polyploidy

Summary

Summary: The chromosomal constitution of a cell containing multiples of the normal number of CHROMOSOMES; includes triploidy (symbol: 3N), tetraploidy (symbol: 4N), etc.

Top Publications

  1. ncbi The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla
    Olivier Jaillon
    Genoscope CEA and UMR 8030 CNRS Genoscope Université d Evry, 2 rue Gaston Cremieux, BP5706, 91057 Evry, France
    Nature 449:463-7. 2007
  2. pmc The frequency of polyploid speciation in vascular plants
    Troy E Wood
    Institute for Evolution and Biodiversity, University of Munster, 48149 Munster, Germany
    Proc Natl Acad Sci U S A 106:13875-9. 2009
  3. ncbi Ancestral polyploidy in seed plants and angiosperms
    Yuannian Jiao
    Intercollege Graduate Degree Program in Plant Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nature 473:97-100. 2011
  4. ncbi Single nucleotide polymorphism (SNP) discovery in the polyploid Brassica napus using Solexa transcriptome sequencing
    Martin Trick
    John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Plant Biotechnol J 7:334-46. 2009
  5. ncbi Hybrid speciation
    James Mallet
    Galton Laboratory, Department of Biology, University College London, 4 Stephenson Way, London NW1 2HE, UK
    Nature 446:279-83. 2007
  6. pmc Unraveling ancient hexaploidy through multiply-aligned angiosperm gene maps
    Haibao Tang
    Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA
    Genome Res 18:1944-54. 2008
  7. pmc Single nucleotide polymorphism genotyping in polyploid wheat with the Illumina GoldenGate assay
    Eduard Akhunov
    Department of Plant Sciences, University of California, Davis, CA 95616, USA
    Theor Appl Genet 119:507-17. 2009
  8. pmc Plant speciation
    Loren H Rieseberg
    Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Science 317:910-4. 2007
  9. ncbi The advantages and disadvantages of being polyploid
    Luca Comai
    Department of Biology, Box 355325, University of Washington, Seattle, Washington 98195, USA
    Nat Rev Genet 6:836-46. 2005
  10. ncbi A physical map of the 1-gigabase bread wheat chromosome 3B
    Etienne Paux
    Institut National de la Recherche Agronomique, Université Blaise Pascal INRA UBP, UMR 1095, Genetics Diversity and Ecophysiology of Cereals, Clermont Ferrand, France
    Science 322:101-4. 2008

Detail Information

Publications362 found, 100 shown here

  1. ncbi The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla
    Olivier Jaillon
    Genoscope CEA and UMR 8030 CNRS Genoscope Université d Evry, 2 rue Gaston Cremieux, BP5706, 91057 Evry, France
    Nature 449:463-7. 2007
    ..Furthermore, we explain the chronology of previously described whole-genome duplication events in the evolution of flowering plants...
  2. pmc The frequency of polyploid speciation in vascular plants
    Troy E Wood
    Institute for Evolution and Biodiversity, University of Munster, 48149 Munster, Germany
    Proc Natl Acad Sci U S A 106:13875-9. 2009
    Since its discovery in 1907, polyploidy has been recognized as an important phenomenon in vascular plants, and several lines of evidence indicate that most, if not all, plant species ultimately have a polyploid ancestry...
  3. ncbi Ancestral polyploidy in seed plants and angiosperms
    Yuannian Jiao
    Intercollege Graduate Degree Program in Plant Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nature 473:97-100. 2011
    Whole-genome duplication (WGD), or polyploidy, followed by gene loss and diploidization has long been recognized as an important evolutionary force in animals, fungi and other organisms, especially plants...
  4. ncbi Single nucleotide polymorphism (SNP) discovery in the polyploid Brassica napus using Solexa transcriptome sequencing
    Martin Trick
    John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Plant Biotechnol J 7:334-46. 2009
    ..For a specimen region of the genome analysed in detail, segregation of alleles largely, although not entirely, followed the pattern expected for genomic markers...
  5. ncbi Hybrid speciation
    James Mallet
    Galton Laboratory, Department of Biology, University College London, 4 Stephenson Way, London NW1 2HE, UK
    Nature 446:279-83. 2007
    ..Now, new genetic evidence suggests that hybrid speciation, even without polyploidy, is more common in plants and also animals than we thought.
  6. pmc Unraveling ancient hexaploidy through multiply-aligned angiosperm gene maps
    Haibao Tang
    Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA
    Genome Res 18:1944-54. 2008
    ..Comparative analysis of inferred homologous genes derived from this model shows patterns of preferential gene retention or loss after polyploidy and reveals large variability of nucleotide substitution rates among plant nuclear genomes.
  7. pmc Single nucleotide polymorphism genotyping in polyploid wheat with the Illumina GoldenGate assay
    Eduard Akhunov
    Department of Plant Sciences, University of California, Davis, CA 95616, USA
    Theor Appl Genet 119:507-17. 2009
    ....
  8. pmc Plant speciation
    Loren H Rieseberg
    Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Science 317:910-4. 2007
    ..Finally, species richness in plants is correlated with many biological and geohistorical factors, most of which increase ecological opportunities...
  9. ncbi The advantages and disadvantages of being polyploid
    Luca Comai
    Department of Biology, Box 355325, University of Washington, Seattle, Washington 98195, USA
    Nat Rev Genet 6:836-46. 2005
    ..polyploid ancestry, suggesting that both humans and most other eukaryotes have either benefited from or endured polyploidy. Studies of polyploids soon after their formation have revealed genetic and epigenetic interactions between ..
  10. ncbi A physical map of the 1-gigabase bread wheat chromosome 3B
    Etienne Paux
    Institut National de la Recherche Agronomique, Université Blaise Pascal INRA UBP, UMR 1095, Genetics Diversity and Ecophysiology of Cereals, Clermont Ferrand, France
    Science 322:101-4. 2008
    ..This physical map establishes a template for the remaining wheat chromosomes and demonstrates the feasibility of constructing physical maps in large, complex, polyploid genomes with a chromosome-based approach...
  11. pmc Endoreplication: polyploidy with purpose
    Hyun O Lee
    Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genes Dev 23:2461-77. 2009
    ..Finally, we describe the molecular mechanisms that support the onset and progression of endoreplication...
  12. ncbi The evolutionary consequences of polyploidy
    Sarah P Otto
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Cell 131:452-62. 2007
    ..Nevertheless, polyploidy is well tolerated in many groups of eukaryotes...
  13. ncbi The role of hybridization in plant speciation
    Pamela S Soltis
    The Genetics Institute, Florida Museum of Natural History, University of Florida, Gainesville, Florida 32611, USA
    Annu Rev Plant Biol 60:561-88. 2009
    ..The time is therefore right for a review of the role of hybridization in plant speciation...
  14. pmc Altered circadian rhythms regulate growth vigour in hybrids and allopolyploids
    Zhongfu Ni
    Section of Molecular Cell and Developmental Biology, The University of Texas at Austin, One University Station, A 4800, Austin, Texas 78712, USA
    Nature 457:327-31. 2009
    ..The causal effects of CCA1 on output traits suggest that hybrids and allopolyploids gain advantages from the control of circadian-mediated physiological and metabolic pathways, leading to growth vigour and increased biomass...
  15. pmc Use of mRNA-seq to discriminate contributions to the transcriptome from the constituent genomes of the polyploid crop species Brassica napus
    Janet Higgins
    John Innes Centre, Norwich Research Park, Norwich, UK
    BMC Genomics 13:247. 2012
    b>Polyploidy often results in considerable changes in gene expression, both immediately and over evolutionary time...
  16. ncbi Tetraploidy, aneuploidy and cancer
    Neil J Ganem
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Genet Dev 17:157-62. 2007
    ..Therefore, abnormal division of tetraploid cells might facilitate genetic changes that lead to aneuploid cancers...
  17. pmc Genes encoding plastid acetyl-CoA carboxylase and 3-phosphoglycerate kinase of the Triticum/Aegilops complex and the evolutionary history of polyploid wheat
    Shaoxing Huang
    Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 99:8133-8. 2002
    ..timophevii are closely related, suggesting the same origin of some parts of their genomes. None of the Aegilops genomes analyzed is a close relative of the B genome, so the diploid progenitor of the B genome remains unknown...
  18. ncbi Unravelling angiosperm genome evolution by phylogenetic analysis of chromosomal duplication events
    John E Bowers
    Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA
    Nature 422:433-8. 2003
    ..better relate the evolutionary history of completely sequenced genomes to the tree of life, we foster comparative approaches to the study of genome organization, consequences of polyploidy, and the molecular basis of quantitative traits.
  19. ncbi The causes and consequences of polyploidy in normal development and cancer
    Teresa Davoli
    Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY 10065, USA
    Annu Rev Cell Dev Biol 27:585-610. 2011
    ..The origins of these polyploidization events and their consequences for tumor progression are explored in this review...
  20. pmc Plants with double genomes might have had a better chance to survive the Cretaceous-Tertiary extinction event
    Jeffrey A Fawcett
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, 9052 Gent, Belgium
    Proc Natl Acad Sci U S A 106:5737-42. 2009
    ....
  21. pmc Widespread paleopolyploidy in model plant species inferred from age distributions of duplicate genes
    Guillaume Blanc
    Department of Genetics, Smurfit Institute, University of Dublin, Trinity College, 2, Ireland
    Plant Cell 16:1667-78. 2004
    ..Large-scale duplications (polyploidy or aneuploidy) are strongly suspected to be the cause of these temporal peaks of gene duplication...
  22. pmc Genetic and epigenetic mechanisms for gene expression and phenotypic variation in plant polyploids
    Z Jeffrey Chen
    Department of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712, USA
    Annu Rev Plant Biol 58:377-406. 2007
    b>Polyploidy, or whole-genome duplication (WGD), is an important genomic feature for all eukaryotes, especially many plants and some animals...
  23. pmc Reciprocal silencing, transcriptional bias and functional divergence of homeologs in polyploid cotton (gossypium)
    Bhupendra Chaudhary
    Department of Plant and Wildlife Sciences, Brigham Young University, Provo, UT 84602, USA
    Genetics 182:503-17. 2009
    b>Polyploidy is an important force in the evolution of flowering plants...
  24. ncbi Understanding mechanisms of novel gene expression in polyploids
    Thomas C Osborn
    Dept of Agronomy, University of Wisconsin, Madison, WI 53706, USA
    Trends Genet 19:141-7. 2003
    b>Polyploidy has long been recognized as a prominent force shaping the evolution of eukaryotes, especially flowering plants...
  25. ncbi Polyploidy and genome restructuring: a variety of outcomes
    Andrew L Hufton
    Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
    Curr Opin Genet Dev 19:600-6. 2009
    ..In fact, striking differences in genome change after WGD can be observed within single plant genera, indicating that there are no simple rules that can predict a genome's reaction to WGD...
  26. ncbi The flowering world: a tale of duplications
    Yves Van de Peer
    Department of Plant Systems Biology, Flanders Institute for Biotechnology VIB, 9052 Gent, Belgium
    Trends Plant Sci 14:680-8. 2009
    ..Paleo-polyploidy events, in particular, have been the subject of much recent research...
  27. pmc Angiosperm genome comparisons reveal early polyploidy in the monocot lineage
    Haibao Tang
    Plant Genome Mapping Laboratory, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 107:472-7. 2010
    ..Although the exact timing of the sigma-duplication(s) is unclear because of uncertainties of the molecular clock assumption, our data suggest that it occurred early in the monocot lineage after its divergence from the eudicot clade...
  28. pmc Genomic and expression plasticity of polyploidy
    Scott Jackson
    Molecular and Evolutionary Genetics, Department of Agronomy, Purdue University, West Lafayette, IN 47907, USA
    Curr Opin Plant Biol 13:153-9. 2010
    b>Polyploidy or whole genome duplication (WGD) occurs throughout the evolutionary history of many plants and some animals, including crops such as wheat, cotton, and sugarcane...
  29. pmc Gene loss, silencing and activation in a newly synthesized wheat allotetraploid
    Khalil Kashkush
    Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel
    Genetics 160:1651-9. 2002
    ..These events contribute to the genetic diploidization of newly formed allopolyploids...
  30. pmc Genomewide nonadditive gene regulation in Arabidopsis allotetraploids
    Jianlin Wang
    Department of Agronomy, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 172:507-17. 2006
    b>Polyploidy has occurred throughout the evolutionary history of all eukaryotes and is extremely common in plants...
  31. pmc Changes in twelve homoeologous genomic regions in soybean following three rounds of polyploidy
    Andrew J Severin
    Department of Agronomy, Iowa State University, Ames, Iowa 50011, USA
    Plant Cell 23:3129-36. 2011
    ..enable characterization of patterns of the retention and evolution of genes within gene families due to multiple polyploidy events, gene loss and fractionation, and differential evolutionary pressures over time and across different gene ..
  32. ncbi Yesterday's polyploids and the mystery of diploidization
    K H Wolfe
    Department of Genetics, Smurfit Institute, Trinity College, University of Dublin, Dublin 2, Republic of Ireland
    Nat Rev Genet 2:333-41. 2001
    ..Sequence-level studies on model organisms whose genomes show clearer evidence of ancient polyploidy are invaluable because they indicate what the evolutionary products of genome duplication can look like...
  33. pmc Functional divergence of duplicated genes formed by polyploidy during Arabidopsis evolution
    Guillaume Blanc
    Department of Genetics, Smurfit Institute, University of Dublin, Trinity College, 2, Ireland
    Plant Cell 16:1679-91. 2004
    To study the evolutionary effects of polyploidy on plant gene functions, we analyzed functional genomics data for a large number of duplicated gene pairs formed by ancient polyploidy events in Arabidopsis thaliana...
  34. pmc Genomic changes in resynthesized Brassica napus and their effect on gene expression and phenotype
    Robert T Gaeta
    Department of Agronomy, University of Wisconsin, Madison, Wisconsin, USA
    Plant Cell 19:3403-17. 2007
    ..Our data indicate that exchanges among homoeologous chromosomes are a major mechanism creating novel allele combinations and phenotypic variation in newly formed B. napus polyploids...
  35. pmc PolyCat: a resource for genome categorization of sequencing reads from allopolyploid organisms
    Justin T Page
    Plant and Wildlife Science Department, Brigham Young University, Provo, Utah 84062, USA
    G3 (Bethesda) 3:517-25. 2013
    ....
  36. ncbi Nonadditive changes to cytosine methylation as a consequence of hybridization and genome duplication in Senecio (Asteraceae)
    Matthew J Hegarty
    Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Penglais Campus, Aberystwyth, Ceredigion SY23 3DA, UK
    Mol Ecol 20:105-13. 2011
    ..Widespread changes to gene expression have been shown to result from interspecific hybridisation and polyploidy in a number of plant species, and attention has now shifted to determining the epigenetic processes that drive ..
  37. pmc Molecular characterization of Rht-1 dwarfing genes in hexaploid wheat
    Stephen Pearce
    Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK
    Plant Physiol 157:1820-31. 2011
    ....
  38. pmc Genetic mapping of wild introgressions into cultivated peanut: a way toward enlarging the genetic basis of a recent allotetraploid
    Daniel Foncéka
    Centre de Cooperation Internationale en Recherche Agronomique pour le Developpement CIRAD, UMR Développement et Amélioration des Plantes, TA A96 3 Avenue Agropolis, Montpellier, France
    BMC Plant Biol 9:103. 2009
    ..duranensis and A. ipaënsis...
  39. ncbi Genome evolution in allopolyploid wheat--a revolutionary reprogramming followed by gradual changes
    Moshe Feldman
    Plant Sciences, The Weizmann Institute of Science, Rehovot, Israel
    J Genet Genomics 36:511-8. 2009
    ..These phenomena, emphasizing the dynamic plasticity of the allopolyploid wheat genome with regards to both structure and function, are described and discussed in this review...
  40. ncbi Tetraploidy and tumor development
    Robert L Margolis
    Institut de Biologie Structurale J P Ebel CEA CNRS UJF, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    Cancer Cell 8:353-4. 2005
    ..This p53-dependent elimination may represent a checkpoint control...
  41. ncbi Polyploidization of liver cells
    Séverine Celton-Morizur
    Institut Cochin, Universite Paris Descartes, CNRS, UMR 8104, INSERM U567, Paris, France
    Adv Exp Med Biol 676:123-35. 2010
    ..than two sets of chromosomes were first observed in plants about a century ago and it is now recognized that polyploidy cells form in many eukaryotes under a wide variety of circumstance...
  42. pmc Duplicate gene expression in allopolyploid Gossypium reveals two temporally distinct phases of expression evolution
    Lex Flagel
    Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA 50011, USA
    BMC Biol 6:16. 2008
    b>Polyploidy has played a prominent role in shaping the genomic architecture of the angiosperms. Through allopolyploidization, several modern Gossypium (cotton) species contain two divergent, although largely redundant genomes...
  43. ncbi Genome-wide genetic analysis of polyploidy in yeast
    Zuzana Storchova
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 443:541-7. 2006
    b>Polyploidy, increased sets of chromosomes, occurs during development, cellular stress, disease and evolution. Despite its prevalence, little is known about the physiological alterations that accompany polyploidy...
  44. pmc A linkage map for the B-genome of Arachis (Fabaceae) and its synteny to the A-genome
    Marcio C Moretzsohn
    EMBRAPA Recursos Geneticos e Biotecnologia, Brasilia, DF, Brazil
    BMC Plant Biol 9:40. 2009
    ..This can be overcome by the utilization of wild species of Arachis, which present the A- and B-genomes in the diploid state, and show high levels of genetic variability...
  45. pmc Complete switchgrass genetic maps reveal subgenome collinearity, preferential pairing and multilocus interactions
    Miki Okada
    US Department of Agriculture Agricultural Research Service, Genomics and Gene Discovery Research Unit, Western Regional Research Center, Albany, California 94710, USA
    Genetics 185:745-60. 2010
    b>Polyploidy is an important aspect of the evolution of flowering plants...
  46. ncbi Recombination: an underappreciated factor in the evolution of plant genomes
    Brandon S Gaut
    Department of Ecology and Evolutionary Biology, University of California Irvine, Irvine, California, USA
    Nat Rev Genet 8:77-84. 2007
    ..Much additional study of recombination in plants is needed to investigate these ideas further...
  47. pmc The more the better? The role of polyploidy in facilitating plant invasions
    Mariska Te Beest
    Centre for Invasion Biology, Department of Conservation Ecology and Entomology, Stellenbosch University, Private Bag X1, Matieland 7602, South Africa
    Ann Bot 109:19-45. 2012
    ..Recently, polyploidy (whole genome duplication) has been proposed as an important determinant of invasiveness in plants...
  48. pmc Genome-wide comparative analysis of the Brassica rapa gene space reveals genome shrinkage and differential loss of duplicated genes after whole genome triplication
    Jeong Hwan Mun
    Department of Agricultural Biotechnology, National Academy of Agricultural Science, Rural Development Administration, 150 Suin ro, Gwonseon gu, Suwon 441 707, Korea
    Genome Biol 10:R111. 2009
    ..Owing to its agronomic importance and phylogenetic position, B. rapa provides a crucial reference to understand polyploidy-related crop genome evolution...
  49. ncbi Evolutionary consequences of autopolyploidy
    Christian Parisod
    National Centre for Biosystematics, University of Oslo, 0318 Oslo, Norway
    New Phytol 186:5-17. 2010
    ..In addition, autopolyploids should possess increased genome flexibility, allowing them to adapt and persist across heterogeneous landscapes in the long run...
  50. ncbi From polyploidy to aneuploidy, genome instability and cancer
    Zuzana Storchova
    Department of Pediatric Oncology of The Dana Farber Cancer Institute, Children s Hospital and Harvard Medical School, Room M621A, 44 Binney Street Boston, Massachusetts 02115, USA
    Nat Rev Mol Cell Biol 5:45-54. 2004
    b>Polyploidy is a frequent phenomenon in the eukaryotic world, but the biological properties of polyploid cells are not well understood. During evolution, polyploidy is thought to be an important mechanism that contributes to speciation...
  51. pmc Phenotypic and transcriptomic changes associated with potato autopolyploidization
    Robert M Stupar
    Department of Horticulture, University of Wisconsin, Madison, WI 53706, USA
    Genetics 176:2055-67. 2007
    b>Polyploidy is remarkably common in the plant kingdom and polyploidization is a major driving force for plant genome evolution...
  52. ncbi The consequences of tetraploidy and aneuploidy
    Zuzana Storchova
    Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Cell Sci 121:3859-66. 2008
    b>Polyploidy, an increased number of chromosome sets, is a surprisingly common phenomenon in nature, particularly in plants and fungi. In humans, polyploidy often occurs in specific tissues as part of terminal differentiation...
  53. pmc Following tetraploidy in maize, a short deletion mechanism removed genes preferentially from one of the two homologs
    Margaret R Woodhouse
    Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Biol 8:e1000409. 2010
    ..Among the evolutionary benefits of this deletion/fractionation mechanism is bulk DNA removal and the generation of novel combinations of regulatory sequences and coding regions...
  54. pmc Endoreplication and polyploidy: insights into development and disease
    Donald T Fox
    Department of Pharmacology and Cancer Biology, and Department of Cell Biology, Duke University, Durham, NC 27710, USA
    Development 140:3-12. 2013
    ..and plant developmental systems have revealed evolutionarily conserved mechanisms that control the generation of polyploidy and have recently begun to provide clues to its physiological function...
  55. ncbi Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes
    Benjamin Leader
    Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, 200 Longwood Avenue, Boston, MA 02115, USA
    Nat Cell Biol 4:921-8. 2002
    ....
  56. pmc Repeated polyploidy drove different levels of crossover suppression between homoeologous chromosomes in Brassica napus allohaploids
    Marta Cifuentes
    Institut Jean Pierre Bourgin, Unité Mixte de Recherche 1318, INRA AgroParisTech Bâtiment 7, Institut National de Recherche Agronomique Centre de Versailles Grignon, 78026 Versailles Cedex, France
    Plant Cell 22:2265-76. 2010
    ..napus allohaploids. Overall, our results suggest that repeated polyploidy resulted in different levels of crossover suppression between homoeologs in B. napus allohaploids.
  57. ncbi Evolution of duplicate gene expression in polyploid and hybrid plants
    Keith L Adams
    UBC Botanical Garden and Centre for Plant Research and Department of Botany, University of British Columbia, Vancouver, BC, Canada
    J Hered 98:136-41. 2007
    ..Demonstrated mechanisms of gene expression changes include DNA methylation, histone modifications, and antisense RNA. Several hypotheses have been proposed for why gene expression is altered in allopolyploids and hybrids...
  58. ncbi Genomic plasticity and the diversity of polyploid plants
    A R Leitch
    School of Biological and Chemical Sciences, Queen Mary, University of London, London E1 4NS, UK
    Science 320:481-3. 2008
    b>Polyploidy, a change whereby the entire chromosome set is multiplied, arises through mitotic or meiotic misdivisions and frequently involves unreduced gametes and interspecific hybridization...
  59. ncbi Conservation of the microstructure of genome segments in Brassica napus and its diploid relatives
    Debashis Rana
    Department of Crop Genetics, John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, UK
    Plant J 40:725-33. 2004
    ..We aimed at overcoming the inherent complexity of Brassica genomes and clarify the effects of polyploidy on the evolution of genome microstructure in specific segments of the genome...
  60. pmc Small RNAs serve as a genetic buffer against genomic shock in Arabidopsis interspecific hybrids and allopolyploids
    Misook Ha
    Section of Molecular Cell and Developmental Biology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 106:17835-40. 2009
    ....
  61. pmc Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells
    Patrick Meraldi
    Department of Cell Biology, Max Planck Institute for Biochemistry, D 82152 Martinsried, Germany
    EMBO J 21:483-92. 2002
    ..We propose that errors during cell division, combined with the inability to detect the resulting hyperploidy, constitute a major cause for numerical centrosome aberrations in tumors...
  62. ncbi Evolution of polyploid triticum wheats under cultivation: the role of domestication, natural hybridization and allopolyploid speciation in their diversification
    Yoshihiro Matsuoka
    Fukui Prefectural University, Matsuoka, Eiheiji, Yoshida, Fukui 910 1195, Japan
    Plant Cell Physiol 52:750-64. 2011
    ....
  63. ncbi Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
    Takeshi Fujiwara
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 437:1043-7. 2005
    ..MMP overexpression is linked to mammary tumours in humans and animal models. Thus, tetraploidy enhances the frequency of chromosomal alterations and promotes tumour development in p53-/- MMECs...
  64. pmc Homoeologous shuffling and chromosome compensation maintain genome balance in resynthesized allopolyploid Brassica napus
    Zhiyong Xiong
    Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
    Proc Natl Acad Sci U S A 108:7908-13. 2011
    b>Polyploidy has contributed to the evolution of eukaryotes, particularly flowering plants...
  65. ncbi Recently formed polyploid plants diversify at lower rates
    Itay Mayrose
    Biodiversity Research Centre, University of British Columbia, Vancouver, BC V6T 1Z4, Canada
    Science 333:1257. 2011
    b>Polyploidy, the doubling of genomic content, is a widespread feature, especially among plants, yet its macroevolutionary impacts are contentious...
  66. ncbi Genomic changes in synthetic Arabidopsis polyploids
    Andreas Madlung
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    Plant J 41:221-30. 2005
    ..Activity of selected DNA transposons and the possibly related chromosomal breaks could cause changes by inducing translocations and rearrangements...
  67. pmc A preliminary analysis of genome structure and composition in Gossypium hirsutum
    Wangzhen Guo
    National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cotton Research Institute, Nanjing Agricultural University, Nanjing 210095, PR China
    BMC Genomics 9:314. 2008
    ..Here, we employed GeneTrek and BAC tagging information approaches to predict the general composition and structure of the allotetraploid cotton genome...
  68. ncbi Analysis of gene expression in resynthesized Brassica napus allotetraploids: transcriptional changes do not explain differential protein regulation
    Anne Marmagne
    CNRS, Ferme du Moulon, F 91190 Gif sur Yvette, France
    New Phytol 186:216-27. 2010
    b>Polyploidy, or whole genome duplication, is a major evolutionary process that has shaped eukaryotic genomes, notably those of flowering plants...
  69. ncbi Characterizing the composition and evolution of homoeologous genomes in hexaploid wheat through BAC-end sequencing on chromosome 3B
    Etienne Paux
    UMR ASP 1095, INRA, Universite Blaise Pascal, 63100 Clermont Ferrand, France
    Plant J 48:463-74. 2006
    ..Our data demonstrate that BAC-end sequencing from flow-sorted chromosomes is a powerful tool for analysing the structure and evolution of polyploid and highly repetitive genomes...
  70. pmc Stable epigenetic effects impact adaptation in allopolyploid orchids (Dactylorhiza: Orchidaceae)
    Ovidiu Paun
    Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey, United Kingdom
    Mol Biol Evol 27:2465-73. 2010
    ..Our results strongly suggest a need to expand our current evolutionary framework to encompass a complementary epigenetic dimension when seeking to understand population processes that drive phenotypic evolution and adaptation...
  71. ncbi Next generation sequencing reveals genome downsizing in allotetraploid Nicotiana tabacum, predominantly through the elimination of paternally derived repetitive DNAs
    Simon Renny-Byfield
    School of Biological and Chemical Sciences, Queen Mary University of London, London, United Kingdom
    Mol Biol Evol 28:2843-54. 2011
    ..Thus, the three genomes of N. sylvestris, N. tomentosiformis, and N. tabacum have experienced different evolutionary trajectories, with genomes that are dynamic, stable, and downsized, respectively...
  72. ncbi Allelic variation at the VRN-1 promoter region in polyploid wheat
    L Yan
    Department of Agronomy and Range Science, University of California, Davis, CA 95616, USA
    Theor Appl Genet 109:1677-86. 2004
    ..Based on these results, we concluded that the VRN-1 genes should have additional regulatory sites outside the promoter region studied here...
  73. ncbi Orthologous comparison in a gene-rich region among grasses reveals stability in the sugarcane polyploid genome
    Nazeema Jannoo
    Centro de Biologia Molecular e Engenharia Genetica, Universidade Estadual de Campinas, Campinas, SP, Brazil
    Plant J 50:574-85. 2007
    ..the high ploidy in sugarcane did not induce generalized reshaping of its genome, thus challenging the idea that polyploidy quickly induces generalized rearrangement of genomes...
  74. pmc Molecular mechanisms of polyploidy and hybrid vigor
    Z Jeffrey Chen
    Section of Molecular Cell and Developmental Biology, Center for Computational Biology and Bioinformatics, and Institute for Cellular and Molecular Biology, The University of Texas at Austin, One University Station A4800, Austin, TX 78712, USA
    Trends Plant Sci 15:57-71. 2010
    ....
  75. ncbi Allopolyploidy--a shaping force in the evolution of wheat genomes
    M Feldman
    Plant Sciences, The Weizmann Institute of Science, Rehovot, Israel
    Cytogenet Genome Res 109:250-8. 2005
    ..These phenomena, emphasizing the plasticity of the genome with regards to both structure and function, might improve the adaptability of the newly formed allopolyploids and facilitate their rapid and successful establishment in nature...
  76. ncbi Rate variation among nuclear genes and the age of polyploidy in Gossypium
    David S Senchina
    Department of Botany, Iowa State University, USA
    Mol Biol Evol 20:633-43. 2003
    ..Evidence from approximately 200,000 nucleotides (40,000 per genome) suggests that polyploidy in Gossypium led to a modest enhancement in rates of nucleotide substitution...
  77. ncbi Homoeologous nonreciprocal recombination in polyploid cotton
    Armel Salmon
    Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, IA 50011, USA
    New Phytol 186:123-34. 2010
    ..In addition, some genomic regions show multiple patterns of homoeologous recombination among species...
  78. pmc Meta-analysis of polyploid cotton QTL shows unequal contributions of subgenomes to a complex network of genes and gene clusters implicated in lint fiber development
    Junkang Rong
    Plant Genome Mapping Laboratory, University of Georgia, 111 Riverbend Road, Athens, GA 30602, USA
    Genetics 176:2577-88. 2007
    ..Meta-analysis linked to synteny-based and expression-based information provides clues about specific genes and families involved in QTL networks...
  79. ncbi Genomic clues to the evolutionary success of polyploid plants
    Matthew J Hegarty
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol, UK
    Curr Biol 18:R435-44. 2008
    b>Polyploidy, or the presence of two or more diploid parental genome sets within an organism, is found to an amazing degree in higher plants...
  80. ncbi Genome evolution in polyploids
    J F Wendel
    Department of Botany, Iowa State University, Ames 50011, USA
    Plant Mol Biol 42:225-49. 2000
    b>Polyploidy is a prominent process in plants and has been significant in the evolutionary history of vertebrates and other eukaryotes...
  81. pmc Numerous and rapid nonstochastic modifications of gene products in newly synthesized Brassica napus allotetraploids
    Warren Albertin
    UMR de Genetique Vegetale, INRA CNRS UPSud INA P G, La Ferme du Moulon, Gif sur Yvette, France
    Genetics 173:1101-13. 2006
    ..B. napus formation was therefore correlated with immediate and directed nonadditive changes in gene expression, suggesting that the early steps of allopolyploidization repatterning are controlled by nonstochastic mechanisms...
  82. ncbi JNK is constitutively active in mantle cell lymphoma: cell cycle deregulation and polyploidy by JNK inhibitor SP600125
    Miao Wang
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Pathol 218:95-103. 2009
    ..G2/M arrest was associated with down-regulation of EGR1 and p21 protein expression. SP600125-induced polyploidy could be blocked by the BCL-2 inhibitor YC137...
  83. ncbi Tissue-specific silencing of homoeologs in natural populations of the recent allopolyploid Tragopogon mirus
    Richard J A Buggs
    Department of Biology, University of Florida, Gainesville, FL 32611, USA
    New Phytol 186:175-83. 2010
    ..Our study shows that tissue-specific silencing, and even apparent subfunctionalization, can arise rapidly in the early generations of natural allopolyploidy...
  84. ncbi Characterization of duplicate gene evolution in the recent natural allopolyploid Tragopogon miscellus by next-generation sequencing and Sequenom iPLEX MassARRAY genotyping
    Richard J A Buggs
    Department of Biology, University of Florida, Gainesville, 32611, USA
    Mol Ecol 19:132-46. 2010
    ..These methods could be applied to any organism, allowing efficient and cost-effective generation of genetic markers...
  85. ncbi Unraveling the genome structure of polyploids using FISH and GISH; examples of sugarcane and banana
    A D'Hont
    CIRAD, UMR1096, Montpellier, France
    Cytogenet Genome Res 109:27-33. 2005
    ..FISH was used to analyze the distribution of repeated sequences along the genome...
  86. ncbi Identification and validation of a major QTL conferring crown rot resistance in hexaploid wheat
    J Ma
    CSIRO Plant Industry, 306 Carmody Road, St Lucia, QLD, 4067, Australia
    Theor Appl Genet 120:1119-28. 2010
    ....
  87. ncbi Evolutionary rate variation, genomic dominance and duplicate gene expression evolution during allotetraploid cotton speciation
    Lex E Flagel
    Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, IA 50011, USA
    New Phytol 186:184-93. 2010
    ..42 000 duplicated genes, and genome-specific expression for c. 1400 homoeologs (genes duplicated by polyploidy)...
  88. ncbi Genetic regulation of meiosis in polyploid species: new insights into an old question
    Marta Cifuentes
    Institut Jean Pierre Bourgin, Station de Génétique et Amélioration des Plantes, 78026 Versailles Cedex, France
    New Phytol 186:29-36. 2010
    ..Some of these advances are discussed, and it is suggested that research on polyploidy and on meiosis should no longer be unlinked.
  89. ncbi Phylogenetic relationships in Elymus (Poaceae: Triticeae) based on the nuclear ribosomal internal transcribed spacer and chloroplast trnL-F sequences
    Quanlan Liu
    The Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Institute of Biodiversity Science, Fudan University, Shanghai 200433, China
    New Phytol 170:411-20. 2006
    ....
  90. ncbi Dramatic change in function and expression pattern of a gene duplicated by polyploidy created a paternal effect gene in the Brassicaceae
    Shao Lun Liu
    UBC Botanical Garden and Centre for Plant Research, Vancouver, British Columbia, Canada
    Mol Biol Evol 27:2817-28. 2010
    New gene formation by polyploidy has been an ongoing process during the evolution of various eukaryotes that has contributed greatly to the large number of genes in their genomes...
  91. pmc Patterns of sequence loss and cytosine methylation within a population of newly resynthesized Brassica napus allopolyploids
    Lewis N Lukens
    Department of Plant Agriculture, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    Plant Physiol 140:336-48. 2006
    ..Our results suggest that there is little genetic change in the S(0) generation of resynthesized B. napus polyploids. In contrast, DNA methylation was altered extensively in a pattern that indicates tight regulation of epigenetic changes...
  92. pmc Roles of dynamic and reversible histone acetylation in plant development and polyploidy
    Z Jeffrey Chen
    Section of Molecular Cell and Developmental Biology, University of Texas at Austin, Austin, TX 78712, USA
    Biochim Biophys Acta 1769:295-307. 2007
    ..The reversible changes in histone acetylation also contribute to cell cycle regulation and epigenetic silencing of rDNA and redundant genes in response to interspecific hybridization and polyploidy.
  93. pmc Nonadditive expression of homoeologous genes is established upon polyploidization in hexaploid wheat
    Michael Pumphrey
    Department of Plant Pathology, Kansas State University, Manhattan, Kansas 66506, USA
    Genetics 181:1147-57. 2009
    Effects of polyploidy in allohexaploid wheat (Triticum aestivum L.) have primarily been ascribed to increases in coding sequence variation and potential to acquire new gene functions through mutation of redundant loci...
  94. ncbi Characteristics, development and mapping of Gossypium hirsutum derived EST-SSRs in allotetraploid cotton
    Zhiguo Han
    National Key Laboratory of Crop Genetics and Germplasm Enhancement, Cotton Research Institute, Nanjing Agricultural University, 210095 Nanjing, Jiangsu Province, P R China
    Theor Appl Genet 112:430-9. 2006
    ..EST-SSR markers were distributed over 20 chromosomes and 6 linkage groups in the map. These EST-SSR markers can be used in genetic mapping, identification of quantitative trait loci (QTLs), and comparative genomics studies of cotton...
  95. pmc Sequence elimination and cytosine methylation are rapid and reproducible responses of the genome to wide hybridization and allopolyploidy in wheat
    H Shaked
    Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel
    Plant Cell 13:1749-59. 2001
    ....
  96. ncbi A high-density genetic map of hexaploid wheat (Triticum aestivum L.) from the cross Chinese Spring x SQ1 and its use to compare QTLs for grain yield across a range of environments
    S A Quarrie
    John Innes Centre, Norwich Research Park, Colney Lane, Norwich, NR47UH, UK
    Theor Appl Genet 110:865-80. 2005
    ..Many of the yield QTL clusters corresponded with QTLs already reported in wheat and, on the basis of comparative genetics, also in rice. The implications of these results for improving wheat yield stability are discussed...
  97. ncbi The Ph1 locus is needed to ensure specific somatic and meiotic centromere association
    E Martinez-Perez
    John Innes Centre, Norwich Research Park, Colney, UK
    Nature 411:204-7. 2001
    ..This permits the correction of homologue association during the telomere-bouquet stage in meiosis. We conclude that the Ph1 locus is not responsible for the induction of centromere association, but rather for its specificity...
  98. pmc Ancient polyploidization predating divergence of the cereals, and its consequences for comparative genomics
    A H Paterson
    Plant Genome Mapping Laboratory, University of Georgia, Athens, GA 30602, USA
    Proc Natl Acad Sci U S A 101:9903-8. 2004
    ..Additional ancient duplication events probably remain to be discovered in other angiosperm lineages...
  99. pmc Altered gene expression and ecological divergence in sibling allopolyploids of Dactylorhiza (Orchidaceae)
    Ovidiu Paun
    Department of Systematic and Evolutionary Botany, University of Vienna, Rennweg, Austria
    BMC Evol Biol 11:113. 2011
    Hybridization and polyploidy are potent forces that have regularly stimulated plant evolution and adaptation. Dactylorhiza majalis s.s., D. traunsteineri s.l. and D...
  100. ncbi Newly synthesized wheat allohexaploids display progenitor-dependent meiotic stability and aneuploidy but structural genomic additivity
    Imen Mestiri
    Organization and evolution of Plant Genomes, Unite de Recherche en Genomique Vegetale, 91057 Evry Cedex, France
    New Phytol 186:86-101. 2010
    ....
  101. ncbi Cell death by mitotic catastrophe: a molecular definition
    Maria Castedo
    CNRS UMR 8125, Institut Gustave Roussy, Pavillon de Recherche 1, 39 rue Camille Desmoulins, Villejuif F 94805, France
    Oncogene 23:2825-37. 2004
    ....

Research Grants62

  1. Mechanism(s) of Hepatocyte Transformation by the Hepatitis B Virus X Protein
    Ourania M Andrisani; Fiscal Year: 2013
    ..In turn, Plk1 mediates checkpoint adaptation, generating partial polyploidy in non- transformed pX-expressing hepatocytes...
  2. Role of Polo-like kinase (Plk-1) in Hepatitis B Virus-mediated Hepatocellular Car
    Ourania M Andrisani; Fiscal Year: 2010
    ..have found that in non-transformed hepatocytes, pX induces DNA re-replication, resulting in DNA damage and polyploidy. As a result, the replication stress kinase ATR is activated which is known to activate p53...
  3. PKC/PKA Regulation in Prostate Cancer by SSeCKS/Gravin/AKAP12
    Irwin H Gelman; Fiscal Year: 2013
    ..of epithelial cell senescence, and KO mouse fibroblasts (MEF) display premature senescence correlating with polyploidy and binucleation...
  4. Angiotensin-induced Oxidants and Vascular Cell Phenotype
    Richard Cohen; Fiscal Year: 2009
    As the blood vessel ages, its cells are subject to pathological changes including hypertrophy, polyploidy, proliferation, apoptosis, and remodeling, and these processes are thought to be a result of complex interactions between ..
  5. High Throughput Transcriptome Sequencing for Systematic Detection of Recurrent Tr
    Chandan Kumar; Fiscal Year: 2012
    ..As a test case, we propose to analyze pancreatic cancer, which is the 4th most common cause of cancer related deaths in the US, with the worst prognosis of all major malignancies (5 year survival <3%). ..
  6. Impact of hepatocyte lineage life history dynamics on liver homeostasis in the ag
    Edward E Schmidt; Fiscal Year: 2013
    ..abstract_text> ..
  7. PROTEIN SEQUENCING BY TANDEM MASS SPECTROMETRY
    Donald F Hunt; Fiscal Year: 2013
    ..This modification is required for the prevention of genomic instability (polyploidy nuclei). Two other important proteins, retoblastoma B and CENP-A, are both trimethylated as well...
  8. Mechanisms of megakaryocyte maturation
    Diane S Krause; Fiscal Year: 2013
    ..In addition, the data obtained will reveal the molecular regulation and functions of MKL1, a transcriptional cofactor in the RhoA/SRF pathway, which is dysregulated in Myelodysplasia (MDS) especially that associated with 5q- syndrome. ..
  9. ONTOGENY AND PHYLOGENY OF THE MHC
    Martin Flajnik; Fiscal Year: 2009
    ..tropicalis), we will begin to analyze the modes of silencing in the tetraploids and eventually the higher order octo- and dodecaploid individuals. ..
  10. Polyploidy, aneuploidy and genome stability
    DAVID S PELLMAN; Fiscal Year: 2013
    ..Aneuploidy (abnormal chromosome number), including near polyploidy (increased genome sets), is a prominent feature of most cancers yet the consequences of this alteration of the ..
  11. Role of shear forces in proplatelet production from stem cells in bioreactors
    Eleftherios T Papoutsakis; Fiscal Year: 2012
    ..Breakup of polyploidy Mk cells takes place largely in the BM vasculature whereby Mk cells project cytoplasmic extensions through the ..
  12. Identifying Events and Genetic Regulators of Melanoma Progression
    CRAIG JOSEPH CEOL; Fiscal Year: 2012
    ..These studies may identify diagnostic and prognostic indicators of disease as well as therapeutic targets for cancer treatment. ..
  13. Control of Microtubule and Genome Integrity by the OBSL1-CUL7-CUL9-p53 Pathway
    Yue Xiong; Fiscal Year: 2013
    ..Deletion of Cul9 in mice resulted in wide spread polyploidy, spontaneous tumor development, and rendered mice susceptible to carcinogenesis indicating that Cul9 is a tumor ..
  14. Microenvironmental regulation of megakaryopoiesis and thrombopoiesis by SDF1
    LISA MADALEN NISWANDER; Fiscal Year: 2013
    ....
  15. Role of PTEN in Mitosis and Chromosome Stability
    Wen Hong Shen; Fiscal Year: 2013
    ..In our recent studies, we found that cells lacking PTEN exhibit chromosome missegregation and prominent polyploidy, suggesting that PTEN functions during mitosis to control genomic and karyotypic stability...
  16. Mechanisms of Cytokinesis in Yeast
    Erfei Bi; Fiscal Year: 2013
    ..Mechanistic study of mitosis has led to successful cancer therapies. Failure in cytokinesis leads to polyploidy and genetic instability that is often associated with tumors...
  17. Induction of genomic instability by HPV E6 and E7
    Jason J Chen; Fiscal Year: 2012
    ..Expression of the HPV E6 and E7 oncogenes in primary human keratinocytes (PHKs) leads to polyploidy, which is enhanced by spindle disruption and DNA damage...
  18. Abrogating a survival pathway in early colon cancer cells
    Nan Gao; Fiscal Year: 2013
    ..and apoptotic cell death, yet a great portion of mutant cells escape the checkpoint, becoming aneuploid and polyploidy-hallmarks of colon cancers...
  19. Regulation and function of the Clp 1p protein phosphatase
    Dannel McCollum; Fiscal Year: 2010
    ..Failure to do so can lead to polyploidy, genomic instability and cancer...
  20. GLYCOSYLATION AND CANCER
    Gerald Warren Hart; Fiscal Year: 2013
    ..Over-expression of OGT prevents cytokinesis causing polyploidy. We are elucidating the roles of the interplay of these enzymes and their substrates in regulating cytokinesis...
  21. Role of Cell Cycle Pathways in Traumatic Brain Injury (TBI)
    ALAN IRA FADEN; Fiscal Year: 2013
    ..mice (3) Cell cycle activation after TBI persists beyond the acute period and leads to progressively increased polyploidy of certain neurons in selectively vulnerable brain regions as demonstrated by slide-based cytometry and ..
  22. Evolution of Meiotic Mechanisms in Divergent Cytological Environments
    Kevin Wright; Fiscal Year: 2013
    ..b>Polyploidy is an ideal system to study this question, because there is strong selective pressure on the meiosis machinery ..
  23. The Role of p53 and 14-3-3 in Genomic Instability
    Jesse Martinez; Fiscal Year: 2009
    ..known to interact with the p53 tumor suppressor, can cause a form of chromosome instability that leads to polyploidy and replication of DNA in the absence of chromosome segregation suggesting that 14-3-3gamma can suppress the ..
  24. MKL in megakaryocytopoiesis
    Diane S Krause; Fiscal Year: 2013
    ..The results of these studies will provide new insights into the role of MKL1 in normal as well as malignant cells.) ..
  25. Pak1 Signaling and Targets in Breast Cancer Progression
    Rakesh Kumar; Fiscal Year: 2013
    ..which ensure S-phase progression and controlled mitosis and how it could significantly influence the status of polyploidy in breast cancer The purpose of this project is to clarify and define for the first time the significant role of ..
  26. Mechanisms Regulating Megakaryocyte Development
    Katya Ravid; Fiscal Year: 2013
    ..MK is unique among blood cells in attaining states of polyploidy, which precedes platelet biogenesis...
  27. Aberrant Megakaryopoiesis in the Myeloproliferative Neoplasms
    John D Crispino; Fiscal Year: 2013
    ....
  28. Assessment of Tumor Early Response to Treatment by Diffusion MRI
    Junzhong Xu; Fiscal Year: 2013
    ..before subsequent changes in cell density: 1) cells with multiple copies of DNA contents and organelles - polyploidy (>=8n);2) doubled copies of DNA contents and organelles in M phase (4n);and 3) cells arrested in pre-..
  29. Paradigms of Wound Healing and Fibrosis in the Eye
    Mary Ann Stepp; Fiscal Year: 2013
    ..size through a mechanism independent of DNA replication, but likely related to their unusual characteristic of polyploidy. The signals that mediate the expansion of the progenitor cells, their reprogramming to a repair phenotype and ..
  30. Aurora B-Induced Cytokinesis Defects in Malignant Cells
    William Saunders; Fiscal Year: 2013
    ..Within this broad category, the project will focus on the source of centrosome amplification and polyploidy. This is a newly emerging area of cancer biology and the mechanisms are poorly understood...
  31. Proteomic Study of Megakaryocyte Transcriptional Control
    Alan Cantor; Fiscal Year: 2007
    ..The results of this study should provide new insights into the transcriptional regulation of megakaryopoiesis, and possibly new therapeutic targets for disorders of megakaryocyte proliferation and development. ..
  32. Function of the Drosophila Myb Proto-Oncogene
    Joseph Lipsick; Fiscal Year: 2005
    ..show that loss of Dm-Myb function results in M phase arrest in mitotic tissues with increased aneuploidy and polyploidy, rather than G2 arrest as previously reported by others based on studies of ts-mutants...
  33. GLIOMA HETEROGENEITY AND CHEMOSENSITIVITY
    Adrienne Scheck; Fiscal Year: 2002
    ..FISH) and chromosome painting techniques demonstrated that many recurrent glioma cells that appear to lack 7/22 polyploidy by standard banding techniques contain additional fragments of these chromosomes in marker chromosomes...
  34. LUNG CANCER MODEL FOR SURGICAL RESEARCH
    JOHN BENFIELD; Fiscal Year: 1992
    ..Karyotyping tumors for humans and dogs will assess specific chromosomal abnormalities associated with the NSCLC polyploidy previously demonstrated in dogs and humans...
  35. NORMAL AND MUTANT CHORION GENES OF DROSOPHILA
    Allan Spradling; Fiscal Year: 2003
    ..Therefore, these studies will elucidate the structure and function of eukaryotic chromosomes, a subject of widespread importance to the genetics of all organisms, including humans. ..
  36. Abnormal Megakaryocyte Development
    DIANA GILLIGAN; Fiscal Year: 2006
    ..These cellular mechanisms will help explain the specialized processes that result in polyploidy and programmed cytoplasmic fragmentation (i.e. thrombopoiesis)...
  37. SIGNIFICANCE OF POLYPLOIDIZATION IN MEGAKARYOCYTOPOIESIS
    JOHN STRANEVA; Fiscal Year: 1991
    The objective of this research proposal is to determine the significance of polyploidy in megakaryocytopoiesis, because mature megakaryocytes (MK) are the immediate precursors of circulating platelets...
  38. Modulation of integrin function by cytoplasmic signals
    Ulhas Naik; Fiscal Year: 2007
    ..CIB overexpression in cells induces multinucleation (polyploidy)...
  39. SPINDLE POLES AND NUCLEAR PORES--YEAST NDC1 AND MPS2
    Mark Winey; Fiscal Year: 2003
    ..Failure in SPB duplication or in SPB function leads to anueploidy and polyploidy similar to that observed in many cancer cells...
  40. FoxM1B Protein in Stimulating Proliferation during Aging
    LESTER LAU; Fiscal Year: 2007
    ..abstract_text> ..
  41. HEPTOCYTE PROLIFERATION AND AFLATOXIN METABOLISM
    Stewart Sell; Fiscal Year: 2004
    ..the effect Of HBV associated injury and AFB I hepatocarcinogensis in these mice. In Specific Aim 3, the effect of HBV associated injury and AFB1 hepatocarcinogenesis in these mice will be examined. ..
  42. REGULATION OF POLYPLOIDY BY CYTIDYLYLTRANSFERASE (CT)
    Zheng Cui; Fiscal Year: 2002
    ..The proposed studies will provide insights into 1) the mechanism of polyploidy in cancer cells; 2) the coordination between ploidy control and PC synthesis; 3) a novel role of Bcl-2 in ..
  43. REPLICATION AND POLYTENIZATION IN DROSOPHILA DEVELOPMENT
    Terry Orr Weaver; Fiscal Year: 1992
    ....
  44. Mitotic Spindle Checkpoint Regulation by HPV E6 and E7
    Daksha Patel; Fiscal Year: 2004
    ..HPV 16 early proteins, E6 and E7, have been shown to be involved in chromosomal instability resulting in polyploidy and aneuploidy, although the mechanism is unclear...
  45. Identifying Events and Genetic Regulators of Melanoma Progression
    Craig Ceol; Fiscal Year: 2009
    ..These studies may identify diagnostic and prognostic indicators of disease as well as therapeutic targets for cancer treatment. ..
  46. GROWTH FACTORS IN NORMAL AND NEOPLASTIC HEMATOPOIESIS
    Kenneth Kaushansky; Fiscal Year: 2006
    ....
  47. RECEPTOR SIGNALING IN POLYPLOID VASCULAR SMOOTH MUSCLE
    Suzanne Oparil; Fiscal Year: 1992
    ..These studies should contribute to our basic understanding of the mechanisms of normal and altered VSMC responsiveness related to the pathogenesis of hypertension, atherosclerosis and arterial vasospasm...
  48. Modulation of a novel cell cycle checkpoint by the HPV oncogene E6
    Jason Chen; Fiscal Year: 2009
    ..Genomic instability in the form of polyploidy has been implicated in a causal role in carcinogenesis...
  49. NEW APPROACHES TO THE STUDY OF MEGAKARYOCYTOPOIESIS
    Carl Jackson; Fiscal Year: 1991
    ..These studies should yield basic insights into megakaryocyte differentiation and platelet formation as well as provide some understanding of megakaryocyte abnormalities in hereditary and acquired diseases...
  50. Gene expression effects of heterosis and ploidy level
    NICOLE RIDDLE; Fiscal Year: 2005
    ..Interactions between the effects of heterosis and polyploidy have been described and indicate that heterosis is stronger in polyploid individuals...
  51. PATHOLOGY OF MITOSIS IN VASCULAR SMOOTH MUSCLE
    Kenneth Walsh; Fiscal Year: 2005
    ..Aim 3: To determine the requirement of Cks1 function for Akt1-induced VSMC polyploidization. Aim 4: To generate transgenic animals that over express Cks1 or Akt1 in vascular smooth muscle. ..
  52. PRENATAL DIAGNOSIS USING FETAL CELLS FROM MATERNAL BLOOD
    Sherman Elias; Fiscal Year: 1991
    ..Methods will be developed for culturing fetal cells. Fetal aneuploidy and polyploidy will be detected by measuring fetal cellular DNA with flow cytometry (DNA indexing), a sensitive method ..
  53. MEGAKARYOCYTE PROLIFERATION AND ITS CONTROL
    Alexander Nakeff; Fiscal Year: 1980
    ..Since it is known that thrombopoietin production is shut off at this point, it serves as a reasonable time to examine the effect of decreased platelet production on CFU-M and their cycling state...
  54. DEVELOPMENTAL ANALYSIS OF RETINAL SYNAPTIC ORGANIZATION
    Leslie Fisher; Fiscal Year: 1980
    ..The retina of polyploid Xenopus larvae will also be analyzed quantitatively...
  55. GENETIC ANALYSIS OF AGING IN THE TRUE SLIME MOLDS
    Jimmy Clark; Fiscal Year: 1980
    ..Cytological investigations will also be made on the effects of polyploidy, both natural age related and constructed strains, on nuclear function and division cycle times...
  56. CHROMOSOME STRUCTURE DURING DROSOPHILA DEVELOPMENT
    Robert Glaser; Fiscal Year: 2000
    ..The novel nature of observations already made using this system suggest that continued analysis will reveal unanticipated aspects of DNA and chromosome structure of broad significance. ..
  57. Molecular Mechanisms of Genome Duplication
    ZENGJIAN CHEN; Fiscal Year: 2009
    ..abstract_text> ..
  58. THE ROLE OF PL3K IN THROMBOPOIETIN SIGNALING
    Amy Geddis; Fiscal Year: 2005
    ..A defined plan of training is presented in which the applicant will develop the experience and skills necessary for success as an independent investigator in Hematology. ..
  59. Mechanisms of In Vivo Cell Fusion
    Andrew Duncan; Fiscal Year: 2008
    ..Aim 2: To determine relevant properties of fusion-derived hepatocytes. Aim 3: To enhance in vivo cell fusion by expression of fusogenic viral envelope proteins. [unreadable] [unreadable] [unreadable]..
  60. BIOLOGY OF MONOCROTALINE INDUCED PULMONARY HYPERTENSION
    Dennis Wilson; Fiscal Year: 2005
    ..abstract_text> ..
  61. New Directions in Mutagenized ES Cell Libraries
    Andras Nagy; Fiscal Year: 2003
    ..Both strategies will be developed first in existing 129 ES cells, but will be transferred to newly derived C57BL/6 cell lines, as soon as they are validated, to provide mutations on the B6 'gold standard' background. ..