Genomes and Genes
Summary: The degree of replication of the chromosome set in the karyotype.
Publications253 found, 100 shown here
- Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signalingLarissa Lordier
INSERM, U790, Villejuif, France
Blood 112:3164-74. 2008..Our results suggest that the late failure of cytokinesis responsible for the endomitotic process is related to a partial defect in the Rho/Rock pathway activation...
- Ploidy regulation of gene expressionT Galitski
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Science 285:251-4. 1999..Ploidy-dependent repression of some G1 cyclins can explain the greater cell size associated with higher ploidies, and suggests ploidy-dependent modifications of cell cycle progression...
- Genome size variation and species relationships in Hieracium sub-genus Pilosella (Asteraceae) as inferred by flow cytometryJan Suda
Department of Botany, Faculty of Science, Charles University in Prague, Benatska 2, CZ 128 01 Prague, Czech Republic
Ann Bot 100:1323-35. 2007..In this study, genome size variation was investigated in a representative set of Central European hawkweeds in order to assess the value of such a data set for species delineation and inference of evolutionary relationships...
- Prognostic factors in surgical stage I endometrial carcinomaCaroline Lundgren
Department of Gynaecologic Oncology, Radiumhemmet Karolinska University Hospital, Stockholm, Sweden
Acta Oncol 43:49-56. 2004..001, p = 0.004), whereas only ploidy was significant in the endometrioid subgroup (p = 0.001). DNA ploidy was the strongest predictor of relapse-free survival and the only independent prognostic factor in the endometrioid subgroup...
- Transcriptome shock after interspecific hybridization in senecio is ameliorated by genome duplicationMatthew J Hegarty
School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, United Kingdom
Curr Biol 16:1652-9. 2006..cambrensis and this altered expression pattern is maintained in subsequent generations. These findings indicate that hybridization and polyploidization have immediate yet distinct effects on large-scale patterns of gene expression...
- Hierarchical classification of switchgrass genotypes using SSR and chloroplast sequences: ecotypes, ploidies, gene pools, and cultivarsJ E Zalapa
USDA ARS, Vegetable Crops Research Unit, Department of Horticulture, University of Wisconsin, Madison, WI, USA
Theor Appl Genet 122:805-17. 2011..This classification system is the first step toward developing switchgrass complementary gene pools that can be expected to provide a significant heterotic increase in biomass yield...
- Live birth after polar body array comparative genomic hybridization prediction of embryo ploidy-the future of IVF?Simon Fishel
CARE Fertility, John Webster House, 6 Lawrence Drive, Nottingham Business Park, Nottingham NG8 6PZ, United Kingdom
Fertil Steril 93:1006.e7-1006.e10. 2010....
- Gene expression analysis at the intersection of ploidy and hybridity in maizeNicole C Riddle
Division of Biological Sciences, University of Missouri, 117 Tucker Hall, Columbia, MO 65211, USA
Theor Appl Genet 120:341-53. 2010..Overall, we find that gene expression trends mirror observations from the phenotypic studies; however, obvious mechanistic connections remain unknown...
- Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic settingElisabeth Wik
Institute of Clinical Medicine, University of Bergen, and Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
Am J Obstet Gynecol 201:603.e1-7. 2009..The objective of the study was to investigate the prognostic impact of deoxyribonucleic acid (DNA) ploidy in endometrial carcinoma in a routine diagnostic series as compared with a research series...
- FZR2/CCS52A1 expression is a determinant of endoreduplication and cell expansion in ArabidopsisZachary Larson-Rabin
University of Wisconsin, Laboratory of Genetics, Department of Horticulture, Madison, Wisconsin 53706, USA
Plant Physiol 149:874-84. 2009..Our data, which suggest that reduced cell size can be compensated by increased cell proliferation to allow normal leaf morphology, are discussed with respect to the so-called compensation mechanism of plant development...
- BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in ArabidopsisChristian Breuer
Department of Cell and Developmental Biology, John Ines Centre, Norwich NR4 7UH, United Kingdom
Plant Cell 19:3655-68. 2007....
- Apomixis and reticulate evolution in the Asplenium monanthes fern complexRobert J Dyer
Department of Botany, Natural History Museum, London, UK
Ann Bot 110:1515-29. 2012..The purpose of this study was to elucidate the phylogenetic relationships in the A. monanthes complex and to investigate the occurrence and evolution of apomixis within this group...
- Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approachHana Raslova
INSERM Unité 790, Institut Gustave Roussy, 1 rue Camille Desmoulins, 94805 Villejuif, France
Blood 109:3225-34. 2007..Together, these results suggest that MK polyploidization per se does not regulate gene expression but is intrinsically included in the differentiation process...
- Intraspecific DNA content variability in Festuca pallens on different geographical scales and ploidy levelsPetr Smarda
Masaryk University, Faculty of Science, Institute of Botany and Zoology, Kotlarska 2, CZ 611 37 Brno, Czech Republic
Ann Bot 98:665-78. 2006....
- The gene balance hypothesis: from classical genetics to modern genomicsJames A Birchler
Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
Plant Cell 19:395-402. 2007
- The origin, evolution and proposed stabilization of the terms 'genome size' and 'C-value' to describe nuclear DNA contentsJohann Greilhuber
Institute of Botany and Botanical Garden of the University of Vienna, Austria
Ann Bot 95:255-60. 2005..Reconsideration of the terminology is required...
- Meiotic S-phase damage activates recombination without checkpoint arrestDaniel G Pankratz
Molecular and Cell Biology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
Mol Biol Cell 16:1651-60. 2005..Our results suggest that fission yeast meiosis is exceptionally tolerant of DNA damage, and that some forms of spontaneous S-phase damage can be repaired by recombination without activating checkpoint arrest...
- Vascular smooth muscle polyploidization as a biomarker for aging and its impact on differential gene expressionMatthew R Jones
Department of Biochemistry, Boston University, Boston, Massachusetts 02118, USA
J Biol Chem 279:5306-13. 2004..Our study is the first to describe aortic ploidy level as a biomarker for aging and to indicate that changes associated with increased DNA content per cell may selectively suppress the expression of specific genes...
- Production and characterization of amphiploids of Aegilops kotschyi and Ae. biuncialis with Secale cereale, and of backcross hybrids of Ae. biuncialis x S. cereale amphiploids with 2x and 4x S. cerealeBarbara Wojciechowska
Institute of Plant Genetics, Polish Academy of Sciences, Strzeszynska 34, 60 479 Poznan, Poland
J Appl Genet 46:157-61. 2005..The BC1 plants (2n = 4x = 28 and 2n = 5x = 35, respectively) were phenotypically intermediate between the parents and vigorous in vegetative growth. Some seeds were obtained only from the 35-chromosome BC1 hybrids...
- Large-scale genomic instability predicts long-term outcome for women with invasive stage I ovarian cancerG B Kristensen
Department of Gynecologic Oncology and Department of Pathology, The Norwegian Radium Hospital, Montebello, Oslo, Norway
Ann Oncol 14:1494-500. 2003..The objective was to evaluate the value of DNA ploidy using high-resolution image cytometry in predicting long-term survival of patients with early ovarian cancer...
- Six monophyletic lineages identified within Cryptococcus neoformans and Cryptococcus gattii by multi-locus sequence typingM Bovers
CBS Fungal Biodiversity Centre, Utrecht, The Netherlands
Fungal Genet Biol 45:400-21. 2008..In addition, four monophyletic lineages corresponding to the previously described genotypic groups were consistently found within C. gattii, indicating that these lineages should be considered different taxa as well...
- Aneuploidy and genetic variation in the Arabidopsis thaliana triploid responseIsabelle M Henry
Department of Biology, University of Washington, Seattle, Washington 98195 5325, USA
Genetics 170:1979-88. 2005..Thus, genetic variation was subject to selection contingent on the final ploidy and possibly acting during the protracted aneuploid phase...
- Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet releaseGianfranco Mattia
Department of Clinical Biochemistry, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
Blood 99:888-97. 2002..The data indicate the inability of the CB-MKs to progress in the endomitotic process and a direct correlation between DNA content and platelet production...
- Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factorSandra M Morillo
Department of Molecular, Cellular and Developmental Neurobiology, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Avenida Doctor Arce 37, E 28002 Madrid, Spain
Proc Natl Acad Sci U S A 107:109-14. 2010..Thus, a developmental program leading to somatic tetraploidy in specific retinal neurons exists in vertebrates. This program might occur in other vertebrate neurons during normal or pathological situations...
- A chromosome bin map of 16,000 expressed sequence tag loci and distribution of genes among the three genomes of polyploid wheatL L Qi
Department of Plant Pathology, Wheat Genetics Resource Center, Kansas State University, Manhattan, Kansas 66506 5502, USA
Genetics 168:701-12. 2004....
- Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeastC S Chan
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
Genetics 135:677-91. 1993..Molecular cloning and genetic mapping show that IPL1 is a newly identified gene, whereas IPL2 is allelic to BEM2, which is required for normal bud growth...
- Inhibition of the aurora kinases suppresses in vitro NT2-D1 cell growth and tumorigenicitySalvatore Ulisse
Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy
J Endocrinol 204:135-42. 2010..In conclusion, the above findings demonstrate that inhibition of aurora kinase activity is effective in reducing in vitro growth and tumorigenicity of NT2-D1 cells, and indicate its potential therapeutic value for TGCT treatment...
- Chromosome sorting in tetraploid wheat and its potential for genome analysisMarie Kubaláková
Laboratory of Molecular Cytogenetics and Cytometry, Institute of Experimental Botany, Olomouc, Czech Republic
Genetics 170:823-9. 2005..This study considerably expands the potential of flow cytogenetics for use in wheat genomics and opens the possibility of sequencing the genome of this important crop one chromosome arm at a time...
- Homozygosity at the MTL locus in clinical strains of Candida albicans: karyotypic rearrangements and tetraploid formationMelanie Legrand
Department of Genetics, Cell Biology, and Development, University of Minnesota, 321 Church St SE, Minneapolis, MN 55455, USA
Mol Microbiol 52:1451-62. 2004..Furthermore, as clinical strains can mate and form tetraploids, mating and marker exchange are likely to be a significant part of the life cycle of C. albicans in vivo...
- Genetic variation for the response to ploidy change in Zea mays LNicole C Riddle
Division of Biological Sciences, University of Missouri Columbia, 117 Tucker Hall, Columbia, MO 65211 7400, USA
Theor Appl Genet 114:101-11. 2006..The other source is genotype specific and results in a response to ploidy change that varies among inbred lines. This finding demonstrates the existence of genetic variation for the morphological response to ploidy change in Zea mays...
- Phenotypic consequences of genetic variation in a gynogenetic complex of Phoxinus eos-neogaeus clonal fish (Pisces: Cyprinidae) inhabiting a heterogeneous environmentMatthew R Doeringsfeld
Department of Biology, University of North Dakota, Grand Forks, North Dakota 58202 9019, USA
Evolution 58:1261-73. 2004....
- Prospective multicenter validation confirms the prognostic superiority of the endometrial carcinoma prognostic index in international Federation of gynecology and obstetrics stage 1 and 2 endometrial carcinomaJan P A Baak
Department of Pathology, Rogaland Central Hospital, Stavanger, Norway
J Clin Oncol 21:4214-21. 2003..To validate the prognostic value of the endometrial carcinoma prognostic index (ECPI; combined myometrium invasion, flow cytometric DNA ploidy, and morphometric mean shortest nuclear axis [MSNA]) versus classic prognosticators...
- Core classification of lung cancer: correlating nuclear size and mitoses with ploidy and clinicopathological parametersIver Petersen
Institute of Pathology, Universitatsklinikum Jena, Jena, Germany
Lung Cancer 65:312-8. 2009..e. 2c deviation index and 5c exceeding rate, were predictors of poor survival in NSCLC patients. As a complement to histologic tumour diagnosis the core classification should help to better stratify cancer subtypes...
- Developmental potential of mouse tetraploid cells in diploid <--> tetraploid chimeric embryosYuji Goto
Division of Bioscience, Graduate School of Environmental Earth Science and Research Center for Molecular Genetics, Hokkaido University, Japan
Int J Dev Biol 46:741-5. 2002..The complete lack of 4n cell contribution to chimeras produced by the standard procedure is therefore attributed to the initial low proportion of 4n cells allocated to epiblast and their severe elimination from embryonic tissues...
- Control of DNA replication and chromosome ploidy by geminin and cyclin AIvailo S Mihaylov
Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Mol Cell Biol 22:1868-80. 2002..Together, our studies indicate that both cyclin A and geminin are required for the suppression of overreplication and for genome stability in Drosophila cells...
- Chromosome numbers and genome size variation in Indian species of Curcuma (Zingiberaceae)Jana Leong-Skornicková
Department of Botany, Charles University in Prague, Benatska 2, Prague 2, CZ 12801, Czech Republic
Ann Bot 100:505-26. 2007..In the present study, an investigation was made of chromosomal and genome size variation in the majority of Curcuma species from the Indian subcontinent, and an assessment was made of the value of these data for taxonomic purposes...
- An allometric relationship between mitotic spindle width, spindle length, and ploidy in Caenorhabditis elegans embryosYuki Hara
Cell Architecture Laboratory, Structural Biology Center, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411 8540, Japan
Mol Biol Cell 24:1411-9. 2013..On the basis of this equation, we propose a force-balance model to determine the spindle width...
- Nuclear DNA C-values in 30 species double the familial representation in pteridophytesRenate Obermayer
Jodrell Laboratory, Royal Botanic Gardens, Richmond, Surrey, UK
Ann Bot 90:209-17. 2002..7 pg in Psilotum nudum var. gasa. Superimposing C-value data onto a robust phylogeny of pteridophytes suggests some possible trends in C-value evolution and highlights areas for future work...
- Scp160p, a new yeast protein associated with the nuclear membrane and the endoplasmic reticulum, is necessary for maintenance of exact ploidyU Wintersberger
Department of Molecular Genetics, University of Vienna, Austria
Yeast 11:929-44. 1995..Taken together the data suggest that the Scp160 protein is required during cell division for faithful partitioning of the ER-nuclear envelope membranes which in S. cerevisiae enclose the duplicated chromosomes...
- Cytoplasmic and genomic effects on meiotic pairing in Brassica hybrids and allotetraploids from pair crosses of three cultivated diploidsCheng Cui
National Key Laboratory of Crop Genetic Improvement, National Center of Crop Molecular Breeding Technology, National Center of Oil Crop Improvement Wuhan, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
Genetics 191:725-38. 2012..Our results highlight the specific roles of the cytoplasm and genome to the chromosomal behaviors of hybrids and allopolyploids...
- Prognostic importance of DNA ploidy and DNA index in stage I and II endometrioid adenocarcinoma of the endometriumM Pradhan
Institute for Medical Informatics, Department of Pathology, Oslo University Hospital, Oslo, Norway
Ann Oncol 23:1178-84. 2012..We evaluated the prognostic importance of DNA ploidy in stage I and II endometrioid adenocarcinoma (EAC) of the endometrium with a focus on DNA index...
- DNA ploidy analysis as an adjunct for the detection of relapse in B-lineage acute lymphoblastic leukemiaBarton Kenney
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
Leuk Lymphoma 49:42-8. 2008..These results suggest that it may be beneficial to perform ploidy analysis as an adjunct to flow immunophenotyping in following patients with B-lineage ALL who demonstrate aneuploidy at diagnosis...
- DNA ploidy heterogeneity in endometrial carcinoma: comparison between curettage and hysterectomy specimensManohar Pradhan
Department of Pathology, Oslo University Hospital, University of Oslo, Oslo, Norway
Int J Gynecol Pathol 29:572-8. 2010..The difference observed, which we believe reflects the intratumoral heterogeneity, should be taken into account when applying DNA ploidy to endometrial carcinoma specimens...
- Evaluation of DNA ploidy in relation with established prognostic factors in patients with locally advanced (unresectable) or metastatic pancreatic adenocarcinoma: a retrospective analysisNikolas Tsavaris
Oncology Unit, Department of Pathophysiology, Laikon General Hospital, Athens University School of Medicine, Athens, Greece
BMC Cancer 9:264. 2009..The aim of this study was to evaluate the prognostic significance of DNA ploidy in relation with established clinical and laboratory variables in such patients...
- Molecular and histopathologic predictors of distant failure in endometrial cancerAndrea Mariani
Department of Obstetrics and Gynecology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Cancer Detect Prev 27:434-41. 2003..01). Thus, locoregional therapy may be insufficient when at least one of these predictors is present...
- Flow cytometric analysis of DNA ploidy and S-phase fraction from prostatic carcinomas: implications for prognosis and response to endocrine therapyT Visakorpi
Department of Clinical Chemistry, Tampere University Hospital, Finland
Br J Cancer 64:578-82. 1991..SPF was also the best predictor of progression free survival in patients treated hormonally. In conclusion, detection of high SPF in prostate cancer may indicate lack of hormonal responsiveness and poor prognosis...
- Phenotypic and cytologic studies of lymphoid cells and monocytes in primary culture of porcine bone marrow during infection of African swine fever virusE M Karalova
Laboratory of Cell Biology, Institute of Molecular Biology NAS RA, PO Box 0014, Yerevan, Armenia
In Vitro Cell Dev Biol Anim 47:200-4. 2011..The cytophotometry of main and additional nuclei showed that DNA content didn't exceed diploid standard which indicates that the additional nuclei were consequence of fragmentation of nuclei in lymphocytes...
- DNA ploidy is an independent prognostic indicator of overall survival in stage I endometrial endometrioid carcinomaMarkku Santala
Department of Obstetrics and Gynecology, University of Oulu, Finland
Anticancer Res 23:5191-6. 2003..The current retrospective follow-up study aimed to evaluate DNA ploidy, S-phase fraction and preoperative serum CA 125 level as prognostic factors of endometrial endometrioid adenocarcinoma...
- Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cellsM Tatsuka
Department of Regulatory Radiobiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
Cancer Res 58:4811-6. 1998..Thus, defects of pathways essential for mitotic regulation are important during human cancer development...
- DNA ploidy, E-cadherin, beta-catenin expression and their clinicopathologic significance in imprints of non-small cell lung cancerGeorge Chelidonis
1st Pathology Department and Cytology Unit, Medical School, Athens University, Athens, Greece
Anal Quant Cytol Histol 31:332-9. 2009..To evaluate, in imprints of resected non-small cell lung cancers (NSCLCs), the relationship between DNA ploidy and E-cadherin/beta-catenin expression with classical prognostic factors...
- DNA-ploidy in advanced gastric carcinoma is less heterogeneous than in early gastric cancerMaria Chiara Osterheld
Institut Universitaire de Pathologie, Rue du Bugnon25, 1011 Lausanne, Switzerland
Cell Oncol 26:21-9. 2004....
- Long-term genome diploidization in allopolyploid Nicotiana section Repandae (Solanaceae)James J Clarkson
Jodrell Laboratory, Royal Botanic Gasrdens, Kew, Richmond, Surrey, TW9 3DS, UK
New Phytol 168:241-52. 2005..In Nicotiana, 4.5 Myr of allopolyploid evolution renders genomic in situ hybridization (GISH) unsuitable for the complete resolution of parental genomes...
- The role of DNA ploidy in postoperative management of stage I endometrial cancerG Mangili
Division of Gynecology and Obstetrics, IRCCS San Raffaele Hospital, University of Milan, Milan, Italy
Ann Oncol 19:1278-83. 2008..Decision is on the basis of traditional prognostic factors. We report our experience in which ploidy has found to play a role in clinical practice since 1999...
- Gross genomic damage measured by DNA image cytometry independently predicts gastric cancer patient survivalJ A M Belien
Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
Br J Cancer 101:1011-8. 2009..The aim of our study was to compare the DNA ploidy status measured using FCM-DNA and ICM-DNA in gastric cancer and to evaluate its association with clinicopathological variables...
- Euploidy in somatic cells from R6/2 transgenic Huntington's disease miceAsa Petersen
Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden
BMC Cell Biol 6:34. 2005..Aneuploidy is normally a feature closely connected to neoplastic disease. To further explore this unexpected aspect of HD, we studied cultures derived from 6- and 12-week-old R6/2 fibroblasts, skeletal muscle cells, and liver cells...
- Implications of hybridisation and cytotypic differentiation in speciation assessed by AFLP and plastid haplotypes--a case study of Potentilla alpicola La SoieJuraj Paule
Department of Biodiversity and Plant Systematics, Centre for Organismal Studies Heidelberg, Heidelberg University, Heidelberg, Germany
BMC Evol Biol 12:132. 2012..In the present study, the alpine taxon Potentilla alpicola has been chosen in order to study its presumed hybrid origin, identify underlying evolutionary processes and infer the discreteness or taxonomic value of hybrid forms...
- Prognostic impact of Deoxyribonucleic acid (DNA) image analysis cytometry and immunohistochemical expression of Ki67 in surgically resected non-small cell lung cancersNicoletta F Maounis
Department of Cytology, Sismanoglion General Hospital, 1 Sismanogliou Str, Athens 151 26, Greece
Cancer Detect Prev 30:507-14. 2006..The aim of the present study was to evaluate the prognostic significance of DNA ploidy and Ki67 expression in non-small cell lung carcinoma (NSCLC)...
- Significance of morphometric, DNA cytometric features, and other prognostic markers on survival of endometrial cancer patients in northern NorwayA Ørbo
Department of Pathology, Institute of Medical Biology, Faculty of Medicine, University Hospital of Tromsø, N 9037 Tromsø, Norway
Int J Gynecol Cancer 12:49-56. 2002....
- Identification of intergenomic translocations involving wheat, Hordeum vulgare and Hordeum chilense chromosomes by FISHP Prieto
Instituto de Agricultura Sostenible CSIC, Apdo 4084, 14080 Cordoba, Spain
Hereditas 135:171-4. 2001..Frequencies of plants containing different kinds of intergenomic translocations between chromosome arms are presented. These lines can be useful for introgressing into tritordeum characters of interest from H. vulgare...
- Adenocarcinoma corpus uteri stage I-II: results of a treatment programme based upon cytometryBengt Lindahl
Department of Obstetrics and Gynaecology University Hospital Lund, Sweden
Anticancer Res 29:4731-5. 2009..We therefore recommend future research to be directed toward cytostatics as an alternative adjuvant treatment...
- Direct visualization of the endomitotic cell cycle in living megakaryocytes: differential patterns in low and high ploidy cellsNicholas Papadantonakis
Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Cell Cycle 7:2352-6. 2008..This is the first study to document chromosomal segregation patterns during endomitosis ex vivo and to indicate their potential differential regulation in low and high ploidy cells...
- Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damageRobert J D Reid
Columbia University Medical Center, Department of Genetics and Development, New York, NY 10032, USA
Genome Res 21:477-86. 2011..These findings demonstrate the utility of the SPA technique to introduce plasmids into the haploid gene-disruption library to discover new interacting pathways...
- A simple method for the calculation of microsatellite genotype distances irrespective of ploidy levelRuzica Bruvo
Department of Evolutionary Biology, Institute for Animal Evolution and Ecology, Westphalian Wilhelms University, Hüfferstr 1, 48149 Munster, Germany
Mol Ecol 13:2101-6. 2004..An illustration is given using data from the planarian flatworm Schmidtea polychroa (Platyhelminthes)...
- Comparative sequence analysis of MONOCULM1-orthologous regions in 14 Oryza genomesFei Lu
State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
Proc Natl Acad Sci U S A 106:2071-6. 2009..6 and 0.4 Mya, respectively. In allotetraploids, pseudogenization of duplicated genes was common, caused by large deletions, small frame-shifting insertions/deletions, or nonsense mutations...
- Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arraysTatiana Popova
Centre de Recherche, Institut Curie, 26 Rue d Ulm, Paris, 75248, France
Genome Biol 10:R128. 2009..Assignments were verified by DNA indexes of primary tumors and karyotypes of cell lines. The method performs well even for poor-quality data, low tumor content, and highly rearranged tumor genomes...
- Entamoeba shows reversible variation in ploidy under different growth conditions and between life cycle phasesChandrama Mukherjee
Department of Biochemistry, Bose Institute, Kolkata, India
PLoS Negl Trop Dis 2:e281. 2008..Our studies demonstrate the inherent plasticity and dynamic nature of the Entamoeba genome in at least two species...
- Chromatin assembly factor CAF-1 is required for cellular differentiation during plant developmentVivien Exner
Institute of Plant Sciences and Basel Zurich Plant Science Center, ETH Zurich, 8092 Zurich, Switzerland
Development 133:4163-72. 2006..These results reveal that the functions of FAS1, FAS2 and MSI1 are not restricted to meristems, but are also needed to control genome replication at multiple steps of development...
- A prospective population-based management program including primary surgery and postoperative risk assessment by means of DNA ploidy and histopathology. Adjuvant radiotherapy is not necessary for the majority of patients with FIGO stage I-II endometrial cT Hogberg
Department of Gynecologic Oncology, University Hospital, Linkoping, Sweden
Int J Gynecol Cancer 14:437-50. 2004..Thus, effective systemic treatments need to be developed. Low-risk patients, constituting the majority (84%) of the patients, can be safely treated by surgery only...
- Spontaneous deletions and reciprocal translocations in Saccharomyces cerevisiae: influence of ploidyYves Tourrette
UMR 7156 Université Louis Pasteur CNRS, Genetique Moleculaire, Genomique, Microbiologie, Département Microorganismes, Génomes, Environnement, Strasbourg, France
Mol Microbiol 64:382-95. 2007..After discussing the differences between the haploid and diploid levels, some mechanisms possibly involved in chromosome shortening and arm exchange are suggested...
- DNA ploidy and S-phase fraction as prognostic factors in surgically resected gastric carcinoma: a 7-year prospective studyGabriella Nesi
Department of Human Pathology and Oncology, University of Florence, Florence, Italy
Anticancer Res 27:4435-41. 2007..DNA ploidy and S-phase fraction (SPF) measured by DNA flow cytometry (FC) have been previously shown to correlate with several clinicopathological variables in several types of tumours...
- p53 deficiency exacerbates pleiotropic mitotic defects, changes in nuclearity and polyploidy in transdifferentiating pancreatic acinar cellsNathalie Sphyris
Division of Pathology, School of Molecular and Clinical Medicine, The University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
Oncogene 24:2184-94. 2005..This in vitro model may recapitulate the processes underlying genomic instability in pancreatic tumours in vivo, and attests to the existence of a p53-dependent polyploidy checkpoint acting to limit the degree of polyploidization...
- Prognostic markers in resectable non-small cell lung cancer: a multivariate analysisM P Pelletier
Division of Cardiothoracic Surgery, Royal Victoria Hospital, McGill University Health Centre, Montreal, Que
Can J Surg 44:180-8. 2001..For nonsquamous cell lung carcinomas, the presence of peritumoral B lymphocytes was strongly associated with improved survival, suggesting an important role for humoral mediated immunity...
- Ploidy reductions in murine fusion-derived hepatocytesAndrew W Duncan
Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon, United States of America
PLoS Genet 5:e1000385. 2009..The generation of such daughter cells increases liver diversity, which may increase the likelihood of oncogenesis...
- Reconfirming the hybrid origin and generic status of the Iberian cyprinid complex Squalius alburnoidesM J Collares-Pereira
Universidade de Lisboa, Faculdade de Ciencias, Departamento de Biologia Animal, Centro de Biologia Ambiental, Campo Grande C2 Piso 3, Lisboa, Portugal
J Fish Biol 76:707-15. 2010..Squalius alburnoides is here defined as a complex based on the existence of a hybrid form with distinct genome combinations and ploidies and of a reconstituted nuclear non-hybrid male form also with hybrid origin.
- Infectious bursal disease virus is an icosahedral polyploid dsRNA virusDaniel Luque
Department of Structure of Macromolecules, Centro Nacional de Biotecnologia CSIC, Cantoblanco, 28049 Madrid, Spain
Proc Natl Acad Sci U S A 106:2148-52. 2009..Our results show an unprecedented replicative strategy for dsRNA viruses and suggest that birnaviruses are living viral entities encompassing numerous functional and structural characteristics of positive and negative ssRNA viruses...
- Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopesTeun W J M van Herpen
Allergy Consortium Wageningen, PO Box 16, NL 6700 AA Wageningen, The Netherlands
BMC Genomics 7:1. 2006..However, wheat gluten proteins cause celiac disease (CD) in 0.5 to 1% of the general population. Among these proteins, the alpha-gliadins contain several peptides that are associated to the disease...
- Flow cytometric and microscopic analysis of the effect of tannic acid on plant nuclei and estimation of DNA contentJoão Loureiro
Laboratory of Biotechnology and Cytomics, Department of Biology, University of Aveiro, Campus Universitario de Santiago, 3810 193 Aveiro, Portugal
Ann Bot 98:515-27. 2006..In this study, the effect of tannic acid on estimation of nuclear DNA content was evaluated in Pisum sativum and Zea mays, which were chosen as model species...
- Her-2 oncogene amplification, chromosome 17 and DNA ploidy status in synovial sarcomaZoltan Sapi
Department of Pathology, St John s Hospital, Budapest, H 1125, Hungary
Pathol Oncol Res 11:133-8. 2005..Furthermore, this may open a theoretically new treatment possibility with Trastuzumab for Her-2-amplified cases of SS...
- DNA ploidy and its clinical implications in gastric cancerHideo Baba
Department of National Kyushu Cancer Center, Fukuoka, Japan
Surgery 131:S63-70. 2002..To precisely predict the biological behavior and clinical outcome of individual cancer, it may be important to clarify the DNA profiles of cancer cells in each case...
- Association of DNA pattern of metastatic lymph node with disease free survival in patients with intraoral squamous cell carcinomaSatya N Das
Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India satya
Indian J Med Res 122:216-23. 2005..Therefore, the present study was undertaken to observe DNA pattern of primary tumours and their corresponding metastatic lymph nodes and its association with the clinicopathological parameters and prognosis...
- Modes of reproduction of the hybridogenetic fish Squalius alburnoides in the Tejo and Guadiana rivers: an approach with microsatellitesMaría E Crespo-López
Centro de Biologia Ambiental Departamento de Biologia Animal, Faculdade de Ciencias da Universidade de Lisboa, Bloco C2 3 piso, Campo Grande, 1749 016 Lisbon, Portugal
Zoology (Jena) 109:277-86. 2006..hispanica-like ancestor as the paternal ancestor of S. alburnoides...
- Nuclear DNA content, proliferative activity, and p53 expression related to clinical and histopathologic features in endometrial carcinomaCaroline Lundgren
Department of Gynaecological Oncology, Radiumhemmet, Karolinska University Hospital, S 171 76 Stockholm, Sweden
Int J Gynecol Cancer 12:110-8. 2002..The combination of DNA ploidy, MIB-1, and p53 expression was an even stronger predictor of relapse-free survival than the individual prognostic factors...
- Endoreduplication and development: rule without dividing?J Traas
Laboratoire de Biologie Cellulaire, INRA, Route de Saint Cyr, 78026 Versailles Cedex, France
Curr Opin Plant Biol 1:498-503. 1998..In Arabidopsis, the study of trichomes, leaf epidermis and hypocotyl cells sheds new light on the developmental regulation of this process, and its relation to cell expansion...
- A modified swim-up method reduces polyspermy during in vitro fertilization of porcine oocytesChi Hun Park
Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Science, Seoul National University, Seoul 151 921, Republic of Korea
Anim Reprod Sci 115:169-81. 2009..05). Our results demonstrated that the modified swim-up IVF method could reduce polyspermic penetration, and consequently produce better quality and karyotypically normal embryos in porcine IVF...
- An easier method to identify the individual genomic composition of allopolyploid complexesA Inacio
Universidade de Lisboa, Faculdade de Ciencias de Lisboa, Centro de Biologia Ambiental Departamento de Biologia Animal, Bloco C2 3 degrees Piso, 1749 16, Campo Grande Lisboa, Portugal
J Fish Biol 76:1995-2001. 2010..The method is based on a length polymorphism detected in the beta-actin gene, which serves as the basis for the development of a semi-quantitative PCR...
- Unique hybrids between the fungal pathogens Cryptococcus neoformans and Cryptococcus gattiiMarjan Bovers
CBS Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands
FEMS Yeast Res 6:599-607. 2006..Mating- and serotype-specific PCR reactions showed that the strains were MATa-serotype D/MATalpha-serotype B. This study is the first to describe naturally occurring hybrids between C. neoformans and C. gattii...
- Nuclear DNA endoreduplication and expression of the mitotic inhibitor Ccs52 associated to determinate and lupinoid nodule organogenesisAlfonso González-Sama
Institut des Sciences du Vegetal, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2355, Avenue de la Terrasse, 91198 Gif sur Yvette, France
Mol Plant Microbe Interact 19:173-80. 2006..In view of our results, Ccs52A-mediated endoreduplication appears to be a universal mechanism required for nodule cell differentiation during the establishment of nitrogen-fixing symbioses...
- Co-infection weakens selection against epistatic mutations in RNA virusesRemy Froissart
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520, USA
Genetics 168:9-19. 2004..We discuss our results in light of virus disease management and the evolutionary advantage of haploidy in biological populations...
- The influence of ploidy on the distribution of cells in chimaeric mouse blastocystsC A Everett
Department of Obstetrics and Gynaecology, University of Edinburgh, UK
Zygote 4:59-66. 1996..This early effect may underlie the restricted distribution of tetraploid cells at later stages. We have demonstrated for the first time that ploidy can influence the relative position of blastomeres in the preimplantation embryo...
- Nuclear DNA content and pathology in radically treated pancreatic carcinoma. The prognostic significance of DNA ploidy, histology and nuclear gradeM Rugge
Cattedra di Istochimica and Immunoistochimica Patologica, Università di Padova ULSS 15 Veneto, Italy
Cancer 77:459-66. 1996..Histopathology and DNA ploidy were each correlated with survival in radically treated PC to ascertain the hierarchy of their prognostic significance...
- Genetic and molecular analysis of the autosomal component of the primary sex determination signal of Drosophila melanogasterD A Barbash
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3204, USA
Genetics 141:1451-71. 1995....
- The interaction between daughterless and sex-lethal in triploids: a lethal sex-transforming maternal effect linking sex determination and dosage compensation in Drosophila melanogasterT W Cline
Dev Biol 95:260-74. 1983..The relationship of da+ and Sxl+ gene functions to those of other sex-specific lethal loci in D. melanogaster, and to sex determination mechanisms in other species, is discussed...
- DNA or cell kinetics flow cytometry analysis of 33 small gastrointestinal cancers treated by photodynamic therapyM T Foultier
Faculte de Pharmacie, Nantes, France
Cancer 73:1595-607. 1994..However, there is a lack of prognostic criteria of efficacy as in other cancer treatment...
- Statistical model for characterizing epistatic control of triploid endosperm triggered by maternal and offspring QTLsYuehua Cui
Department of Statistics, University of Florida, Gainesville, FL 32611, USA
Genet Res 86:65-75. 2005..Also, the additive effect of the offspring QTLs is better estimated than the additive effect of the maternal QTLs. The implications of our model for agricultural and evolutionary genetic research are discussed...
- Ploidy changes associated with disruption of two adjacent genes on Leishmania major chromosome 1Santiago Martinez-Calvillo
Seattle Biomedical Research Institute, 307 Westlake Ave N, Seattle, WA 98109 5219, USA
Int J Parasitol 35:419-29. 2005..Further evidence of genome plasticity in Leishmania was provided by changes in chr1 copy number that occurred during in vitro growth of wild-type LmjF promastigotes and following replacement of a single copy of LmjF01.0760...
- Entamoeba invadens: restriction of ploidy by colonic short chain fatty acidsJennifer Byers
Department of Medical Parasitology, New York University School of Medicine, New York, NY 10010, USA
Exp Parasitol 110:203-6. 2005..Axenic growth of trophozoites in the absence of SCFAs, however, appears to allow trophozoites to increase the amount of DNA per cell, which they must do during the normal encystment process...
- Ploidy controls the success of mutators and nature of mutations during budding yeast evolutionDawn A Thompson
Molecular and Cellular Biology Department, 16 Divinity Ave, Harvard University, Cambridge, MA 02138, USA
Curr Biol 16:1581-90. 2006..Mismatch repair defective and nonmutator strains were competed during adaptation to four laboratory environments (rich medium, low glucose, high salt, and a nonfermentable carbon source)...
- RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factorsSeetha V Srinivasan
Department of Cell and Cancer Biology, Vontz Center for Molecular Studies, Ohio 45267, USA
J Biol Chem 282:23867-77. 2007..Collectively, these results demonstrate that deregulated S phase control is a key mechanism by which RB-deficient cells acquire elevated ploidy...
- Molecular evidence for an ancient duplication of the entire yeast genomeK H Wolfe
Department of Genetics, University of Dublin, Trinity College, Ireland
Nature 387:708-13. 1997..Tetraploidy may have facilitated the evolution of anaerobic fermentation in Saccharomyces...
- Patterns of reproductive isolation in three angiosperm generaLeonie C Moyle
Department of Biology, Duke University, Durham, North Carolina 27708, USA
Evolution 58:1195-208. 2004..In Silene, which included six polyploid species, results suggest that changes in ploidy disrupt a simple monotonic relationship between isolation and genetic distance...
- Three different origins for apparent triploid/diploid mosaicsArt Daniel
Departments of Cytogenetics, Western Sydney Genetics Program, The Children s Hospital at Westmead, P O Box 3515, Parramatta, NSW 2124, Australia
Prenat Diagn 23:529-34. 2003..This fetus developed normally and a normal infant was born with no evidence of triploidy in newborn blood or cord blood at three months of age...
- Clinical Significance of Apoptosis in Colon CancerFrank Sinicrope; Fiscal Year: 2006..abstract_text> ..
- Aberrant Crypt Foci as a Biomarker for ChemopreventionFrank Sinicrope; Fiscal Year: 2009....
- Mechanism of Meclp in the Checkpoint ResponseGEORGE BRUSH; Fiscal Year: 2006..It is expected that these studies will provide significant insight into the molecular mechanisms underlying maintenance of the non-cancerous state under genotoxic conditions. ..
- Mechanistic Effects of Organic Selenium Against Colon CMark Nelson; Fiscal Year: 2006..abstract_text> ..
- Aneuploid Cells in the Human PlacentaHeinz Ulrich Weier; Fiscal Year: 2006..We will also have detailed information about the frequency, localization and types of aneuploid cells at the fetal-maternal interface and the effects of aneuploidy on CTB proliferation and HLA-G gene expression. ..
- BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIAJoseph Wiemels; Fiscal Year: 2006..We are ultimately working to elucidate the origin and causes of a cancer that might be preventable. [unreadable] [unreadable]..
- Cell cycle control by ORC1 and other E2F targetsMaki Asano; Fiscal Year: 2005..abstract_text> ..
- Yeast Assay for p53 Molecular Analysis in Bladder CancerRalph deVere White; Fiscal Year: 2005..The results obtained during the period of this grant will form the basis for future studies that should affect treatment strategies for this disease. ..
- Molecular Diagnosis and Prognosis of Multiple MyelomaJohn Shaughnessy; Fiscal Year: 2004..Thus, the work proposed supports the goals of an R33 project funded through PAR-01-106 (Applications of Innovative Technologies for the Molecular Analysis of Cancer). ..
- Regulation of polarized cell growth by GTPasesHay Oak Park; Fiscal Year: 2009..abstract_text> ..
- Autosomal Mutagenesis and Polycystic Kidney DiseaseMITCHELL TURKER; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- hAR Alterations and Androgen-Independent Prostate CancerRalph de Vere White; Fiscal Year: 2007..unreadable] [unreadable]..
- Prospective evaluation of IGF and IL-6 Dysregulation and Multiple MyelomaGraham A Colditz; Fiscal Year: 2010..The team is led from by Drs. Colditz and Anderson and is supported by a senior statistician (Dr. Rosner) and a study director (Dr. Birmann) who is funded, in part, through a K award. ..
- CELL NON-AUTONOMOUS MODE OF TUMOR SUPPRESSION BY BRCA1Louis Dubeau; Fiscal Year: 2009....
- Regulation of BRCA1 Function by Protein Phosphatase 1Lih Ching Hsu; Fiscal Year: 2009..Lastly, we will also identify regulators of PP1 alpha activity toward BRCA1. ..
- BAC-FISH Assays for Sensitive Karyotyping of Cancer CellsHeinz Ulrich Weier; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- ROLE OF THE P34CDC2 RELATED PITSLRE PROTEIN KINASESMark Nelson; Fiscal Year: 2007..The greatest impact will be realized in the provision of novel molecular targets for therapeutic intervention strategies. ..
- Gene silencing in mammalian cells induced by environmental exposureMITCHELL TURKER; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- Neuroblastoma Biology and TherapyGARRETT BRODEUR; Fiscal Year: 2007..Furthermore, treatment strategies developed against neuroblastoma may be useful against other tumors in children and adults that are rely on the biological pathways and are affected by these agents. ..
- FUNCTIONS OF DIFFERENT P53 MUTATIONS IN PROSTATE CANCERRalph deVere White; Fiscal Year: 2004..The results obtained during the period of this grant proposal will form the basis for future studies that should affect treatment strategies for this disease. ..
- Signal Transduction Determining Fate of Stem CellsNaohiro Terada; Fiscal Year: 2003..There will also be a poster session. The format of the Conference, and its small size, are designed to foster interactions among the 225 participants. ..
- BREAST CANCER AND FUNCTION IN AGING WOMENGraham Colditz; Fiscal Year: 2001....
- SPECTRUM OF MUTATION INDUCED BY IONIZING RADIATIONMITCHELL TURKER; Fiscal Year: 2002....
- RADIATION INDUCED THYROID CANCERHeinz Ulrich Weier; Fiscal Year: 2002..We will prepare stable cell lines carrying the oncogenic rearrangements for further characterization and distribution. Finally, we will examine the levels and localization of mRNAs with Northern and in situ hybridization analysis. ..
- AUTOIMMUNE THROMBOCYTOPENIARobert McMillan; Fiscal Year: 2002..Results of these studies will be correlated with the patients' clinical course and thrombopoietin levels. In addition, the effect of immune thrombocytopenia on the patients' quality of life will be studied. ..
- Adnesion Receptors of the Insect Immune SystemJAMES NARDI; Fiscal Year: 2003..Understanding the molecular underpinnings of the insect immune response will clearly help in understanding the fate of pathogens in the blood of insect vectors of human diseases. ..
- PROGENITORS FOR ERYTHROCYTIC & MEGAKARYOCYTIC LINEAGESWILLIAM SLAYTON; Fiscal Year: 2003..Slayton's research progress. In this rich and supportive environment, Dr. Slayton will gain the experience necessary to contribute to the understanding of the early cellular and molecular events in megakaryopoiesis. ..
- Pluripotent Stem Cell using ES Cell CytoplastNaohiro Terada; Fiscal Year: 2003..In addition to such clinical significance, the current study could provide the basis for an improved system to explore the mechanisms underlying nuclear reprogramming. ..
- WOMEN'S REPRODUCTIVE HEALTH RESEARCH CAREER DEVELOPMENTW Hogge; Fiscal Year: 2003..We believe that the organization, resources, enthusiastic young faculty and an exceptional group of senior faculty combined with resources of the WRHR Center provides an exceptional opportunity for the potential physician scientist. ..
- TELOMERASE ASSAY FOR OVARIAN CANCER DETECTIONLouis Dubeau; Fiscal Year: 2004..The potential influence of these agents on the sensitivity of testing for telomerase as a means of detecting ovarian cancer cells will be examined. ..
- ENDOTOXIN INDUCED MUCOUS CELL METAPLASIAYohannes Tesfaigzi; Fiscal Year: 2003..abstract_text> ..
- Flow Cytometry to Detect Human Tumor Cells in Body FluidAWTAR GANJU KRISHAN; Fiscal Year: 2003..3. Compare data collected from flow cytometric analysis with that obtained from cytopathology and immunocytochemistry routinely performed on these specimens for diagnostic purpose. ..
- NUTRIENTS EFFECT ON GENOTYPE IN BREAST CANCERDeborah Dillon; Fiscal Year: 2003..abstract_text> ..
- RECOMBINATION MECHANISMS IN YEAST CELL DIFFERENTIATIONJames Haber; Fiscal Year: 2006..abstract_text> ..
- SPATIAL CONTROL OF CELL POLARITY DURING YEAST BUDDINGHay Oak Park; Fiscal Year: 2003..This work will also help us to understand the mechanism of genesis of human cancer since mutations in human homologs of these yeast proteins have been found in human tumor. ..
- The Rate and Molecular Spectrum of Spontaneous MutationsMichael Lynch; Fiscal Year: 2009....
- PET IN MULTIMODALITY THERAPY FOR ESOPHAGEAL CANCEREdward Levine; Fiscal Year: 2002..We plan to correlate the PET findings with endoscopic ultrasound (EUS), and spiral CT imaging to pathologic findings from resected specimens. ..
- Gene Silencing in Cancer--A Model SystemMITCHELL TURKER; Fiscal Year: 2003..The demonstration of each step of a multistep silencing pathway, which is currently undefined, will provide novel insight into this aberrant process in malignant cells. ..
- CONFOCAL HISTOPATHOLOGY OF CONTACT DERMATITIS IN VIVOSalvador Gonzalez; Fiscal Year: 2002..We also expect that our results may ultimately translate into more rational and effective care for patients with this common and frequently disabling problem. ..
- S. Cerevisiae Emergence of an Opportunistic PathogenJOHN MCCUSKER; Fiscal Year: 2009..cerevisiae population both phenotypically, for virulence and virulence-associated traits, and genotypically, for virulence-related genes. ..
- Myoglobin as an indicator of hpoxia toleranceSTEPHEN KINSEY; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Meningioma: Risk Factors and Quality of LifeJOSEPH LEO WIEMELS; Fiscal Year: 2010..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
- Conference on Mammalian Gametogenesis & EmbryogenesisPatricia Hunt; Fiscal Year: 2002..A particularly important aspect of the Gordon Conference setting is the blending of young and established investigators to promote exchanges that will generate new ideas and foster new collaborations in the field. ..
- GENETIC DIVERSITY AND COMPLEX TRAITS IN S CEREVISIAEJOHN MCCUSKER; Fiscal Year: 2002..the development of S. cerevisiae as genetically manipulable model for the pathogenic fungi and as a host for the interspecific reconstitution of fungal virulence. ..
- ANALYSIS OF GENETICALLY & ENVIRONMENTALLY OVERLAPPING YEAST QUANTITATIVE TRAITSJohn H McCusker; Fiscal Year: 2010..Therefore, an improved understanding of quantitative traits will aid our understanding of how a harmless commensal/saprophytic yeast can become an opportunistic pathogen. ..
- GENETIC CONTROL OF MEIOTIC CHROMOSOME SEGREGATIONPatricia Hunt; Fiscal Year: 2009..The combined data from these studies will allow us to understand the control of recombination In mammals and how the events of prophase influence meiotic chromosome segregation. ..
- Mechanisms of In Vivo Cell FusionAndrew Duncan; Fiscal Year: 2008..Aim 2: To determine relevant properties of fusion-derived hepatocytes. Aim 3: To enhance in vivo cell fusion by expression of fusogenic viral envelope proteins. [unreadable] [unreadable] [unreadable]..
- PHASE VARIATION IN SACCHAROMYCES CEREVISIAEJOHN MCCUSKER; Fiscal Year: 2003..The PHI genes will be introduced to the non-phase variable laboratory strain, 288c, in efforts to reconstruct phase variation. ..
- Fungal-specific drug targets: static vs. cidal starvation & toxic intermediatesJOHN MCCUSKER; Fiscal Year: 2008..The identification of fungicidal antifungal drugs, which is a long-term goal, will greatly improve human health. [unreadable] [unreadable] [unreadable]..
- CHROMOSOME COUNTING MECHANISMS IN SEX DETERMINIATIONJames Erickson; Fiscal Year: 2006..Detailed understanding of the mechanics and circuitry underlying the process will prove even more instructive. ..
- Molecular Basis of Young Onset Colorectal CancerLisa Boardman; Fiscal Year: 2006..Following achievement of these goals, I am confident that I will be ready to continue my career as a successful independent investigator committed to colerectal cancer prevention and control. ..
- The Mouse Oocyte: A New Assay for Reproductive ToxinsPatricia Hunt; Fiscal Year: 2003..In addition, because the observed meiotic disruption (congression failure) is an age-related defect in human oocytes, the data may provide important insight to human age-related aneuploidy. ..