Genomes and Genes
Summary: The functional hereditary units of HELMINTHS.
Publications258 found, 100 shown here
- Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegansA Fire
Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
Nature 391:806-11. 1998....
- Systematic functional analysis of the Caenorhabditis elegans genome using RNAiRavi S Kamath
Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Nature 421:231-7. 2003..Our resulting data set and reusable RNAi library of 16,757 bacterial clones will facilitate systematic analyses of the connections among gene sequence, chromosomal location and gene function in C. elegans...
- Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegansColeen T Murphy
Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
Nature 424:277-83. 2003....
- daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegansK D Kimura
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Science 277:942-6. 1997..Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity...
- Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegansR S Kamath
Wellcome CRC Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK
Genome Biol 2:RESEARCH0002. 2001....
- The genome of the blood fluke Schistosoma mansoniMatthew Berriman
Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK
Nature 460:352-8. 2009..The information generated provides an invaluable resource for the research community to develop much needed new control tools for the treatment and eradication of this important and neglected disease...
- Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timingA Grishok
Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell 106:23-34. 2001..Our findings suggest that a common processing machinery generates guide RNAs that mediate both RNAi and endogenous gene regulation...
- Autophagy genes are essential for dauer development and life-span extension in C. elegansAlicia Melendez
Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
Science 301:1387-91. 2003..elegans orthologs of the yeast autophagy genes APG1, APG7, APG8, and AUT10. Thus, autophagy is a cellular pathway essential for dauer development and life-span extension in C. elegans...
- A gene-coexpression network for global discovery of conserved genetic modulesJoshua M Stuart
Stanford Medical Informatics, 251 Campus Drive, Medical School Office Building X 215, Stanford, CA 94305 5329, USA
Science 302:249-55. 2003..By assembling these links into a gene-coexpression network, we found several components that were animal-specific as well as interrelationships between newly evolved and ancient modules...
- Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegansB Wightman
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
Cell 75:855-62. 1993..These data suggest a molecular mechanism for Lin-14p temporal gradient formation: the lin-4 RNAs base pair to sites in the lin-14 3'UTR to form multiple RNA duplexes that down-regulate lin-14 translation...
- A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegansS W Knight
Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, 50 North Medical Drive, Room 211, Salt Lake City, UT 84132, USA
Science 293:2269-71. 2001..Mutant animals have germ line defects that lead to sterility, suggesting that cleavage of dsRNA to short pieces is a requisite event in normal development...
- A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunityDennis H Kim
Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
Science 297:623-6. 2002..These data suggest that this MAP kinase signaling cassette represents an ancient feature of innate immune responses in evolutionarily diverse species...
- Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitationSeung Wook Oh
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nat Genet 38:251-7. 2006..We also demonstrate that DAF-16 is recruited to multiple promoters to coordinate regulation of its downstream targets. The large number of target genes discovered provides insight into how DAF-16 controls diverse biological functions...
- The genetics of feeding in Caenorhabditis elegansL Avery
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9038
Genetics 133:897-917. 1993..eat-6 and eat-12 mutants failed to relax their pharyngeal muscles properly. These pharyngeal motion defects are most easily explained as resulting from abnormal electrical excitability of the pharyngeal muscle membrane...
- The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factorF J Slack
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
Mol Cell 5:659-69. 2000..We suggest that late larval activation of let-7 RNA expression downregulates LIN-41 to relieve inhibition of lin-29...
- Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegansB Sönnichsen
Cenix BioScience GmbH, Tatzberg 47 51, D 01307 Dresden, Germany
Nature 434:462-9. 2005....
- SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2AKirk R Anders
Department of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
EMBO J 22:641-50. 2003..Our results suggest that PP2A is the SMG-2 phosphatase, and the role of SMG-5 is to direct PP2A to its SMG-2 substrate. We discuss cycles of SMG-2 phosphorylation and their roles in NMD...
- Regulation of life-span by germ-line stem cells in Caenorhabditis elegansNuno Arantes-Oliveira
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143 0448, USA
Science 295:502-5. 2002..We propose that the germ-line stem cells affect life-span by influencing the production of, or the response to, a steroid hormone that promotes longevity...
- Collagens, modifying enzymes and their mutations in humans, flies and wormsJohanna Myllyharju
Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, FIN 90014 Oulu, Finland
Trends Genet 20:33-43. 2004..elegans mutants are also available to analyse the collagen gene family and their modifying enzymes...
- p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegansEmily R Troemel
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 2:e183. 2006..The contribution of the PMK-1 pathway to the enhanced lifespan of daf-2 mutants suggests that innate immunity is an important determinant of longevity...
- The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9B Conradt
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Cell 93:519-29. 1998..We propose that EGL-1 activates programmed cell death by binding to and directly inhibiting the activity of CED-9, perhaps by releasing the cell death activator CED-4 from a CED-9/CED-4-containing protein complex...
- Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutantsDuo Wang
Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 436:593-7. 2005..These findings suggest that mutations in Rb pathway components cause cells to revert to patterns of gene expression normally restricted to germ cells. Rb may act by a similar mechanism to transform mammalian cells...
- The genetics of caloric restriction in Caenorhabditis elegansB Lakowski
Department of Biology, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec, Canada H3A 1B1
Proc Natl Acad Sci U S A 95:13091-6. 1998..In contrast, we find that food restriction does not further increase the life span of long-lived clk-1 mutants, suggesting that clk-1 and caloric restriction affect similar processes...
- Genes required for GABA function in Caenorhabditis elegansS L McIntire
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
Nature 364:334-7. 1993..Some of these genes are likely to encode previously unidentified proteins required for GABA function...
- Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistanceW B Derry
Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
Science 294:591-5. 2001..These findings show that C. elegans p53 mediates multiple stress responses in the soma, and mediates apoptosis and meiotic chromosome segregation in the germ line...
- Lifespan regulation by evolutionarily conserved genes essential for viabilitySean P Curran
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
PLoS Genet 3:e56. 2007..These results suggest that insulin-signaling pathways play a role in regulation of aging at any stage in life...
- Roles for 147 embryonic lethal genes on C.elegans chromosome I identified by RNA interference and video microscopyP Zipperlen
University of Cambridge, Wellcome CRC Institute and Department of Genetics, Tennis Court Road, Cambridge CB2 1QR, UK
EMBO J 20:3984-92. 2001....
- Stochastic and genetic factors influence tissue-specific decline in ageing C. elegansLaura A Herndon
Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, A232 Nelson Biological Laboratories, 604 Allison Road, Piscataway, New Jersey 08854, USA
Nature 419:808-14. 2002..Strikingly, we found strong evidence that stochastic as well as genetic factors are significant in C. elegans ageing, with extensive variability both among same-age animals and between cells of the same type within individuals...
- Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCRKatie L Styer
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
Science 322:460-4. 2008..elegans, suggesting that GPCRs may participate in neural circuits that receive inputs from either pathogens or infected sites and integrate them to coordinate appropriate immune responses...
- Quantitative evidence for conserved longevity pathways between divergent eukaryotic speciesErica D Smith
Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
Genome Res 18:564-70. 2008..Together, these findings indicate that the genetic component of life span determination is significantly conserved between divergent eukaryotic species, and suggest pathways that are likely to play a similar role in mammalian aging...
- Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genesKaveh Ashrafi
Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Nature 421:268-72. 2003....
- The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegansB J Reinhart
Department of Molecular Biology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
Nature 403:901-6. 2000..We propose that the sequential stage-specific expression of the lin-4 and let-7 regulatory RNAs triggers transitions in the complement of heterochronic regulatory proteins to coordinate developmental timing...
- Pod-2, along with pod-1, defines a new class of genes required for polarity in the early Caenorhabditis elegans embryoA Tagawa
Division of Biology, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA
Dev Biol 233:412-24. 2001..Our data suggest that pod-2 may be required to properly position an a-p polarity cue...
- A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegansKirthi C Reddy
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 323:382-4. 2009..For C. elegans, bacteria represent food but also a potential source of infection. Our data underscore the importance of behavioral responses to oxygen levels in finding an optimal balance between these potentially conflicting cues...
- The versatile worm: genetic and genomic resources for Caenorhabditis elegans researchIgor Antoshechkin
Division of Biology 156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
Nat Rev Genet 8:518-32. 2007..We also hope that it will be helpful in identifying new research opportunities and will promote the development of additional resources...
- A correlation between host-mediated expression of parasite genes as tandem inverted repeats and abrogation of development of female Heterodera glycines cyst formation during infection of Glycine maxVincent P Klink
Department of Biological Sciences, Mississippi State University, Harned Hall, Rm 310, Mississippi State, MS 39762, USA
Planta 230:53-71. 2009..The effect resembles RNA interference. The methodology has been used here as an alternative approach to engineer resistance to H. glycines...
- Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryosC E Rocheleau
Department of Cell Biology, Program in Molecular Medicine, University of Massachusetts Cancer Center, Worcester 01605, USA
Cell 90:707-16. 1997..We present evidence that there may be partially redundant inputs into endoderm specification and that a subset of these genes appear also to function in determining cytoskeletal polarity in certain early blastomeres...
- Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functionsFemke Simmer
Hubrecht Laboratory, Centre for Biomedical Genetics, Utrecht, The Netherlands
PLoS Biol 1:E12. 2003..elegans genome. The resulting dataset will be valuable in conjunction with other functional genomics approaches, as well as in other model organisms...
- MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryosB W Draper
Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cell 87:205-16. 1996..We propose that MEX-3 contributes to anterior-posterior asymmetry by regulating one or more mRNAs involved in specifying the fate of the posterior blastomere...
- Enzymes involved in the biogenesis of the nematode cuticleAntony P Page
Wellcome Centre for Molecular Parasitology, The Anderson College, The University of Glasgow, Glasgow G11 6NU, UK
Adv Parasitol 53:85-148. 2003..This model system will be the main focus of this review...
- eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynxJames P McKay
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
Genetics 166:161-9. 2004..In eat-18 mutants, the gross localization of EAT-2 at the MC synapse is normal, suggesting that it is not required for trafficking. These data indicate that eat-18 could be a novel component of the pharyngeal nicotinic receptor...
- The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migrationB Wightman
Department of Molecular and Cell Biology, University of California, Berkeley, 94720 3204, USA
Development 122:671-82. 1996..vab-8 encodes two genetic activities that function in the guidance of different migrations. Our results suggest that most posteriorly directed cell and growth cone migrations are guided by a common mechanism involving the vab-8 gene...
- A genetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23Nehal Mehta
Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
Genetics 166:1253-67. 2004..We have thus defined separable activities of LIN-23 in two distinct processes, cell cycle control and axon patterning. We propose that LIN-23 targets distinct substrates for ubiquitination within each process...
- Longevity determined by developmental arrest genes in Caenorhabditis elegansDi Chen
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Aging Cell 6:525-33. 2007..We have isolated novel lifespan-extension genes, which may help understand the intrinsic link between organism development and adult lifespan...
- Cellulose binding protein from the parasitic nematode Heterodera schachtii interacts with Arabidopsis pectin methylesterase: cooperative cell wall modification during parasitismTarek Hewezi
Department of Plant Pathology, Iowa State University, Ames, Iowa 50011, USA
Plant Cell 20:3080-93. 2008..These data indicate that CBP directly interacts with PME3 thereby activating and potentially targeting this enzyme to aid cyst nematode parasitism...
- Gene activation using FLP recombinase in C. elegansM Wayne Davis
Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah, United States of America
PLoS Genet 4:e1000028. 2008..We show that we can use this to inactivate synaptic transmission in all neurons or a subset of neurons in a FLP-dependent manner...
- Localization of the mei-1 gene product of Caenorhaditis elegans, a meiotic-specific spindle componentS Clark-Maguire
Department of Medical Biochemistry, University of Calgary, Alberta, Canada
J Cell Biol 126:199-209. 1994..The genes mei-2 and mel-26 are part of a regulatory network that confines mei-1 activity to meiosis...
- Dramatic age-related changes in nuclear and genome copy number in the nematode Caenorhabditis elegansTamara R Golden
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
Aging Cell 6:179-88. 2007..These changes are delayed or attenuated in long-lived daf-2 mutants. We propose that these changes are important pathobiological characteristics of aging nematodes...
- A phylogenomic profile of globinsSerge N Vinogradov
Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
BMC Evol Biol 6:31. 2006..The single-domain globins encompass sequences related to chimeric globins and "truncated" hemoglobins with a 2-over-2 instead of the canonical 3-over-3 alpha-helical fold...
- RNAi mediated silencing of actin expression in adult Litomosoides sigmodontis is specific, persistent and results in a phenotypeKenneth Pfarr
Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
Int J Parasitol 36:661-9. 2006..Thus, the use of lower dsRNA concentrations and proper controls for off-target effects make RNAi a viable method to study the function of filarial genes...
- DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGF beta pathway to regulate C. elegans dauer developmentLi S da Graca
Department of Biochemistry and Molecular Biology, Rutgers University, Piscataway, NJ 08854, USA
Development 131:435-46. 2004....
- The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzymeJ Yuan
Program of Neurosciences, Harvard Medical School, Boston, Massachusetts 02115
Cell 75:641-52. 1993..We propose that the CED-3 protein acts as a cysteine protease in the initiation of programmed cell death in C. elegans and that cysteine proteases also function in programmed cell death in mammals...
- The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitismChristoph Dieterich
Max Planck Institute for Developmental Biology, Spemannstrasse 37, 72076 Tubingen, Germany
Nat Genet 40:1193-8. 2008..Thus, comparative genomics analysis of three ecologically distinct nematodes offers a unique opportunity to investigate the association between genome structure and lifestyle...
- Immune evasion genes from filarial nematodesR M Maizels
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
Int J Parasitol 31:889-98. 2001....
- The fork head transcription factor FKTF-1b from Strongyloides stercoralis restores DAF-16 developmental function to mutant Caenorhabditis elegansHolman C Massey
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
Int J Parasitol 36:347-52. 2006..This indicates that, unlike FKTF-1b, the S. stercoralis transcription factor FKTF-1a cannot trigger the shift to dauer-specific gene expression in C. elegans...
- An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegansH A Tissenbaum
Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Genetics 148:703-17. 1998..The regulation of fertility, life span, and metabolism by an insulin-like signaling pathway is similar to the endocrine regulation of metabolism and fertility by mammalian insulin signaling...
- The SynMuv genes of Caenorhabditis elegans in vulval development and beyondDavid S Fay
University of Wyoming, College of Agriculture, Department of Molecular Biology, Dept 3944, 1000 E University Avenue, Laramie, WY 82071, USA
Dev Biol 306:1-9. 2007..Recent advances have led to a greater mechanistic understanding of how these genes function during vulval development and have also identified roles for these genes in diverse developmental processes...
- Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methodsDebraj GuhaThakurta
Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63114, USA
Genome Res 12:701-12. 2002..The contributions of individual sites toward induction of transcription on HS are nonadditive, which indicates interaction and cross-talk between the sites, possibly through the transcription factors (TFs) binding to these sites...
- Mining the secretome of the root-knot nematode Meloidogyne chitwoodi for candidate parasitism genesErwin Roze
Laboratory of Nematology, Wageningen University, Binnenhaven 5, 6709 PD Wageningen, The Netherlands
Mol Plant Pathol 9:1-10. 2008....
- The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localizationRie Sakamoto
Department of Molecular Biology, Graduate School of Science, Nagoya University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Nagoya 464 8602, Japan
Mol Biol Cell 16:483-96. 2005..Our data support a model whereby UNC-16 and UNC-14 function together as kinesin-1 cargos and regulators for the transport or localization of synaptic vesicle components...
- The microRNAs of Caenorhabditis elegansLee P Lim
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Genes Dev 17:991-1008. 2003..Our census of the worm miRNAs and their expression patterns helps define this class of noncoding RNAs, lays the groundwork for functional studies, and provides the tools for more comprehensive analyses of miRNA genes in other species...
- Conservation and novelty in the evolution of cell adhesion and extracellular matrix genesH Hutter
Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
Science 287:989-94. 2000..A strategy for concerted evolution of new gene families, as well as conservation of adaptive genes, may underlie the differences between heterochromatin and euchromatin...
- dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval developmentC J Ceol
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Mol Cell 7:461-73. 2001..We propose that rather than being inhibited by lin-35 Rb, dpl-1 DP and efl-1 E2F act with lin-35 Rb in transcriptional repression to antagonize RTK/Ras signaling during vulval development...
- Schistosomes--proteomics studies for potential novel vaccines and drug targetsRicardo DeMarco
Departamento de Fisica e Informatica, Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, 13560 970 Sao Carlos, SP, Brazil
Drug Discov Today 14:472-8. 2009..Successful preliminary trials of two vaccine candidates that have been detected at the parasite surface by proteomics give grounds for believing that such an approach may provide a fresh start for the field...
- New perspectives on host-parasite interplay by comparative transcriptomic and proteomic analyses of Schistosoma japonicumFeng Liu
Chinese National Human Genome Center, Shanghai, China
PLoS Pathog 2:e29. 2006....
- An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegansN C Lau
Whitehead Institute for Biomedical Research, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
Science 294:858-62. 2001..The abundance of these tiny RNAs, their expression patterns, and their evolutionary conservation imply that, as a class, miRNAs have broad regulatory functions in animals...
- Identification and characterization of genes that interact with lin-12 in Caenorhabditis elegansF E Tax
Department of Genetics, University of Washington, Seattle 98195, USA
Genetics 147:1675-95. 1997..Our analysis of these suppressors suggests that the majority of these genes are part of a shared lin-12/glp-1 signal transduction pathway, or act to regulate the expression or stability of lin-12 and glp-1...
- emo-1, a Caenorhabditis elegans Sec61p gamma homologue, is required for oocyte development and ovulationK Iwasaki
Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Cell Biol 134:699-714. 1996..We propose that the emo-1 gene product acts in the transport of secreted and transmembrane proteins in C. elegans oocytes, and is necessary for both oogenesis and the coupling of ovulation with meiotic maturation...
- Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease geneD Levitan
Department of Molecular Biology, Princeton University, New Jersey 08544, USA
Nature 377:351-4. 1995..The high degree of sequence conservation suggests that the function of the SEL-12 and S182 proteins may also be conserved...
- Temporal control of cell-specific transgene expression in Caenorhabditis elegansTaulant Bacaj
Laboratory of Developmental Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Genetics 176:2651-5. 2007..We demonstrate the utility of this method for timed reporter gene expression and for temporal studies of gene function...
- The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determinationT von Zelewsky
Institute of Zoology, Department of Biology, University of Fribourg, Perolles, CH 1700 Fribourg, Switzerland
Development 127:5277-84. 2000....
- Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryosB Etemad-Moghadam
Section of Genetics and Development, Cornell University, Ithaca, New York 14853, USA
Cell 83:743-52. 1995..In addition, the distribution of the PAR-3 protein correlates with differences in cleavage spindle orientation and suggests a mechanism by which PAR-3 contributes to control of cleavage pattern...
- The forkhead gene family of Caenorhabditis elegansIan A Hope
School of Biology, University of Leeds, Leeds LS2 9JT, UK
Gene 304:43-55. 2003..elegans. Comparisons of expression patterns and RNAi/mutant phenotypes for all 15 C. elegans forkhead genes reveal the potential complexity of functional interactions for this gene family...
- Mechanistic insights and identification of two novel factors in the C. elegans NMD pathwayDasa Longman
Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom
Genes Dev 21:1075-85. 2007..elegans that we have termed smgl (for smg lethal). We show that the encoded proteins are conserved throughout evolution and are required for NMD in C. elegans and also in human cells...
- A C. elegans orphan nuclear receptor contributes to xenobiotic resistanceT H Lindblom
Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
Curr Biol 11:864-8. 2001..We conclude that NHR-8 functions in the nematode xenobiotic defense system and that NHR-8 and PGP-3 have overlapping, but distinct, spectra of toxin specificity...
- Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegansHannes Lans
MGC Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus MC, 3000 CA Rotterdam, The Netherlands
Dev Biol 303:474-82. 2007..We expect that the implication of specific G proteins will eventually contribute to the identification of the sensory cues that determine the rate of aging in C. elegans...
- A cDNA encoding Tc-MUC-5, a mucin from Toxocara canis larvae identified by expression screeningA Doedens
Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, EH9 3JT, Edinburgh, UK
Acta Trop 79:211-7. 2001..7%), suggesting that this protein is not part of the TES-120 family of surface coat proteins...
- Binary specification of the embryonic lineage in Caenorhabditis elegansT Kaletta
Max Planck Institut fur Biochemie, Martinsried, Germany
Nature 390:294-8. 1997..Most blastomere identities in C. elegans may therefore stem from a process of stepwise binary diversification...
- A non-muscle myosin required for embryonic polarity in Caenorhabditis elegansS Guo
Section of Genetics and Development, Cornell University, Ithaca, New York 14853, USA
Nature 382:455-8. 1996..We therefore conclude the NMY-2 is required for establishing cellular polarity in C. elegans embryos...
- Molecular analysis of nematode diversity and the evolution of parasitismM Dorris
Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, UK
Parasitol Today 15:188-93. 1999....
- Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1William M Winston
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Science 295:2456-9. 2002..One of these loci, sid-1, encodes a conserved protein with predicted transmembrane domains. SID-1 is expressed in cells sensitive to RNAi, is localized to the cell periphery, and is required cell-autonomously for systemic RNAi...
- EGL-38 Pax regulates the ovo-related gene lin-48 during Caenorhabditis elegans organ developmentA D Johnson
Department of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA
Development 128:2857-65. 2001..These experiments demonstrate a functional link between Pax and Ovo transcription factors, and provide a model for how Pax transcription factors can regulate different target genes in different cells...
- Evolution of the Caenorhabditis elegans genomeAsher D Cutter
Department of Ecology and Evolutionary Biology and the Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario, Canada
Mol Biol Evol 26:1199-234. 2009..We also emphasize the potential importance of evolution in the gonochoristic (female and male) ancestors of the androdioecious (hermaphrodite and male) C. elegans as the source for many of its genomic and developmental patterns...
- A role for autophagy in the extension of lifespan by dietary restriction in C. elegansMalene Hansen
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
PLoS Genet 4:e24. 2008....
- The Kallmann syndrome gene homolog in C. elegans is involved in epidermal morphogenesis and neurite branchingElena I Rugarli
Telethon Institute of Genetics and Medicine TIGEM, via P Castellino III, 80131 Naples, Italy
Development 129:1283-94. 2002..Our findings add a new player to the set of molecules, which appear to underlie both morphogenesis and axonal/neuronal navigation in vertebrates and invertebrates...
- A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegansInsuk Lee
Center for Systems and Synthetic Biology, Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas, 2500 Speedway, MBB 3 210, Austin, Texas 78712, USA
Nat Genet 40:181-8. 2008..We conclude that an analogous network for human genes might be similarly predictive and thus facilitate identification of disease genes and rational therapeutic targets...
- Transcriptional profile of aging in C. elegansJames Lund
Department of Developmental Biology, Stanford University Medical Center, Stanford, CA 94305, USA
Curr Biol 12:1566-73. 2002..Several distinct mechanisms including an altered rate of aging, increased resistance to stress, decreased metabolic rate, or alterations in a program causing organismic aging and death have been proposed to underlie these mutants...
- Fat metabolism links germline stem cells and longevity in C. elegansMeng C Wang
Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
Science 322:957-60. 2008..This lipase is a key factor in the lipid hydrolysis and increased longevity that are induced by decreased insulin signaling. These results suggest a link between C. elegans fat metabolism and longevity...
- Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planariaPeter W Reddien
Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, 84132, USA
Dev Cell 8:635-49. 2005....
- Hormesis and aging in Caenorhabditis elegansJames R Cypser
University of Colorado, Institute for Behavioral Genetics, Box 447 Boulder, CO 80309, Fedex, 1480 30th St, Boulder, CO 80303, USA
Exp Gerontol 41:935-9. 2006..Mutations in three other genes of this pathway (daf-3, daf-5, and age-1) do not block induced life extension or induced thermotolerance; daf-5 mutants may be unusually sensitive to hormetic conditions...
- A compendium of Caenorhabditis elegans regulatory transcription factors: a resource for mapping transcription regulatory networksJohn S Reece-Hoyes
Institute of Integrative and Comparative Biology, Faculty of Biological Sciences, School of Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK
Genome Biol 6:R110. 2005....
- A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegansSarah L Crittenden
Howard Hughes Medical Institute, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
Nature 417:660-3. 2002..We suggest that regulation by PUF proteins may be an ancient and widespread mechanism for control of stem cells...
- The role of lineage-specific gene family expansion in the evolution of eukaryotesOlivier Lespinet
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
Genome Res 12:1048-59. 2002..LSEs seem to be one of the principal means of adaptation and one of the most important sources of organizational and regulatory diversity in crown-group eukaryotes...
- Control of C. elegans larval development by neuronal expression of a TGF-beta homologP Ren
Molecular Biology Program and Division of Biological Sciences, 311 Tucker Hall, University of Missouri, Columbia, MO 65211, USA
Science 274:1389-91. 1996..When the food/pheromone ratio is high, the level of daf-7 mRNA peaks during the L1 larval stage, when commitment to non-dauer development is made...
- Prolyl 4-hydroxylase is an essential procollagen-modifying enzyme required for exoskeleton formation and the maintenance of body shape in the nematode Caenorhabditis elegansA D Winter
Wellcome Centre for Molecular Parasitology, Anderson College, The University of Glasgow, Glasgow G11 6NU, United Kingdom
Mol Cell Biol 20:4084-93. 2000..This study demonstrates in vivo that this enzyme complex plays a central role in extracellular matrix formation and is essential for normal metazoan development...
- RNAi from plants to nematodesGodelieve Gheysen
Department of Molecular Biotechnology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
Trends Biotechnol 25:89-92. 2007..Recent work has demonstrated that the expression in a host plant of double-stranded RNA targeting housekeeping or parasitism genes in the root-knot nematode resulted in resistance to nematode infection...
- Functional genomics of hsp-90 in parasitic and free-living nematodesVictoria Gillan
Parasitology Group, Division of Infection and Immunity, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK
Int J Parasitol 39:1071-81. 2009..These results indicate that factors other than the level of sequence identity are important for determining whether parasite genes can functionally complement in C. elegans...
- Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous systemM Maduro
Department of Biological Sciences, University of Alberta, Edmonton, Canada
Genetics 141:977-88. 1995..Expression of an unc-119/lacZ fusion in transgenic animals is seen in many neurons, suggesting that the unc-119 mutant phenotype is due to a defect in the nervous system...
- Ectopic expression of a Haemonchus contortus GATA transcription factor in Caenorhabditis elegans reveals conserved function in spite of extensive sequence divergenceAnnabelle Couthier
Department of Veterinary Parasitology, Faculty of Veterinary Medicine, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK
Mol Biochem Parasitol 133:241-53. 2004..This approach of ectopic expression using an inducible promoter provides an effective way in which to use C. elegans for the in vivo functional analysis of parasitic nematode genes...
- Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent diseaseT E Johnson
Institute for Behavioral Genetics, University of Colorado at Boulder, 80309, USA
J Inherit Metab Dis 25:197-206. 2002..In mammals, both dietary restriction and hormesis are phenomena in which the endogenous level of resistance to stress has been upregulated; both of these interventions extend longevity, suggesting possible evolutionary conservation...
- NEURAL CONTROL OF A MOTOR PROGRAMJames Thomas; Fiscal Year: 2002..We will also continue genetic screens to identify additional potential targets. ..
- GENETIC ANALYSIS OF CHEMOSENSATION IN C ELEGANSJames Thomas; Fiscal Year: 2003..All of the pathways under study here correspond to important regulatory pathways in humans, and many of the genes are affected in various inherited disorders. ..
- Proteogenomic Analysis of C. elegansJames Thomas; Fiscal Year: 2007..elegans proteome and a high-throughput pipeline that will allow similar analysis of any complex animal or plant proteome whose genome sequence is available. [unreadable] [unreadable] [unreadable]..
- MARINER TRANSPOSONS OF MAMMALSHugh Robertson; Fiscal Year: 2001..It will also reveal how occasionally particular copies of transposons can become integral parts of their host genetic complements. ..
- Gustatory and olfactory receptors of Anopheles gambiaeHugh Robertson; Fiscal Year: 2006..This work will also contribute to our overall understanding of the molecular basis of chemoreception in insects and other animals. [unreadable] [unreadable]..
- Functional Genomics:Complex Biological SystemsStuart Kim; Fiscal Year: 2003..The goal of the meeting is to integrate advances in human disease, modeling of genetic networks, quantitative trait mapping, and data mining techniques. ..
- 2001 International C. elegans MeetingPaul Sternberg; Fiscal Year: 2001..Previous C. elegans meetings have led to the exchange of knowledge, ideas, methods, mutants, and clones, and have been vital in fostering the sense of excitement, collegiality and cooperativity that characterize this field. ..
- Tissue Fragility genes in C. elegansJohn Plenefisch; Fiscal Year: 2005..abstract_text> ..
- REGULATION OF GENE EXPRESSION DURING ORGANOGENESISHelen Chamberlin; Fiscal Year: 2004..elegans. A third aim is to functionally characterize this second gene to determine whether its product shares in vivo functions with EGL-38, or whether it regulates lin-48 and cdh-3 expression in other organs. ..
- MAP kinase signal specificity in the C. elegans germlineValerie Reinke; Fiscal Year: 2007..Together these experiments should build toward a comprehensive understanding of the mechanisms used to produce a specific cell fate in response to a generally used signaling pathway. ..
- Development of a novel nematode/Wolbachia targetClotilde Carlow; Fiscal Year: 2007..This will provide the basis for discovering a new class of drugs that may be used in veterinary and human medicine. [unreadable] [unreadable]..
- A GENOMIC APPROACH TO PARASITES FROM THE PHYLUM NEMATODAMakedonka Mitreva; Fiscal Year: 2007..Working with collaborators, a limited number of novel domains will be characterized in more detail with an emphasis on postulating molecular or cellular function. ..
- PROTEOMIC ANALYSIS OF DECREASED AUTOPHAGY IN AGINGAna Cuervo; Fiscal Year: 2005..abstract_text> ..
- Cell Type Specific Regulators of Cell DeathJohn Cameron; Fiscal Year: 2006..In this way I will use the extraordinarily powerful methods available in C. elegans for analysis of how mutations affect cell fates to test models of how mutant mammalian genes are oncogenic. ..
- CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENTSara Lustigman; Fiscal Year: 2005..This will provide the basis for developing effective drugs, targeting cysteine proteases, to control onchocerciasis and filariasis in the future. ..
- DYNAMICS AND FUNCTION OF G4 DNANancy Maizels; Fiscal Year: 2007..abstract_text> ..
- STAGE and FAIRE for Regulatory Element IdentificationVishwanath Iyer; Fiscal Year: 2006..abstract_text> ..
- Gamete Interactions in Caenorhabditis elegansAndrew Singson; Fiscal Year: 2007..This work will complement fertility studies in other organisms as well as provide insights into the mechanisms of cell-cell interactions and the diversity of reproductive strategies. [unreadable] [unreadable] [unreadable]..
- Variation of D. melanogaster chromosome 4Manyuan Long; Fiscal Year: 2006..These studies should add significantly to the understanding of the evolutionary genetics of the Drosophila fourth chromosome. ..
- Cytokinesis and the Cytoskeleton in C. elegans EmbryosBRUCE A BOWERMAN; Fiscal Year: 2010..Matthias Peter at the ETH in Zurich, Switzerland. The processes and genes we propose to investigate are relevant to important human diseases, including cancer and neurodegenerative disease. ..
- Lifespan determination and stress response in C. elegansGordon Lithgow; Fiscal Year: 2006..Thirdly, we will identify and manipulate the levels of endocrine signals that act downstream of the insulin/IGF signaling pathway to limit lifespan. ..
- Detection of Distribution of New Genes in Drosophila PhylogenyMANYUAN NO LONG; Fiscal Year: 2010..The results from these four categories of studies will generate the first phylogenetic distribution of new genes and provide the fresh-insight into the rates and patterns of new gene originations in genomes. ..
- A Helminth-Derived Immune Potentiator for BiodefenseSara Lustigman; Fiscal Year: 2006..abstract_text> ..
- Regulation and Function of Hox gene lin-39 in C elegansDAVID EISENMANN; Fiscal Year: 2007..elegans, for which full genomic sequence is available and functional genomic approaches are available. ..
- EVOLUTION OF IMMUNE RECOGNITION AND EVASIONAustin L Hughes; Fiscal Year: 2010..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
- MOLECULAR MECHANISMS OF ISOTYPE SWITCH RECOMBINATIONNancy Maizels; Fiscal Year: 2009..abstract_text> ..
- Temperature Sensation and Its Behavioral ConsequencesMIRIAM GOODMAN; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Trans-splicing in C. elegansThomas Blumenthal; Fiscal Year: 2007..We will determine what functions these proteins have in 3' end formation. These studies should provide important new insight into how 3' end cleavage can occur without accompanying transcription termination. ..
- Vaccine induced resistance against E. granulosus in dogsWenbao Zhang; Fiscal Year: 2007..granulosus infection by vaccination with the recombinant proteins. We will test humoral and cellular responses generated during vaccination to determine possible correlations of the immune parameters with protection. ..
- Gene networks specifying cell lineages in a polychaeteBruce Bowerman; Fiscal Year: 2007..Newly discovered and conserved loci will also be studied in C. elegans and Drosophila. [unreadable] [unreadable]..
- Comparative Biology of p53, Checkpoint and LongevityGordon Lithgow; Fiscal Year: 2007..As these factors appear to affect aging in both simple invertebrates and mammals, we expect to define broad mechanisms by which cellular and organismal aging are co-regulated. ..
- PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAESara Lustigman; Fiscal Year: 2001..These studies should, therefore, be instrumental in developing a vaccine against onchocerciasis with anticipated clinical application. ..
- Control of cell polarity in the C. elegans zygoteGeraldine Seydoux; Fiscal Year: 2005..We anticipate that our studies will provide significant insights into these processes by taking advantage of the experimental attributes of a simple model system...
- C. elegans, Aging and High Throughput Screening (RMI)Gordon Lithgow; Fiscal Year: 2004..elegans for HTS. Our longer term goal is to undertake HTS for compounds that protect against oxidative stress, extend lifespan and translate into mammalian models of age-related diseases such as Alzheimer's and Parkinson's. ..
- Isolation of src-like signaling componentsLISA MADUZIA; Fiscal Year: 2005..abstract_text> ..
- Gordon Research Conference, Biology of Aging, 2004Gordon Lithgow; Fiscal Year: 2004..abstract_text> ..
- MITOCHONDRIAL OXIDATIVE STRESS AND NEURODEGENERATIONSimon Melov; Fiscal Year: 2004....
- Fluorescent Activated Cell Sorter for C. elegans (worms)Susan Mango; Fiscal Year: 2004..elegans researchers at the University of Utah. It would both facilitate existing research projects and permit the development of new projects that could not function without this novel instrument. ..
- 2003/2005 INTERNATIONAL C. ELEGANS MEETINGSGeraldine Seydoux; Fiscal Year: 2004..Previous C. elegans meetings have led to the exchange of knowledge, ideas, methods, mutants, and clones and have been vital in fostering the sense of excitement and the collegiality and cooperativity that characterize this field. ..
- SEQUENCING THE MOUSE GENOMERichard Wilson; Fiscal Year: 2004..This sequence information will be an invaluable tool for gene discovery and annotation of the mouse and human genomes. ..
- Function of a Neuropeptide Gene Family in C. elegansChristine Li; Fiscal Year: 2006..In addition, because C. elegans is the current genetic model system for parasitic nematodes, elucidating the functions of neuropeptides and their signaling pathways may identify new antihelmintic drug targets. ..
- Comparative Functional Genomics of Longevity AssuranceSimon Melov; Fiscal Year: 2006..In years four and five we will apply the functional genomic approach defined above, as well as statistical methods refined during the first three years, to the analysis of mouse RI lines with differential lifespans. ..
- Gordon Conference-Autophagy/Stress/Development/DiseaseAna Cuervo; Fiscal Year: 2007....
- Regulation of Programmed Cell Death in C.elegansJohn Cameron; Fiscal Year: 2008..elegans ventral nerve cord. We will use RNAi to screen 25 candidate genes and identify those that act with lin-59 to promote survival of the VC motor neurons. ..
- REGULATION OF SPLICE SITE CHOICE IN C. ELEGANSALAN ZAHLER; Fiscal Year: 2009..3- To characterize suppressors of 5'and 3'splice site defects in order to illuminate the mechanisms of splice site selection. ..
- Genetic Regulation of Mating Behavior in C. elegan MalesLuis Garcia; Fiscal Year: 2009..Additionally, this project will identify components of activating pathways that must be attenuated by unc-103 during periods between mating. ..
- daf-12 Target Genes during C. elegans agingAlfred Fisher; Fiscal Year: 2005..abstract_text> ..
- Control of nematode developmentEric Lambie; Fiscal Year: 2005..Therefore, the results of this work are likely to be highly significant with regard to the etiology of human disease. ..
- INDYs: A Link between Membrane Transport and Life SpanVadivel Ganapathy; Fiscal Year: 2006..abstract_text> ..
- PROBABILISTIC MODELS OF PROTEIN AND RNA STRUCTURESean Eddy; Fiscal Year: 2006..A final aim proposes a method for identifying the mRNA targets of regulatory RNAs (such as the newly discovered micro RNAs) by comparative genome analysis. ..
- RNAi Mediated Gene Disruption in Caenorhabditis ElegansWayne Van Voorhies; Fiscal Year: 2006..Such worms could identify candidate genes affecting processes that act "downstream" from the metabolic rate and provide valuable insights into the causes of aging and mechanisms by which it can be attenuated. ..
- Gamete Interactions in Caenorhabditis elegansAndrew Singson; Fiscal Year: 2005..This work will provide new insight into cell-cell interactions, conception and complement studies of fertilization in other organisms. ..
- Genetic Dissection of Sickle Cell Anemia PhenotypesPaola Sebastiani; Fiscal Year: 2006..abstract_text> ..
- Regulation of Innate Immunity by Virulence FactorsAlejandro Aballay; Fiscal Year: 2006..elegans. 3) Elucidate the mechanism by which the genes identified in Aims 1 and 2 contribute to C. elegans innate immunity pathways conserved in mammals. ..
- Gene Duplication and Genome EvolutionAustin Hughes; Fiscal Year: 2004..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
- Conference on Genome Instability and RepairNancy Maizels; Fiscal Year: 2005..The molecular and mechanistic emphasis on pathways critical for genomic stability in a variety of biological contexts is designed to attract a unique audience of researchers at this interface. ..
- Genetic Control of Development in C elegansStuart Kim; Fiscal Year: 2006..abstract_text> ..
- TELOMERES OF BDELLOID AND MONOGONONT ROTIFERSMatthew Meselson; Fiscal Year: 2007..As telomeres are involved in diverse pathologies, including metastatic growth, the results of the proposed study may provide insight into mechanisms and possible therapies of importance. ..