helminth genes

Summary

Summary: The functional hereditary units of HELMINTHS.

Top Publications

  1. ncbi Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    A Fire
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Nature 391:806-11. 1998
  2. ncbi Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
    Ravi S Kamath
    Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Nature 421:231-7. 2003
  3. ncbi Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
    Nature 424:277-83. 2003
  4. ncbi daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    K D Kimura
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 277:942-6. 1997
  5. pmc Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans
    R S Kamath
    Wellcome CRC Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK
    Genome Biol 2:RESEARCH0002. 2001
  6. pmc The genome of the blood fluke Schistosoma mansoni
    Matthew Berriman
    Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK
    Nature 460:352-8. 2009
  7. ncbi Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    A Grishok
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 106:23-34. 2001
  8. ncbi Autophagy genes are essential for dauer development and life-span extension in C. elegans
    Alicia Melendez
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Science 301:1387-91. 2003
  9. ncbi A gene-coexpression network for global discovery of conserved genetic modules
    Joshua M Stuart
    Stanford Medical Informatics, 251 Campus Drive, Medical School Office Building X 215, Stanford, CA 94305 5329, USA
    Science 302:249-55. 2003
  10. ncbi Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    B Wightman
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Cell 75:855-62. 1993

Research Grants

  1. NEURAL CONTROL OF A MOTOR PROGRAM
    James Thomas; Fiscal Year: 2002
  2. GENETIC ANALYSIS OF CHEMOSENSATION IN C ELEGANS
    James Thomas; Fiscal Year: 2003
  3. Proteogenomic Analysis of C. elegans
    James Thomas; Fiscal Year: 2007
  4. MARINER TRANSPOSONS OF MAMMALS
    Hugh Robertson; Fiscal Year: 2001
  5. Gustatory and olfactory receptors of Anopheles gambiae
    Hugh Robertson; Fiscal Year: 2006
  6. Functional Genomics:Complex Biological Systems
    Stuart Kim; Fiscal Year: 2003
  7. 2001 International C. elegans Meeting
    Paul Sternberg; Fiscal Year: 2001
  8. Tissue Fragility genes in C. elegans
    John Plenefisch; Fiscal Year: 2005
  9. REGULATION OF GENE EXPRESSION DURING ORGANOGENESIS
    Helen Chamberlin; Fiscal Year: 2004
  10. MAP kinase signal specificity in the C. elegans germline
    Valerie Reinke; Fiscal Year: 2007

Detail Information

Publications258 found, 100 shown here

  1. ncbi Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    A Fire
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Nature 391:806-11. 1998
    ....
  2. ncbi Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
    Ravi S Kamath
    Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Nature 421:231-7. 2003
    ..Our resulting data set and reusable RNAi library of 16,757 bacterial clones will facilitate systematic analyses of the connections among gene sequence, chromosomal location and gene function in C. elegans...
  3. ncbi Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
    Coleen T Murphy
    Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
    Nature 424:277-83. 2003
    ....
  4. ncbi daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
    K D Kimura
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 277:942-6. 1997
    ..Life-span regulation by insulin-like metabolic control is analogous to mammalian longevity enhancement induced by caloric restriction, suggesting a general link between metabolism, diapause, and longevity...
  5. pmc Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans
    R S Kamath
    Wellcome CRC Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK
    Genome Biol 2:RESEARCH0002. 2001
    ....
  6. pmc The genome of the blood fluke Schistosoma mansoni
    Matthew Berriman
    Wellcome Trust Sanger Institute, Cambridge CB10 1SD, UK
    Nature 460:352-8. 2009
    ..The information generated provides an invaluable resource for the research community to develop much needed new control tools for the treatment and eradication of this important and neglected disease...
  7. ncbi Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    A Grishok
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 106:23-34. 2001
    ..Our findings suggest that a common processing machinery generates guide RNAs that mediate both RNAi and endogenous gene regulation...
  8. ncbi Autophagy genes are essential for dauer development and life-span extension in C. elegans
    Alicia Melendez
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Science 301:1387-91. 2003
    ..elegans orthologs of the yeast autophagy genes APG1, APG7, APG8, and AUT10. Thus, autophagy is a cellular pathway essential for dauer development and life-span extension in C. elegans...
  9. ncbi A gene-coexpression network for global discovery of conserved genetic modules
    Joshua M Stuart
    Stanford Medical Informatics, 251 Campus Drive, Medical School Office Building X 215, Stanford, CA 94305 5329, USA
    Science 302:249-55. 2003
    ..By assembling these links into a gene-coexpression network, we found several components that were animal-specific as well as interrelationships between newly evolved and ancient modules...
  10. ncbi Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    B Wightman
    Department of Molecular Biology, Massachusetts General Hospital, Boston 02114
    Cell 75:855-62. 1993
    ..These data suggest a molecular mechanism for Lin-14p temporal gradient formation: the lin-4 RNAs base pair to sites in the lin-14 3'UTR to form multiple RNA duplexes that down-regulate lin-14 translation...
  11. pmc A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in Caenorhabditis elegans
    S W Knight
    Department of Biochemistry and Howard Hughes Medical Institute, University of Utah, 50 North Medical Drive, Room 211, Salt Lake City, UT 84132, USA
    Science 293:2269-71. 2001
    ..Mutant animals have germ line defects that lead to sterility, suggesting that cleavage of dsRNA to short pieces is a requisite event in normal development...
  12. ncbi A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity
    Dennis H Kim
    Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Science 297:623-6. 2002
    ..These data suggest that this MAP kinase signaling cassette represents an ancient feature of innate immune responses in evolutionarily diverse species...
  13. ncbi Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation
    Seung Wook Oh
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Genet 38:251-7. 2006
    ..We also demonstrate that DAF-16 is recruited to multiple promoters to coordinate regulation of its downstream targets. The large number of target genes discovered provides insight into how DAF-16 controls diverse biological functions...
  14. pmc The genetics of feeding in Caenorhabditis elegans
    L Avery
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9038
    Genetics 133:897-917. 1993
    ..eat-6 and eat-12 mutants failed to relax their pharyngeal muscles properly. These pharyngeal motion defects are most easily explained as resulting from abnormal electrical excitability of the pharyngeal muscle membrane...
  15. ncbi The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor
    F J Slack
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Mol Cell 5:659-69. 2000
    ..We suggest that late larval activation of let-7 RNA expression downregulates LIN-41 to relieve inhibition of lin-29...
  16. ncbi Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans
    B Sönnichsen
    Cenix BioScience GmbH, Tatzberg 47 51, D 01307 Dresden, Germany
    Nature 434:462-9. 2005
    ....
  17. pmc SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A
    Kirk R Anders
    Department of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    EMBO J 22:641-50. 2003
    ..Our results suggest that PP2A is the SMG-2 phosphatase, and the role of SMG-5 is to direct PP2A to its SMG-2 substrate. We discuss cycles of SMG-2 phosphorylation and their roles in NMD...
  18. ncbi Regulation of life-span by germ-line stem cells in Caenorhabditis elegans
    Nuno Arantes-Oliveira
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143 0448, USA
    Science 295:502-5. 2002
    ..We propose that the germ-line stem cells affect life-span by influencing the production of, or the response to, a steroid hormone that promotes longevity...
  19. ncbi Collagens, modifying enzymes and their mutations in humans, flies and worms
    Johanna Myllyharju
    Collagen Research Unit, Biocenter Oulu and Department of Medical Biochemistry and Molecular Biology, University of Oulu, FIN 90014 Oulu, Finland
    Trends Genet 20:33-43. 2004
    ..elegans mutants are also available to analyse the collagen gene family and their modifying enzymes...
  20. pmc p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans
    Emily R Troemel
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 2:e183. 2006
    ..The contribution of the PMK-1 pathway to the enhanced lifespan of daf-2 mutants suggests that innate immunity is an important determinant of longevity...
  21. ncbi The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9
    B Conradt
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 93:519-29. 1998
    ..We propose that EGL-1 activates programmed cell death by binding to and directly inhibiting the activity of CED-9, perhaps by releasing the cell death activator CED-4 from a CED-9/CED-4-containing protein complex...
  22. ncbi Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
    Duo Wang
    Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 436:593-7. 2005
    ..These findings suggest that mutations in Rb pathway components cause cells to revert to patterns of gene expression normally restricted to germ cells. Rb may act by a similar mechanism to transform mammalian cells...
  23. pmc The genetics of caloric restriction in Caenorhabditis elegans
    B Lakowski
    Department of Biology, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec, Canada H3A 1B1
    Proc Natl Acad Sci U S A 95:13091-6. 1998
    ..In contrast, we find that food restriction does not further increase the life span of long-lived clk-1 mutants, suggesting that clk-1 and caloric restriction affect similar processes...
  24. ncbi Genes required for GABA function in Caenorhabditis elegans
    S L McIntire
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Nature 364:334-7. 1993
    ..Some of these genes are likely to encode previously unidentified proteins required for GABA function...
  25. ncbi Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance
    W B Derry
    Department of Molecular, Cellular, and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Science 294:591-5. 2001
    ..These findings show that C. elegans p53 mediates multiple stress responses in the soma, and mediates apoptosis and meiotic chromosome segregation in the germ line...
  26. pmc Lifespan regulation by evolutionarily conserved genes essential for viability
    Sean P Curran
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 3:e56. 2007
    ..These results suggest that insulin-signaling pathways play a role in regulation of aging at any stage in life...
  27. pmc Roles for 147 embryonic lethal genes on C.elegans chromosome I identified by RNA interference and video microscopy
    P Zipperlen
    University of Cambridge, Wellcome CRC Institute and Department of Genetics, Tennis Court Road, Cambridge CB2 1QR, UK
    EMBO J 20:3984-92. 2001
    ....
  28. ncbi Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
    Laura A Herndon
    Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, A232 Nelson Biological Laboratories, 604 Allison Road, Piscataway, New Jersey 08854, USA
    Nature 419:808-14. 2002
    ..Strikingly, we found strong evidence that stochastic as well as genetic factors are significant in C. elegans ageing, with extensive variability both among same-age animals and between cells of the same type within individuals...
  29. pmc Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR
    Katie L Styer
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 322:460-4. 2008
    ..elegans, suggesting that GPCRs may participate in neural circuits that receive inputs from either pathogens or infected sites and integrate them to coordinate appropriate immune responses...
  30. pmc Quantitative evidence for conserved longevity pathways between divergent eukaryotic species
    Erica D Smith
    Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA
    Genome Res 18:564-70. 2008
    ..Together, these findings indicate that the genetic component of life span determination is significantly conserved between divergent eukaryotic species, and suggest pathways that are likely to play a similar role in mammalian aging...
  31. ncbi Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
    Kaveh Ashrafi
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nature 421:268-72. 2003
    ....
  32. ncbi The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    B J Reinhart
    Department of Molecular Biology, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA
    Nature 403:901-6. 2000
    ..We propose that the sequential stage-specific expression of the lin-4 and let-7 regulatory RNAs triggers transitions in the complement of heterochronic regulatory proteins to coordinate developmental timing...
  33. ncbi Pod-2, along with pod-1, defines a new class of genes required for polarity in the early Caenorhabditis elegans embryo
    A Tagawa
    Division of Biology, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA
    Dev Biol 233:412-24. 2001
    ..Our data suggest that pod-2 may be required to properly position an a-p polarity cue...
  34. pmc A polymorphism in npr-1 is a behavioral determinant of pathogen susceptibility in C. elegans
    Kirthi C Reddy
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 323:382-4. 2009
    ..For C. elegans, bacteria represent food but also a potential source of infection. Our data underscore the importance of behavioral responses to oxygen levels in finding an optimal balance between these potentially conflicting cues...
  35. ncbi The versatile worm: genetic and genomic resources for Caenorhabditis elegans research
    Igor Antoshechkin
    Division of Biology 156 29, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA
    Nat Rev Genet 8:518-32. 2007
    ..We also hope that it will be helpful in identifying new research opportunities and will promote the development of additional resources...
  36. ncbi A correlation between host-mediated expression of parasite genes as tandem inverted repeats and abrogation of development of female Heterodera glycines cyst formation during infection of Glycine max
    Vincent P Klink
    Department of Biological Sciences, Mississippi State University, Harned Hall, Rm 310, Mississippi State, MS 39762, USA
    Planta 230:53-71. 2009
    ..The effect resembles RNA interference. The methodology has been used here as an alternative approach to engineer resistance to H. glycines...
  37. ncbi Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos
    C E Rocheleau
    Department of Cell Biology, Program in Molecular Medicine, University of Massachusetts Cancer Center, Worcester 01605, USA
    Cell 90:707-16. 1997
    ..We present evidence that there may be partially redundant inputs into endoderm specification and that a subset of these genes appear also to function in determining cytoskeletal polarity in certain early blastomeres...
  38. pmc Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions
    Femke Simmer
    Hubrecht Laboratory, Centre for Biomedical Genetics, Utrecht, The Netherlands
    PLoS Biol 1:E12. 2003
    ..elegans genome. The resulting dataset will be valuable in conjunction with other functional genomics approaches, as well as in other model organisms...
  39. ncbi MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos
    B W Draper
    Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Cell 87:205-16. 1996
    ..We propose that MEX-3 contributes to anterior-posterior asymmetry by regulating one or more mRNAs involved in specifying the fate of the posterior blastomere...
  40. ncbi Enzymes involved in the biogenesis of the nematode cuticle
    Antony P Page
    Wellcome Centre for Molecular Parasitology, The Anderson College, The University of Glasgow, Glasgow G11 6NU, UK
    Adv Parasitol 53:85-148. 2003
    ..This model system will be the main focus of this review...
  41. pmc eat-2 and eat-18 are required for nicotinic neurotransmission in the Caenorhabditis elegans pharynx
    James P McKay
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9148, USA
    Genetics 166:161-9. 2004
    ..In eat-18 mutants, the gross localization of EAT-2 at the MC synapse is normal, suggesting that it is not required for trafficking. These data indicate that eat-18 could be a novel component of the pharyngeal nicotinic receptor...
  42. ncbi The C. elegans gene vab-8 guides posteriorly directed axon outgrowth and cell migration
    B Wightman
    Department of Molecular and Cell Biology, University of California, Berkeley, 94720 3204, USA
    Development 122:671-82. 1996
    ..vab-8 encodes two genetic activities that function in the guidance of different migrations. Our results suggest that most posteriorly directed cell and growth cone migrations are guided by a common mechanism involving the vab-8 gene...
  43. pmc A genetic screen for neurite outgrowth mutants in Caenorhabditis elegans reveals a new function for the F-box ubiquitin ligase component LIN-23
    Nehal Mehta
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Genetics 166:1253-67. 2004
    ..We have thus defined separable activities of LIN-23 in two distinct processes, cell cycle control and axon patterning. We propose that LIN-23 targets distinct substrates for ubiquitination within each process...
  44. pmc Longevity determined by developmental arrest genes in Caenorhabditis elegans
    Di Chen
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 6:525-33. 2007
    ..We have isolated novel lifespan-extension genes, which may help understand the intrinsic link between organism development and adult lifespan...
  45. pmc Cellulose binding protein from the parasitic nematode Heterodera schachtii interacts with Arabidopsis pectin methylesterase: cooperative cell wall modification during parasitism
    Tarek Hewezi
    Department of Plant Pathology, Iowa State University, Ames, Iowa 50011, USA
    Plant Cell 20:3080-93. 2008
    ..These data indicate that CBP directly interacts with PME3 thereby activating and potentially targeting this enzyme to aid cyst nematode parasitism...
  46. pmc Gene activation using FLP recombinase in C. elegans
    M Wayne Davis
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah, United States of America
    PLoS Genet 4:e1000028. 2008
    ..We show that we can use this to inactivate synaptic transmission in all neurons or a subset of neurons in a FLP-dependent manner...
  47. pmc Localization of the mei-1 gene product of Caenorhaditis elegans, a meiotic-specific spindle component
    S Clark-Maguire
    Department of Medical Biochemistry, University of Calgary, Alberta, Canada
    J Cell Biol 126:199-209. 1994
    ..The genes mei-2 and mel-26 are part of a regulatory network that confines mei-1 activity to meiosis...
  48. pmc Dramatic age-related changes in nuclear and genome copy number in the nematode Caenorhabditis elegans
    Tamara R Golden
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA
    Aging Cell 6:179-88. 2007
    ..These changes are delayed or attenuated in long-lived daf-2 mutants. We propose that these changes are important pathobiological characteristics of aging nematodes...
  49. pmc A phylogenomic profile of globins
    Serge N Vinogradov
    Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    BMC Evol Biol 6:31. 2006
    ..The single-domain globins encompass sequences related to chimeric globins and "truncated" hemoglobins with a 2-over-2 instead of the canonical 3-over-3 alpha-helical fold...
  50. ncbi RNAi mediated silencing of actin expression in adult Litomosoides sigmodontis is specific, persistent and results in a phenotype
    Kenneth Pfarr
    Institute for Medical Microbiology, Immunology and Parasitology, University Clinic Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Int J Parasitol 36:661-9. 2006
    ..Thus, the use of lower dsRNA concentrations and proper controls for off-target effects make RNAi a viable method to study the function of filarial genes...
  51. ncbi DAF-5 is a Ski oncoprotein homolog that functions in a neuronal TGF beta pathway to regulate C. elegans dauer development
    Li S da Graca
    Department of Biochemistry and Molecular Biology, Rutgers University, Piscataway, NJ 08854, USA
    Development 131:435-46. 2004
    ....
  52. ncbi The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
    J Yuan
    Program of Neurosciences, Harvard Medical School, Boston, Massachusetts 02115
    Cell 75:641-52. 1993
    ..We propose that the CED-3 protein acts as a cysteine protease in the initiation of programmed cell death in C. elegans and that cysteine proteases also function in programmed cell death in mammals...
  53. pmc The Pristionchus pacificus genome provides a unique perspective on nematode lifestyle and parasitism
    Christoph Dieterich
    Max Planck Institute for Developmental Biology, Spemannstrasse 37, 72076 Tubingen, Germany
    Nat Genet 40:1193-8. 2008
    ..Thus, comparative genomics analysis of three ecologically distinct nematodes offers a unique opportunity to investigate the association between genome structure and lifestyle...
  54. ncbi Immune evasion genes from filarial nematodes
    R M Maizels
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Int J Parasitol 31:889-98. 2001
    ....
  55. pmc The fork head transcription factor FKTF-1b from Strongyloides stercoralis restores DAF-16 developmental function to mutant Caenorhabditis elegans
    Holman C Massey
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104, USA
    Int J Parasitol 36:347-52. 2006
    ..This indicates that, unlike FKTF-1b, the S. stercoralis transcription factor FKTF-1a cannot trigger the shift to dauer-specific gene expression in C. elegans...
  56. pmc An insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans
    H A Tissenbaum
    Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Genetics 148:703-17. 1998
    ..The regulation of fertility, life span, and metabolism by an insulin-like signaling pathway is similar to the endocrine regulation of metabolism and fertility by mammalian insulin signaling...
  57. pmc The SynMuv genes of Caenorhabditis elegans in vulval development and beyond
    David S Fay
    University of Wyoming, College of Agriculture, Department of Molecular Biology, Dept 3944, 1000 E University Avenue, Laramie, WY 82071, USA
    Dev Biol 306:1-9. 2007
    ..Recent advances have led to a greater mechanistic understanding of how these genes function during vulval development and have also identified roles for these genes in diverse developmental processes...
  58. pmc Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods
    Debraj GuhaThakurta
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63114, USA
    Genome Res 12:701-12. 2002
    ..The contributions of individual sites toward induction of transcription on HS are nonadditive, which indicates interaction and cross-talk between the sites, possibly through the transcription factors (TFs) binding to these sites...
  59. ncbi Mining the secretome of the root-knot nematode Meloidogyne chitwoodi for candidate parasitism genes
    Erwin Roze
    Laboratory of Nematology, Wageningen University, Binnenhaven 5, 6709 PD Wageningen, The Netherlands
    Mol Plant Pathol 9:1-10. 2008
    ....
  60. pmc The Caenorhabditis elegans UNC-14 RUN domain protein binds to the kinesin-1 and UNC-16 complex and regulates synaptic vesicle localization
    Rie Sakamoto
    Department of Molecular Biology, Graduate School of Science, Nagoya University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Nagoya 464 8602, Japan
    Mol Biol Cell 16:483-96. 2005
    ..Our data support a model whereby UNC-16 and UNC-14 function together as kinesin-1 cargos and regulators for the transport or localization of synaptic vesicle components...
  61. pmc The microRNAs of Caenorhabditis elegans
    Lee P Lim
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Genes Dev 17:991-1008. 2003
    ..Our census of the worm miRNAs and their expression patterns helps define this class of noncoding RNAs, lays the groundwork for functional studies, and provides the tools for more comprehensive analyses of miRNA genes in other species...
  62. ncbi Conservation and novelty in the evolution of cell adhesion and extracellular matrix genes
    H Hutter
    Max Planck Institute for Medical Research, Jahnstrasse 29, 69120 Heidelberg, Germany
    Science 287:989-94. 2000
    ..A strategy for concerted evolution of new gene families, as well as conservation of adaptive genes, may underlie the differences between heterochromatin and euchromatin...
  63. ncbi dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development
    C J Ceol
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Mol Cell 7:461-73. 2001
    ..We propose that rather than being inhibited by lin-35 Rb, dpl-1 DP and efl-1 E2F act with lin-35 Rb in transcriptional repression to antagonize RTK/Ras signaling during vulval development...
  64. ncbi Schistosomes--proteomics studies for potential novel vaccines and drug targets
    Ricardo DeMarco
    Departamento de Fisica e Informatica, Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, 13560 970 Sao Carlos, SP, Brazil
    Drug Discov Today 14:472-8. 2009
    ..Successful preliminary trials of two vaccine candidates that have been detected at the parasite surface by proteomics give grounds for believing that such an approach may provide a fresh start for the field...
  65. pmc New perspectives on host-parasite interplay by comparative transcriptomic and proteomic analyses of Schistosoma japonicum
    Feng Liu
    Chinese National Human Genome Center, Shanghai, China
    PLoS Pathog 2:e29. 2006
    ....
  66. ncbi An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    N C Lau
    Whitehead Institute for Biomedical Research, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 294:858-62. 2001
    ..The abundance of these tiny RNAs, their expression patterns, and their evolutionary conservation imply that, as a class, miRNAs have broad regulatory functions in animals...
  67. pmc Identification and characterization of genes that interact with lin-12 in Caenorhabditis elegans
    F E Tax
    Department of Genetics, University of Washington, Seattle 98195, USA
    Genetics 147:1675-95. 1997
    ..Our analysis of these suppressors suggests that the majority of these genes are part of a shared lin-12/glp-1 signal transduction pathway, or act to regulate the expression or stability of lin-12 and glp-1...
  68. pmc emo-1, a Caenorhabditis elegans Sec61p gamma homologue, is required for oocyte development and ovulation
    K Iwasaki
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 134:699-714. 1996
    ..We propose that the emo-1 gene product acts in the transport of secreted and transmembrane proteins in C. elegans oocytes, and is necessary for both oogenesis and the coupling of ovulation with meiotic maturation...
  69. ncbi Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
    D Levitan
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Nature 377:351-4. 1995
    ..The high degree of sequence conservation suggests that the function of the SEL-12 and S182 proteins may also be conserved...
  70. pmc Temporal control of cell-specific transgene expression in Caenorhabditis elegans
    Taulant Bacaj
    Laboratory of Developmental Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Genetics 176:2651-5. 2007
    ..We demonstrate the utility of this method for timed reporter gene expression and for temporal studies of gene function...
  71. ncbi The C. elegans Mi-2 chromatin-remodelling proteins function in vulval cell fate determination
    T von Zelewsky
    Institute of Zoology, Department of Biology, University of Fribourg, Perolles, CH 1700 Fribourg, Switzerland
    Development 127:5277-84. 2000
    ....
  72. ncbi Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos
    B Etemad-Moghadam
    Section of Genetics and Development, Cornell University, Ithaca, New York 14853, USA
    Cell 83:743-52. 1995
    ..In addition, the distribution of the PAR-3 protein correlates with differences in cleavage spindle orientation and suggests a mechanism by which PAR-3 contributes to control of cleavage pattern...
  73. ncbi The forkhead gene family of Caenorhabditis elegans
    Ian A Hope
    School of Biology, University of Leeds, Leeds LS2 9JT, UK
    Gene 304:43-55. 2003
    ..elegans. Comparisons of expression patterns and RNAi/mutant phenotypes for all 15 C. elegans forkhead genes reveal the potential complexity of functional interactions for this gene family...
  74. pmc Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway
    Dasa Longman
    Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, Scotland, United Kingdom
    Genes Dev 21:1075-85. 2007
    ..elegans that we have termed smgl (for smg lethal). We show that the encoded proteins are conserved throughout evolution and are required for NMD in C. elegans and also in human cells...
  75. ncbi A C. elegans orphan nuclear receptor contributes to xenobiotic resistance
    T H Lindblom
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    Curr Biol 11:864-8. 2001
    ..We conclude that NHR-8 functions in the nematode xenobiotic defense system and that NHR-8 and PGP-3 have overlapping, but distinct, spectra of toxin specificity...
  76. ncbi Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans
    Hannes Lans
    MGC Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Dev Biol 303:474-82. 2007
    ..We expect that the implication of specific G proteins will eventually contribute to the identification of the sensory cues that determine the rate of aging in C. elegans...
  77. ncbi A cDNA encoding Tc-MUC-5, a mucin from Toxocara canis larvae identified by expression screening
    A Doedens
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, EH9 3JT, Edinburgh, UK
    Acta Trop 79:211-7. 2001
    ..7%), suggesting that this protein is not part of the TES-120 family of surface coat proteins...
  78. ncbi Binary specification of the embryonic lineage in Caenorhabditis elegans
    T Kaletta
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Nature 390:294-8. 1997
    ..Most blastomere identities in C. elegans may therefore stem from a process of stepwise binary diversification...
  79. ncbi A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans
    S Guo
    Section of Genetics and Development, Cornell University, Ithaca, New York 14853, USA
    Nature 382:455-8. 1996
    ..We therefore conclude the NMY-2 is required for establishing cellular polarity in C. elegans embryos...
  80. ncbi Molecular analysis of nematode diversity and the evolution of parasitism
    M Dorris
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, UK
    Parasitol Today 15:188-93. 1999
    ....
  81. ncbi Systemic RNAi in C. elegans requires the putative transmembrane protein SID-1
    William M Winston
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 295:2456-9. 2002
    ..One of these loci, sid-1, encodes a conserved protein with predicted transmembrane domains. SID-1 is expressed in cells sensitive to RNAi, is localized to the cell periphery, and is required cell-autonomously for systemic RNAi...
  82. ncbi EGL-38 Pax regulates the ovo-related gene lin-48 during Caenorhabditis elegans organ development
    A D Johnson
    Department of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA
    Development 128:2857-65. 2001
    ..These experiments demonstrate a functional link between Pax and Ovo transcription factors, and provide a model for how Pax transcription factors can regulate different target genes in different cells...
  83. ncbi Evolution of the Caenorhabditis elegans genome
    Asher D Cutter
    Department of Ecology and Evolutionary Biology and the Centre for the Analysis of Genome Evolution and Function, University of Toronto, Toronto, Ontario, Canada
    Mol Biol Evol 26:1199-234. 2009
    ..We also emphasize the potential importance of evolution in the gonochoristic (female and male) ancestors of the androdioecious (hermaphrodite and male) C. elegans as the source for many of its genomic and developmental patterns...
  84. pmc A role for autophagy in the extension of lifespan by dietary restriction in C. elegans
    Malene Hansen
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
    PLoS Genet 4:e24. 2008
    ....
  85. ncbi The Kallmann syndrome gene homolog in C. elegans is involved in epidermal morphogenesis and neurite branching
    Elena I Rugarli
    Telethon Institute of Genetics and Medicine TIGEM, via P Castellino III, 80131 Naples, Italy
    Development 129:1283-94. 2002
    ..Our findings add a new player to the set of molecules, which appear to underlie both morphogenesis and axonal/neuronal navigation in vertebrates and invertebrates...
  86. ncbi A single gene network accurately predicts phenotypic effects of gene perturbation in Caenorhabditis elegans
    Insuk Lee
    Center for Systems and Synthetic Biology, Department of Chemistry and Biochemistry, Institute for Cellular and Molecular Biology, University of Texas, 2500 Speedway, MBB 3 210, Austin, Texas 78712, USA
    Nat Genet 40:181-8. 2008
    ..We conclude that an analogous network for human genes might be similarly predictive and thus facilitate identification of disease genes and rational therapeutic targets...
  87. ncbi Transcriptional profile of aging in C. elegans
    James Lund
    Department of Developmental Biology, Stanford University Medical Center, Stanford, CA 94305, USA
    Curr Biol 12:1566-73. 2002
    ..Several distinct mechanisms including an altered rate of aging, increased resistance to stress, decreased metabolic rate, or alterations in a program causing organismic aging and death have been proposed to underlie these mutants...
  88. pmc Fat metabolism links germline stem cells and longevity in C. elegans
    Meng C Wang
    Department of Molecular Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Science 322:957-60. 2008
    ..This lipase is a key factor in the lipid hydrolysis and increased longevity that are induced by decreased insulin signaling. These results suggest a link between C. elegans fat metabolism and longevity...
  89. pmc Identification of genes needed for regeneration, stem cell function, and tissue homeostasis by systematic gene perturbation in planaria
    Peter W Reddien
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, 84132, USA
    Dev Cell 8:635-49. 2005
    ....
  90. pmc Hormesis and aging in Caenorhabditis elegans
    James R Cypser
    University of Colorado, Institute for Behavioral Genetics, Box 447 Boulder, CO 80309, Fedex, 1480 30th St, Boulder, CO 80303, USA
    Exp Gerontol 41:935-9. 2006
    ..Mutations in three other genes of this pathway (daf-3, daf-5, and age-1) do not block induced life extension or induced thermotolerance; daf-5 mutants may be unusually sensitive to hormetic conditions...
  91. pmc A compendium of Caenorhabditis elegans regulatory transcription factors: a resource for mapping transcription regulatory networks
    John S Reece-Hoyes
    Institute of Integrative and Comparative Biology, Faculty of Biological Sciences, School of Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK
    Genome Biol 6:R110. 2005
    ....
  92. ncbi A conserved RNA-binding protein controls germline stem cells in Caenorhabditis elegans
    Sarah L Crittenden
    Howard Hughes Medical Institute, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nature 417:660-3. 2002
    ..We suggest that regulation by PUF proteins may be an ancient and widespread mechanism for control of stem cells...
  93. pmc The role of lineage-specific gene family expansion in the evolution of eukaryotes
    Olivier Lespinet
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Genome Res 12:1048-59. 2002
    ..LSEs seem to be one of the principal means of adaptation and one of the most important sources of organizational and regulatory diversity in crown-group eukaryotes...
  94. ncbi Control of C. elegans larval development by neuronal expression of a TGF-beta homolog
    P Ren
    Molecular Biology Program and Division of Biological Sciences, 311 Tucker Hall, University of Missouri, Columbia, MO 65211, USA
    Science 274:1389-91. 1996
    ..When the food/pheromone ratio is high, the level of daf-7 mRNA peaks during the L1 larval stage, when commitment to non-dauer development is made...
  95. pmc Prolyl 4-hydroxylase is an essential procollagen-modifying enzyme required for exoskeleton formation and the maintenance of body shape in the nematode Caenorhabditis elegans
    A D Winter
    Wellcome Centre for Molecular Parasitology, Anderson College, The University of Glasgow, Glasgow G11 6NU, United Kingdom
    Mol Cell Biol 20:4084-93. 2000
    ..This study demonstrates in vivo that this enzyme complex plays a central role in extracellular matrix formation and is essential for normal metazoan development...
  96. ncbi RNAi from plants to nematodes
    Godelieve Gheysen
    Department of Molecular Biotechnology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium
    Trends Biotechnol 25:89-92. 2007
    ..Recent work has demonstrated that the expression in a host plant of double-stranded RNA targeting housekeeping or parasitism genes in the root-knot nematode resulted in resistance to nematode infection...
  97. pmc Functional genomics of hsp-90 in parasitic and free-living nematodes
    Victoria Gillan
    Parasitology Group, Division of Infection and Immunity, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK
    Int J Parasitol 39:1071-81. 2009
    ..These results indicate that factors other than the level of sequence identity are important for determining whether parasite genes can functionally complement in C. elegans...
  98. pmc Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system
    M Maduro
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    Genetics 141:977-88. 1995
    ..Expression of an unc-119/lacZ fusion in transgenic animals is seen in many neurons, suggesting that the unc-119 mutant phenotype is due to a defect in the nervous system...
  99. ncbi Ectopic expression of a Haemonchus contortus GATA transcription factor in Caenorhabditis elegans reveals conserved function in spite of extensive sequence divergence
    Annabelle Couthier
    Department of Veterinary Parasitology, Faculty of Veterinary Medicine, Institute of Comparative Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, UK
    Mol Biochem Parasitol 133:241-53. 2004
    ..This approach of ectopic expression using an inducible promoter provides an effective way in which to use C. elegans for the in vivo functional analysis of parasitic nematode genes...
  100. ncbi Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease
    T E Johnson
    Institute for Behavioral Genetics, University of Colorado at Boulder, 80309, USA
    J Inherit Metab Dis 25:197-206. 2002
    ..In mammals, both dietary restriction and hormesis are phenomena in which the endogenous level of resistance to stress has been upregulated; both of these interventions extend longevity, suggesting possible evolutionary conservation...

Research Grants59

  1. NEURAL CONTROL OF A MOTOR PROGRAM
    James Thomas; Fiscal Year: 2002
    ..We will also continue genetic screens to identify additional potential targets. ..
  2. GENETIC ANALYSIS OF CHEMOSENSATION IN C ELEGANS
    James Thomas; Fiscal Year: 2003
    ..All of the pathways under study here correspond to important regulatory pathways in humans, and many of the genes are affected in various inherited disorders. ..
  3. Proteogenomic Analysis of C. elegans
    James Thomas; Fiscal Year: 2007
    ..elegans proteome and a high-throughput pipeline that will allow similar analysis of any complex animal or plant proteome whose genome sequence is available. [unreadable] [unreadable] [unreadable]..
  4. MARINER TRANSPOSONS OF MAMMALS
    Hugh Robertson; Fiscal Year: 2001
    ..It will also reveal how occasionally particular copies of transposons can become integral parts of their host genetic complements. ..
  5. Gustatory and olfactory receptors of Anopheles gambiae
    Hugh Robertson; Fiscal Year: 2006
    ..This work will also contribute to our overall understanding of the molecular basis of chemoreception in insects and other animals. [unreadable] [unreadable]..
  6. Functional Genomics:Complex Biological Systems
    Stuart Kim; Fiscal Year: 2003
    ..The goal of the meeting is to integrate advances in human disease, modeling of genetic networks, quantitative trait mapping, and data mining techniques. ..
  7. 2001 International C. elegans Meeting
    Paul Sternberg; Fiscal Year: 2001
    ..Previous C. elegans meetings have led to the exchange of knowledge, ideas, methods, mutants, and clones, and have been vital in fostering the sense of excitement, collegiality and cooperativity that characterize this field. ..
  8. Tissue Fragility genes in C. elegans
    John Plenefisch; Fiscal Year: 2005
    ..abstract_text> ..
  9. REGULATION OF GENE EXPRESSION DURING ORGANOGENESIS
    Helen Chamberlin; Fiscal Year: 2004
    ..elegans. A third aim is to functionally characterize this second gene to determine whether its product shares in vivo functions with EGL-38, or whether it regulates lin-48 and cdh-3 expression in other organs. ..
  10. MAP kinase signal specificity in the C. elegans germline
    Valerie Reinke; Fiscal Year: 2007
    ..Together these experiments should build toward a comprehensive understanding of the mechanisms used to produce a specific cell fate in response to a generally used signaling pathway. ..
  11. Development of a novel nematode/Wolbachia target
    Clotilde Carlow; Fiscal Year: 2007
    ..This will provide the basis for discovering a new class of drugs that may be used in veterinary and human medicine. [unreadable] [unreadable]..
  12. A GENOMIC APPROACH TO PARASITES FROM THE PHYLUM NEMATODA
    Makedonka Mitreva; Fiscal Year: 2007
    ..Working with collaborators, a limited number of novel domains will be characterized in more detail with an emphasis on postulating molecular or cellular function. ..
  13. PROTEOMIC ANALYSIS OF DECREASED AUTOPHAGY IN AGING
    Ana Cuervo; Fiscal Year: 2005
    ..abstract_text> ..
  14. Cell Type Specific Regulators of Cell Death
    John Cameron; Fiscal Year: 2006
    ..In this way I will use the extraordinarily powerful methods available in C. elegans for analysis of how mutations affect cell fates to test models of how mutant mammalian genes are oncogenic. ..
  15. CYSTEINE PROTEASES & INHIBITORS IN NEMATODE DEVELOPMENT
    Sara Lustigman; Fiscal Year: 2005
    ..This will provide the basis for developing effective drugs, targeting cysteine proteases, to control onchocerciasis and filariasis in the future. ..
  16. DYNAMICS AND FUNCTION OF G4 DNA
    Nancy Maizels; Fiscal Year: 2007
    ..abstract_text> ..
  17. STAGE and FAIRE for Regulatory Element Identification
    Vishwanath Iyer; Fiscal Year: 2006
    ..abstract_text> ..
  18. Gamete Interactions in Caenorhabditis elegans
    Andrew Singson; Fiscal Year: 2007
    ..This work will complement fertility studies in other organisms as well as provide insights into the mechanisms of cell-cell interactions and the diversity of reproductive strategies. [unreadable] [unreadable] [unreadable]..
  19. Variation of D. melanogaster chromosome 4
    Manyuan Long; Fiscal Year: 2006
    ..These studies should add significantly to the understanding of the evolutionary genetics of the Drosophila fourth chromosome. ..
  20. Cytokinesis and the Cytoskeleton in C. elegans Embryos
    BRUCE A BOWERMAN; Fiscal Year: 2010
    ..Matthias Peter at the ETH in Zurich, Switzerland. The processes and genes we propose to investigate are relevant to important human diseases, including cancer and neurodegenerative disease. ..
  21. Lifespan determination and stress response in C. elegans
    Gordon Lithgow; Fiscal Year: 2006
    ..Thirdly, we will identify and manipulate the levels of endocrine signals that act downstream of the insulin/IGF signaling pathway to limit lifespan. ..
  22. Detection of Distribution of New Genes in Drosophila Phylogeny
    MANYUAN NO LONG; Fiscal Year: 2010
    ..The results from these four categories of studies will generate the first phylogenetic distribution of new genes and provide the fresh-insight into the rates and patterns of new gene originations in genomes. ..
  23. A Helminth-Derived Immune Potentiator for Biodefense
    Sara Lustigman; Fiscal Year: 2006
    ..abstract_text> ..
  24. Regulation and Function of Hox gene lin-39 in C elegans
    DAVID EISENMANN; Fiscal Year: 2007
    ..elegans, for which full genomic sequence is available and functional genomic approaches are available. ..
  25. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  26. MOLECULAR MECHANISMS OF ISOTYPE SWITCH RECOMBINATION
    Nancy Maizels; Fiscal Year: 2009
    ..abstract_text> ..
  27. Temperature Sensation and Its Behavioral Consequences
    MIRIAM GOODMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. Trans-splicing in C. elegans
    Thomas Blumenthal; Fiscal Year: 2007
    ..We will determine what functions these proteins have in 3' end formation. These studies should provide important new insight into how 3' end cleavage can occur without accompanying transcription termination. ..
  29. Vaccine induced resistance against E. granulosus in dogs
    Wenbao Zhang; Fiscal Year: 2007
    ..granulosus infection by vaccination with the recombinant proteins. We will test humoral and cellular responses generated during vaccination to determine possible correlations of the immune parameters with protection. ..
  30. Gene networks specifying cell lineages in a polychaete
    Bruce Bowerman; Fiscal Year: 2007
    ..Newly discovered and conserved loci will also be studied in C. elegans and Drosophila. [unreadable] [unreadable]..
  31. Comparative Biology of p53, Checkpoint and Longevity
    Gordon Lithgow; Fiscal Year: 2007
    ..As these factors appear to affect aging in both simple invertebrates and mammals, we expect to define broad mechanisms by which cellular and organismal aging are co-regulated. ..
  32. PROTECTIVE IMMUNITY IN HUMANS AGAINST O VOLVULUS LARVAE
    Sara Lustigman; Fiscal Year: 2001
    ..These studies should, therefore, be instrumental in developing a vaccine against onchocerciasis with anticipated clinical application. ..
  33. Control of cell polarity in the C. elegans zygote
    Geraldine Seydoux; Fiscal Year: 2005
    ..We anticipate that our studies will provide significant insights into these processes by taking advantage of the experimental attributes of a simple model system...
  34. C. elegans, Aging and High Throughput Screening (RMI)
    Gordon Lithgow; Fiscal Year: 2004
    ..elegans for HTS. Our longer term goal is to undertake HTS for compounds that protect against oxidative stress, extend lifespan and translate into mammalian models of age-related diseases such as Alzheimer's and Parkinson's. ..
  35. Isolation of src-like signaling components
    LISA MADUZIA; Fiscal Year: 2005
    ..abstract_text> ..
  36. Gordon Research Conference, Biology of Aging, 2004
    Gordon Lithgow; Fiscal Year: 2004
    ..abstract_text> ..
  37. MITOCHONDRIAL OXIDATIVE STRESS AND NEURODEGENERATION
    Simon Melov; Fiscal Year: 2004
    ....
  38. Fluorescent Activated Cell Sorter for C. elegans (worms)
    Susan Mango; Fiscal Year: 2004
    ..elegans researchers at the University of Utah. It would both facilitate existing research projects and permit the development of new projects that could not function without this novel instrument. ..
  39. 2003/2005 INTERNATIONAL C. ELEGANS MEETINGS
    Geraldine Seydoux; Fiscal Year: 2004
    ..Previous C. elegans meetings have led to the exchange of knowledge, ideas, methods, mutants, and clones and have been vital in fostering the sense of excitement and the collegiality and cooperativity that characterize this field. ..
  40. SEQUENCING THE MOUSE GENOME
    Richard Wilson; Fiscal Year: 2004
    ..This sequence information will be an invaluable tool for gene discovery and annotation of the mouse and human genomes. ..
  41. Function of a Neuropeptide Gene Family in C. elegans
    Christine Li; Fiscal Year: 2006
    ..In addition, because C. elegans is the current genetic model system for parasitic nematodes, elucidating the functions of neuropeptides and their signaling pathways may identify new antihelmintic drug targets. ..
  42. Comparative Functional Genomics of Longevity Assurance
    Simon Melov; Fiscal Year: 2006
    ..In years four and five we will apply the functional genomic approach defined above, as well as statistical methods refined during the first three years, to the analysis of mouse RI lines with differential lifespans. ..
  43. Gordon Conference-Autophagy/Stress/Development/Disease
    Ana Cuervo; Fiscal Year: 2007
    ....
  44. Regulation of Programmed Cell Death in C.elegans
    John Cameron; Fiscal Year: 2008
    ..elegans ventral nerve cord. We will use RNAi to screen 25 candidate genes and identify those that act with lin-59 to promote survival of the VC motor neurons. ..
  45. REGULATION OF SPLICE SITE CHOICE IN C. ELEGANS
    ALAN ZAHLER; Fiscal Year: 2009
    ..3- To characterize suppressors of 5'and 3'splice site defects in order to illuminate the mechanisms of splice site selection. ..
  46. Genetic Regulation of Mating Behavior in C. elegan Males
    Luis Garcia; Fiscal Year: 2009
    ..Additionally, this project will identify components of activating pathways that must be attenuated by unc-103 during periods between mating. ..
  47. daf-12 Target Genes during C. elegans aging
    Alfred Fisher; Fiscal Year: 2005
    ..abstract_text> ..
  48. Control of nematode development
    Eric Lambie; Fiscal Year: 2005
    ..Therefore, the results of this work are likely to be highly significant with regard to the etiology of human disease. ..
  49. INDYs: A Link between Membrane Transport and Life Span
    Vadivel Ganapathy; Fiscal Year: 2006
    ..abstract_text> ..
  50. PROBABILISTIC MODELS OF PROTEIN AND RNA STRUCTURE
    Sean Eddy; Fiscal Year: 2006
    ..A final aim proposes a method for identifying the mRNA targets of regulatory RNAs (such as the newly discovered micro RNAs) by comparative genome analysis. ..
  51. RNAi Mediated Gene Disruption in Caenorhabditis Elegans
    Wayne Van Voorhies; Fiscal Year: 2006
    ..Such worms could identify candidate genes affecting processes that act "downstream" from the metabolic rate and provide valuable insights into the causes of aging and mechanisms by which it can be attenuated. ..
  52. Gamete Interactions in Caenorhabditis elegans
    Andrew Singson; Fiscal Year: 2005
    ..This work will provide new insight into cell-cell interactions, conception and complement studies of fertilization in other organisms. ..
  53. Genetic Dissection of Sickle Cell Anemia Phenotypes
    Paola Sebastiani; Fiscal Year: 2006
    ..abstract_text> ..
  54. Regulation of Innate Immunity by Virulence Factors
    Alejandro Aballay; Fiscal Year: 2006
    ..elegans. 3) Elucidate the mechanism by which the genes identified in Aims 1 and 2 contribute to C. elegans innate immunity pathways conserved in mammals. ..
  55. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  56. Conference on Genome Instability and Repair
    Nancy Maizels; Fiscal Year: 2005
    ..The molecular and mechanistic emphasis on pathways critical for genomic stability in a variety of biological contexts is designed to attract a unique audience of researchers at this interface. ..
  57. Genetic Control of Development in C elegans
    Stuart Kim; Fiscal Year: 2006
    ..abstract_text> ..
  58. TELOMERES OF BDELLOID AND MONOGONONT ROTIFERS
    Matthew Meselson; Fiscal Year: 2007
    ..As telomeres are involved in diverse pathologies, including metastatic growth, the results of the proposed study may provide insight into mechanisms and possible therapies of importance. ..