insect genes

Summary

Summary: The functional hereditary units of INSECTS.

Top Publications

  1. ncbi Using FlyAtlas to identify better Drosophila melanogaster models of human disease
    Venkateswara R Chintapalli
    Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, UK
    Nat Genet 39:715-20. 2007
  2. ncbi The genome of the model beetle and pest Tribolium castaneum
    Stephen Richards
    Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 452:949-55. 2008
  3. pmc Genome sequence of Aedes aegypti, a major arbovirus vector
    Vishvanath Nene
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 316:1718-23. 2007
  4. ncbi G protein-coupled receptors in Anopheles gambiae
    Catherine A Hill
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Science 298:176-8. 2002
  5. ncbi Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
  6. ncbi An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    W Brogiolo
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 11:213-21. 2001
  7. ncbi Simultaneous identification of species and molecular forms of the Anopheles gambiae complex by PCR-RFLP
    C Fanello
    London School of Hygiene and Tropical Medicine, London, UK
    Med Vet Entomol 16:461-4. 2002
  8. ncbi A single p450 allele associated with insecticide resistance in Drosophila
    P J Daborn
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Science 297:2253-6. 2002
  9. pmc Novel genes derived from noncoding DNA in Drosophila melanogaster are frequently X-linked and exhibit testis-biased expression
    Mia T Levine
    Center for Population Biology, University of California Davis, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 103:9935-9. 2006
  10. ncbi FlyBase : a database for the Drosophila research community
    Rachel Drysdale
    Department of Genetics, University of Cambridge, Cambridge, UK
    Methods Mol Biol 420:45-59. 2008

Research Grants

  1. SERINE PROTEINASE INHIBITORS IN INSECTS
    Michael Kanost; Fiscal Year: 1993
  2. REGULATION OF CECROPIN AND ATTACIN GENE EXPRESSION
    Peter Dunn; Fiscal Year: 1991
  3. MARINER TRANSPOSONS OF MAMMALS
    Hugh Robertson; Fiscal Year: 2001
  4. Gustatory and olfactory receptors of Anopheles gambiae
    Hugh Robertson; Fiscal Year: 2006
  5. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
  6. NEUROGENETICS OF DROSOPHILA REPRODUCTION
    LESLIE GRIFFITH; Fiscal Year: 2007
  7. Quantitative genomics of sexual dimorphism
    Sergey Nuzhdin; Fiscal Year: 2005
  8. Genetics of Dengue Vector Competence in Aedes aegypti
    William Black; Fiscal Year: 2005
  9. Molecular Neurobiology of Behavioral Rhythms
    Jeffrey Hall; Fiscal Year: 2006
  10. The Role of Odorant Binding Proteins in Anopheline Mosquito Odor Perception
    Marika Walter; Fiscal Year: 2008

Detail Information

Publications326 found, 100 shown here

  1. ncbi Using FlyAtlas to identify better Drosophila melanogaster models of human disease
    Venkateswara R Chintapalli
    Division of Molecular Genetics, University of Glasgow, Glasgow G11 6NU, UK
    Nat Genet 39:715-20. 2007
    ....
  2. ncbi The genome of the model beetle and pest Tribolium castaneum
    Stephen Richards
    Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 452:949-55. 2008
    ..Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control...
  3. pmc Genome sequence of Aedes aegypti, a major arbovirus vector
    Vishvanath Nene
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 316:1718-23. 2007
    ..An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species...
  4. ncbi G protein-coupled receptors in Anopheles gambiae
    Catherine A Hill
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Science 298:176-8. 2002
    ..Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation...
  5. ncbi Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
    ..These may prove to underlie differences in the ecology and behaviour of these diverse species...
  6. ncbi An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    W Brogiolo
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 11:213-21. 2001
    ....
  7. ncbi Simultaneous identification of species and molecular forms of the Anopheles gambiae complex by PCR-RFLP
    C Fanello
    London School of Hygiene and Tropical Medicine, London, UK
    Med Vet Entomol 16:461-4. 2002
    ..This procedure is more efficient, faster and cheaper than those used before, so is recommended for large-scale processing of field-collected larval and adult specimens to be identified in malaria vector studies...
  8. ncbi A single p450 allele associated with insecticide resistance in Drosophila
    P J Daborn
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Science 297:2253-6. 2002
    ..This allele is characterized by the insertion of an Accord transposable element into the 5' end of the Cyp6g1 gene...
  9. pmc Novel genes derived from noncoding DNA in Drosophila melanogaster are frequently X-linked and exhibit testis-biased expression
    Mia T Levine
    Center for Population Biology, University of California Davis, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 103:9935-9. 2006
    ..These data support the idea that these novel genes are derived from ancestral noncoding sequence and that new, favored genes are likely to invade populations under selective pressures relating to male reproduction...
  10. ncbi FlyBase : a database for the Drosophila research community
    Rachel Drysdale
    Department of Genetics, University of Cambridge, Cambridge, UK
    Methods Mol Biol 420:45-59. 2008
    ..This review will introduce the FlyBase web server and query tools...
  11. ncbi The genome sequence of the malaria mosquito Anopheles gambiae
    Robert A Holt
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 298:129-49. 2002
    ..An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect...
  12. ncbi A gene-coexpression network for global discovery of conserved genetic modules
    Joshua M Stuart
    Stanford Medical Informatics, 251 Campus Drive, Medical School Office Building X 215, Stanford, CA 94305 5329, USA
    Science 302:249-55. 2003
    ..By assembling these links into a gene-coexpression network, we found several components that were animal-specific as well as interrelationships between newly evolved and ancient modules...
  13. pmc Gene finding in novel genomes
    Ian Korf
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, UK
    BMC Bioinformatics 5:59. 2004
    ..Computational gene prediction continues to be an important problem, especially for genomes with little experimental data...
  14. ncbi Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
    M van de Wetering
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Cell 88:789-99. 1997
    ..Epistasis analysis positions dTCF downstream of armadillo. The Armadillo-dTCF complex mediates Wingless signaling as a bipartite transcription factor...
  15. pmc Genome-wide analysis of the odorant-binding protein gene family in Drosophila melanogaster
    Daria S Hekmat-Scafe
    Department of Environmental Science, Policy and Management, Division of Insect Biology, University of California, Berkeley, California 94720, USA
    Genome Res 12:1357-69. 2002
    ..The sequence data from this study have been submitted to FlyBase. Annotations for these sequences are available as supplementary material at http://www.genome.org.]..
  16. pmc Evolution in the fast lane: rapidly evolving sex-related genes in Drosophila
    Wilfried Haerty
    Department of Biology, McMaster University, Hamilton, Ontario L8S 4K1, Canada
    Genetics 177:1321-35. 2007
    ..SFP genes also show evidence of lineage-specific gene loss and/or gain. These results bring us closer to understanding the details of the evolutionary dynamics of SRR genes with respect to species divergence...
  17. ncbi Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila
    A Wodarz
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Federal Republic of Germany
    Cell 82:67-76. 1995
    ..Our results suggest that crumbs plays a key role in specifying the apical plasma membrane domain of ectodermal epithelial cells of Drosophila...
  18. ncbi The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    B Lemaitre
    Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Cell 86:973-83. 1996
    ..Antibacterial genes are induced either by a distinct pathway involving the immune deficiency gene (imd) or by combined activation of both imd and dorsoventral pathways...
  19. pmc Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response
    Ingo Zinke
    Institut fur Genetik, Forschungszentrum Karlsruhe, Postfach 3640, D 76021 Karlsruhe, Germany
    EMBO J 21:6162-73. 2002
    ..The current analysis provides a basis for studying the genetic mechanisms underlying nutrient signalling...
  20. ncbi A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac
    Stephen T Thibault
    Exelixis, 170 Harbor Way, South San Francisco, California 94083 0511, USA
    Nat Genet 36:283-7. 2004
    ....
  21. ncbi Genetic control of programmed cell death in Drosophila
    K White
    Howard Hughes Medical Institute, Department of Brain and Cognitive Sciences, Cambridge, MA
    Science 264:677-83. 1994
    ..The reaper gene appears to encode a small peptide that shows no homology to known proteins, and reaper messenger RNA is expressed in cells destined to undergo apoptosis...
  22. ncbi Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene
    L C Ryner
    Department of Biological Sciences, Stanford University, California 94305, USA
    Cell 87:1079-89. 1996
    ....
  23. ncbi An overview of insecticide resistance
    Janet Hemingway
    Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK
    Science 298:96-7. 2002
    ..The Anopheles gambiae genome will enable identification of new resistance genes and will provide new molecular targets for the design of more effective insecticides...
  24. ncbi double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation
    J L Price
    Laboratory of Genetics and National Science Foundation Science and Technology Center for Biological Timing, The Rockefeller University, New York, New York 10021, USA
    Cell 94:83-95. 1998
    ..This would promote a delay between per/tim transcription and PER/TIM complex function, which is essential for molecular rhythmicity...
  25. pmc Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures
    Alexander Stark
    The Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02140, USA
    Nature 450:219-32. 2007
    ..We also study how discovery power scales with the divergence and number of species compared, and we provide general guidelines for comparative studies...
  26. ncbi Evolutionary changes in cis and trans gene regulation
    Patricia J Wittkopp
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 430:85-8. 2004
    ..These data indicate that interspecific expression differences are not caused by select trans-regulatory changes with widespread effects, but rather by many cis-acting changes spread throughout the genome...
  27. ncbi Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase
    T Xu
    Department of Genetics, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Development 121:1053-63. 1995
    ..Mutations in lats cause dramatic overproliferation phenotypes and various developmental defects in both mosaic animals and homozygous mutants...
  28. ncbi A draft sequence for the genome of the domesticated silkworm (Bombyx mori)
    Qingyou Xia
    Southwest Agricultural University, Chongqing Beibei, 400716, China
    Science 306:1937-40. 2004
    ..Our estimated gene count is 18,510, which exceeds the 13,379 genes reported for Drosophila melanogaster. Comparative analyses to fruitfly, mosquito, spider, and butterfly reveal both similarities and differences in gene content...
  29. pmc Chromosomal inversions and the reproductive isolation of species
    M A Noor
    Department of Biological Sciences, Life Sciences Building, Louisiana State University, Baton Rouge, LA 70803, USA
    Proc Natl Acad Sci U S A 98:12084-8. 2001
    ..The maintenance of this sterility allows the species to persist in the face of gene flow longer than without such inversions, and natural selection will have a greater opportunity to decrease the frequency of interspecies matings...
  30. ncbi A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    M Tatar
    Brown University, Providence, RI 02912, USA, University of Massachusetts, Amherst, MA 01003, USA
    Science 292:107-10. 2001
    ....
  31. pmc A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal
    D N Cox
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710 USA
    Genes Dev 12:3715-27. 1998
    ..Decreasing C. elegans piwi expression reduces the proliferation of GSC-equivalent cells. Thus, piwi represents a novel class of genes required for GSC division in diverse organisms...
  32. pmc Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway
    Tatsushi Igaki
    Laboratory for Cell Recovery Mechanisms, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    EMBO J 21:3009-18. 2002
    ..We also show genetically that Eiger is a physiological ligand for the Drosophila JNK pathway. Our findings demonstrate that Eiger can initiate cell death through an IAP-sensitive cell death pathway via JNK signaling...
  33. pmc An evolutionary analysis of orphan genes in Drosophila
    Tomislav Domazet-Loso
    Institut für Genetik der Universität zu Köln, 50931 Koln, Germany
    Genome Res 13:2213-9. 2003
    ..We propose a model suggesting that orphans may be involved in the evolution of adaptive traits, and that slow-evolving orphan genes may be particularly interesting candidate genes for identifying lineage-specific adaptations...
  34. ncbi Pattern formation and eyespot determination in butterfly wings
    S B Carroll
    Howard Hughes Medical Institute, Madison, WI
    Science 265:109-14. 1994
    ..These circular pattern elements appear to be generated by a process similar to, and perhaps evolved from, proximodistal pattern formation in insect appendages...
  35. ncbi Influence of gene action across different time scales on behavior
    Y Ben-Shahar
    Department of Entomology, Neuroscience Program, University of Illinois at Urbana Champaign, 320 Morrill Hall, 505 South Goodwin Avenue, Urbana, IL 61801, USA
    Science 296:741-4. 2002
    ..Previous research showed that allelic differences in PKG expression result in two Drosophila foraging variants. The same gene can thus exert different types of influence on a behavior...
  36. ncbi Activation of Drosophila Toll during fungal infection by a blood serine protease
    Petros Ligoxygakis
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 15 rue R Descartes, F67084 Strasbourg Cedex, France
    Science 297:114-6. 2002
    ..We show that ethylmethane sulfonate-induced mutations in the persephone gene, which encodes a previously unknown serine protease, block induction of the Toll pathway by fungi and resistance to this type of infection...
  37. ncbi Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila
    Christine Kocks
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cell 123:335-46. 2005
    ..Our results suggest that Eater is a major phagocytic receptor for a broad range of bacterial pathogens in Drosophila and provide a powerful model to address the role of phagocytosis in vivo...
  38. ncbi Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila
    Nicholas J Brideau
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Science 314:1292-5. 2006
    ..Rapidly evolving heterochromatic DNA sequences may be driving the evolution of this incompatibility gene...
  39. pmc Ab initio gene finding in Drosophila genomic DNA
    A A Salamov
    The Sanger Centre, Hinxton, Cambridge CB10 1SA, UK
    Genome Res 10:516-22. 2000
    ..The suite of gene identification programs is available through the WWW server of Computational Genomics Group at http://genomic.sanger.ac.uk/gf. html...
  40. pmc MicroRNA targets in Drosophila
    Anton J Enright
    Computational Biology Center, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Genome Biol 5:R1. 2003
    ..Application to the D. melanogaster, Drosophila pseudoobscura and Anopheles gambiae genomes identifies several hundred target genes potentially regulated by one or more known miRNAs...
  41. ncbi Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gambiae associated with resistance to DDT and pyrethroids
    H Ranson
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA
    Insect Mol Biol 9:491-7. 2000
    ..The An. gambiae sodium channel was physically mapped to chromosome 2L, division 20C. This position corresponds to the location of a major quantitative trait locus determining resistance to permethrin in the Kenyan strain of An. gambiae...
  42. ncbi Distinct roles for the actin and microtubule cytoskeletons in the morphogenesis of epidermal hairs during wing development in Drosophila
    C M Turner
    Biology Department and Cancer Center, University of Virginia, Charlottesville 22903, USA
    Mech Dev 70:181-92. 1998
    ..This is a phenocopy of mutations in crinkled, and suggests mutations that cause branched hairs will be in genes that encode products that interact with the actin cytoskeleton...
  43. ncbi Sex-peptides: seminal peptides of the Drosophila male
    E Kubli
    Zoological Institute, University Zurich Irchel, Winterthurerstrasse 190, 8057, Zurich, Switzerland
    Cell Mol Life Sci 60:1689-704. 2003
    ..Sps bind to sperm. Together with sperm they are responsible for the persistence of the two post-mating responses. But Sps are the molecular basis of the sperm effect; sperm is merely the carrier...
  44. pmc DroID: the Drosophila Interactions Database, a comprehensive resource for annotated gene and protein interactions
    Jingkai Yu
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 540 East Canfield Ave, Detroit, MI 48201, USA
    BMC Genomics 9:461. 2008
    ..No single database, for example, includes all available interactions, integrated gene expression data, and comprehensive and searchable gene information for the important model organism, Drosophila melanogaster...
  45. pmc Post-mating gene expression profiles of female Drosophila melanogaster in response to time and to four male accessory gland proteins
    Lisa A McGraw
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genetics 179:1395-408. 2008
    ..In contrast, Acp29AB and Acp62F modulated a large number of transcriptional changes shortly after mating...
  46. ncbi Functional relationships between Notch, Su(H) and the bHLH genes of the E(spl) complex: the E(spl) genes mediate only a subset of Notch activities during imaginal development
    J F de Celis
    Department of Genetics, University of Cambridge, UK
    Development 122:2719-28. 1996
    ..Transcriptional activation mediated by Suppressor of Hairless and transcriptional repression mediated by Enhancer of split could provide greater diversity in the response of individual genes to Notch activity...
  47. pmc Genome wide analysis of common and specific stress responses in adult drosophila melanogaster
    Fabrice Girardot
    Institut Jacques Monod, 2 place Jussieu, 75251 Paris, France
    BMC Genomics 5:74. 2004
    ..In addition, the functional significance of observed transcriptional changes is still elusive...
  48. ncbi Insect P450 enzymes
    R Feyereisen
    Department of Entomology, University of Arizona, Tucson 85721, USA
    Annu Rev Entomol 44:507-33. 1999
    ..Polymorphisms in induction or constitutive expression allow insects to scan their P450 gene repertoire for the appropriate response to chemical insults, and these evolutionary pressures in turn maintain P450 diversity...
  49. pmc The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes
    Hugo J Bellen
    Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genetics 167:761-81. 2004
    ..Finally, the project reveals new insight into how transposons interact with a eukaryotic genome and helps define optimal strategies for using insertional mutagenesis as a genomic tool...
  50. pmc Function and evolution of a gene family encoding odorant binding-like proteins in a social insect, the honey bee (Apis mellifera)
    Sylvain Foret
    Visual Sciences and ARC Centre for the Molecular Genetics of Development, Research School of Biological Sciences, The Australian National University, Canberra ACT 0200, Australia
    Genome Res 16:1404-13. 2006
    ..These findings support the view that OBPs are not restricted to olfaction and are likely to be involved in broader physiological functions...
  51. ncbi Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
    T Michel
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France
    Nature 414:756-9. 2001
    ..Interestingly, seml does not affect Toll activation by fungal infection, indicating the existence of a distinct recognition system for fungi to activate the Toll pathway...
  52. pmc Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells
    L L Wong
    Biology Department, University of Virginia, Charlottesville 22901
    J Cell Biol 123:209-21. 1993
    ..This suggests that the tissue polarity genes function in or on a pathway that controls hair polarity by regulating the subcellular location for prehair formation...
  53. pmc Paucity of genes on the Drosophila X chromosome showing male-biased expression
    Michael Parisi
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892 8028, USA
    Science 299:697-700. 2003
    ..These data indicate that the X chromosome is a disfavored location for genes selectively expressed in males...
  54. ncbi Cell interactions and planar polarity in the abdominal epidermis of Drosophila
    Peter A Lawrence
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 131:4651-64. 2004
    ..However, some results do not fit with this view--we suggest that these localisations may be more a consequence than a cause of planar polarity...
  55. ncbi The TAGteam DNA motif controls the timing of Drosophila pre-blastoderm transcription
    John R ten Bosch
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 3204, USA
    Development 133:1967-77. 2006
    ....
  56. ncbi Intergenomic conflict revealed by patterns of sex-biased gene expression
    Tim Connallon
    Department of Ecology and Evolutionary Biology, Museum of Zoology, University of Michigan, Ann Arbor, MI 48109 1079, USA
    Trends Genet 21:495-9. 2005
    ....
  57. ncbi Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
    D J Clancy
    Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Science 292:104-6. 2001
    ..The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved...
  58. ncbi Drosophila melanogaster mitochondrial DNA: completion of the nucleotide sequence and evolutionary comparisons
    D L Lewis
    Department of Biochemistry, Michigan State University, East Lansing, USA
    Insect Mol Biol 4:263-78. 1995
    ..yakuba mtDNA. All genes encoded in the mtDNA of both species are in identical locations and orientations. Nucleotide substitution analysis reveals that tRNA and rRNA genes evolve at less than half the rate of protein coding genes...
  59. pmc X chromosome inactivation during Drosophila spermatogenesis
    Winfried Hense
    Department of Biology II, University of Munich, Planegg Martinsried, Germany
    PLoS Biol 5:e273. 2007
    ..These results are consistent with global inactivation of the X chromosome in the male germline and support a selective explanation for X chromosome avoidance of genes with beneficial effects late in spermatogenesis...
  60. pmc Comparative genomic analysis of the Tribolium immune system
    Zhen Zou
    Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078, USA
    Genome Biol 8:R177. 2007
    ..We have annotated immunity-related genes and compared them with homologous molecules from other species...
  61. ncbi The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in Drosophila melanogaster
    Reka Albert
    School of Mathematics, University of Minnesota, 127 Vincent Hall, Minneapolis, MN 55455, USA
    J Theor Biol 223:1-18. 2003
    ..The model gives important insights into the functioning of the segment polarity gene network, such as the crucial role of the wingless and sloppy paired genes, and the network's ability to correct errors in the pre-pattern...
  62. pmc Genes required for mitotic spindle assembly in Drosophila S2 cells
    Gohta Goshima
    Howard Hughes Medical Institute and the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA
    Science 316:417-21. 2007
    ..The screen, in combination with a variety of secondary assays, led to new insights into how spindle microtubules are generated; how centrosomes are positioned; and how centrioles, centrosomes, and kinetochores are assembled...
  63. ncbi Sex-dependent gene expression and evolution of the Drosophila transcriptome
    Jose M Ranz
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Science 300:1742-5. 2003
    ..Our results suggest that sex-dependent selection may drive changes in expression of many of the most rapidly evolving genes in the Drosophila transcriptome...
  64. ncbi Adaptive protein evolution in Drosophila
    Nick G C Smith
    Centre for the Study of Evolution and School of Biological Sciences, University of Sussex, Brighton BN1 9QG, UK
    Nature 415:1022-4. 2002
    ..yakuba. We estimate that 45% of all amino-acid substitutions have been fixed by natural selection, and that on average one adaptive substitution occurs every 45 years in these species...
  65. pmc General gene movement off the X chromosome in the Drosophila genus
    Maria D Vibranovski
    Department of Ecology and Evolution, The University of Chicago, Chicago, IL 60637, USA
    Genome Res 19:897-903. 2009
    ..These analyses of both DNA-based and RNA-based gene relocations reveal that the out-of-the-X movement of testis-expressed genes is a general pattern in the Drosophila genus...
  66. ncbi Tribbles coordinates mitosis and morphogenesis in Drosophila by regulating string/CDC25 proteolysis
    J Mata
    Developmental Biology Programme, European Molecular Biology Laboratory, Heidelberg, Germany
    Cell 101:511-22. 2000
    ..By regulating CDC25, Tribbles serves to coordinate entry into mitosis with morphogenesis and cell fate determination...
  67. ncbi The Drosophila takeout gene is a novel molecular link between circadian rhythms and feeding behavior
    L Sarov-Blat
    Howard Hughes Medical Institute, National Science Foundation, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Cell 101:647-56. 2000
    ..We propose that to participates in a novel circadian output pathway that conveys temporal and food status information to feeding-relevant metabolisms and activities...
  68. ncbi Genome-scale profiling of histone H3.3 replacement patterns
    Yoshiko Mito
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nat Genet 37:1090-7. 2005
    ..3 from upstream to downstream of transcription units. We propose that deposition and inheritance of actively modified H3.3 in regulatory regions maintains transcriptionally active chromatin...
  69. ncbi Pesticide resistance via transposition-mediated adaptive gene truncation in Drosophila
    Yael T Aminetzach
    Department of Biological Sciences, Stanford University, 371 Serra Mall, Stanford, CA 94305, USA
    Science 309:764-7. 2005
    ..The insertion of this transposable element confers increased resistance to an organophosphate pesticide and has spread in D. melanogaster recently...
  70. ncbi Identification and expression pattern of the chemosensory protein gene family in the silkworm, Bombyx mori
    Da Ping Gong
    The Key Sericultural Laboratory of Agricultural Ministry, Southwest University, Chongqing 400716, China
    Insect Biochem Mol Biol 37:266-77. 2007
    ..The majority of silkworm CSP genes are expressed broadly in tissues including the antennae, head, thorax, legs, wings, epithelium, testes, ovaries, pheromone glands, wing disks, and compound eyes...
  71. pmc The sex peptide of Drosophila melanogaster: female post-mating responses analyzed by using RNA interference
    Tracey Chapman
    Department of Biology, Darwin Building, and Wolfson Institute for Biomedical Research, Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK
    Proc Natl Acad Sci U S A 100:9923-8. 2003
    ..The prolonged "sperm effect" on female receptivity and egg production is therefore entirely attributable to SP, but sperm are necessary for its occurrence...
  72. ncbi Generation of a widespread Drosophila inversion by a transposable element
    M Caceres
    Departament de Genetica i de Microbiologia, Universitat Autonoma de Barcelona, 08193 Bellaterra Barcelona, Spain
    Science 285:415-8. 1999
    ..This is apparently the mechanism by which transposable elements generate natural inversions in Drosophila...
  73. pmc The anterior determinant bicoid of Drosophila is a derived Hox class 3 gene
    M Stauber
    Max Planck Institut fur biophysikalische Chemie, Abteilung Molekulare Entwicklungsbiologie, Am Fassberg 11, D 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 96:3786-9. 1999
    ....
  74. ncbi The birth and death of microRNA genes in Drosophila
    Jian Lu
    Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, Illinois 60637, USA
    Nat Genet 40:351-5. 2008
    ..The estimated net gain of long-lived miRNA genes, which is not strongly affected by either the depth or the breadth (number of tissues) of sequencing, is 0.3 genes per Myr in Drosophila...
  75. ncbi Noncoding RNAs of trithorax response elements recruit Drosophila Ash1 to Ultrabithorax
    Tilman Sanchez-Elsner
    Department of Biochemistry, University of California, Riverside, CA 92521, USA
    Science 311:1118-23. 2006
    ..Small interfering RNA-induced degradation of TRE transcripts attenuates Ash1 recruitment to TREs and Ubx expression, which suggests that noncoding TRE transcripts play an important role in epigenetic activation of gene expression...
  76. pmc High-resolution mapping reveals links of HP1 with active and inactive chromatin components
    Elzo de Wit
    Department of Molecular Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    PLoS Genet 3:e38. 2007
    ..These results demonstrate that HP1-chromatin is transcriptionally active and has extensive links with several other chromatin components...
  77. pmc High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome
    Artyom A Alekseyenko
    Howard Hughes Medical Institute, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Genes Dev 20:848-57. 2006
    ..Distinguishing expressed genes from the bulk of the genome is likely to be an important function common to many chromatin organizing and modifying activities...
  78. pmc Genomic and functional studies of Drosophila sex hierarchy regulated gene expression in adult head and nervous system tissues
    Thomas D Goldman
    Section of Molecular and Computational Biology, Department of Biological Sciences, University of Southern California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 3:e216. 2007
    ..We show that dpr and dpr-expressing cells are required for the proper timing of male courtship behaviors...
  79. pmc Linkage of butterfly mate preference and wing color preference cue at the genomic location of wingless
    Marcus R Kronforst
    Section of Integrative Biology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:6575-80. 2006
    ..This effect of linkage on divergence is especially important in Heliconius because differentiation of wing color patterns in the genus has been driven and maintained by natural selection for Müllerian mimicry...
  80. pmc The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
    Martin A Jünger
    Zoologisches Institut, Universitat Zurich, Winterthurerstr, 190, CH 8057 Zurich, Switzerland
    J Biol 2:20. 2003
    ..In this study, we present a genetic characterization of dFOXO, the only Drosophila FOXO ortholog...
  81. pmc Retroposed new genes out of the X in Drosophila
    ESTHER BETRAN
    Department of Ecology and Evolution, The University of Chicago, Chicago, Illinois 60637, USA
    Genome Res 12:1854-9. 2002
    ..These observations may be explained by natural selection favoring those new retrogenes that moved to autosomes and avoided the spermatogenesis X inactivation, and suggest the important role of genome position for the origin of new genes...
  82. ncbi Patterns of gene expression during Drosophila mesoderm development
    E E Furlong
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, Stanford University School of Medicine, Stanford, CA 94305-5329, USA
    Science 293:1629-33. 2001
    ..One such gene, gleeful, related to the vertebrate Gli genes, is essential for somatic muscle development and sufficient to cause neural cells to express a muscle marker...
  83. pmc Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster
    Huanfa Liu
    Zoological Institute, University of Zurich Irchel, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 100:9929-33. 2003
    ..The second conclusion is supported by the finding that SP binds to sperm. The 36-aa-encoding SP gene is the first small Drosophila gene knocked out with the method of homologous recombination...
  84. pmc Kakapo, a novel cytoskeletal-associated protein is essential for the restricted localization of the neuregulin-like factor, vein, at the muscle-tendon junction site
    D Strumpf
    Department of Molecular Genetics, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Cell Biol 143:1259-70. 1998
    ..This may lead to aberrant differentiation of tendon cells and consequently to the kakapo mutant deranged somatic muscle phenotype...
  85. ncbi Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death
    B A Hay
    Howard Hughes Medical Institute, University of California, Berkeley 94720 3200, USA
    Cell 83:1253-62. 1995
    ..IAP death-preventing activity localizes to the N-terminal baculovirus IAP repeats, a motif found in both viral and cellular proteins associated with death prevention...
  86. pmc A gene-based linkage map for Bicyclus anynana butterflies allows for a comprehensive analysis of synteny with the lepidopteran reference genome
    Patricia Beldade
    Institute of Biology, Leiden University, Leiden, The Netherlands
    PLoS Genet 5:e1000366. 2009
    ..This is discussed in relation to the identification of the loci contributing to color pattern evolution in butterflies...
  87. ncbi Activation of transcription in Drosophila embryos is a gradual process mediated by the nucleocytoplasmic ratio
    D K Pritchard
    Department of Genetics, University of Washington, Seattle, Washington, USA
    Genes Dev 10:1131-42. 1996
    ....
  88. ncbi A spatial map of olfactory receptor expression in the Drosophila antenna
    L B Vosshall
    Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, New York, New York 10032, USA
    Cell 96:725-36. 1999
    ..The isolation of candidate odorant receptor genes along with a genetic analysis of olfactory-driven behavior in insects may ultimately afford a system to understand the mechanistic link between odor recognition and behavior...
  89. ncbi Activation of a meiotic checkpoint during Drosophila oogenesis regulates the translation of Gurken through Chk2/Mnk
    Uri Abdu
    HHMI, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Curr Biol 12:1645-51. 2002
    ..However, the components of this checkpoint in flies have not been completely elucidated...
  90. ncbi CYCLE is a second bHLH-PAS clock protein essential for circadian rhythmicity and transcription of Drosophila period and timeless
    J E Rutila
    NSF, Center for Biological Timing, and Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    Cell 93:805-14. 1998
    ..We propose that the CYC:CLK heterodimer binds to per and tim E boxes and makes a major contribution to the circadian transcription of Drosophila clock genes...
  91. ncbi Reduced adaptation of a non-recombining neo-Y chromosome
    Doris Bachtrog
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Nature 416:323-6. 2002
    ..Our results provide evidence for the importance of sexual recombination for increasing and maintaining the level of adaptation of a population...
  92. pmc pavarotti encodes a kinesin-like protein required to organize the central spindle and contractile ring for cytokinesis
    R R Adams
    Cancer Research Campaign CRC Laboratories, Cell Cycle Genetics Research Group, Department of Anatomy and Physiology, Medical Sciences Institute, University of Dundee, Dundee DD1 4HN, UK
    Genes Dev 12:1483-94. 1998
    ..We suggest that PAV-KLP is required both to establish the structure of the telophase spindle to provide a framework for the assembly of the contractile ring, and to mobilize mitotic regulator proteins...
  93. ncbi Expression of achaete-scute homologues in discrete proneural clusters on the developing notum of the medfly Ceratitis capitata, suggests a common origin for the stereotyped bristle patterns of higher Diptera
    C Wülbeck
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France
    Development 127:1411-20. 2000
    ..Some aspects of the transcriptional regulation have changed, however, and correlate in the notum with differences in the bristle pattern. The Ceratitis pannier gene was isolated and displays a conserved expression domain in the notum...
  94. ncbi The even-skipped locus is contained in a 16-kb chromatin domain
    C Sackerson
    Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA
    Dev Biol 211:39-52. 1999
    ..4) Expression in different sites in the central nervous system is driven by separable elements widely dispersed throughout 8 kb 3' of the gene...
  95. ncbi Developmental expression of Manduca shade, the P450 mediating the final step in molting hormone synthesis
    Kim F Rewitz
    Department of Life Sciences and Chemistry, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
    Mol Cell Endocrinol 247:166-74. 2006
    ..The data suggest that precise tissue-specific transcriptional regulation controls the levels, and thereby the activity, of the Manduca E20MO...
  96. ncbi Drosophila bunched integrates opposing DPP and EGF signals to set the operculum boundary
    L L Dobens
    Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Development 127:745-54. 2000
    ..Thus, the balance of DPP and EGF signals sets the boundary of bunched expression. We propose that the juxtaposition of cells with high and low BUNCHED activity organizes a sharp boundary for the operculum fate...
  97. pmc Gene family evolution across 12 Drosophila genomes
    Matthew W Hahn
    Department of Biology, Indiana University, Bloomington, Indiana, United States of America
    PLoS Genet 3:e197. 2007
    ..It is likely that this genomic revolving door has played a large role in shaping the morphological, physiological, and metabolic differences among species...
  98. pmc Mutations in many genes affect aggressive behavior in Drosophila melanogaster
    Alexis C Edwards
    Department of Genetics, North Carolina State University, Raleigh, NC, USA
    BMC Biol 7:29. 2009
    ..Here, we present the results of a screen of 170 Drosophila P-element insertional mutations for quantitative differences in aggressive behavior from their co-isogenic control line...
  99. ncbi The stoned proteins regulate synaptic vesicle recycling in the presynaptic terminal
    T Fergestad
    Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA
    J Neurosci 19:5847-60. 1999
    ..These results suggest that the stoned proteins are essential for the recycling of synaptic vesicle membrane and are required for the proper sorting of synaptotagmin during endocytosis...
  100. ncbi The Drosophila disembodied gene controls late embryonic morphogenesis and codes for a cytochrome P450 enzyme that regulates embryonic ecdysone levels
    V M Chavez
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Development 127:4115-26. 2000
    ....
  101. pmc Painting of fourth, a chromosome-specific protein in Drosophila
    J Larsson
    Department of Microbiology, Umea University, S 901 87 Umea, Sweden
    Proc Natl Acad Sci U S A 98:6273-8. 2001
    ..In the related species Drosophila busckii, POF paints the entire X chromosome exclusively in males, suggesting relationships between the fourth chromosome and the X and between POF complexes and dosage-compensation complexes...

Research Grants69

  1. SERINE PROTEINASE INHIBITORS IN INSECTS
    Michael Kanost; Fiscal Year: 1993
    ..Furthermore, the study of insect serpin genes will generate new information on regulation of insect genes during development.
  2. REGULATION OF CECROPIN AND ATTACIN GENE EXPRESSION
    Peter Dunn; Fiscal Year: 1991
    ..will yield new information concerning (i) the insect host-pathogen/parasite interaction and (ii) the structure and regulation of insect genes. This knowledge may contribute to the management of insect vectors of human and animal disease.
  3. MARINER TRANSPOSONS OF MAMMALS
    Hugh Robertson; Fiscal Year: 2001
    ..It will also reveal how occasionally particular copies of transposons can become integral parts of their host genetic complements. ..
  4. Gustatory and olfactory receptors of Anopheles gambiae
    Hugh Robertson; Fiscal Year: 2006
    ..This work will also contribute to our overall understanding of the molecular basis of chemoreception in insects and other animals. [unreadable] [unreadable]..
  5. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
    ....
  6. NEUROGENETICS OF DROSOPHILA REPRODUCTION
    LESLIE GRIFFITH; Fiscal Year: 2007
    ..melanogaster ..
  7. Quantitative genomics of sexual dimorphism
    Sergey Nuzhdin; Fiscal Year: 2005
    ..We expect our results to have a profound impact on our understanding of the evolution of sexual dimorphism, and the role that sexual differentiation plays in the generation of phenotypic diversity. ..
  8. Genetics of Dengue Vector Competence in Aedes aegypti
    William Black; Fiscal Year: 2005
    ..DS2 and DR2 will be used in the construction of recombinant inbred lines for use in a subtractive hybridization approach to clone cDNAs putatively encoded bydmib3and to assist in a collaborative effort to positionally clone dmib3. ..
  9. Molecular Neurobiology of Behavioral Rhythms
    Jeffrey Hall; Fiscal Year: 2006
    ..of chronobiology in this model system may provide insights into the nature of certain rhythm-related disorders of humans, some of which are associated with genetic variations of Drosophila clock gene orthologs [unreadable] [unreadable]..
  10. The Role of Odorant Binding Proteins in Anopheline Mosquito Odor Perception
    Marika Walter; Fiscal Year: 2008
    ..abstract_text> ..
  11. Ecology, genetics and physiology of insect vectors
    Elliot Krafsur; Fiscal Year: 2006
    ..abstract_text> ..
  12. Natural variation in Drosophila female postmating traits
    DAVID BEGUN; Fiscal Year: 2008
    ..abstract_text> ..
  13. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2006
    ....
  14. Molecular Genetic Analysis of Neurodegeneration
    Nancy Bonini; Fiscal Year: 2007
    ....
  15. METABOLIC CONTROL AND MOLECULAR ADAPTATION IN DROSOPHILA
    WALTER EANES; Fiscal Year: 2005
    ..Studies will begin to identify the genes responsible for the variation in this suite of traits that have cascading effects into the metabolic pathways. ..
  16. Noncoding RNAs and Chromatin Structure
    Richard Kelley; Fiscal Year: 2007
    ..A new model to explain how cis spreading operates will be tested. New search methods will be developed to identify currently unknown noncoding RNAs. [unreadable] [unreadable]..
  17. Evolutionary genomics of new Drosophila genes
    DAVEN PRESGRAVES; Fiscal Year: 2004
    ..The methods developed will be applicable in comparative analysis of other genomes, including those of humans and their primate relatives. ..
  18. ACTIVITY OF THE ALZHEIMERS DISEASE PRESENIL IN PROTEIN
    Nancy Bonini; Fiscal Year: 2004
    ..The studies proposed here will clarify the biochemical activity of Presenilin in the processing of Notch, APP and other proteins, and may ultimately increase our understanding of the molecular causes of Alzheimer's disease. ..
  19. A Drosophilia Model of Amyotrophic Lateral Schlerosis
    Stephen Jackson; Fiscal Year: 2004
    ..Results from this work should clarify the normal cellular role of the ALS2 gene and may reveal strategies for treatment of ALS disease. ..
  20. Population genetics of transgenes in mosquito vectors
    Fred Gould; Fiscal Year: 2008
    ..A user-friendly form of the models as well as an accessible manual will be developed and placed on the internet. ..
  21. Molecular genetics of egg activation and pronuclear function in Drosophila
    MARIANA FEDERICA WOLFNER; Fiscal Year: 2010
    ..Thus, we exploit the powerful genetics of Drosophila to elucidate efficiently the molecules and gene pathways needed to start development in humans. ..
  22. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    Brian P Lazzaro; Fiscal Year: 2010
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
  23. Human Population Genomics
    Andrew Kern; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  24. Biology of Serine Proteases and Serpins
    Carl Hashimoto; Fiscal Year: 2010
    ..abstract_text> ..
  25. Regulatory systems of Drosophila aging
    Marc Tatar; Fiscal Year: 2007
    ..In a comprehensive experimental design, we shall assess qualifies of stress resistance, central metabolism and mitochondria function to determine which feature best predicts variance in life span [unreadable] [unreadable]..
  26. Functions and Interactions dFOXO in Drosopila Aging
    Marc Tatar; Fiscal Year: 2010
    ....
  27. Mathematical Modeling - Biochemical Networks in Yeast
    Reinhard Laubenbacher; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  28. Juvenile Hormone Receptor in Flies and Mosquitoes
    Thomas Wilson; Fiscal Year: 2007
    ..In addition, a better understanding of Met as a bHLH-PAS gene will further our knowledge of this family of transcriptional regulators, including homologous genes found in humans. [unreadable] [unreadable]..
  29. Molecular Genetics of Dengue Resistance in Mosquitoes
    David Severson; Fiscal Year: 2008
    ..abstract_text> ..
  30. CADDMR: a Cell-based Assay for Drug Discovery for Mental Retardation Disorders
    LINDA RESTIFO; Fiscal Year: 2007
    ..The proposed experiments are an important step toward that goal. [unreadable] [unreadable] [unreadable]..
  31. Genetics of Reproductive Senescence
    Marc Tatar; Fiscal Year: 2010
    ..Coupled with the program-wide multidimensional measures of somatic aging, we shall evaluate the extent that reproductive and somatic aging are concordant or independent. ..
  32. Muscarinic regulation of plasticity in the brain
    Gene Robinson; Fiscal Year: 2009
    ..Our results will also suggest directions for the development of treatments for the decline in mental function that accompanies human aging. ..
  33. Regulation of Stable Fat Loss in a Model System
    Gene E Robinson; Fiscal Year: 2010
    ..The goal of this proposal is to use genomic and systems biology techniques to identify "switch" genes that enable stable weight loss in the bee, and to test that these genes regulate body weight and energy metabolism in mammals. ..
  34. Genetic Analysis of Olfactory Coding in Drosophilia
    LESLIE VOSSHALL; Fiscal Year: 2009
    ..The health relatedness of these studies is that an understanding of circuits underlying sensory perception is relevant for brain disorders with a neurological or psychiatric basis. ..
  35. Transcriptional and genic basis of incipient speciation
    Chung I Wu; Fiscal Year: 2008
    ..We expect to identify a number of candidate "speciation genes,* and will carry out precise gene replacement (Rong and Golic 2000; Greenberg et al. 2003) to confirm their effects on the mating behavior. ..
  36. The Mechanisms and Regulatory Networks of Alternative Splicing in Drosophila
    BRENTON GRAVELEY; Fiscal Year: 2009
    ....
  37. SCF complex and the Drosophila centrosome cycle
    EDWARD JOHN WOJCIK; Fiscal Year: 2010
    ..These discoveries will provide new diagnostic or therapeutic targets for the prevention or treatment of cancer. ..
  38. REGULATION OF NEUROGENESIS IN THE DROSOPHILA CNS
    Krishna Bhat; Fiscal Year: 2002
    ..These studies will help understand pathways that govern the lineage elaboration in the Drosophila CNS as well as in other eukaryotic organisms including humans. ..
  39. A Drosophila model of Batten Disease
    Robert Glaser; Fiscal Year: 2004
    ..The specific aims of the proposal are: 1. Determine the phenotypic consequences of removing DmPPT1 function by gene mutation. 2. Determine the phenotypic consequences of disrupting DmPPT1 function by RNA interference. ..
  40. STEROID REGULATION OF PROGRAMMED CELL DEATH
    CARL THUMMEL; Fiscal Year: 2003
    ..In addition, this study will provide insight into the molecular mechanisms by which systemic hormonal signals are refined into stage- and tissue-specific biological responses during development. ..
  41. NOVEL NF KAPPA B ACTIVATING GENE INVOLVED IN CANCER
    Gabriel Nunez; Fiscal Year: 2004
    ..The experiments outlined in this application should provide important insight into the physiological role of CIPER in cellular processes and the mechanism by which it promotes cancer development. ..
  42. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
    ....
  43. Novel Genes Involved in Drug Response
    Ruthann Nichols; Fiscal Year: 2002
    ..Ultimately, our research will determine the role of these gene products in mediating the effect of nicotine in humans. ..
  44. MOLECULAR ANALYSIS IN ALAGILLE SYNDROME
    Ian Krantz; Fiscal Year: 2002
    ....
  45. MAPPING AND CLONING TRANSLOCATION BREAKPOINTS
    Janet Rowley; Fiscal Year: 2004
    ..In the future, when we have sufficient understanding of the biology of these genes, we can hope to develop genotypic specific treatment. ..
  46. CALCIUM SIGNALING IN THE TESTIS
    KATHLEEN BECKINGHAM; Fiscal Year: 2004
    ..The Androcam homologs in other species will also be isolated with a particular view to pursuing studies of Androcam-related proteins in mammalian species. ..
  47. Genetic Manipulation of Insects
    DAVID O BROCHTA; Fiscal Year: 2004
    ..The meeting is an uncommon opportunity for graduate students and postdoctoral fellows to obtain a high level synopsis of the field of insect molecular genetics and to make important career-advancing interactions. ..
  48. SOCIAL AND NEUROENDOCRINE REGULATION OF THE PERIOD GENE
    Gene Robinson; Fiscal Year: 2002
    ..abstract_text> ..
  49. STAGE and FAIRE for Regulatory Element Identification
    Vishwanath Iyer; Fiscal Year: 2006
    ..abstract_text> ..
  50. Comparative Genomics of Anopheline Mosquitoes
    Zhijian Tu; Fiscal Year: 2006
    ....
  51. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
    ..Obtaining genetic confirmation of the importance of these putative Wnt signaling components will provide the confidence to pursue their study in the context of cancer biology and as targets for drug discovery. ..
  52. Roles of Oct4 dimers during mouse germline development
    Michael Atchison; Fiscal Year: 2006
    ..The anticipated results will have relevant applicability to stem cell and germline biology and lead to a better understanding of human reproduction. ..
  53. Molecular Mechanisms of Drosophila Gonad Morphogenesis
    Mark Van Doren; Fiscal Year: 2005
    ..The completion of these aims will provide the first comprehensive analysis of gonad morphogenesis in Drosophila and provide insight into the molecular mechanisms that control this process. ..
  54. Gravitaxic behavior in Drosophila
    KATHLEEN BECKINGHAM; Fiscal Year: 2003
    ..are used to sense gravity? iii) What role does light play in modulating gravitaxic responses? iv) What molecular signaling pathways are used in the processing of gravitational information in the peripheral and central nervous systems? ..
  55. Molecular Mechanisms of Segmentation
    Cordelia Rauskolb; Fiscal Year: 2005
    ..abstract_text> ..
  56. Eye Development: Molecular Genetics of Nuclear Migration
    Janice Fischer; Fiscal Year: 2005
    ..Finally, a variety of different genetic screening approaches will be used to identify additional genes in the klarsicht/egk1 pathway. ..
  57. POLYMORPHISM/DIVERGENCE IN DROSOPHILA PATHOGEN DEFENSES
    Andrew Clark; Fiscal Year: 2002
    ....
  58. RNAi as a modulator of arbovirus vector competence in transgenic Aedes aegypti
    ALEXANDER WILLIAM EDUARD FRANZ; Fiscal Year: 2010
    ..aegypti when they are not controlled by the mosquito's RNAi response. The proposed research will help to reveal the impact of RNAi as an antiviral defense mechanism in the midgut of Ae. aegypti. ..
  59. Molecular Characterization of Parthenogenetic Meiosis
    DAYALAN SRINIVASAN; Fiscal Year: 2008
    ..These experiments represent the first step toward a molecular characterization of a dramatic example of adaptive plasticity in an ancient, highly conserved process. ..
  60. Mosquito-malaria interactions in the hemocoel
    JULIAN HILLYER; Fiscal Year: 2007
    ..Understanding the mechanisms used by parasites to complete their life cycle inside the vector, and the mechanisms used by the vector to kill parasites, may lead to novel transmission control strategies. [unreadable] [unreadable]..
  61. Cellular Immune Response of Mosquitoes to Pathogens
    JULIAN HILLYER; Fiscal Year: 2003
    ..In understanding the immune response mounted by different insect species and strains toward pathogens, it may be possible to manipulate existing vectors to make the parasite/vector biologic interplay incompatible. ..
  62. Genome wide analysis and modeling of signal integration in the Drosophila ovary
    Stanislav Shvartsman; Fiscal Year: 2009
    ..Given the highly conserved nature of these signaling pathways, our results will provide quantitative insights into the mechanisms of signaling crosstalk in developing and adult tissues. ..
  63. QUANTITATIVE TRAIT LOCI RELATED TO DROSOPHILA SPECIATION
    Sergey Nuzhdin; Fiscal Year: 2004
    ..This comprehensive assessment of the genetics of several traits will further our understanding of the genetics of speciation. ..
  64. Virus-host interactions in replication complex assembly
    David Miller; Fiscal Year: 2009
    ..abstract_text> ..
  65. The Impact of Innate Neuronal Immunity on Neurotropic Arbovirus Pathogenesis
    David Miller; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  66. INTERACTION OF TSETSE--ITS SYMBIONTS AND TRYPANOSOMES
    Serap Aksoy; Fiscal Year: 2001
    ..The basic knowledge obtained will strengthen our understanding of tsetse biology and will also provide information relevant to other important disease vectors which harbor similar symbionts (e.g., ticks, fleas, reduviid bugs etc.). ..
  67. MSM: CR Multiscale analysis of epithelial patterning: m*
    Stanislav Shvartsman; Fiscal Year: 2007
    ..The project will bring together researchers in biology, engineering and mathematics in an interdisciplinary research program aimed at bringing about new understanding of EGFR system. ..
  68. Trypanosome gene expression in tsetse
    Serap Aksoy; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..