multigene family

Summary

Summary: A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)

Top Publications

  1. ncbi The amphioxus genome and the evolution of the chordate karyotype
    Nicholas H Putnam
    Department of Energy Joint Genome Institute, Walnut Creek, California 94598, USA
    Nature 453:1064-71. 2008
  2. ncbi Genome sequence of the palaeopolyploid soybean
    Jeremy Schmutz
    HudsonAlpha Genome Sequencing Center, 601 Genome Way, Huntsville, Alabama 35806, USA
    Nature 463:178-83. 2010
  3. pmc Prospects for inferring very large phylogenies by using the neighbor-joining method
    Koichiro Tamura
    Center for Evolutionary Functional Genomics, The Biodesign Institute, Arizona State University, Tempe, 85287 4501, USA
    Proc Natl Acad Sci U S A 101:11030-5. 2004
  4. ncbi A microRNA polycistron as a potential human oncogene
    Lin He
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 435:828-33. 2005
  5. ncbi Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
    S D Bentley
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 417:141-7. 2002
  6. ncbi Initial sequencing and comparative analysis of the mouse genome
    Robert H Waterston
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 420:520-62. 2002
  7. pmc Genome-wide analysis of the ERF gene family in Arabidopsis and rice
    Toshitsugu Nakano
    Molecular and Cellular Breeding Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8566, Japan
    Plant Physiol 140:411-32. 2006
  8. ncbi Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
    Ravi S Kamath
    Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Nature 421:231-7. 2003
  9. ncbi The JAZ family of repressors is the missing link in jasmonate signalling
    A Chini
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma, 28049 Madrid, Spain
    Nature 448:666-71. 2007
  10. ncbi Identification of novel genes coding for small expressed RNAs
    M Lagos-Quintana
    Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, , Germany
    Science 294:853-8. 2001

Research Grants

Detail Information

Publications316 found, 100 shown here

  1. ncbi The amphioxus genome and the evolution of the chordate karyotype
    Nicholas H Putnam
    Department of Energy Joint Genome Institute, Walnut Creek, California 94598, USA
    Nature 453:1064-71. 2008
    ..These genome-scale events shaped the vertebrate genome and provided additional genetic variation for exploitation during vertebrate evolution...
  2. ncbi Genome sequence of the palaeopolyploid soybean
    Jeremy Schmutz
    HudsonAlpha Genome Sequencing Center, 601 Genome Way, Huntsville, Alabama 35806, USA
    Nature 463:178-83. 2010
    ..An accurate soybean genome sequence will facilitate the identification of the genetic basis of many soybean traits, and accelerate the creation of improved soybean varieties...
  3. pmc Prospects for inferring very large phylogenies by using the neighbor-joining method
    Koichiro Tamura
    Center for Evolutionary Functional Genomics, The Biodesign Institute, Arizona State University, Tempe, 85287 4501, USA
    Proc Natl Acad Sci U S A 101:11030-5. 2004
    ..Our results encourage the use of complex models of nucleotide substitution for estimating evolutionary distances and hint at bright prospects for the application of the NJ and related methods in inferring large phylogenies...
  4. ncbi A microRNA polycistron as a potential human oncogene
    Lin He
    Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 435:828-33. 2005
    ..Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene...
  5. ncbi Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
    S D Bentley
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nature 417:141-7. 2002
    ..The genome sequence will greatly increase our understanding of microbial life in the soil as well as aiding the generation of new drug candidates by genetic engineering...
  6. ncbi Initial sequencing and comparative analysis of the mouse genome
    Robert H Waterston
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 420:520-62. 2002
    ....
  7. pmc Genome-wide analysis of the ERF gene family in Arabidopsis and rice
    Toshitsugu Nakano
    Molecular and Cellular Breeding Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki 305 8566, Japan
    Plant Physiol 140:411-32. 2006
    ..These results will be useful for future functional analyses of the ERF family genes...
  8. ncbi Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
    Ravi S Kamath
    Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Nature 421:231-7. 2003
    ..Our resulting data set and reusable RNAi library of 16,757 bacterial clones will facilitate systematic analyses of the connections among gene sequence, chromosomal location and gene function in C. elegans...
  9. ncbi The JAZ family of repressors is the missing link in jasmonate signalling
    A Chini
    Departamento de Genética Molecular de Plantas, Centro Nacional de Biotecnologia CSIC, Campus Universidad Autonoma, 28049 Madrid, Spain
    Nature 448:666-71. 2007
    ..Furthermore, we demonstrate the existence of a regulatory feed-back loop involving MYC2 and JAZ proteins, which provides a mechanistic explanation for the pulsed response to jasmonate and the subsequent desensitization of the cell...
  10. ncbi Identification of novel genes coding for small expressed RNAs
    M Lagos-Quintana
    Department of Cellular Biochemistry, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, , Germany
    Science 294:853-8. 2001
    ..This suggests that sequence-specific, posttranscriptional regulatory mechanisms mediated by small RNAs are more general than previously appreciated...
  11. pmc The roles of segmental and tandem gene duplication in the evolution of large gene families in Arabidopsis thaliana
    Steven B Cannon
    Plant Biology Department, University of Minnesota, St, Paul, MN 55108, USA
    BMC Plant Biol 4:10. 2004
    ....
  12. ncbi The genome sequence of the filamentous fungus Neurospora crassa
    James E Galagan
    Whitehead Institute Center for Genome Research, 320 Charles Street, Cambridge, Massachusetts 02141, USA
    Nature 422:859-68. 2003
    ..Genome analysis suggests that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes...
  13. ncbi The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes
    Helen Skaletsky
    Howard Hughes Medical Institute, Whitehead Institute, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 423:825-37. 2003
    ..9% identity, which is maintained by frequent gene conversion (non-reciprocal transfer). The most prominent features here are eight massive palindromes, at least six of which contain testis genes...
  14. ncbi An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
    N C Lau
    Whitehead Institute for Biomedical Research, and Department of Biology, Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 294:858-62. 2001
    ..The abundance of these tiny RNAs, their expression patterns, and their evolutionary conservation imply that, as a class, miRNAs have broad regulatory functions in animals...
  15. ncbi The functions of animal microRNAs
    Victor Ambros
    Dartmouth Medical School, Department of Genetics, Hanover, New Hampshire 03755, USA E mail
    Nature 431:350-5. 2004
    ....
  16. pmc A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes
    Daniel H Haft
    The Institute for Genomic Research, Rockville, Maryland, USA
    PLoS Comput Biol 1:e60. 2005
    ..It is evident from this analysis that CRISPR/cas loci are larger, more complex, and more heterogeneous than previously appreciated...
  17. pmc Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters
    Andrea Ventura
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 132:875-86. 2008
    ..These results provide key insights into the physiologic functions of this family of microRNAs and suggest a link between the oncogenic properties of miR-17 approximately 92 and its functions during B lymphopoiesis and lung development...
  18. ncbi A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
    Thorgeir E Thorgeirsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nature 452:638-42. 2008
    ..The findings provide a case study of a gene-environment interaction, highlighting the role of nicotine addiction in the pathology of other serious diseases...
  19. pmc Concerted and birth-and-death evolution of multigene families
    Masatoshi Nei
    Institute of Molecular Evolutionary Genetics and Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Annu Rev Genet 39:121-52. 2005
    ..Unlike concerted evolution, the model of birth-and-death evolution can give some insights into the origins of new genetic systems or new phenotypic characters...
  20. ncbi The R2R3-MYB gene family in Arabidopsis thaliana
    R Stracke
    Max Planck Institute for Plant Breeding Research, Carl von Linne Weg 10, D 50829, Koln, Germany
    Curr Opin Plant Biol 4:447-56. 2001
    ..R2R3-type MYB genes control many aspects of plant secondary metabolism, as well as the identity and fate of plant cells...
  21. pmc Comparative genomics of the neglected human malaria parasite Plasmodium vivax
    Jane M Carlton
    The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Nature 455:757-63. 2008
    ..Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species...
  22. pmc The Chlamydomonas genome reveals the evolution of key animal and plant functions
    Sabeeha S Merchant
    Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 318:245-50. 2007
    ....
  23. ncbi Soluble proteins in insect chemical communication
    P Pelosi
    Dipartimento di Chimica e Biotecnologie Agrarie, University of Pisa Italy, Agrarie via S Michele, 4, 56124, Pisa, Italy
    Cell Mol Life Sci 63:1658-76. 2006
    ..Finally, we discuss current ideas and models of the role of such proteins in insect chemoreception...
  24. ncbi Homeobox genes and axial patterning
    W McGinnis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 68:283-302. 1992
  25. ncbi G protein-coupled receptors in Anopheles gambiae
    Catherine A Hill
    Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
    Science 298:176-8. 2002
    ..Examples of lineage-specific gene expansions were observed as well as a single instance of unusually high sequence conservation...
  26. pmc Horizontal transfer, not duplication, drives the expansion of protein families in prokaryotes
    Todd J Treangen
    Institut Pasteur, Microbial Evolutionary Genomics, Département Génomes et Génétique, Paris, France
    PLoS Genet 7:e1001284. 2011
    ..Therefore, the study of the evolution of biology systems should explicitly account for the predominant role of horizontal gene transfer in the diversification of protein families...
  27. pmc Unraveling ancient hexaploidy through multiply-aligned angiosperm gene maps
    Haibao Tang
    Plant Genome Mapping Laboratory, University of Georgia, Athens, Georgia 30602, USA
    Genome Res 18:1944-54. 2008
    ..Comparative analysis of inferred homologous genes derived from this model shows patterns of preferential gene retention or loss after polyploidy and reveals large variability of nucleotide substitution rates among plant nuclear genomes...
  28. ncbi Evolution of genes and genomes on the Drosophila phylogeny
    Andrew G Clark
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 450:203-18. 2007
    ..These may prove to underlie differences in the ecology and behaviour of these diverse species...
  29. pmc Genome-wide analysis of NBS-LRR-encoding genes in Arabidopsis
    Blake C Meyers
    Department of Vegetable Crops, University of California, Davis, California 95616, USA
    Plant Cell 15:809-34. 2003
    ..The observed diversity of these NBS-LRR proteins indicates the variety of recognition molecules available in an individual genotype to detect diverse biotic challenges...
  30. pmc Comparative analysis of the receptor-like kinase family in Arabidopsis and rice
    Shin Han Shiu
    Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA
    Plant Cell 16:1220-34. 2004
    ..These findings led us to hypothesize that most of the recent expansions of the RLK/Pelle family have involved defense/resistance-related genes...
  31. ncbi Evolution of supergene families associated with insecticide resistance
    Hilary Ranson
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Science 298:179-81. 2002
    ..The analyses also provide the means for identifying previously unknown molecules involved in fundamental biological processes such as development...
  32. ncbi An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing
    L A Pennacchio
    Genome Sciences Department, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Science 294:169-73. 2001
    ..These findings indicate that APOAV is an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease...
  33. ncbi Enrichment or depletion of a GO category within a class of genes: which test?
    Isabelle Rivals
    Equipe de Statistique Appliquée, 10 rue Vauquelin, 75005 Paris, France
    Bioinformatics 23:401-7. 2007
    ..Whereas a correct formulation of the problem leads to a single exact null distribution, these GO tools use a large variety of statistical tests whose denominations often do not clarify the underlying P-value computations...
  34. pmc A genome-wide characterization of microRNA genes in maize
    Lifang Zhang
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
    PLoS Genet 5:e1000716. 2009
    ..As maize is one of the principal models for plant growth and development, this study will serve as a foundation for future research into the functional roles of miRNA genes...
  35. ncbi Modulating Hox gene functions during animal body patterning
    Joseph C Pearson
    Section in Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA
    Nat Rev Genet 6:893-904. 2005
    ..Finally, the recent discovery of microRNA genes within the Hox gene clusters indicates yet another level of control by Hox genes in development and evolution...
  36. ncbi MicroRNA expression in zebrafish embryonic development
    Erno Wienholds
    Hubrecht Laboratory, Centre for Biomedical Genetics, 3584 CT Utrecht, The Netherlands
    Science 309:310-1. 2005
    ....
  37. pmc Evolutionary analysis of Arabidopsis, cyanobacterial, and chloroplast genomes reveals plastid phylogeny and thousands of cyanobacterial genes in the nucleus
    William Martin
    Institut fur Botanik, Heinrich Heine Universitat, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Proc Natl Acad Sci U S A 99:12246-51. 2002
    ....
  38. pmc The Pfam protein families database
    Alex Bateman
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Nucleic Acids Res 32:D138-41. 2004
    ..Pfam is available on the web in the UK (http://www.sanger.ac.uk/Software/Pfam/), the USA (http://pfam.wustl.edu/), France (http://pfam.jouy.inra.fr/) and Sweden (http://Pfam.cgb.ki.se/)...
  39. pmc Dissecting the bacterial type VI secretion system by a genome wide in silico analysis: what can be learned from available microbial genomic resources?
    Frederic Boyer
    CEA, iRTSV, Laboratoire Biologie, Informatique et Mathématiques, Grenoble, France
    BMC Genomics 10:104. 2009
    ..By combining comparative and phylogenetic approaches using more than 500 prokaryotic genomes, we characterized the global T6SS genetic structure in terms of conservation, evolution and genomic organization...
  40. ncbi A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation
    Yoji Hayashita
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Japan
    Cancer Res 65:9628-32. 2005
    ....
  41. ncbi The MYB transcription factor superfamily of Arabidopsis: expression analysis and phylogenetic comparison with the rice MYB family
    Chen Yanhui
    Peking Yale Joint Center for Plant Molecular Genetics and Agrobiotechnology, National Key Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, 100871, Beijing, People s Republic of China
    Plant Mol Biol 60:107-24. 2006
    ..Our comprehensive analysis of this largest transcription factor superfamily of Arabidopsis and rice may help elucidate the possible biological roles of the MYB genes in various aspects of flowering plants...
  42. pmc LaeA, a regulator of secondary metabolism in Aspergillus spp
    Jin Woo Bok
    Department of Plant Pathology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Eukaryot Cell 3:527-35. 2004
    ....
  43. pmc Gene family evolution across 12 Drosophila genomes
    Matthew W Hahn
    Department of Biology, Indiana University, Bloomington, Indiana, United States of America
    PLoS Genet 3:e197. 2007
    ..It is likely that this genomic revolving door has played a large role in shaping the morphological, physiological, and metabolic differences among species...
  44. ncbi Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization
    Nicholas H Putnam
    Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA
    Science 317:86-94. 2007
    ..Analysis of diverse pathways suggests that these gene "inventions" along the lineage leading to animals were likely already well integrated with preexisting eukaryotic genes in the eumetazoan progenitor...
  45. pmc Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: insights into the pneumococcal supragenome
    N Luisa Hiller
    Allegheny General Hospital, Allegheny Singer Research Institute, Center for Genomic Sciences, Pittsburgh, PA 15212, USA
    J Bacteriol 189:8186-95. 2007
    ....
  46. ncbi Multidrug resistance in cancer: role of ATP-dependent transporters
    Michael M Gottesman
    Laboratory of Cell Biology and Cancer Therapeutics Branch, The Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Cancer 2:48-58. 2002
    ..Therefore, the ability to predict and circumvent drug resistance is likely to improve chemotherapy...
  47. pmc PLAZA: a comparative genomics resource to study gene and genome evolution in plants
    Sebastian Proost
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, B 9052 Ghent, Belgium
    Plant Cell 21:3718-31. 2009
    ..In conclusion, PLAZA provides a comprehensible and up-to-date research environment to aid researchers in the exploration of genome information within the green plant lineage...
  48. pmc Evolution of sensory complexity recorded in a myxobacterial genome
    B S Goldman
    Monsanto Company, St Louis, MO 63167, USA
    Proc Natl Acad Sci U S A 103:15200-5. 2006
    ..Families of genes encoding the production of secondary metabolites are overrepresented in the genome but may have been received by horizontal gene transfer and are likely to be important for predation...
  49. ncbi Genomic evolution of Hox gene clusters
    Derek Lemons
    Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA 92093, USA
    Science 313:1918-22. 2006
    ..Hox gene clusters also contain many noncoding RNAs, such as intergenic regulatory transcripts and evolutionarily conserved microRNAs, some of whose developmental functions have recently been explored...
  50. ncbi The natural history of nitrogen fixation
    Jason Raymond
    Department of Chemistry and Biochemistry, Arizona State University, Tempe, USA
    Mol Biol Evol 21:541-54. 2004
    ....
  51. ncbi Comprehensive analysis of NAC family genes in Oryza sativa and Arabidopsis thaliana
    Hisako Ooka
    Department of Molecular Genetics, National Institute of Agrobiological Sciences, 2 1 2 Kannon dai, Tsukuba, Ibaraki 305 8602, Japan
    DNA Res 10:239-47. 2003
    ..We discuss the relationship between the structure and function of the NAC family proteins in light of our results and the published data. Our results will aid further functional analysis of NAC family genes...
  52. pmc The chemical genomic portrait of yeast: uncovering a phenotype for all genes
    Maureen E Hillenmeyer
    Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA
    Science 320:362-5. 2008
    ..We found that 97% of gene deletions exhibited a measurable growth phenotype, suggesting that nearly all genes are essential for optimal growth in at least one condition...
  53. ncbi Horizontal transfer of a large and highly toxic secondary metabolic gene cluster between fungi
    Jason C Slot
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Curr Biol 21:134-9. 2011
    ..paperflick:..
  54. ncbi ABC transporters: from microorganisms to man
    C F Higgins
    Imperial Cancer Research Fund Laboratories, University of Oxford, John Radcliffe Hospital, England
    Annu Rev Cell Biol 8:67-113. 1992
  55. ncbi Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling
    Fabio Petrocca
    Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 68:8191-4. 2008
    ....
  56. ncbi Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism
    Eva Lattka
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Curr Opin Lipidol 21:64-9. 2010
    ..The present review summarizes the recent association studies on FADS genotypes and LC-PUFA levels and suggests ideas how FADS genotypes can be integrated in future research...
  57. ncbi The Physcomitrella genome reveals evolutionary insights into the conquest of land by plants
    Stefan A Rensing
    Plant Biotechnology, Faculty of Biology, University of Freiburg, Schaenzlestrasse 1, D 79104 Freiburg, Germany
    Science 319:64-9. 2008
    ..The Physcomitrella genome provides a resource for phylogenetic inferences about gene function and for experimental analysis of plant processes through this plant's unique facility for reverse genetics...
  58. pmc Common functions for diverse small RNAs of land plants
    Michael J Axtell
    Department of Biology and Huck Institutes of the Life Sciences, Pensylvania State University, University Park, PA 16802, USA
    Plant Cell 19:1750-69. 2007
    ..Diverse, lineage-specific, small RNAs can therefore perform common biological functions in plants...
  59. pmc Genome-wide analysis of the odorant-binding protein gene family in Drosophila melanogaster
    Daria S Hekmat-Scafe
    Department of Environmental Science, Policy and Management, Division of Insect Biology, University of California, Berkeley, California 94720, USA
    Genome Res 12:1357-69. 2002
    ..The sequence data from this study have been submitted to FlyBase. Annotations for these sequences are available as supplementary material at http://www.genome.org.]..
  60. pmc A chromatin landmark and transcription initiation at most promoters in human cells
    Matthew G Guenther
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 130:77-88. 2007
    ..These observations extend to differentiated cells, suggesting that transcription initiation at most genes is a general phenomenon in human cells...
  61. ncbi Type VI secretion is a major virulence determinant in Burkholderia mallei
    Mark A Schell
    Department of Microbiology, University of Georgia, Athens, GA 30602, USA
    Mol Microbiol 64:1466-85. 2007
    ..Purified His-tagged BMAA0742 was recognized by glanders antiserum from a horse, a human and mice, indicating that this Hcp-family protein is produced in vivo during infection...
  62. pmc Genome sequence of the streptomycin-producing microorganism Streptomyces griseus IFO 13350
    Yasuo Ohnishi
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    J Bacteriol 190:4050-60. 2008
    ..griseus...
  63. pmc Unraveling transcriptional control in Arabidopsis using cis-regulatory elements and coexpression networks
    Klaas Vandepoele
    Department of Plant Systems Biology, Flanders Institute for Biotechnology, B 9052 Ghent, Belgium
    Plant Physiol 150:535-46. 2009
    ....
  64. ncbi Fungal secondary metabolites - strategies to activate silent gene clusters
    Axel A Brakhage
    Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute HKI, Beutenbergstr 11a, 07745 Jena, Germany
    Fungal Genet Biol 48:15-22. 2011
    ..These simulation strategies will help discover new natural products in the future, and may also provide fundamental new insights into microbial communication...
  65. pmc Megabase level sequencing reveals contrasted organization and evolution patterns of the wheat gene and transposable element spaces
    Frédéric Choulet
    Institut National de la Recherche Agronomique, Universite Blaise Pascal, Unité Mixte de Recherche 1095 Genetics Diversity and Ecophysiology of Cereals, F 63100 Clermont Ferrand, France
    Plant Cell 22:1686-701. 2010
    ....
  66. ncbi Evolution of the Rab family of small GTP-binding proteins
    J B Pereira-Leal
    Cell and Molecular Biology Section, Division of Biomedical Sciences, Faculty of Medicine, Imperial College, London, SW7 2AZ, UK
    J Mol Biol 313:889-901. 2001
    ..Rab functional groups can help the understanding of the functional evolution of the Rab family in particular and vesicular transport in general, and may be used to predict general functions for novel Rab sequences...
  67. pmc Nitrogen fixation island and rhizosphere competence traits in the genome of root-associated Pseudomonas stutzeri A1501
    Yongliang Yan
    Biotechnology Research Institute, National Key Facility for Crop Gene Resources and Genetic Improvement, Chinese Academy of Agricultural Sciences, Beijing 100081, China
    Proc Natl Acad Sci U S A 105:7564-9. 2008
    ....
  68. pmc Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion
    Gabriele Bönemann
    Zentrum für Molekulare Biologie Heidelberg, DKFZ ZMBH Alliance, Universitat Heidelberg, Heidelberg, Germany
    EMBO J 28:315-25. 2009
    ..ClpV-mediated remodelling of VipA/VipB tubules represents a crucial step in T6S, illuminating an unexpected role of an ATPase component in protein secretion...
  69. pmc The Arabidopsis basic/helix-loop-helix transcription factor family
    Gabriela Toledo-Ortiz
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Plant Cell 15:1749-70. 2003
    ..These data are consistent, in principle, with the operation of this combinatorial mechanism in Arabidopsis...
  70. pmc The expansion of the metazoan microRNA repertoire
    Jana Hertel
    Bioinformatics Group, Department of Computer Science, University of Leipzig, Härtelstrasse 16 18, D 04107 Leipzig, Germany
    BMC Genomics 7:25. 2006
    ..This allows us to reliably identify microRNA clusters that are derived from a common transcript...
  71. ncbi Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression
    Igor N Zelko
    Division of Pulmonary and Critical Care, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 33:337-49. 2002
    ..A single amino acid mutation in human SOD3 is associated with 10 to 30-fold increases in serum SOD3 levels. As more information is obtained, further insights will be gained...
  72. ncbi Biosynthesis and mode of action of lantibiotics
    Champak Chatterjee
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, Illinois, USA
    Chem Rev 105:633-84. 2005
  73. pmc The genome of a songbird
    Wesley C Warren
    The Genome Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 464:757-62. 2010
    ..These results indicate an active involvement of the genome in neural processes underlying vocal communication and identify potential genetic substrates for the evolution and regulation of this behaviour...
  74. pmc STAMP: a web tool for exploring DNA-binding motif similarities
    Shaun Mahony
    Department of Computational Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Nucleic Acids Res 35:W253-8. 2007
    ..STAMP also directly accepts the output files from 12 supported motif-finders, enabling quick interpretation of motif-discovery analyses. STAMP is available at http://www.benoslab.pitt.edu/stamp...
  75. pmc Origins and evolution of microRNA genes in Drosophila species
    Masafumi Nozawa
    Institute of Molecular Evolutionary Genetics and Department of Biology, Pennsylvania State University, University Park, USA
    Genome Biol Evol 2:180-9. 2010
    ..Therefore, once miR genes acquired their functions, they appear to have evolved very slowly, maintaining essentially the same structures for a long time...
  76. pmc Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions
    Nicolaas C Gey van Pittius
    DST NRF Centre of Excellence in Biomedical Tuberculosis Research, Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Health Sciences, Stellenbosch University, Tygerberg, South Africa
    BMC Evol Biol 6:95. 2006
    ....
  77. pmc RTX proteins: a highly diverse family secreted by a common mechanism
    Irena Linhartova
    Institute of Microbiology AS CR v v i, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    FEMS Microbiol Rev 34:1076-112. 2010
    ....
  78. pmc Secondary metabolism in fungi: does chromosomal location matter?
    Jonathan M Palmer
    Plant Pathology Department, University of Wisconsin, Madison, WI 53706, USA
    Curr Opin Microbiol 13:431-6. 2010
    ..Secondary metabolite gene clusters are often located subtelomerically and recently it has been shown that proteins involved in chromatin remodeling, such as LaeA, ClrD, CclA, and HepA mediate cluster regulation...
  79. pmc Evolutionary history and stress regulation of plant receptor-like kinase/pelle genes
    Melissa D Lehti-Shiu
    Department of Plant Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Physiol 150:12-26. 2009
    ..Finally, we propose that the detection of highly variable molecular patterns associated with specific pathogens/parasites is the main reason for the up-regulation of hundreds of RLK/Pelles under biotic stress...
  80. pmc Expansion of the receptor-like kinase/Pelle gene family and receptor-like proteins in Arabidopsis
    Shin Han Shiu
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Plant Physiol 132:530-43. 2003
    ..Therefore, tandem duplications and segmental/whole-genome duplications represent two of the major mechanisms for the expansion of the RLK/Pelle family in Arabidopsis...
  81. ncbi Gene structures, classification and expression models of the AP2/EREBP transcription factor family in rice
    Akhter Most Sharoni
    Plant Genome Research Unit, Division of Genome and Biodiversity Research, National Institute of Agrobiological Sciences NIAS, Tsukuba, Ibaraki, 305 8602 Japan
    Plant Cell Physiol 52:344-60. 2011
    ..We further examined the stress responsiveness of most genes by reverse transcription-PCR. The study results should be useful in selecting candidate genes from specific subgroups for functional analysis...
  82. ncbi Dissection of a type VI secretion system in Edwardsiella tarda
    Jun Zheng
    Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore 117543
    Mol Microbiol 66:1192-206. 2007
    ..The interaction between EvpC and EvpP was demonstrated. Lastly, two proteins (EvpD and EvpJ) are not required for the T6SS-dependent secretion...
  83. ncbi A hybrid micro-macroevolutionary approach to gene tree reconstruction
    Dannie Durand
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    J Comput Biol 13:320-35. 2006
    ..It also offers a command line option that enables high-throughput analysis of a large number of trees...
  84. ncbi CAFE: a computational tool for the study of gene family evolution
    Tijl De Bie
    K U Leuven, OKP Research Group Tiensestraat 102, 3000 Leuven, Belgium
    Bioinformatics 22:1269-71. 2006
    ..AVAILABILITY: Software is available from http://www.bio.indiana.edu/~hahnlab/Software.html..
  85. pmc Genome sequence of Aedes aegypti, a major arbovirus vector
    Vishvanath Nene
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 316:1718-23. 2007
    ..An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species...
  86. ncbi Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids
    Linda Schaeffer
    GSF National Research Center for Environment and Health, Institute of Epidemiology, 85764 Neuherberg, Germany
    Hum Mol Genet 15:1745-56. 2006
    ..0 x 10(-13)). Carriers of the rare alleles of several SNPs and their respective haplotypes had a lower prevalence of allergic rhinitis and atopic eczema. No association was found for total and specific IgE levels...
  87. pmc Genome-wide identification and analysis of grape aldehyde dehydrogenase (ALDH) gene superfamily
    Yucheng Zhang
    College of Horticulture, Northwest A and F University, Key Laboratory of Horticultural Plant Biology and Germplasm Innovation in Northwest China, Ministry of Agriculture, Yangling, Shaanxi, People s Republic of China
    PLoS ONE 7:e32153. 2012
    ..Although ALDHs have been systematically investigated in several plant species including Arabidopsis and rice, our knowledge concerning the ALDH genes, their evolutionary relationship and expression patterns in grape has been limited...
  88. ncbi Allelic inactivation regulates olfactory receptor gene expression
    A Chess
    Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Cell 78:823-34. 1994
    ..This model, involving inactivation of one allelic array and cis control of the active array, provides a mechanism such that individual neurons express one or a small number of receptors...
  89. pmc Genome-wide classification and evolutionary analysis of the bHLH family of transcription factors in Arabidopsis, poplar, rice, moss, and algae
    Lorenzo Carretero-Paulet
    Department of Applied Biology, University of Almeria, 04120 Almeria, Spain
    Plant Physiol 153:1398-412. 2010
    ....
  90. ncbi Type III secretion: more systems than you think
    Paul Troisfontaines
    Biozentrum der Universitat Basel, CH 4056 Basel, Switzerland
    Physiology (Bethesda) 20:326-39. 2005
    ..There are probably a few hundred effectors interfering with control and signaling in eukaryotic cells and offering a wealth of new tools to cell biologists...
  91. ncbi A maximum likelihood method for detecting functional divergence at individual codon sites, with application to gene family evolution
    Joseph P Bielawski
    Department of Biology, University College London, London, WC1E 6BT, UK
    J Mol Evol 59:121-32. 2004
    ..Limitations of the new method are discussed...
  92. pmc Beyond aflatoxin: four distinct expression patterns and functional roles associated with Aspergillus flavus secondary metabolism gene clusters
    D Ryan Georgianna
    Department of Plant Pathology, Center for Integrated Fungal Research, North Carolina State University, Raleigh, NC 27695, USA
    Mol Plant Pathol 11:213-26. 2010
    ..Aflatoxin and CPA were found to have unique regulation, but are sufficiently similar that they would be expected to co-occur in substrates colonized with A. flavus...
  93. pmc Thirty-one flavors of Drosophila rab proteins
    Jun Zhang
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA
    Genetics 176:1307-22. 2007
    ..The high evolutionary conservation and low redundancy of Drosophila Rab proteins make these transgenic lines a useful tool kit for investigating Rab functions in vivo...
  94. pmc Phylogenomics reveals subfamilies of fungal nonribosomal peptide synthetases and their evolutionary relationships
    Kathryn E Bushley
    Department of Plant Pathology and Plant Microbe Biology, 334 Plant Science Bldg, Cornell University, Ithaca, NY, 14853, USA
    BMC Evol Biol 10:26. 2010
    ..We also characterized relationships of fungal NRPSs, a representative sampling of bacterial NRPSs, and related adenylating enzymes, including alpha-aminoadipate reductases (AARs) involved in lysine biosynthesis in fungi...
  95. ncbi Dietary n-3 and n-6 polyunsaturated fatty acid intake interacts with FADS1 genetic variation to affect total and HDL-cholesterol concentrations in the Doetinchem Cohort Study
    Yingchang Lu
    Division of Human Nutrition, Wageningen University Research Center, Wageningen, Netherlands
    Am J Clin Nutr 92:258-65. 2010
    ..Single nucleotide polymorphisms in the FADS gene cluster region have been associated with both PUFA concentrations in plasma or erythrocyte membrane phospholipids and cholesterol concentrations in recent genome-wide association studies...
  96. ncbi The evolution of animal chemosensory receptor gene repertoires: roles of chance and necessity
    Masatoshi Nei
    Institute of Molecular Evolutionary Genetics and Department of Biology, Pennsylvania State University, 328 Mueller Laboratory, University Park, Pennsylvania 16802, USA
    Nat Rev Genet 9:951-63. 2008
    ..It seems that mutation by gene duplication and inactivation has important roles in both the adaptive and non-adaptive evolution of chemosensation...
  97. pmc Analysis of achromobactin biosynthesis by Pseudomonas syringae pv. syringae B728a
    Andrew D Berti
    Department of Bacteriology, University of Wisconsin Madison, Madison, WI 53706, USA
    J Bacteriol 191:4594-604. 2009
    ..This work provides insights into the biosynthetic steps in the formation of achromobactin and is the first in vitro reconstitution of achromobactin biosynthesis...
  98. ncbi The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis
    Jeong Hoe Kim
    Department of Energy Plant Research Laboratory, Michigan State University, East Lansing, MI 48824 1312, USA
    Plant J 36:94-104. 2003
    ..These results indicate that AtGRF proteins play a role in the regulation of cell expansion in leaf and cotyledon tissues...
  99. pmc Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii
    Mark D Adams
    Department of Genetics, Case Western Reserve University School of Medicine, Cleveland, OH 44106 4955, USA
    J Bacteriol 190:8053-64. 2008
    ..These genes are enriched for transcription factors and transporters and suggest physiological features of A. baumannii that are related to adaptation for growth in association with humans...

Research Grants62

  1. Conditional HSF1 Expression for Ischemic Cardioprotection
    Ivor J Benjamin; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Different members of the HSP multigene family have been implicated the inhibition of ischemia- induced protein damage, abrogation of protein misfolding/aggregation, and prevention of mitochondrial ..
  2. NFATs and Vascular Injury
    Gadiparthi N Rao; Fiscal Year: 2013
    ..Nuclear factors of activated T cells (NFATs) are members of a multigene family of transcriptional factors that relate to Rel group and play an important role in the regulation of immune ..
  3. EVOLUTIONARY ORIGINS OF IMMUNE-TYPE GENES
    GARY WILLIAM LITMAN; Fiscal Year: 2013
    ..encoding Toll-like receptor (TLR) innate immune receptors as well as other immune gene families and 2) a multigene family encoding immunoglobulin variable domain-containing chitin-binding proteins (VCBPs) exhibits an extraordinary ..
  4. Keratins, Wound Reepithelialization, and Hair Follicle Cycling
    PIERRE COULOMBE; Fiscal Year: 2013
    ..They are encoded by an evolutionarily conserved multigene family, with 54 individual members subdivided into two major types (I and II)...
  5. P.falciparum var gene diversity and malaria control
    KAREN PATRICIA DAY; Fiscal Year: 2013
    ..falciparum where individuals in malaria endemic areas carry multiple distinct parasite genomes. The var multigene family encodes P...
  6. EVOLUTIONARY ORIGINS OF IMMUNE-TYPE GENES
    GARY LITMAN; Fiscal Year: 2009
    ..encoding Toll-like receptor (TLR) innate immune receptors as well as other immune gene families and 2) a multigene family encoding immunoglobulin variable domain-containing chitin-binding proteins (VCBPs) exhibits an extraordinary ..
  7. Structure-Function Studies of Tight Junction Membrane Proteins
    ALAN S YU; Fiscal Year: 2013
    ..a central role in these functions of the tight junction and hence are of high biological interest: claudin (a multigene family with 24 members), occludin, and tricellulin...
  8. Impact of seasonality and vector control on population structure of P.falciparum
    Mercedes Pascual; Fiscal Year: 2013
    ..ofthe blood stages known as erythrocyte membrane protein 1 (PfEMPI) encoded by up to 60 members ofthe var multigene family per haploid genome...
  9. Toward a High Resolution Structure of an Olfactory Receptor
    Steven L Youngentob; Fiscal Year: 2010
    ..Olfactory receptors comprise a large multigene family;in humans there are an estimated 400 functional genes found in many different chromosomal locations...
  10. The structural support role of keratins in skin
    PIERRE COULOMBE; Fiscal Year: 2013
    ..They are encoded by an evolutionarily conserved multigene family, with 54 individual members subdivided into two major types (I and II)...
  11. Tubulin Mutations in Neuronal Migration Disorders
    NICHOLAS COWAN; Fiscal Year: 2013
    Microtubules are assembled from a/B[unreadable] tubulin heterodimers. In mammals, a small multigene family encodes [unreadable]a- and [unreadable]B-tubulins, with each gene product (termed an isotype) having a distinct developmentally ..
  12. Hemin Receptor Gene Family of Bartonella quintana
    MICHAEL MINNICK; Fiscal Year: 2006
    ..In Specific Aim 2 we will analyze the expression patterns of the hbp multigene family over the course of infection in the human louse vector and a macaque primate model...
  13. Engineering histone genes to interrogate the epigenetic code in space and time
    Brian D Strahl; Fiscal Year: 2013
    ..We will use a transgenic strategy for replacement of the entire Drosophila histone multigene family with engineered gene clusters that express specific histone mutants, and create experimental tools for the ..
  14. STRUCTURE AND REGULATION OF THE CD1 MULTIGENE FAMILY
    PAUL BLEICHER; Fiscal Year: 1992
    ..The pattern of expression of this multigene family suggests prominent developmental and tissue specific regulatory elements...
  15. STRUCTURE/FUNCTION OF MYOSIN IN SKELETAL MUSCLE
    Gordon Lutz; Fiscal Year: 2001
    ..All vertebrates express a multigene family of the two myosin subunits; myosin heavy chain (MHC) and myosin light chain (MLC)...
  16. TYPE V COLLAGENASE IN RHEUMATOID ARTHRITIS
    Tayebeh Pourmotabbed; Fiscal Year: 2001
    ..Type V collagenase/gelatinase B is a member of this multigene family of enzymes which exhibits high specificity for denatured collagen, degrades native types V and XI collagen ..
  17. GENE EXPRESSION OF SALIVARY GLAND SPECIFIC GENES
    David Ann; Fiscal Year: 1993
    ..the structural characterization and physical linkage of the rat tissue-specific proline- rich protein multigene family and cloning at least one monkey proline-rich protein gene; and (iii) detecting and characterizing nuclear ..
  18. GENE EXPRESSION BY HUMAN GRANULOCYTIC EHRLICHIOSIS AG
    Yasuko Rikihisa; Fiscal Year: 2004
    ..They demonstrated that 44-kDa proteins (P44s) are encoded by a multigene family. Their recent study indicates that there are a total of approximately 18 copies of p44 genes and the HGE ..
  19. Synaptotagmin function in virus movement and plant development
    Sondra G Lazarowitz; Fiscal Year: 2010
    ..Synaptotagmins, a multigene family thought to be exclusive to animals, are calcium (Ca2+) sensors that regulate synaptic vesicle exo/endocytosis...
  20. HUMAN MULTIDRUG RESISTANCE--PGLYCOPROTEIN GENES
    IGOR RONINSON; Fiscal Year: 1992
    ..The mdrl gene is a member of a multigene family, which includes at least one other expressed gene, mdr2...
  21. VITAMIN D BINDING PROTEIN
    Nancy Cooke; Fiscal Year: 2003
    Vitamin D binding protein (DBP) is an abundant serum protein belonging to the multigene family that includes albumin, alpha- fetoprotein, and alpha-albumin/afamin. Multiple functions have been attributed to DBP...
  22. ANOXIA RESPONSIVE VL30 ELEMENTS
    Garth Anderson; Fiscal Year: 1992
    ..3. With VL30 representing a multigene family with 50-100 copies per cell in rat DNA, we will use restriction mapping of cDNA clones to determine if only ..
  23. MOLECULAR ASPECTS OF AMYLOIDOSIS
    WARREN LIAO; Fiscal Year: 1999
    DESCRIPTION: A mammalian multigene family, the serum amyloid A (SAA) gene family, is differentially regulated during inflammation...
  24. MODELS IN POPULATION GENETICS
    Glenys Thomson; Fiscal Year: 2000
    ..structure and function of the HLA genes, their disease associations, and the evolutionary features of this multigene family has benefitted from recent advances in molecular biology, immunology, disease modelling and population ..
  25. CLASS I MHC GENES EXPRESSED BY HUMAN TROPHOBLAST CELLS
    JOAN HUNT; Fiscal Year: 1999
    ..regulating expression, and to identify pregnancy-associated functions of antigens derived from this multigene family. Significant progress toward these long-range goals has been made in the current funding period, where ..
  26. ACTIONS OF INSECTICIDES ON SODIUM CHANNEL ISOFORMS
    DAVID SODERLUND; Fiscal Year: 2000
    ..that exhibit differential tissue distribution and developmental regulation and are encoded by members of a multigene family. Previous studies of pyrethroid action have not considered the differential sensitivity of sodium channel ..
  27. MAMMALIAN GENE STRUCTURE AND MAMMALIAN PHYLOGENY
    Wen Hsiung Li; Fiscal Year: 1990
    ..for the first three years are: (1) to understand the structure, function, and evolution of the apolipoprotein multigene family, (2) to resolve a long-standing controversy over the phylogenetic relationship among human, rat, rabbit, cow ..
  28. MOLECULAR STUDIES OF SODIUM CHANNELS IN SKELETAL MUSCLE
    Basil Darras; Fiscal Year: 1993
    ..Sodium channels exhibit different pharmacological and functional properties and are encoded by a multigene family. Three highly homologous sodium channel alpha subunits have been identified in rat brain by cDNA nucleotide ..
  29. MOLECULAR ANALYSIS OF ANTIGENIC VARIATION IN MALARIA
    Mary Galinski; Fiscal Year: 2000
    ..knowlesi (the SICA var genes), which are members of a large multigene family, it is now possible to study the mechanisms of antigenic variation in vivo as well as in-vitro...
  30. CONTROL OF MYOSIN TYPES IN INDIVIDUAL MUSCLE FIBERS
    Neal Rubinstein; Fiscal Year: 1993
    The isoforms of vertebrate sarcomeric myosin heavy chains (MHC) are encoded by the members of a multigene family. Adult skeletal muscles contain a heterogeneous population of fibers which can be characterized by these MHC isoforms...
  31. MOLECULAR ANALYSIS OF ANTIGENIC VARIATION IN MALARIA
    Mary Galinski; Fiscal Year: 2004
    ..They are encoded by the related SICAvar multigene family. This model system has been well characterized and enables the development and investigation of in-vivo ..
  32. GASTROINTESTINAL-LIVER ALKALINE PHOSPHATASES
    WING KAM; Fiscal Year: 1993
    Human alkaline phosphatase is an important multigene family with as many as five tissue-specific forms...
  33. MOLECULAR BASIS FOR SELECTIVITY & TRANSPORT IN ION PUMPS
    Rajini Rao; Fiscal Year: 1999
    ..in hand, we will focus on elucidating the molecular determinants of ion specificity and transport within this multigene family. Yeast was chosen as a model system because it is readily amenable to both biochemical and genetic approaches...
  34. GROWTH RELATED GENES IN VASCULAR SMOOTH MUSCLE
    MARK TAUBMAN; Fiscal Year: 2003
    ..SM-20 is a member of novel multigene family that encodes a 239 amino acid intracellular protein induced by platelet-derived growth factor in SMC culture...
  35. MOLECULAR CHARACTERIZATION OF THE A1 MULTIGENE FAMILY
    Wayne Yokoyama; Fiscal Year: 1993
    ..Our preliminary data demonstrate that the A1 multigene family maps to a contiguous stretch of mouse chromosome 6 to which another lymphoid cell surface antigen, NK1...
  36. ROLE OF H-2 IN ORAL-FACIAL DEVELOPMENT
    Tina Jaskoll; Fiscal Year: 1990
    The major histocompatability complex (MHC) of mammals (H-2 in mice; HLA in humans) is a multigene family whose members encode cell-surface glycoproteins...
  37. ANALYSIS OF 3 CARDIAC NA,K- TPASE A-SUBUNIT ISOFORMS
    Nelson Ruiz Opazo; Fiscal Year: 1991
    ..They are encoded by a multigene family that is differentially expressed in a tissue-specific and developmental manner...
  38. TUBULIN MUTATIONS AND PACLITAXEL RESISTANCE
    FERNANDO R CABRAL; Fiscal Year: 2010
    ..Mammalian cell tubulin is encoded by a multigene family that produces distinct gene products, or isotypes...
  39. INTRANUCLEAR REACTIONS IN DRUG RESISTANCE
    Kenneth Tew; Fiscal Year: 1993
    ..GST have evolved into a multigene family, with complex substrate specificities and regulation controls...
  40. OLFACTORY GLOMERULI--CELLULAR AND NETWORK MECHANISMS
    Michael Shipley; Fiscal Year: 2000
    ..Progress in the biophysics and molecular biology of olfactory transduction and the discovery of a large, multigene family of putative olfactory receptor genes (ORGs) have revolutionized our thinking about olfactory reception...
  41. DIFFERENTIATION OF ACTIN MYOGENESIS
    Robert Schwartz; Fiscal Year: 1991
    ..expression of the skeletal muscle Alpha actin structural gene from all other members within the actin multigene family, during muscle development in culture. Two dependent lines of investigation will be employed...
  42. Novel Innate Immune Receptor in Zebrafish
    GARY LITMAN; Fiscal Year: 2004
    ..We have cloned the novel immune-type receptor (NITR) genes, which constitute a large multigene family encoding transmembrane immunoglobulin (Ig)-type molecules...
  43. REGULATION OF THE PLASMA MEMBRANE CALCIUM ATPASE
    EMANUEL STREHLER; Fiscal Year: 2002
    ..Over twenty PMCA isoforms are generated from a multigene family and via alternative RNA splicing...
  44. Function of Mhc class lb molecules in vomeronasal organ
    Tomohiro Ishii; Fiscal Year: 2007
    ..We and others have reported that neurons of the basal layer express another multigene family, termed H2-Mv, representing nonclassical class I genes of the major histocompatibility complex (Mhc)...
  45. EPIDERMAL TRANS-ACTING FACTORS IN SKIN DEVELOPMENT
    Renata Polakowska; Fiscal Year: 1993
    ..Developmental regulation of genes includes a sequence of isoform transitions typified by the keratin multigene family, whose expression has distinct tissue-specific, temporal and spatial developmental patterns...
  46. IMMUNOLOGIC ANALYSIS--MULTIDRUG RESISTANT GENE FAMILY
    James Croop; Fiscal Year: 1992
    ..This gene which is a member of a multigene family has been shown to convey resistance to multiple drugs in vitro...
  47. GENOMIC ORGANIZATION OF ZEIN GENE SUBFAMILIES
    IRWIN RUBENSTEIN; Fiscal Year: 1991
    ..storage protein in maize endosperm tissue protein bodies, involves the coordinated activity of a complex multigene family of some 100 genes...
  48. MARKERS OF EPIDERMAL DIFFERENTIATION
    Tung Tien Sun; Fiscal Year: 1991
    ..These keratins belong to a multigene family. They can be divided into an acidic (also known as Type I) and a basic (Type II) subfamily, and it has been ..
  49. CHARACTERIZATION AND EXPRESSION OF AN LG VH GENE FAMILY
    DAN SCHULZE; Fiscal Year: 1991
    ..The V/H 7183 gene family was chosen for study for several reasons. This multigene family has been mapped to be the most proximal to the D-J/H sequences and appears to be preferentially rearranged in ..
  50. EVOLUTIONARY GENETICS OF R LOCI IN ARABIDOPSIS
    Joy Bergelson; Fiscal Year: 2007
    Plant defense against pathogens is induced by R-genes, a large multigene family of signal transducing proteins...
  51. ASSOCIATION OF H-2 AND LUNG DEVELOPMENT
    Tina Jaskoll; Fiscal Year: 1990
    The major histocompatibility complex (MHC) of mammals (H-2 in mice; HLA in humans) is a multigene family whose members encode cell - surface glycoproteins. Recently, attention has been...
  52. CHARACTERIZATION OF THE LY6 MULTIGENE FAMILY
    Alfred Bothwell; Fiscal Year: 2004
    ..We have observed that Ly-6I together with Ly-6AIE, Ly-6C or Ly-6G may define distinct cell populations and we will determine whether Ly-6I can be used to further define hematopoietic stem cells. ..
  53. MOLECULAR CHARACTERIZATION OF CARDIAC NA+ CHANNELS
    RICHARD ROGART; Fiscal Year: 1993
    Mammalian voltage-gated Na+ channels are encoded by a multigene family. The relationship of cardiac Na+ channel(s) to this family is currently unknown. "TTX- resistant" cardiac NA+ channels in other excitable tissue...
  54. FUNCTION OF SGS1, A HOMOLOG OF BLM AND WRN
    Rodney Rothstein; Fiscal Year: 2000
    ..Thus, the study of Sgs1 in yeast may provide insights into the function of the members of this multigene family and may yield important clues to the etiology of cancer in these two syndromes...
  55. MOLECULAR MECHANISMS OF ODOR MAPPING
    CHARLES GREER; Fiscal Year: 2002
    ..The turning point in this revolution was the seminal discovery, now seven years ago, of a large multigene family in mammals that encodes odor receptors...
  56. GENE ORGANIZATION AND EXPRESSION OF TRNA
    WALTER HOLMES; Fiscal Year: 1991
    ..term goal is to gain an overall understanding of the evolution, gene organization, and regulation of the tRNA multigene family in Escherichia coli...
  57. Re-engineering the MEGA software package
    Sudhir Kumar; Fiscal Year: 2009
    ..These core software enhancements will contribute to the longevity of MEGA for use in molecular evolution, bioinformatics, functional genomics, computational biology, and basic biomedicine applications. ..
  58. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..dissemination of ingested BaP and will be informative in clinical studies in which we would determine which haplotypes of these three human genes might be associated with resistance vs. sensitivity to PAH-induced toxicity and cancer. ..
  59. Molecular Genetics of Cadmium Toxicity
    Daniel W Nebert; Fiscal Year: 2010
    ....
  60. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
    ..abstract_text> ..
  61. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
    ..S. population. ..