tumor suppressor genes

Summary

Summary: Genes that inhibit expression of the tumorigenic phenotype. They are normally involved in holding cellular growth in check. When tumor suppressor genes are inactivated or lost, a barrier to normal proliferation is removed and unregulated growth is possible.

Top Publications

  1. ncbi The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    Arnold J Levine
    Institute for Advanced Study, Princeton, NJ 08540, USA
    Science 330:1340-4. 2010
  2. pmc A microRNA expression signature of human solid tumors defines cancer gene targets
    Stefano Volinia
    Department of Molecular Virology, Immunology, and Medical Genetics and Cancer Comprehensive Center, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:2257-61. 2006
  3. ncbi Cancer cell cycles
    C J Sherr
    Howard Hughes Medical Institute, Department of Tumor Cell Biology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Science 274:1672-7. 1996
  4. ncbi A gene hypermethylation profile of human cancer
    M Esteller
    The Johns Hopkins Comprehensive Cancer Center, 1650 Orleans Street, Baltimore, MD 21231, USA
    Cancer Res 61:3225-9. 2001
  5. ncbi DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
    Ina Rhee
    The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 416:552-6. 2002
  6. ncbi The history of cancer epigenetics
    Andrew P Feinberg
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Rev Cancer 4:143-53. 2004
  7. pmc Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma
    Bin Yang
    Department of Pathology, The Johns Hopkins Medical Institutions, Pathology Building Room 406, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Am J Pathol 163:1101-7. 2003
  8. ncbi A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
    Y Miki
    Department of Medical Informatics, University of Utah Medical Center, Salt Lake City 84132
    Science 266:66-71. 1994
  9. ncbi KiSS-1, a novel human malignant melanoma metastasis-suppressor gene
    J H Lee
    Department of Experimental Pathology, Jake Gittlen Cancer Research Institute, College of Medicine, Pennsylvania State University, Hershey 17033 0850, USA
    J Natl Cancer Inst 88:1731-7. 1996
  10. ncbi Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase
    T Xu
    Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Development 121:1053-63. 1995

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Detail Information

Publications316 found, 100 shown here

  1. ncbi The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    Arnold J Levine
    Institute for Advanced Study, Princeton, NJ 08540, USA
    Science 330:1340-4. 2010
    ..on producing intermediates for cell growth and division, and it is regulated by both oncogenes and tumor suppressor genes in a number of key cancer-producing pathways...
  2. pmc A microRNA expression signature of human solid tumors defines cancer gene targets
    Stefano Volinia
    Department of Molecular Virology, Immunology, and Medical Genetics and Cancer Comprehensive Center, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 103:2257-61. 2006
    ..Our results indicate that miRNAs are extensively involved in cancer pathogenesis of solid tumors and support their function as either dominant or recessive cancer genes...
  3. ncbi Cancer cell cycles
    C J Sherr
    Howard Hughes Medical Institute, Department of Tumor Cell Biology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38105, USA
    Science 274:1672-7. 1996
    ..Like the tumor suppressor protein p53, components of this "RB pathway," although not essential for the cell cycle per se, may participate in checkpoint functions that regulate homeostatic tissue renewal throughout life...
  4. ncbi A gene hypermethylation profile of human cancer
    M Esteller
    The Johns Hopkins Comprehensive Cancer Center, 1650 Orleans Street, Baltimore, MD 21231, USA
    Cancer Res 61:3225-9. 2001
    ....
  5. ncbi DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
    Ina Rhee
    The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA
    Nature 416:552-6. 2002
    ..Here we demonstrate that two enzymes cooperatively maintain DNA methylation and gene silencing in human cancer cells, and provide compelling evidence that such methylation is essential for optimal neoplastic proliferation...
  6. ncbi The history of cancer epigenetics
    Andrew P Feinberg
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Rev Cancer 4:143-53. 2004
  7. pmc Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma
    Bin Yang
    Department of Pathology, The Johns Hopkins Medical Institutions, Pathology Building Room 406, 600 North Wolfe Street, Baltimore, MD 21287, USA
    Am J Pathol 163:1101-7. 2003
    ..Recent studies suggest that tumor suppressor genes (TSGs) can also be silenced through epigenetic disruption, such as promoter CpG island methylation, during ..
  8. ncbi A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
    Y Miki
    Department of Medical Informatics, University of Utah Medical Center, Salt Lake City 84132
    Science 266:66-71. 1994
    ..Identification of BRCA1 should facilitate early diagnosis of breast and ovarian cancer susceptibility in some individuals as well as a better understanding of breast cancer biology...
  9. ncbi KiSS-1, a novel human malignant melanoma metastasis-suppressor gene
    J H Lee
    Department of Experimental Pathology, Jake Gittlen Cancer Research Institute, College of Medicine, Pennsylvania State University, Hershey 17033 0850, USA
    J Natl Cancer Inst 88:1731-7. 1996
    ..They further suggest that a melanoma metastasis-suppressor gene(s) is encoded on chromosome 6 or is regulated by genes on chromosome 6...
  10. ncbi Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase
    T Xu
    Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Development 121:1053-63. 1995
    ..Mutations in lats cause dramatic overproliferation phenotypes and various developmental defects in both mosaic animals and homozygous mutants...
  11. pmc Pten dose dictates cancer progression in the prostate
    Lloyd C Trotman
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Institute, New York, New York, USA
    PLoS Biol 1:E59. 2003
    ..Our results provide conclusive genetic support for the notion that PTEN is haploinsufficient in tumor suppression and that its dose is a key determinant in cancer progression...
  12. ncbi Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
    M Kaghad
    Sanofi Recherche, Labege, France
    Cell 90:809-19. 1997
    ..to 1p36, a region frequently deleted in neuroblastoma and other tumors and thought to contain multiple tumor suppressor genes. Our analysis of neuroblastoma cell lines with 1p and p73 loss of heterozygosity failed to detect coding ..
  13. ncbi p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities
    A Yang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 2:305-16. 1998
    ..We demonstrate that these truncated p63 variants can act as dominant-negative agents toward transactivation by p53 and p63, and we suggest the possibility of physiological interactions among members of the p53 family...
  14. ncbi MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
    C Welch
    Children s Cancer Research Institute and Department of Pediatrics, The University of Texas Health Science Center at San Antonio, MC 7784, TX, USA
    Oncogene 26:5017-22. 2007
    ..of advanced stage tumors, is associated with a poor prognosis, and likely leads to the loss of one or more tumor suppressor genes. We show here that microRNA (miRNA)-34a (1p36...
  15. ncbi Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
    Bodo Brueckner
    Division of Epigenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Res 65:6305-11. 2005
    ..Intriguingly, RG108 caused demethylation and reactivation of tumor suppressor genes, but it did not affect the methylation of centromeric satellite sequences...
  16. ncbi Mutations truncating the EP300 acetylase in human cancers
    S A Gayther
    Department of Oncology, University of Cambridge, Cambridge, UK
    Nat Genet 24:300-3. 2000
    ..Our data show that EP300 is mutated in epithelial cancers and provide the first evidence that it behaves as a classical tumour-suppressor gene...
  17. ncbi RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer
    Quek Choon Lau
    Oncology Research Institute and Department of Pathology, National University of Singapore, 10 Medical Drive, Singapore 117597
    Cancer Res 66:6512-20. 2006
    ..Frequent protein mislocalization and methylation could render RUNX3 a valuable marker for early detection and risk assessment...
  18. ncbi A genetic screen in Drosophila for metastatic behavior
    Raymond A Pagliarini
    Howard Hughes Medical Institute, Department of Genetics, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 302:1227-31. 2003
    ..These findings suggest that the oncogenic background of tissues makes a distinct contribution toward metastatic development...
  19. ncbi The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
    J G Gong
    Department of Biology, University of California, San Diego, La Jolla 92093 0322, USA
    Nature 399:806-9. 1999
    ..Our results indicate that c-Abl and p73 are components of a mismatch-repair-dependent apoptosis pathway which contributes to cisplatin-induced cytotoxicity...
  20. ncbi Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors
    D Bilder
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 289:113-6. 2000
    ..scrib, dlg, and lgl show strong genetic interactions. Our data indicate that the three tumor suppressors act together in a common pathway to regulate cell polarity and growth control...
  21. ncbi The paradoxical expression of maspin in ovarian carcinoma
    Anil K Sood
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1109, USA
    Clin Cancer Res 8:2924-32. 2002
    ..These paradoxical results may offer new insights regarding the role of maspin in ovarian cancer progression that may also impact diagnosis and treatment strategies...
  22. ncbi Role for DNA methylation in the control of cell type specific maspin expression
    Bernard W Futscher
    Department of Pharmacology and Toxicology, Bone Marrow Transplant Program, Arizona Cancer Center, The University of Arizona, Tucson, Arizona 85724, USA
    Nat Genet 31:175-9. 2002
    ..These findings indicate that cytosine methylation is important in the establishment and maintenance of cell type restricted gene expression...
  23. ncbi The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation
    R W Justice
    Developmental Biology Center, University of California, Irvine 92717
    Genes Dev 9:534-46. 1995
    ..Our results raise the possibility that homozygous loss of the myotonic dystrophy kinase may contribute to the development of these tumors...
  24. pmc Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
    Naoshi Nishida
    Division of Gastroenterology, Department of Internal Medicine and Charles A Sammons Cancer Center, Dallas, TX, USA
    Hepatology 47:908-18. 2008
    ..However, the group 3 loci showed more dense and frequent methylation in HCV-positive cancers compared with both HBV-positive cancers and virus-negative cancers (P < 0.0001)...
  25. ncbi Cancer genes and the pathways they control
    Bert Vogelstein
    Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University Medical Institutions, Baltimore, Maryland 21231, USA
    Nat Med 10:789-99. 2004
    ..The purposes of this review are to highlight examples of progress in these areas, indicate where knowledge is scarce and point out fertile grounds for future investigation...
  26. ncbi p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours
    A Yang
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 404:99-103. 2000
    ..Our data suggest that there is a marked divergence in the physiological functions of the p53 family members, and reveal unique roles for p73 in neurogenesis, sensory pathways and homeostatic control...
  27. pmc The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44
    H Morrison
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, and University of Karlsruhe, Institute of Genetics, 76021 Karlsruhe, Germany
    Genes Dev 15:968-80. 2001
    ..At low cell density, merlin is phosphorylated, growth permissive, and exists in a complex with ezrin, moesin, and CD44. These data indicate that merlin and CD44 form a molecular switch that specifies cell growth arrest or proliferation...
  28. ncbi Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
    Nabeel Bardeesy
    Department of Adult Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 419:162-7. 2002
    ..Together, our data rationalize several features of PJS polyposis--notably its peculiar histopathological presentation and limited malignant potential--and place Lkb1 in a distinct class of tumour suppressors...
  29. ncbi Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas
    Cinta Mestre-Escorihuela
    Center for Applied Medical Research CIMA, University of Navarra, Avda Pio XII, 55, Pamplona 31008, Spain
    Blood 109:271-80. 2007
    ..oncogenes in B-cell non-Hodgkin lymphoma (B-NHL), but the capability of such technologies to localize tumor suppressor genes within homozygous deletions remains unexplored...
  30. ncbi Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity
    I U Ali
    I U Ali, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD 20892 7332, USA
    J Natl Cancer Inst 91:1922-32. 1999
    ..Further understanding of PTEN/MMAC1 gene mutations in different tumors and the physiologic consequences of these mutations is likely to open up new therapeutic opportunities for targeting this critical gene...
  31. ncbi Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells
    Z Zou
    Division of Cancer Genetics, Dana Farber Cancer Institute, Boston, MA 02115
    Science 263:526-9. 1994
    ..Analysis of human breast cancer specimens revealed that loss of maspin expression occurred most frequently in advanced cancers. These results support the hypothesis that maspin functions as a tumor suppressor...
  32. pmc MicroRNAs in cell proliferation, cell death, and tumorigenesis
    H W Hwang
    Program in Human Genetics and Molecular Biology, The Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, BRB 460C, Baltimore, MD 21205, USA
    Br J Cancer 94:776-80. 2006
    ..It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors...
  33. ncbi Role of the Ras-association domain family 1 tumor suppressor gene in human cancers
    Angelo Agathanggelou
    Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, The Institute of Biomedical Research, University of Birmingham, Edgbaston, Birmingham, United Kingdom
    Cancer Res 65:3497-508. 2005
    In recent years, the list of tumor suppressor genes (or candidate TSG) that are inactivated frequently by epigenetic events rather than classic mutation/deletion events has been growing...
  34. pmc A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
    Joyce E Ohm
    Cancer Biology Division, The Sidney Kimmel Comprehensive Cancer Center
    Nat Genet 39:237-42. 2007
    ..cancers, which often show aberrant promoter CpG island hypermethylation and transcriptional silencing of tumor suppressor genes and pro-differentiation factors...
  35. ncbi Frequently methylated tumor suppressor genes in head and neck squamous cell carcinoma
    Kristi L Bennett
    Department of Molecular Genetics, The Ohio State University, Columbus, Ohio, USA
    Cancer Res 68:4494-9. 2008
    ..Interestingly, all of the candidates identified may be involved in the transforming growth factor beta signaling pathway, which is often disrupted in HNSCC...
  36. ncbi Role for the p53 homologue p73 in E2F-1-induced apoptosis
    M Irwin
    Dana Farber Cancer Institute and Brigham and Womens Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 407:645-8. 2000
    ..Disruption of p73 function inhibited E2F-1-induced apoptosis in p53-defective tumour cells and in p53-/- mouse embryo fibroblasts. We conclude that activation of p73 provides a means for E2F-1 to induce death in the absence of p53...
  37. ncbi The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium
    M I Lerman
    Laboratory of Immanobiology, National Cancer Institute, Frederick Cancer Research and Development Center, Maryland 21702, USA
    Cancer Res 60:6116-33. 2000
    ..to further define a approximately 630-kb lung cancer homozygous deletion region harboring one or more tumor suppressor genes (TSGs) on chromosome 3p21.3...
  38. pmc The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis
    K Dreijerink
    Laboratory of Immunobiology and Intramural Research Support Program, Science Applications International Corporation, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 98:7504-9. 2001
    ..Mutant RASSF1A had reduced growth suppression activity significantly. These data suggest that RASSF1A is the candidate renal TSG gene for the 3p21.3 region...
  39. ncbi Genetic and epigenetic alterations of the cell cycle regulators and tumor suppressor genes in pediatric osteosarcomas
    Ana Patino-Garcia
    Department of Pediatrics, University of Navarra, Pamplona, Spain
    J Pediatr Hematol Oncol 25:362-7. 2003
    To analyze the genetic and epigenetic alterations affecting the RB1, TP53, p16INK4, and p21WAF1 tumor suppressor genes, loss of heterozygosity (LOH) at 3q and 18q, and the clinical variables of a series of Spanish children with ..
  40. ncbi Association of aberrant methylation of tumor suppressor genes with tumor aggressiveness and BRAF mutation in papillary thyroid cancer
    Shuiying Hu
    Department of Medicine, Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Int J Cancer 119:2322-9. 2006
    ..cell lines, we first demonstrated the functional consequence of methylation of several recently identified tumor suppressor genes, including those for tissue inhibitor of metalloproteinase-3 (TIMP3), SLC5A8, death-associated protein ..
  41. pmc Simultaneous down-regulation of tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A in primary non-small cell lung cancer
    Vera N Senchenko
    Laboratory of Structural and Functional Genomics, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
    BMC Cancer 10:75. 2010
    ..Three bona fide lung cancer tumor suppressor genes namely RBSP3 (AP20 region),NPRL2 and RASSF1A (LUCA region) were identified in the 3p21.3 region...
  42. ncbi DNA methylation and gene silencing in cancer: which is the guilty party?
    Susan J Clark
    Sydney Cancer Centre, Kanematsu Laboratories, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia
    Oncogene 21:5380-7. 2002
    ....
  43. ncbi Control of autophagy by oncogenes and tumor suppressor genes
    M C Maiuri
    INSERM, U848, Apoptosis Cancer and Immunity, F 94805 Villejuif, France
    Cell Death Differ 16:87-93. 2009
    ..Altogether, the current state-of-the art suggests a complex relationship between cancer and deregulated autophagy that must be disentangled by further in-depth investigation...
  44. ncbi p53, p63 and p73--solos, alliances and feuds among family members
    U M Moll
    Department of Pathology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Biochim Biophys Acta 1552:47-59. 2001
    ..In this review, we attempt to present an overview of the current status of this fast moving field...
  45. ncbi Does aneuploidy cause cancer?
    Beth A A Weaver
    Ludwig Institute for Cancer Research, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0670, USA
    Curr Opin Cell Biol 18:658-67. 2006
    ..Cumulatively, the current evidence suggests that aneuploidy promotes tumorigenesis, at least at low frequency, but a definitive test has not yet been reported...
  46. pmc Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes
    Sharmistha Pal
    Department of Molecular and Cellular Biochemistry, Ohio State University College of Medicine, Columbus, OH 43210, USA
    Mol Cell Biol 24:9630-45. 2004
    ..These findings suggest that the BRG1- and hBRM-associated PRMT5 regulates cell growth and proliferation by controlling expression of genes involved in tumor suppression...
  47. ncbi An anti-apoptotic role for the p53 family member, p73, during developmental neuron death
    C D Pozniak
    Center for Neuronal Survival, Brain Tumor Research Center, Montreal Neurological Institute, McGill University, Montreal, Canada H3A 2B4
    Science 289:304-6. 2000
    ..Thus, truncated p73 is an essential anti-apoptotic protein in neurons, serving to counteract the pro-apoptotic function of p53...
  48. ncbi Mutations of the human PTEN gene
    D Bonneau
    Department of Medical Genetics, University of Poitiers, Poitiers, France
    Hum Mutat 16:109-22. 2000
    ..A mutagenesis by insertion-deletion in repetitive elements is however specifically observed in endometrial carcinomas...
  49. ncbi Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation
    Weiwei Feng
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Cancer 112:1489-502. 2008
    Imprinted tumor suppressor genes may be particularly important in the pathogenesis of ovarian cancer...
  50. pmc Two new p73 splice variants, gamma and delta, with different transcriptional activity
    V De Laurenzi
    Biochemistry Laboratory, Istituto Dermopatico dell Immacolata IRCCS, Department of Experimental Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
    J Exp Med 188:1763-8. 1998
    ..The relative expression level of each splice variant may modulate p73 transcriptional and growth suppression activities by affecting heterodimer formation...
  51. ncbi Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53
    T J Grob
    Department of Clinical Research and Medical Oncology Hematology, University and Inselspital, Berne, Switzerland
    Cell Death Differ 8:1213-23. 2001
    ..Our data also suggest that increased expression of Delta Np73, functionally inactivating p53, could be involved in tumorogenesis. An extensive analysis of the expression pattern of Delta Np73 in primary tumours would clarify this issue...
  52. pmc The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclin D1 accumulation
    Latha Shivakumar
    Department of Cell Biology, UT Southwestern Medical Center, Dallas, Texas 75390 9039, USA
    Mol Cell Biol 22:4309-18. 2002
    ..These results strongly suggest that RASSF1A is an important human tumor suppressor protein acting at the level of G(1)/S-phase cell cycle progression...
  53. ncbi Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state
    Kelly M McGarvey
    Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, 1650 Orleans Street, Baltimore, MD 21231, USA
    Cancer Res 66:3541-9. 2006
    ..This finding has important implications for the translational goal of reactivating aberrantly silenced cancer genes as a therapeutic maneuver...
  54. ncbi Tumor suppressor genetics
    Shannon R Payne
    Fred Hutchinson Cancer Research Center, Seattle, WA 90109, USA
    Carcinogenesis 26:2031-45. 2005
    The observation that mutations in tumor suppressor genes can have haploinsufficient, as well as gain of function and dominant negative, phenotypes has caused a reevaluation of the 'two-hit' model of tumor suppressor inactivation...
  55. ncbi Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma
    Tamotsu Kuroki
    Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 63:3724-8. 2003
    Promoter hypermethylation is an alternative way to inactivate tumor suppressor genes in cancer. Alterations of chromosome 3p are frequently involved in many types of cancer, including esophageal squamous cell carcinoma...
  56. ncbi Detection and interpretation of altered methylation patterns in cancer cells
    Toshikazu Ushijima
    Carcinogenesis Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Nat Rev Cancer 5:223-31. 2005
    ..What techniques can be used to identify new tumour suppressors and diagnostic markers?..
  57. pmc Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes
    G Strathdee
    Cancer Research Campaign Department of Medical Oncology, CRC Beatson Laboratories, Glasgow University, Glasgow G61 1BD, United Kingdom
    Am J Pathol 158:1121-7. 2001
    ..suggests that aberrant methylation of CpG islands is a major pathway leading to the inactivation of tumor suppressor genes and the development of cancer...
  58. ncbi FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex
    Raman Kumar
    Breast Cancer Genetics Group, Dame Roma Mitchell Cancer Research Laboratories, Department of Medicine, University of Adelaide and Hanson Institute, Institute of Medical and Veterinary Science Adelaide, Australia
    Cancer Res 65:11304-13. 2005
    ..We propose that FBXO31 functions as a tumor suppressor by generating SCF(FBXO31) complexes that target particular substrates, critical for the normal execution of the cell cycle, for ubiquitination and subsequent degradation...
  59. ncbi TSGDB: a database system for tumor suppressor genes
    Yanming Yang
    University of Florida, Gainesville, FL, USA
    Bioinformatics 19:2311-2. 2003
    A Web-based database system was constructed and implemented that contains 174 tumor suppressor genes. The database homepage was created to accommodate these genes in a pull-down window so that each gene can be viewed individually in a ..
  60. ncbi Tumor suppressors: linking cell polarity and growth control
    A Wodarz
    Institut fur Genetik, Heinrich Heine Universitat Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Curr Biol 10:R624-6. 2000
    The Drosophila tumor suppressor genes scribble, discs large and lethal giant larvae appear to act in a common pathway...
  61. ncbi Maspin expression in invasive breast cancer: association with other prognostic factors
    Syed K Mohsin
    Breast Center, Baylor College of Medicine, Houston, Texas 77030, USA
    J Pathol 199:432-5. 2003
    ..Additional studies are needed to evaluate further this expression profile of maspin in breast cancer...
  62. ncbi Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma
    Chad A Livasy
    Department of Pathology and Lab Medicine, University of North Carolina, Chapel Hill, NC 27599 7525, USA
    Mod Pathol 19:264-71. 2006
    ..These findings should further assist in the identification of basal-like carcinomas in clinical specimens, facilitating treatment and epidemiologic studies of this tumor subtype...
  63. ncbi Evasion of a single-step, chemotherapy-induced senescence in breast cancer cells: implications for treatment response
    Lynne W Elmore
    Department of Pathology, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298 230, USA
    Clin Cancer Res 11:2637-43. 2005
    ..Here, we test the hypothesis that evasion of senescence confers resistance to chemotherapeutic drugs and ionizing radiation...
  64. ncbi p73: Friend or foe in tumorigenesis
    Gerry Melino
    Biochemistry Laboratory, IDI IRCCS, c o Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, 00133 Rome, Italy
    Nat Rev Cancer 2:605-15. 2002
  65. ncbi Reduced FEZ1/LZTS1 expression and outcome prediction in lung cancer
    Daisuke Nonaka
    Department of Pathology, Istituto Nazionale Tumori, Milan, Italy
    Cancer Res 65:1207-12. 2005
    Chromosomal deletions are often observed in lung cancers suggesting that inactivation of tumor suppressor genes plays an important role in the development of this neoplasm...
  66. ncbi Aberrant promoter hypermethylation and silencing of the critical 3p21 tumour suppressor gene, RASSF1A, in Chinese oesophageal squamous cell carcinoma
    Michelle Ly Wong
    Department of Pathology, The University of Hong Kong, Hong Kong, PR China
    Int J Oncol 28:767-73. 2006
    ..Our results show that RASSF1A hypermethylation in ESCC has epidemiological/ethnic differences, and suggest that Chinese ESCC may result from different pathogenetic mechanisms...
  67. ncbi Aberrant methylation of multiple tumor suppressor genes in acute myeloid leukemia
    Cumhur G Ekmekci
    Genetics, Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey
    Am J Hematol 77:233-40. 2004
    ..More recent studies identified methylation of other tumor suppressor genes, DAP-kinase and SOCS1, singly in AML...
  68. ncbi Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers
    Jane E Armes
    Molecular Pathology Laboratory, Victorian Breast Cancer Research Consortium, Australia
    Oncogene 23:5697-702. 2004
    ..These candidate TSGs may constitute some of the molecular drivers of chromosome arm 8p loss in breast carcinogenesis...
  69. ncbi Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas
    Yuichi Wakabayashi
    Department of Gene Regulation, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1 757, Niigata 951 8122, Japan
    Biochem Biophys Res Commun 301:598-603. 2003
    ..Introduction of Rit1 into HeLa cells lacking Rit1 expression suppressed cell growth. These results indicate that loss-of-function mutations of Rit1 contribute to mouse lymphomagenesis and possibly to human cancer development...
  70. ncbi Frequent epigenetic inactivation of RASSF1A and BLU genes located within the critical 3p21.3 region in gliomas
    Luke Hesson
    Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham, Birmingham B15 2TT, UK
    Oncogene 23:2408-19. 2004
    ..We then investigated the methylation status of three other candidate 3p21.3 tumor suppressor genes. CACNA2D2 and SEMA3B were not frequently methylated, but the BLU gene located just centromeric to RASSF1 ..
  71. ncbi Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant delta-6 of the candidate tumour suppressor LUCA-15/RBM5
    Mirna Mourtada-Maarabouni
    School of Life Sciences, Keele University, Keele, ST5 5BG, UK
    Genes Cells 8:109-19. 2003
    ..Many genes mapping to this region have recently been identified, including the LUCA-15/RBM5 gene...
  72. ncbi Oocyte growth-dependent progression of maternal imprinting in mice
    Hitoshi Hiura
    Department of Bioscience, Tokyo University of Agriculture, 1 1 1, Sakuragaoka, Setagaya Ku, Tokyo 156 8502, Japan
    Genes Cells 11:353-61. 2006
    ..From these results, we concluded that DNA methylation is established with oocyte size dependent manner, not with aging of mice...
  73. ncbi Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
    D Liaw
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Nat Genet 16:64-7. 1997
    ..Thus, PTEN appears to behave as a tumour suppressor gene in the germline. Our data also imply that PTEN may play a role in organizing the relationship of different cell types within an organ during development...
  74. ncbi Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer
    O Aguilera
    Instituto de Investigaciones Biomédicas Alberto Sols and Departamento de Bioquímica, Facultad de Medicina, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Oncogene 25:4116-21. 2006
    Colorectal cancer is a major cause of cancer death worldwide. A number of key oncogenes and tumor suppressor genes have been proposed to drive progression from healthy colonic epithelia to malignant tumors, including members of the Wnt/..
  75. ncbi Screening of new tumor suppressor genes in sporadic colorectal cancer patients
    Xiaoliang Wang
    Department of General Surgery, Shanghai Jiao Tong University Affiliated First People s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
    Hepatogastroenterology 55:2039-44. 2008
    ..The purpose of this study was to screen for unknown tumor suppressor genes (TSGs) in patients with sporadic CRC.
  76. ncbi Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies
    J Iqbal
    Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Leukemia 23:1139-51. 2009
    ..ATG5, an essential gene for autophagy and AIM1, a gene implicated in melanoma, may also participate in the functional abnormalities...
  77. ncbi LKB1 modulates lung cancer differentiation and metastasis
    Hongbin Ji
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 448:807-10. 2007
    ..These studies establish LKB1 as a critical barrier to pulmonary tumorigenesis, controlling initiation, differentiation and metastasis...
  78. ncbi Impaired microRNA processing enhances cellular transformation and tumorigenesis
    Madhu S Kumar
    MIT Center for Cancer Research, Cambridge, Massachusetts 02139, USA
    Nat Genet 39:673-7. 2007
    ..Furthermore, conditional deletion of Dicer1 enhanced tumor development in a K-Ras-induced mouse model of lung cancer. Overall, these studies indicate that abrogation of global miRNA processing promotes tumorigenesis...
  79. pmc The H19 locus acts in vivo as a tumor suppressor
    Tomomi Yoshimizu
    Department of Genetics and Development, Institut Cochin, University Paris Descartes, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Institut National de la Sante et de la Recherche Medicale U567, Paris 75014, France
    Proc Natl Acad Sci U S A 105:12417-22. 2008
    ..The H19 locus thus clearly displays a tumor suppressor effect in mice...
  80. pmc E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers
    G Berx
    Laboratory of Molecular Biology, University of Ghent, Belgium
    EMBO J 14:6107-15. 1995
    ..These findings offer a molecular explanation for the typical scattered tumour cell growth in infiltrative lobular breast cancer...
  81. ncbi The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2
    Zhi Wang
    Department of Urology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9110, USA
    J Biol Chem 277:12622-31. 2002
    ..Thus, DOC-2/DAB2 and DIP1/2 appear to represent a unique negative regulatory complex that maintains cell homeostasis...
  82. ncbi Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors
    J A Biegel
    The Children s Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania School of Medicine, 19104, USA
    Cancer Res 59:74-9. 1999
    ..These studies suggest that INI1 is a tumor suppressor gene involved in rhabdoid tumors of the brain, kidney, and other extrarenal sites...
  83. ncbi Disabled-2 inactivation is an early step in ovarian tumorigenicity
    Z Fazili
    Department of Biochemistry and Winship Cancer Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Oncogene 18:3104-13. 1999
    ..Thus, this study indicates that the loss of Dab2 expression is correlated with tumorigenicity of the cells disregarding the grade of the tumors, and loss of Dab2 expression is an early event in ovarian malignancies...
  84. ncbi The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
    Eunice H Y Chan
    Department of Cell Biology, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Oncogene 24:2076-86. 2005
    ..Although the function of this pathway remains poorly understood in mammals, it is intriguing that, in Drosophila, it has been linked to development and tissue homeostasis...
  85. ncbi Mutations in the APC tumour suppressor gene cause chromosomal instability
    R Fodde
    Department of Human and Clinical Genetics, and Center for Biomedical Genetics, Leiden University Medical Center, PO Box 9503, 2300 RA Leiden, The Netherlands
    Nat Cell Biol 3:433-8. 2001
    ..We conclude that loss of APC sequences that lie C-terminal to the beta-catenin regulatory domain contributes to chromosomal instability in colorectal cancer...
  86. ncbi Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma
    Keishi Yamashita
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, 720 Rutland Avenue, Ross Building 818, Baltimore, MD 21205, USA
    Cancer Cell 2:485-95. 2002
    We performed a comprehensive survey of commonly inactivated tumor suppressor genes in esophageal squamous cell carcinoma (ESCC) based on functional reactivation of epigenetically silenced tumor suppressor genes by 5-aza-2'-deoxycytidine ..
  87. ncbi p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene
    S Matsuoka
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030 USA
    Genes Dev 9:650-62. 1995
    ..The discovery of a new member of the p21CIP1 inhibitor family with novel structural features and expression patterns suggests a complex role for these proteins in cell cycle control and development...
  88. ncbi The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma
    P N Kongkham
    Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumor Research Centre, Toronto, Ontario, Canada M5G 1X8
    Oncogene 29:3017-24. 2010
    ..secreted frizzled-related protein 1, 2 and 3 (SFRP1, SFRP2 and SFRP3) family of WNT inhibitors as putative tumor suppressor genes silenced by promoter region methylation in MB...
  89. ncbi The CpG island of the novel tumor suppressor gene RASSF1A is intensely methylated in primary small cell lung carcinomas
    R Dammann
    Department of Biology, Beckman Research Institute, City of Hope Cancer Center, Duarte, California 91010, USA
    Oncogene 20:3563-7. 2001
    ..None of the SCLCs showed evidence for methylation of the CpG island of RASSF1C. The results suggest that hypermethylation of the CpG island promoter of the RASSF1A gene is associated with SCLC pathogenesis...
  90. pmc TAp73 knockout shows genomic instability with infertility and tumor suppressor functions
    Richard Tomasini
    The Campbell Family Institute for Breast Cancer Research, Princess Margaret Hospital, Toronto, Ontario M5G 2C1, Canada
    Genes Dev 22:2677-91. 2008
    ..Hence, TAp73 isoforms exert tumor-suppressive functions and indicate an emerging role for Trp73 in the maintenance of genomic stability...
  91. pmc Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis
    Minjung J Kim
    Center for Advanced Biotechnology and Medicine and Department of Neuroscience, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 99:2884-9. 2002
    ..Our findings underscore the significance of interactions between tissue-specific regulators such as Nkx3.1 and broad-spectrum tumor suppressors such as Pten in contributing to the distinct phenotypes of different cancers...
  92. ncbi The role of Notch in tumorigenesis: oncogene or tumour suppressor?
    Freddy Radtke
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland
    Nat Rev Cancer 3:756-67. 2003
    ..However, there is mounting evidence that Notch signalling is not exclusively oncogenic. It can instead function as a tumour suppressor...
  93. ncbi Aberrant methylation of candidate tumor suppressor genes in neuroblastoma
    Jasmien Hoebeeck
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Cancer Lett 273:336-46. 2009
    ..study, we performed methylation-specific PCR (MSP) to investigate the methylation status of 10 selected tumor suppressor genes in neuroblastoma...
  94. ncbi Genistein mediated histone acetylation and demethylation activates tumor suppressor genes in prostate cancer cells
    Nobuyuki Kikuno
    Department of Urology, Veterans Affairs Medical Center and University of California, San Francisco, San Francisco, CA 94121, USA
    Int J Cancer 123:552-60. 2008
    ..We tested the hypothesis that genistein activates expression of several aberrantly silenced tumor suppressor genes (TSGs) that have unmethylated promoters such as PTEN, CYLD, p53 and FOXO3a...
  95. ncbi Perturbations of the AKT signaling pathway in human cancer
    Deborah A Altomare
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Oncogene 24:7455-64. 2005
    ..The latter include disorders caused by germline mutations of certain tumor suppressor genes, that is, PTEN, TSC2/TSC1, LKB1, NF1, and VHL, encoding proteins that intersect with the AKT pathway...
  96. ncbi The RASSF1A tumor suppressor gene is inactivated in prostate tumors and suppresses growth of prostate carcinoma cells
    Igor Kuzmin
    Intramural Research Support Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Maryland 21702, USA
    Cancer Res 62:3498-502. 2002
    ..Suppression of cell growth in vitro was demonstrated after the reintroduction of RASSF1A-expressing construct into LNCaP prostate carcinoma cells. Our data implicate the RASSF1A gene in human prostate tumorigenesis...
  97. pmc Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
    B Kwabi-Addo
    Department of Pathology and Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 98:11563-8. 2001
    ..This observation provides a potential explanation for the discordance in rates of loss of heterozygosity at 10q23 and biallelic PTEN inactivation observed in prostate cancer and many human malignancies...
  98. ncbi Association of maspin expression with the malignancy grade and tumor vascularization in breast cancer tissues
    T Hojo
    Growth Factor Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan
    Cancer Lett 171:103-10. 2001
    ..These results suggest that maspin production in myoepithelial cells could downregulate the malignant phenotype of breast cancer...
  99. pmc Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain
    S W Chi
    Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    EMBO J 18:4438-45. 1999
    ..However, the SAM-like C-terminal domains of p73 and p63 are monomeric and do not interact with one another, suggesting that this domain may interact with additional, as yet uncharacterized proteins in a signaling and/or regulatory role...
  100. pmc A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation
    Jharna Datta
    Department of Molecular and Cellular Biochemistry, College of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Cancer Res 69:4277-85. 2009
    Reactivation of silenced tumor suppressor genes by 5-azacytidine (Vidaza) and its congener 5-aza-2'-deoxycytidine (decitabine) has provided an alternate approach to cancer therapy...
  101. ncbi TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma
    Hong Lok Lung
    Department of Biology and Center for Cancer Research, Hong Kong University of Science and Technology, Kowloon, Hong Kong SAR, People s Republic of China
    Cancer Res 66:9385-92. 2006
    ..These findings suggest that TSLC1 is a tumor suppressor gene in NPC, which is significantly associated with lymph node metastases...

Research Grants72

  1. Genistein, microRNAs and kidney cancer
    Rajvir Dahiya; Fiscal Year: 2013
    ..Second genistein induced tumor suppressor miRNAs can activate the transcription of tumor suppressor genes by binding to the 5'upstream region of the gene or activate translation by binding to the 5'..
  2. Role of Diabetes in Development of Renal Cell Carcinoma
    SAMY LEWIZ HABIB; Fiscal Year: 2013
    ..One of the tumor suppressor genes involved in renal carcinogenesis is tuberous sclerosis gene (TSC2), which encodes tumor suppressor protein,..
  3. Chemical modulators of Tet-family proteins
    Anjana Rao; Fiscal Year: 2010
    ..In cancer, DNA methylation has been linked to aberrant silencing of tumor suppressor genes;in the central nervous system (CNS), it has been implicated, among other things, in learning, memory and ..
  4. Genistein and Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2010
    ..2) To evaluate expression of steroid receptor genes and tumor suppressor genes at the mRNA and protein levels using Northern blot, and Western blotting analysi respectively...
  5. Prolactin as a Growth Factor in Breast Cancer
    Nira Ben-Jonathan; Fiscal Year: 2013
    ..many causes, including drug efflux, inactivation, altered expression of pro/anti-apoptotic proteins or tumor suppressor genes, and increased DNA repair mechanisms...
  6. MECHANISMS OF EUKARYOTIC TRANSCRIPTIONAL REGULATION
    Michael R Green; Fiscal Year: 2013
    ..A specific objective of the application is to study the mechanism by which tumor suppressor genes become transcriptionally silenced during cancer development.
  7. Transgenerational effects of maternal high fat diet during pregnancy on breast ca
    Leena A Hilakivi-Clarke; Fiscal Year: 2013
    ..21% of these genes were polycomb target genes (PcGTs), which in turn included some tumor suppressor genes (TSGs), suggesting that maternal diet during pregnancy, including consumption of a HF diet, may induce ..
  8. SATB1-dependent epigenetic regulation of leukemia initiating cells
    Britta Will; Fiscal Year: 2011
    ..Our preliminary data make SATB1 a potential paradigm for epigenetic regulation of tumor suppressor genes in leukemia stem cells...
  9. MicroRNAs in the Progression and Metastisis of Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2013
    ..Based on these novel observations, we hypothesize that down-regulation of a set of microRNAs can inhibit tumor suppressor genes or activate oncogenes and re-expression of these miRNAs can reverse these effects thereby regulating ..
  10. MECHANISMS OF INTESTINAL TUMORIGENESIS
    Vincent W Yang; Fiscal Year: 2013
    ..to CRC include amplification, silencing, and activating or inactivating mutations of protooncogenes or tumor suppressor genes (TSGs), respectively...
  11. Mechanisms of tumor suppressor gene reactivation in colon cancer by berries
    Li Shu Wang; Fiscal Year: 2013
    ..in human colon tumor cells, which led to demethylation and reactivation of hypermethylation-silenced tumor suppressor genes such as p16...
  12. Integrative Pathway Analysis of Epigenomic/transcriptional Alteration in HNSCC
    Joseph A Califano; Fiscal Year: 2010
    ..epigenetic alteration in human cancers has been focused on discovery of specific promoter hypermethylated tumor suppressor genes. We have recently demonstrated that genome-wide epigenetic unmasking and promoter hypomethylation ..
  13. Characterization of Genetic Abnormalities in MDS and Their Clinical Impact
    Rafael Bejar; Fiscal Year: 2013
    ..b>Tumor suppressor genes known to be mutated in MDS and other myeloid disorders will be sequenced in this cohort using the Roche/..
  14. DNA methylation alterations in response to pesticides exposure
    Lifang Hou; Fiscal Year: 2010
    ..OPs), the most commonly used insecticides in the US, to increased promoter methylation of several tumor suppressor genes in blood DNA. We further confirmed this finding in vitro, using human blood cells treated with OPs...
  15. 2011 Epigenetics Gordon Research Conference
    Marisa S Bartolomei; Fiscal Year: 2011
    ..Epigenetic misregulation contributes to cancer through silencing of tumor suppressor genes. Disease states including imprinting disorders and Rett syndrome have an epigenetic basis, as do aspects ..
  16. Mechanisms of cancer initiation by TRIM32
    Molly F Kulesz-Martin; Fiscal Year: 2012
    ..extend abnormal cell survival and promote further changes (activation of cancer genes and inactivation of tumor suppressor genes) provides a basis for novel selective, less toxic molecular-targeted prevention and therapy of skin ..
  17. Nanotheranostics for Early Colorectal Cancer Detection and Treatment
    Jeffrey S Souris; Fiscal Year: 2013
    ..arise via multiple independent pathways that include mutations and alterations in numerous oncogenes and tumor suppressor genes (e.g., APC gene inactivation, K-ras oncogene activation, and p53 mutation)...
  18. Metagenomic profiling of oral polymicrobial flora in head and neck cancers
    Charis Eng; Fiscal Year: 2011
    ..specific microbial "consortia" influencing inflammation with consequent epigenetic alterations of target tumor suppressor genes in HNSCC;(3) To functionally validate the involvement of MAD2 and/or MDR1 in HNSCC tumor suppression...
  19. Generation of Human iPS Cells via Non-integrating Vectors
    Wen Shu Wu; Fiscal Year: 2010
    ..and mice derived from iPS cells develop tumors, mainly through reactivation of c-Myc and inactivation of tumor suppressor genes resulting from viral insertional mutagenesis...
  20. A Validated Resource of Thyroid Cancer Cell Lines for Pathway Discovery
    JEFFREY ALLEN KNAUF; Fiscal Year: 2010
    ..platforms, mass spectrometry genotyping, CGH array analysis, mutational screen of key oncogenes and tumor suppressor genes and high throughput pathway activation analysis by Western blotting)...
  21. Does the extreme variability of methadone metabolism have an epigenetic cause?
    Gavin R Schnitzler; Fiscal Year: 2010
    ..For instance, these modifications are often associated with the aberrant loss of mRNA for important tumor suppressor genes, including retinoblastoma protein (pRB) and breast cancer associated protein 1 (BRCA1)...
  22. Energy Restrction and Mammary Cancer
    Henry J Thompson; Fiscal Year: 2013
    ..Since DER has direct effects, based on our ongoing work, on at least 4 tumor suppressor genes (LKB1, TSC2, PTEN, and p53) that are misregulated during the development of cancer, it is likely that work ..
  23. Vitamin D in Prostate Cancer: Tumor Vasculature Effects
    Candace S Johnson; Fiscal Year: 2012
    ..without alteration in DNA gene sequence and lead to transcriptional gene silencing and inactivation of tumor suppressor genes in human cancer...
  24. Dietary HDAC Inhibitors in Colon Cancer Prevention
    Roderick H Dashwood; Fiscal Year: 2012
    ..project examines how chemoprotective factors in broccoli and garlic, working through epigenetic mechanisms, can turn on tumor suppressor genes, thereby causing colon cancer cells to halt their growth and/or rapidly undergo cell suicide.
  25. Oncogene cooperation in glioma genesis
    Wei Zhang; Fiscal Year: 2013
    ..Cancer development and progression involve activation of multiple oncogenes and inactivation of multiple tumor suppressor genes. Many oncogenes enhance cell proliferation, inhibit apoptosis, and promote angiogenesis and invasion (the ..
  26. Recombination Repair Complex in Human Cells
    Richard Fishel; Fiscal Year: 2013
    ..Genome instability is common to all tumors and is thought to drive the alteration of oncogenes, tumor suppressor genes as well as expression and epigenetic changes...
  27. IL-15 Characterization Through Experimental Immunology
    Michael A Caligiuri; Fiscal Year: 2013
    ..involves a process of non-random methylation across the genome, a process that silences putative tumor suppressor genes and is highly responsive to hypomethylation therapy...
  28. ROLES AND REGULATION OF P53
    Carol Prives; Fiscal Year: 2013
    ..collaborative approach to understand the roles of mutant p53, p53 family member's p63 and p73 and new tumor suppressor genes in cancer...
  29. Defining Novel Biomarkers for Cervical Cancer Etiology and Progression by Quantit
    Erin Siegel; Fiscal Year: 2010
    ..often early events in the cancer process and are responsible, in part, for transcriptional repression of tumor suppressor genes (TSGs) during tumorigenesis...
  30. Role of Kruppel-Like Factor 4 in Wnt and Notch Signaling in the Intestinal Tract
    Amr Ghaleb; Fiscal Year: 2010
    ..These genes include tumor suppressor genes and oncogenes...
  31. Factors for Epigenetic Silencing of Lung Cancer Genes
    Steven A Belinsky; Fiscal Year: 2013
    ..Studies in this competitive renewal will test the hypothesis that the propensity for silencing of tumor suppressor genes in the respiratory epithelium of chronic smokers by promoter hypermethylation is influenced by sequence ..
  32. Reactivation of Tumor Suppressor Genes in Breast Cancer by Dietary Supplements as
    Zhongfa Liu; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Reactivation of Tumor Suppressor Genes in Breast Cancer by Dietary Supplements Hypermethylation-silenced tumor suppressor gene (TSG) is a hallmark of most cancers, including breast cancer and has been ..
  33. INFIDELITY OF CYTOSINE METHYLATION AND HUMAN CANCER
    Lawrence C Sowers; Fiscal Year: 2013
    ..Promoter hypermethylation (epigenetic) leads to the silencing of multiple tumor suppressor genes. Very little is known about mechanisms by which methylation patterns are altered...
  34. Role of vitamin D receptor in DNA repair
    Dennis H Oh; Fiscal Year: 2013
    ..to correlate VDR with levels of key DNA repair proteins as well as perform a mutational analysis on key tumor suppressor genes to test if VDR loss is associated with an abnormal mutator phenotype...
  35. Advanced Immunocytochemistry, In Situ Hybridization and Live Cell Imaging Course
    TERRI I GRODZICKER; Fiscal Year: 2013
    ..The techniques will be used to characterize copy number changes of oncogenes and tumor suppressor genes on the DNA-level using spectral karyotyping and comparative genomic hybridization (CGH), and to analyze ..
  36. CSHL Cell Death Conference
    David J Stewart; Fiscal Year: 2013
    ..Some of the genes that regulate programmed cell death include oncogenes and tumor suppressor genes, providing a link between deregulation of cell death pathways and cancer...
  37. Role of Splicing Factors in Breast Cancer
    OLGA ANCZUKOW-CAMARDA; Fiscal Year: 2013
    ..This plan will establish the basis for my independent research program, in which I plan to contribute to the development of new cancer therapies based on modulating the expression and activity of splicing factors or their targets. ..
  38. Gene Expression Patterns in Human Tumors Identified Using Transcript Sequencing
    Charles M Perou; Fiscal Year: 2013
    ..to the identification of novel subtypes of tumors with distinct patient outcomes and has identified new tumor suppressor genes. In the pilot phase of The Cancer Genome Atlas (TCGA) project, multiple platforms were used including ..
  39. Identification of LSD1 inhibitors targeting epigenetic regulation in tumor cells
    Patrick M Woster; Fiscal Year: 2013
    ..at gene promoters, and aberrant demethylation of this mark by LSD1 may broadly repress the expression of tumor suppressor genes that are important in human cancer...
  40. Regulation of Cell Growth by RNA Binding Proteins
    Nikolai A Timchenko; Fiscal Year: 2012
    ..We will test the hypothesis that CUGBP1-mediated elevation of HDAC1 inhibits promoters of liver specific tumor suppressor genes such as C/EBPa...
  41. The Role of de novo Cytosine DNA Methyltransferases 3a &3b in Gene Methylation
    Ivo Teneng; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Inactivation of tumor suppressor genes is an important step in the development of all forms of human cancer...
  42. Bacterial and Chemical Carcinogens in Gastric Oncogenesis
    D Scott Merrell; Fiscal Year: 2012
    ..pylori up-regulates pro-inflammatory genes and down-regulates DNA repair genes and tumor suppressor genes (TSG);the resulting weakening of normal repair mechanisms of epithelial cells may potentiate the effects ..
  43. Synthesis, StructUre and Replication of Carcirogen-Modified Oligonucleotides
    Carmelo J Rizzo; Fiscal Year: 2013
    ..Frameshift inactivation of tumor suppressor genes is observed in many human colorectal cancers...
  44. COBRE Center for Cancer Research Development
    Bharat Ramratnam; Fiscal Year: 2013
    ..investigator with his first RO1, will pursue a new line of research centered on gastrokine-1/2, two novel tumor suppressor genes identified during his first cycle of COBRE funding...
  45. Development of sd-rxRNAs as Therapy for Retinoblastoma and Other Malignancies
    Pamela Pavco; Fiscal Year: 2012
    ..Perhaps most significantly, this work has revealed that cancers can develop in response to mutations in tumor suppressor genes. Tumor suppressor mutations account for ~80% of all cancer mutations, but unlike activating mutations in ..
  46. Detection of Tumor DNA in Plasma from Carolina Breast Cancer Study Patients
    KATHLEEN CONWAY DORSEY; Fiscal Year: 2013
    ..and genome stability, and methylation of cytosine residues in CpG islands of gene promoters can silence tumor suppressor genes critical to breast cancer development and progression...
  47. Walleye Dermal Sarcooma Virus Accessory Protein Function
    Sandra L Quackenbush; Fiscal Year: 2012
    ..This generally develops in a multistep process that involves mutations in oncogenes and tumor suppressor genes. The understanding of this process has been greatly enhanced through the study of tumor viruses...
  48. Understanding and Eliminating Oncogenic EGFR Signaling in Malignant Glioma
    Alain Charest; Fiscal Year: 2013
    ..human tumors, that is overexpression of EGFR along with loss of function of the p16lnk4a/p19ARF and PTEN tumor suppressor genes. We hypothesize that investigating global EGFR signaling pathways in our model using phosphoproteomic ..
  49. The Regulatory Role of PTEN on CXCR4-mediated Metastasis in Prostate Cancer Cells
    MAHANDRANAUTH ANAND CHETRAM; Fiscal Year: 2011
    The development of prostate cancer is due to the loss of tumor suppressor genes and activation of proto-oncogene...
  50. Epigenetic Regulation of Medulloblastoma
    LAURIE L JACKSON-GRUSBY; Fiscal Year: 2012
    ..To approach this question, we are utilizing a mouse model harboring mutations in two tumor suppressor genes, Ptch and p53, that when mutated lead to a highly penetrant and lethal medulloblastoma...
  51. Mechanisms of RelA Activation in Cancer
    Paul J Chiao; Fiscal Year: 2013
    ..and has been detected in 80-95% of pancreatic cancers;and inactivation of p16/Ink4a/Arf and p53 tumor suppressor genes can be identified approximately 50-75% of pancreas cancers...
  52. MOLECULAR GENETICS OF NUCLEOLAR DOMINANCE
    CRAIG STUART PIKAARD; Fiscal Year: 2012
    ..monoallelic expression, for genes that are subjected to developmentally controlled silencing, or for tumor suppressor genes that become silenced in numerous forms of cancer...
  53. UNIVERSITY OF TEXAS SPORE IN LUNG CANCER
    John D Minna; Fiscal Year: 2013
    ..We have invested in several major translational research themes: identification of key lung cancer tumor suppressor genes and their development as novel therapeutics;identification of persons with an increased inherited and/or ..
  54. Chemoprevention of tobacco carcinogen-induced bladder cancer
    Harikrishna Nakshatri; Fiscal Year: 2011
    ..activation of specific oncogenes and growth factors/chemokines such as CXCL-1 and/or inactivation of tumor suppressor genes (p53, retinoblastoma, BIM, p21, RASSF1A, RUNX3, and p16INK4) through mutations or epigenetic mechanisms...
  55. Molecular Genetics of Inherited Neurological Diseases
    XANDRA OWENS BREAKEFIELD; Fiscal Year: 2012
    ..signaling pathways leading to abnormal neural cell development and growth due to loss of function of tumor suppressor genes. The focus of the proposed studies is on understanding genetic and cellular factors contributing to ..
  56. Early Infant Feeding and Epigenetic Modification in Tumor Suppressor Genes
    Anne Merewood; Fiscal Year: 2010
    ..Goals: 1) To assess the effect of early feeding on aberrant methylation of 40 tumor suppressor genes in 100 infants (50 exclusively breastfed infants, and 50 exclusively formula fed infants) at 4 months...
  57. Epigenetic Reprogramming by the Human Papillomavirus E7 Oncoprotein
    MARGARET ERIN MCLAUGHLIN-DRUBIN; Fiscal Year: 2012
    ..been viewed as a result of mutations that lead to the activation of oncogenes and/or the inactivation of tumor suppressor genes. However, since the initial report in 1983 describing an altered DNA methylation pattern in cancer, it has ..
  58. Condensin II/RBF
    Nicholas J Dyson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The retinoblastoma susceptibility gene (RB1) was one of the first tumor suppressor genes to be discovered and it has long served as prototype for this group of cancer-associated genes...
  59. Integrative genomic analysis in hepatocellular carcinoma
    Josep M Llovet; Fiscal Year: 2011
    ..the gene expression profiles and the somatic genetic alterations of HCC will enable the identification of tumor suppressor genes or oncogenes involved in the pathogenesis of the disease, and will provide markers of early detection and ..
  60. Replication Licensing in Genome Stability, Cancer and Aging
    Steven C Pruitt; Fiscal Year: 2013
    ..damage in the resulting tumors is in the form of short deletions that markedly facilitate identification o tumor suppressor genes. Further, these studies have shown that some strains of mice differ in their ability to manage the ..
  61. Re-expression of Aberrantly Silenced Genes Induced by Polyamine Analogues
    Robert A Casero; Fiscal Year: 2013
    ..Aberrant epigenetic silencing of tumor suppressor genes is critically important in the initiation and progression of cancer...
  62. DNA/RNA G-Quadruplexes: Structures, Transitions and Recognition
    Dinshaw J Patel; Fiscal Year: 2013
    ....
  63. Suppression of glioma invasion by a bicistronic constuct
    JASTI RAO; Fiscal Year: 2007
    ..A more effective therapy for these gliomas is to restore specific tumor suppressor genes and to downregulate genes that are overexpressed because such treatment is directed against the basic ..
  64. Comprehensive Mutational Analysis of the Cancer Genome
    Dennis Ballinger; Fiscal Year: 2004
    ..However, many of the key tumor suppressor genes and oncogenes responsible for cancer initiation and progression remain to be identified...
  65. Neuroblastoma Tumor Suppressor Genes in Zebrafish
    A Look; Fiscal Year: 2007
    ..genetic screening in the zebrafish affords an unparalleled opportunity to discover previously elusive tumor suppressor genes whose alteration leads to disruption of the developing peripheral sympathetic nervous system (PSNS) and ..
  66. Functional analysis of the CYLD tumor suppressor
    JULIDE CELEBI; Fiscal Year: 2009
    ..Mutations leading to gain of function of proto-oncogenes or loss of function of tumor suppressor genes result in tumor development...
  67. CELLULAR PROCESSING OF DAMAGED DNA--ROLE IN ONCOGENESIS
    Philip Hanawalt; Fiscal Year: 2000
    ..in genomic DNA occur at specific sites and can lead to activation of protooncogenes or inactivation of tumor suppressor genes through mutation, recombination, gene amplification, translocation, or other chromosomal abnormalities...
  68. ISOLATION OF A SECOND WILMS TUMOR SUPPRESSOR GENE
    Bernard Weissman; Fiscal Year: 2001
    DESCRIPTION: (adapted from the investigator's abstract) The identification of human tumor suppressor genes has led to new insights into the mechanisms of human cancer development...
  69. DIFFERENTIALLY EXPRESSED GENES IN PRIMARY BREAST CANCER
    ARTHUR PARDEE; Fiscal Year: 1999
    In the initial grant, our aim was to select candidate tumor suppressor genes by their loss of expression in mammary carcinomas compared with well matched normal mammary epithelial cells using differential display...
  70. ERROR CORRECTION IN DNA SYNTHESIS--A BIOCHEMICAL STUDY
    MYRON GOODMAN; Fiscal Year: 2009
    ..Activation of oncogenes and inactivation of tumor suppressor genes leading to cancer can result from single base changes in DNA...
  71. TUMOR SUPPRESSOR GENES IN HUMAN THYROID NEOPLASMS
    James Fagin; Fiscal Year: 1990
    ..Many of these putative tumor suppressor genes are believed to act in a recessive manner, since both copies must be lost or inactivated in order for the ..
  72. CONFERENCE ON GENOMIC INSTABILITY AND DYSREGULATION
    Charles Fox; Fiscal Year: 1991
    ..can increase the frequency of both genetic and epigenetic lesions including those in proto- oncogenes and tumor suppressor genes. The molecular mechanisms controlling genomic stability and fidelity of DNA synthesis and DNA repair are ..