multifactorial inheritance

Summary

Summary: A phenotypic outcome (physical characteristic or disease predisposition) that is determined by more than one gene. Polygenic refers to those determined by many genes, while oligogenic refers to those determined by a few genes.

Top Publications

  1. ncbi Finding genes that underlie complex traits
    Anne M Glazier
    Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College Faculty of Medicine, DuCane Road, London W12 0NN, UK
    Science 298:2345-9. 2002
  2. pmc Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
    Eli A Stahl
    Division of Rheumatology Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 44:483-9. 2012
  3. ncbi Genome-wide association studies for common diseases and complex traits
    Joel N Hirschhorn
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
    Nat Rev Genet 6:95-108. 2005
  4. pmc The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation
    Jonathan K Pritchard
    Department of Human Genetics, The University of Chicago, Room 507, 929 E 58th St, Chicago, IL 60637, USA
    Curr Biol 20:R208-15. 2010
  5. ncbi Predictive testing for complex diseases using multiple genes: fact or fiction?
    A Cecile J W Janssens
    Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Genet Med 8:395-400. 2006
  6. ncbi Common disorders are quantitative traits
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Nat Rev Genet 10:872-8. 2009
  7. ncbi Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses
    P M Visscher
    Queensland Institute of Medical Research, Herston, Queensland, Australia
    Mol Psychiatry 17:474-85. 2012
  8. ncbi Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions
    Lance W Hahn
    Program in Human Genetics and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Bioinformatics 19:376-82. 2003
  9. pmc Impacts of both reference population size and inclusion of a residual polygenic effect on the accuracy of genomic prediction
    Zengting Liu
    Christian Albert University, Institute of Animal Breeding and Husbandry, 24908 Kiel, Germany
    Genet Sel Evol 43:19. 2011
  10. ncbi Polygenes, risk prediction, and targeted prevention of breast cancer
    Paul D P Pharoah
    Department of Oncology, University of Cambridge, United Kingdom
    N Engl J Med 358:2796-803. 2008

Research Grants

  1. ORAL-FACIAL CLEFTS IN CHINA
    Michael Melnick; Fiscal Year: 1990
  2. BAYLOR BIRCWH PROGRAM
    Joe Simpson; Fiscal Year: 2004
  3. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
  4. Linkage Disequilibrium Methods For Complex Trait Mapping
    Jonathan Pritchard; Fiscal Year: 2007
  5. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
  6. Molecular Genetics of Cadmium Toxicity
    Daniel W Nebert; Fiscal Year: 2010
  7. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
  8. LINKAGE ANALYSIS METHODS IN SCHIZOPHRENIA
    Jurg Ott; Fiscal Year: 2008
  9. Association of inflammatory genes and prostate cancer
    Jianfeng Xu; Fiscal Year: 2008
  10. Impact of Smoking Cessation on Sleep
    Gary Swan; Fiscal Year: 2008

Detail Information

Publications215 found, 100 shown here

  1. ncbi Finding genes that underlie complex traits
    Anne M Glazier
    Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College Faculty of Medicine, DuCane Road, London W12 0NN, UK
    Science 298:2345-9. 2002
    ..These proof-of-concept studies demonstrate the insights that can be expected from the accelerating pace of gene discovery in this field...
  2. pmc Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
    Eli A Stahl
    Division of Rheumatology Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Nat Genet 44:483-9. 2012
    ..These analyses suggest that GWAS will continue to be highly productive for the discovery of additional susceptibility loci for common diseases...
  3. ncbi Genome-wide association studies for common diseases and complex traits
    Joel N Hirschhorn
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
    Nat Rev Genet 6:95-108. 2005
    ..Genome-wide association studies will soon become possible, and could open new frontiers in our understanding and treatment of disease. However, the execution and analysis of such studies will require great care...
  4. pmc The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation
    Jonathan K Pritchard
    Department of Human Genetics, The University of Chicago, Room 507, 929 E 58th St, Chicago, IL 60637, USA
    Curr Biol 20:R208-15. 2010
    ..We close by discussing some of the likely opportunities for progress in the field...
  5. ncbi Predictive testing for complex diseases using multiple genes: fact or fiction?
    A Cecile J W Janssens
    Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Genet Med 8:395-400. 2006
    ..There is ongoing debate about whether testing low-risk genes at multiple loci will be useful in clinical care and public health. We investigated the usefulness of multiple genetic testing using simulated data...
  6. ncbi Common disorders are quantitative traits
    Robert Plomin
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London SE5 8AF, UK
    Nat Rev Genet 10:872-8. 2009
    ..Research that focuses on quantitative traits - including the low and high ends of normal distributions - could have far-reaching implications for the diagnosis, treatment and prevention of the problematic extremes of these traits...
  7. ncbi Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses
    P M Visscher
    Queensland Institute of Medical Research, Herston, Queensland, Australia
    Mol Psychiatry 17:474-85. 2012
    ..We conclude that larger experimental sample sizes are essential to further our understanding of the biology underlying psychiatric disorders...
  8. ncbi Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions
    Lance W Hahn
    Program in Human Genetics and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Bioinformatics 19:376-82. 2003
    ..In this paper, we describe the MDR approach and an MDR software package...
  9. pmc Impacts of both reference population size and inclusion of a residual polygenic effect on the accuracy of genomic prediction
    Zengting Liu
    Christian Albert University, Institute of Animal Breeding and Husbandry, 24908 Kiel, Germany
    Genet Sel Evol 43:19. 2011
    ..The purpose of this work was to study the impact of both the size of genomic reference populations and the inclusion of a residual polygenic effect on dairy cattle genetic evaluations enhanced with genomic information...
  10. ncbi Polygenes, risk prediction, and targeted prevention of breast cancer
    Paul D P Pharoah
    Department of Oncology, University of Cambridge, United Kingdom
    N Engl J Med 358:2796-803. 2008
    ..New developments in the search for susceptibility alleles in complex disorders provide support for the possibility of a polygenic approach to the prevention and treatment of common diseases...
  11. ncbi The modular nature of genetic diseases
    M Oti
    Centre for Molecular and Biomolecular Informatics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands
    Clin Genet 71:1-11. 2007
    ....
  12. pmc Polygenic variation maintained by balancing selection: pleiotropy, sex-dependent allelic effects and G x E interactions
    Michael Turelli
    Section of Evolution and Ecology and Center for Population Biology, University of California, Davis 95616, USA
    Genetics 166:1053-79. 2004
    ..We present numerical results that support our analytical approximations and discuss our results in connection to relevant data and alternative variance-maintaining mechanisms...
  13. pmc Polygenic dissection of the bipolar phenotype
    M L Hamshere
    MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, UK
    Br J Psychiatry 198:284-8. 2011
    ..Recent data provide strong support for a substantial common polygenic contribution (i.e. many alleles each of small effect) to genetic susceptibility for schizophrenia and overlapping susceptibility for bipolar disorder...
  14. pmc Evidence for polygenic susceptibility to multiple sclerosis--the shape of things to come
    William S Bush
    Vanderbilt University, USA
    Am J Hum Genet 86:621-5. 2010
    ....
  15. ncbi Adaptation - not by sweeps alone
    Jonathan K Pritchard
    Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Illinois 60615, USA
    Nat Rev Genet 11:665-7. 2010
    ..Jonathan Pritchard and Anna Di Rienzo argue that many adaptive events in natural populations may occur by polygenic adaptation, which would largely go undetected by conventional methods for detecting selection...
  16. pmc Recent methods for polygenic analysis of genome-wide data implicate an important effect of common variants on cardiovascular disease risk
    Matthew A Simonson
    Department of Psychology, University of Colorado Boulder, USA
    BMC Med Genet 12:146. 2011
    ....
  17. pmc The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRI
    H C Whalley
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Transl Psychiatry 2:e130. 2012
    ..The findings suggest that this novel polygenic approach to examine brain-imaging data may be a useful means of identifying genetically mediated traits mechanistically linked to the aetiology of BD...
  18. pmc The genetic dissection of complex traits in a founder population
    C Ober
    Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
    Am J Hum Genet 69:1068-79. 2001
    ..However, even in this young founder population that has extensive linkage disequilibrium, map densities <<5 cM may be required to detect all major QTLs...
  19. pmc Genetic and environmental effects on complex traits in mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    Genetics 174:959-84. 2006
    ..Our results indicate that assays of gene function using mouse models should take into account interactions between gene and environment...
  20. ncbi Candidate-gene approaches for studying complex genetic traits: practical considerations
    Holly K Tabor
    Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Nat Rev Genet 3:391-7. 2002
    ..We believe that these criticisms can be usefully countered with an appeal to the principles of epidemiological investigation...
  21. pmc Relaxed significance criteria for linkage analysis
    Lin Chen
    Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA
    Genetics 173:2371-81. 2006
    ..A generalized version of the GWER is proposed, called GWERk, that allows one to provide a more liberal balance between true positives and false positives at no additional cost in computation or assumptions...
  22. pmc Heritability of cardiovascular and personality traits in 6,148 Sardinians
    Giuseppe Pilia
    Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Ospedale Microcitemico, Cagliari, Italy
    PLoS Genet 2:e132. 2006
    ..Evidence for heterogeneity by age and sex suggests that models allowing for these differences will be important in mapping quantitative traits...
  23. ncbi Major gene and multifactorial inheritance of mandibular prognathism
    Ricardo Machado Cruz
    Departament of Genetics and Morphology, University of Brasilia, Brasilia, DF, Brazil
    Am J Med Genet A 146:71-7. 2008
    ..316. We conclude that there is a major gene that influences the expression of mandibular prognathism with clear signs of Mendelian inheritance and a multifactorial component...
  24. pmc Polygenic modeling of genome-wide association studies: an application to prostate and breast cancer
    John S Witte
    Institute for Human Genetics, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA
    OMICS 15:393-8. 2011
    ..This supports the further development and application of polygenic models to genomic data...
  25. pmc Polygenic and directional regulatory evolution across pathways in Saccharomyces
    James H Bullard
    Division of Biostatistics, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 107:5058-63. 2010
    ..We suggest that pathway analyses, including our test for directional regulatory evolution, will prove to be a relevant and powerful strategy in many evolutionary genomic applications...
  26. pmc Genomewide scans of complex human diseases: true linkage is hard to find
    J Altmuller
    Institute of Epidemiology, GSF corrected National Research Center for Environment and Health, Neuherberg, Germany
    Am J Hum Genet 69:936-50. 2001
    ..Positional cloning based on whole-genome screens in complex human disease has proved more difficult than originally had been envisioned; detection of linkage and positional cloning of specific disease-susceptibility loci remains elusive...
  27. ncbi Domestic-animal genomics: deciphering the genetics of complex traits
    Leif Andersson
    Department of Medical Biochemistry and Microbiology, Uppsala University, Box 597, SE 751 24 Uppsala, Sweden
    Nat Rev Genet 5:202-12. 2004
  28. ncbi Environmental and genetic risk factors in obesity
    Johannes Hebebrand
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Virchowstr, 174, D 45147 Essen, Germany
    Child Adolesc Psychiatr Clin N Am 18:83-94. 2009
    ..Important factors are socioeconomic status and television consumption. The authors conclude by briefly assessing implications for treatment and prevention of childhood obesity...
  29. ncbi Polygenic inherited predisposition to breast cancer
    B A J Ponder
    Department of Oncology and Public Health and Cancer Research UK Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, UK
    Cold Spring Harb Symp Quant Biol 70:35-41. 2005
    ..A key unanswered question is the "genetic architecture" of predisposition-that is, strong or weak alleles, common or rare. We describe a genome-wide scan designed to provide a first-pass answer to this question...
  30. ncbi Accuracy of breeding values when using and ignoring the polygenic effect in genomic breeding value estimation with a marker density of one SNP per cM
    M P L Calus
    Animal Breeding and Genomics Centre, Animal Sciences Group, Wageningen University and Research Centre, Lelystad, The Netherlands
    J Anim Breed Genet 124:362-8. 2007
    ..The haplotype variance was less underestimated when more animals were added in the reference dataset...
  31. pmc A genomic screen of autism: evidence for a multilocus etiology
    N Risch
    Department of Genetics, M322, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
    Am J Hum Genet 65:493-507. 1999
    ..Our results suggest that positional cloning of susceptibility loci by linkage analysis may be a formidable task and that other approaches may be necessary...
  32. pmc A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia
    Robert A Hegele
    Vascular Biology Research Group, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
    Hum Mol Genet 18:4189-94. 2009
    ....
  33. ncbi Beyond Mendel: an evolving view of human genetic disease transmission
    Jose L Badano
    Institute of Genetic Medicine, Johns Hopkins University, 2 127 Jefferson Street Building, Baltimore, Maryland 21287, USA
    Nat Rev Genet 3:779-89. 2002
    ....
  34. pmc Narrowing the boundaries of the genetic architecture of schizophrenia
    Naomi R Wray
    Genetic Epidemiology and Queensland Statistical Genetics, Queensland Institute of Medical Research, 330 Herston Road, Brisbane 4029, Australia
    Schizophr Bull 36:14-23. 2010
    ..The first generation of studies have generated hypotheses that should be testable in the near future and will further narrow the boundaries on genetic architectures that are consistent with empirical data...
  35. pmc A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11
    B E Aouizerat
    Departments of 1Microbiology and Molecular Genetics, Medicine, Human Genetics, Molecular Biology Institute, University of California, UCLA School of Medicine Los Angeles, CA 90095 1679, USA
    Am J Hum Genet 65:397-412. 1999
    ..This region does not contain any strong candidate genes. These results provide evidence for a candidate chromosomal region for FCHL and support the concept that FCHL is complex and heterogeneous...
  36. pmc Empirically derived phenotypic subgroups - qualitative and quantitative trait analyses
    Marsha A Wilcox
    Genetics Program, Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
    BMC Genet 4:S15. 2003
    ....
  37. ncbi Polygenic determinants of severe hypertriglyceridemia
    Jian Wang
    Vascular Biology Research Group 2 Clinical Trials Group, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Hum Mol Genet 17:2894-9. 2008
    ..At the extremes of a quantitative trait, such as severe HTG, are found the cumulative contributions of both multiple rare alleles with large genetic effects and common alleles with small effects...
  38. pmc Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, 27157, USA
    Am J Hum Genet 71:646-50. 2002
    ..06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LOD = 1.86, D12S375). Our results provide evidence that a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits...
  39. ncbi A polygenic basis for late-onset disease
    Alan Wright
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, EH4 2XU, Edinburgh, UK
    Trends Genet 19:97-106. 2003
    ..The origin and nature of this variation suggests that current strategies are poorly suited to identifying genes involved in many complex diseases...
  40. pmc Genetic Analysis Workshop 13: simulated longitudinal data on families for a system of oligogenic traits
    E Warwick Daw
    Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    BMC Genet 4:S3. 2003
    ....
  41. pmc Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism
    D Q Ma
    Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Hum Genet 77:377-88. 2005
    ..These results support the hypothesis that GABA receptor subunit genes are involved in autism, most likely via complex gene-gene interactions...
  42. ncbi Polygenic obesity in humans
    Anke Hinney
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    Obes Facts 1:35-42. 2008
    ..In the first GWA for extreme early onset obesity we substantiated that variation in FTO strongly contributes to early onset obesity...
  43. pmc Estimating polygenic effects using markers of the entire genome
    Shizhong Xu
    Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    Genetics 163:789-801. 2003
    ..Similar results were found from simulated data sets of F(2) and backcross (BC) families...
  44. ncbi The genome-wide association study--a new era for common polygenic disorders
    Robert Roberts
    The Ruddy Canadian Cardiovascular Genetics Centre, Ottawa, Ontario, Canada
    J Cardiovasc Transl Res 3:173-82. 2010
    ..This will require a new approach involving several disciplines, namely, bioinformatics, high-throughput cell expression, and animal models...
  45. ncbi Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a model
    Nicola S Fearnhead
    Cancer Research U K Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, Oxford, UK
    Cell Cycle 4:521-5. 2005
    ..Recent evidence suggests that a quarter of patients with multiple adenomatous polyps are due to rare but functionally important variants in just five genes...
  46. pmc Persistence of accuracy of genome-wide breeding values over generations when including a polygenic effect
    Trygve R Solberg
    Norwegian University of Life Sciences, Department of Animal and Aquacultural Sciences, PO Box 5003, N 1432 As, Norway
    Genet Sel Evol 41:53. 2009
    ....
  47. ncbi Implications of multifactorial inheritance for identification of genetic mechanisms in major psychiatric disorders
    John I Nurnberger
    Psychiatr Genet 12:121-6. 2002
  48. ncbi The effect of reduction in cross-validation intervals on the performance of multifactor dimensionality reduction
    Alison A Motsinger
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0700, USA
    Genet Epidemiol 30:546-55. 2006
    ..The validity of this reduction was confirmed with data from an Alzheimer's disease (AD) study...
  49. pmc Imputation methods for missing data for polygenic models
    Brooke Fridley
    Department of Statistics, Iowa State University, Ames, Iowa, USA
    BMC Genet 4:S42. 2003
    ..Thus, we recommend the Gibbs sampler for imputation purposes because of the ease with which it can be extended to more complicated models, the consistency of the results, and the accountability of the variation due to imputation...
  50. ncbi Sib-pairs in multifactorial disorders: the sib-similarity problem
    J H Edwards
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK
    Clin Genet 63:1-9. 2003
    ..Possible reasons for this limited success and the many suggestive false positives are considered...
  51. pmc Longitudinal variance-components analysis of the Framingham Heart Study data
    Stuart Macgregor
    Biostatistics and Bioinformatics Unit, University of Wales College of Medicine, Heath Hospital, Cardiff, United Kingdom
    BMC Genet 4:S22. 2003
    ..The traits of interest were BMI, HDLC, total cholesterol, and height. The longitudinal method allowed the characterization of the change in QTL effects with aging. A QTL affecting BMI was shown to act mainly at early ages...
  52. ncbi Whole-genome patterns of common DNA variation in three human populations
    David A Hinds
    Perlegen Sciences Inc, 2021 Stierlin Court, Mountain View, CA 94043, USA
    Science 307:1072-9. 2005
    ..Our data provide a tool for exploring many questions that remain regarding the causal role of common human DNA variation in complex human traits and for investigating the nature of genetic variation within and between human populations...
  53. ncbi Adult-onset Alopecia areata is a complex polygenic trait in the C3H/HeJ mouse model
    John P Sundberg
    The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
    J Invest Dermatol 123:294-7. 2004
    ..These results indicate the necessity of integrating both gene association and genome-wide linkage studies in both mice and humans to understand the complex nature of these and other polygenic diseases...
  54. ncbi Gene-environment interactions in complex diseases: genetic models and methods for QTL mapping in multiple half-sib populations
    Haja N Kadarmideen
    Statistical Animal Genetics Group, Institute of Animal Science, Swiss Federal Institute of Technology, ETH Zentrum UNS D7, Universitaetstrasse 65, Zurich 8092, Switzerland
    Genet Res 88:119-31. 2006
    ..Top-down model selection is proposed in which a full test for QEI is conducted first and then the model is subsequently simplified. Methods and results will be applicable to human, plant and animal QTL mapping experiments...
  55. pmc Within-family marker-assisted selection for aquaculture species
    Anna K Sonesson
    AKVAFORSK Institute of Aquaculture Research Ltd, P O Box 5010, 1432 As, Norway
    Genet Sel Evol 39:301-17. 2007
    ..There was no significant difference in polygenic genetic gain between MAS and NONMAS for most schemes. The rates of inbreeding were lower for MAS than NON-MAS schemes, because fewer full-sibs were selected by MAS...
  56. ncbi Bayesian inference on major loci in related multigeneration selection lines of laying hens
    C Hagger
    Breeding Biology Group, Institute of Animal Science, Swiss Federal Institute of Technology, ETH Zentrum, CH 8092 Zurich, Switzerland
    Poult Sci 83:1932-9. 2004
    ..The detection of a major locus with relatively modest effect confirmed that this type of analysis with data from selected lines was indeed powerful...
  57. ncbi [New strategies in schizophrenia: impact of endophentotypes]
    Carolin Opgen-Rhein
    Klinik und Hochschulambulanz für Psychiatrie und Psychotherapie, Charite Universitatsmedizin Berlin
    Psychiatr Prax 31:S194-9. 2004
    ....
  58. ncbi Genetics. Harvesting medical information from the human family tree
    David Altshuler
    Broad Institute of Harvard and Massachusetts Institute of Technology, and Massachusetts General Hospital, Boston, MA 02114, USA
    Science 307:1052-3. 2005
  59. ncbi Epistasis and balanced polymorphism influencing complex trait variation
    Juergen Kroymann
    Max Planck Institute for Chemical Ecology, Department of Genetics and Evolution, Hans Knoell Str 8, D 07745 Jena, Germany
    Nature 435:95-8. 2005
    ..If this region typifies many complex trait loci, then non-neutral epistatic polymorphism may be an important contributor to genetic variation in complex traits...
  60. pmc Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarrays
    L M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Genes Brain Behav 7:435-46. 2008
    ..11 (P < 0.00000003) with g. This shows that future SNP sets that will incorporate many more SNPs could be useful for predicting genetic risk and for investigating functional systems of effects from genes to brain to behavior...
  61. ncbi Genetics of metabolic syndrome: is there a role for phenomics?
    Tisha Joy
    Robarts Research Institute, 406 100 Perth Drive, London, Ontario, N6A 5K8, Canada
    Curr Atheroscler Rep 10:201-8. 2008
    ....
  62. ncbi Common and rare alleles as causes of complex phenotypes
    Constantin Polychronakos
    Montreal Children s Hospital, 2300 Tupper Street, Suite C244, Montreal, Quebec, H3H 1P3, Canada
    Curr Atheroscler Rep 10:194-200. 2008
    ..Because the models are not mutually exclusive, the question should be not which model is correct, but rather what is the relative contribution of each, which is something that may vary dramatically among traits...
  63. pmc Candidate genes for obesity revealed from a C57BL/6J x 129S1/SvImJ intercross
    Z Su
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Int J Obes (Lond) 32:1180-9. 2008
    ..To identify the genes controlling body fat, we carried out a quantitative trait locus (QTL) analysis using C57BL/6J (B6) and 129S1/SvImJ (129) mice, which differ in obesity susceptibility after consuming an atherogenic diet...
  64. ncbi Two-stage designs to identify the effects of SNP combinations on complex diseases
    Guolian Kang
    Key Laboratory of Systems and Control, Institute of Systems Science, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, 100080, China
    J Hum Genet 53:739-46. 2008
    ..Using synergistic blocks, we can reduce the dimensionality in a multi-locus association analysis, and evaluate the sizes of interactive effects among multiple disease genes on complex phenotypes...
  65. pmc Mapping quantitative trait loci for longitudinal traits in line crosses
    Runqing Yang
    School of Agriculture and Biology, Shanghai Jiaotong University, People s Republic of China
    Genetics 173:2339-56. 2006
    ..The method is verified with simulated data and demonstrated with experimental data from a pseudobackcross family of Populus (poplar) trees...
  66. ncbi Segregation analysis of a complex quantitative trait: approaches for identifying influential data points
    Robert P Igo
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    Hum Hered 61:80-6. 2006
    ..Here we use an oligogenic Bayesian Markov chain Monte Carlo method for SA (OSA) to verify results from a single-locus likelihood-based CSA for data on a quantitative measure of reading ability...
  67. ncbi A proposal concept of a polygene network in systemic vasculitis: lessons from MRL mouse models
    Masato Nose
    Department of Pathogenomics, Ehime University Graduate School of Medicine, Ehime, Japan
    Allergol Int 56:79-86. 2007
    ..This is designated as the polygene network in systemic vasculitis...
  68. pmc The efficiency of mapping of quantitative trait loci using cofactor analysis in half-sib design
    Goutam Sahana
    Department of Genetics and Biotechnology, Danish Institute of Agricultural Sciences, Research Centre Foulum, Tjele, 8830, Denmark
    Genet Sel Evol 38:167-82. 2006
    ..Our study shows that cofactor analysis increased the number of false positives in all scenarios with low heritability and the increase was up to 50% in low power experiments and with lower thresholds for cofactors...
  69. ncbi Resolving the IQ paradox: heterosis as a cause of the Flynn effect and other trends
    Michael A Mingroni
    Psychol Rev 114:806-29. 2007
    ..The goal of the modeling is to develop a quantitatively rigorous method for estimating the potential contribution of heterosis in the Flynn effect, as well as trends observed in other heritable traits and conditions...
  70. ncbi Discrete polymorphisms due to disruptive selection on a continuous trait--I: the one-locus case
    Carlo Matessi
    Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, via Abbiategrasso 207, IT 27100 Pavia, Italy
    Theor Popul Biol 69:283-95. 2006
    ..In this case a population at the long-term equilibrium might even be genetically monomorphic, with the phenotypic dimorphism resulting from purely random individual variation...
  71. ncbi Cardiovascular genomics
    Marc S Sabatine
    Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 113:e450-5. 2006
  72. pmc A molecular selection index method based on eigenanalysis
    J Jesús Cerón-Rojas
    Colegio de Postgraduados, Carretera México Texcoco, Montecillo, Estado de Mexico, Mexico
    Genetics 180:547-57. 2008
    ....
  73. ncbi [Multifactorial diseases: a nightmare for the geneticist]
    Josue Feingold
    INSERM U 393, Hopital Necker Enfants Malades, 149, rue de Sevres, 75015 Paris, France
    Med Sci (Paris) 21:927-33. 2005
    ..Most of the results have not been replicated, identifying susceptibility genes is proving much more difficult than most geneticists imagined 20 years ago. The main reason for this irreproducibility is genetic heterogeneity...
  74. ncbi Bioinformatics and approaches to identifying polygenic susceptibility traits
    Bruce S Weir
    Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
    Ann Periodontol 7:1-7. 2002
    ..Current thinking tends to focus on relatively conserved "haplotype blocks" instead of single genetic markers, although there is no consensus on the utility of this emphasis...
  75. ncbi Genetic aspects of hypertension and metabolic disease in the obstructive sleep apnoea-hypopnoea syndrome
    Renata L Riha
    Department of Sleep Medicine, Royal Infirmary Edinburgh, 51 Little France Crescent, Little France, Edinburgh, UK
    Sleep Med Rev 12:49-63. 2008
    ..This review focuses on genetic factors, which may be responsible for the expression of cardiovascular disease and metabolic syndrome in the context of OSAHS...
  76. ncbi MCMC-based linkage analysis for complex traits on general pedigrees: multipoint analysis with a two-locus model and a polygenic component
    Yun Ju Sung
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195 7720, USA
    Genet Epidemiol 31:103-14. 2007
    ..Our examples illustrate the advantage of parametric linkage analysis with two QTLs, which provides higher power for linkage detection and better localization than use of simpler models...
  77. pmc A study on the minimum number of loci required for genetic evaluation using a finite locus model
    Liviu R Totir
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Genet Sel Evol 36:395-414. 2004
    ..For highly heritable traits, models with up to six loci were needed to match the evaluations obtained by BLP...
  78. ncbi Detection of quantitative trait loci affecting caffeine metabolism by interval mapping in a genome-wide scan of C3H/HeJ x APN F(2) mice
    W L Casley
    Research Division, Therapeutic Products Programme, Health Canada
    Drug Metab Dispos 27:1375-80. 1999
    ..This study demonstrates the utility of quantitative genetics in the analysis of polygenic drug metabolism...
  79. ncbi Novel approaches to identify low-penetrance cancer susceptibility genes using mouse models
    John P de Koning
    UCSF Comprehensive Cancer Center and Cancer Research Institute, Department of Biochemistry and Biophysics, University of California San Francisco, 2340 Sutter Street, San Francisco, CA 94115, USA
    Recent Results Cancer Res 163:19-27; discussion 264-6. 2003
    ..Novel approaches that might accelerate the identification of these low-penetrance cancer susceptibility genes by using mouse models will be discussed...
  80. pmc Loci on chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains
    Danielle R Reed
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 14:302-13. 2003
    ..These results reinforce the concept that obesity is a complex trait. Genetic loci and their interactions, in conjunction with sex, age, and diet, determine body size and adiposity in mice...
  81. ncbi Early onset albuminuria in Dahl rats is a polygenetic trait that is independent from salt loading
    Ali Poyan Mehr
    Institute of Clinical Pharmacology and Toxicology, Universitätsklinikum Benjamin Franklin Hospital, Freie Universitat Berlin, Germany
    Physiol Genomics 14:209-16. 2003
    ..Thus early onset albuminuria in the SS rat is under polygenetic influence and independent from salt loading...
  82. pmc The complexity of complex diseases
    P Michael Conneally
    Department of Medical and Molecular Genetics, Indiana University, Indianapolis, 46202 5251, USA
    Am J Hum Genet 72:229-32. 2003
  83. pmc A further look at quantitative trait loci affecting growth and fatness in a cross between Meishan and Large White pig populations
    Raquel Quintanilla
    Station de Génétique Quantitative et Appliquée, Institut National de la Recherche Agronomique, 78352 Jouy en Josas Cedex, France
    Genet Sel Evol 34:193-210. 2002
    ..The second QTL had a favourable LW allele and was located in the proximal extremity of the q arm of chromosome 1. Suggestive genomic imprinting was found in the distal region of chromosome 9 affecting growth during the fattening period...
  84. ncbi Power of a simplified multivariate test for genetic linkage
    O Y Gorlova
    Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Ann Hum Genet 66:407-17. 2002
    ..The method identified meaningful combinations of traits that showed significant linkage on chromosome 2 and suggestive linkage to regions on chromosomes 16 and 17...
  85. ncbi Backward Haplotype Transmission Association (BHTA) algorithm - a fast multiple-marker screening method
    Shaw Hwa Lo
    Department of Statistics, Columbia University, New York, NY 10027, USA
    Hum Hered 53:197-215. 2002
    ..Detailed theoretical justifications are also included, which explains why the algorithm is likely to select the 'correct' markers...
  86. ncbi A unified approach to joint modeling of multiple quantitative and qualitative traits in gene mapping
    Jukka Corander
    Rolf Nevanlinna Institute, University of Helsinki, 4, Finland
    J Theor Biol 218:435-46. 2002
    ..Outline of the possible implementation of the Bayesian method is described using the general reversible-jump Markov chain Monte Carlo algorithm. Some future challenges and extensions are also discussed...
  87. pmc Voluntary ethanol consumption by mice: genome-wide analysis of quantitative trait loci and their interactions in a C57BL/6ByJ x 129P3/J F2 intercross
    Alexander A Bachmanov
    Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
    Genome Res 12:1257-68. 2002
    ..However, there were a few modifiers of the primary linkages and a number of interactions among unlinked loci. This demonstrates a significant role of the genetic background in the variation of ethanol consumption...
  88. ncbi Mapping quantitative effects of oligogenes by allelic association
    W Zhang
    Human Genetics Division, Southampton General Hospital, UK
    Ann Hum Genet 66:211-21. 2002
    ..However, rigorous confirmation requires that the causal SNPs be identified. Both Malecot and parametric analysis appear to have high power by comparison with alternative methods for localizing oligogenes and their causal polymorphisms...
  89. ncbi Toward positional cloning with SNPs
    Newton E Morton
    Human Genetics, Southampton General Hospital, UK
    Curr Opin Mol Ther 4:259-64. 2002
    ....
  90. pmc Optimal selection on two quantitative trait loci with linkage
    Jack C M Dekkers
    Department of Animal Science, 225 Kildee Hall, Iowa State University Ames, IA 50011, USA
    Genet Sel Evol 34:171-92. 2002
    ..These results demonstrate the ability of optimal selection to capitalize on information on the complex genetic basis of quantitative traits that is forthcoming...
  91. ncbi A novel approach to search for identity by descent in small samples of patients and controls from the same mendelian breeding unit: a pilot study on myopia
    S Heath
    Department of Human Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
    Hum Hered 52:183-90. 2001
    ..The iterative application of our strategy in separate MBUs is expected to become the method of choice to evaluate the ever-growing number of reported associations between candidate genes and multifactorial traits and diseases...
  92. ncbi Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses
    R J Roper
    Department of Veterinary Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA
    Genes Immun 2:388-97. 2001
    ..Interestingly, some alleles contributing to susceptibility to Lyme arthritis were derived from C57BL/6N and BALB/cAnN mice, showing that disease-resistant strains harbor susceptibility alleles...
  93. ncbi Evidence for further breast cancer susceptibility genes in addition to BRCA1 and BRCA2 in a population-based study
    A C Antoniou
    CRC Genetic Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
    Genet Epidemiol 21:1-18. 2001
    ....
  94. ncbi Accuracy of marker-assisted selection with auxiliary traits
    P Narain
    J Biosci 28:569-79. 2003
    ....
  95. ncbi Conditional multipoint linkage analysis using affected sib pairs: an alternative approach
    Yen Feng Chiu
    Division of Biostatistics and Bioinformatics, National Health Research Institutes, Taiwan, R O C
    Genet Epidemiol 26:108-15. 2004
    ..The performance of both approaches is quite comparable showing consistent estimates of the trait locus and key genetic parameters...
  96. pmc Consistency of linkage results across exams and methods in the Framingham Heart Study
    Larry D Atwood
    Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts, USA
    BMC Genet 4:S30. 2003
    ..We compared regression-based linkage to variance components linkage across time for six quantitative traits in the real data...
  97. pmc Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human data
    Simon N Twigger
    Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Genome Res 14:651-60. 2004
    ..Integrating rat physiology with mouse genetics and clinical results from human by using the respective genomes provides a novel route to capitalize on comparative genomics and the strengths of model organism biology...
  98. pmc Evidence for bivariate linkage of obesity and HDL-C levels in the Framingham Heart Study
    Rector Arya
    Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    BMC Genet 4:S52. 2003
    ..Subsequently, we performed bivariate multipoint linkage analysis to detect common loci influencing covariation between these two traits...
  99. ncbi A simulation study concerning the effect of varying the residual phenotypic correlation on the power of bivariate quantitative trait loci linkage analysis
    David M Evans
    Queensland Institute of Medical Research and Joint Genetics Program, University of Queensland, PO Royal Brisbane Hospital, Brisbane 4029, Australia
    Behav Genet 34:135-41. 2004
    ..g., from multivariate structural equation modeling of twin data) or a sound theoretical argument that the QTL and environmental factors induce covariation in opposite directions...
  100. ncbi [Estimating family correlation of quantitative traits using generalized estimating equation]
    Yan Hui Gao
    Department of Epidemiology, College of Public Health, Fudan University, Shanghai 200032, China
    Zhonghua Liu Xing Bing Xue Za Zhi 24:729-33. 2003
    ..To study the method for measuring familial correlations of quantitative trait and analyzing family data set of body height...
  101. pmc Mapping complex traits using Random Forests
    Alexandre Bureau
    Genome Therapeutics Corporation, Waltham, Massachusetts 02453, USA
    BMC Genet 4:S64. 2003
    ..Random Forest was able to identify a few of the major genes influencing the phenotypes, such as baseline HDL and triglycerides, but failed to identify the major genes regulating baseline glucose levels...

Research Grants63

  1. ORAL-FACIAL CLEFTS IN CHINA
    Michael Melnick; Fiscal Year: 1990
    ..effects and utilization of a variety of segregation analyses to test for single major gene inheritance, multifactorial inheritance, mixed inheritance, etc...
  2. BAYLOR BIRCWH PROGRAM
    Joe Simpson; Fiscal Year: 2004
    ..These goals are vital to public health in contributing to the establishment of methods for production of safe, effective, quality herbal extracts for consumer use. ..
  3. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
    ..abstract_text> ..
  4. Linkage Disequilibrium Methods For Complex Trait Mapping
    Jonathan Pritchard; Fiscal Year: 2007
    ..The long term goal of this project is to develop statistical/computational tools and models of LD that can be of practical use to complex trait mapping community, and will contribute to cheaper and more effective studies. ..
  5. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..dissemination of ingested BaP and will be informative in clinical studies in which we would determine which haplotypes of these three human genes might be associated with resistance vs. sensitivity to PAH-induced toxicity and cancer. ..
  6. Molecular Genetics of Cadmium Toxicity
    Daniel W Nebert; Fiscal Year: 2010
    ....
  7. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
    ..S. population. ..
  8. LINKAGE ANALYSIS METHODS IN SCHIZOPHRENIA
    Jurg Ott; Fiscal Year: 2008
    ..Computer programs and methods obtained through this work will be made available to researchers. ..
  9. Association of inflammatory genes and prostate cancer
    Jianfeng Xu; Fiscal Year: 2008
    ..Answers to these questions will significantly improve our knowledge of the role of inflammation in prostate cancer and will guide our efforts in identifying additional prostate cancer genes. ..
  10. Impact of Smoking Cessation on Sleep
    Gary Swan; Fiscal Year: 2008
    ..The results of this project will be particularly important for the development of targeted treatment approaches designed to ameliorate sleep disruption as part of an overall smoking cessation strategy. ..
  11. GENETIC ANALYSIS OF HIRSCHSPRUNG DISEASE
    Aravinda Chakravarti; Fiscal Year: 2008
    ..The long-term objective of this study is to understand the molecular genetic basis of HSCR. More generally, our aim is to develop a paradigm for sequence-based biology in complex, human diseases. [unreadable] [unreadable]..
  12. In silico genome scan with high-throughput addiction related phenotypes in mice
    Edwin van den Oord; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. Pathways to Alcohol Tolerance
    Boris Tabakoff; Fiscal Year: 2006
    ..In all, our studies should provide an excellent foundation for understanding the neuroadaptive processes leading to ethanol tolerance in reference to the anxiolytic action of this drug. ..
  14. The Role of Toll-Like Receptors in NPC
    YIN YAO; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  15. Genetic epidemiology of irritable bowel syndrome (IBS)
    YURI SAITO LOFTUS; Fiscal Year: 2008
    ....
  16. MOLECULAR GENETICS OF HEREDITARY PANCREATITIS
    David Whitcomb; Fiscal Year: 2008
    ..The HP and familial pancreatitis studies are especially important because of the statistical power of family studies and the ability to detect modifier genes in a uniform background of susceptibility factors. ..
  17. Interaction of PTEN and CDKN1B in Pca susceptibility
    Jianfeng Xu; Fiscal Year: 2008
    ..The results from this study are likely to significant advance our knowledge of prostate cancer risk and begin to explore the underlying biological mechanisms for any observed differences. ..
  18. Genome-wide association of common alleles with long-term diabetic complications
    Andrew Paterson; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  19. Inferring Multiple-SNP Disease Association with DNA Resequence Data
    Rasmus Nielsen; Fiscal Year: 2010
    ..These methods will also be extended to include prior information about molecular mechanisms of gene function, where available, as well as environmental contributions to disease risk. ..
  20. International Collaborative Twin Study of Refractive and Glaucoma Endophenotypes
    Terri Young; Fiscal Year: 2009
    ..This effort may lead to effective therapies for these potentially blinding disorders. ..
  21. QTL mapping for genes regulating apoptosis capacity
    Jianfeng Xu; Fiscal Year: 2010
    ..Our proposal describes a novel and efficient approach to identify apoptosis genes that are critical in cancer susceptibility. ..
  22. Integrative genetic approaches to Atherosclerosis
    Aldons Jake Lusis; Fiscal Year: 2010
    ..In Aim 3 we utilize a series of transgenic/knockout models to test the role of genes at the locus and to validate findings from Aims 1 and 2. ..
  23. The international 1q type 2 diabetes consortium
    MARK IAN MCCARTHY; Fiscal Year: 2010
    ..This information will contribute to future diagnostic and therapeutic advances in the clinical management of this condition. ..
  24. Neural Phenotypes for Schizophrenia and Bipolar Disorder
    Tyrone D Cannon; Fiscal Year: 2010
    ....
  25. A genome-wide association study to detect genetic variation for schizophrenia
    Edwin van den Oord; Fiscal Year: 2010
    ..We attempt to contribute to the rigorous evaluation of the common disease/common genetic variant model for schizophrenia, which is key to further understand its pathophysiology and develop effective treatments. ..
  26. Design/Production of Haplotype Map of the Human Genome
    David Altshuler; Fiscal Year: 2008
    ..The haplotype map project will catalyze human genetic studies of unprecedented power and scope, promising increased insight into disease risk in the population, and ultimately, improved clinical care. ..
  27. Lipoprotein Metabolism 2008 Gordon Research Conference
    Robert Hegele; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  28. Framingham Obesity Genetics
    Larry Atwood; Fiscal Year: 2008
    ..Association tests will be repeated to independently confirm that polymorphisms in this gene have an effect on BMI. ..
  29. Treatment of Nicotine Dependence in Health Care Setting
    Gary Swan; Fiscal Year: 2009
    ....
  30. Biometric and Measured Genetic Research on Smoking
    Gary Swan; Fiscal Year: 2007
    ..Such knowledge will confer new insights about the etiology and progression of smoking and should improve the current understanding of smoking, which is still largely descriptive. ..
  31. Genomics of Susceptibility to Urinary Tract Infections
    WALTER HOPKINS; Fiscal Year: 2007
    ..coli strains or non-E, coil bacteria. These objectives will be accomplished using a well-established mouse model of ascending UTI, genetic linkage analysis, and evaluation of resistance to uropathogens in congenic mice. ..
  32. Gene-gene interaction in nasopharyngeal carcinoma
    YIN YAO; Fiscal Year: 2005
    ..Dr. Yao, PI, has been collaborating with a research group at CCSYSU in this Chinese population and recently reported evidence of linkage to chromosome 4 from a genome-wide search for susceptibility gene. ..
  33. FUNCTION AND CONSERVATION IN GLOBIN LOCUS CONTROL REGION
    Ross Hardison; Fiscal Year: 2001
    ..5 and isolate the binding proteins. ..
  34. 14th Internatinal Symposium on Inherited Diseases
    David Whitcomb; Fiscal Year: 2004
    ..The format, venue, and content are designed to maximize participation, education, translation and implementation of the key elements of the many new findings in the genetics of the pancreas. ..
  35. LINKAGE ANALYSIS METHODS FOR HUMAN GENE MAPPING
    Jurg Ott; Fiscal Year: 2004
    ..Log linear modeling may be applied to multiple linked or unlinked markers and is expected to be a useful tool for modeling interactions between loci. Finally, users will continue to receive rapid and reliable support. ..
  36. Novel approaches in linkage analysis for complex traits
    Mariza de Andrade; Fiscal Year: 2003
    ..No new data will be collected for this grant proposal. The application clearly fits the goal of this NHLBI grant program since it will explore new approaches using an existing data set collected through NHLBI support. ..
  37. POLYMORPHISM/DIVERGENCE IN DROSOPHILA PATHOGEN DEFENSES
    Andrew Clark; Fiscal Year: 2002
    ....
  38. QUANTITATIVE METHODS TO MAP GENES FOR COMPLEX TRAITS
    Jurg Ott; Fiscal Year: 2002
    ..abstract_text> ..
  39. METHODS FOR DYNAMIC IMAGING OF HUMAN BRAIN FUNCTION
    Anders Dale; Fiscal Year: 2002
    ..In Aim 3, the applicants proposed to directly validate their non-invasive estimates via direct comparison with intracranial electrode measurements in patients. ..
  40. GENETICS OF BITTER TASTE PERCEPTION IN HUMANS
    DANIELLE REED; Fiscal Year: 2002
    ..In Specific Aim 3, the P.I. will initiate an evaluation of candidate genes located within the region identified, by screening for variabilities associated with PROP-taster status. ..
  41. PHARMACOKINETICS OF NICOTINE IN TWINS
    Gary Swan; Fiscal Year: 2002
    ..Ultimately, this knowledge may lead to more informed and more finely targeted treatment of individuals who are either susceptible to nicotine addiction or are already addicted to this substance. ..
  42. IDENTIFYING NIDDM GENES USING ADMIXED POPULATIONS
    Mark Shriver; Fiscal Year: 2001
    ..They will verify any positive associations found using sib-pair linkage analysis and the transmission disequilibrium test. ..
  43. Human Genome Sequence Variation & the Inherited Basis
    David Altshuler; Fiscal Year: 2004
    ..abstract_text> ..
  44. Human Genomic Polymorphism in Autism
    Aravinda Chakravarti; Fiscal Year: 2006
    ..In this proposal, we carry on the tradition from the previous funding cycle of developing novel genomic technologies that are of direct relevance to the genetic dissection of complex neuropsychiatric traits. [unreadable] [unreadable]..
  45. Working Memory and Social Functioning in Schizophrenia
    Tyrone Cannon; Fiscal Year: 2007
    ..abstract_text> ..
  46. Genomic variation, hapmap and disease
    David Altshuler; Fiscal Year: 2006
    ..The meeting will consist of invited presentations as well as talks and posters based on abstract submissions. [unreadable] [unreadable] [unreadable] [unreadable]..
  47. CONSTRUCTION AND APPLICATION OF A US ADMIXTURE MAP
    Mark Shriver; Fiscal Year: 2006
    ..From simulation studies, we estimate that about 1000 AIMs will be required for genome-wide mapping with two-way admixture, and about 1500 for admixture between three populations. [unreadable] [unreadable] [unreadable]..
  48. Genes for Tolerance and Immunity Consortium
    Christopher Goodnow; Fiscal Year: 2006
    ..abstract_text> ..
  49. Genome Sequence Variation
    David Altshuler; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  50. Identification of genes controlling TB in murine lungs
    Alexander Apt; Fiscal Year: 2005
    ....
  51. IBANGS Annual Meeting support
    John Crabbe; Fiscal Year: 2005
    ..This young society represents an opportunity to attract a core group of young investigators to alcohol research during their formative years. ..
  52. ANALYZE: Software for Joint Linkage and LD Analysis
    Joseph Terwilliger; Fiscal Year: 2005
    ..These programs will be distributed as part of the expanded ANALYZE software package to be developed in this proposed project. ..
  53. Genome biology of Francisella tularensis populations
    Andrew Benson; Fiscal Year: 2005
    ....
  54. Functional genomics of ethanol craving and naltrexone
    Michael Miles; Fiscal Year: 2008
    ..Together, these findings may identify novel targets for therapeutic intervention in alcoholism. ..
  55. Microarray Analysis of Acute Ethanol Effects in Brain
    Michael Miles; Fiscal Year: 2003
    ..These findings might generate novel insights for the treatment of alcoholism. ..
  56. A Genome-wide Association Study for Early-Onset Myocardial Infarction
    David Altshuler; Fiscal Year: 2009
    ..Successfully identifying common gene variants and novel pathways underlying risk of Ml has the potential to transform understanding, treatment, and prevention of the leading cause of death in the U.S. (End of Abstract) ..
  57. Comparative Functional Genomics of Drosophila Obesity
    Andrew Clark; Fiscal Year: 2009
    ..which particular genes and pathways are most relevant to variation in fat storage homeostasis, and by developing a systems biology approach to make inferences from data that span cellular, endocrine, and whole-organism attributes ..
  58. MOLECULAR CHARACTERIZATION OF ACYL-COA DEHYDROGENASES
    Gerard Vockley; Fiscal Year: 2004
    ..This work will lead to a more complete understanding of the ACD gene family, and ultimately, to an improved ability to diagnose and treat patients with deficiencies of these enzymes. ..
  59. GENETIC STUDIES OF COMMON CONGENITAL HEART DEFECTS
    John Belmont; Fiscal Year: 2004
    ..The proposed studies will provide a base on which to advance genetic analyses of a substantial group of congenital heart defects with the aim of reducing their occurrence and providing new treatment opportunities. ..