ploidies

Summary

Summary: The degree of replication of the chromosome set in the karyotype.

Top Publications

  1. ncbi Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling
    Larissa Lordier
    INSERM, U790, Villejuif, France
    Blood 112:3164-74. 2008
  2. ncbi Ploidy regulation of gene expression
    T Galitski
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 285:251-4. 1999
  3. pmc Genome size variation and species relationships in Hieracium sub-genus Pilosella (Asteraceae) as inferred by flow cytometry
    Jan Suda
    Department of Botany, Faculty of Science, Charles University in Prague, Benatska 2, CZ 128 01 Prague, Czech Republic
    Ann Bot 100:1323-35. 2007
  4. ncbi Prognostic factors in surgical stage I endometrial carcinoma
    Caroline Lundgren
    Department of Gynaecologic Oncology, Radiumhemmet Karolinska University Hospital, Stockholm, Sweden
    Acta Oncol 43:49-56. 2004
  5. ncbi Transcriptome shock after interspecific hybridization in senecio is ameliorated by genome duplication
    Matthew J Hegarty
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, United Kingdom
    Curr Biol 16:1652-9. 2006
  6. ncbi Hierarchical classification of switchgrass genotypes using SSR and chloroplast sequences: ecotypes, ploidies, gene pools, and cultivars
    J E Zalapa
    USDA ARS, Vegetable Crops Research Unit, Department of Horticulture, University of Wisconsin, Madison, WI, USA
    Theor Appl Genet 122:805-17. 2011
  7. ncbi Live birth after polar body array comparative genomic hybridization prediction of embryo ploidy-the future of IVF?
    Simon Fishel
    CARE Fertility, John Webster House, 6 Lawrence Drive, Nottingham Business Park, Nottingham NG8 6PZ, United Kingdom
    Fertil Steril 93:1006.e7-1006.e10. 2010
  8. ncbi Gene expression analysis at the intersection of ploidy and hybridity in maize
    Nicole C Riddle
    Division of Biological Sciences, University of Missouri, 117 Tucker Hall, Columbia, MO 65211, USA
    Theor Appl Genet 120:341-53. 2010
  9. ncbi Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic setting
    Elisabeth Wik
    Institute of Clinical Medicine, University of Bergen, and Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
    Am J Obstet Gynecol 201:603.e1-7. 2009
  10. pmc FZR2/CCS52A1 expression is a determinant of endoreduplication and cell expansion in Arabidopsis
    Zachary Larson-Rabin
    University of Wisconsin, Laboratory of Genetics, Department of Horticulture, Madison, Wisconsin 53706, USA
    Plant Physiol 149:874-84. 2009

Research Grants

  1. Clinical Significance of Apoptosis in Colon Cancer
    Frank Sinicrope; Fiscal Year: 2006
  2. Aberrant Crypt Foci as a Biomarker for Chemoprevention
    Frank Sinicrope; Fiscal Year: 2009
  3. Mechanism of Meclp in the Checkpoint Response
    GEORGE BRUSH; Fiscal Year: 2006
  4. Mechanistic Effects of Organic Selenium Against Colon C
    Mark Nelson; Fiscal Year: 2006
  5. Aneuploid Cells in the Human Placenta
    Heinz Ulrich Weier; Fiscal Year: 2006
  6. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2006
  7. Cell cycle control by ORC1 and other E2F targets
    Maki Asano; Fiscal Year: 2005
  8. Yeast Assay for p53 Molecular Analysis in Bladder Cancer
    Ralph deVere White; Fiscal Year: 2005
  9. Molecular Diagnosis and Prognosis of Multiple Myeloma
    John Shaughnessy; Fiscal Year: 2004
  10. Regulation of polarized cell growth by GTPases
    Hay Oak Park; Fiscal Year: 2009

Detail Information

Publications253 found, 100 shown here

  1. ncbi Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling
    Larissa Lordier
    INSERM, U790, Villejuif, France
    Blood 112:3164-74. 2008
    ..Our results suggest that the late failure of cytokinesis responsible for the endomitotic process is related to a partial defect in the Rho/Rock pathway activation...
  2. ncbi Ploidy regulation of gene expression
    T Galitski
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 285:251-4. 1999
    ..Ploidy-dependent repression of some G1 cyclins can explain the greater cell size associated with higher ploidies, and suggests ploidy-dependent modifications of cell cycle progression...
  3. pmc Genome size variation and species relationships in Hieracium sub-genus Pilosella (Asteraceae) as inferred by flow cytometry
    Jan Suda
    Department of Botany, Faculty of Science, Charles University in Prague, Benatska 2, CZ 128 01 Prague, Czech Republic
    Ann Bot 100:1323-35. 2007
    ..In this study, genome size variation was investigated in a representative set of Central European hawkweeds in order to assess the value of such a data set for species delineation and inference of evolutionary relationships...
  4. ncbi Prognostic factors in surgical stage I endometrial carcinoma
    Caroline Lundgren
    Department of Gynaecologic Oncology, Radiumhemmet Karolinska University Hospital, Stockholm, Sweden
    Acta Oncol 43:49-56. 2004
    ..001, p = 0.004), whereas only ploidy was significant in the endometrioid subgroup (p = 0.001). DNA ploidy was the strongest predictor of relapse-free survival and the only independent prognostic factor in the endometrioid subgroup...
  5. ncbi Transcriptome shock after interspecific hybridization in senecio is ameliorated by genome duplication
    Matthew J Hegarty
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, United Kingdom
    Curr Biol 16:1652-9. 2006
    ..cambrensis and this altered expression pattern is maintained in subsequent generations. These findings indicate that hybridization and polyploidization have immediate yet distinct effects on large-scale patterns of gene expression...
  6. ncbi Hierarchical classification of switchgrass genotypes using SSR and chloroplast sequences: ecotypes, ploidies, gene pools, and cultivars
    J E Zalapa
    USDA ARS, Vegetable Crops Research Unit, Department of Horticulture, University of Wisconsin, Madison, WI, USA
    Theor Appl Genet 122:805-17. 2011
    ..This classification system is the first step toward developing switchgrass complementary gene pools that can be expected to provide a significant heterotic increase in biomass yield...
  7. ncbi Live birth after polar body array comparative genomic hybridization prediction of embryo ploidy-the future of IVF?
    Simon Fishel
    CARE Fertility, John Webster House, 6 Lawrence Drive, Nottingham Business Park, Nottingham NG8 6PZ, United Kingdom
    Fertil Steril 93:1006.e7-1006.e10. 2010
    ....
  8. ncbi Gene expression analysis at the intersection of ploidy and hybridity in maize
    Nicole C Riddle
    Division of Biological Sciences, University of Missouri, 117 Tucker Hall, Columbia, MO 65211, USA
    Theor Appl Genet 120:341-53. 2010
    ..Overall, we find that gene expression trends mirror observations from the phenotypic studies; however, obvious mechanistic connections remain unknown...
  9. ncbi Deoxyribonucleic acid ploidy in endometrial carcinoma: a reproducible and valid prognostic marker in a routine diagnostic setting
    Elisabeth Wik
    Institute of Clinical Medicine, University of Bergen, and Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway
    Am J Obstet Gynecol 201:603.e1-7. 2009
    ..The objective of the study was to investigate the prognostic impact of deoxyribonucleic acid (DNA) ploidy in endometrial carcinoma in a routine diagnostic series as compared with a research series...
  10. pmc FZR2/CCS52A1 expression is a determinant of endoreduplication and cell expansion in Arabidopsis
    Zachary Larson-Rabin
    University of Wisconsin, Laboratory of Genetics, Department of Horticulture, Madison, Wisconsin 53706, USA
    Plant Physiol 149:874-84. 2009
    ..Our data, which suggest that reduced cell size can be compensated by increased cell proliferation to allow normal leaf morphology, are discussed with respect to the so-called compensation mechanism of plant development...
  11. pmc BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis
    Christian Breuer
    Department of Cell and Developmental Biology, John Ines Centre, Norwich NR4 7UH, United Kingdom
    Plant Cell 19:3655-68. 2007
    ....
  12. pmc Apomixis and reticulate evolution in the Asplenium monanthes fern complex
    Robert J Dyer
    Department of Botany, Natural History Museum, London, UK
    Ann Bot 110:1515-29. 2012
    ..The purpose of this study was to elucidate the phylogenetic relationships in the A. monanthes complex and to investigate the occurrence and evolution of apomixis within this group...
  13. ncbi Interrelation between polyploidization and megakaryocyte differentiation: a gene profiling approach
    Hana Raslova
    INSERM Unité 790, Institut Gustave Roussy, 1 rue Camille Desmoulins, 94805 Villejuif, France
    Blood 109:3225-34. 2007
    ..Together, these results suggest that MK polyploidization per se does not regulate gene expression but is intrinsically included in the differentiation process...
  14. pmc Intraspecific DNA content variability in Festuca pallens on different geographical scales and ploidy levels
    Petr Smarda
    Masaryk University, Faculty of Science, Institute of Botany and Zoology, Kotlarska 2, CZ 611 37 Brno, Czech Republic
    Ann Bot 98:665-78. 2006
    ....
  15. pmc The gene balance hypothesis: from classical genetics to modern genomics
    James A Birchler
    Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA
    Plant Cell 19:395-402. 2007
  16. pmc The origin, evolution and proposed stabilization of the terms 'genome size' and 'C-value' to describe nuclear DNA contents
    Johann Greilhuber
    Institute of Botany and Botanical Garden of the University of Vienna, Austria
    Ann Bot 95:255-60. 2005
    ..Reconsideration of the terminology is required...
  17. pmc Meiotic S-phase damage activates recombination without checkpoint arrest
    Daniel G Pankratz
    Molecular and Cell Biology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Mol Biol Cell 16:1651-60. 2005
    ..Our results suggest that fission yeast meiosis is exceptionally tolerant of DNA damage, and that some forms of spontaneous S-phase damage can be repaired by recombination without activating checkpoint arrest...
  18. ncbi Vascular smooth muscle polyploidization as a biomarker for aging and its impact on differential gene expression
    Matthew R Jones
    Department of Biochemistry, Boston University, Boston, Massachusetts 02118, USA
    J Biol Chem 279:5306-13. 2004
    ..Our study is the first to describe aortic ploidy level as a biomarker for aging and to indicate that changes associated with increased DNA content per cell may selectively suppress the expression of specific genes...
  19. ncbi Production and characterization of amphiploids of Aegilops kotschyi and Ae. biuncialis with Secale cereale, and of backcross hybrids of Ae. biuncialis x S. cereale amphiploids with 2x and 4x S. cereale
    Barbara Wojciechowska
    Institute of Plant Genetics, Polish Academy of Sciences, Strzeszynska 34, 60 479 Poznan, Poland
    J Appl Genet 46:157-61. 2005
    ..The BC1 plants (2n = 4x = 28 and 2n = 5x = 35, respectively) were phenotypically intermediate between the parents and vigorous in vegetative growth. Some seeds were obtained only from the 35-chromosome BC1 hybrids...
  20. ncbi Large-scale genomic instability predicts long-term outcome for women with invasive stage I ovarian cancer
    G B Kristensen
    Department of Gynecologic Oncology and Department of Pathology, The Norwegian Radium Hospital, Montebello, Oslo, Norway
    Ann Oncol 14:1494-500. 2003
    ..The objective was to evaluate the value of DNA ploidy using high-resolution image cytometry in predicting long-term survival of patients with early ovarian cancer...
  21. ncbi Six monophyletic lineages identified within Cryptococcus neoformans and Cryptococcus gattii by multi-locus sequence typing
    M Bovers
    CBS Fungal Biodiversity Centre, Utrecht, The Netherlands
    Fungal Genet Biol 45:400-21. 2008
    ..In addition, four monophyletic lineages corresponding to the previously described genotypic groups were consistently found within C. gattii, indicating that these lineages should be considered different taxa as well...
  22. pmc Aneuploidy and genetic variation in the Arabidopsis thaliana triploid response
    Isabelle M Henry
    Department of Biology, University of Washington, Seattle, Washington 98195 5325, USA
    Genetics 170:1979-88. 2005
    ..Thus, genetic variation was subject to selection contingent on the final ploidy and possibly acting during the protracted aneuploid phase...
  23. ncbi Different ploidy levels of megakaryocytes generated from peripheral or cord blood CD34+ cells are correlated with different levels of platelet release
    Gianfranco Mattia
    Department of Clinical Biochemistry, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161, Rome, Italy
    Blood 99:888-97. 2002
    ..The data indicate the inability of the CB-MKs to progress in the endomitotic process and a direct correlation between DNA content and platelet production...
  24. pmc Somatic tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor
    Sandra M Morillo
    Department of Molecular, Cellular and Developmental Neurobiology, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Proc Natl Acad Sci U S A 107:109-14. 2010
    ..Thus, a developmental program leading to somatic tetraploidy in specific retinal neurons exists in vertebrates. This program might occur in other vertebrate neurons during normal or pathological situations...
  25. pmc A chromosome bin map of 16,000 expressed sequence tag loci and distribution of genes among the three genomes of polyploid wheat
    L L Qi
    Department of Plant Pathology, Wheat Genetics Resource Center, Kansas State University, Manhattan, Kansas 66506 5502, USA
    Genetics 168:701-12. 2004
    ....
  26. pmc Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast
    C S Chan
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Genetics 135:677-91. 1993
    ..Molecular cloning and genetic mapping show that IPL1 is a newly identified gene, whereas IPL2 is allelic to BEM2, which is required for normal bud growth...
  27. ncbi Inhibition of the aurora kinases suppresses in vitro NT2-D1 cell growth and tumorigenicity
    Salvatore Ulisse
    Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy
    J Endocrinol 204:135-42. 2010
    ..In conclusion, the above findings demonstrate that inhibition of aurora kinase activity is effective in reducing in vitro growth and tumorigenicity of NT2-D1 cells, and indicate its potential therapeutic value for TGCT treatment...
  28. pmc Chromosome sorting in tetraploid wheat and its potential for genome analysis
    Marie Kubaláková
    Laboratory of Molecular Cytogenetics and Cytometry, Institute of Experimental Botany, Olomouc, Czech Republic
    Genetics 170:823-9. 2005
    ..This study considerably expands the potential of flow cytogenetics for use in wheat genomics and opens the possibility of sequencing the genome of this important crop one chromosome arm at a time...
  29. ncbi Homozygosity at the MTL locus in clinical strains of Candida albicans: karyotypic rearrangements and tetraploid formation
    Melanie Legrand
    Department of Genetics, Cell Biology, and Development, University of Minnesota, 321 Church St SE, Minneapolis, MN 55455, USA
    Mol Microbiol 52:1451-62. 2004
    ..Furthermore, as clinical strains can mate and form tetraploids, mating and marker exchange are likely to be a significant part of the life cycle of C. albicans in vivo...
  30. ncbi Genetic variation for the response to ploidy change in Zea mays L
    Nicole C Riddle
    Division of Biological Sciences, University of Missouri Columbia, 117 Tucker Hall, Columbia, MO 65211 7400, USA
    Theor Appl Genet 114:101-11. 2006
    ..The other source is genotype specific and results in a response to ploidy change that varies among inbred lines. This finding demonstrates the existence of genetic variation for the morphological response to ploidy change in Zea mays...
  31. ncbi Phenotypic consequences of genetic variation in a gynogenetic complex of Phoxinus eos-neogaeus clonal fish (Pisces: Cyprinidae) inhabiting a heterogeneous environment
    Matthew R Doeringsfeld
    Department of Biology, University of North Dakota, Grand Forks, North Dakota 58202 9019, USA
    Evolution 58:1261-73. 2004
    ....
  32. ncbi Prospective multicenter validation confirms the prognostic superiority of the endometrial carcinoma prognostic index in international Federation of gynecology and obstetrics stage 1 and 2 endometrial carcinoma
    Jan P A Baak
    Department of Pathology, Rogaland Central Hospital, Stavanger, Norway
    J Clin Oncol 21:4214-21. 2003
    ..To validate the prognostic value of the endometrial carcinoma prognostic index (ECPI; combined myometrium invasion, flow cytometric DNA ploidy, and morphometric mean shortest nuclear axis [MSNA]) versus classic prognosticators...
  33. ncbi Core classification of lung cancer: correlating nuclear size and mitoses with ploidy and clinicopathological parameters
    Iver Petersen
    Institute of Pathology, Universitatsklinikum Jena, Jena, Germany
    Lung Cancer 65:312-8. 2009
    ..e. 2c deviation index and 5c exceeding rate, were predictors of poor survival in NSCLC patients. As a complement to histologic tumour diagnosis the core classification should help to better stratify cancer subtypes...
  34. ncbi Developmental potential of mouse tetraploid cells in diploid <--> tetraploid chimeric embryos
    Yuji Goto
    Division of Bioscience, Graduate School of Environmental Earth Science and Research Center for Molecular Genetics, Hokkaido University, Japan
    Int J Dev Biol 46:741-5. 2002
    ..The complete lack of 4n cell contribution to chimeras produced by the standard procedure is therefore attributed to the initial low proportion of 4n cells allocated to epiblast and their severe elimination from embryonic tissues...
  35. pmc Control of DNA replication and chromosome ploidy by geminin and cyclin A
    Ivailo S Mihaylov
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Mol Cell Biol 22:1868-80. 2002
    ..Together, our studies indicate that both cyclin A and geminin are required for the suppression of overreplication and for genome stability in Drosophila cells...
  36. pmc Chromosome numbers and genome size variation in Indian species of Curcuma (Zingiberaceae)
    Jana Leong-Skornicková
    Department of Botany, Charles University in Prague, Benatska 2, Prague 2, CZ 12801, Czech Republic
    Ann Bot 100:505-26. 2007
    ..In the present study, an investigation was made of chromosomal and genome size variation in the majority of Curcuma species from the Indian subcontinent, and an assessment was made of the value of these data for taxonomic purposes...
  37. pmc An allometric relationship between mitotic spindle width, spindle length, and ploidy in Caenorhabditis elegans embryos
    Yuki Hara
    Cell Architecture Laboratory, Structural Biology Center, National Institute of Genetics, Yata 1111, Mishima, Shizuoka 411 8540, Japan
    Mol Biol Cell 24:1411-9. 2013
    ..On the basis of this equation, we propose a force-balance model to determine the spindle width...
  38. pmc Nuclear DNA C-values in 30 species double the familial representation in pteridophytes
    Renate Obermayer
    Jodrell Laboratory, Royal Botanic Gardens, Richmond, Surrey, UK
    Ann Bot 90:209-17. 2002
    ..7 pg in Psilotum nudum var. gasa. Superimposing C-value data onto a robust phylogeny of pteridophytes suggests some possible trends in C-value evolution and highlights areas for future work...
  39. ncbi Scp160p, a new yeast protein associated with the nuclear membrane and the endoplasmic reticulum, is necessary for maintenance of exact ploidy
    U Wintersberger
    Department of Molecular Genetics, University of Vienna, Austria
    Yeast 11:929-44. 1995
    ..Taken together the data suggest that the Scp160 protein is required during cell division for faithful partitioning of the ER-nuclear envelope membranes which in S. cerevisiae enclose the duplicated chromosomes...
  40. pmc Cytoplasmic and genomic effects on meiotic pairing in Brassica hybrids and allotetraploids from pair crosses of three cultivated diploids
    Cheng Cui
    National Key Laboratory of Crop Genetic Improvement, National Center of Crop Molecular Breeding Technology, National Center of Oil Crop Improvement Wuhan, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
    Genetics 191:725-38. 2012
    ..Our results highlight the specific roles of the cytoplasm and genome to the chromosomal behaviors of hybrids and allopolyploids...
  41. pmc Prognostic importance of DNA ploidy and DNA index in stage I and II endometrioid adenocarcinoma of the endometrium
    M Pradhan
    Institute for Medical Informatics, Department of Pathology, Oslo University Hospital, Oslo, Norway
    Ann Oncol 23:1178-84. 2012
    ..We evaluated the prognostic importance of DNA ploidy in stage I and II endometrioid adenocarcinoma (EAC) of the endometrium with a focus on DNA index...
  42. ncbi DNA ploidy analysis as an adjunct for the detection of relapse in B-lineage acute lymphoblastic leukemia
    Barton Kenney
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520 8035, USA
    Leuk Lymphoma 49:42-8. 2008
    ..These results suggest that it may be beneficial to perform ploidy analysis as an adjunct to flow immunophenotyping in following patients with B-lineage ALL who demonstrate aneuploidy at diagnosis...
  43. ncbi DNA ploidy heterogeneity in endometrial carcinoma: comparison between curettage and hysterectomy specimens
    Manohar Pradhan
    Department of Pathology, Oslo University Hospital, University of Oslo, Oslo, Norway
    Int J Gynecol Pathol 29:572-8. 2010
    ..The difference observed, which we believe reflects the intratumoral heterogeneity, should be taken into account when applying DNA ploidy to endometrial carcinoma specimens...
  44. pmc Evaluation of DNA ploidy in relation with established prognostic factors in patients with locally advanced (unresectable) or metastatic pancreatic adenocarcinoma: a retrospective analysis
    Nikolas Tsavaris
    Oncology Unit, Department of Pathophysiology, Laikon General Hospital, Athens University School of Medicine, Athens, Greece
    BMC Cancer 9:264. 2009
    ..The aim of this study was to evaluate the prognostic significance of DNA ploidy in relation with established clinical and laboratory variables in such patients...
  45. ncbi Molecular and histopathologic predictors of distant failure in endometrial cancer
    Andrea Mariani
    Department of Obstetrics and Gynecology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Cancer Detect Prev 27:434-41. 2003
    ..01). Thus, locoregional therapy may be insufficient when at least one of these predictors is present...
  46. pmc Flow cytometric analysis of DNA ploidy and S-phase fraction from prostatic carcinomas: implications for prognosis and response to endocrine therapy
    T Visakorpi
    Department of Clinical Chemistry, Tampere University Hospital, Finland
    Br J Cancer 64:578-82. 1991
    ..SPF was also the best predictor of progression free survival in patients treated hormonally. In conclusion, detection of high SPF in prostate cancer may indicate lack of hormonal responsiveness and poor prognosis...
  47. ncbi Phenotypic and cytologic studies of lymphoid cells and monocytes in primary culture of porcine bone marrow during infection of African swine fever virus
    E M Karalova
    Laboratory of Cell Biology, Institute of Molecular Biology NAS RA, PO Box 0014, Yerevan, Armenia
    In Vitro Cell Dev Biol Anim 47:200-4. 2011
    ..The cytophotometry of main and additional nuclei showed that DNA content didn't exceed diploid standard which indicates that the additional nuclei were consequence of fragmentation of nuclei in lymphocytes...
  48. ncbi DNA ploidy is an independent prognostic indicator of overall survival in stage I endometrial endometrioid carcinoma
    Markku Santala
    Department of Obstetrics and Gynecology, University of Oulu, Finland
    Anticancer Res 23:5191-6. 2003
    ..The current retrospective follow-up study aimed to evaluate DNA ploidy, S-phase fraction and preoperative serum CA 125 level as prognostic factors of endometrial endometrioid adenocarcinoma...
  49. ncbi Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells
    M Tatsuka
    Department of Regulatory Radiobiology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
    Cancer Res 58:4811-6. 1998
    ..Thus, defects of pathways essential for mitotic regulation are important during human cancer development...
  50. ncbi DNA ploidy, E-cadherin, beta-catenin expression and their clinicopathologic significance in imprints of non-small cell lung cancer
    George Chelidonis
    1st Pathology Department and Cytology Unit, Medical School, Athens University, Athens, Greece
    Anal Quant Cytol Histol 31:332-9. 2009
    ..To evaluate, in imprints of resected non-small cell lung cancers (NSCLCs), the relationship between DNA ploidy and E-cadherin/beta-catenin expression with classical prognostic factors...
  51. ncbi DNA-ploidy in advanced gastric carcinoma is less heterogeneous than in early gastric cancer
    Maria Chiara Osterheld
    Institut Universitaire de Pathologie, Rue du Bugnon25, 1011 Lausanne, Switzerland
    Cell Oncol 26:21-9. 2004
    ....
  52. ncbi Long-term genome diploidization in allopolyploid Nicotiana section Repandae (Solanaceae)
    James J Clarkson
    Jodrell Laboratory, Royal Botanic Gasrdens, Kew, Richmond, Surrey, TW9 3DS, UK
    New Phytol 168:241-52. 2005
    ..In Nicotiana, 4.5 Myr of allopolyploid evolution renders genomic in situ hybridization (GISH) unsuitable for the complete resolution of parental genomes...
  53. ncbi The role of DNA ploidy in postoperative management of stage I endometrial cancer
    G Mangili
    Division of Gynecology and Obstetrics, IRCCS San Raffaele Hospital, University of Milan, Milan, Italy
    Ann Oncol 19:1278-83. 2008
    ..Decision is on the basis of traditional prognostic factors. We report our experience in which ploidy has found to play a role in clinical practice since 1999...
  54. pmc Gross genomic damage measured by DNA image cytometry independently predicts gastric cancer patient survival
    J A M Belien
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Br J Cancer 101:1011-8. 2009
    ..The aim of our study was to compare the DNA ploidy status measured using FCM-DNA and ICM-DNA in gastric cancer and to evaluate its association with clinicopathological variables...
  55. pmc Euploidy in somatic cells from R6/2 transgenic Huntington's disease mice
    Asa Petersen
    Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden
    BMC Cell Biol 6:34. 2005
    ..Aneuploidy is normally a feature closely connected to neoplastic disease. To further explore this unexpected aspect of HD, we studied cultures derived from 6- and 12-week-old R6/2 fibroblasts, skeletal muscle cells, and liver cells...
  56. pmc Implications of hybridisation and cytotypic differentiation in speciation assessed by AFLP and plastid haplotypes--a case study of Potentilla alpicola La Soie
    Juraj Paule
    Department of Biodiversity and Plant Systematics, Centre for Organismal Studies Heidelberg, Heidelberg University, Heidelberg, Germany
    BMC Evol Biol 12:132. 2012
    ..In the present study, the alpine taxon Potentilla alpicola has been chosen in order to study its presumed hybrid origin, identify underlying evolutionary processes and infer the discreteness or taxonomic value of hybrid forms...
  57. ncbi Prognostic impact of Deoxyribonucleic acid (DNA) image analysis cytometry and immunohistochemical expression of Ki67 in surgically resected non-small cell lung cancers
    Nicoletta F Maounis
    Department of Cytology, Sismanoglion General Hospital, 1 Sismanogliou Str, Athens 151 26, Greece
    Cancer Detect Prev 30:507-14. 2006
    ..The aim of the present study was to evaluate the prognostic significance of DNA ploidy and Ki67 expression in non-small cell lung carcinoma (NSCLC)...
  58. ncbi Significance of morphometric, DNA cytometric features, and other prognostic markers on survival of endometrial cancer patients in northern Norway
    A Ørbo
    Department of Pathology, Institute of Medical Biology, Faculty of Medicine, University Hospital of Tromsø, N 9037 Tromsø, Norway
    Int J Gynecol Cancer 12:49-56. 2002
    ....
  59. ncbi Identification of intergenomic translocations involving wheat, Hordeum vulgare and Hordeum chilense chromosomes by FISH
    P Prieto
    Instituto de Agricultura Sostenible CSIC, Apdo 4084, 14080 Cordoba, Spain
    Hereditas 135:171-4. 2001
    ..Frequencies of plants containing different kinds of intergenomic translocations between chromosome arms are presented. These lines can be useful for introgressing into tritordeum characters of interest from H. vulgare...
  60. ncbi Adenocarcinoma corpus uteri stage I-II: results of a treatment programme based upon cytometry
    Bengt Lindahl
    Department of Obstetrics and Gynaecology University Hospital Lund, Sweden
    Anticancer Res 29:4731-5. 2009
    ..We therefore recommend future research to be directed toward cytostatics as an alternative adjuvant treatment...
  61. pmc Direct visualization of the endomitotic cell cycle in living megakaryocytes: differential patterns in low and high ploidy cells
    Nicholas Papadantonakis
    Department of Biochemistry, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Cell Cycle 7:2352-6. 2008
    ..This is the first study to document chromosomal segregation patterns during endomitosis ex vivo and to indicate their potential differential regulation in low and high ploidy cells...
  62. pmc Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage
    Robert J D Reid
    Columbia University Medical Center, Department of Genetics and Development, New York, NY 10032, USA
    Genome Res 21:477-86. 2011
    ..These findings demonstrate the utility of the SPA technique to introduce plasmids into the haploid gene-disruption library to discover new interacting pathways...
  63. ncbi A simple method for the calculation of microsatellite genotype distances irrespective of ploidy level
    Ruzica Bruvo
    Department of Evolutionary Biology, Institute for Animal Evolution and Ecology, Westphalian Wilhelms University, Hüfferstr 1, 48149 Munster, Germany
    Mol Ecol 13:2101-6. 2004
    ..An illustration is given using data from the planarian flatworm Schmidtea polychroa (Platyhelminthes)...
  64. pmc Comparative sequence analysis of MONOCULM1-orthologous regions in 14 Oryza genomes
    Fei Lu
    State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Proc Natl Acad Sci U S A 106:2071-6. 2009
    ..6 and 0.4 Mya, respectively. In allotetraploids, pseudogenization of duplicated genes was common, caused by large deletions, small frame-shifting insertions/deletions, or nonsense mutations...
  65. pmc Genome Alteration Print (GAP): a tool to visualize and mine complex cancer genomic profiles obtained by SNP arrays
    Tatiana Popova
    Centre de Recherche, Institut Curie, 26 Rue d Ulm, Paris, 75248, France
    Genome Biol 10:R128. 2009
    ..Assignments were verified by DNA indexes of primary tumors and karyotypes of cell lines. The method performs well even for poor-quality data, low tumor content, and highly rearranged tumor genomes...
  66. pmc Entamoeba shows reversible variation in ploidy under different growth conditions and between life cycle phases
    Chandrama Mukherjee
    Department of Biochemistry, Bose Institute, Kolkata, India
    PLoS Negl Trop Dis 2:e281. 2008
    ..Our studies demonstrate the inherent plasticity and dynamic nature of the Entamoeba genome in at least two species...
  67. ncbi Chromatin assembly factor CAF-1 is required for cellular differentiation during plant development
    Vivien Exner
    Institute of Plant Sciences and Basel Zurich Plant Science Center, ETH Zurich, 8092 Zurich, Switzerland
    Development 133:4163-72. 2006
    ..These results reveal that the functions of FAS1, FAS2 and MSI1 are not restricted to meristems, but are also needed to control genome replication at multiple steps of development...
  68. ncbi A prospective population-based management program including primary surgery and postoperative risk assessment by means of DNA ploidy and histopathology. Adjuvant radiotherapy is not necessary for the majority of patients with FIGO stage I-II endometrial c
    T Hogberg
    Department of Gynecologic Oncology, University Hospital, Linkoping, Sweden
    Int J Gynecol Cancer 14:437-50. 2004
    ..Thus, effective systemic treatments need to be developed. Low-risk patients, constituting the majority (84%) of the patients, can be safely treated by surgery only...
  69. ncbi Spontaneous deletions and reciprocal translocations in Saccharomyces cerevisiae: influence of ploidy
    Yves Tourrette
    UMR 7156 Université Louis Pasteur CNRS, Genetique Moleculaire, Genomique, Microbiologie, Département Microorganismes, Génomes, Environnement, Strasbourg, France
    Mol Microbiol 64:382-95. 2007
    ..After discussing the differences between the haploid and diploid levels, some mechanisms possibly involved in chromosome shortening and arm exchange are suggested...
  70. ncbi DNA ploidy and S-phase fraction as prognostic factors in surgically resected gastric carcinoma: a 7-year prospective study
    Gabriella Nesi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Anticancer Res 27:4435-41. 2007
    ..DNA ploidy and S-phase fraction (SPF) measured by DNA flow cytometry (FC) have been previously shown to correlate with several clinicopathological variables in several types of tumours...
  71. ncbi p53 deficiency exacerbates pleiotropic mitotic defects, changes in nuclearity and polyploidy in transdifferentiating pancreatic acinar cells
    Nathalie Sphyris
    Division of Pathology, School of Molecular and Clinical Medicine, The University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
    Oncogene 24:2184-94. 2005
    ..This in vitro model may recapitulate the processes underlying genomic instability in pancreatic tumours in vivo, and attests to the existence of a p53-dependent polyploidy checkpoint acting to limit the degree of polyploidization...
  72. pmc Prognostic markers in resectable non-small cell lung cancer: a multivariate analysis
    M P Pelletier
    Division of Cardiothoracic Surgery, Royal Victoria Hospital, McGill University Health Centre, Montreal, Que
    Can J Surg 44:180-8. 2001
    ..For nonsquamous cell lung carcinomas, the presence of peritumoral B lymphocytes was strongly associated with improved survival, suggesting an important role for humoral mediated immunity...
  73. pmc Ploidy reductions in murine fusion-derived hepatocytes
    Andrew W Duncan
    Oregon Stem Cell Center, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS Genet 5:e1000385. 2009
    ..The generation of such daughter cells increases liver diversity, which may increase the likelihood of oncogenesis...
  74. ncbi Reconfirming the hybrid origin and generic status of the Iberian cyprinid complex Squalius alburnoides
    M J Collares-Pereira
    Universidade de Lisboa, Faculdade de Ciencias, Departamento de Biologia Animal, Centro de Biologia Ambiental, Campo Grande C2 Piso 3, Lisboa, Portugal
    J Fish Biol 76:707-15. 2010
    ..Squalius alburnoides is here defined as a complex based on the existence of a hybrid form with distinct genome combinations and ploidies and of a reconstituted nuclear non-hybrid male form also with hybrid origin.
  75. pmc Infectious bursal disease virus is an icosahedral polyploid dsRNA virus
    Daniel Luque
    Department of Structure of Macromolecules, Centro Nacional de Biotecnologia CSIC, Cantoblanco, 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 106:2148-52. 2009
    ..Our results show an unprecedented replicative strategy for dsRNA viruses and suggest that birnaviruses are living viral entities encompassing numerous functional and structural characteristics of positive and negative ssRNA viruses...
  76. pmc Alpha-gliadin genes from the A, B, and D genomes of wheat contain different sets of celiac disease epitopes
    Teun W J M van Herpen
    Allergy Consortium Wageningen, PO Box 16, NL 6700 AA Wageningen, The Netherlands
    BMC Genomics 7:1. 2006
    ..However, wheat gluten proteins cause celiac disease (CD) in 0.5 to 1% of the general population. Among these proteins, the alpha-gliadins contain several peptides that are associated to the disease...
  77. pmc Flow cytometric and microscopic analysis of the effect of tannic acid on plant nuclei and estimation of DNA content
    João Loureiro
    Laboratory of Biotechnology and Cytomics, Department of Biology, University of Aveiro, Campus Universitario de Santiago, 3810 193 Aveiro, Portugal
    Ann Bot 98:515-27. 2006
    ..In this study, the effect of tannic acid on estimation of nuclear DNA content was evaluated in Pisum sativum and Zea mays, which were chosen as model species...
  78. ncbi Her-2 oncogene amplification, chromosome 17 and DNA ploidy status in synovial sarcoma
    Zoltan Sapi
    Department of Pathology, St John s Hospital, Budapest, H 1125, Hungary
    Pathol Oncol Res 11:133-8. 2005
    ..Furthermore, this may open a theoretically new treatment possibility with Trastuzumab for Her-2-amplified cases of SS...
  79. ncbi DNA ploidy and its clinical implications in gastric cancer
    Hideo Baba
    Department of National Kyushu Cancer Center, Fukuoka, Japan
    Surgery 131:S63-70. 2002
    ..To precisely predict the biological behavior and clinical outcome of individual cancer, it may be important to clarify the DNA profiles of cancer cells in each case...
  80. ncbi Association of DNA pattern of metastatic lymph node with disease free survival in patients with intraoral squamous cell carcinoma
    Satya N Das
    Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India satya
    Indian J Med Res 122:216-23. 2005
    ..Therefore, the present study was undertaken to observe DNA pattern of primary tumours and their corresponding metastatic lymph nodes and its association with the clinicopathological parameters and prognosis...
  81. ncbi Modes of reproduction of the hybridogenetic fish Squalius alburnoides in the Tejo and Guadiana rivers: an approach with microsatellites
    María E Crespo-López
    Centro de Biologia Ambiental Departamento de Biologia Animal, Faculdade de Ciencias da Universidade de Lisboa, Bloco C2 3 piso, Campo Grande, 1749 016 Lisbon, Portugal
    Zoology (Jena) 109:277-86. 2006
    ..hispanica-like ancestor as the paternal ancestor of S. alburnoides...
  82. ncbi Nuclear DNA content, proliferative activity, and p53 expression related to clinical and histopathologic features in endometrial carcinoma
    Caroline Lundgren
    Department of Gynaecological Oncology, Radiumhemmet, Karolinska University Hospital, S 171 76 Stockholm, Sweden
    Int J Gynecol Cancer 12:110-8. 2002
    ..The combination of DNA ploidy, MIB-1, and p53 expression was an even stronger predictor of relapse-free survival than the individual prognostic factors...
  83. ncbi Endoreduplication and development: rule without dividing?
    J Traas
    Laboratoire de Biologie Cellulaire, INRA, Route de Saint Cyr, 78026 Versailles Cedex, France
    Curr Opin Plant Biol 1:498-503. 1998
    ..In Arabidopsis, the study of trichomes, leaf epidermis and hypocotyl cells sheds new light on the developmental regulation of this process, and its relation to cell expansion...
  84. ncbi A modified swim-up method reduces polyspermy during in vitro fertilization of porcine oocytes
    Chi Hun Park
    Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Science, Seoul National University, Seoul 151 921, Republic of Korea
    Anim Reprod Sci 115:169-81. 2009
    ..05). Our results demonstrated that the modified swim-up IVF method could reduce polyspermic penetration, and consequently produce better quality and karyotypically normal embryos in porcine IVF...
  85. ncbi An easier method to identify the individual genomic composition of allopolyploid complexes
    A Inacio
    Universidade de Lisboa, Faculdade de Ciencias de Lisboa, Centro de Biologia Ambiental Departamento de Biologia Animal, Bloco C2 3 degrees Piso, 1749 16, Campo Grande Lisboa, Portugal
    J Fish Biol 76:1995-2001. 2010
    ..The method is based on a length polymorphism detected in the beta-actin gene, which serves as the basis for the development of a semi-quantitative PCR...
  86. ncbi Unique hybrids between the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii
    Marjan Bovers
    CBS Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands
    FEMS Yeast Res 6:599-607. 2006
    ..Mating- and serotype-specific PCR reactions showed that the strains were MATa-serotype D/MATalpha-serotype B. This study is the first to describe naturally occurring hybrids between C. neoformans and C. gattii...
  87. ncbi Nuclear DNA endoreduplication and expression of the mitotic inhibitor Ccs52 associated to determinate and lupinoid nodule organogenesis
    Alfonso González-Sama
    Institut des Sciences du Vegetal, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2355, Avenue de la Terrasse, 91198 Gif sur Yvette, France
    Mol Plant Microbe Interact 19:173-80. 2006
    ..In view of our results, Ccs52A-mediated endoreduplication appears to be a universal mechanism required for nodule cell differentiation during the establishment of nitrogen-fixing symbioses...
  88. pmc Co-infection weakens selection against epistatic mutations in RNA viruses
    Remy Froissart
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520, USA
    Genetics 168:9-19. 2004
    ..We discuss our results in light of virus disease management and the evolutionary advantage of haploidy in biological populations...
  89. ncbi The influence of ploidy on the distribution of cells in chimaeric mouse blastocysts
    C A Everett
    Department of Obstetrics and Gynaecology, University of Edinburgh, UK
    Zygote 4:59-66. 1996
    ..This early effect may underlie the restricted distribution of tetraploid cells at later stages. We have demonstrated for the first time that ploidy can influence the relative position of blastomeres in the preimplantation embryo...
  90. ncbi Nuclear DNA content and pathology in radically treated pancreatic carcinoma. The prognostic significance of DNA ploidy, histology and nuclear grade
    M Rugge
    Cattedra di Istochimica and Immunoistochimica Patologica, Università di Padova ULSS 15 Veneto, Italy
    Cancer 77:459-66. 1996
    ..Histopathology and DNA ploidy were each correlated with survival in radically treated PC to ascertain the hierarchy of their prognostic significance...
  91. pmc Genetic and molecular analysis of the autosomal component of the primary sex determination signal of Drosophila melanogaster
    D A Barbash
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3204, USA
    Genetics 141:1451-71. 1995
    ....
  92. ncbi The interaction between daughterless and sex-lethal in triploids: a lethal sex-transforming maternal effect linking sex determination and dosage compensation in Drosophila melanogaster
    T W Cline
    Dev Biol 95:260-74. 1983
    ..The relationship of da+ and Sxl+ gene functions to those of other sex-specific lethal loci in D. melanogaster, and to sex determination mechanisms in other species, is discussed...
  93. ncbi DNA or cell kinetics flow cytometry analysis of 33 small gastrointestinal cancers treated by photodynamic therapy
    M T Foultier
    Faculte de Pharmacie, Nantes, France
    Cancer 73:1595-607. 1994
    ..However, there is a lack of prognostic criteria of efficacy as in other cancer treatment...
  94. ncbi Statistical model for characterizing epistatic control of triploid endosperm triggered by maternal and offspring QTLs
    Yuehua Cui
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Genet Res 86:65-75. 2005
    ..Also, the additive effect of the offspring QTLs is better estimated than the additive effect of the maternal QTLs. The implications of our model for agricultural and evolutionary genetic research are discussed...
  95. ncbi Ploidy changes associated with disruption of two adjacent genes on Leishmania major chromosome 1
    Santiago Martinez-Calvillo
    Seattle Biomedical Research Institute, 307 Westlake Ave N, Seattle, WA 98109 5219, USA
    Int J Parasitol 35:419-29. 2005
    ..Further evidence of genome plasticity in Leishmania was provided by changes in chr1 copy number that occurred during in vitro growth of wild-type LmjF promastigotes and following replacement of a single copy of LmjF01.0760...
  96. ncbi Entamoeba invadens: restriction of ploidy by colonic short chain fatty acids
    Jennifer Byers
    Department of Medical Parasitology, New York University School of Medicine, New York, NY 10010, USA
    Exp Parasitol 110:203-6. 2005
    ..Axenic growth of trophozoites in the absence of SCFAs, however, appears to allow trophozoites to increase the amount of DNA per cell, which they must do during the normal encystment process...
  97. ncbi Ploidy controls the success of mutators and nature of mutations during budding yeast evolution
    Dawn A Thompson
    Molecular and Cellular Biology Department, 16 Divinity Ave, Harvard University, Cambridge, MA 02138, USA
    Curr Biol 16:1581-90. 2006
    ..Mismatch repair defective and nonmutator strains were competed during adaptation to four laboratory environments (rich medium, low glucose, high salt, and a nonfermentable carbon source)...
  98. ncbi RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors
    Seetha V Srinivasan
    Department of Cell and Cancer Biology, Vontz Center for Molecular Studies, Ohio 45267, USA
    J Biol Chem 282:23867-77. 2007
    ..Collectively, these results demonstrate that deregulated S phase control is a key mechanism by which RB-deficient cells acquire elevated ploidy...
  99. ncbi Molecular evidence for an ancient duplication of the entire yeast genome
    K H Wolfe
    Department of Genetics, University of Dublin, Trinity College, Ireland
    Nature 387:708-13. 1997
    ..Tetraploidy may have facilitated the evolution of anaerobic fermentation in Saccharomyces...
  100. ncbi Patterns of reproductive isolation in three angiosperm genera
    Leonie C Moyle
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Evolution 58:1195-208. 2004
    ..In Silene, which included six polyploid species, results suggest that changes in ploidy disrupt a simple monotonic relationship between isolation and genetic distance...
  101. ncbi Three different origins for apparent triploid/diploid mosaics
    Art Daniel
    Departments of Cytogenetics, Western Sydney Genetics Program, The Children s Hospital at Westmead, P O Box 3515, Parramatta, NSW 2124, Australia
    Prenat Diagn 23:529-34. 2003
    ..This fetus developed normally and a normal infant was born with no evidence of triploidy in newborn blood or cord blood at three months of age...

Research Grants55

  1. Clinical Significance of Apoptosis in Colon Cancer
    Frank Sinicrope; Fiscal Year: 2006
    ..abstract_text> ..
  2. Aberrant Crypt Foci as a Biomarker for Chemoprevention
    Frank Sinicrope; Fiscal Year: 2009
    ....
  3. Mechanism of Meclp in the Checkpoint Response
    GEORGE BRUSH; Fiscal Year: 2006
    ..It is expected that these studies will provide significant insight into the molecular mechanisms underlying maintenance of the non-cancerous state under genotoxic conditions. ..
  4. Mechanistic Effects of Organic Selenium Against Colon C
    Mark Nelson; Fiscal Year: 2006
    ..abstract_text> ..
  5. Aneuploid Cells in the Human Placenta
    Heinz Ulrich Weier; Fiscal Year: 2006
    ..We will also have detailed information about the frequency, localization and types of aneuploid cells at the fetal-maternal interface and the effects of aneuploidy on CTB proliferation and HLA-G gene expression. ..
  6. BACKTRACKING TRANSLOCATIONS IN CHILDHOOD LEUKEMIA
    Joseph Wiemels; Fiscal Year: 2006
    ..We are ultimately working to elucidate the origin and causes of a cancer that might be preventable. [unreadable] [unreadable]..
  7. Cell cycle control by ORC1 and other E2F targets
    Maki Asano; Fiscal Year: 2005
    ..abstract_text> ..
  8. Yeast Assay for p53 Molecular Analysis in Bladder Cancer
    Ralph deVere White; Fiscal Year: 2005
    ..The results obtained during the period of this grant will form the basis for future studies that should affect treatment strategies for this disease. ..
  9. Molecular Diagnosis and Prognosis of Multiple Myeloma
    John Shaughnessy; Fiscal Year: 2004
    ..Thus, the work proposed supports the goals of an R33 project funded through PAR-01-106 (Applications of Innovative Technologies for the Molecular Analysis of Cancer). ..
  10. Regulation of polarized cell growth by GTPases
    Hay Oak Park; Fiscal Year: 2009
    ..abstract_text> ..
  11. Autosomal Mutagenesis and Polycystic Kidney Disease
    MITCHELL TURKER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. hAR Alterations and Androgen-Independent Prostate Cancer
    Ralph de Vere White; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  13. Prospective evaluation of IGF and IL-6 Dysregulation and Multiple Myeloma
    Graham A Colditz; Fiscal Year: 2010
    ..The team is led from by Drs. Colditz and Anderson and is supported by a senior statistician (Dr. Rosner) and a study director (Dr. Birmann) who is funded, in part, through a K award. ..
  14. CELL NON-AUTONOMOUS MODE OF TUMOR SUPPRESSION BY BRCA1
    Louis Dubeau; Fiscal Year: 2009
    ....
  15. Regulation of BRCA1 Function by Protein Phosphatase 1
    Lih Ching Hsu; Fiscal Year: 2009
    ..Lastly, we will also identify regulators of PP1 alpha activity toward BRCA1. ..
  16. BAC-FISH Assays for Sensitive Karyotyping of Cancer Cells
    Heinz Ulrich Weier; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. ROLE OF THE P34CDC2 RELATED PITSLRE PROTEIN KINASES
    Mark Nelson; Fiscal Year: 2007
    ..The greatest impact will be realized in the provision of novel molecular targets for therapeutic intervention strategies. ..
  18. Gene silencing in mammalian cells induced by environmental exposure
    MITCHELL TURKER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  19. Neuroblastoma Biology and Therapy
    GARRETT BRODEUR; Fiscal Year: 2007
    ..Furthermore, treatment strategies developed against neuroblastoma may be useful against other tumors in children and adults that are rely on the biological pathways and are affected by these agents. ..
  20. FUNCTIONS OF DIFFERENT P53 MUTATIONS IN PROSTATE CANCER
    Ralph deVere White; Fiscal Year: 2004
    ..The results obtained during the period of this grant proposal will form the basis for future studies that should affect treatment strategies for this disease. ..
  21. Signal Transduction Determining Fate of Stem Cells
    Naohiro Terada; Fiscal Year: 2003
    ..There will also be a poster session. The format of the Conference, and its small size, are designed to foster interactions among the 225 participants. ..
  22. BREAST CANCER AND FUNCTION IN AGING WOMEN
    Graham Colditz; Fiscal Year: 2001
    ....
  23. SPECTRUM OF MUTATION INDUCED BY IONIZING RADIATION
    MITCHELL TURKER; Fiscal Year: 2002
    ....
  24. RADIATION INDUCED THYROID CANCER
    Heinz Ulrich Weier; Fiscal Year: 2002
    ..We will prepare stable cell lines carrying the oncogenic rearrangements for further characterization and distribution. Finally, we will examine the levels and localization of mRNAs with Northern and in situ hybridization analysis. ..
  25. AUTOIMMUNE THROMBOCYTOPENIA
    Robert McMillan; Fiscal Year: 2002
    ..Results of these studies will be correlated with the patients' clinical course and thrombopoietin levels. In addition, the effect of immune thrombocytopenia on the patients' quality of life will be studied. ..
  26. Adnesion Receptors of the Insect Immune System
    JAMES NARDI; Fiscal Year: 2003
    ..Understanding the molecular underpinnings of the insect immune response will clearly help in understanding the fate of pathogens in the blood of insect vectors of human diseases. ..
  27. PROGENITORS FOR ERYTHROCYTIC & MEGAKARYOCYTIC LINEAGES
    WILLIAM SLAYTON; Fiscal Year: 2003
    ..Slayton's research progress. In this rich and supportive environment, Dr. Slayton will gain the experience necessary to contribute to the understanding of the early cellular and molecular events in megakaryopoiesis. ..
  28. Pluripotent Stem Cell using ES Cell Cytoplast
    Naohiro Terada; Fiscal Year: 2003
    ..In addition to such clinical significance, the current study could provide the basis for an improved system to explore the mechanisms underlying nuclear reprogramming. ..
  29. WOMEN'S REPRODUCTIVE HEALTH RESEARCH CAREER DEVELOPMENT
    W Hogge; Fiscal Year: 2003
    ..We believe that the organization, resources, enthusiastic young faculty and an exceptional group of senior faculty combined with resources of the WRHR Center provides an exceptional opportunity for the potential physician scientist. ..
  30. TELOMERASE ASSAY FOR OVARIAN CANCER DETECTION
    Louis Dubeau; Fiscal Year: 2004
    ..The potential influence of these agents on the sensitivity of testing for telomerase as a means of detecting ovarian cancer cells will be examined. ..
  31. ENDOTOXIN INDUCED MUCOUS CELL METAPLASIA
    Yohannes Tesfaigzi; Fiscal Year: 2003
    ..abstract_text> ..
  32. Flow Cytometry to Detect Human Tumor Cells in Body Fluid
    AWTAR GANJU KRISHAN; Fiscal Year: 2003
    ..3. Compare data collected from flow cytometric analysis with that obtained from cytopathology and immunocytochemistry routinely performed on these specimens for diagnostic purpose. ..
  33. NUTRIENTS EFFECT ON GENOTYPE IN BREAST CANCER
    Deborah Dillon; Fiscal Year: 2003
    ..abstract_text> ..
  34. RECOMBINATION MECHANISMS IN YEAST CELL DIFFERENTIATION
    James Haber; Fiscal Year: 2006
    ..abstract_text> ..
  35. SPATIAL CONTROL OF CELL POLARITY DURING YEAST BUDDING
    Hay Oak Park; Fiscal Year: 2003
    ..This work will also help us to understand the mechanism of genesis of human cancer since mutations in human homologs of these yeast proteins have been found in human tumor. ..
  36. The Rate and Molecular Spectrum of Spontaneous Mutations
    Michael Lynch; Fiscal Year: 2009
    ....
  37. PET IN MULTIMODALITY THERAPY FOR ESOPHAGEAL CANCER
    Edward Levine; Fiscal Year: 2002
    ..We plan to correlate the PET findings with endoscopic ultrasound (EUS), and spiral CT imaging to pathologic findings from resected specimens. ..
  38. Gene Silencing in Cancer--A Model System
    MITCHELL TURKER; Fiscal Year: 2003
    ..The demonstration of each step of a multistep silencing pathway, which is currently undefined, will provide novel insight into this aberrant process in malignant cells. ..
  39. CONFOCAL HISTOPATHOLOGY OF CONTACT DERMATITIS IN VIVO
    Salvador Gonzalez; Fiscal Year: 2002
    ..We also expect that our results may ultimately translate into more rational and effective care for patients with this common and frequently disabling problem. ..
  40. S. Cerevisiae Emergence of an Opportunistic Pathogen
    JOHN MCCUSKER; Fiscal Year: 2009
    ..cerevisiae population both phenotypically, for virulence and virulence-associated traits, and genotypically, for virulence-related genes. ..
  41. Myoglobin as an indicator of hpoxia tolerance
    STEPHEN KINSEY; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  42. Meningioma: Risk Factors and Quality of Life
    JOSEPH LEO WIEMELS; Fiscal Year: 2010
    ..This study represents the first concentrated effort to examine environmental and genetic risk factors for meningioma. ..
  43. Conference on Mammalian Gametogenesis & Embryogenesis
    Patricia Hunt; Fiscal Year: 2002
    ..A particularly important aspect of the Gordon Conference setting is the blending of young and established investigators to promote exchanges that will generate new ideas and foster new collaborations in the field. ..
  44. GENETIC DIVERSITY AND COMPLEX TRAITS IN S CEREVISIAE
    JOHN MCCUSKER; Fiscal Year: 2002
    ..the development of S. cerevisiae as genetically manipulable model for the pathogenic fungi and as a host for the interspecific reconstitution of fungal virulence. ..
  45. ANALYSIS OF GENETICALLY & ENVIRONMENTALLY OVERLAPPING YEAST QUANTITATIVE TRAITS
    John H McCusker; Fiscal Year: 2010
    ..Therefore, an improved understanding of quantitative traits will aid our understanding of how a harmless commensal/saprophytic yeast can become an opportunistic pathogen. ..
  46. GENETIC CONTROL OF MEIOTIC CHROMOSOME SEGREGATION
    Patricia Hunt; Fiscal Year: 2009
    ..The combined data from these studies will allow us to understand the control of recombination In mammals and how the events of prophase influence meiotic chromosome segregation. ..
  47. Mechanisms of In Vivo Cell Fusion
    Andrew Duncan; Fiscal Year: 2008
    ..Aim 2: To determine relevant properties of fusion-derived hepatocytes. Aim 3: To enhance in vivo cell fusion by expression of fusogenic viral envelope proteins. [unreadable] [unreadable] [unreadable]..
  48. PHASE VARIATION IN SACCHAROMYCES CEREVISIAE
    JOHN MCCUSKER; Fiscal Year: 2003
    ..The PHI genes will be introduced to the non-phase variable laboratory strain, 288c, in efforts to reconstruct phase variation. ..
  49. Fungal-specific drug targets: static vs. cidal starvation & toxic intermediates
    JOHN MCCUSKER; Fiscal Year: 2008
    ..The identification of fungicidal antifungal drugs, which is a long-term goal, will greatly improve human health. [unreadable] [unreadable] [unreadable]..
  50. CHROMOSOME COUNTING MECHANISMS IN SEX DETERMINIATION
    James Erickson; Fiscal Year: 2006
    ..Detailed understanding of the mechanics and circuitry underlying the process will prove even more instructive. ..
  51. Molecular Basis of Young Onset Colorectal Cancer
    Lisa Boardman; Fiscal Year: 2006
    ..Following achievement of these goals, I am confident that I will be ready to continue my career as a successful independent investigator committed to colerectal cancer prevention and control. ..
  52. The Mouse Oocyte: A New Assay for Reproductive Toxins
    Patricia Hunt; Fiscal Year: 2003
    ..In addition, because the observed meiotic disruption (congression failure) is an age-related defect in human oocytes, the data may provide important insight to human age-related aneuploidy. ..