fungal genome

Summary

Summary: The complete gene complement contained in a set of chromosomes in a fungus.

Top Publications

  1. pmc Genomic expression programs in the response of yeast cells to environmental changes
    A P Gasch
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5428, USA
    Mol Biol Cell 11:4241-57. 2000
  2. ncbi Functional profiling of the Saccharomyces cerevisiae genome
    Guri Giaever
    Stanford Genome Technology Center, Stanford University, Palo Alto, California 94304, USA
    Nature 418:387-91. 2002
  3. ncbi Global analysis of protein expression in yeast
    Sina Ghaemmaghami
    Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94143 2240, USA
    Nature 425:737-41. 2003
  4. ncbi Global analysis of protein localization in budding yeast
    Won Ki Huh
    Howard Hughes Medical Institute, University of California San Francisco, Department of Biochemistry and Biophysics, 600 16th Street, San Francisco, California 94143 2240, USA
    Nature 425:686-91. 2003
  5. ncbi Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
    Jörg Kämper
    Department of Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Nature 444:97-101. 2006
  6. pmc Population genomics of domestic and wild yeasts
    Gianni Liti
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Nature 458:337-41. 2009
  7. pmc The transcriptional landscape of the yeast genome defined by RNA sequencing
    Ugrappa Nagalakshmi
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Science 320:1344-9. 2008
  8. ncbi The genome sequence of the rice blast fungus Magnaporthe grisea
    Ralph A Dean
    Center for Integrated Fungal Research, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nature 434:980-6. 2005
  9. pmc Evolution of pathogenicity and sexual reproduction in eight Candida genomes
    Geraldine Butler
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Nature 459:657-62. 2009
  10. ncbi The genome sequence of the filamentous fungus Neurospora crassa
    James E Galagan
    Whitehead Institute Center for Genome Research, 320 Charles Street, Cambridge, Massachusetts 02141, USA
    Nature 422:859-68. 2003

Research Grants

Detail Information

Publications251 found, 100 shown here

  1. pmc Genomic expression programs in the response of yeast cells to environmental changes
    A P Gasch
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305 5428, USA
    Mol Biol Cell 11:4241-57. 2000
    ..Physiological themes in the genomic responses to specific environmental stresses provided insights into the effects of those stresses on the cell...
  2. ncbi Functional profiling of the Saccharomyces cerevisiae genome
    Guri Giaever
    Stanford Genome Technology Center, Stanford University, Palo Alto, California 94304, USA
    Nature 418:387-91. 2002
    ..Our results validate the yeast gene-deletion collection as a valuable resource for functional genomics...
  3. ncbi Global analysis of protein expression in yeast
    Sina Ghaemmaghami
    Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California 94143 2240, USA
    Nature 425:737-41. 2003
    ..Many of these molecules, including essential proteins and most transcription factors, are present at levels that are not readily detectable by other proteomic techniques nor predictable by mRNA levels or codon bias measurements...
  4. ncbi Global analysis of protein localization in budding yeast
    Won Ki Huh
    Howard Hughes Medical Institute, University of California San Francisco, Department of Biochemistry and Biophysics, 600 16th Street, San Francisco, California 94143 2240, USA
    Nature 425:686-91. 2003
    ....
  5. ncbi Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
    Jörg Kämper
    Department of Organismic Interactions, Max Planck Institute for Terrestrial Microbiology, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Nature 444:97-101. 2006
    ..Genomic analysis is, similarly, likely to open up new avenues for the discovery of virulence determinants in other pathogens...
  6. pmc Population genomics of domestic and wild yeasts
    Gianni Liti
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Nature 458:337-41. 2009
    ....
  7. pmc The transcriptional landscape of the yeast genome defined by RNA sequencing
    Ugrappa Nagalakshmi
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Science 320:1344-9. 2008
    ..We also found unexpected 3'-end heterogeneity and the presence of many overlapping genes. These results indicate that the yeast transcriptome is more complex than previously appreciated...
  8. ncbi The genome sequence of the rice blast fungus Magnaporthe grisea
    Ralph A Dean
    Center for Integrated Fungal Research, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nature 434:980-6. 2005
    ..The M. grisea genome has been subject to invasion and proliferation of active transposable elements, reflecting the clonal nature of this fungus imposed by widespread rice cultivation...
  9. pmc Evolution of pathogenicity and sexual reproduction in eight Candida genomes
    Geraldine Butler
    UCD School of Biomolecular and Biomedical Science, Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Nature 459:657-62. 2009
    ..Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes...
  10. ncbi The genome sequence of the filamentous fungus Neurospora crassa
    James E Galagan
    Whitehead Institute Center for Genome Research, 320 Charles Street, Cambridge, Massachusetts 02141, USA
    Nature 422:859-68. 2003
    ..Genome analysis suggests that RIP has had a profound impact on genome evolution, greatly slowing the creation of new genes through genomic duplication and resulting in a genome with an unusually low proportion of closely related genes...
  11. ncbi The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization
    Christina A Cuomo
    Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142, USA
    Science 317:1400-2. 2007
    ..These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts...
  12. ncbi Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae
    James E Galagan
    The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, Massachusetts 02142, USA
    Nature 438:1105-15. 2005
    ..These results enhance our understanding of these widely studied fungi as well as provide new insight into eukaryotic genome evolution and gene regulation...
  13. ncbi Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
    William C Nierman
    The Institute for Genomic Research, Rockville, Maryland 20850, USA
    Nature 438:1151-6. 2005
    ..The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus...
  14. ncbi The genome sequence of Schizosaccharomyces pombe
    V Wood
    The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nature 415:871-80. 2002
    ....
  15. ncbi The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis
    F Martin
    UMR 1136, INRA Nancy Université, Interactions Arbres Microorganismes, INRA Nancy, 54280 Champenoux, France
    Nature 452:88-92. 2008
    ....
  16. ncbi Systematic genetic analysis with ordered arrays of yeast deletion mutants
    A H Tong
    Banting and Best Department of Medical Research, University of Toronto, Toronto ON, Canada M5G 1L6
    Science 294:2364-8. 2001
    ..Systematic application of this approach should produce a global map of gene function...
  17. ncbi Dynamics of replication-independent histone turnover in budding yeast
    Michael F Dion
    Faculty of Arts and Sciences, Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
    Science 315:1405-8. 2007
    ..In addition, rapid histone turnover is found at known chromatin boundary elements. These results suggest that rapid histone turnover serves to functionally separate chromatin domains and prevent spread of histone states...
  18. ncbi Genome sequencing and analysis of the biomass-degrading fungus Trichoderma reesei (syn. Hypocrea jecorina)
    Diego Martinez
    Los Alamos National Laboratory Joint Genome Institute, PO Box 1663, Los Alamos, New Mexico 87545, USA
    Nat Biotechnol 26:553-60. 2008
    ..Our analysis, coupled with the genome sequence data, provides a roadmap for constructing enhanced T. reesei strains for industrial applications such as biofuel production...
  19. pmc Intragenic tandem repeats generate functional variability
    Kevin J Verstrepen
    Whitehead Institute for Biomedical Research Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 37:986-90. 2005
    ..We propose that variation in intragenic repeat number provides the functional diversity of cell surface antigens that, in fungi and other pathogens, allows rapid adaptation to the environment and elusion of the host immune system...
  20. ncbi Genome sequence of the lignocellulose degrading fungus Phanerochaete chrysosporium strain RP78
    Diego Martinez
    US DOE Joint Genome Institute, Walnut Creek, California 94598, USA
    Nat Biotechnol 22:695-700. 2004
    ..This genome provides a high quality draft sequence of a basidiomycete, a major fungal phylum that includes important plant and animal pathogens...
  21. pmc Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism
    Katherine A Borkovich
    Department of Plant Pathology, University of California, Riverside, California 92521, USA
    Microbiol Mol Biol Rev 68:1-108. 2004
    ..The group of unshared genes includes potential new targets for antifungals as well as loci implicated in human and plant physiology and disease...
  22. pmc Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus
    Natalie D Fedorova
    The J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000046. 2008
    ..The role of duplication in the origin of lineage-specific genes is further underlined by the discovery of genomic islands that seem to function as designated "gene dumps" and, perhaps, simultaneously, as "gene factories"...
  23. pmc Genetic interactions between polymorphisms that affect gene expression in yeast
    Rachel B Brem
    Program in Computational Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, M2 B876, Seattle, Washington 98109, USA
    Nature 436:701-3. 2005
    ..Our results indicate that genetic interactions are widespread in the genetics of transcript levels, and that many QTLs will be missed by single-locus tests but can be detected by two-stage tests that allow for interactions...
  24. pmc The chemical genomic portrait of yeast: uncovering a phenotype for all genes
    Maureen E Hillenmeyer
    Stanford Genome Technology Center, Stanford University, Palo Alto, CA 94304, USA
    Science 320:362-5. 2008
    ..We found that 97% of gene deletions exhibited a measurable growth phenotype, suggesting that nearly all genes are essential for optimal growth in at least one condition...
  25. ncbi Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization
    Jason M Casolari
    Department of Systems Biology, Harvard Medical School and Department of Cancer Biology, The Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cell 117:427-39. 2004
    ..Taken together, these results indicate that the organization of the genome is coupled via transcriptional state to the nuclear transport machinery...
  26. ncbi Genetic dissection of transcriptional regulation in budding yeast
    Rachel B Brem
    Fred Hutchinson Cancer Research Center FHCRC, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109, USA and Howard Hughes Medical Institute
    Science 296:752-5. 2002
    ..We found eight such trans-acting loci, each affecting the expression of a group of 7 to 94 genes of related function...
  27. pmc The genome of Nectria haematococca: contribution of supernumerary chromosomes to gene expansion
    Jeffrey J Coleman
    Department of Plant Sciences, University of Arizona, Tucson, Arizona, United States of America
    PLoS Genet 5:e1000618. 2009
    ..Furthermore, the presence of unique genes on supernumerary chromosomes might account for individual isolates having different environmental niches...
  28. pmc Dandruff-associated Malassezia genomes reveal convergent and divergent virulence traits shared with plant and human fungal pathogens
    Jun Xu
    Procter and Gamble Co, Miami Valley Innovation Center, Cincinnati, OH 45253 8707, USA
    Proc Natl Acad Sci U S A 104:18730-5. 2007
    ..The M. globosa genome sequence also revealed the presence of mating-type genes, providing an indication that Malassezia may be capable of sex...
  29. pmc High-resolution mapping of meiotic crossovers and non-crossovers in yeast
    Eugenio Mancera
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 454:479-85. 2008
    ..In addition, because non-crossover hotspots create holes of reduced linkage within haplotype blocks, our results stress the need to incorporate non-crossovers into genetic linkage analysis...
  30. ncbi Genome sequencing and analysis of Aspergillus oryzae
    Masayuki Machida
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Higashi 1 1 1, Tsukuba, Ibaraki 305 8566, Japan
    Nature 438:1157-61. 2005
    ..Specific expansion of genes for secretory hydrolytic enzymes, amino acid metabolism and amino acid/sugar uptake transporters supports the idea that A. oryzae is an ideal microorganism for fermentation...
  31. ncbi Genomics of the fungal kingdom: insights into eukaryotic biology
    James E Galagan
    The Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts 02141, USA
    Genome Res 15:1620-31. 2005
    ..Since the sequencing of the first fungus in 1996, the number of available fungal genome sequences has increased by an order of magnitude...
  32. ncbi Genome-scale approaches to resolving incongruence in molecular phylogenies
    Antonis Rokas
    Howard Hughes Medical Institute, Laboratory of Molecular Biology, R M Bock Laboratories, University of Wisconsin Madison, 1525 Linden Drive, Madison, Wisconsin 53706, USA
    Nature 425:798-804. 2003
    ..These results have important implications for resolving branches of the tree of life...
  33. pmc The genome sequence of the model ascomycete fungus Podospora anserina
    Eric Espagne
    Univ Paris Sud, Institut de Genetique et Microbiologie, UMR8621, 91405 Orsay Cedex, France
    Genome Biol 9:R77. 2008
    ..The dung-inhabiting ascomycete fungus Podospora anserina is a model used to study various aspects of eukaryotic and fungal biology, such as ageing, prions and sexual development...
  34. pmc Genomic analyses of the microsporidian Nosema ceranae, an emergent pathogen of honey bees
    R Scott Cornman
    USDA ARS Bee Research Lab, Beltsville, Maryland, United States of America
    PLoS Pathog 5:e1000466. 2009
    ..cuniculi. These comparisons provide insight into the architecture, regulation, and evolution of microsporidian genomes, and will drive investigations into honey bee-Nosema interactions...
  35. pmc GOtcha: a new method for prediction of protein function assessed by the annotation of seven genomes
    David M A Martin
    Post Genomics and Molecular Interactions Centre, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    BMC Bioinformatics 5:178. 2004
    ..GOtcha predicts GO term associations with term-specific probability (P-score) measures of confidence. Term-specific probabilities are a novel feature of GOtcha and allow the identification of conflicts or uncertainty in annotation...
  36. pmc Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56
    Robert Driscoll
    Wellcome Trust and Cancer Research U K Gurdon Institute and the Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Science 315:649-52. 2007
    ..These data establish Rtt109p as a member of a new class of histone acetyltransferases and show that its actions are critical for cell survival in the presence of DNA damage during S phase...
  37. ncbi Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery
    Terry Roemer
    Elitra Canada, Montreal, Quebec, Canada, H2X 3Y8
    Mol Microbiol 50:167-81. 2003
    ..albicans essential gene set, and their respective conditional mutant strains may be directly used as sensitive whole-cell assays for drug screening...
  38. ncbi Genome evolution in yeasts
    Bernard Dujon
    Unité de Génétique Moléculaire des Levures, URA 2171 CNRS and UFR 927 Université Pierre et Marie Curie
    Nature 430:35-44. 2004
    ....
  39. pmc Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a whole-genome duplication
    Li Jun Ma
    The Broad Institute of MIT and Harvard, Cambridge, MA, USA
    PLoS Genet 5:e1000549. 2009
    ..Expanded families of cell-wall synthesis enzymes, essential for fungal cell integrity but absent in mammalian hosts, reveal potential targets for novel and R. oryzae-specific diagnostic and therapeutic treatments...
  40. pmc Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation
    Antonis Kirmizis
    Gurdon Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QN, UK
    Nature 449:928-32. 2007
    ..Thus, the inability of Spp1 to recognize H3 methylated at R2 prevents Set1 from trimethylating H3K4. These results provide the first mechanistic insight into the function of arginine methylation on chromatin...
  41. ncbi Specificity and stability in topology of protein networks
    Sergei Maslov
    Department of Physics, Brookhaven National Laboratory, Upton, NY 11973, USA
    Science 296:910-3. 2002
    ..This effect decreases the likelihood of cross talk between different functional modules of the cell and increases the overall robustness of a network by localizing effects of deleterious perturbations...
  42. pmc The parasexual cycle in Candida albicans provides an alternative pathway to meiosis for the formation of recombinant strains
    Anja Forche
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, United States of America
    PLoS Biol 6:e110. 2008
    ..albicans. We discuss, in light of the long association of C. albicans with warm-blooded animals, the potential advantages of a parasexual cycle over a conventional sexual cycle...
  43. pmc The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species
    Kevin P Byrne
    Department of Genetics, Smurfit Institute, University of Dublin, Trinity College, Dublin 2, Ireland
    Genome Res 15:1456-61. 2005
    ..cerevisiae (551, including 22 previously unidentified), Saccharomyces castellii (599), and Candida glabrata (404)...
  44. pmc Comparative genomics of protoploid Saccharomycetaceae
    Jean Luc Souciet
    Universite de Strasbourg, CNRS UMR, France
    Genome Res 19:1696-709. 2009
    ..Ancient, conserved paralogs as well as novel, lineage-specific paralogs were identified...
  45. ncbi Exploring the metabolic and genetic control of gene expression on a genomic scale
    J L DeRisi
    Department of Biochemistry, Stanford University School of Medicine, Howard Hughes Medical Institute, Stanford, CA 94305 5428, USA
    Science 278:680-6. 1997
    ..These results demonstrate the feasibility and utility of this approach to genomewide exploration of gene expression patterns...
  46. ncbi Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum
    Marco A van den Berg
    DSM Anti Infectives, PO Box 425, 2600 AK Delft, The Netherlands
    Nat Biotechnol 26:1161-8. 2008
    ....
  47. pmc Patterns of intron gain and loss in fungi
    Cydney B Nielsen
    Department of Biology, Massachusetts Institute of Technology Cambridge, Massachusetts, USA
    PLoS Biol 2:e422. 2004
    ..Contrary to standard models, we find no increased frequency of intron loss toward the 3' ends of genes. Thus, recent intron dynamics do not support a model whereby 5' intron positional bias is generated solely by 3'-biased intron loss...
  48. ncbi The origins of multicellularity: a multi-taxon genome initiative
    Inaki Ruiz-Trillo
    Canadian Institute for Advanced Research, Program in Evolutionary Biology, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Trends Genet 23:113-8. 2007
    ..Here, we introduce this initiative and the biological questions that underpin it, summarize the rationale guiding the choice of organisms and discuss the anticipated benefits to the broader scientific community...
  49. ncbi Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast
    Feng He
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Mol Cell 12:1439-52. 2003
    ....
  50. ncbi Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity
    Huck Hui Ng
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 11:709-19. 2003
    ....
  51. ncbi Molecular evidence for an ancient duplication of the entire yeast genome
    K H Wolfe
    Department of Genetics, University of Dublin, Trinity College, Ireland
    Nature 387:708-13. 1997
    ..Tetraploidy may have facilitated the evolution of anaerobic fermentation in Saccharomyces...
  52. ncbi The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae
    F Foury
    Unite de Biochimie Physiologique, Louvain la Neuve, Belgium
    FEBS Lett 440:325-31. 1998
    ..Our data suggest that shuffling of mobile elements plays an important role in the remodelling of the yeast mitochondrial genome...
  53. pmc Cell-to-cell stochastic variation in gene expression is a complex genetic trait
    Juliet Ansel
    Universite de Lyon, Lyon, France
    PLoS Genet 4:e1000049. 2008
    ..The complex genetic architecture of noise buffering couples genetic to non-genetic robustness and provides a molecular basis to the probabilistic nature of complex traits...
  54. ncbi Dissecting the regulatory circuitry of a eukaryotic genome
    F C Holstege
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
    Cell 95:717-28. 1998
    ....
  55. pmc Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans
    Brice Enjalbert
    Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom
    Mol Biol Cell 17:1018-32. 2006
    ..albicans has diverged from corresponding networks in model yeasts and that the C. albicans SAPK pathway functions in parallel with other pathways to regulate the core transcriptional response to stress...
  56. ncbi Proteome survey reveals modularity of the yeast cell machinery
    Anne Claude Gavin
    Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 440:631-6. 2006
    ..This study provides the largest collection of physically determined eukaryotic cellular machines so far and a platform for biological data integration and modelling...
  57. ncbi Genome-wide patterns of histone modifications in yeast
    Catherine B Millar
    Department of Biological Chemistry, Geffen School of Medicine and the Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
    Nat Rev Mol Cell Biol 7:657-66. 2006
    ..Such patterns might be important for the regulation of heterochromatin-mediated silencing, chromosome segregation, DNA replication and gene expression...
  58. ncbi ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome
    C Liang
    Cold Spring Harbor Laboratory, New York 11724, USA
    Cell 81:667-76. 1995
    ..We suggest that ORC and Cdc6p form a prereplication complex at individual replicators and therefore cooperate to determine the frequency of initiation of DNA replication in the genome...
  59. ncbi Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
    Herman J Pel
    DSM Food Specialties, PO Box 1, 2600 MA Delft, The Netherlands
    Nat Biotechnol 25:221-31. 2007
    ..niger. Noteworthy is the large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors, and the presence of putative gene clusters for fumonisin and ochratoxin A synthesis...
  60. pmc A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome
    Travis N Mavrich
    Center for Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genome Res 18:1073-83. 2008
    ..3' NFRs may be important for transcription termination and anti-sense initiation. We present a high-resolution genome-wide map of TFIIB locations that implicates 3' NFRs in gene looping...
  61. ncbi Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae
    Manolis Kellis
    The Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 428:617-24. 2004
    ..Strikingly, 95% of cases of accelerated evolution involve only one member of a gene pair, providing strong support for a specific model of evolution, and allowing us to distinguish ancestral and derived functions...
  62. pmc Mechanistic plasticity of sexual reproduction and meiosis in the Candida pathogenic species complex
    Jennifer L Reedy
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Biol 19:891-9. 2009
    ....
  63. pmc The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans
    Brendan J Loftus
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 307:1321-4. 2005
    ..neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes...
  64. ncbi The yeast genome project: what did we learn?
    B Dujon
    Unité de Génétique Moléculaire des Levures URA 1149 CNRS, Paris, France
    Trends Genet 12:263-70. 1996
    ..Offering the possibility of large-scale reverse genetics, yeast will be a powerful model for post-sequencing studies. But geneticists are now faced with the difficulty of asking novel questions...
  65. pmc Singular value decomposition for genome-wide expression data processing and modeling
    O Alter
    Departments of Genetics and Biochemistry, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 97:10101-6. 2000
    ....
  66. pmc A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations
    Meng Er Huang
    Ludwig Institute for Cancer Research, Department of Medicine and Cancer Center, University of California at San Diego, School of Medicine, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 100:11529-34. 2003
    ..Study of such genes should provide useful clues in identification of human genes potentially involved in cancer predisposition and in understanding their mechanisms of action...
  67. pmc A genomic study of the bipolar bud site selection pattern in Saccharomyces cerevisiae
    L Ni
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520 8103, USA
    Mol Biol Cell 12:2147-70. 2001
    ..Genome-wide screens of defined collections of mutants hold significant promise for dissecting many biological processes in yeast...
  68. ncbi Candida Albicans: a molecular revolution built on lessons from budding yeast
    Judith Berman
    Department of Genetics, Cell Biology and Development, 6 160 Jackson Hall, 321 Church Street SE, Minneapolis, Minnesota 55455, USA
    Nat Rev Genet 3:918-30. 2002
    ..They also reveal the extent of similarities and differences between C. albicans and its benign relative, Saccharomyces cerevisiae...
  69. pmc Molecular characterization of a chromosomal rearrangement involved in the adaptive evolution of yeast strains
    José E Pérez-Ortín
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, Spain
    Genome Res 12:1533-9. 2002
    ..This is the first time that a gross chromosomal rearrangement is shown to be involved in the adaptive evolution of Saccharomyces cerevisiae...
  70. ncbi Natural history and evolutionary principles of gene duplication in fungi
    Ilan Wapinski
    Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 449:54-61. 2007
    ..Surprisingly, paralogous modules of genes rarely arise, even after whole-genome duplication. Rather, gene duplication may drive the modularization of functional networks through specialization, thereby disentangling cellular systems...
  71. ncbi A high-resolution atlas of nucleosome occupancy in yeast
    William Lee
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Nat Genet 39:1235-44. 2007
    ..A quantitative model of nucleosome occupancy indicates that DNA structural features may account for much of the global nucleosome occupancy...
  72. ncbi Population genomic analysis of outcrossing and recombination in yeast
    Douglas M Ruderfer
    Lewis Sigler Institute for Integrative Genomics and Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nat Genet 38:1077-81. 2006
    ..Our results provide the initial foundation for population studies of association between genotype and phenotype in S. cerevisiae...
  73. ncbi Evidence for sexuality in the opportunistic fungal pathogen Aspergillus fumigatus
    Mathieu Paoletti
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    Curr Biol 15:1242-8. 2005
    ..The possible presence of a sexual cycle is highly significant for the population biology and disease management of the species...
  74. pmc Global transcriptome and deletome profiles of yeast exposed to transition metals
    Yong Hwan Jin
    Nicholas School of the Environment and Earth Sciences, Duke University, Durham, North Carolina, United States of America
    PLoS Genet 4:e1000053. 2008
    ....
  75. ncbi Correlated asymmetry of sequence and functional divergence between duplicate proteins of Saccharomyces cerevisiae
    Seong Ho Kim
    School of Biology, Georgia Institute of Technology, USA
    Mol Biol Evol 23:1068-75. 2006
    ..In particular, we detect signs of purifying selection on the more slowly evolving duplicate...
  76. pmc Genome-wide analysis of mRNA translation profiles in Saccharomyces cerevisiae
    Yoav Arava
    Department of Biochemistry, Stanford University, Stanford, CA 94305 5307, USA
    Proc Natl Acad Sci U S A 100:3889-94. 2003
    ..Global analysis revealed an unexpected correlation: Ribosome density decreases with increasing ORF length. Models to account for this surprising observation are discussed...
  77. pmc Bidirectional promoters generate pervasive transcription in yeast
    Zhenyu Xu
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 457:1033-7. 2009
    ....
  78. ncbi Getting started with yeast
    Fred Sherman
    Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York 14642, USA
    Methods Enzymol 350:3-41. 2002
  79. pmc A genome-wide view of the spectrum of spontaneous mutations in yeast
    Michael Lynch
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Proc Natl Acad Sci U S A 105:9272-7. 2008
    ....
  80. pmc High-density yeast-tiling array reveals previously undiscovered introns and extensive regulation of meiotic splicing
    Kara Juneau
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 104:1522-7. 2007
    ..This robust methodology can be used to explore environmentally distinct splicing responses and should be readily adaptable to the study of other organisms, including humans...
  81. pmc The COG database: a tool for genome-scale analysis of protein functions and evolution
    R L Tatusov
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    Nucleic Acids Res 28:33-6. 2000
    ..The COG database is accompanied by the COGNITOR program that is used to fit new proteins into the COGs and can be applied to functional and phylogenetic annotation of newly sequenced genomes...
  82. ncbi Phylogenomics: the beginning of incongruence?
    Olivier Jeffroy
    Canadian Institute for Advanced Research, Centre Robert Cedergren, Departement de Biochimie, Universite de Montreal, Succursale Centre Ville, Montreal, Quebec, Canada, H3C3J7
    Trends Genet 22:225-31. 2006
    ..We propose that selecting only data that contain minimal nonphylogenetic signals takes full advantage of phylogenomics and markedly reduces incongruence...
  83. pmc Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination
    David Alvaro
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, USA
    PLoS Genet 3:e228. 2007
    ..Our cell biological approach demonstrates the diversity of processes that converge on homologous recombination, protect against spontaneous DNA damage, and facilitate efficient repair...
  84. pmc Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence
    Bethann S Hromatka
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Biol Cell 16:4814-26. 2005
    ....
  85. pmc Additions, losses, and rearrangements on the evolutionary route from a reconstructed ancestor to the modern Saccharomyces cerevisiae genome
    Jonathan L Gordon
    Smurfit Institute of Genetics, Trinity College, Dublin, Ireland
    PLoS Genet 5:e1000485. 2009
    ..Many of the gained genes in S. cerevisiae have functions associated with ethanol production, growth in hypoxic environments, or the uptake of alternative nutrient sources...
  86. ncbi Translational and rotational settings of H2A.Z nucleosomes across the Saccharomyces cerevisiae genome
    Istvan Albert
    Center for Comparative Genomics and Bioinformatics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nature 446:572-6. 2007
    ..Transcriptional start sites tended to reside about one helical turn inside the nucleosome border. These findings reveal an intimate relationship between chromatin architecture and the underlying DNA sequence it regulates...
  87. ncbi Genome-wide replication-independent histone H3 exchange occurs predominantly at promoters and implicates H3 K56 acetylation and Asf1
    Anne Rufiange
    Centre de recherche en cancérologie de l Université Laval, L Hôtel Dieu de Québec CHUQ, Quebec, Canada
    Mol Cell 27:393-405. 2007
    ..Taken together, our data underline the dynamic nature of replication-independent nucleosome assembly/disassembly, specify a link to transcription, and implicate Asf1 and H3 K56 acetylation...
  88. ncbi Fungal secondary metabolism - from biochemistry to genomics
    Nancy P Keller
    University of Wisconsin Madison, Department of Plant Pathology, 882 Russell Labs, 1630 Linden Drive, Madison, Wisconsin 53706, USA
    Nat Rev Microbiol 3:937-47. 2005
    ....
  89. pmc Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
    P James
    Department of Biomolecular Chemistry, University of Wisconsin, Madison 53706, USA
    Genetics 144:1425-36. 1996
    ..Our analysis indicates that the libraries and host strain provide significant improvements in both the number of interacting clones identified and the efficiency of two-hybrid selections...
  90. ncbi Nep1-like proteins from plant pathogens: recruitment and diversification of the NPP1 domain across taxa
    Mark Gijzen
    Agriculture and Agri Food Canada, 1391 Sandford Street, London, Ont, Canada N5V 4T3
    Phytochemistry 67:1800-7. 2006
    ..Interest in NLPs is gaining momentum as more members of this protein family are discovered in more species of plant pathogens...
  91. pmc Variations in stress sensitivity and genomic expression in diverse S. cerevisiae isolates
    Daniel J Kvitek
    Laboratory of Genetics, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS Genet 4:e1000223. 2008
    ..These results highlight the value of understanding the genetic basis of phenotypic variation and raise caution about using laboratory strains for comparative genomics...
  92. ncbi A yeast hybrid provides insight into the evolution of gene expression regulation
    Itay Tirosh
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    Science 324:659-62. 2009
    ..These results provide insights on the regulatory changes in cis and trans during the divergence of species and upon hybridization...
  93. ncbi Exploring genetic interactions and networks with yeast
    Charles Boone
    Banting and Best Department of Medical Research and Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto M5S 3E1, Canada
    Nat Rev Genet 8:437-49. 2007
    ..A comparative understanding of genetic-interaction networks promises insights into some long-standing genetic problems, such as the nature of quantitative traits and the basis of complex inherited disease...
  94. pmc Evolutionary programming as a platform for in silico metabolic engineering
    Kiran Raosaheb Patil
    Center for Microbial Biotechnology, BioCentrum DTU, Building 223, Technical University of Denmark, DK 2800 Kgs, Lyngby, Denmark
    BMC Bioinformatics 6:308. 2005
    ....
  95. ncbi A complete survey of Trichoderma chitinases reveals three distinct subgroups of family 18 chitinases
    Verena Seidl
    Research Area Gene Technology and Applied Biochemistry, Institute of Chemical Engineering, TU Vienna, Austria
    FEBS J 272:5923-39. 2005
    ..jecorina chitinases, and those from other filamentous fungi, including hypothetical proteins of annotated fungal genome databases, showed that the fungal chitinases can be divided into three groups: groups A and B (corresponding ..
  96. pmc A catalog of neutral and deleterious polymorphism in yeast
    Scott W Doniger
    Computational Biology Program, Washington University, St Louis, Missouri, United States of America
    PLoS Genet 4:e1000183. 2008
    ..Our results show that the genome sequences of both closely and distantly related species provide a means of identifying deleterious polymorphisms that disrupt functionally conserved coding and noncoding sequences...
  97. ncbi Widespread bidirectional promoters are the major source of cryptic transcripts in yeast
    Helen Neil
    Institut Pasteur, Unité de Génétique des Interactions Macromoléculaires, CNRS, URA2171, 75015 Paris, France
    Nature 457:1038-42. 2009
    ....
  98. ncbi Transposable elements in filamentous fungi
    Marie Josée Daboussi
    Institut de Genetique et Microbiologie, Universite Paris Sud, F 91405 Orsay cedex, France
    Annu Rev Microbiol 57:275-99. 2003
    ..the evolutionary dynamics of TEs should provide important insights into the interactions between TEs and the fungal genome. Another issue of major significance is the practical applications of TEs in gene tagging and population ..
  99. pmc SGD: Saccharomyces Genome Database
    J M Cherry
    Department of Genetics, Stanford University, Stanford, CA 94305 5120, USA
    Nucleic Acids Res 26:73-9. 1998
    ..SGD can be accessed via the World Wide Web at http://genome-www.stanford.edu/Saccharomyces/..
  100. pmc GC content and recombination: reassessing the causal effects for the Saccharomyces cerevisiae genome
    Marie Claude Marsolier-Kergoat
    Institut de Biologie et de Technologies de Saclay, Commissariat àl Energie Atomique Saclay, 91191 Gif sur Yvette, France
    Genetics 183:31-8. 2009
    ..These results pave the way for further analyses aimed at the detailed untangling of drives involved in the evolutionary shaping of the yeast genome...
  101. pmc The Aspergillus Genome Database, a curated comparative genomics resource for gene, protein and sequence information for the Aspergillus research community
    Martha B Arnaud
    Department of Genetics, Stanford University Medical School, Stanford, CA 94305 5120, USA
    Nucleic Acids Res 38:D420-7. 2010
    ..All of these data are freely available at http://www.aspgd.org. We welcome feedback from users and the research community at aspergillus-curator@genome.stanford.edu...

Research Grants64

  1. A genetic engineering strategy for the improved production of the anti-helminthic
    JEFFREY DAVID KITTENDORF; Fiscal Year: 2012
    ..Specifically, Alluvium's approach is guided by the DNA sequence of the fungal genome in which key regulatory and/or biosynthetic genes responsible for paraherquamide production have been ..
  2. Desaturases and Acetylenases from Basidiomycete Fungi
    ROBERT MINTO; Fiscal Year: 2004
    ..A delta-12 desaturase sequence mined from the White Rot Fungal Genome project will be isolated and characterized...
  3. ANTISENSE REPRESSION IN CRYPTOCOCCUS NEOFORMANS
    Gary Cox; Fiscal Year: 2000
    ..What is needed is a rapid means to evaluate the function of multiple genes in the fungal genome to identify new antifungal targets...
  4. Twenty Third Fungal Genetics Conference
    Marc Orbach; Fiscal Year: 2005
    ..nematodes, insects and fungi, Fungal Circadian Rhythms and photobiology, Applications resulting from fungal genome projects, Teaching fungal biology and genetics, Proteomics of filamentous fungi, Basidiomycete genomics, ..
  5. Gene Duplication and Genome Evolution
    Austin Hughes; Fiscal Year: 2004
    ..5) Examining the role of transposable elements in duplication of genomic segments by testing for nonrandom association between these elements and putatively duplicated blocks in the yeast genome. ..
  6. Characterization of a large protein interaction network
    Andreas Wagner; Fiscal Year: 2005
    ..The proposed work will put this speculation to an end for a key genetic network, some of whose conserved components are also involved in the etiology of human disease. ..
  7. EVOLUTION OF IMMUNE RECOGNITION AND EVASION
    Austin L Hughes; Fiscal Year: 2010
    ..In addition, by increasing our understanding of the population diversity and evolutionary history of human immune system genes, this research will enhance our knowledge of human immune function in health and disease. ..
  8. Genetic analysis of Cryptococcus neoformans virulence
    Joseph Heitman; Fiscal Year: 2009
    ..These studies will enable a genome-wide definition of the gene set contributing to virulence of this common human fungal pathogen. ..
  9. Genetics of mating and fruiting in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2010
    ..neoformans and C. gattii applicable to development of treatment approaches, diagnostics, or environmental interventions to reduce exposure to infectious spores. ..
  10. Role of Calcineurin in Fungal Virulence
    Joseph Heitman; Fiscal Year: 2009
    ..Importantly, this pathway can be targeted for therapeutic intervention using non-immunosuppressive calcineurin inhibitors that retain antifungal activity and synergistic drug combinations that we have discovered. ..
  11. GPCR signaling cascades in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. Microarray Expression Analysis of Burkholderia Mallei
    William Nierman; Fiscal Year: 2003
    ..Function and virulence validation of the identified virulence genes will be explored by construction and phenotype analysis of targeted knockout strains. ..
  13. Regulation of Burkholderia mallei virulence genes
    William Nierman; Fiscal Year: 2005
    ..It will provide critical information on virulence control and virulence mechanisms of B. mallei and will be crucial to the development of effective therapeutic interventions and vaccine strategies. ..
  14. Host-Pathogen Interactions in Invasive Aspergillosis
    WILLIAM CHARLES NIERMAN; Fiscal Year: 2010
    ..necessary to maintain protective immunity against the invading fungus. This hithertn inaccessible ... in order to >.E =.m m'- N'3 ..' 'C3 _.n '-' a.. m._ o'< m- ..
  15. Transcriptional Integration of Metabolism
    ELTON YOUNG; Fiscal Year: 2007
    ..abstract_text> ..
  16. The Transcriptome of Pathogenic Aspergillus Fumigatus
    William Nierman; Fiscal Year: 2003
    ..abstract_text> ..
  17. Sequence Determinants of Meiotic Recombination Hotspots
    Walter Steiner; Fiscal Year: 2007
    ..pombe are also active in the distantly related budding yeast Saccharomyces cerevisiae. Sequences that are active in both organisms may be widely conserved among eukaryotes, including man. [unreadable] [unreadable] [unreadable]..
  18. Genome Instability in Cells and Tissues of the Zebrafish
    Forrest Spencer; Fiscal Year: 2006
    ..abstract_text> ..
  19. REGULATION OF MEIOTIC DEVELOPMENT BY MTS1-MTS2 PROTEIN
    WAYNE WAHLS; Fiscal Year: 2004
    ..4) To test alternative hypotheses that the Mts1-Mts2-M26 complex either enhances the use of a pre-existing recombinational initiation site or creates a new initiation site. The PI request four years of support to carry out this study. ..
  20. ASM Conference on Candida and Candidiasis
    Aaron Mitchell; Fiscal Year: 2008
    ..The conference will help chart the course of future research and facilitate the urgent necessity to understand, treat, and prevent disease. [unreadable] [unreadable] [unreadable]..
  21. Molecular Targets of Novel Antifungal Compounds
    Ameeta Agarwal; Fiscal Year: 2008
    ..This work will provide a starting point in the development of new antifungal therapies. [unreadable] [unreadable] [unreadable]..
  22. Pheromone Signaling in Pneumocystis Carinii
    Charles Thomas; Fiscal Year: 2009
    ..Through these investigations we hope to gain insights into P. carinii biology which may provide new information for novel drug development to treat PCP. ..
  23. Computational Analysis of Retinal Regulatory Interactions: structure and dynamics
    Jiang Qian; Fiscal Year: 2010
    ..Beyond investigation of retinal disease, the computational programs developed in this proposal should also be generally useful for a broad community. ..
  24. Genetic Determinants of Genomic Plasticity and Chromosome Evolution
    Forrest A Spencer; Fiscal Year: 2010
    ..In humans, distinct chromosome nondisjunction signatures that reveal specific dysfunctional pathways could enhance diagnosis and treatment of disease. ..
  25. Biochemistry of recombination in gametogenesis
    Wayne P Wahls; Fiscal Year: 2010
    ....
  26. Comparative Genomics of Francisella
    George Weinstock; Fiscal Year: 2006
    ..abstract_text> ..
  27. Molecular & Cellular Bioenergetics Gordon Conf. 2005
    Patricia Kane; Fiscal Year: 2005
    ..The format of the Gordon Conference is designed to maximize opportunities for discussion and to encourage presentation of the latest results in the field. ..
  28. Pharmacogenomics/natural products + antifungal activity
    John Cleary; Fiscal Year: 2004
    ..Probing this array with eukaryotic mRNA from cells exposed to novel antifungals would predict common mechanism of action and likelihood of toxicity, activity and resistance. ..
  29. OXYGEN SENSING BY THE RESPIRATORY CHAIN
    KURT KWAST; Fiscal Year: 2005
    ....
  30. RIBOSOMAL FRAMESHIFTING AS A PROBE OF 5S RRNA FUNCTION
    JONATHAN DINMAN; Fiscal Year: 2004
    ..The proposed research will serve to further our understanding of this ubiquitous yet little understood rRNA and will place us in the unique position to link functional aspects of 5S rRNA to its structure within the ribosome. ..
  31. ENTAMOEBA HISTOLYTICA GENOME PROJECT
    Brendan Loftus; Fiscal Year: 2002
    ..The vast majority of the research needs and applications will be met by obtaining 99 percent of the genomic sequence. ..
  32. 2004 FASEB Summer Conference on Trace Element Metabolism
    David Eide; Fiscal Year: 2004
    ..These individuals will be encouraged to present posters to be displayed in two poster sessions. We also will obtain funds to provide travel awards for up to 10 postdocs or senior graduate students. ..
  33. Francisella Genomics
    George Weinstock; Fiscal Year: 2004
    ..tularensis contains a high proportion of unique genes compared to other bacterial genomes. Therefore, knowledge of the complete genome sequences of F. tularensis strains is needed for the understanding of the virulence mechanisms. ..
  34. The Rate and Molecular Spectrum of Spontaneous Mutations
    Michael Lynch; Fiscal Year: 2009
    ....
  35. New strategies for identification of C. albicans fluconazole resistance gene
    Aaron Mitchell; Fiscal Year: 2004
    ..These approaches will define the regulators that govern known resistance mechanisms and may reveal the regulators that govern other clinically relevant resistance mechanisms. ..
  36. Azoles and Candida in AIDS - A Whole Cell Response
    THEODORE WHITE; Fiscal Year: 2004
    ....
  37. REGULATION OF DROSOPHILA NEUROMUSCULAR DEVELOPMENT
    Michael Young; Fiscal Year: 2004
    ..e) Factors regulating Notch transport to and from the cell surface, and controlling nuclear translocation of Notch will be identified and characterized using certain transport deficient Notch proteins. ..
  38. Chlamydia co-option of Eukaryotic Lipid Droplets
    Raphael H Valdivia; Fiscal Year: 2010
    ..abstract_text> ..
  39. Implications of Genomics Research on Racial Definition
    Seymour Garte; Fiscal Year: 2003
    ..A new paradigm of gene-specific variation will be developed for a biomedically useful method of division of the human population into groups based on criteria different from current definitions of race. ..
  40. Zinc Transporters and Intracellular Zinc Trafficking
    David Eide; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  41. Molecular Mechanisms of Genome Duplication
    ZENGJIAN CHEN; Fiscal Year: 2009
    ..abstract_text> ..
  42. Sterol Sensing and Transport in Model Eukaryote
    STEPHEN STURLEY; Fiscal Year: 2008
    ..We will test the ramifications of overexpression or knockdown of human ARVl in various tissue culture cell models. Lipid efflux to extracellular acceptors will be studied in detail. ..
  43. A Genomics Approach to Study C. neoformans var. grubii
    Fred Dietrich; Fiscal Year: 2006
    ..The resulting data and material from this study will expand our knowledge of the nature of pathogenicity in this important human fungal pathogen. [unreadable] [unreadable]..
  44. Analysis of Somatic Mutations in Cancer of the Kidney
    WAYNE VEDECKIS; Fiscal Year: 2005
    ..B) Is there a correlation between other suspected risk factors, hypertension and obesity, and p53 gene mutation prevalence and spectrum? (C) Is there a correlation between survival and p53 gene mutation prevalence and spectrum? ..
  45. A Skpl-containing Complex Regulating V-ATPase Activity
    Patricia Kane; Fiscal Year: 2005
    ..abstract_text> ..
  46. A compendium of gene expression in stationary phase
    Margaret Werner Washburne; Fiscal Year: 2005
    ..parent abstract not available ..
  47. Azoles and Candida in AIDS-Transcriptional Regulation
    THEODORE WHITE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  48. Vacuole expansion during flamentation in Candida
    Joy Sturtevant; Fiscal Year: 2006
    ..The information obtained in this study on the role of the fungal vacuole in pathogenesis may also aid in the design of new anti-fungal treatment strategies. ..
  49. Yeast Aspartyl Proteases in Cell Wall Integrity
    DAMIAN KRYSAN; Fiscal Year: 2007
    ..A team of outstanding collaborators and advisors has been assembled to provide additional mentoring and support as the investigator makes the transition to an independent researcher. [unreadable] [unreadable]..
  50. MOLECULAR AND CELLULAR STUDIES OF CIRCADIAN RHYTHMS
    Michael Young; Fiscal Year: 2008
    ..regulate nuclear accumulation of PER? How does PER phosphorylation influence phosphorylation of TIM? (6) Does DBT's physical association with PER put other substrates of the kinase under circadian control? [unreadable] [unreadable]..
  51. Therapeutic targeting of HSP90-dependent signaling
    Larry Karnitz; Fiscal Year: 2008
    ..Collectively, these studies will provide information about the ability to alter the response of ovarian cancer cells to chemotherapeutic agents in vitro and in the clinical setting. [unreadable] [unreadable]..
  52. Identification of Coxiella burnetti Effector Proteins
    RAPHAEL VALDIVIA; Fiscal Year: 2008
    ..We predict that these factors will be attractive candidates for the design of new therapeutics and vaccines. [unreadable] [unreadable] [unreadable] [unreadable]..
  53. A Model Signaling Mucin in Yeast
    Paul Cullen; Fiscal Year: 2008
    ..We use a model genetic system - budding yeast - to investigate mucin function in MAP kinase pathway activation, cell adherence, and biofilm formation. [unreadable] [unreadable] [unreadable]..
  54. Mitochondria and Carcinogenesis
    Keshav K Singh; Fiscal Year: 2010
    ..The proposed study will help determine the contribution of mutant mtDNA to the development of human cancer. ..
  55. S. Cerevisiae Emergence of an Opportunistic Pathogen
    JOHN MCCUSKER; Fiscal Year: 2009
    ..cerevisiae population both phenotypically, for virulence and virulence-associated traits, and genotypically, for virulence-related genes. ..
  56. ANALYSIS OF GENETICALLY & ENVIRONMENTALLY OVERLAPPING YEAST QUANTITATIVE TRAITS
    John H McCusker; Fiscal Year: 2010
    ..Therefore, an improved understanding of quantitative traits will aid our understanding of how a harmless commensal/saprophytic yeast can become an opportunistic pathogen. ..
  57. PHASE VARIATION IN SACCHAROMYCES CEREVISIAE
    JOHN MCCUSKER; Fiscal Year: 2003
    ..The PHI genes will be introduced to the non-phase variable laboratory strain, 288c, in efforts to reconstruct phase variation. ..
  58. GENETIC DIVERSITY AND COMPLEX TRAITS IN S CEREVISIAE
    JOHN MCCUSKER; Fiscal Year: 2002
    ..the development of S. cerevisiae as genetically manipulable model for the pathogenic fungi and as a host for the interspecific reconstitution of fungal virulence. ..
  59. Fungal-specific drug targets: static vs. cidal starvation & toxic intermediates
    JOHN MCCUSKER; Fiscal Year: 2008
    ..The identification of fungicidal antifungal drugs, which is a long-term goal, will greatly improve human health. [unreadable] [unreadable] [unreadable]..
  60. Cleveland Cell Biology Symposium: Regulation
    ALAN TARTAKOFF; Fiscal Year: 2004
    ..The results should be an intense synthesis of knowledge which will be stimulating for both students and established faculty. ..
  61. Towards a general theory of evolutionary capacitance
    Joanna Masel; Fiscal Year: 2009
    ..Since direct experiments on capacitance cannot be performed in humans, the theoretical and predictive approach described here is particularly important for understanding the scope of capacitance in explaining human variation. ..
  62. A Genome Sequence Survey of Enterocytozoon bieneusi
    Donna Akiyoshi; Fiscal Year: 2006
    ..c. Establishment of a website to provide access to the sequence data and clones by the scientific community. ..