Genomes and Genes
Summary: A phenotypic outcome (physical characteristic or disease predisposition) that is determined by more than one gene. Polygenic refers to those determined by many genes, while oligogenic refers to those determined by a few genes.
Publications215 found, 100 shown here
- Finding genes that underlie complex traitsAnne M Glazier
Physiological Genomics and Medicine Group, MRC Clinical Sciences Centre, Hammersmith Hospital, Imperial College Faculty of Medicine, DuCane Road, London W12 0NN, UK
Science 298:2345-9. 2002..These proof-of-concept studies demonstrate the insights that can be expected from the accelerating pace of gene discovery in this field...
- Bayesian inference analyses of the polygenic architecture of rheumatoid arthritisEli A Stahl
Division of Rheumatology Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
Nat Genet 44:483-9. 2012..These analyses suggest that GWAS will continue to be highly productive for the discovery of additional susceptibility loci for common diseases...
- Genome-wide association studies for common diseases and complex traitsJoel N Hirschhorn
Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
Nat Rev Genet 6:95-108. 2005..Genome-wide association studies will soon become possible, and could open new frontiers in our understanding and treatment of disease. However, the execution and analysis of such studies will require great care...
- The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptationJonathan K Pritchard
Department of Human Genetics, The University of Chicago, Room 507, 929 E 58th St, Chicago, IL 60637, USA
Curr Biol 20:R208-15. 2010..We close by discussing some of the likely opportunities for progress in the field...
- Predictive testing for complex diseases using multiple genes: fact or fiction?A Cecile J W Janssens
Erasmus MC, University Medical Center Rotterdam, The Netherlands
Genet Med 8:395-400. 2006..There is ongoing debate about whether testing low-risk genes at multiple loci will be useful in clinical care and public health. We investigated the usefulness of multiple genetic testing using simulated data...
- Common disorders are quantitative traitsRobert Plomin
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London SE5 8AF, UK
Nat Rev Genet 10:872-8. 2009..Research that focuses on quantitative traits - including the low and high ends of normal distributions - could have far-reaching implications for the diagnosis, treatment and prevention of the problematic extremes of these traits...
- Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypothesesP M Visscher
Queensland Institute of Medical Research, Herston, Queensland, Australia
Mol Psychiatry 17:474-85. 2012..We conclude that larger experimental sample sizes are essential to further our understanding of the biology underlying psychiatric disorders...
- Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactionsLance W Hahn
Program in Human Genetics and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
Bioinformatics 19:376-82. 2003..In this paper, we describe the MDR approach and an MDR software package...
- Impacts of both reference population size and inclusion of a residual polygenic effect on the accuracy of genomic predictionZengting Liu
Christian Albert University, Institute of Animal Breeding and Husbandry, 24908 Kiel, Germany
Genet Sel Evol 43:19. 2011..The purpose of this work was to study the impact of both the size of genomic reference populations and the inclusion of a residual polygenic effect on dairy cattle genetic evaluations enhanced with genomic information...
- Polygenes, risk prediction, and targeted prevention of breast cancerPaul D P Pharoah
Department of Oncology, University of Cambridge, United Kingdom
N Engl J Med 358:2796-803. 2008..New developments in the search for susceptibility alleles in complex disorders provide support for the possibility of a polygenic approach to the prevention and treatment of common diseases...
- The modular nature of genetic diseasesM Oti
Centre for Molecular and Biomolecular Informatics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands
Clin Genet 71:1-11. 2007....
- Polygenic variation maintained by balancing selection: pleiotropy, sex-dependent allelic effects and G x E interactionsMichael Turelli
Section of Evolution and Ecology and Center for Population Biology, University of California, Davis 95616, USA
Genetics 166:1053-79. 2004..We present numerical results that support our analytical approximations and discuss our results in connection to relevant data and alternative variance-maintaining mechanisms...
- Polygenic dissection of the bipolar phenotypeM L Hamshere
MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, UK
Br J Psychiatry 198:284-8. 2011..Recent data provide strong support for a substantial common polygenic contribution (i.e. many alleles each of small effect) to genetic susceptibility for schizophrenia and overlapping susceptibility for bipolar disorder...
- Evidence for polygenic susceptibility to multiple sclerosis--the shape of things to comeWilliam S Bush
Vanderbilt University, USA
Am J Hum Genet 86:621-5. 2010....
- Adaptation - not by sweeps aloneJonathan K Pritchard
Department of Human Genetics, Howard Hughes Medical Institute, University of Chicago, Illinois 60615, USA
Nat Rev Genet 11:665-7. 2010..Jonathan Pritchard and Anna Di Rienzo argue that many adaptive events in natural populations may occur by polygenic adaptation, which would largely go undetected by conventional methods for detecting selection...
- Recent methods for polygenic analysis of genome-wide data implicate an important effect of common variants on cardiovascular disease riskMatthew A Simonson
Department of Psychology, University of Colorado Boulder, USA
BMC Med Genet 12:146. 2011....
- The influence of polygenic risk for bipolar disorder on neural activation assessed using fMRIH C Whalley
Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
Transl Psychiatry 2:e130. 2012..The findings suggest that this novel polygenic approach to examine brain-imaging data may be a useful means of identifying genetically mediated traits mechanistically linked to the aetiology of BD...
- The genetic dissection of complex traits in a founder populationC Ober
Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA
Am J Hum Genet 69:1068-79. 2001..However, even in this young founder population that has extensive linkage disequilibrium, map densities <<5 cM may be required to detect all major QTLs...
- Genetic and environmental effects on complex traits in miceWilliam Valdar
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
Genetics 174:959-84. 2006..Our results indicate that assays of gene function using mouse models should take into account interactions between gene and environment...
- Candidate-gene approaches for studying complex genetic traits: practical considerationsHolly K Tabor
Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305 5120, USA
Nat Rev Genet 3:391-7. 2002..We believe that these criticisms can be usefully countered with an appeal to the principles of epidemiological investigation...
- Relaxed significance criteria for linkage analysisLin Chen
Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA
Genetics 173:2371-81. 2006..A generalized version of the GWER is proposed, called GWERk, that allows one to provide a more liberal balance between true positives and false positives at no additional cost in computation or assumptions...
- Heritability of cardiovascular and personality traits in 6,148 SardiniansGiuseppe Pilia
Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche, Ospedale Microcitemico, Cagliari, Italy
PLoS Genet 2:e132. 2006..Evidence for heterogeneity by age and sex suggests that models allowing for these differences will be important in mapping quantitative traits...
- Major gene and multifactorial inheritance of mandibular prognathismRicardo Machado Cruz
Departament of Genetics and Morphology, University of Brasilia, Brasilia, DF, Brazil
Am J Med Genet A 146:71-7. 2008..316. We conclude that there is a major gene that influences the expression of mandibular prognathism with clear signs of Mendelian inheritance and a multifactorial component...
- Polygenic modeling of genome-wide association studies: an application to prostate and breast cancerJohn S Witte
Institute for Human Genetics, Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA
OMICS 15:393-8. 2011..This supports the further development and application of polygenic models to genomic data...
- Polygenic and directional regulatory evolution across pathways in SaccharomycesJames H Bullard
Division of Biostatistics, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Proc Natl Acad Sci U S A 107:5058-63. 2010..We suggest that pathway analyses, including our test for directional regulatory evolution, will prove to be a relevant and powerful strategy in many evolutionary genomic applications...
- Genomewide scans of complex human diseases: true linkage is hard to findJ Altmuller
Institute of Epidemiology, GSF corrected National Research Center for Environment and Health, Neuherberg, Germany
Am J Hum Genet 69:936-50. 2001..Positional cloning based on whole-genome screens in complex human disease has proved more difficult than originally had been envisioned; detection of linkage and positional cloning of specific disease-susceptibility loci remains elusive...
- Domestic-animal genomics: deciphering the genetics of complex traitsLeif Andersson
Department of Medical Biochemistry and Microbiology, Uppsala University, Box 597, SE 751 24 Uppsala, Sweden
Nat Rev Genet 5:202-12. 2004
- Environmental and genetic risk factors in obesityJohannes Hebebrand
Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Virchowstr, 174, D 45147 Essen, Germany
Child Adolesc Psychiatr Clin N Am 18:83-94. 2009..Important factors are socioeconomic status and television consumption. The authors conclude by briefly assessing implications for treatment and prevention of childhood obesity...
- Polygenic inherited predisposition to breast cancerB A J Ponder
Department of Oncology and Public Health and Cancer Research UK Genetic Epidemiology Unit, Strangeways Research Laboratories, University of Cambridge, UK
Cold Spring Harb Symp Quant Biol 70:35-41. 2005..A key unanswered question is the "genetic architecture" of predisposition-that is, strong or weak alleles, common or rare. We describe a genome-wide scan designed to provide a first-pass answer to this question...
- Accuracy of breeding values when using and ignoring the polygenic effect in genomic breeding value estimation with a marker density of one SNP per cMM P L Calus
Animal Breeding and Genomics Centre, Animal Sciences Group, Wageningen University and Research Centre, Lelystad, The Netherlands
J Anim Breed Genet 124:362-8. 2007..The haplotype variance was less underestimated when more animals were added in the reference dataset...
- A genomic screen of autism: evidence for a multilocus etiologyN Risch
Department of Genetics, M322, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
Am J Hum Genet 65:493-507. 1999..Our results suggest that positional cloning of susceptibility loci by linkage analysis may be a formidable task and that other approaches may be necessary...
- A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemiaRobert A Hegele
Vascular Biology Research Group, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
Hum Mol Genet 18:4189-94. 2009....
- Beyond Mendel: an evolving view of human genetic disease transmissionJose L Badano
Institute of Genetic Medicine, Johns Hopkins University, 2 127 Jefferson Street Building, Baltimore, Maryland 21287, USA
Nat Rev Genet 3:779-89. 2002....
- Narrowing the boundaries of the genetic architecture of schizophreniaNaomi R Wray
Genetic Epidemiology and Queensland Statistical Genetics, Queensland Institute of Medical Research, 330 Herston Road, Brisbane 4029, Australia
Schizophr Bull 36:14-23. 2010..The first generation of studies have generated hypotheses that should be testable in the near future and will further narrow the boundaries on genetic architectures that are consistent with empirical data...
- A genome scan for familial combined hyperlipidemia reveals evidence of linkage with a locus on chromosome 11B E Aouizerat
Departments of 1Microbiology and Molecular Genetics, Medicine, Human Genetics, Molecular Biology Institute, University of California, UCLA School of Medicine Los Angeles, CA 90095 1679, USA
Am J Hum Genet 65:397-412. 1999..This region does not contain any strong candidate genes. These results provide evidence for a candidate chromosomal region for FCHL and support the concept that FCHL is complex and heterogeneous...
- Empirically derived phenotypic subgroups - qualitative and quantitative trait analysesMarsha A Wilcox
Genetics Program, Department of Medicine, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts 02118, USA
BMC Genet 4:S15. 2003....
- Polygenic determinants of severe hypertriglyceridemiaJian Wang
Vascular Biology Research Group 2 Clinical Trials Group, Robarts Research Institute and Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
Hum Mol Genet 17:2894-9. 2008..At the extremes of a quantitative trait, such as severe HTG, are found the cumulative contributions of both multiple rare alleles with large genetic effects and common alleles with small effects...
- Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12Jianfeng Xu
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, 27157, USA
Am J Hum Genet 71:646-50. 2002..06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LOD = 1.86, D12S375). Our results provide evidence that a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits...
- A polygenic basis for late-onset diseaseAlan Wright
MRC Human Genetics Unit, Western General Hospital, Crewe Road, EH4 2XU, Edinburgh, UK
Trends Genet 19:97-106. 2003..The origin and nature of this variation suggests that current strategies are poorly suited to identifying genes involved in many complex diseases...
- Genetic Analysis Workshop 13: simulated longitudinal data on families for a system of oligogenic traitsE Warwick Daw
Department of Epidemiology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
BMC Genet 4:S3. 2003....
- Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autismD Q Ma
Center for Human Genetics, Duke University Medical Center, Durham, NC 27710, USA
Am J Hum Genet 77:377-88. 2005..These results support the hypothesis that GABA receptor subunit genes are involved in autism, most likely via complex gene-gene interactions...
- Polygenic obesity in humansAnke Hinney
Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
Obes Facts 1:35-42. 2008..In the first GWA for extreme early onset obesity we substantiated that variation in FTO strongly contributes to early onset obesity...
- Estimating polygenic effects using markers of the entire genomeShizhong Xu
Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
Genetics 163:789-801. 2003..Similar results were found from simulated data sets of F(2) and backcross (BC) families...
- The genome-wide association study--a new era for common polygenic disordersRobert Roberts
The Ruddy Canadian Cardiovascular Genetics Centre, Ottawa, Ontario, Canada
J Cardiovasc Transl Res 3:173-82. 2010..This will require a new approach involving several disciplines, namely, bioinformatics, high-throughput cell expression, and animal models...
- Rare variant hypothesis for multifactorial inheritance: susceptibility to colorectal adenomas as a modelNicola S Fearnhead
Cancer Research U K Cancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, Oxford, UK
Cell Cycle 4:521-5. 2005..Recent evidence suggests that a quarter of patients with multiple adenomatous polyps are due to rare but functionally important variants in just five genes...
- Persistence of accuracy of genome-wide breeding values over generations when including a polygenic effectTrygve R Solberg
Norwegian University of Life Sciences, Department of Animal and Aquacultural Sciences, PO Box 5003, N 1432 As, Norway
Genet Sel Evol 41:53. 2009....
- Implications of multifactorial inheritance for identification of genetic mechanisms in major psychiatric disordersJohn I Nurnberger
Psychiatr Genet 12:121-6. 2002
- The effect of reduction in cross-validation intervals on the performance of multifactor dimensionality reductionAlison A Motsinger
Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0700, USA
Genet Epidemiol 30:546-55. 2006..The validity of this reduction was confirmed with data from an Alzheimer's disease (AD) study...
- Imputation methods for missing data for polygenic modelsBrooke Fridley
Department of Statistics, Iowa State University, Ames, Iowa, USA
BMC Genet 4:S42. 2003..Thus, we recommend the Gibbs sampler for imputation purposes because of the ease with which it can be extended to more complicated models, the consistency of the results, and the accountability of the variation due to imputation...
- Sib-pairs in multifactorial disorders: the sib-similarity problemJ H Edwards
Department of Biochemistry, University of Oxford, South Parks Road, Oxford, UK
Clin Genet 63:1-9. 2003..Possible reasons for this limited success and the many suggestive false positives are considered...
- Longitudinal variance-components analysis of the Framingham Heart Study dataStuart Macgregor
Biostatistics and Bioinformatics Unit, University of Wales College of Medicine, Heath Hospital, Cardiff, United Kingdom
BMC Genet 4:S22. 2003..The traits of interest were BMI, HDLC, total cholesterol, and height. The longitudinal method allowed the characterization of the change in QTL effects with aging. A QTL affecting BMI was shown to act mainly at early ages...
- Whole-genome patterns of common DNA variation in three human populationsDavid A Hinds
Perlegen Sciences Inc, 2021 Stierlin Court, Mountain View, CA 94043, USA
Science 307:1072-9. 2005..Our data provide a tool for exploring many questions that remain regarding the causal role of common human DNA variation in complex human traits and for investigating the nature of genetic variation within and between human populations...
- Adult-onset Alopecia areata is a complex polygenic trait in the C3H/HeJ mouse modelJohn P Sundberg
The Jackson Laboratory, Bar Harbor, Maine 04609 1500, USA
J Invest Dermatol 123:294-7. 2004..These results indicate the necessity of integrating both gene association and genome-wide linkage studies in both mice and humans to understand the complex nature of these and other polygenic diseases...
- Gene-environment interactions in complex diseases: genetic models and methods for QTL mapping in multiple half-sib populationsHaja N Kadarmideen
Statistical Animal Genetics Group, Institute of Animal Science, Swiss Federal Institute of Technology, ETH Zentrum UNS D7, Universitaetstrasse 65, Zurich 8092, Switzerland
Genet Res 88:119-31. 2006..Top-down model selection is proposed in which a full test for QEI is conducted first and then the model is subsequently simplified. Methods and results will be applicable to human, plant and animal QTL mapping experiments...
- Within-family marker-assisted selection for aquaculture speciesAnna K Sonesson
AKVAFORSK Institute of Aquaculture Research Ltd, P O Box 5010, 1432 As, Norway
Genet Sel Evol 39:301-17. 2007..There was no significant difference in polygenic genetic gain between MAS and NONMAS for most schemes. The rates of inbreeding were lower for MAS than NON-MAS schemes, because fewer full-sibs were selected by MAS...
- Bayesian inference on major loci in related multigeneration selection lines of laying hensC Hagger
Breeding Biology Group, Institute of Animal Science, Swiss Federal Institute of Technology, ETH Zentrum, CH 8092 Zurich, Switzerland
Poult Sci 83:1932-9. 2004..The detection of a major locus with relatively modest effect confirmed that this type of analysis with data from selected lines was indeed powerful...
- [New strategies in schizophrenia: impact of endophentotypes]Carolin Opgen-Rhein
Klinik und Hochschulambulanz für Psychiatrie und Psychotherapie, Charite Universitatsmedizin Berlin
Psychiatr Prax 31:S194-9. 2004....
- Genetics. Harvesting medical information from the human family treeDavid Altshuler
Broad Institute of Harvard and Massachusetts Institute of Technology, and Massachusetts General Hospital, Boston, MA 02114, USA
Science 307:1052-3. 2005
- Epistasis and balanced polymorphism influencing complex trait variationJuergen Kroymann
Max Planck Institute for Chemical Ecology, Department of Genetics and Evolution, Hans Knoell Str 8, D 07745 Jena, Germany
Nature 435:95-8. 2005..If this region typifies many complex trait loci, then non-neutral epistatic polymorphism may be an important contributor to genetic variation in complex traits...
- Genome-wide quantitative trait locus association scan of general cognitive ability using pooled DNA and 500K single nucleotide polymorphism microarraysL M Butcher
Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
Genes Brain Behav 7:435-46. 2008..11 (P < 0.00000003) with g. This shows that future SNP sets that will incorporate many more SNPs could be useful for predicting genetic risk and for investigating functional systems of effects from genes to brain to behavior...
- Genetics of metabolic syndrome: is there a role for phenomics?Tisha Joy
Robarts Research Institute, 406 100 Perth Drive, London, Ontario, N6A 5K8, Canada
Curr Atheroscler Rep 10:201-8. 2008....
- Common and rare alleles as causes of complex phenotypesConstantin Polychronakos
Montreal Children s Hospital, 2300 Tupper Street, Suite C244, Montreal, Quebec, H3H 1P3, Canada
Curr Atheroscler Rep 10:194-200. 2008..Because the models are not mutually exclusive, the question should be not which model is correct, but rather what is the relative contribution of each, which is something that may vary dramatically among traits...
- Candidate genes for obesity revealed from a C57BL/6J x 129S1/SvImJ intercrossZ Su
The Jackson Laboratory, Bar Harbor, ME 04609, USA
Int J Obes (Lond) 32:1180-9. 2008..To identify the genes controlling body fat, we carried out a quantitative trait locus (QTL) analysis using C57BL/6J (B6) and 129S1/SvImJ (129) mice, which differ in obesity susceptibility after consuming an atherogenic diet...
- Two-stage designs to identify the effects of SNP combinations on complex diseasesGuolian Kang
Key Laboratory of Systems and Control, Institute of Systems Science, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, 100080, China
J Hum Genet 53:739-46. 2008..Using synergistic blocks, we can reduce the dimensionality in a multi-locus association analysis, and evaluate the sizes of interactive effects among multiple disease genes on complex phenotypes...
- Mapping quantitative trait loci for longitudinal traits in line crossesRunqing Yang
School of Agriculture and Biology, Shanghai Jiaotong University, People s Republic of China
Genetics 173:2339-56. 2006..The method is verified with simulated data and demonstrated with experimental data from a pseudobackcross family of Populus (poplar) trees...
- Segregation analysis of a complex quantitative trait: approaches for identifying influential data pointsRobert P Igo
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
Hum Hered 61:80-6. 2006..Here we use an oligogenic Bayesian Markov chain Monte Carlo method for SA (OSA) to verify results from a single-locus likelihood-based CSA for data on a quantitative measure of reading ability...
- A proposal concept of a polygene network in systemic vasculitis: lessons from MRL mouse modelsMasato Nose
Department of Pathogenomics, Ehime University Graduate School of Medicine, Ehime, Japan
Allergol Int 56:79-86. 2007..This is designated as the polygene network in systemic vasculitis...
- The efficiency of mapping of quantitative trait loci using cofactor analysis in half-sib designGoutam Sahana
Department of Genetics and Biotechnology, Danish Institute of Agricultural Sciences, Research Centre Foulum, Tjele, 8830, Denmark
Genet Sel Evol 38:167-82. 2006..Our study shows that cofactor analysis increased the number of false positives in all scenarios with low heritability and the increase was up to 50% in low power experiments and with lower thresholds for cofactors...
- Resolving the IQ paradox: heterosis as a cause of the Flynn effect and other trendsMichael A Mingroni
Psychol Rev 114:806-29. 2007..The goal of the modeling is to develop a quantitatively rigorous method for estimating the potential contribution of heterosis in the Flynn effect, as well as trends observed in other heritable traits and conditions...
- Discrete polymorphisms due to disruptive selection on a continuous trait--I: the one-locus caseCarlo Matessi
Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche, via Abbiategrasso 207, IT 27100 Pavia, Italy
Theor Popul Biol 69:283-95. 2006..In this case a population at the long-term equilibrium might even be genetically monomorphic, with the phenotypic dimorphism resulting from purely random individual variation...
- Cardiovascular genomicsMarc S Sabatine
Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Circulation 113:e450-5. 2006
- A molecular selection index method based on eigenanalysisJ Jesús Cerón-Rojas
Colegio de Postgraduados, Carretera México Texcoco, Montecillo, Estado de Mexico, Mexico
Genetics 180:547-57. 2008....
- [Multifactorial diseases: a nightmare for the geneticist]Josue Feingold
INSERM U 393, Hopital Necker Enfants Malades, 149, rue de Sevres, 75015 Paris, France
Med Sci (Paris) 21:927-33. 2005..Most of the results have not been replicated, identifying susceptibility genes is proving much more difficult than most geneticists imagined 20 years ago. The main reason for this irreproducibility is genetic heterogeneity...
- Bioinformatics and approaches to identifying polygenic susceptibility traitsBruce S Weir
Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
Ann Periodontol 7:1-7. 2002..Current thinking tends to focus on relatively conserved "haplotype blocks" instead of single genetic markers, although there is no consensus on the utility of this emphasis...
- Genetic aspects of hypertension and metabolic disease in the obstructive sleep apnoea-hypopnoea syndromeRenata L Riha
Department of Sleep Medicine, Royal Infirmary Edinburgh, 51 Little France Crescent, Little France, Edinburgh, UK
Sleep Med Rev 12:49-63. 2008..This review focuses on genetic factors, which may be responsible for the expression of cardiovascular disease and metabolic syndrome in the context of OSAHS...
- MCMC-based linkage analysis for complex traits on general pedigrees: multipoint analysis with a two-locus model and a polygenic componentYun Ju Sung
Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195 7720, USA
Genet Epidemiol 31:103-14. 2007..Our examples illustrate the advantage of parametric linkage analysis with two QTLs, which provides higher power for linkage detection and better localization than use of simpler models...
- A study on the minimum number of loci required for genetic evaluation using a finite locus modelLiviu R Totir
Department of Animal Science, Iowa State University, Ames, IA 50011, USA
Genet Sel Evol 36:395-414. 2004..For highly heritable traits, models with up to six loci were needed to match the evaluations obtained by BLP...
- Detection of quantitative trait loci affecting caffeine metabolism by interval mapping in a genome-wide scan of C3H/HeJ x APN F(2) miceW L Casley
Research Division, Therapeutic Products Programme, Health Canada
Drug Metab Dispos 27:1375-80. 1999..This study demonstrates the utility of quantitative genetics in the analysis of polygenic drug metabolism...
- Novel approaches to identify low-penetrance cancer susceptibility genes using mouse modelsJohn P de Koning
UCSF Comprehensive Cancer Center and Cancer Research Institute, Department of Biochemistry and Biophysics, University of California San Francisco, 2340 Sutter Street, San Francisco, CA 94115, USA
Recent Results Cancer Res 163:19-27; discussion 264-6. 2003..Novel approaches that might accelerate the identification of these low-penetrance cancer susceptibility genes by using mouse models will be discussed...
- Loci on chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strainsDanielle R Reed
Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
Mamm Genome 14:302-13. 2003..These results reinforce the concept that obesity is a complex trait. Genetic loci and their interactions, in conjunction with sex, age, and diet, determine body size and adiposity in mice...
- Early onset albuminuria in Dahl rats is a polygenetic trait that is independent from salt loadingAli Poyan Mehr
Institute of Clinical Pharmacology and Toxicology, Universitätsklinikum Benjamin Franklin Hospital, Freie Universitat Berlin, Germany
Physiol Genomics 14:209-16. 2003..Thus early onset albuminuria in the SS rat is under polygenetic influence and independent from salt loading...
- The complexity of complex diseasesP Michael Conneally
Department of Medical and Molecular Genetics, Indiana University, Indianapolis, 46202 5251, USA
Am J Hum Genet 72:229-32. 2003
- A further look at quantitative trait loci affecting growth and fatness in a cross between Meishan and Large White pig populationsRaquel Quintanilla
Station de Génétique Quantitative et Appliquée, Institut National de la Recherche Agronomique, 78352 Jouy en Josas Cedex, France
Genet Sel Evol 34:193-210. 2002..The second QTL had a favourable LW allele and was located in the proximal extremity of the q arm of chromosome 1. Suggestive genomic imprinting was found in the distal region of chromosome 9 affecting growth during the fattening period...
- Power of a simplified multivariate test for genetic linkageO Y Gorlova
Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Ann Hum Genet 66:407-17. 2002..The method identified meaningful combinations of traits that showed significant linkage on chromosome 2 and suggestive linkage to regions on chromosomes 16 and 17...
- Backward Haplotype Transmission Association (BHTA) algorithm - a fast multiple-marker screening methodShaw Hwa Lo
Department of Statistics, Columbia University, New York, NY 10027, USA
Hum Hered 53:197-215. 2002..Detailed theoretical justifications are also included, which explains why the algorithm is likely to select the 'correct' markers...
- A unified approach to joint modeling of multiple quantitative and qualitative traits in gene mappingJukka Corander
Rolf Nevanlinna Institute, University of Helsinki, 4, Finland
J Theor Biol 218:435-46. 2002..Outline of the possible implementation of the Bayesian method is described using the general reversible-jump Markov chain Monte Carlo algorithm. Some future challenges and extensions are also discussed...
- Voluntary ethanol consumption by mice: genome-wide analysis of quantitative trait loci and their interactions in a C57BL/6ByJ x 129P3/J F2 intercrossAlexander A Bachmanov
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA
Genome Res 12:1257-68. 2002..However, there were a few modifiers of the primary linkages and a number of interactions among unlinked loci. This demonstrates a significant role of the genetic background in the variation of ethanol consumption...
- Mapping quantitative effects of oligogenes by allelic associationW Zhang
Human Genetics Division, Southampton General Hospital, UK
Ann Hum Genet 66:211-21. 2002..However, rigorous confirmation requires that the causal SNPs be identified. Both Malecot and parametric analysis appear to have high power by comparison with alternative methods for localizing oligogenes and their causal polymorphisms...
- Toward positional cloning with SNPsNewton E Morton
Human Genetics, Southampton General Hospital, UK
Curr Opin Mol Ther 4:259-64. 2002....
- Optimal selection on two quantitative trait loci with linkageJack C M Dekkers
Department of Animal Science, 225 Kildee Hall, Iowa State University Ames, IA 50011, USA
Genet Sel Evol 34:171-92. 2002..These results demonstrate the ability of optimal selection to capitalize on information on the complex genetic basis of quantitative traits that is forthcoming...
- A novel approach to search for identity by descent in small samples of patients and controls from the same mendelian breeding unit: a pilot study on myopiaS Heath
Department of Human Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Hum Hered 52:183-90. 2001..The iterative application of our strategy in separate MBUs is expected to become the method of choice to evaluate the ever-growing number of reported associations between candidate genes and multifactorial traits and diseases...
- Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crossesR J Roper
Department of Veterinary Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA
Genes Immun 2:388-97. 2001..Interestingly, some alleles contributing to susceptibility to Lyme arthritis were derived from C57BL/6N and BALB/cAnN mice, showing that disease-resistant strains harbor susceptibility alleles...
- Evidence for further breast cancer susceptibility genes in addition to BRCA1 and BRCA2 in a population-based studyA C Antoniou
CRC Genetic Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom
Genet Epidemiol 21:1-18. 2001....
- Accuracy of marker-assisted selection with auxiliary traitsP Narain
J Biosci 28:569-79. 2003....
- Conditional multipoint linkage analysis using affected sib pairs: an alternative approachYen Feng Chiu
Division of Biostatistics and Bioinformatics, National Health Research Institutes, Taiwan, R O C
Genet Epidemiol 26:108-15. 2004..The performance of both approaches is quite comparable showing consistent estimates of the trait locus and key genetic parameters...
- Consistency of linkage results across exams and methods in the Framingham Heart StudyLarry D Atwood
Department of Neurology, Boston University School of Medicine, 715 Albany Street, Boston, Massachusetts, USA
BMC Genet 4:S30. 2003..We compared regression-based linkage to variance components linkage across time for six quantitative traits in the real data...
- Integrative genomics: in silico coupling of rat physiology and complex traits with mouse and human dataSimon N Twigger
Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
Genome Res 14:651-60. 2004..Integrating rat physiology with mouse genetics and clinical results from human by using the respective genomes provides a novel route to capitalize on comparative genomics and the strengths of model organism biology...
- Evidence for bivariate linkage of obesity and HDL-C levels in the Framingham Heart StudyRector Arya
Division of Clinical Epidemiology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
BMC Genet 4:S52. 2003..Subsequently, we performed bivariate multipoint linkage analysis to detect common loci influencing covariation between these two traits...
- A simulation study concerning the effect of varying the residual phenotypic correlation on the power of bivariate quantitative trait loci linkage analysisDavid M Evans
Queensland Institute of Medical Research and Joint Genetics Program, University of Queensland, PO Royal Brisbane Hospital, Brisbane 4029, Australia
Behav Genet 34:135-41. 2004..g., from multivariate structural equation modeling of twin data) or a sound theoretical argument that the QTL and environmental factors induce covariation in opposite directions...
- [Estimating family correlation of quantitative traits using generalized estimating equation]Yan Hui Gao
Department of Epidemiology, College of Public Health, Fudan University, Shanghai 200032, China
Zhonghua Liu Xing Bing Xue Za Zhi 24:729-33. 2003..To study the method for measuring familial correlations of quantitative trait and analyzing family data set of body height...
- Mapping complex traits using Random ForestsAlexandre Bureau
Genome Therapeutics Corporation, Waltham, Massachusetts 02453, USA
BMC Genet 4:S64. 2003..Random Forest was able to identify a few of the major genes influencing the phenotypes, such as baseline HDL and triglycerides, but failed to identify the major genes regulating baseline glucose levels...
- ORAL-FACIAL CLEFTS IN CHINAMichael Melnick; Fiscal Year: 1990..effects and utilization of a variety of segregation analyses to test for single major gene inheritance, multifactorial inheritance, mixed inheritance, etc...
- BAYLOR BIRCWH PROGRAMJoe Simpson; Fiscal Year: 2004..These goals are vital to public health in contributing to the establishment of methods for production of safe, effective, quality herbal extracts for consumer use. ..
- CYP1A1 GENE AND ENVIRONMENTAL TOXICITYDaniel Nebert; Fiscal Year: 2005..abstract_text> ..
- Linkage Disequilibrium Methods For Complex Trait MappingJonathan Pritchard; Fiscal Year: 2007..The long term goal of this project is to develop statistical/computational tools and models of LD that can be of practical use to complex trait mapping community, and will contribute to cheaper and more effective studies. ..
- PAHs: Balance of Detoxication vs Metabolic ActivationDaniel Nebert; Fiscal Year: 2009..dissemination of ingested BaP and will be informative in clinical studies in which we would determine which haplotypes of these three human genes might be associated with resistance vs. sensitivity to PAH-induced toxicity and cancer. ..
- Molecular Genetics of Cadmium ToxicityDaniel W Nebert; Fiscal Year: 2010....
- GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICEDaniel Nebert; Fiscal Year: 2002..S. population. ..
- LINKAGE ANALYSIS METHODS IN SCHIZOPHRENIAJurg Ott; Fiscal Year: 2008..Computer programs and methods obtained through this work will be made available to researchers. ..
- Association of inflammatory genes and prostate cancerJianfeng Xu; Fiscal Year: 2008..Answers to these questions will significantly improve our knowledge of the role of inflammation in prostate cancer and will guide our efforts in identifying additional prostate cancer genes. ..
- Impact of Smoking Cessation on SleepGary Swan; Fiscal Year: 2008..The results of this project will be particularly important for the development of targeted treatment approaches designed to ameliorate sleep disruption as part of an overall smoking cessation strategy. ..
- GENETIC ANALYSIS OF HIRSCHSPRUNG DISEASEAravinda Chakravarti; Fiscal Year: 2008..The long-term objective of this study is to understand the molecular genetic basis of HSCR. More generally, our aim is to develop a paradigm for sequence-based biology in complex, human diseases. [unreadable] [unreadable]..
- In silico genome scan with high-throughput addiction related phenotypes in miceEdwin van den Oord; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Pathways to Alcohol ToleranceBoris Tabakoff; Fiscal Year: 2006..In all, our studies should provide an excellent foundation for understanding the neuroadaptive processes leading to ethanol tolerance in reference to the anxiolytic action of this drug. ..
- The Role of Toll-Like Receptors in NPCYIN YAO; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Genetic epidemiology of irritable bowel syndrome (IBS)YURI SAITO LOFTUS; Fiscal Year: 2008....
- MOLECULAR GENETICS OF HEREDITARY PANCREATITISDavid Whitcomb; Fiscal Year: 2008..The HP and familial pancreatitis studies are especially important because of the statistical power of family studies and the ability to detect modifier genes in a uniform background of susceptibility factors. ..
- Interaction of PTEN and CDKN1B in Pca susceptibilityJianfeng Xu; Fiscal Year: 2008..The results from this study are likely to significant advance our knowledge of prostate cancer risk and begin to explore the underlying biological mechanisms for any observed differences. ..
- Genome-wide association of common alleles with long-term diabetic complicationsAndrew Paterson; Fiscal Year: 2008..unreadable] [unreadable]..
- Inferring Multiple-SNP Disease Association with DNA Resequence DataRasmus Nielsen; Fiscal Year: 2010..These methods will also be extended to include prior information about molecular mechanisms of gene function, where available, as well as environmental contributions to disease risk. ..
- International Collaborative Twin Study of Refractive and Glaucoma EndophenotypesTerri Young; Fiscal Year: 2009..This effort may lead to effective therapies for these potentially blinding disorders. ..
- QTL mapping for genes regulating apoptosis capacityJianfeng Xu; Fiscal Year: 2010..Our proposal describes a novel and efficient approach to identify apoptosis genes that are critical in cancer susceptibility. ..
- Integrative genetic approaches to AtherosclerosisAldons Jake Lusis; Fiscal Year: 2010..In Aim 3 we utilize a series of transgenic/knockout models to test the role of genes at the locus and to validate findings from Aims 1 and 2. ..
- The international 1q type 2 diabetes consortiumMARK IAN MCCARTHY; Fiscal Year: 2010..This information will contribute to future diagnostic and therapeutic advances in the clinical management of this condition. ..
- Neural Phenotypes for Schizophrenia and Bipolar DisorderTyrone D Cannon; Fiscal Year: 2010....
- A genome-wide association study to detect genetic variation for schizophreniaEdwin van den Oord; Fiscal Year: 2010..We attempt to contribute to the rigorous evaluation of the common disease/common genetic variant model for schizophrenia, which is key to further understand its pathophysiology and develop effective treatments. ..
- Design/Production of Haplotype Map of the Human GenomeDavid Altshuler; Fiscal Year: 2008..The haplotype map project will catalyze human genetic studies of unprecedented power and scope, promising increased insight into disease risk in the population, and ultimately, improved clinical care. ..
- Lipoprotein Metabolism 2008 Gordon Research ConferenceRobert Hegele; Fiscal Year: 2008..End of Abstract) [unreadable] [unreadable] [unreadable]..
- Framingham Obesity GeneticsLarry Atwood; Fiscal Year: 2008..Association tests will be repeated to independently confirm that polymorphisms in this gene have an effect on BMI. ..
- Treatment of Nicotine Dependence in Health Care SettingGary Swan; Fiscal Year: 2009....
- Biometric and Measured Genetic Research on SmokingGary Swan; Fiscal Year: 2007..Such knowledge will confer new insights about the etiology and progression of smoking and should improve the current understanding of smoking, which is still largely descriptive. ..
- Genomics of Susceptibility to Urinary Tract InfectionsWALTER HOPKINS; Fiscal Year: 2007..coli strains or non-E, coil bacteria. These objectives will be accomplished using a well-established mouse model of ascending UTI, genetic linkage analysis, and evaluation of resistance to uropathogens in congenic mice. ..
- Gene-gene interaction in nasopharyngeal carcinomaYIN YAO; Fiscal Year: 2005..Dr. Yao, PI, has been collaborating with a research group at CCSYSU in this Chinese population and recently reported evidence of linkage to chromosome 4 from a genome-wide search for susceptibility gene. ..
- FUNCTION AND CONSERVATION IN GLOBIN LOCUS CONTROL REGIONRoss Hardison; Fiscal Year: 2001..5 and isolate the binding proteins. ..
- 14th Internatinal Symposium on Inherited DiseasesDavid Whitcomb; Fiscal Year: 2004..The format, venue, and content are designed to maximize participation, education, translation and implementation of the key elements of the many new findings in the genetics of the pancreas. ..
- LINKAGE ANALYSIS METHODS FOR HUMAN GENE MAPPINGJurg Ott; Fiscal Year: 2004..Log linear modeling may be applied to multiple linked or unlinked markers and is expected to be a useful tool for modeling interactions between loci. Finally, users will continue to receive rapid and reliable support. ..
- Novel approaches in linkage analysis for complex traitsMariza de Andrade; Fiscal Year: 2003..No new data will be collected for this grant proposal. The application clearly fits the goal of this NHLBI grant program since it will explore new approaches using an existing data set collected through NHLBI support. ..
- POLYMORPHISM/DIVERGENCE IN DROSOPHILA PATHOGEN DEFENSESAndrew Clark; Fiscal Year: 2002....
- QUANTITATIVE METHODS TO MAP GENES FOR COMPLEX TRAITSJurg Ott; Fiscal Year: 2002..abstract_text> ..
- METHODS FOR DYNAMIC IMAGING OF HUMAN BRAIN FUNCTIONAnders Dale; Fiscal Year: 2002..In Aim 3, the applicants proposed to directly validate their non-invasive estimates via direct comparison with intracranial electrode measurements in patients. ..
- GENETICS OF BITTER TASTE PERCEPTION IN HUMANSDANIELLE REED; Fiscal Year: 2002..In Specific Aim 3, the P.I. will initiate an evaluation of candidate genes located within the region identified, by screening for variabilities associated with PROP-taster status. ..
- PHARMACOKINETICS OF NICOTINE IN TWINSGary Swan; Fiscal Year: 2002..Ultimately, this knowledge may lead to more informed and more finely targeted treatment of individuals who are either susceptible to nicotine addiction or are already addicted to this substance. ..
- IDENTIFYING NIDDM GENES USING ADMIXED POPULATIONSMark Shriver; Fiscal Year: 2001..They will verify any positive associations found using sib-pair linkage analysis and the transmission disequilibrium test. ..
- Human Genome Sequence Variation & the Inherited BasisDavid Altshuler; Fiscal Year: 2004..abstract_text> ..
- Human Genomic Polymorphism in AutismAravinda Chakravarti; Fiscal Year: 2006..In this proposal, we carry on the tradition from the previous funding cycle of developing novel genomic technologies that are of direct relevance to the genetic dissection of complex neuropsychiatric traits. [unreadable] [unreadable]..
- Working Memory and Social Functioning in SchizophreniaTyrone Cannon; Fiscal Year: 2007..abstract_text> ..
- Genomic variation, hapmap and diseaseDavid Altshuler; Fiscal Year: 2006..The meeting will consist of invited presentations as well as talks and posters based on abstract submissions. [unreadable] [unreadable] [unreadable] [unreadable]..
- CONSTRUCTION AND APPLICATION OF A US ADMIXTURE MAPMark Shriver; Fiscal Year: 2006..From simulation studies, we estimate that about 1000 AIMs will be required for genome-wide mapping with two-way admixture, and about 1500 for admixture between three populations. [unreadable] [unreadable] [unreadable]..
- Genes for Tolerance and Immunity ConsortiumChristopher Goodnow; Fiscal Year: 2006..abstract_text> ..
- Genome Sequence VariationDavid Altshuler; Fiscal Year: 2006..unreadable] [unreadable]..
- Identification of genes controlling TB in murine lungsAlexander Apt; Fiscal Year: 2005....
- IBANGS Annual Meeting supportJohn Crabbe; Fiscal Year: 2005..This young society represents an opportunity to attract a core group of young investigators to alcohol research during their formative years. ..
- ANALYZE: Software for Joint Linkage and LD AnalysisJoseph Terwilliger; Fiscal Year: 2005..These programs will be distributed as part of the expanded ANALYZE software package to be developed in this proposed project. ..
- Genome biology of Francisella tularensis populationsAndrew Benson; Fiscal Year: 2005....
- Functional genomics of ethanol craving and naltrexoneMichael Miles; Fiscal Year: 2008..Together, these findings may identify novel targets for therapeutic intervention in alcoholism. ..
- Microarray Analysis of Acute Ethanol Effects in BrainMichael Miles; Fiscal Year: 2003..These findings might generate novel insights for the treatment of alcoholism. ..
- A Genome-wide Association Study for Early-Onset Myocardial InfarctionDavid Altshuler; Fiscal Year: 2009..Successfully identifying common gene variants and novel pathways underlying risk of Ml has the potential to transform understanding, treatment, and prevention of the leading cause of death in the U.S. (End of Abstract) ..
- Comparative Functional Genomics of Drosophila ObesityAndrew Clark; Fiscal Year: 2009..which particular genes and pathways are most relevant to variation in fat storage homeostasis, and by developing a systems biology approach to make inferences from data that span cellular, endocrine, and whole-organism attributes ..
- MOLECULAR CHARACTERIZATION OF ACYL-COA DEHYDROGENASESGerard Vockley; Fiscal Year: 2004..This work will lead to a more complete understanding of the ACD gene family, and ultimately, to an improved ability to diagnose and treat patients with deficiencies of these enzymes. ..
- GENETIC STUDIES OF COMMON CONGENITAL HEART DEFECTSJohn Belmont; Fiscal Year: 2004..The proposed studies will provide a base on which to advance genetic analyses of a substantial group of congenital heart defects with the aim of reducing their occurrence and providing new treatment opportunities. ..