r factors

Summary

Summary: A class of plasmids that transfer antibiotic resistance from one bacterium to another by conjugation.

Top Publications

  1. ncbi Plasmid R1--replication and its control
    Kurt Nordström
    Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, P O Box 596, S 751 24 Uppsala, Sweden
    Plasmid 55:1-26. 2006
  2. pmc Integron-containing IncU R plasmids pRAS1 and pAr-32 from the fish pathogen Aeromonas salmonicida
    Henning Sørum
    Department of Pharmacology, Microbiology, and Food Hygiene, Norwegian School of Veterinary Science, Oslo, Norway
    Antimicrob Agents Chemother 47:1285-90. 2003
  3. pmc Thirty-eight C-terminal amino acids of the coupling protein TraD of the F-like conjugative resistance plasmid R1 are required and sufficient to confer binding to the substrate selector protein TraM
    Andreas Beranek
    Institut für Molekulare Biowissenschaften, Karl Franzens Universitat Graz, Universitatsplatz 2, A 8010 Graz, Austria
    J Bacteriol 186:6999-7006. 2004
  4. pmc Transfer of multiple drug resistance plasmids between bacteria of diverse origins in natural microenvironments
    H Kruse
    Department of Pharmacology, Microbiology and Food Hygiene, Norwegian College of Veterinary Medicine, Oslo, Norway
    Appl Environ Microbiol 60:4015-21. 1994
  5. pmc Cooperativity between KorB and TrbA repressors of broad-host-range plasmid RK2
    M Zatyka
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Bacteriol 183:1022-31. 2001
  6. ncbi The relationship between aminoglycosides' RNA binding proclivity and their antiplasmid effect on an IncB plasmid
    Jason R Thomas
    Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, Illinois 61801, USA
    Biochemistry 44:6800-8. 2005
  7. ncbi Unsaturated fatty acids are inhibitors of bacterial conjugation
    Raul Fernandez-Lopez
    Departamento de Biología Molecular Unidad Asociada al CIB, CSIC, Universidad de Cantabria, C Herrera Oria s n, E 39011 Santander, Spain
    Microbiology 151:3517-26. 2005
  8. ncbi Combating drug-resistant bacteria: small molecule mimics of plasmid incompatibility as antiplasmid compounds
    Johna C B DeNap
    Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, IL 61801, USA
    J Am Chem Soc 126:15402-4. 2004
  9. ncbi Replication and partitioning of the broad-host-range plasmid RK2
    Katarzyna Kolatka
    Department of Molecular and Cellular Biology, Intercollegiate Faculty of Biotechnology, University of Gdansk, Kladki 24, Gdansk, Poland
    Plasmid 64:119-34. 2010
  10. pmc Transfer protein TraY of plasmid R1 stimulates TraI-catalyzed oriT cleavage in vivo
    W Karl
    , Biochemie und Mikrobiologie, , A-8010 Graz, Austria
    J Bacteriol 183:909-14. 2001

Research Grants

  1. Narp Expression and Drugs of Abuse
    Irving Reti; Fiscal Year: 2002
  2. CONJUGATIVE MOBILIZATION OF PLASMID R1162
    Richard Meyer; Fiscal Year: 2003
  3. Emotional Mechanisms /Blood-Injection-Injury Phobia
    Olubunmi Olatunji; Fiscal Year: 2004
  4. Antibiotic Susceptibility of Bacteria in Biofilms
    Philip Stewart; Fiscal Year: 2005
  5. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
  6. Global Mechanisms of Bacteriocin Resistance in Listeria
    Kurt Miller; Fiscal Year: 2007
  7. Development of Fluorescent Protein Biosensors
    S James Remington; Fiscal Year: 2008
  8. Environmental Bioinorganic Chemistry 2008 Gordon Research Conference
    Anne O Summers; Fiscal Year: 2008

Detail Information

Publications221 found, 100 shown here

  1. ncbi Plasmid R1--replication and its control
    Kurt Nordström
    Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, P O Box 596, S 751 24 Uppsala, Sweden
    Plasmid 55:1-26. 2006
    ..The clusters are plasmid-specific and presumably based on sequence homology...
  2. pmc Integron-containing IncU R plasmids pRAS1 and pAr-32 from the fish pathogen Aeromonas salmonicida
    Henning Sørum
    Department of Pharmacology, Microbiology, and Food Hygiene, Norwegian School of Veterinary Science, Oslo, Norway
    Antimicrob Agents Chemother 47:1285-90. 2003
    ....
  3. pmc Thirty-eight C-terminal amino acids of the coupling protein TraD of the F-like conjugative resistance plasmid R1 are required and sufficient to confer binding to the substrate selector protein TraM
    Andreas Beranek
    Institut für Molekulare Biowissenschaften, Karl Franzens Universitat Graz, Universitatsplatz 2, A 8010 Graz, Austria
    J Bacteriol 186:6999-7006. 2004
    ..Our results thus provide evidence that substrate selection within the IncF plasmid group is based on TraM's capability to select the correct DNA molecule for transport and not on substrate selection by the CP...
  4. pmc Transfer of multiple drug resistance plasmids between bacteria of diverse origins in natural microenvironments
    H Kruse
    Department of Pharmacology, Microbiology and Food Hygiene, Norwegian College of Veterinary Medicine, Oslo, Norway
    Appl Environ Microbiol 60:4015-21. 1994
    ....
  5. pmc Cooperativity between KorB and TrbA repressors of broad-host-range plasmid RK2
    M Zatyka
    School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom
    J Bacteriol 183:1022-31. 2001
    ....
  6. ncbi The relationship between aminoglycosides' RNA binding proclivity and their antiplasmid effect on an IncB plasmid
    Jason R Thomas
    Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, Illinois 61801, USA
    Biochemistry 44:6800-8. 2005
    ..These results highlight the potential for targeting key RNA regions for induction of plasmid loss and the subsequent resensitization of bacteria to antibiotics...
  7. ncbi Unsaturated fatty acids are inhibitors of bacterial conjugation
    Raul Fernandez-Lopez
    Departamento de Biología Molecular Unidad Asociada al CIB, CSIC, Universidad de Cantabria, C Herrera Oria s n, E 39011 Santander, Spain
    Microbiology 151:3517-26. 2005
    ..Two separate compounds were identified from these fractions: linoleic acid and dehydrocrepenynic acid. Downstream analysis showed that the chemical class of unsaturated fatty acids act as true inhibitors of conjugation...
  8. ncbi Combating drug-resistant bacteria: small molecule mimics of plasmid incompatibility as antiplasmid compounds
    Johna C B DeNap
    Department of Chemistry, Roger Adams Laboratory, University of Illinois, Urbana, IL 61801, USA
    J Am Chem Soc 126:15402-4. 2004
    ..The demonstration that a small molecule can mimic incompatibility, cause plasmid elimination, and resensitize bacteria to antibiotics opens up new targets for antibacterial research...
  9. ncbi Replication and partitioning of the broad-host-range plasmid RK2
    Katarzyna Kolatka
    Department of Molecular and Cellular Biology, Intercollegiate Faculty of Biotechnology, University of Gdansk, Kladki 24, Gdansk, Poland
    Plasmid 64:119-34. 2010
    ..This review will focus on two processes indispensable for plasmid DNA maintenance. We will summarize recent understanding of the molecular mechanisms contributing to the RK2 DNA replication and partitioning...
  10. pmc Transfer protein TraY of plasmid R1 stimulates TraI-catalyzed oriT cleavage in vivo
    W Karl
    , Biochemie und Mikrobiologie, , A-8010 Graz, Austria
    J Bacteriol 183:909-14. 2001
    ..These findings suggest that, whereas TraY and TraM function may overlap to a certain extent in the R1 relaxosome, TraM additionally performs a second function that is essential for successful conjugative transmission of plasmid DNA...
  11. pmc Plasmids spread very fast in heterogeneous bacterial communities
    Francisco Dionisio
    Faculté de Médicine Necker Enfants Malade, INSERM U571, Universite Paris V, 75730 Paris Cedex 15, France
    Genetics 162:1525-32. 2002
    ..This "amplification effect" could have an impact on the evolution of bacterial pathogens that exist in heterogeneous bacterial communities because conjugative plasmids can carry virulence or antibiotic-resistance genes...
  12. ncbi Escherichia coli R-factors unstable in Salmonella typhi are deleted before being segregated in this host
    Aurelio Mendoza-Medellín
    Departamento de Bioquimica, Facultad de Medicina, Universidad Autonoma del Estado de Mexico, Toluca, Estado de Mexico, Mexico
    Plasmid 51:75-86. 2004
    ..typhi but stable in Escherichia coli, suggesting that deletions imply loss of genetic information relevant for a plasmid stability mechanism operative in S. typhi, but not in E. coli...
  13. pmc The pcnB gene of Escherichia coli, which is required for ColE1 copy number maintenance, is dispensable
    M Masters
    Institute of Cell and Molecular Biology, University of Edinburgh, United Kingdom
    J Bacteriol 175:4405-13. 1993
    ..We confirm by immunological tests that PcnB is likely to be the commercially available enzyme poly(A) polymerase...
  14. ncbi Cloning and characterization of the chromosomal arsenic resistance genes from Acidithiobacillus caldus and enhanced arsenic resistance on conjugal transfer of ars genes located on transposon TnAtcArs
    Andre A Kotze
    Department of Microbiology, University of Stellenbosch, Private Bag X1, Matieland 7602, South Africa
    Microbiology 152:3551-60. 2006
    ..caldus ars genes of chromosomal origin. Plasmid pSa-mediated conjugal transfer of TnAtcArs from E. coli to At. caldus strains lacking the transposon was successful, and resulted in greatly increased levels of resistance to arsenite...
  15. pmc chpA and chpB, Escherichia coli chromosomal homologs of the pem locus responsible for stable maintenance of plasmid R100
    Y Masuda
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    J Bacteriol 175:6850-6. 1993
    ..These E. coli pem locus homologs may be involved in regulation of cell growth...
  16. ncbi Occurrence of chromium resistant thermotolerant coliforms in tannery effluent
    Tuhina Verma
    Department of Microbiology, Dr RML Avadh University, Faizabad, India
    Indian J Exp Biol 42:1112-6. 2004
    ..Among the nine strains, three were found predominantly uropathogenic Escherichia coli (UPEC) serotype 04, whereas two strains were untypable. In addition, 4 transconjugants also showed a positive result after serotyping...
  17. ncbi Sequence of the 50-kb conjugative multiresistance plasmid pRE25 from Enterococcus faecalis RE25
    F V Schwarz
    Laboratory for Food Microbiology, Swiss Federal Institute of Technology of Zurich, Zurich, CH 8092, Switzerland
    Plasmid 46:170-87. 2001
    ..It is concluded that pRE25 may contribute to the further spread of antibiotic-resistant microorganisms via food into the human community...
  18. ncbi The complete sequences of plasmids pB2 and pB3 provide evidence for a recent ancestor of the IncP-1beta group without any accessory genes
    H Heuer
    Department of Biological Sciences, University of Idaho, Moscow, ID 83844 3051, USA
    Microbiology 150:3591-9. 2004
    ..They must occasionally acquire accessory genes by transposition events, resulting in those plasmids that have been found based on selectable phenotypic traits...
  19. ncbi SHV-type extended-spectrum beta-lactamase (ESBL) are encoded in related plasmids from enterobacteria clinical isolates from Mexico
    Ulises Garza-Ramos
    Departamento de Resistencia Bacteriana, Centro de Investigaciones sobre Enfermedades Infecciosas, Instituto Nacional de Salud Publica, Mexico
    Salud Publica Mex 49:415-21. 2007
    ..In this work we report the molecular characterization of beta-lactam antibiotics resistance conferred by genes contained in plasmids from enterobacteria producing extended-spectrum beta-lactamases (ESBL)...
  20. ncbi Genetic basis of horizontal gene transfer among oral bacteria
    Adam P Roberts
    Division of Microbial Diseases, Eastman Dental Institute, University College London, University of London, London, UK
    Periodontol 2000 42:36-46. 2006
  21. ncbi Plasmid-mediated quinolone resistance in Australia
    José Manuel Rodríguez-Martínez
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, Universite Paris XI, K Bicêtre, France
    Microb Drug Resist 12:99-102. 2006
    ..However, the gene cassettes of the sul1-type integrons were different. This study identified the first plasmid-mediated quinolone resistance determinant in Enterobacteriaceae in Australia...
  22. ncbi Plasmid pB8 is closely related to the prototype IncP-1beta plasmid R751 but transfers poorly to Escherichia coli and carries a new transposon encoding a small multidrug resistance efflux protein
    Andreas Schluter
    Department of Biological Sciences, University of Idaho, Moscow, ID 83844 3051, USA
    Plasmid 54:135-48. 2005
    ..Although future work will have to determine the molecular basis for the poor transfer of pB8 to E. coli, our findings demonstrate that the host-range of typical IncP-1 plasmids may be less broad than expected...
  23. ncbi Antimicrobial resistance and plasmid profiles of urinary Escherichia coli isolates from Jordanian patients
    A A Shehabi
    Department of Pathology and Microbiology, Faculty of Medicine, University of Jordan, Amman, Jordan
    East Mediterr Health J 10:322-8. 2004
    ..coli isolates (67%) that were resistant to at least ampicillin, cotrimoxazole and tetracycline. This R-plasmid reservoir may contribute to the spread of multiple antibiotic resistance in our Region...
  24. ncbi Functional interactions between chpB and parD, two homologous conditional killer systems found in the Escherichia coli chromosome and in plasmid R1
    S Santos Sierra
    Centro de Investigaciones Biologicas CSIC, Madrid, Spain
    FEMS Microbiol Lett 168:51-8. 1998
    ....
  25. pmc Comparison of proteins involved in pilus synthesis and mating pair stabilization from the related plasmids F and R100-1: insights into the mechanism of conjugation
    K G Anthony
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
    J Bacteriol 181:5149-59. 1999
    ..Our results indicate that the specificity in recipient cell recognition and entry exclusion are mediated by TraN and TraG, respectively, and not by the pilus...
  26. ncbi Transcriptional organization of the temperature-sensitive transfer system from the IncHI1 plasmid R27
    Guillermina Alonso
    Instituto de Biologia Experimental, Facultad de Ciencias, Universidad Central de Venezuela Caracas, Venezuela
    Microbiology 151:3563-73. 2005
    ..These results should facilitate future understanding of the basis of temperature-sensitive transfer in this large conjugative plasmid...
  27. pmc In vivo transfer of high-level mupirocin resistance from Staphylococcus epidermidis to methicillin-resistant Staphylococcus aureus associated with failure of mupirocin prophylaxis
    Julian G Hurdle
    School of Biochemistry and Microbiology, University of Leeds, Leeds LS2 9JT, UK
    J Antimicrob Chemother 56:1166-8. 2005
    ..S. aureus and coagulase-negative staphylococci were isolated prior to, during and after 14 days of mupirocin treatment. The staphylococcal isolates and their plasmids were examined by molecular genetic methods...
  28. ncbi Molecular analysis of a mobilizable theta-mode trimethoprim resistance plasmid from coagulase-negative staphylococci
    S Apisiridej
    School of Biological Sciences, University of Sydney, Sydney, New South Wales, 2006, Australia
    Plasmid 38:13-24. 1997
    ..pSK639 is the first small plasmid of this type to be identified in the staphylococci...
  29. pmc F-like type IV secretion systems encode proteins with thioredoxin folds that are putative DsbC homologues
    Trevor C Elton
    Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
    J Bacteriol 187:8267-77. 2005
    ..TraF(F) is essential for conjugation but appears to have a function other than disulfide bond chemistry...
  30. ncbi The resistance and integrase genes of pACM1, a conjugative multiple-resistance plasmid, from Klebsiella oxytoca
    K E Preston
    Department of Pathology and Laboratory Medicine, Albany Medical College, New York 12208, USA
    Plasmid 37:105-18. 1997
    ..Integrase-mediated recombination might be responsible for genetic divergence in a widely distributed family of pACM1-like plasmids...
  31. ncbi Molecular characterization of Salmonella weltevreden isolated from poultry: evidence of conjugal transfer of plasmid and antibiotic resistance
    S Radu
    Department of Biotechnology, Faculty of Food Science and Biotechnology, University Putra Malaysia, Selangor
    Microbios 104:39-47. 2001
    ..These results suggest that poultry may constitute a reservoir for disseminating antibiotic resistance and that AP-PCR may be a valuable tool for epidemiological studies...
  32. ncbi Characterization of a novel type of MLSB resistance plasmid from Staphylococcus saprophyticus carrying a constitutively expressed erm(C) gene
    Tomasz Hauschild
    University of Bialystok, Institute of Biology, Department of Microbiology, 15 950 Bialystok, Swierkowa 20 B, Poland
    Vet Microbiol 115:258-63. 2006
    ..However, pSES22 was similar to several members of a diverse group of small plasmids, all of which carried closely related plasmid backbones consisting of the genes repU and pre/mob, but differed in their resistance genes...
  33. ncbi A simple phenotypic method for differentiation between acquired and chromosomal AmpC beta-lactamases in Escherichia coli
    Beatriz Mirelis
    Servicio de Microbiologia, Hospital de la Santa Creu i Sant Pau, Barcelona, Espana
    Enferm Infecc Microbiol Clin 24:370-2. 2006
    ..The purpose of this study was to assess screening methods for the detection of these enzymes in clinical isolates of Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis...
  34. ncbi Molecular analysis of oriT and MobA protein in the 7.4 kb mobilizable beta-lactamase plasmid pSJ7.4 from Neisseria gonorrhoeae
    Nydia M Rodriguez-Bonano
    School of Sciences, Mathematics and Technology, Universidad del Este, Carolina, Puerto Rico 00984
    Plasmid 52:89-101. 2004
    ..The carboxyl terminal region of MobA did not share homology with other mobilization proteins, but may be involved in promoting efficient transfer of pSJ7.4...
  35. ncbi Multilocus sequence typing of IncI1 plasmids carrying extended-spectrum beta-lactamases in Escherichia coli and Salmonella of human and animal origin
    Aurora García-Fernández
    Department of Infectious, Parasitic and Immune Mediated Diseases, Istituto Superiore di Sanita, Rome, Italy
    J Antimicrob Chemother 61:1229-33. 2008
    ..Plasmid multilocus sequence typing (pMLST) was developed to discern naturally occurring IncI1 plasmids in homogeneous groups according to their allele assortment...
  36. pmc Transferable, multiple antibiotic and mercury resistance in Atlantic Canadian isolates of Aeromonas salmonicida subsp. salmonicida is associated with carriage of an IncA/C plasmid similar to the Salmonella enterica plasmid pSN254
    Douglas McIntosh
    Research and Productivity Council, 921 College Hill Road, Fredericton, NB, Canada E3B 6Z9
    J Antimicrob Chemother 61:1221-8. 2008
    ..The aim of this study was to examine the molecular basis for multiple antibiotic and mercury resistance in Canadian isolates of Aeromonas salmonicida subsp. salmonicida...
  37. ncbi Effect of ecological factors on conjugal transfer of chromium-resistant plasmid in Escherichia coli isolated from tannery effluent
    Tuhina Verma
    Environmental Microbiology Division, Industrial Toxicology Research Centre, MG Marg, Lucknow, India
    Appl Biochem Biotechnol 102:5-20. 2002
    ..Curing of these strains resulted in loss of one or more resistance markers indicating the plasmid-borne resistance. Itis inferred that plasmid transferby conjugation occurs in wastewater bodies within a wide range of conditions...
  38. pmc Repressor gene finO in plasmids R100 and F: constitutive transfer of plasmid F is caused by insertion of IS3 into F finO
    Y Yoshioka
    J Bacteriol 169:619-23. 1987
    ....
  39. ncbi Nucleotide sequence of the structural genes for an anion pump. The plasmid-encoded arsenical resistance operon
    C M Chen
    J Biol Chem 261:15030-8. 1986
    ..A model is proposed in which these gene products form an anion translocating ATPase for extrusion of arsenite and arsenate from resistant cells...
  40. ncbi The 79,370-bp conjugative plasmid pB4 consists of an IncP-1beta backbone loaded with a chromate resistance transposon, the strA-strB streptomycin resistance gene pair, the oxacillinase gene bla(NPS-1), and a tripartite antibiotic efflux system of the resi
    A Tauch
    Zentrum für Genomforschung, Universitat Bielefeld, Universitatsstrasse 25, 33615, Bielefeld, Germany
    Mol Genet Genomics 268:570-84. 2003
    ..The global genetic organization of pB4 implies that its gene load might be disseminated between bacteria in different habitats by the combined action of the conjugation apparatus and the mobility of its component elements...
  41. pmc Characterization of insertion sequence IS946, an Iso-ISS1 element, isolated from the conjugative lactococcal plasmid pTR2030
    D A Romero
    Department of Microbiology, Southeast Dairy Foods Research Center, North Carolina State University, Raleigh 27695
    J Bacteriol 172:4151-60. 1990
    ..IS946 has perfect 18-bp terminal inverted repeats, identical to ISS1, and similarly generated 8-bp direct repeats of the target site upon insertion...
  42. ncbi A bacterial conjugation machinery recruited for pathogenesis
    Anja Seubert
    Division of Molecular Microbiology, Biozentrum of the University of Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Mol Microbiol 49:1253-66. 2003
    ....
  43. pmc NikAB- or NikB-dependent intracellular recombination between tandemly repeated oriT sequences of plasmid R64 in plasmid or single-stranded phage vectors
    Nobuhisa Furuya
    Department of Biology, Tokyo Metropolitan University, Minamiohsawa, Hachioji, Tokyo 192 0397, Japan
    J Bacteriol 185:3871-7. 2003
    ..coli cells, whereas such a reaction in double-stranded oriT DNA requires collaboration of the two relaxosome proteins, NikA and NikB...
  44. ncbi Impact of antibiotics on conjugational resistance gene transfer in Staphylococcus aureus in sewage
    Knut Ohlsen
    Institute for Molecular Biology of Infectious Diseases, The University of Würzburg, Rontgenring 11, D 97070 Wurzburg, Germany
    Environ Microbiol 5:711-6. 2003
    ..1x10(-5)-5.0x10(-8). However, low-level concentrations of antibiotics measured in sewage are below concentrations that can increase plasmid transfer frequencies of gentamicin resistance plasmids of staphylococci...
  45. ncbi Occurrence of plasmid-mediated ampicillin resistance among enterobacteria from the ovine rumen
    R Malik
    Institute of Animal Physiology, Slovak Academy of Sciences, 040 01 Kosice, Slovakia
    Folia Microbiol (Praha) 49:187-90. 2004
    ..The small tem1 carrying plasmid and its transfer (mobilization) was detected and partially characterized after conjugation to laboratory Escherichia coli strain...
  46. ncbi Complete nucleotide sequence and gene organization of the broad-host-range plasmid RSF1010
    P Scholz
    Max Planck Institute for Molecular Genetics, Berlin, F R G
    Gene 75:271-88. 1989
    ..The sequencing results are discussed in relation to the systems of replication, host range, conjugal mobilization and antibiotic resistance determinants associated with the RSF1010 plasmid...
  47. ncbi Mercury volatilization by R factor systems in Escherichia coli isolated from aquatic environments of India
    Neerja Gupta
    Gene Expression Laboratory, Department of Biosciences, Jamia Millia Islamia, New Delhi 110025, India
    Curr Microbiol 48:88-96. 2004
    ..MRD14 volatilized mercury most efficiently...
  48. pmc A subassembly of R27-encoded transfer proteins is dependent on TrhC nucleoside triphosphate-binding motifs for function but not formation
    Matthew W Gilmour
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2R3, Canada
    J Bacteriol 186:1606-13. 2004
    ..These results indicate that TrhC requires intact NTP-binding motifs to function during conjugative transfer but that these motifs are not essential for the assembly of TrhC into a complex with other transfer proteins...
  49. ncbi Cloning of the gene conferring resistance to mupirocin in Staphylococcus aureus
    K G Dyke
    Department of Biochemistry, University of Oxford, U K
    FEMS Microbiol Lett 61:195-8. 1991
    ..The amino acid sequence is identical for eight amino acids with the sequence of isoleucyl tRNA synthetase of E. coli. This finding adds to the evidence that mupirocin resistance is the result of a modified isoleucyl tRNA synthetase...
  50. ncbi Multidrug-resistant Pseudomonas aeruginosa strains harbouring R-plasmids and AmpC beta-lactamases isolated from hospitalised burn patients in a tertiary care hospital of North India
    M Shahid
    Department of Microbiology, JN Medical College Hospital, Aligarh Muslim University, Aligarh 202002, India
    FEMS Microbiol Lett 228:181-6. 2003
    ..This is among the first reports regarding the emergence of plasmid-mediated resistance to amikacin and the occurrence of AmpC beta-lactamases in P. aeruginosa strains from India...
  51. ncbi Nucleotide sequence of pOLA52: a conjugative IncX1 plasmid from Escherichia coli which enables biofilm formation and multidrug efflux
    Anders Norman
    Department of Biology, Evolution and Microbiology Section, University of Copenhagen, Sølvgade 83H, DK 1307 Copenhagen K, Denmark
    Plasmid 60:59-74. 2008
    ....
  52. ncbi Characterization of Escherichia coli isolates incriminated in colisepticaemia in mink
    R J Tibbetts
    Department of Veterinary Pathology, Purdue University School of Veterinary Medicine, 1175 Animal Disease Diagnostic Laboratory, West Lafayette, IN 47907, USA
    Vet Res Commun 27:341-57. 2003
    ..The results show that the E. coli isolates implicated in mink colisepticaemia possess similar virulence traits and antimicrobial resistance phenotypes to those associated with diarrhoeal diseases in food animals...
  53. ncbi Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus
    Linda M Weigel
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 302:1569-71. 2003
    ..Genetic analyses suggest that the long-anticipated transfer of vancomycin resistance to a methicillin-resistant S. aureus occurred in vivo by interspecies transfer of Tn1546 from a co-isolate of Enterococcus faecalis...
  54. pmc Origin of transfer of IncF plasmids and nucleotide sequences of the type II oriT, traM, and traY alleles from ColB4-K98 and the type IV traY allele from R100-1
    B B Finlay
    J Bacteriol 168:132-9. 1986
    ..The translational start codons of the ColB4 and R100-1 traY genes are GUG and UUG, respectively, two examples of rare initiator codon usage...
  55. pmc Sequence of conjugative plasmid pIP1206 mediating resistance to aminoglycosides by 16S rRNA methylation and to hydrophilic fluoroquinolones by efflux
    Bruno Perichon
    Unite des Agents Antibacteriens, Institut Pasteur, Paris, France
    Antimicrob Agents Chemother 52:2581-92. 2008
    ....
  56. pmc R391: a conjugative integrating mosaic comprised of phage, plasmid, and transposon elements
    Dietmar Böltner
    Department of Biological Sciences, University of Essex, Colchester, United Kingdom
    J Bacteriol 184:5158-69. 2002
    ..Challenging the previous assumption that IncJ elements are plasmids, no plasmid replicon was identified on R391, suggesting that they cannot replicate autonomously...
  57. ncbi Detailed analysis of the insertion site of the mobile elements R997, pMERPH, R392, R705 and R391 in E. coli K12
    Barry M McGrath
    Biochemistry Laboratory, Department of Chemical and Environmental Sciences, University of Limerick, Limerick, Ireland
    FEMS Microbiol Lett 237:19-26. 2004
    ..The attB site is highly conserved and found in many different bacteria, suggesting a possible broad host range...
  58. pmc Mutations conferring resistance to azide in Escherichia coli occur primarily in the secA gene
    Y Fortin
    Department of Microbiology and Immunology, Universite de Montreal, Quebec, Canada
    J Bacteriol 172:6607-10. 1990
    ..That azide inhibits SecA is consistent with the fact that SecA has ATPase activity, an activity that is often prone to inhibition by azide...
  59. ncbi Microbiology. Triple-threat microbe gained powers from another bug
    Dan Ferber
    Science 302:1488. 2003
  60. pmc Structure of beta-crystallite assemblies formed by Alzheimer beta-amyloid protein analogues: analysis by x-ray diffraction
    H Inouye
    Children s Hospital, Boston, Massachusetts 02115
    Biophys J 64:502-19. 1993
    ..Thus, our analysis of the fiber x-ray patterns from beta/A4 peptides shows the organization of the beta-crystallites that form the wall of the amyloid fibrils as well as possible side-chain interactions...
  61. ncbi Refined crystal structures of guanine nucleotide complexes of adenylosuccinate synthetase from Escherichia coli
    B W Poland
    Department of Biochemistry and Biophysics, Iowa State University, Ames, Iowa 50011, USA
    J Biol Chem 271:15407-13. 1996
    ....
  62. ncbi Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo
    C A McPhalen
    Department of Biochemistry, University of Alberta, Edmonton, Canada
    Biochemistry 27:6582-98. 1988
    ..The structures have been fully refined by restrained-parameter least-squares methods to crystallographic R factors (sigma[[Fo[ - [Fc[[/sigma[Fo[) of 0.136 at 1.8-A resolution and 0.154 at 2.1-A resolution, respectively...
  63. ncbi Refined crystal structures of unligated adenylosuccinate synthetase from Escherichia coli
    M M Silva
    Dept of Biochemistry and Biophysics, Iowa State University, Ames 50011, USA
    J Mol Biol 254:431-46. 1995
    ..The structural elements of the p21 ras and G alpha proteins responsible for binding Mg2+ are either absent from the synthetase or unavailable for the coordination of metal cations...
  64. ncbi Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity
    V S Stoll
    Department of Biochemistry, University of Toronto, Ontario Cancer Institute, Canada
    Biochemistry 36:6437-47. 1997
    ..The corresponding molecular structures have been characterized at resolutions between 2.3 and 2.8 A with R factors ranging from 17.1 to 19.7%...
  65. ncbi Mechanism of the Schiff base forming fructose-1,6-bisphosphate aldolase: structural analysis of reaction intermediates
    Esben Lorentzen
    European Molecular Biology Laboratory, Hamburg Outstation, Germany
    Biochemistry 44:4222-9. 2005
    ..The structures, determined at a resolution of 1.9 A and refined to crystallographic R factors of 0.148 and 0...
  66. ncbi Probing the catalytic mechanism of GDP-4-keto-6-deoxy-d-mannose Epimerase/Reductase by kinetic and crystallographic characterization of site-specific mutants
    C Rosano
    Department of Physics INFM and Advanced Biotechnology Center IST, University of Genova, Largo Rosanna Benzi 10, Genova, I 16132, Italy
    J Mol Biol 303:77-91. 2000
    ..Finally, the additional role of mutated active-site residues involved in substrate recognition and in enzyme stability has been analyzed...
  67. ncbi Structure of a pseudomerohedrally twinned monoclinic crystal form of a pyridoxal phosphate-dependent catalytic antibody
    Béatrice Golinelli-Pimpaneau
    Laboratoire d Enzymologie et de Biochimie Structurales, Batiment 34, CNRS, 1 Avenue de la Terrasse, 91190 Gif sur Yvette, France
    Acta Crystallogr D Biol Crystallogr 61:472-6. 2005
    ..7, c = 79.3 A and beta is fortuitously 90 degrees . Refinement of the structure converged at unacceptably high R factors. Although the traditional analysis of intensity distribution did not indicate twinning, pseudomerohedral ..
  68. ncbi Structures of Escherichia coli histidinol-phosphate aminotransferase and its complexes with histidinol-phosphate and N-(5'-phosphopyridoxyl)-L-glutamate: double substrate recognition of the enzyme
    K Haruyama
    Department of Chemistry, Graduate School of Science, Osaka City University, Sugimoto, Sumiyoshi ku, Osaka 558 8585, Japan
    Biochemistry 40:4633-44. 2001
    ....
  69. pmc Structural basis for the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism
    L S Beese
    Department of Molecular Biophysics, Yale University, New Haven, CT 06511
    EMBO J 10:25-33. 1991
    ..9 A from the first. Virtually all aspects of the pretransition state substrate complex are directly seen in the structures, and only very small changes in the positions of phosphate atoms are required to form the transition state...
  70. ncbi Structures and comparison of the Y98H (2.0 A) and Y98W (1.5 A) mutants of flavodoxin (Desulfovibrio vulgaris)
    R A Reynolds
    Physics Department, Grand Valley State University, Allendale, Michigan, USA
    Acta Crystallogr D Biol Crystallogr 57:527-35. 2001
    ..Final R factors of 17% for the Y98H mutant and 9.8% for the Y98W mutant were obtained. For the high-resolution (1...
  71. ncbi Structure of tyrosyl-tRNA synthetase refined at 2.3 A resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate
    P Brick
    Blackett Laboratory, Imperial College, London, England
    J Mol Biol 208:83-98. 1989
    ..The adenine moiety appears to make no significant polar interactions with the protein. The results of site-directed mutagenesis studies are examined in the light of these refined structures...
  72. ncbi X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis
    A Lavie
    Department of Biochemistry, Brandeis University, Massachusetts 02254 9110
    Biochemistry 33:5469-80. 1994
    ..Calculations of the solvent-accessible surface of possible dimers, with and without the alpha-helical C-terminal domain, suggest that the tetramer is the active form of this xylose isomerase...
  73. ncbi Risk factors associated with extended-spectrum beta-lactamase-producing organisms at a tertiary care hospital
    Eileen M Graffunder
    Department of Epidemiology MC 45, Albany Medical Center, NY 12208, USA
    J Antimicrob Chemother 56:139-45. 2005
    ..This study investigated the relationship between antibiotic usage and ESBL organisms from 1994 through 2002 using epidemiological and molecular analysis...
  74. ncbi The crystal structure of a family 5 endoglucanase mutant in complexed and uncomplexed forms reveals an induced fit activation mechanism
    R Dominguez
    Unité d Immunologie Structurale, Institut Pasteur, Paris, France
    J Mol Biol 257:1042-51. 1996
    ....
  75. pmc Activator anion binding site in pyridoxal phosphorylase b: the binding of phosphite, phosphate, and fluorophosphate in the crystal
    N G Oikonomakos
    Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, Athens, Greece
    Protein Sci 5:2416-28. 1996
    ..native-like unit cell dimensions, and the structures of the complexes have been refined to give crystallographic R factors of 18.5-19.2%, for data between 8 and 2.4 A resolution...
  76. pmc Crystal structures of medium-chain acyl-CoA dehydrogenase from pig liver mitochondria with and without substrate
    J J Kim
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee 53226
    Proc Natl Acad Sci U S A 90:7523-7. 1993
    ..4-A resolution to R factors of 0.172 and 0.173, respectively...
  77. ncbi Children with congenital hypothyroidism and their siblings: do they really differ?
    Joanne F Rovet
    Department of Pediatrics, Brain and Behavior Program, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Pediatrics 115:e52-7. 2005
    ..The purpose of this study was to compare the results of children with CH and their unaffected siblings at the same age and with the same test...
  78. ncbi The solution structure of motilin from NMR distance constraints, distance geometry, molecular dynamics, and an iterative full relaxation matrix refinement
    S Edmondson
    Department of Medical Biochemistry, School of Medicine, Southern Illinois University, Carbondale 62901
    Biochemistry 30:11271-9. 1991
    ..18 for the region from Glu9 to Lys20, and 0.29 for the region from Phe1 to Gly8. R factors for the same regions were 0.27, 0.19, and 0.43, respectively...
  79. ncbi Refined X-ray structures of the oxidized, at 1.3 A, and reduced, at 1.17 A, [2Fe-2S] ferredoxin from the cyanobacterium Anabaena PCC7119 show redox-linked conformational changes
    R Morales
    Laboratoire de Cristallographie et de Cristallogenese des Proteines, Laboratoire d Enzymologie Moleculaire, and Laboratoire de Spectrométrie de Masse, Institut de Biologie Structurale J P Ebel, CEA CNRS, 41 rue Jules Horowitz, France
    Biochemistry 38:15764-73. 1999
    ..Superposition of the three crystallographically independent molecules shows that the putative recognition site with the physiological partner (FNR) involves charged, hydrophobic residues and invariant water molecules...
  80. ncbi Role of the divalent metal ion in sugar binding, ring opening, and isomerization by D-xylose isomerase: replacement of a catalytic metal by an amino acid
    K N Allen
    Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts 02254 9110
    Biochemistry 33:1488-94. 1994
    ..8-A resolution and refined to R factors of 17.7% and 19.7%, respectively...
  81. ncbi Structure refinement of fructose-1,6-bisphosphatase and its fructose 2,6-bisphosphate complex at 2.8 A resolution
    H M Ke
    Gibbs Chemical Laboratory, Harvard University, Cambridge, MA 02138
    J Mol Biol 212:513-39. 1990
    ..The structures are described in detail including interactions of interchain surfaces, and the chemically modifiable residues are discussed on the basis of the refined structures.(ABSTRACT TRUNCATED AT 400 WORDS)..
  82. ncbi Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications
    V M Reyes
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093 0317
    Biochemistry 34:2710-23. 1995
    ..1 and 0.6 A, respectively, and are equidistant from alpha B and alpha C.(ABSTRACT TRUNCATED AT 400 WORDS)..
  83. ncbi Crystal structure reveals two alternative conformations in the active site of ribonuclease Sa2
    Jozef Sevcik
    Institute of Molecular Biology, Member of the Centre of Excellence for Molecular Medicine, Slovak Academy of Sciences, Dubravska cesta 21, 84551 Bratislava, Slovak Republic
    Acta Crystallogr D Biol Crystallogr 60:1198-204. 2004
    ..were determined by molecular replacement using the coordinates of RNase Sa as a search model and were refined to R factors of 17.5 and 15.0% and R(free) factors of 21.8 and 17.2%, respectively...
  84. pmc Two crystal structures for cathepsin D: the lysosomal targeting signal and active site
    P Metcalf
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 12:1293-302. 1993
    ..For bovine cathepsin D the corresponding figures are 0.014 A and 3.3 degrees. The crystallographic residuals (R factors) are 16.1% and 15.8% for the human and inhibited bovine cathepsin D models respectively...
  85. ncbi Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate
    D C Hyatt
    Department of Biochemistry, University of Arizona, Tucson 85721, USA
    Biochemistry 36:4585-94. 1997
    ..6 and 2.2 A nominal resolutions, with crystallographic R factors of 0.180 and 0.178, respectively...
  86. ncbi Structure and function of a regulated archaeal triosephosphate isomerase adapted to high temperature
    Helen Walden
    Centre for Biomolecular Sciences, University of St Andrews, St Andrews, Fife KY16 9ST, Scotland, UK
    J Mol Biol 342:861-75. 2004
    ..The comparison confirms the increase in charged surface-exposed residues at the expense of polar residues...
  87. ncbi Influences of parenting on normal personality traits
    Irving M Reti
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, 600 N Wolfe St, Meyer 3 181, Baltimore, MD 21205, USA
    Psychiatry Res 111:55-64. 2002
    ..but moderately, correlate with measures of normal personality, the strongest associations being with the NEO-PI-R factors, neuroticism and conscientiousness, and with the TCI factors, self-directedness and harm avoidance...
  88. ncbi Molecular complementarity between tetracycline and the GTPase active site of elongation factor Tu
    Susan E Heffron
    Department of Physiology and Biophysics, 346 D Med Sci I, University of California, Irvine, CA 92697 4560, USA
    Acta Crystallogr D Biol Crystallogr 62:1392-400. 2006
    ..Atomic coordinates have been refined to crystallographic R factors of 18.0% for the P2(1) form and 20.0% for the P4(3)2(1)2 form...
  89. ncbi Modification of clay barriers with a cationic surfactant to improve the retention of pesticides in soils
    M S Rodriguez-Cruz
    Instituto de Recursos Naturales y Agrobiologia de Salamanca, CSIC, Salamanca, Spain
    J Hazard Mater 139:363-72. 2007
    ..78). Significant correlations were also found between these R factors and the pore volume values corresponding to the maximum peaks of the BTCs (r2=0.83; p<0...
  90. ncbi Structures of two lectins from the roots of pokeweed (Phytolacca americana)
    Tomomi Fujii
    Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
    Acta Crystallogr D Biol Crystallogr 60:665-73. 2004
    ..65 and 1.5 A resolution with R factors of 17.2 and 17.6%, respectively...
  91. ncbi Crystal structure of pyridoxamine-pyruvate aminotransferase from Mesorhizobium loti MAFF303099
    Yu Yoshikane
    Department of Bioresources Science, Faculty of Agriculture, Kochi University, Monobe Otsu 200, Nankoku, Kochi 783 8502, Japan
    J Biol Chem 283:1120-7. 2008
    ..the structures of PPAT in complexes with pyridoxamine, pyridoxal, and pyridoxyl-L-alanine have been refined to R factors of 15.6, 15.4, and 14.5% (R(free) = 18.6, 18.1, and 18.4%) at 1.7, 1.7, and 2.0 A resolution, respectively...
  92. ncbi The structure of bacteriorhodopsin at 3.0 A resolution based on electron crystallography: implication of the charge distribution
    K Mitsuoka
    Department of Biophysics Faculty of Science, Kyoto University, Oiwake cho Kitashirakawa, Sakyo ku, Kyoto, 606 8502, Japan
    J Mol Biol 286:861-82. 1999
    ..In addition, peaks found around the acidic residues Glu74, Glu194 and Glu212 have different features and might represent positive charges on polarised water molecules or hydroxonium ions...
  93. ncbi Mechanism of phosphate transfer by nucleoside diphosphate kinase: X-ray structures of the phosphohistidine intermediate of the enzymes from Drosophila and Dictyostelium
    S Morera
    Laboratoire de Biologie Structurale, UMR 9920 CNRS Université Paris Sud, Gif sur Yvette, France
    Biochemistry 34:11062-70. 1995
    ..1 and 2.2 A resolution, respectively. The atomic models, refined to R factors below 20%, show no conformation change relative to the free proteins...
  94. ncbi Inhibition of class A and class C beta-lactamases by penems: crystallographic structures of a novel 1,4-thiazepine intermediate
    Michiyoshi Nukaga
    Department of Molecular and Cell Biology, The University of Connecticut, Storrs, Connecticut 06269 3125, USA
    Biochemistry 42:13152-9. 2003
    ..In the class C complex, a water molecule on the beta-face is disordered and poorly activated for hydrolysis. Here, the acyl intermediate is unable to assist its own hydrolysis, as is thought to occur with many class C substrates...
  95. ncbi Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase
    Y Zhang
    Gibbs Chemical Laboratory, Harvard University, Cambridge, Massachusetts 02138
    Biochemistry 32:1844-57. 1993
    ..Structures have been refined at resolutions of 2.5 to 3.0 A to R factors of 0.172 to 0.195 with root-mean-square deviations of 0.012-0.018 A and 2.7-3...
  96. ncbi Crystal structures of aconitase with trans-aconitate and nitrocitrate bound
    H Lauble
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee 53226
    J Mol Biol 237:437-51. 1994
    ....
  97. ncbi NMR structure determination of a novel conotoxin, [Pro 7,13] alpha A-conotoxin PIVA
    K H Han
    Biomolecular Structure Research Unit, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
    Biochemistry 36:1669-77. 1997
    ..5 a...
  98. ncbi Binding of the antitumor drug nogalamycin and its derivatives to DNA: structural comparison
    Y G Gao
    Department of Physiology and Biophysics, University of Illinois, Urbana 61801
    Biochemistry 29:10307-16. 1990
    ..Both structures (in space group P6(1)) have been refined with constrained refinement procedure to final R factors of 0.208 (3386 reflections) and 0.196 (2143 reflections)...
  99. ncbi Atomic resolution structures of oxidized [4Fe-4S] ferredoxin from Bacillus thermoproteolyticus in two crystal forms: systematic distortion of [4Fe-4S] cluster in the protein
    Keiichi Fukuyama
    Department of Biology Graduate School of Science, Osaka University, 1 1 Machikaneyama, Toyonaka, Osaka, 560 0043, Japan
    J Mol Biol 315:1155-66. 2002
    ..The compressed direction of the cluster relative to the protein is conserved in the two crystal forms and consistent with that in one of the clusters in Clostridium acidurici ferredoxin...
  100. ncbi Structure and dynamics of the antitumor drugs nogalamycin and disnogalamycin complexed to d(CGTACG)2: comparison of crystal and solution structures
    H Robinson
    Biophysics Division, University of Illinois at Urbana Champaign, 61801
    Gene 149:179-88. 1994
    ..Specific hydrogen bonds between the drug and G:C bases in both grooves of the helix are preserved in the solution structure. A separate study of the 2:1 complex at low pH showed that the terminal G-C base pairing is destabilized...
  101. pmc Statistical coupling analysis of aspartic proteinases based on crystal structures of the Trichoderma reesei enzyme and its complex with pepstatin A
    Alessandro S Nascimento
    Grupo de Cristalografia, Departamento de Fisica e Informatica, Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, Av Trabalhador Saocarlense, 400, CEP 13560 970, Sao Carlos, Sao Paulo, Brazil
    J Mol Biol 382:763-78. 2008
    ....

Research Grants9

  1. Narp Expression and Drugs of Abuse
    Irving Reti; Fiscal Year: 2002
    ..B) Develop methods to manipulate expression of Narp in the VTA using the herpes simplex virus vector system. ..
  2. CONJUGATIVE MOBILIZATION OF PLASMID R1162
    Richard Meyer; Fiscal Year: 2003
    ..How pSCl0l has become independent of these proteins will investigated. Overall, these studies will provide insight into how the relaxosome directs plasmid DNA to the conjugal pore for transfer. ..
  3. Emotional Mechanisms /Blood-Injection-Injury Phobia
    Olubunmi Olatunji; Fiscal Year: 2004
    ..This research will provide an important contribution to the understanding of the emotions that mediate BII phobia, thus potentially providing a foundation for incorporating effective treatment strategies. ..
  4. Antibiotic Susceptibility of Bacteria in Biofilms
    Philip Stewart; Fiscal Year: 2005
    ..This project will afford a rich interdisciplinary training experience for the three participating graduate students. ..
  5. Plasmid-Mediated Quinolone Resistance
    George Jacoby; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  6. Global Mechanisms of Bacteriocin Resistance in Listeria
    Kurt Miller; Fiscal Year: 2007
    ..The research ultimately will lead to better methods for prevention of food contamination and disease caused by the deadly pathogen, Listeria monocytogenes. [unreadable] [unreadable] [unreadable]..
  7. Development of Fluorescent Protein Biosensors
    S James Remington; Fiscal Year: 2008
    ..abstract_text> ..
  8. Environmental Bioinorganic Chemistry 2008 Gordon Research Conference
    Anne O Summers; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..