Function of the Murine Voltage-Sensitive Phosphatase
    MARIO ROSASCO; Fiscal Year: 2013
    ..remarkable proteins contain a voltage sensor domain (VSD) comprised of 4 transmembrane segments, with high sequence homology to those VSDs found in voltage-sensitive ion channels [1]...
  59. Targeting the prostate-specific G-protein coupled receptors in prostate tumor
    Mingyao Liu; Fiscal Year: 2013
    ..Although these specific receptors shares sequence homology with olfactory GPCRs in their seven putative transmembrane domains, the expression of PSGRs is highly ..
  60. Structure/Function of AF9 and MLL-AF9
    Nancy J Zeleznik-Le; Fiscal Year: 2013
    ..At the time it was noted to share sequence homology to a component of the yeast SWI/SNF complex TFG3/ANC1, suggesting a role in transcription...
  61. Identification of human host factors involved in Chlamydia development
    Isabelle Derre; Fiscal Year: 2011
    ..RNAi treatment has been shown to be associated with the unintended silencing of genes displaying limited sequence homology with the targeted gene, we will perform a systematic validation procedure of the candidates to unambiguously ..
  62. A novel vaccine against vaginal Chlamydia trachomatis
    MICHAEL SEJR VAJDY; Fiscal Year: 2013
    ..Furthermore, combinations of mucosal and systemic vaccination routes, lack of sequence homology to human antigens, and promising preliminary results from both EpitoGenesis and the Dean lab warrant a novel ..
  63. MOLECULAR ANALYSIS OF CHROMOSOME SEGREGATION IN YEAST
    Clarence Chan; Fiscal Year: 1999
    ..in ploidy, the PI previously isolated a conditional mutation in the IPL1 gene which has significant sequence homology with a number of kinases implicated in chromosome segregation in higher eucaryotes (e.g...
  64. NEW GENE THERAPY FOR CONNECTIVE TISSUE DISEASES
    Eric Kmiec; Fiscal Year: 1999
    ..targeting and interference from the illegitimate recombination pathway that takes place independent of DNA sequence homology. We developed an experimental strategy that centers around site-specific correction of mutations using a ..
  65. Mechanisms of chemoattractant receptor regulation
    HEINI MIETTINEN; Fiscal Year: 2005
    ..They bind receptors that share significant sequence homology and structural features, and together they constitute a subfamily of G protein-coupled receptors (GPCR)...
  66. IL15 AND NATURAL KILLER (NK) CELL FUNCTION
    William Carson; Fiscal Year: 1999
    ..Recently, Grabstein et al have cloned a novel cytokine, IL-15, which has no sequence homology to IL-2 yet binds to components of the IL-2 receptor...
  67. Electronic/Molecular Structure of Enzyme Heme Pockets
    GERD LA MAR; Fiscal Year: 2009
    ..diphtheriae (CofHO) and N. meningitidis (NmHO), which share a common fold, but exhibit variable sequence homology for the residues involved in the H-bonding network...
  68. Role of penicillin binding protein 1a in GBS virulence
    Amanda Jones; Fiscal Year: 2006
    ..Based on sequence homology, the disrupted GBS gene is predicted to code for a class A, high molecular weight penicillin-binding protein ..
  69. REGULATION OF PILIN EXPRESSION
    H Seifert; Fiscal Year: 1993
    ..Gonococcal pilin is a member of a family of pilins that share amino acid sequence homology. The pilin genes from N...