mdr genes

Summary

Summary: Genes responsible for multidrug resistance resulting from their overexpression in mammalian cells. Mammalian P-glycoproteins are encoded by small MDR gene families. The human multidrug resistance 1 (MDR1) gene responds to environmental stress including various anticancer agents. It is a major determinant in the development of resistance to a large number of cancer chemotherapeutic agents. (Biochem Biophys Res Commun 1994;199(3):1428-35; Cancer Res 1994:54(6):1536-41)

Top Publications

  1. ncbi Drug resistance induced by ouabain via the stimulation of MDR1 gene expression in human carcinomatous pulmonary cells
    F Brouillard
    , , Paris, France
    Cancer Res 61:1693-8. 2001
  2. ncbi [The effect of tetrandrine on the expression of the P170, LRP and TOPO II in S180's tumor cell induced by chemotherapy in the mice with acquired multi-drug resistance]
    Gui Hai Li
    ShanDong Academy of Chinese Medicine, Jinan 250014, China
    Zhongguo Zhong Yao Za Zhi 30:1280-2. 2005
  3. ncbi Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance
    Catia Marzolini
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Clin Pharmacol Ther 75:13-33. 2004
  4. ncbi Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
    Ric N Price
    Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, London, UK
    Lancet 364:438-47. 2004
  5. ncbi Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study
    Jacques Fellay
    Division of Infectious Diseases, University Hospital of Lausanne, Lausanne, Switzerland
    Lancet 359:30-6. 2002
  6. pmc Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
    T C White
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, and Seattle Biomedical Research Institute, 98109, USA
    Antimicrob Agents Chemother 41:1482-7. 1997
  7. ncbi Pharmacogenomics of ABC transporters and its role in cancer chemotherapy
    Alex Sparreboom
    Clinical Pharmacology Research Core, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Drug Resist Updat 6:71-84. 2003
  8. ncbi MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study
    David W Haas
    Division of Infectious Diseases, Vanderbilt University School of Medicine, 345 24th Avenue, North, Suite 105, Nashville, TN 37212, USA
    J Acquir Immune Defic Syndr 34:295-8. 2003
  9. ncbi Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response
    Zabrina L Brumme
    B C Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, Canada
    AIDS 17:201-8. 2003
  10. ncbi P-glycoprotein plays a drug-efflux-independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway
    M Pallis
    Division of Haematology, School of Clinical and Laboratory Sciences, University of Nottingham, and the Nottingham City Hospital, Nottingham, UK
    Blood 95:2897-904. 2000

Detail Information

Publications226 found, 100 shown here

  1. ncbi Drug resistance induced by ouabain via the stimulation of MDR1 gene expression in human carcinomatous pulmonary cells
    F Brouillard
    , , Paris, France
    Cancer Res 61:1693-8. 2001
    ..Thus, although ouabain acts extracellularly, it may stimulate MDR-1 gene expression and P-gp synthesis and make cells resistant to hydrophobic cytotoxic compounds...
  2. ncbi [The effect of tetrandrine on the expression of the P170, LRP and TOPO II in S180's tumor cell induced by chemotherapy in the mice with acquired multi-drug resistance]
    Gui Hai Li
    ShanDong Academy of Chinese Medicine, Jinan 250014, China
    Zhongguo Zhong Yao Za Zhi 30:1280-2. 2005
    ..To observe the effect of tetrandrine on the P170 production expressed by multi-drug resistance gene, lung resistant protein (LRP), and topoisomeras II and elucidate the underlying molecular mechanism...
  3. ncbi Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance
    Catia Marzolini
    Division of Clinical Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Clin Pharmacol Ther 75:13-33. 2004
    ..In addition, issues relating to MDR1 haplotypes, environmental factors, and study design, as potential confounding factors of the observed MDR1 polymorphism effect in vivo, are also discussed...
  4. ncbi Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
    Ric N Price
    Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, London, UK
    Lancet 364:438-47. 2004
    ..A combination of artesunate with mefloquine now cures more than 95% of acute infections. For both treatment regimens, the underlying mechanisms of resistance are not known...
  5. ncbi Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study
    Jacques Fellay
    Division of Infectious Diseases, University Hospital of Lausanne, Lausanne, Switzerland
    Lancet 359:30-6. 2002
    ..This variability could have a genetic basis. We did a pharmacogenetics study to analyse the association between response to antiretroviral treatment and allelic variants of several genes...
  6. pmc Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus
    T C White
    Department of Pathobiology, School of Public Health and Community Medicine, University of Washington, and Seattle Biomedical Research Institute, 98109, USA
    Antimicrob Agents Chemother 41:1482-7. 1997
    ..A compilation of the genetic alterations identified in this series suggests that resistance develops gradually and is the sum of several different changes, all of which contribute to the final resistant phenotype...
  7. ncbi Pharmacogenomics of ABC transporters and its role in cancer chemotherapy
    Alex Sparreboom
    Clinical Pharmacology Research Core, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Drug Resist Updat 6:71-84. 2003
    ..This review focuses on recent advances in the pharmacogenomics of ABC transporters, and discusses potential implications of genetic variants for the chemotherapeutic treatment of cancer...
  8. ncbi MDR1 gene polymorphisms and phase 1 viral decay during HIV-1 infection: an adult AIDS Clinical Trials Group study
    David W Haas
    Division of Infectious Diseases, Vanderbilt University School of Medicine, 345 24th Avenue, North, Suite 105, Nashville, TN 37212, USA
    J Acquir Immune Defic Syndr 34:295-8. 2003
    ..It is concluded with 95% confidence that phase 1 viral decay differences between exon 26 TT and CC groups are unlikely to exceed 18%...
  9. ncbi Influence of polymorphisms within the CX3CR1 and MDR-1 genes on initial antiretroviral therapy response
    Zabrina L Brumme
    B C Centre for Excellence in HIV AIDS, St Paul s Hospital, Vancouver, Canada
    AIDS 17:201-8. 2003
    ....
  10. ncbi P-glycoprotein plays a drug-efflux-independent role in augmenting cell survival in acute myeloblastic leukemia and is associated with modulation of a sphingomyelin-ceramide apoptotic pathway
    M Pallis
    Division of Haematology, School of Clinical and Laboratory Sciences, University of Nottingham, and the Nottingham City Hospital, Nottingham, UK
    Blood 95:2897-904. 2000
    ..The pgp reversal agent PSC-833 acts, at least in part, by a pgp independent mechanism to alter SM distribution and to augment apoptosis induced in AML cells by serum and growth factor withdrawal. (Blood. 2000;95:2897-2904)..
  11. ncbi Reversal of multidrug resistance: lessons from clinical oncology
    Susan F Bates
    Molecular Therapeutics Section, Medicine Branch, National Cancer Institute, Bethesda, MD 20892, USA
    Novartis Found Symp 243:83-96; discussion 96-102, 180-5. 2002
    ..Using third generation Pgp antagonists and properly designed clinical trials, it should be possible to determine the contribution of modulators to the reversal of clinical drug resistance...
  12. ncbi The genetic basis of fluconazole resistance development in Candida albicans
    Joachim Morschhäuser
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, Wurzburg, Germany
    Biochim Biophys Acta 1587:240-8. 2002
    ..Disruption of both alleles of the MDR1 gene in resistant C. albicans isolates abolishes their resistance to these drugs, providing genetic evidence that MDR1 mediates multidrug resistance in C. albicans...
  13. ncbi Identification of promoter elements responsible for the regulation of MDR1 from Candida albicans, a major facilitator transporter involved in azole resistance
    Benedicte Rognon
    Institute of Microbiology, University Hospital Lausanne, Rue du Bugnon 48, CH 1011 Lausanne, Switzerland
    Microbiology 152:3701-22. 2006
    ....
  14. ncbi Molecular markers for drug resistance in malaria: use in treatment, diagnosis and epidemiology
    Walther Helmut Wernsdorfer
    Department of Specific Prophylaxis and Tropical Medicine, Institute of Pathophysiology, University of Vienna, Austria
    Curr Opin Infect Dis 16:553-8. 2003
    ..The identification and implications of molecular markers for antimalarial drug resistance - the subject of this review - are key issues in elucidating and eventually controlling resistance...
  15. pmc Transcriptional regulation of MDR1, encoding a drug efflux determinant, in fluconazole-resistant Candida albicans strains through an Mcm1p binding site
    Perry J Riggle
    Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA
    Eukaryot Cell 5:1957-68. 2006
    ..Thus, the general transcription factor Mcm1p participates in the regulation of MDR1 expression...
  16. ncbi Quantification of the expression of multidrug resistance-related genes in human tumour cell lines grown with free doxorubicin or doxorubicin encapsulated in polyisohexylcyanoacrylate nanospheres
    Armelle Laurand
    Laboratoire de Pharmacologie des Agents Anticancéreux, Universite Victor Segalen Bordeaux 2, and Institut Bergonié, 229 Cours de l Argonne, 33076 Bordeaux, France
    Anticancer Res 24:3781-8. 2004
    ..Our results show that several mechanisms may be involved in the acquisition of drug resistance and that drug encapsulation markedly alters or delays these processes...
  17. ncbi MDR1 and MRP1 gene expression are independent predictors for treatment outcome in adult acute myeloid leukaemia
    Markus Schaich
    Medizinische Klinik und Poliklinik I, Universitätsklinikum C G Carus, Dresden, Germany
    Br J Haematol 128:324-32. 2005
    ..Our study shows that resistance gene expression should be considered together with age, cytogenetics and FLT3 mutational status for risk-adapted treatment strategies in AML in the future...
  18. ncbi Sequence diversity and haplotype structure in the human ABCB1 (MDR1, multidrug resistance transporter) gene
    Deanna L Kroetz
    Department of Biopharmaceutical Sciences, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0446, USA
    Pharmacogenetics 13:481-94. 2003
    ....
  19. pmc MDR1-mediated drug resistance in Candida dubliniensis
    S Wirsching
    , , , Germany
    Antimicrob Agents Chemother 45:3416-21. 2001
    ..albicans and C. dubliniensis strains seems to confer the same drug resistance profile in both species...
  20. ncbi MDR1 C3435T genetic polymorphism does not influence the response to antiretroviral therapy in drug-naive HIV-positive patients
    Milena Nasi
    Department of Biomedical Sciences, University of Modena and Reggio Emilia School of Medicine, Via Campi 287, 41100 Modena, Italy
    AIDS 17:1696-8. 2003
    ..The MDR1 C3435Tpolymorphism did not influence response to therapy, suggesting no disadvantages for individuals with a different genotype...
  21. pmc Overexpression of the MDR1 gene is sufficient to confer increased resistance to toxic compounds in Candida albicans
    Davina Hiller
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, D 97070 Wurzburg, Germany, and Institute of Microbiology, University Hospital Lausanne, Switzerland
    Antimicrob Agents Chemother 50:1365-71. 2006
    ..These results demonstrate that MDR1 overexpression in C. albicans is sufficient to confer resistance to some toxic compounds that are substrates of this efflux pump but that the degree of resistance depends on the Mdr1p expression level...
  22. ncbi Multiple drug resistance protein (MDR-1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) gene expression in childhood acute lymphoblastic leukemia
    Elvis Terci Valera
    Laboratory of Pediatric Oncology, Department of Pediatrics, University Hospital, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Sao Paulo Med J 122:166-71. 2004
    ..Expression of genes for the multiple drug resistance protein (MDR-1), multidrug resistance-related protein (MRP), and lung resistance protein (LRP) may confer the phenotype of resistance to the treatment of neoplasias...
  23. pmc Multiple cis-acting sequences mediate upregulation of the MDR1 efflux pump in a fluconazole-resistant clinical Candida albicans isolate
    Davina Hiller
    Institut für Molekulare Infektionsbiologie, Universitat Wurzburg, Rontgenring 11, D 97070 Wurzburg, Germany
    Antimicrob Agents Chemother 50:2300-8. 2006
    ..albicans and that the mutation(s) that causes constitutive MDR1 overexpression and drug resistance in clinical C. albicans isolates affects the activities of several of these transcription factors...
  24. ncbi MDR1 genetic polymorphism does not modify either cell permissiveness to HIV-1 or disease progression before treatment
    Gabriela Bleiber
    Institute of Microbiology and Division of Infectious Diseases, University Hospital of Lausanne, Lausanne, Switzerland
    J Infect Dis 189:583-6. 2004
    ....
  25. ncbi Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids
    Noelia Duarte
    CECF, Faculty of Pharmacy, University of Lisbon, Av das Forcas Armadas, 1600 083 Lisbon, Portugal
    Bioorg Med Chem 15:546-54. 2007
    ..Latilagascenes D-F (1-3) are new compounds whose structures were established on the basis of spectroscopic methods, including 2D NMR experiments (COSY, HMQC, HMBC and NOESY)...
  26. ncbi [Reversal effect of berbamine on multidrug resistance of K562/A02 cells and its mechanism]
    Yan Qiu Han
    Department of Hematology The First Hospital, Peking University, Beijing 100034, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 11:604-8. 2003
    ..In conclusion, BBM could increase intracellular concentration of ADR in K562/A02 that down-regulated expression level of mdr1 mRNA and P-gp and survivin so that the sensitivity of K562/A02 to ADR was increased significantly...
  27. ncbi Reversing antibiotic resistance
    Rebecca Hodgkinson
    Expert Opin Investig Drugs 11:1023-32. 2002
    ..There is a continuing search, not only for new chemotherapeutic agents, but also for agents that can reverse the acquired resistance to existing agents...
  28. ncbi [Detection of P-glycoprotein and glutathine S-transferase in mucoepidermoid carcinoma of salivary gland]
    Jia He
    Key Lab of Oral Biomedical Engineering Ministry of Education, Sichuan University, Chengdu 610041, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 22:115-6, 151. 2004
    ..The aim of this study was to investigate the mechanism(MDR) of multidrug resistance(MDR) of mucoepidermoid carcinoma in salivary gland...
  29. ncbi [Reversal of multidrug resistance of tumor cells by anti-mdr1 ribozyme]
    Peng Gao
    Department of Pathology, School of Medicine, University of Shandong, Jinan 250012, China
    Zhonghua Bing Li Xue Za Zhi 33:251-4. 2004
    ..To stably reverse the multidrug resistance (MDR) of breast carcinoma cells in vitro...
  30. ncbi Multidrug resistance in gastric cancer: recent research advances and ongoing therapeutic challenges
    Dexin Zhang
    Institute of Digestive Disease and State Key Laboratory of Cancer Biology, Xjing Hospital, The Fourth Military Medical University, 15 West Chang Le Road, Xi an, Shaanxi 710032, PR China
    Expert Rev Anticancer Ther 7:1369-78. 2007
    ..The new findings may provide new clues to the mechanisms of MDR and enable the selection of new candidates for targeting MDR in human gastric cancer...
  31. ncbi Evaluation of MS-209, a novel multidrug-resistance-reversing agent, in tumour-bearing mice by technetium-99m-MIBI imaging
    Mitsuaki Tatsumi
    Division of Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Japan
    Eur J Nucl Med Mol Imaging 29:288-94. 2002
    ..99mTc-MIBI imaging with MS-209 prior to chemotherapy should contribute significantly to the treatment strategy in patients with multidrug-resistant tumours...
  32. ncbi Functional polymorphisms of the human multidrug resistance (MDR1) gene: correlation with P glycoprotein expression and activity in vivo
    Ulrich Brinkmann
    Epidauros Biotechnology, Pharmacogenetics Laboratory, Bernried, Germany
    Novartis Found Symp 243:207-10; discussion 210-2, 231-5. 2002
    ....
  33. ncbi MDR1 modulators improve the chemotherapy response of human hepatoblastoma to doxorubicin in vitro
    Steven Warmann
    Department of Pediatric Surgery, University of Tubingen, Germany
    J Pediatr Surg 37:1579-84. 2002
    ..This study investigates the effects of 3 chemosensitizers (the cyclosporin analogue SDZ PSC 833 (PSC 833), the acridone carboxamide derivative GG 918, and verapamil) on the chemotherapy of HB in vitro...
  34. ncbi Correlation between cyclin A gene expression in adult patients with acute leukemia and drug resistance
    Jie Ma
    Department of Hematology, Second Hospital, Hebei Medical University, Shijiazhuang 050000
    J Huazhong Univ Sci Technolog Med Sci 23:245-8. 2003
    ..It was concluded that lower expression of cyclin A gene might be an unfavorable prognostic factor for patients with AL, and detection of both cyclin A and Top II alpha gene expression would predict drug resistance in AL patients...
  35. ncbi [To set up a mdrl multidrug resistant model of orthotopic transplantation of liver carcinoma in nude mice]
    Yu Han
    Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Zhonghua Wai Ke Za Zhi 41:676-8. 2003
    ..To set up a mdr1 multidrug resistant model of orthotopic transplantation of liver carcinoma in nude mice by intermittent abdominal chemotherapy...
  36. ncbi Modulation of multidrug resistance gene expression in human breast cancer cells by (-)-gossypol-enriched cottonseed oil
    Weiping Ye
    Laboratory of Reproductive and Molecular Endocrinology, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210 1092, USA
    Anticancer Res 27:107-16. 2007
    ....
  37. ncbi Correlation between GP-170 expression, prognosis, and chemoresistance of superficial bladder carcinoma
    Vincenzo Serretta
    Section of Urology, Department of Internal Medicine, Cardiovascular and Nephro Urological Diseases, University of Palermo, Via Malaspina 136, 90145, Palermo, Italy
    J Cancer Res Clin Oncol 129:472-6. 2003
    ..To study GP-170 in superficial bladder cancer at initial diagnosis and at recurrence and to evaluate if intravesical chemoprophylaxis modifies the expression of GP-170 in tumor recurrences...
  38. ncbi ClC-3 expression enhances etoposide resistance by increasing acidification of the late endocytic compartment
    Karsten H Weylandt
    Medical Research Council Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom
    Mol Cancer Ther 6:979-86. 2007
    ..This study therefore provides first evidence for a role of intracellular CLC proteins in the modulation of cancer drug resistance...
  39. ncbi [Drug resistance mediated by ABC transporters]
    Megumi Yoshikawa
    Dept of Drug Metabolism and Disposition, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose shi, Tokyo 204 8588, Japan
    Gan To Kagaku Ryoho 31:1-6. 2004
    ..Functional analysis of the genetic polymorphism of ABC transporters would greatly contribute to our understanding of individual differences in the drug response and also to the development of personalized medicine in the near future...
  40. ncbi The basic and clinical implications of ABC transporters, Y-box-binding protein-1 (YB-1) and angiogenesis-related factors in human malignancies
    Michihiko Kuwano
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582
    Cancer Sci 94:9-14. 2003
    ..Angiogenesis is also involved in tumor growth, invasion and metastasis of various malignancies, and so angiogenesis-related molecules also offer novel molecular targets for anticancer therapeutics...
  41. ncbi [Induction of multidrug resistance in Tca8113 cells by transient exposure to different chemotherapeutic drugs]
    Ping Zhang
    Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China
    Hua Xi Kou Qiang Yi Xue Za Zhi 21:70-3. 2003
    ..The purpose of this study was to determine the effect of transient exposure to chemotherapeutic drugs on multidrug resistance of Tca8113 cells...
  42. ncbi Small interfering RNA-induced suppression of MDR1 (P-glycoprotein) restores sensitivity to multidrug-resistant cancer cells
    Hao Wu
    Department of Pharmacology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08901, USA
    Cancer Res 63:1515-9. 2003
    ..These studies indicate that RNA interference can modulate MDR in preclinical models...
  43. ncbi Phosphorylation of RNA helicase A by DNA-dependent protein kinase is indispensable for expression of the MDR1 gene product P-glycoprotein in multidrug-resistant human leukemia cells
    Xiaoling Zhong
    Department of Pharmacology and Toxicology and Indiana University Cancer Center, 1044 West Walnut Street, Indianapolis, Indiana 46202, USA
    Biochemistry 46:5766-75. 2007
    ..The indispensable role played by DNA-PK in P-gp overexpression in MDR leukemia cells in this report identifies targeted DNA-PK inhibition as a rational strategy to reverse drug resistance in cancer...
  44. ncbi Induction of autoantibodies to murine P-glycoprotein: consequences on drug sensitivity in MDR cancer cells and on the expression of mdr genes in organs
    Laura Perrin
    Laboratory of Biochemistry, EA 3796, IFR 53 Biomolecules, 51 Rue Cognac Jay, 51096 Reims Cedex, France
    Biochem Biophys Res Commun 358:325-30. 2007
    ..These results suggest that the induction of autoantibodies to P-gp is a safe strategy to overcome MDR in cancer chemotherapy...
  45. ncbi In vitro chemoresistance profile and expression/function of MDR associated proteins in resistant cell lines derived from CCRF-CEM, K562, A549 and MDA MB 231 parental cells
    V Noskova
    Laboratory of Experimental Medicine, Dpt of Pediatrics, Faculty of Medicine, Palacky University and Faculty Hospital in Olomouc, Olomouc, Czech Republic
    Neoplasma 49:418-25. 2002
    ....
  46. ncbi Gene expression of CYP3A4, ABC-transporters (MDR1 and MRP1-MRP5) and hPXR in three different human colon carcinoma cell lines
    Arabelle Pfrunder
    Department of Clinical Pharmacology and Toxicology, University Hospital of Basel, Basel, Switzerland
    J Pharm Pharmacol 55:59-66. 2003
    ..We concluded that LS180 cells were a suitable model to study MDR1 and CYP3A4 induction, but for drug transport studies Caco-2 parental and TC-7 cells would be preferred as the more physiological model...
  47. ncbi Association of genomic imbalances with drug resistance and thermoresistance in human gastric carcinoma cells
    Holger Tonnies
    Institute of Human Genetics, Humboldt University Berlin, Charite Campus Virchow Klinikum, Berlin, Germany
    Int J Cancer 103:752-8. 2003
    ..The importance of these cell variant-specific genomic imbalances in the development of MDR and thermoresistance is discussed and remains to be elucidated...
  48. ncbi Impact of the expression of P glycoprotein, the multidrug resistance-related protein, bcl-2, mutant p53, and heat shock protein 27 on response to induction therapy and long-term survival in patients with de novo acute myeloid leukemia
    Sabine Kasimir-Bauer
    Departments of Internal Medicine Cancer Research, University of Essen, Medical School, West German Cancer Center, Essen, Germany
    Exp Hematol 30:1302-8. 2002
    ..Resistance to chemotherapy-induced apoptosis and a multidrug-resistance phenotype is the major problem in the treatment of acute myeloid leukemia (AML)...
  49. ncbi [Effects of schisandrin B on reversing multidrug resistance in human breast cancer cells transfected with mdr1 gene]
    Ling Li
    Cancer Institute, Second Affiliated Hospital of Zhejiang University, Hangzhou 310009, China
    Zhonghua Yi Xue Za Zhi 85:1633-7. 2005
    ..To investigate the multidrug resistance (MDR) reversal activity of schisandrin B (SchB) in transfected human breast cancer cell line MCF-7/MDR1...
  50. ncbi Induction of multidrug resistance in MOLT-4 cells by anticancer agents is closely related to increased expression of functional P-glycoprotein and MDR1 mRNA
    Zhen Li Liu
    Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    Cancer Chemother Pharmacol 49:391-7. 2002
    ..The aim of this study was to investigate the multidrug resistance (MDR) pattern, MDR gene and P-glycoprotein (P-gp) expression, and P-gp function in drug-induced human T-lymphoblastoid leukemia MOLT-4 sublines...
  51. ncbi ABC transporters and the accumulation of imatinib and its active metabolite CGP74588 in rat C6 glioma cells
    Xavier Declèves
    Universite Paris Descartes, Faculte de Pharmacie, Neuropsychopharmacologie des Addictions, CNRS, UMR7157 et Université Paris 7, Paris F 75010, France
    Pharmacol Res 57:214-22. 2008
    ..5-fold. Thus CGP74588 is readily transported by the Pgp in rat C6 gliomas cells, which raises the question of the role of Pgp in the resistance of recurrent glioblastomas to imatinib...
  52. ncbi Role of chemotherapy resistance genes in outcome of neuroblastoma
    Patricia De Cremoux
    Department of Tumor Biology, Institut Curie, 26 Rue d Ulm, Paris Cedex, France
    Pediatr Blood Cancer 48:311-7. 2007
    ..Most patients with localized disease usually have a favorable prognosis, but patients with advanced disease have a poor prognosis despite combination chemotherapy. Treatment failure may be attributable to resistance to cytotoxic drugs...
  53. ncbi Improving P-gp expression in human mononuclear cells in vitro transfected by multidrug resistance-1 mRNA
    Yang Xiang
    Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730
    Chin Med Sci J 20:48-50. 2005
    ..To evaluate the expression and function activity of P-glycoprotein (P-gp) in human mononuclear cells (MNCs) in vitro transfected by multidrug resistance-1 (MDR1) mRNA...
  54. ncbi Stable suppression of MDR-1 gene using siRNA expression vector to reverse drug resistance in a human uterine sarcoma cell line
    Jun Hua
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, Box 8064, 4911 Barnes Hospital Plaza, St Louis, MO 63110, USA
    Gynecol Oncol 98:31-8. 2005
    ..The impact of transfecting the RNAi upon MDR-1 mRNA and P-glycoprotein expression as well as resultant chemotherapy resistance was assessed...
  55. ncbi CIAPIN1 confers multidrug resistance by upregulating the expression of MDR-1 and MRP-1 in gastric cancer cells
    Zhiming Hao
    State Key Laboratory of Cancer Biology, Institute of Digestive Diseases, Xijing Hospital, The Fourth Military Medical University, Xi an, Shaanxi Province, China
    Cancer Biol Ther 5:261-6. 2006
    ..In addition, Western blotting revealed that CIAPIN1 decreased the expression of Bcl-2, Bax and p53. Therefore, it is concluded that CIAPIN1 confers MDR in gastric cancer cells, likely by upregulating MDR-1 and MRP-1...
  56. ncbi Reversal of MDR1 gene-dependent multidrug resistance using short hairpin RNA expression vectors
    Hui zhu Gan
    Central Research Department, China Japan Union Hospital, Jilin University, Changchun 130031, China
    Chin Med J (Engl) 118:893-902. 2005
    ..In this study, we reversed MDR using shRNA expression vectors in a multidrug-resistant human breast cancer cell line (MCF-7/AdrR)...
  57. ncbi Effects of P-glycoprotein modulation on the chemotherapy of xenotransplanted human hepatoblastoma
    Steven W Warmann
    Department of Pediatric Surgery, University of Tubingen, Tubingen, Germany
    Pediatr Hematol Oncol 22:373-86. 2005
    ..They do not induce a further increase of drug resistance in the tumors. The data provide evidence that chemosensitizers might improve treatment results in patients with advanced or relapsed HB...
  58. ncbi Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs
    Emma K Baker
    Epigenetics in Human Health and Disease Laboratory, The Alfred Medical Research and Education Precinct, Baker Medical Research Institute, Commercial Road, Prahran, Victoria 3181, Australia
    Oncogene 24:8061-75. 2005
    ..Our results demonstrate that chemotherapeutic drugs can actively induce epigenetic changes within the MDR1 promoter, and enhance the MDR phenotype...
  59. ncbi [Nitric oxide synthase expression and multiple drug resistance in patients with acute leukemia]
    Yan Zhu
    Department of Hematology, Xiangya Hospital, Central South University, Changsha 41008, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 29:25-7. 2004
    ..To determine the relationship between nitric oxide synthase (NOS) expression and Pgp/mdr-1...
  60. pmc Heat shock-independent induction of multidrug resistance by heat shock factor 1
    Thierry Tchenio
    Unité de Génétique Moléculaire et Intégrations des Fonctions Cellulaires, CNRS UPR1983, 7 rue Guy Moquet, BP8, 94801 Villejuif Cedex, France
    Mol Cell Biol 26:580-91. 2006
    ..We further provide evidence that the induction of MDR-1 expression occurs at a posttranscriptional level, revealing a novel undocumented role for hypophosphorylated HSF1 in posttranscriptional gene regulation...
  61. ncbi Reversal of MDR1/P-glycoprotein-mediated multidrug resistance by vector-based RNA interference in vitro and in vivo
    Zhi Shi
    State Key Laboratory for Oncology in South China, Cancer Center, Sun Yat senUniversity, Guangzhou, China
    Cancer Biol Ther 5:39-47. 2006
    ..0%, but the same dose of vincristine didn't inhibit the growth of KBv200 solid tumors significantly. These results suggest that administration of RNAi targeted MDR1 gene can effectively reverse MDR both in vitro and in vivo models...
  62. ncbi Preliminary studies on phenothiazine-mediated reversal of multidrug resistance in mouse lymphoma and COLO 320 cells
    Beata Pajak
    Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, ul Nowoursynowska 159, 02 776 Warsaw, Poland
    In Vivo 19:1101-4. 2005
    ..The results of this study provide information about a new group of compounds that offer promise in multidrug resistance reversal in tumor cells...
  63. ncbi [Effects of Ras antisense oligoribonucleotide on multidrug resistance of pancreatic carcinoma Pc-2 cells]
    Xi Chen
    Department of General Surgery, The Second Affiliated Hospital, Xi an Jiaotong University, Xi an 710004, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 27:633-6. 2005
    ..To investigate the role of Ras antisense oligoribonucleotide (ASODN) in multidrug resistance (MDR) of pancreatic carcinoma Pc-2 cells...
  64. ncbi Induction of resistance to Aplidin in a human ovarian cancer cell line related to MDR expression
    Gianluca Tognon
    Department of Oncology, Flow Cytometry Unit, Mario Negri Institute, Milan, Italy
    Cancer Biol Ther 4:1325-30. 2005
    ..The finding that cells over-expressing Pgp are resistant to Aplidin was confirmed in CEM/VLB 100 cells, that was found to be 5-fold resistant to Aplidin compared to the CEM parental cell line...
  65. ncbi Dual agent chemoprotection by retroviral co-expression of either MDR1 or MRP1 with the P140K mutant of O6-methylguanine-DNA-methyl transferase
    Thomas D Southgate
    Cancer Research UK Gene Therapy Group, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Wilmslow Road, Manchester M20 4BX, UK
    J Gene Med 8:972-9. 2006
    ..This combination of drug transporter and DNA repair function may provide an effective in vivo protection of the haematopoietic compartment during tumour ablation using combination chemotherapy...
  66. pmc Isolation and characterization of an IGROV-1 human ovarian cancer cell line made resistant to Ecteinascidin-743 (ET-743)
    E Erba
    Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
    Br J Cancer 82:1732-9. 2000
    ....
  67. ncbi Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells
    Ulrike Stein
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Int J Cancer 97:751-60. 2002
    ..Within the thermoresistant variants, however, the increase in ABC transporter expression did obviously not influence the MDR phenotype...
  68. ncbi Improvement of combination chemotherapy tolerance by introduction of polycistronic retroviral vector drug resistance genes MGMT and MDR1 into human umbilical cord blood CD34+ cells
    Jishi Wang
    Jiangsu Institute of Hematology, First Affiliated Hospital of Suzhou University, Suzhou 215006, People s Republic of China
    Leuk Res 26:281-8. 2002
    ....
  69. ncbi [Research progress in the reversion of traditional Chinese medicine on multidrug resistance of tumor]
    Xiang Rong Song
    West China College of Pharmacy, Sichuan University, Chengdu 610041, China
    Zhongguo Zhong Yao Za Zhi 30:1300-4. 2005
    ..This paper reviews the research progress in the reversion of MDR of leukemia, hepatocarcinoma, breast carcinoma and oral epithelioid neoplasia by TDM compound, its extracts, its groups of active ingredients or its active ingredients...
  70. ncbi [Multidrug resistance in chronic lymphocytic leukemia]
    Tamás Szendrei
    Pecsi Tudomanyegyetem, Orvostudományi és Egészségtudományi Centrum I Belgyógyászati Klinika, Hematológiai Osztály, Pecs, Hungary
    Orv Hetil 149:161-7. 2008
    ....
  71. ncbi Bisphosphonates induce apoptosis in CLL cells independently of MDR phenotype
    Karina Lani Silva
    Laboratório de Hematologia Celular e Molecular, Servico de Hematologia, Hospital do Cancer I, Instituto Nacional de Cancer, Praca Cruz Vermelha 23, 6 andar, Centro, Rio de Janeiro, RJ, CEP 20230 130, Brazil
    Cancer Chemother Pharmacol 62:165-71. 2008
    ....
  72. ncbi Reversal of cancer multidrug resistance by green tea polyphenols
    Yuying Mei
    Department of Molecular and Cellular Biochemistry, 240 Combs building, Chandler Medical Center, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA
    J Pharm Pharmacol 56:1307-14. 2004
    ..Down-regulation of MDR1 gene expression was the main effect, which resulted in the reversal effect of TP on the MDR phenotype. TP is a potent MDR modulator with potential in the treatment of P-glycoprotein mediated MDR cancers...
  73. ncbi [Screening effective sequences of small interfering RNAs targeting MDR1 gene in human gastric cancer SGC7901/VCR cells]
    Fu lian Gao
    Department of Histology and Embryology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450052, China
    Zhonghua Zhong Liu Za Zhi 28:178-82. 2006
    ..To screen effective sequences of small interfering RNA targeting MDR1 gene in human gastric cancer SGC7901/VCR cells...
  74. ncbi Peloruside A does not bind to the taxoid site on beta-tubulin and retains its activity in multidrug-resistant cell lines
    Thomas N Gaitanos
    School of Biological Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand
    Cancer Res 64:5063-7. 2004
    ..It was concluded that peloruside and laulimalide have binding properties that are distinct from other microtubule-stabilizing compounds currently under investigation...
  75. ncbi Multidrug resistance gene 1 expression in salivary gland adenocarcinomas and oral squamous-cell carcinomas
    T Uematsu
    Department of Oral and Maxillofacial Surgery, Matsumoto Dental University School of Dentistry, Shiojiri, Nagano 399-0781, Japan
    Int J Cancer 92:187-94. 2001
    ....
  76. ncbi Sequential gene expression of P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and lung resistance protein: functional activity of P-gp and MRP present in the doxorubicin-resistant human K562 cell lines
    F Grandjean
    , UMR 6101, CNRS, , 87025 Limoges Cedex, France
    Anticancer Drugs 12:247-58. 2001
    ..A surprising progressive disappearance of LRP in both resistant cells suggested that the original mechanism of drug redistribution may be operative, involving a negative role for LRP...
  77. ncbi [Reversing multidrug resistance in breast cancer cell line MCF-7/ADR by small interfering RNA]
    Chen Bin Li
    Oncology Center Laboratory, Cancer Hospital, Tianjin Medical University, Tianjin 300060, P R China
    Ai Zheng 23:1605-10. 2004
    ..This study was to explore the feasibility of silencing mdr1 gene by small interfering RNA (siRNA) in drug resistant breast cancer cell line MCF-7/ADR...
  78. ncbi Daunorubicin efflux assay in determining multidrug resistance of patients with acute myeloid leukemia
    Dong Hwan Kim
    Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea
    Leuk Lymphoma 46:63-70. 2005
    ..021) and Efflux (P < 0.001). Efflux was the most reliable method in predicting an achievement of CR and stratifying the patients according to the prognosis in terms of OS and LFS in AML...
  79. ncbi Sequencing and tissue distribution of the canine MRP2 gene compared with MRP1 and MDR1
    S Conrad
    Food Chemistry Environmental Toxicology, University of Kaiserslautern, Erwin Schroedinger Strasse 52, D 67663 Kaiserslautern, Germany
    Toxicology 156:81-91. 2001
    ..The knowledge of the tissue distribution pattern of these transporters will aid to interpret pharmacokinetic and toxicokinetic data gained from dog studies and to extrapolate them to humans...
  80. pmc Reversing multidrug resistance by RNA interference through the suppression of MDR1 gene in human hepatoma cells
    Xiao Ping Chen
    Department of Surgery and Hepatic Surgery Center, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
    World J Gastroenterol 12:3332-7. 2006
    ..To reverse the multidrug resistance (MDR) by RNA interference (RNAi)-mediated MDR1 suppression in hepatoma cells...
  81. ncbi The effect of point mutations in dihydrofolate reductase genes and multidrug resistance gene 1-86 on treatment of falciparum malaria in Sudan
    Rahma Udu Yusuf
    Kenya Medical Research Institute, Centre for Biotechnology Research and Development, KEMRI Nairobi, Kenya
    J Infect Dev Ctries 4:61-9. 2010
    ..falciparum isolates, involving the detection of mutations at the mdr 1- 86 which associates with amodiaquine resistance, and dhfr mutations associated with SP resistances...
  82. ncbi Efficacy of artesunate plus amodiaquine versus that of artemether-lumefantrine for the treatment of uncomplicated childhood Plasmodium falciparum malaria in Zanzibar, Tanzania
    Andreas Martensson
    Infectious Diseases Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
    Clin Infect Dis 41:1079-86. 2005
    ..Children who were 9-59 months of age and who weighted > or =9 kg were randomly assigned to receive either ASAQ or AL for 3 days in standard doses. Intention-to-treat analyses were performed...
  83. ncbi Technetium-99m sestamibi single photon emission computed tomography findings correlated with P-glycoprotein expression, encoded by the multidrug resistance gene-1 messenger ribonucleic acid, in intracranial meningiomas
    Katsuzo Kunishio
    Department of Neurological Surgery, Kagawa Medical University, Kagawa
    Neurol Med Chir (Tokyo) 43:573-80; discussion 581. 2003
    ....
  84. ncbi Functional characterization of the rat mdr1b encoded P-glycoprotein: not all inducing agents are substrates
    E Santoni-Rugiu
    Division of Basic Sciences, National Cancer Institute, Bethesda, MD 20892, USA
    Carcinogenesis 18:2255-63. 1997
    ..The fact that compounds which are not themselves substrates can induce P-glycoprotein expression may have implications for pharmacokinetic interactions and chemotherapy...
  85. ncbi Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia
    Guillermo Garcia-Manero
    Department of Leukemia, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 97:695-702. 2003
    ..This epigenetic modification has been associated with gene silencing, malignant transformation, and aging. It is not known whether there are epigenetic differences between pediatric patients and adult patients with ALL...
  86. pmc Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells
    M Raymond
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 10:1642-51. 1990
    ..cDNA subfragments corresponding to discrete regions showing little sequence conservation among the three mdr genes were used as gene-specific DNA probes in hybridization experiments...
  87. ncbi Estrogen receptor alpha inhibits p53-mediated transcriptional repression: implications for the regulation of apoptosis
    Aejaz Sayeed
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 67:7746-55. 2007
    ..The findings could have translational implications in developing new therapeutic and prevention strategies against breast cancer...
  88. ncbi Transfection of mu MDR 1 inhibits Na(+)-independent Cl-/-HCO3 exchange in Chinese hamster ovary cells
    J G Luz
    Program in Molecular Pharmacology and Therapeutics, Memorial Sloan Kettering Cancer Center, Cornell University, New York, New York 10021
    Biochemistry 33:7239-49. 1994
    ..Northern and western blot analyses confirm the substantial overexpression of the mu MDR genes and proteins in these lines, as well as the mild overexpression of endogenous hamster p-GP mRNA in some lines...
  89. ncbi Inhibition of the mitogen-activated protein kinase pathway results in the down-regulation of P-glycoprotein
    Kazuhiro Katayama
    Department of Chemotherapy, Kyoritsu University of Pharmacy, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Mol Cancer Ther 6:2092-102. 2007
    ..Furthermore, U0126-treated cells showed high levels of rhodamine123 uptake. Hence, our present data show that inhibition of the MEK-ERK-RSK pathway down-regulates P-gp expression levels and diminishes the cellular multidrug resistance...
  90. ncbi Drug-resistance gene expression and progression of astrocytic tumors
    S Tanaka
    Department of Neurosurgery, Kitasato Institute Medical Center Hospital, Kitamoto, Saitama, Japan
    Brain Tumor Pathol 18:131-7. 2001
    ..These findings suggest that native drug resistance is more important than acquired resistance when glioma therapy is considered...
  91. ncbi RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response
    Herman Burger
    Department of Medical Oncology, Erasmus Medical Center Rotterdam Daniel den Hoed Kliniek Josephine Nefkens Institute, 3000 DR Rotterdam, The Netherlands
    Clin Cancer Res 9:827-36. 2003
    ..The aim of this study was to investigate whether expression of particular drug resistance genes in primary operable breast cancer correlates with response to first-line chemotherapy in advanced disease...
  92. ncbi [Correlation of chemosensitivity tested using histoculture drug response assay to expression of multidrug resistance genes and proteins in colorectal cancer tissues]
    Shu Qiang Yuan
    State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, PR China
    Ai Zheng 28:932-8. 2009
    ....
  93. ncbi Promoter methylation of glutathione S-transferase pi1 and multidrug resistance gene 1 in bronchioloalveolar carcinoma and its correlation with DNA methyltransferase 1 expression
    Peng Gao
    Department of Pathology, School of Medicine, Shandong University, Jinan, People s Republic of China
    Cancer 115:3222-32. 2009
    ....
  94. pmc No seasonal accumulation of resistant P. falciparum when high-dose chloroquine is used
    Johan Ursing
    Malaria Research, Department of Infectious Diseases, Karolinska Hospital, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 4:e6866. 2009
    ..falciparum with pfcrt 76T commonly survive treatment with normal dose chloroquine. In Guinea-Bissau, there should be no seasonal increase of pfcrt 76T if the high doses of CQ commonly used are effective...
  95. ncbi DNA methylation patterns at relapse in adult acute lymphocytic leukemia
    Guillermo Garcia-Manero
    Department of Leukemia, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Clin Cancer Res 8:1897-903. 2002
    ..To study the role of DNA methylation in relapse mechanisms in acute lymphocytic leukemia (ALL), we have compared the methylation status of five genes at the time of initial presentation and at first relapse in 25 adult patients with ALL...
  96. ncbi Retinol-induced mdr1 and mdr3 modulation in cultured rat Sertoli cells is attenuated by free radical scavengers
    Mário Luiz Conte da Frota
    Centro de Estudos em Estresse Oxidativo CEEO, ICBS UFRGS, Porto Alegre, Brazil
    Redox Rep 9:161-5. 2004
    The effects of retinol on modulation of mdr genes in Sertoli cells were investigated. The hypothesis that free radical scavengers may attenuate the effect of retinol was also tested...
  97. ncbi Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: a phase III trial (E2995)
    Peter L Greenberg
    Hematology Division, Stanford University Medical Center, 703 Welch Rd, Suite G 1, Stanford, CA 94305, USA
    J Clin Oncol 22:1078-86. 2004
    ....
  98. ncbi Three distinct nuclear protein binding sites in the promoter of the murine multidrug resistance mdr1b gene
    L Yu
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 268:7520-6. 1993
    ..cells is often associated with the overproduction of a membrane glycoprotein, P-glycoprotein, that is encoded by mdr genes. Multidrug resistance cell lines selected with either vinblastine, colchicine, or taxol from the drug-sensitive ..
  99. ncbi Expression of P-glycoprotein in HeLa cells confers resistance to ceramide cytotoxicity
    Jacqueline V Chapman
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    Int J Oncol 37:1591-7. 2010
    ..We propose that P-gp can be an effective target for enhancing short-chain ceramide cytotoxicity in the treatment of drug-resistant cancer...
  100. ncbi Increased expression of lung resistance-related protein in lower grade urothelial carcinoma of the renal pelvis and ureter
    Chui Ze Kong
    Department of Urology, The First Affiliated Hospital of China Medical University, Shenyang, China
    Int J Urol 11:721-7. 2004
    ..We investigated the protein and mRNA expression levels of LRP, MDR1 and MRP1 in this malignancy and the clinical significance of their expression was evaluated...
  101. pmc Different vimentin expression in two clones derived from a human colocarcinoma cell line (LoVo) showing different sensitivity to doxorubicin
    G Conforti
    Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy
    Br J Cancer 71:505-11. 1995
    ....

Research Grants43

  1. Signaling Pathways in Yeast Azole Response
    Thomas Edlind; Fiscal Year: 2005
    ..Finally, the signalling pathway responsible for azole-dependent upregulation of ERG expression will be elucidated with a focus on Rox1p and Haplp transcription factors. ..
  2. Evaluation of novel cytotoxic compounds for immunoconjugates
    STANLEY BELL; Fiscal Year: 2007
    ..that can be linked to tumor specific antibodies will provide enhanced treatment options for cancer patients. [unreadable] [unreadable] [unreadable]..
  3. GENETIC BASIS OF DRUG RESISTANCE IN P FALCIPARUM
    Dyann Wirth; Fiscal Year: 1991
    ..This resistance is mediated by the amplification of mdr genes encoding a high molecular weight plasma membrane P-glycoprotein...
  4. Mechanisms of Resistance to Gemtuzumab Ozogamicin
    Irwin Bernstein; Fiscal Year: 2006
    ..Thus, we propose to determine the role of MDR genes in inhibiting the cytotoxic effects of GO; and the effect of agents that reverse drug resistance, such as CSA, ..
  5. Chromatin-based regulation of multidrug resistance genes
    Karl Henry; Fiscal Year: 2006
    ..data that are generated from this initial research proposal may prove useful for understanding the control of MDR genes and reveal novel drug targets for antifungal therapy...
  6. DEVELOPING NEW TOOLS FOR ANTIBACTERIAL DRUG DISCOVERY
    Bruce Rogers; Fiscal Year: 1999
    ..definition and public availability of the complete genome sequence that allows for an assignment of potential MDR genes followed by PCR amplification and gene disruption. There are four putative MDR pumps in S. pneumoniae...
  7. MOLECULAR GENETICS OF MULTIDRUG RESISTANCE
    David Housman; Fiscal Year: 1990
    ..5. To relate gene expression patterns of mdr genes in normal cells to the metabolism by these cells of drugs belonging to the mdr spectrum. 6...
  8. Canine model for assessing CNS access P-gp substrates
    KATRINA MEALEY; Fiscal Year: 2005
    ....
  9. CNS Viral Dynamics and Cellular Immunity During AIDS
    David Haas; Fiscal Year: 2009
    ..Characterizing these relationships will expand our knowledge regarding key events that lead to AIDS dementia, and may suggest novel approaches to other immunologic or viral-mediated diseases that affect the brain. ..
  10. Phase1/11 study of 5-aza-2'-deoxycytidine and valproic *
    Guillermo Garcia Manero; Fiscal Year: 2005
    ..Decitabine will be generously provided by SuperGen (r). Valproic acid is an FDA approved anti-convulsant. ..
  11. Cell Cycle Controlling Genes in Adult Acute Lymphoma
    Guillermo Garcia Manero; Fiscal Year: 2005
    ..abstract_text> ..
  12. Validation of rat models for resistant epilepsy therapy
    Wolfgang Loscher; Fiscal Year: 2005
    ..Our goal is to establish standard assays that can be employed by researchers to continue the search for treatments of drug resistant epilepsy. ..
  13. Targeted Prodrug Therapy of Liver Cancers
    MACUS KUO; Fiscal Year: 2005
    ....
  14. VANDERBILT ADULT AIDS CLINICAL TRIALS UNIT
    David Haas; Fiscal Year: 2006
    ..The proposed ACTU will not only enroll patients into ACTG clinical trials, but will provide the ACTG the ability to address important questions concerning AIDS treatment and pathogenesis. ..
  15. REGULATION OF MDR GENE EXPRESSION IN LIVER CANCERS
    MACUS KUO; Fiscal Year: 2004
    ..We hope from this research, which includes in vitro cell culture and in vivo animal and tumor models, to gain important molecular insights into the genetic resolution of drug resistance and hepatocarcinogenesis. ..
  16. Genomic Instability and Evolution of Drug Resistance
    MACUS KUO; Fiscal Year: 2008
    ..We anticipate from these studies to gain important insights into the function of FSA in the regulation of cell growth and differentiation in normal and malignant epithelial cells. ..
  17. Phase I study of 5-aza-2?-deoxycitidine in acute lymphocytic leukemia
    Guillermo Garcia Manero; Fiscal Year: 2008
    ..In this proposal, we plan to develop a new form of low-dose chemotherapy, decitabine, for these patients. Early results indicate that this is active and safe. [unreadable] [unreadable] [unreadable]..
  18. Redox Regulation of Multidrug Resistance Gene Expression
    MACUS KUO; Fiscal Year: 2009
    ..We hope from these studies to learn the molecular bases of redox conditions that affect drug sensitivity through the regulation of their respective drug resistance gene expression. ..
  19. Lung Cancer Chemoradiation: Predictors of Survival
    Xifeng Wu; Fiscal Year: 2009
    ..This multivariate prognostic study could have long-term prognostic potential by allowing greater individualization of therapy, based on the genetic makeup of the patient, thereby both increasing efficacy and reducing morbidity. ..
  20. Serum markers of brain barriers
    Damir Janigro; Fiscal Year: 2010
    ..Finally, we will validate the usefulness of these markers in the early detection of recurrent brain tumors or metastases, to specifically address one of the mandates of this PA. ..
  21. CD44/VARIANT CYTOSKELETON IN BREAST CANCER PROGRESSION
    LILLY YW BOURGUIGNON; Fiscal Year: 2010
    ....
  22. COORDINATED REGULATION OF ANTIOXIDANT ENZYMES
    Michael Kelner; Fiscal Year: 2005
    ..abstract_text> ..
  23. Clinical Assessment of Herb-Drug Interactions
    Bill Gurley; Fiscal Year: 2005
    ..e. CYPIA2, CYP2D6 and CYP3A4); and (3) whether prolonged herb use can modulate P-gp-mediated drug absorption and elimination. ..
  24. MECHANISMS OF SELECTIVE ACTIONS OF ANTIVIRAL AGENTS
    Ram Agarwal; Fiscal Year: 2003
    ..HIV sensitivity to 3TC, ddC, and AZT in the resistant cells will be examined by p24 analysis. Understanding of these factors will help design strategies to improve effectiveness of the antiviral agents. ..
  25. GENETIC INFLUENCE ON MUTAGEN SENSITIVITY--A TWIN STUDY
    Xifeng Wu; Fiscal Year: 2004
    ..Additionally, these potential biomarkers may ultimately be used to identify individuals who should be targeted for more intense screening programs or behavior modification interventions. ..
  26. Genomics Screening for Antiangiogenesis Drugs
    John Fruehauf; Fiscal Year: 2002
    ..The total global market size for anti-angiogenesis drugs in cancer could reach $ 3 billion by 2005...
  27. HEPATOBILIARY DISPOSITION IN TOXICOLOGY
    Curtis Klaassen; Fiscal Year: 2003
    ..abstract_text> ..
  28. HETEROGENEITY OF HIPPOCAMPAL GLIA
    Damir Janigro; Fiscal Year: 2002
    ..The outcome of the proposed experiments may be useful for further extrapolations applicable to other physiological aspects of glia(c)neuronal interactions. ..
  29. Environmental Hormones: Effects on Thyroid Function
    Curtis Klaassen; Fiscal Year: 2005
    ..abstract_text> ..
  30. Halogenated Alkenes and Microsomal GSH-transferases
    Michael J Kelner; Fiscal Year: 2010
    ..4] To determine the relative contribution of MGST1 and MGST2 to cellular antioxidant capacity through studies utilizing human MGST1 and MGST2 null cells. ..
  31. Regulation of Hepatic Excretion of Xenobiotics by Mrps
    Curtis D Klaassen; Fiscal Year: 2010
    ..Elucidation of the role of Nrf2 in the regulation of the efflux transport process will have significant ramifications in toxicology, xenobiotics disposition, drug-drug interaction, and cancer chemoprevention. ..
  32. GPX1 ENZYME REGULATION BY OXIDATIVE XENOBIOTICS
    Michael Kelner; Fiscal Year: 2002
    ..These studies will provide critical information regarding cellular response to oxidative stress and aid in determining if a common regulatory mechanism exists for GSH-dependent enzymes. ..
  33. Coordinate Regulation of Uptake and Efflux Transporters
    Curtis D Klaassen; Fiscal Year: 2010
    ....
  34. Role of MUC1 in Pancreatic Cancer
    Pinku Mukherjee; Fiscal Year: 2010
    ..This project is extremely relevant to pancreatic cancer. These preclinical studies will form the basis for designing more efficacious and novel therapies to combat the mortality associated with PDA. ..
  35. REGULATION OF CEREBRAL BLOOD FLOW BY ATP
    Damir Janigro; Fiscal Year: 2003
    ..2) To elucidate the mechanisms of potassium-mediated dilations in vivo. These studies will allow better understanding on neuronal-vascular interactions and will open new perspectives for the treatment of neurological diseases. ..
  36. Markers of Genetic Susceptibility to Bladder Cancer
    Xifeng Wu; Fiscal Year: 2008
    ..The ability to rapidly screen individuals for risk, using minimally invasive procedures (blood samples), has immense clinical implication, such as intensive screening and chemopreventive interventions. ..
  37. MDR-1 EXPRESSION IN INFLAMMATORY BOWEL DISEASE
    Richard Farrell; Fiscal Year: 2004
    ....
  38. Genetic Susceptibility Modifiers in Renal Cell Carcinoma
    Xifeng Wu; Fiscal Year: 2007
    ..Such individuals may then be targeted for intervention programs such as chemoprevention or dietary modification. ..
  39. Mediators of Blood-Brain Barrier Disruption
    Damir Janigro; Fiscal Year: 2007
    ..g. Alzheimer's, demyelinating diseases, brain tumors). [unreadable] [unreadable]..
  40. Crohn's Disease Gene Mapping of Chromosome 16
    STEVEN BRANT; Fiscal Year: 2005
    ..Defining the IBD1 mutation for CD will be a major step in unraveling the etiology and pathophysiology of this enigmatic disease, improve genetic counseling and make possible novel preventative and therapeutic strategies. ..
  41. MECHANISMS OF MULTIDRUG RESISTANCE
    Damir Janigro; Fiscal Year: 2005
    ..In particular, we are investigating how changes in blood-brain barrier function may drive glia and neurons into an "epileptic" phenotype. ..
  42. Identifying Disease Variants for Familial Crohns Disease
    Steven R Brant; Fiscal Year: 2010
    ..With this study, we will test 9000 gene markers in these regions and identify the specific genes and, by gene sequencing, the specific DNA abnormalities that result in a significant proportion of familial Crohn's disease. ..
  43. CD44-P185HER2 INTERACTION IN OVARIAN CANCER PROGRESSION
    LILLY BOURGUIGNON; Fiscal Year: 2007
    ..abstract_text> ..