fungal genes


Summary: The functional hereditary units of FUNGI.

Top Publications

  1. ncbi Functional profiling of the Saccharomyces cerevisiae genome
    Guri Giaever
    Stanford Genome Technology Center, Stanford University, Palo Alto, California 94304, USA
    Nature 418:387-91. 2002
  2. ncbi Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
    Jörg Kämper
    Department of Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Nature 444:97-101. 2006
  3. pmc The transcriptional landscape of the yeast genome defined by RNA sequencing
    Ugrappa Nagalakshmi
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Science 320:1344-9. 2008
  4. ncbi The genome sequence of the rice blast fungus Magnaporthe grisea
    Ralph A Dean
    Center for Integrated Fungal Research, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nature 434:980-6. 2005
  5. ncbi The genome sequence of the filamentous fungus Neurospora crassa
    James E Galagan
    Whitehead Institute Center for Genome Research, 320 Charles Street, Cambridge, Massachusetts 02141, USA
    Nature 422:859-68. 2003
  6. ncbi Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
    William C Nierman
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Nature 438:1151-6. 2005
  7. ncbi Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS
    C J Gimeno
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142
    Cell 68:1077-90. 1992
  8. pmc Transcriptional response of Candida albicans upon internalization by macrophages
    Michael C Lorenz
    Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center, 6431 Fannin, Houston, TX 77030, USA
    Eukaryot Cell 3:1076-87. 2004
  9. ncbi Systematic genetic analysis with ordered arrays of yeast deletion mutants
    A H Tong
    Banting and Best Department of Medical Research, University of Toronto, Toronto ON, Canada M5G 1L6
    Science 294:2364-8. 2001
  10. ncbi Evolutionary rate in the protein interaction network
    Hunter B Fraser
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Science 296:750-2. 2002

Detail Information

Publications339 found, 100 shown here

  1. ncbi Functional profiling of the Saccharomyces cerevisiae genome
    Guri Giaever
    Stanford Genome Technology Center, Stanford University, Palo Alto, California 94304, USA
    Nature 418:387-91. 2002
    ..Our results validate the yeast gene-deletion collection as a valuable resource for functional genomics...
  2. ncbi Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
    Jörg Kämper
    Department of Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Nature 444:97-101. 2006
    ..Genomic analysis is, similarly, likely to open up new avenues for the discovery of virulence determinants in other pathogens...
  3. pmc The transcriptional landscape of the yeast genome defined by RNA sequencing
    Ugrappa Nagalakshmi
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Science 320:1344-9. 2008
    ..We also found unexpected 3'-end heterogeneity and the presence of many overlapping genes. These results indicate that the yeast transcriptome is more complex than previously appreciated...
  4. ncbi The genome sequence of the rice blast fungus Magnaporthe grisea
    Ralph A Dean
    Center for Integrated Fungal Research, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nature 434:980-6. 2005
    ..The M. grisea genome has been subject to invasion and proliferation of active transposable elements, reflecting the clonal nature of this fungus imposed by widespread rice cultivation...
  5. ncbi The genome sequence of the filamentous fungus Neurospora crassa
    James E Galagan
    Whitehead Institute Center for Genome Research, 320 Charles Street, Cambridge, Massachusetts 02141, USA
    Nature 422:859-68. 2003
    ..Genome analysis suggests that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes...
  6. ncbi Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
    William C Nierman
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Nature 438:1151-6. 2005
    ..The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus...
  7. ncbi Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS
    C J Gimeno
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142
    Cell 68:1077-90. 1992
    ..Constitutive activation of RAS2 or mutation of SHR3, a gene required for amino acid uptake, enhance the pseudohyphal phenotype; a dominant mutation in RSR1/BUD1 that causes random budding suppresses pseudohyphal growth...
  8. pmc Transcriptional response of Candida albicans upon internalization by macrophages
    Michael C Lorenz
    Department of Microbiology and Molecular Genetics, The University of Texas Health Science Center, 6431 Fannin, Houston, TX 77030, USA
    Eukaryot Cell 3:1076-87. 2004
  9. ncbi Systematic genetic analysis with ordered arrays of yeast deletion mutants
    A H Tong
    Banting and Best Department of Medical Research, University of Toronto, Toronto ON, Canada M5G 1L6
    Science 294:2364-8. 2001
    ..Systematic application of this approach should produce a global map of gene function...
  10. ncbi Evolutionary rate in the protein interaction network
    Hunter B Fraser
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Science 296:750-2. 2002
    ..We confirm one predicted outcome of this process-namely, that interacting proteins evolve at similar rates...
  11. ncbi Genome sequence of the lignocellulose degrading fungus Phanerochaete chrysosporium strain RP78
    Diego Martinez
    US DOE Joint Genome Institute, Walnut Creek, California 94598, USA
    Nat Biotechnol 22:695-700. 2004
    ..This genome provides a high quality draft sequence of a basidiomycete, a major fungal phylum that includes important plant and animal pathogens...
  12. ncbi Using Bayesian networks to analyze expression data
    N Friedman
    School of Computer Science and Engineering, Hebrew University, Jerusalem, Israel
    J Comput Biol 7:601-20. 2000
    ..We then describe a method for recovering gene interactions from microarray data using tools for learning Bayesian networks. Finally, we demonstrate this method on the S. cerevisiae cell-cycle measurements of Spellman et al. (1998)...
  13. ncbi Dissecting the architecture of a quantitative trait locus in yeast
    Lars M Steinmetz
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 416:326-30. 2002
    ..It also demonstrates a deficiency in current approaches to QTL dissection with implications extending to traits in other organisms, including human genetic diseases...
  14. ncbi Evidence for dynamically organized modularity in the yeast protein-protein interaction network
    Jing Dong J Han
    Center for Cancer Systems Biology and Department of Cancer Biology, Dana Farber Cancer Institute, and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 430:88-93. 2004
  15. pmc Genetic interactions between polymorphisms that affect gene expression in yeast
    Rachel B Brem
    Program in Computational Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B876, Seattle, Washington 98109, USA
    Nature 436:701-3. 2005
    ..Our results indicate that genetic interactions are widespread in the genetics of transcript levels, and that many QTLs will be missed by single-locus tests but can be detected by two-stage tests that allow for interactions...
  16. pmc Aneuploidy and isochromosome formation in drug-resistant Candida albicans
    Anna Selmecki
    Department of Genetics, Cell Biology, and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Science 313:367-70. 2006
  17. pmc The chemical genomic portrait of yeast: uncovering a phenotype for all genes
    Maureen E Hillenmeyer
    Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA
    Science 320:362-5. 2008
    ..We found that 97% of gene deletions exhibited a measurable growth phenotype, suggesting that nearly all genes are essential for optimal growth in at least one condition...
  18. pmc Evolution of pathogenicity and sexual reproduction in eight Candida genomes
    Geraldine Butler
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Nature 459:657-62. 2009
    ..Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes...
  19. ncbi A gene-coexpression network for global discovery of conserved genetic modules
    Joshua M Stuart
    Stanford Medical Informatics, 251 Campus Drive, Medical School Office Building X 215, Stanford, CA 94305 5329, USA
    Science 302:249-55. 2003
    ..By assembling these links into a gene-coexpression network, we found several components that were animal-specific as well as interrelationships between newly evolved and ancient modules...
  20. ncbi Prions affect the appearance of other prions: the story of [PIN(+)]
    I L Derkatch
    Laboratory for Molecular Biology, Department of Biological Sciences, University of Illinois at Chicago, 900 South Ashland Avenue, Chicago, IL 60607, USA
    Cell 106:171-82. 2001
    ..Importantly, the de novo appearance of Rnq1::GFP prion aggregates also requires the presence of other prions, suggesting the existence of a general mechanism by which the appearance of prions is enhanced by heterologous prion aggregates...
  21. ncbi Genetic dissection of transcriptional regulation in budding yeast
    Rachel B Brem
    Fred Hutchinson Cancer Research Center FHCRC, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109, USA and Howard Hughes Medical Institute
    Science 296:752-5. 2002
    ..We found eight such trans-acting loci, each affecting the expression of a group of 7 to 94 genes of related function...
  22. ncbi Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution
    Brian T Wilhelm
    Cancer Research UK Fission Yeast Functional Genomics Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1HH, UK
    Nature 453:1239-43. 2008
    ..Splicing efficiency was largely coordinated with transcript levels, and increased transcription led to increased splicing in test genes. Hundreds of introns showed such regulated splicing during cellular proliferation or differentiation...
  23. pmc A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae
    V Guacci
    Howard Hughes Medical Institute, Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Cell 91:47-57. 1997
    ..These data implicate Mcd1p as a nexus between cohesion and condensation. We present a model for mitotic chromosome structure that incorporates this previously unsuspected link...
  24. ncbi Genome sequencing and analysis of Aspergillus oryzae
    Masayuki Machida
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Higashi 1 1 1, Tsukuba, Ibaraki 305 8566, Japan
    Nature 438:1157-61. 2005
    ..Specific expansion of genes for secretory hydrolytic enzymes, amino acid metabolism and amino acid/sugar uptake transporters supports the idea that A. oryzae is an ideal microorganism for fermentation...
  25. pmc LaeA, a regulator of morphogenetic fungal virulence factors
    Jin Woo Bok
    University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Eukaryot Cell 4:1574-82. 2005
    ..LaeA, a conserved protein in filamentous fungi, is a developmental regulator of virulence genes and, possibly, the first antimicrobial target specific to filamentous fungi that are pathogenic to plants and animals...
  26. pmc Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases
    J S Robinson
    Division of Biology, California Institute of Technology, Pasadena 91125
    Mol Cell Biol 8:4936-48. 1988
    ..Together, these data indicate that more than 50 gene products are involved, directly or indirectly, in the process of vacuolar protein sorting...
  27. ncbi Genome-scale approaches to resolving incongruence in molecular phylogenies
    Antonis Rokas
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, R M Bock Laboratories, University of Wisconsin Madison, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    Nature 425:798-804. 2003
    ..These results have important implications for resolving branches of the tree of life...
  28. ncbi The chronological life span of Saccharomyces cerevisiae
    Paola Fabrizio
    Andrus Gerontology Center, Division of Biogerontology and Department of Biological Sciences, University of Southern California, Los Angeles 90089 0191, USA
    Aging Cell 2:73-81. 2003
    ..We will review the yeast S. cerevisiae model system with emphasis on the chronological life span as a model system to study aging and the regulation of stress resistance in eukaryotes...
  29. ncbi Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery
    Terry Roemer
    Elitra Canada, Montreal, Quebec, Canada, H2X 3Y8
    Mol Microbiol 50:167-81. 2003
    ..albicans essential gene set, and their respective conditional mutant strains may be directly used as sensitive whole-cell assays for drug screening...
  30. ncbi nmt1 of fission yeast. A highly transcribed gene completely repressed by thiamine
    K Maundrell
    Sclavo Research Centre, Siena, Italy
    J Biol Chem 265:10857-64. 1990
    ..The nmt1 promotor has been subcloned, and thiamine-mediated transcriptional control has been transferred to the bacterial reporter gene chloramphenicol acetyltransferase...
  31. ncbi White-opaque switching in Candida albicans is controlled by mating-type locus homeodomain proteins and allows efficient mating
    Mathew G Miller
    Department of Microbiology and Immunology, University of California, San Francisco 94143, USA
    Cell 110:293-302. 2002
    ..As white cells are generally more robust in a mammalian host than are opaque cells, this strategy allows the organism to survive the rigors of life within a mammalian host, yet generate mating-competent cells...
  32. ncbi Global mapping of the yeast genetic interaction network
    Amy Hin Yan Tong
    Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, Canada M5G 1L6
    Science 303:808-13. 2004
    ..Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms...
  33. ncbi Quantitative trait loci mapped to single-nucleotide resolution in yeast
    Adam M Deutschbauer
    Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Genet 37:1333-40. 2005
    ..Our results provide the highest resolution to date of the molecular basis of a quantitative trait, showing that the interaction of a few genetic variants can have a profound phenotypic effect...
  34. ncbi CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast
    Michael Costanzo
    Department of Medical Genetics and Microbiology, University of Toronto, 1 King s College Circle, Toronto, M5S 1A8, Canada
    Cell 117:899-913. 2004
    ..Elimination of CDK activity at the end of mitosis allows Whi5 to reenter the nucleus to again repress G1/S transcription. These findings harmonize G1/S control in eukaryotes...
  35. ncbi The veA gene activates sexual development in Aspergillus nidulans
    Hee Kim
    Basic Science Research Institute, Division of Biological Sciences, Chonbuk National University, Chonju, Chonbuk 561 756, Republic of Korea
    Fungal Genet Biol 37:72-80. 2002
    ..These results indicated that the veA gene is a positive regulator in sexual development and simultaneously a negative one in asexual development...
  36. ncbi Bioinformatic and expression analysis of the putative gliotoxin biosynthetic gene cluster of Aspergillus fumigatus
    Donald M Gardiner
    School of Botany, The University of Melbourne, VIC 3010, Australia
    FEMS Microbiol Lett 248:241-8. 2005
    ..The physical limits of the cluster in A. fumigatus have been defined by bioinformatics and by identifying the genes that are co-regulated and whose timing of expression correlates with the production of gliotoxin in culture...
  37. ncbi Genome evolution in yeasts
    Bernard Dujon
    Unité de Génétique Moléculaire des Levures, URA 2171 CNRS and UFR 927 Université Pierre et Marie Curie
    Nature 430:35-44. 2004
  38. pmc Osmotic stress signaling and osmoadaptation in yeasts
    Stefan Hohmann
    Department of Cell and Molecular Biology Microbiology, Goteborg University, S 405 30 Goteborg, Sweden
    Microbiol Mol Biol Rev 66:300-72. 2002
  39. ncbi Genome-wide genetic analysis of polyploidy in yeast
    Zuzana Storchova
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 443:541-7. 2006
    ..Thus, geometric constraints may have profound effects on genome stability; the phenomenon described here may be relevant in a variety of biological contexts, including disease states such as cancer...
  40. ncbi Multiple Gln/Asn-rich prion domains confer susceptibility to induction of the yeast [PSI(+)] prion
    L Z Osherovich
    Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cell 106:183-94. 2001
    ..These studies suggest a molecular basis for the epigenetic control of [PSI(+)] inducibility and may reveal a broader role for this phenomenon in the physiology of protein aggregation...
  41. pmc PHI-base: a new database for pathogen host interactions
    Rainer Winnenburg
    Biomathematics and Bioinformatics Division, Rothamsted Research, Harpenden, AL5 2JQ, UK
    Nucleic Acids Res 34:D459-64. 2006
    ..g. NCBI taxonomy and EMBL). We welcome new data for inclusion in PHI-base, which is freely accessed at
  42. pmc Transcription profiling of Candida albicans cells undergoing the yeast-to-hyphal transition
    Andre Nantel
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada H4P 2R2
    Mol Biol Cell 13:3452-65. 2002
    ..Thus Efg1p and Cph1p are needed for the activation of the transcriptional program that is induced by the presence of serum...
  43. pmc TUP1, CPH1 and EFG1 make independent contributions to filamentation in candida albicans
    B R Braun
    Department of Microbiology, University of California, San Francisco, California 94143 0414, USA
    Genetics 155:57-67. 2000
    ..The results suggest the existence of several distinct types of filamentous forms of C. albicans, each dependent on a particular set of environmental conditions and each expressing a unique set of surface proteins...
  44. pmc Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape
    H Sesaki
    Department of Cell Biology and Anatomy, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Cell Biol 147:699-706. 1999
    ..Our results thus suggest that mitochondrial shape is normally controlled by a balance between division and fusion which requires Dnm1p and Fzo1p, respectively...
  45. ncbi Exploring the metabolic and genetic control of gene expression on a genomic scale
    J L DeRisi
    Department of Biochemistry, Stanford University School of Medicine, Howard Hughes Medical Institute, Stanford, CA 94305 5428, USA
    Science 278:680-6. 1997
    ..These results demonstrate the feasibility and utility of this approach to genomewide exploration of gene expression patterns...
  46. pmc Clustered pathway genes in aflatoxin biosynthesis
    Jiujiang Yu
    Southern Regional Research Center, Agricultural Research Service, U S Department of Agriculture, New Orleans, Louisiana 70124, USA
    Appl Environ Microbiol 70:1253-62. 2004
  47. pmc Genetic regulation of nitrogen metabolism in the fungi
    G A Marzluf
    Department of Biochemistry, Ohio State University, Columbus 43210, USA
    Microbiol Mol Biol Rev 61:17-32. 1997
    ..Nitrogen metabolic regulation appears to play a significant role in the pathogenicity of certain animal and plant fungal pathogens...
  48. ncbi Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor
    F Posas
    Dana Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 86:865-75. 1996
    ..We propose that the multistep phosphorelay mechanism is a universal signal transduction apparatus utilized both in prokaryotes and eukaryotes...
  49. ncbi Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae
    Manolis Kellis
    The Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 428:617-24. 2004
    ..Strikingly, 95% of cases of accelerated evolution involve only one member of a gene pair, providing strong support for a specific model of evolution, and allowing us to distinguish ancestral and derived functions...
  50. pmc The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans
    Brendan J Loftus
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 307:1321-4. 2005
    ..neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes...
  51. ncbi Role of duplicate genes in genetic robustness against null mutations
    Zhenglong Gu
    Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, Illinois 60637, USA
    Nature 421:63-6. 2003
    ..We estimate that in S. cerevisiae at least a quarter of those gene deletions that have no phenotype are compensated by duplicate genes...
  52. pmc Asexual sporulation in Aspergillus nidulans
    T H Adams
    Department of Biology, Texas A and M University, College Station 77843, USA
    Microbiol Mol Biol Rev 62:35-54. 1998
    ..A working model is presented in which the regulatory interactions between these two pathways during the fungal life cycle determine whether cells grow or develop...
  53. ncbi Noise in eukaryotic gene expression
    William J Blake
    Center for BioDynamics, Center for Advanced Biotechnology, Bioinformatics Program, and Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, Massachusetts 02215, USA
    Nature 422:633-7. 2003
    ..This result has implications for the role of noise in phenotypic variation and cellular differentiation...
  54. pmc Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae
    Akon H Enyenihi
    Department of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Genetics 163:47-54. 2003
    ..The set of genes identified in this phenotypic screen shows only limited overlap with those identified by expression-based studies...
  55. pmc The fission yeast pmk1+ gene encodes a novel mitogen-activated protein kinase homolog which regulates cell integrity and functions coordinately with the protein kinase C pathway
    T Toda
    Cell Regulation Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Mol Cell Biol 16:6752-64. 1996
    ..pombe, Pmk1 may not act in a linear manner with respect to fission yeast protein kinase C homologs. Interestingly, however, these two pathways are not independent; instead, they regulate cell integrity in a coordinate manner...
  56. pmc Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes
    Scott J Dixon
    Banting and Best Department of Medical Research and Department of Molecular Genetics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Room 1330, Toronto, ON, Canada M5S 3E1
    Proc Natl Acad Sci U S A 105:16653-8. 2008
    ..We define a conserved yeast network (CYN) composed of 106 genes and 144 interactions and suggest that this network may help understand the shared biology of diverse eukaryotic species...
  57. ncbi Cohesins: chromosomal proteins that prevent premature separation of sister chromatids
    C Michaelis
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 91:35-45. 1997
    ..Proteins homologous to Scc1p exist in a variety of eukaryotic organisms including humans. A common cohesion apparatus might be used by all eukaryotic cells during both mitosis and meiosis...
  58. pmc Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles
    Laurence Decourty
    Institut Pasteur, Genetique des Interactions Macromoleculaires, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2171, Paris Cedex 15, France
    Proc Natl Acad Sci U S A 105:5821-6. 2008
    ..These weak effects, rarely meaningful when considered individually, were crucial to defining specific signatures for many gene deletions and had a major contribution in defining clusters of functionally related genes...
  59. pmc Molecular characterization of a chromosomal rearrangement involved in the adaptive evolution of yeast strains
    José E Pérez-Ortín
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, Spain
    Genome Res 12:1533-9. 2002
    ..This is the first time that a gross chromosomal rearrangement is shown to be involved in the adaptive evolution of Saccharomyces cerevisiae...
  60. pmc Development and characterization of an in vivo central venous catheter Candida albicans biofilm model
    D Andes
    Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA
    Infect Immun 72:6023-31. 2004
    ..albicans biofilm biology and drug resistance. In addition, the model provides a means to study novel drug therapies and device technologies targeted to the control of biofilm-associated infections...
  61. ncbi Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae
    B K Kennedy
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 89:381-91. 1997
    ..We propose that the rDNA is the AGE locus and that nucleolar function is compromised in old yeast cells in a way that may be mitigated by targeting of Sir proteins to the nucleolus...
  62. ncbi A high-affinity iron permease essential for Candida albicans virulence
    N Ramanan
    Microbial Collection and Screening Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609
    Science 288:1062-4. 2000
    ..Thus, CaFTR1-mediated iron-uptake mechanism constitutes a virulence factor of Candida albicans and may be a target for the development of anti-Candida therapies...
  63. ncbi Natural hybrids from Saccharomyces cerevisiae, Saccharomyces bayanus and Saccharomyces kudriavzevii in wine fermentations
    Sara S González
    Departamento de Biotecnologia, Instituto de Agroquimica y Tecnologia de Alimentos CSIC, Burjassot, Valencia, Spain
    FEMS Yeast Res 6:1221-34. 2006
    ..bayanusxS. cerevisiaexS. kudriavzevii. This is the first time that S. cerevisiaexS. kudriavzevii hybrids have been described which have been involved in wine fermentation...
  64. pmc Genetic analysis of the bipolar pattern of bud site selection in the yeast Saccharomyces cerevisiae
    J E Zahner
    Department of Biology, University of North Carolina, Chapel Hill, 27599, USA
    Mol Cell Biol 16:1857-70. 1996
    ..A bud8 bud9 double mutant also buds almost exclusively from the proximal pole, suggesting that Bud9p is involved in positioning the proximal pole signal rather than being itself a component of this signal...
  65. ncbi Natural history and evolutionary principles of gene duplication in fungi
    Ilan Wapinski
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 449:54-61. 2007
    ..Surprisingly, paralogous modules of genes rarely arise, even after whole-genome duplication. Rather, gene duplication may drive the modularization of functional networks through specialization, thereby disentangling cellular systems...
  66. ncbi Nicotinic acid limitation regulates silencing of Candida adhesins during UTI
    Renee Domergue
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 308:866-70. 2005
    ..The adaptation of C. glabrata to the host, therefore, involves a loss of metabolic capacity and exploitation of the resulting auxotrophy to signal a particular host environment...
  67. ncbi A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage
    Elies C Woudstra
    Mechanisms of Gene Transcription Laboratory, Cancer Research UK, Clare Hall Laboratories, Blanche Lane, South Mimms, Hertfordshire EN6 3LD, UK
    Nature 415:929-33. 2002
  68. ncbi Effects of aneuploidy on cellular physiology and cell division in haploid yeast
    Eduardo M Torres
    Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17 233, 40 Ames Street, Cambridge, MA 02139, USA
    Science 317:916-24. 2007
    ..We conclude that aneuploidy causes not only a proliferative disadvantage but also a set of phenotypes that is independent of the identity of the individual extra chromosomes...
  69. ncbi Mapping pathways and phenotypes by systematic gene overexpression
    Richelle Sopko
    Department of Medical Genetics and Microbiology, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Cell 21:319-30. 2006
    ..Large-scale application of this approach should provide a strategy for identifying target molecules regulated by specific signaling pathways...
  70. pmc An activator/repressor dual system allows tight tetracycline-regulated gene expression in budding yeast
    G Belli
    Departament de Ciencies Mediques Basiques, Facultat de Medicina, Universitat de Lleida, Rovira Roure 44, 25198 Lleida, Spain
    Nucleic Acids Res 26:942-7. 1998
    ..The dual system here described may be useful for the functional analysis of essential genes whose conditional expression can be tightly controlled by tetracyclines...
  71. ncbi brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans
    T H Adams
    Department of Genetics, University of Georgia, Athens 30602
    Cell 54:353-62. 1988
    ..We propose that BRLA is a nucleic acid-binding protein whose expression in vegetative cells is sufficient to induce sporulation through its role in regulating expression of conidiation-specific genes...
  72. ncbi Active genes are tri-methylated at K4 of histone H3
    Helena Santos-Rosa
    Wellcome Trust Cancer Research UK Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QR, UK
    Nature 419:407-11. 2002
    ..These findings establish the concept of methyl status as a determinant for gene activity and thus extend considerably the complexity of histone modifications...
  73. pmc Bidirectional promoters generate pervasive transcription in yeast
    Zhenyu Xu
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 457:1033-7. 2009
  74. pmc Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans
    D W Brown
    Department of Plant Pathology, Texas A and M University, College Station 77843, USA
    Proc Natl Acad Sci U S A 93:1418-22. 1996
    ..A revised system for naming the genes of the ST pathway is presented...
  75. ncbi ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe
    Akihisa Matsuyama
    Chemical Genetics Laboratory, RIKEN, Wako, Saitama 351 0198, Japan
    Nat Biotechnol 24:841-7. 2006
    ..Furthermore, using leptomycin B, an inhibitor of the nuclear export protein Crm1, we identified 285 proteins whose localization is regulated by Crm1...
  76. ncbi Synthetic genetic array analysis in Saccharomyces cerevisiae
    Amy Hin Yan Tong
    Methods Mol Biol 313:171-92. 2006
    ..This array-based approach automates yeast genetic analysis in general and can be easily adapted for a number of different screens, including genetic suppression, plasmid shuffling, dosage lethality, or suppression...
  77. pmc A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters
    Gwenael Badis
    Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada
    Mol Cell 32:878-87. 2008
  78. pmc Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle
    F Verde
    Imperial Cancer Research Fund, London, United Kingdom
    J Cell Biol 131:1529-38. 1995
  79. ncbi Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80
    S Chu
    Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0448, USA
    Mol Cell 1:685-96. 1998
    ..Thus Ndt80 is a pivotal component of a transcriptional cascade programming yeast gametogenesis and may also be a target of meiotic checkpoint control...
  80. ncbi Double-joint PCR: a PCR-based molecular tool for gene manipulations in filamentous fungi
    Jae Hyuk Yu
    Department of Food Microbiology and Toxicology, The University of Wisconsin, Madison, WI 53706, USA
    Fungal Genet Biol 41:973-81. 2004
    ..To stream line the analysis of the transformants a relatively simple procedure for genomic DNA or total RNA isolation achieving approximately 100 samples/person/day is also presented...
  81. ncbi A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase
    C Koch
    Institute of Molecular Pathology, Vienna, Austria
    Science 261:1551-7. 1993
    ..Mbp1 is related to Swi4. Strains deleted for both MBP1 and SWI4 were inviable, demonstrating that transcriptional activation by MBF and SBF has an important role in the transition from G1 to S phase...
  82. ncbi The ZRT2 gene encodes the low affinity zinc transporter in Saccharomyces cerevisiae
    H Zhao
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Minnesota, Duluth, Minnesota 55812, USA
    J Biol Chem 271:23203-10. 1996
    ..Finally, a zrt1zrt2 mutant was viable, indicating the existence of additional zinc uptake pathways...
  83. pmc Inactivation of the Podospora anserina vegetative incompatibility locus het-c, whose product resembles a glycolipid transfer protein, drastically impairs ascospore production
    S Saupe
    Laboratoire de Genetique, UPR 9026 Centre National de la Recherche Scientifique, Universite de Bordeaux II, Talence, France
    Proc Natl Acad Sci U S A 91:5927-31. 1994
    ..The protein encoded by het-c2 is essential in the biology of the fungus and may be involved in cell-wall biosynthesis...
  84. ncbi Yeast life-span extension by calorie restriction is independent of NAD fluctuation
    Rozalyn M Anderson
    Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston MA 02115, USA
    Science 302:2124-6. 2003
    ..Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD+:NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR...
  85. ncbi ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex
    Gaku Mizuguchi
    Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Building 37, Room 6068, Bethesda, MD 20892 4255, USA
    Science 303:343-8. 2004
    ..These findings define a previously unknown role for the adenosine triphosphate-dependent chromatin remodeling machinery...
  86. pmc The yeast ZRT1 gene encodes the zinc transporter protein of a high-affinity uptake system induced by zinc limitation
    H Zhao
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Minnesota, Duluth 55812, USA
    Proc Natl Acad Sci U S A 93:2454-8. 1996
    ..These results suggest that ZRT1 is regulated at the transcriptional level by the intracellular concentration of zinc. ZRT1 is an additional member of a growing family of metal transport proteins...
  87. pmc Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast
    Matthew J Brauer
    Lewis Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 19:352-67. 2008
    ..This concept is useful in interpreting the system-level connections among growth rate, metabolism, stress, and the cell cycle...
  88. pmc The PMT gene family: protein O-glycosylation in Saccharomyces cerevisiae is vital
    M Gentzsch
    Lehrstuhl für Zellbiologie und Pflanzenphysiologie, Universitat Regensburg, Germany
    EMBO J 15:5752-9. 1996
    ..The results show that protein O-glycosylation is essential for cell wall rigidity and cell integrity and that this protein modification, therefore, is vital for Saccharomyces cerevisiae...
  89. pmc Characterization of a glucose-repressed pyruvate kinase (Pyk2p) in Saccharomyces cerevisiae that is catalytically insensitive to fructose-1,6-bisphosphate
    E Boles
    Institut fur Mikrobiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    J Bacteriol 179:2987-93. 1997
    ..The results indicate that the PYK2-encoded pyruvate kinase may be used under conditions of very low glycolytic flux...
  90. pmc Transcriptional responses to fatty acid are coordinated by combinatorial control
    Jennifer J Smith
    Institute for Systems Biology, Seattle, WA 98103 8904, USA
    Mol Syst Biol 3:115. 2007
    ..Together, these data suggest a network mechanism involving dynamic combinatorial control for coordinating transcriptional responses...
  91. pmc Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint
    Orna Dahan
    Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Ramat Aviv 69978, Israel
    Nucleic Acids Res 30:4361-70. 2002
    ..Thus, our results have uncovered an unexpected role for pre-mRNA splicing in the maintenance of the fidelity of chromosome transmission during cell division...
  92. pmc Gene duplication and the evolution of ribosomal protein gene regulation in yeast
    Ilan Wapinski
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:5505-10. 2010
  93. pmc Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1
    A Bender
    Department of Biology, University of Michigan, Ann Arbor 48109
    Proc Natl Acad Sci U S A 86:9976-80. 1989
    ..However, one of the other genes that was isolated by virtue of its ability to suppress cdc24 can also suppress cdc42. This gene, named MSB1, maps between ADE9 and HIS3 on the right arm of chromosome XV...
  94. ncbi The Aspergillus nidulans alcA promoter drives tightly regulated conditional gene expression in Aspergillus fumigatus permitting validation of essential genes in this human pathogen
    Beatriz Romero
    Departamento de Microbiologia y Parasitologia, Facultad de Farmacia, Campus Universitario, Universidad de Alcala, Ctra Madrid Barcelona Km 33, E 28871 Alcala de Henares, Madrid, Spain
    Fungal Genet Biol 40:103-14. 2003
    ..This conditional expression system, the first one described in A. fumigatus, will also be useful for investigating the function of essential genes by altering the threonine/glucose ratio in the growth medium...
  95. pmc Nutritional homeostasis in batch and steady-state culture of yeast
    Alok J Saldanha
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305, USA
    Mol Biol Cell 15:4089-104. 2004
  96. pmc Ancestral polymorphism and adaptive evolution in the trichothecene mycotoxin gene cluster of phytopathogenic Fusarium
    Todd J Ward
    Microbial Genomics and Bioprocessing Research Unit, National Center for Agricultural Utilization Research, U S Department of Agriculture, Agricultural Research Service, 1815 North University Street, Peoria, IL 61604, USA
    Proc Natl Acad Sci U S A 99:9278-83. 2002
    ..Chemotype-specific differences in selective constraint and evidence of adaptive evolution within trichothecene genes are also reported...
  97. ncbi Intergenic transcription is required to repress the Saccharomyces cerevisiae SER3 gene
    Joseph A Martens
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 429:571-4. 2004
    ..This work identifies a previously unknown class of transcriptional regulatory genes...
  98. pmc Additions, losses, and rearrangements on the evolutionary route from a reconstructed ancestor to the modern Saccharomyces cerevisiae genome
    Jonathan L Gordon
    Smurfit Institute of Genetics, Trinity College, Dublin, Ireland
    PLoS Genet 5:e1000485. 2009
    ..Many of the gained genes in S. cerevisiae have functions associated with ethanol production, growth in hypoxic environments, or the uptake of alternative nutrient sources...
  99. pmc Comparative genomics of wild type yeast strains unveils important genome diversity
    Laura Carreto
    Departamento de Biologia and CESAM, Universidade de Aveiro, 3810 193 Aveiro, Portugal
    BMC Genomics 9:524. 2008
    ..This suggests that genome plasticity provides important genetic diversity upon which natural selection mechanisms can operate...
  100. pmc The Aspergillus Genome Database, a curated comparative genomics resource for gene, protein and sequence information for the Aspergillus research community
    Martha B Arnaud
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305 5120, USA
    Nucleic Acids Res 38:D420-7. 2010
    ..All of these data are freely available at We welcome feedback from users and the research community at
  101. pmc Multiple upstream signals converge on the adaptor protein Mst50 in Magnaporthe grisea
    Gyungsoon Park
    Department of Botany and Plant Pathology, Purdue University, West Lafayette, Indiana 47907, USA
    Plant Cell 18:2822-35. 2006
    ..These results indicate that MST50 functions as an adaptor protein interacting with multiple upstream components and plays critical roles in activating the Pmk1 cascade for appressorium formation and plant infection in M. grisea...

Research Grants65

  1. Genetics of Cryptococcus sexual reproduction
    Joseph Heitman; Fiscal Year: 2013
    ..Our studies focus on the role of sexual reproduction in Cryptococcus, leading to genetic diversity and the production of infectious spores. ..
    James E Haber; Fiscal Year: 2013
    ..Identification of the phospho-threonine target in the region around the DSB will be carried out, both by characterization of the FHA domain and by analysis of DSB-dependent proteins that associate with the FHA domain. ..
  3. SWI/SNF complex loss facilitates gene silencing during NSCLC development
    Bernard E Weissman; Fiscal Year: 2010
    ..abstract_text> ..
  4. Structure, function, and evolution of the Cryptococcus MAT locus
    Joseph Heitman; Fiscal Year: 2013
    ..These studies will expand understanding of this unique genomic region and its roles in virulence, and serve as a paradigm for gene cluster and sex chromosome evolution and function. ..
  5. Molecular and Cellular Phenotype of Aging and iPS Cells
    JOSEPH C contact WU; Fiscal Year: 2010
  6. Accessing Natural Products from Silent Biosynthetic Pathways
    ROBERT HENRY CICHEWICZ; Fiscal Year: 2012
    ..Our group will test a new methodology based on epigenetic induction for targeting the activation of fungal genes involved in natural product biosynthesis...
  7. Sequencing yeast lines to measure rates of neutral and deleterious mutations
    Mark L Siegal; Fiscal Year: 2013
  8. Functional Sir2-RNA Interactions
    JEFFREY SCOTT SMITH; Fiscal Year: 2013
    ..These exploratory and developmental studies will define the basic mechanism and specificity of the functional Sir2-RNA interaction and set us up for more detailed functional and structure-function studies in the future. ..
  9. Phenotypic Plasticity and Sexual Reproduction in Candida tropicalis Pathogenesis
    Allison M Porman; Fiscal Year: 2013
    ..Understanding how the different aspects of C. tropicalis biology affect its virulence will enhance our knowledge of how this species is so well suited to grow in the mammalian host both as a commensal and a pathogen. ..
  10. Resveratrol as an adjunct to resuscitation fluid following hemorrhage injury
    RAGHAVAN PILLAI RAJU; Fiscal Year: 2013
    ..abstract_text> ..
  11. Interrogation of functional aspects of transcription at heterochromatic loci
    KEITH MICHAEL CONNOLLY; Fiscal Year: 2013
    ..Taken together, these aims will seek to uncover previously unappreciated aspects of transcription at heterochromatic loci, and will provide an ideal opportunity for training in a new field of biological study. ..
  12. Mechanism of Yeast Transcriptional Regulators
    Alexander D Johnson; Fiscal Year: 2013
    ..Plasticity in transcriptional circuitry is well documented, and a deeper understanding of it will provide insights into recognizing and perhaps treating cases where it leads to aberrant physiologies. ..
    Brian Wickes; Fiscal Year: 2002
    ..neoformans. ..
    Richard Weiss; Fiscal Year: 1980
    ..Experiments will be performed to obtain mutants with a defect in the mt minus mating structure. An analysis of these mutants should provide information on mating structure function and on the mechanism of cell fusion...
  15. A link between mating pheromone sensing and virulence of Cryptococcus neoformans
    Kirsten Nielsen; Fiscal Year: 2009
    Ronald Davis; Fiscal Year: 1999
    ..This genomic sequencing approach is essentially a large-scale method of gene discovery which will quickly and economically provide key research tools to the entire Candida albicans community. ..
    GEORGE SPRAGUE; Fiscal Year: 1991
  18. Twenty Second Fungal Genetics Conference, Asilomar, CA
    Marc Orbach; Fiscal Year: 2003
    ..Funds are requested to help defray the travel and participation costs of students, postdoctoral researchers and some invited speakers and will be distributed on a need basis. ..
    Eduardo Orias; Fiscal Year: 1990
    JANET KURJAN; Fiscal Year: 1999
    ..Because cell wall structure in other fungi is similar to yeast, investigation of the mechanism of cell wall biogenesis in S. cerevisiae may lead to the development of therapeutic agents against medically important fungi. ..
    Andrew Vershon; Fiscal Year: 2001
    ..The analysis of recombinational-repair proteins in simpler and more tractable organisms, like yeast, will therefore provide invaluable insights into several fundamental and important cellular processes. ..
    CHARLES SIH; Fiscal Year: 2001
    ..2) HYBRID AROMATIC POLYKETIDES MADE WITH BACTERIAL AND/OR FUNGAL GENES. (a) Analyze the mechanism of polyketide cyclases by studying the properties of hybrid sets of PKS genes ..
    Rui Ming Xu; Fiscal Year: 2003
    ..Results from these experiments will lead to comprehensive models about how distinct chromatin domains are established and propagated. ..
    Andrew Vershon; Fiscal Year: 2005
    ..The information we learn about the interactions between these different classes of proteins will be relevant to more complex systems in higher eukaryotes and will provide insight on how these proteins function to regulate development. ..
    Marjorie Crandall; Fiscal Year: 1980
    ..Cell surface matrix will also be investigated in parallel studies with the yeast Candida albicans in an attempt to identify cell surface factors involved in yeast flocculation, adherence to animal cells and antigenicity. ..
    Charles Young; Fiscal Year: 2003
    ..In addition, the kinase activity of DNA-PK will be measured to see if it is inhibited by E4orf6. ..
    JEANNE HIRSCH; Fiscal Year: 2004
    ..abstract_text> ..
  28. Mechanisms of 3'UTR Control: Yeast PUF Proteins
    Aaron Goldstrohm; Fiscal Year: 2004
    ..Finally, an in vitro mRNA turnover assay will used to further dissect the mechanism of Puf5p repression. ..
    JEF BOEKE; Fiscal Year: 2005
    ..We will use the tools of molecular genetics, biochemistry and structural biology to carry out a comprehensive analysis of the molecular mechanisms involved in silencing. ..
    RICHARD KOSTRIKEN; Fiscal Year: 2000
    ..The results of this study will test the hypothesis that switching (and the directionality of switching) depends upon specific pairing of the relevant regions. ..
    SHUNG CHANG JONG; Fiscal Year: 2000
    Robert Schlegel; Fiscal Year: 2003
    ..abstract_text> ..
    LISA KLIG; Fiscal Year: 1992
    ..banks of human cDNA; 2) polymerase chain reaction using human mRNA as template and conserved regions of the fungal genes as primers, and; 3) purification of the human protein and subsequent generation of sequence information to ..
  34. SWI/SNF-related complex in osteoblast differentiation
    Elizabeth Moran; Fiscal Year: 2009
    ..The proposed systems will provide important clinical data, relevant to broad public health problems, such as osteoporosis and inflammatory diseases, as well as to cancer. ..
  35. C.elegans as a model system forC.neoformans pathogenesis
    Eleftherios Mylonakis; Fiscal Year: 2007
    ..Because C. neoformanshas similarities with other pathogenic yeasts, we expect that our findings will facilitate the study of fungus/host interaction in general. ..
  36. Fungal genes required for multiple host pathogenesis
    Andrew Diener; Fiscal Year: 2004
    ..the wax moth caterpillar Galleria mellonella and the plant Arabidopsis thaliana, will be used to identify fungal genes necessary for the pathogenesis of an animal, a plant or both hosts...
    Vivian MacKay; Fiscal Year: 1980
    ..c. The location of the primary receptors for the mating hormones. d. The identification of the TUP1 gene product ( alpha tup1 strains exhibit partial hormone response constitutively)...
    JENNIFER LODGE; Fiscal Year: 2003
    ..neoformans is an excellent model for other opportunistic fungal pathogens. To identify fungal genes that are essential for pathogenesis, "signature-tagged" mutagenesis, a novel screen which has been highly ..
    Andrew Vershon; Fiscal Year: 2003
    ..The mechanism by which Sum1 and Hst1 repress transcription will be investigated. Additionally, the regulation of Sum1 and Hst1 activity by the meiotic regulatory pathway will be examined. ..
  40. Molecular Genetics of Aspergillosis
    Gregory May; Fiscal Year: 2005
    ..Using SSH and a murine model of IPA, we will identify those fungal genes that are highly expressed during invasive growth. We will use the A...
    Mark Rose; Fiscal Year: 2001
    ..By these means, the digital deconvolution microscope will provide outstanding research and educational opportunities on one of the most powerful optical microscopes available for use in the life sciences. ..
  42. Ash1p Mediated Transcriptional Repression
    LENNY CARRUTHERS; Fiscal Year: 2003
    ..And aim 3 will examine the chromatin structure of the HO locus in the presence of Ash1p. ..
    Ira Herskowitz; Fiscal Year: 1980
    Fred Heffron; Fiscal Year: 1991
    ..The long term goal of this research is to identify and characterize the important nucleases from this eukaryotic organism...
    Rodney Rothstein; Fiscal Year: 1993
    ..The overall goal of this project is to facilitate the ordering of cloned genomic fragments for the eventual complete analysis of any large genome(including physical mapping and sequencing)...
    Rolf Sternglanz; Fiscal Year: 2006
    ..Progress in these areas will shed light on chromosome structure and function in the eukaryotic nucleus, not only in yeast but also in mammalian cells. ..
    David Beach; Fiscal Year: 1992
    ..4) Search for substances of the ran1+ protein kinase. 5) Since ran1+ is involved not only in meiotic control but more broadly in growth control in S. pombe, we will seek homologues of this gene in the cells of higher organisms...
  48. Transcriptional Silencing Near tRNA Genes
    DAVID ENGELKE; Fiscal Year: 2004
    ..The aims of this project are to investigate the mechanism of conditional tgm silencing in yeast. ..
    JENNIFER LODGE; Fiscal Year: 2001
    ..To identify fungal genes that are essential for pathogenesis...
  50. Role of Calcineurin in Fungal Virulence
    Joseph Heitman; Fiscal Year: 2009
    ..Importantly, this pathway can be targeted for therapeutic intervention using non-immunosuppressive calcineurin inhibitors that retain antifungal activity and synergistic drug combinations that we have discovered. ..
  51. Genetics of mating and fruiting in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2010
    ..neoformans and C. gattii applicable to development of treatment approaches, diagnostics, or environmental interventions to reduce exposure to infectious spores. ..
  52. GPCR signaling cascades in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  53. Genetic analysis of Cryptococcus neoformans virulence
    Joseph Heitman; Fiscal Year: 2009
    ..These studies will enable a genome-wide definition of the gene set contributing to virulence of this common human fungal pathogen. ..
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  55. Switching and Candida Pathogenesis-A Molecular Analysis
    David Soll; Fiscal Year: 2005
    ..The first three aims have been formulated so that they provide several independent starting points for a reverse genetic approach for elucidating switch loci and the switching mechanism. ..
    David Soll; Fiscal Year: 2006
    ..abstract_text> ..
  57. Light-regulated genes affecting the pathogen potential of Cryptococcus neoformans
    Alexander Idnurm; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
    James Haber; Fiscal Year: 2006
    ..abstract_text> ..
  59. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  60. Characterization of a large protein interaction network
    Andreas Wagner; Fiscal Year: 2005
    ..The proposed work will put this speculation to an end for a key genetic network, some of whose conserved components are also involved in the etiology of human disease. ..
  61. Detection and Understanding of Expression Differentiatio
    Lei Li; Fiscal Year: 2009
    ..To serve the scientific mission, we develop and integrate statistical and computational methodologies. Our research will benefit the society by new understanding of aging. ..
  62. Targeted 2nd generation sequencing in phenotyped Framingham & PGP populations.
    George M Church; Fiscal Year: 2010
    ..It will eventually also enable health providers to learn the genetic variations of their patients very inexpensively and thus help refine and improve their medical care. ..
  63. Cellular & Molecular Fungal Biology 2008 Gordon Research Conference
    Nancy Keller; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  64. Gordon Conf. on Cellular and Molecular Fungal Biology
    James Kronstad; Fiscal Year: 2004
    ..In summary, the conference provides a unique opportunity to examine the breadth of fungal biology in a small meeting format that encourages in-depth discussion among the attendees. ..