alpha chain t cell antigen receptor gene rearrangement

Summary

Summary: Ordered rearrangement of T-cell variable gene regions coding for the alpha-chain of antigen receptors.

Top Publications

  1. ncbi Preferential positive selection of V alpha 2+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor V alpha a haplotypes: determination with a V alpha 2-specific monoclonal antibody
    H Pircher
    Institute of Pathology, University Hospital, Zurich, Switzerland
    Eur J Immunol 22:399-404. 1992
  2. ncbi Ordered and coordinated rearrangement of the TCR alpha locus: role of secondary rearrangement in thymic selection
    C Huang
    Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
    J Immunol 166:2597-601. 2001
  3. ncbi Failure of HY-specific thymocytes to escape negative selection by receptor editing
    Thorsten Buch
    Institute for Genetics, University of Cologne, Weyertal 121, D 50931 Cologne, Germany
    Immunity 16:707-18. 2002
  4. pmc Highly restricted T cell repertoire shaped by a single major histocompatibility complex-peptide ligand in the presence of a single rearranged T cell receptor beta chain
    Y Fukui
    Department of Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Exp Med 188:897-907. 1998
  5. ncbi Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes
    Jian Guo
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Nat Immunol 3:469-76. 2002
  6. ncbi Premature TCR alpha beta expression and signaling in early thymocytes impair thymocyte expansion and partially block their development
    H D Lacorazza
    Laboratory of T Cell Development, Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 166:3184-93. 2001
  7. pmc Rapid deletion of rearranged T cell antigen receptor (TCR) Valpha-Jalpha segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR alpha chain gene and positive selection in the T cell repertoire formation
    F Wang
    Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 95:11834-9. 1998
  8. ncbi Function of the TCR alpha enhancer in alphabeta and gammadelta T cells
    B P Sleckman
    Children s Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 7:505-15. 1997
  9. ncbi Defect in rearrangement of the most 5' TCR-J alpha following targeted deletion of T early alpha (TEA): implications for TCR alpha locus accessibility
    I Villey
    Developpement Normal et Pathologique du Systeme Immunitaire, INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Immunity 5:331-42. 1996
  10. ncbi Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus
    Michael S Krangel
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunol Rev 200:224-32. 2004

Research Grants

  1. Control Of Tcr Data And Tcr Alpha Rearrangement
    MICHAEL KRANGEL; Fiscal Year: 2005
  2. T CELL RESPONSE TO A PERIODONTAL PATHOGEN
    Ellen Kraig; Fiscal Year: 2002
  3. A novel protein regulating thymocyte development
    NICHOLAS R GASCOIGNE; Fiscal Year: 2010
  4. Molecular Interactions in the Aging Immunological Synapse
    NICHOLAS GASCOIGNE; Fiscal Year: 2008
  5. NOVEL APPROACH TO CHLAMYDIA VACCINE DEVELOPMENT
    Ellen Kraig; Fiscal Year: 2007
  6. Leica TCSSP2RS two-photon microscope for in vivo imaging
    NICHOLAS GASCOIGNE; Fiscal Year: 2006
  7. SOLUBLE T CELL RECEPTOR STUDIES ON MHC RESTRICTION
    NICHOLAS GASCOIGNE; Fiscal Year: 2006
  8. Real-time molecular interactions in tolerance induction
    NICHOLAS GASCOIGNE; Fiscal Year: 2003
  9. Cannabinoid Receptor Dynamics in T Cell Activation
    NICHOLAS GASCOIGNE; Fiscal Year: 2002
  10. EVOLUTIONARY MODELS OF THE IMMUNE SYSTEM
    Melvin Cohn; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications133 found, 100 shown here

  1. ncbi Preferential positive selection of V alpha 2+ CD8+ T cells in mouse strains expressing both H-2k and T cell receptor V alpha a haplotypes: determination with a V alpha 2-specific monoclonal antibody
    H Pircher
    Institute of Pathology, University Hospital, Zurich, Switzerland
    Eur J Immunol 22:399-404. 1992
    ....
  2. ncbi Ordered and coordinated rearrangement of the TCR alpha locus: role of secondary rearrangement in thymic selection
    C Huang
    Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
    J Immunol 166:2597-601. 2001
    ..Thus, the lack of allelic exclusion and TCR alpha secondary rearrangement play a key role in the formation of a functional T cell repertoire...
  3. ncbi Failure of HY-specific thymocytes to escape negative selection by receptor editing
    Thorsten Buch
    Institute for Genetics, University of Cologne, Weyertal 121, D 50931 Cologne, Germany
    Immunity 16:707-18. 2002
    ..In the absence of the restricting MHC element, however, developing thymocytes replaced the inserted TCR alpha exon efficiently...
  4. pmc Highly restricted T cell repertoire shaped by a single major histocompatibility complex-peptide ligand in the presence of a single rearranged T cell receptor beta chain
    Y Fukui
    Department of Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Exp Med 188:897-907. 1998
    ..Our findings provide definitive evidence that specific recognition of self-peptides by TCR could be involved in positive selection of thymocytes...
  5. ncbi Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes
    Jian Guo
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Nat Immunol 3:469-76. 2002
    ..Rather, it limits the progression of rearrangement along the J(alpha) locus and the opportunities for positive selection, thereby regulating the TCRalpha repertoire...
  6. ncbi Premature TCR alpha beta expression and signaling in early thymocytes impair thymocyte expansion and partially block their development
    H D Lacorazza
    Laboratory of T Cell Development, Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 166:3184-93. 2001
    ....
  7. pmc Rapid deletion of rearranged T cell antigen receptor (TCR) Valpha-Jalpha segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR alpha chain gene and positive selection in the T cell repertoire formation
    F Wang
    Center for Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 95:11834-9. 1998
    ..These results suggest that secondary rearrangements of the TCR alpha chain gene play an important role in the formation of the T cell repertoire...
  8. ncbi Function of the TCR alpha enhancer in alphabeta and gammadelta T cells
    B P Sleckman
    Children s Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Immunity 7:505-15. 1997
    ..Our findings imply that E alpha function is not limited to the TCR alpha components of the TCRalpha/delta locus or to the alpha beta lineage; rather, E alpha function is important in both alphabeta and gammadelta lineage T cells...
  9. ncbi Defect in rearrangement of the most 5' TCR-J alpha following targeted deletion of T early alpha (TEA): implications for TCR alpha locus accessibility
    I Villey
    Developpement Normal et Pathologique du Systeme Immunitaire, INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Immunity 5:331-42. 1996
    ..These results are consistent with TEA acting as a "rearrangement-focusing" element, targeting the primary waves of V alpha-J alpha recombination to the most 5' J alpha S in an ongoing TCR-J alpha rearrangement model...
  10. ncbi Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus
    Michael S Krangel
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunol Rev 200:224-32. 2004
    ..We provide here a current view of cis-acting mechanisms that enforce the TCRalpha/delta locus developmental program, and we emphasize the unresolved issues that command the attention of our and other laboratories...
  11. ncbi TCRA gene rearrangement in immature thymocytes in absence of CD3, pre-TCR, and TCR signaling
    S J Mancini
    Laboratoire d Immunochimie, Commissariat a l Energie Atomique Grenoble, Departement de Biologie Moleculaire et Structurale, Institut National de la Santé et de la Recherche Médicale U548, Universite Joseph Fourier, Grenoble, France
    J Immunol 167:4485-93. 2001
    ..Taken together, these results provide new insights into the molecular control of early T cell differentiation...
  12. pmc Role for rearranged variable gene segments in directing secondary T cell receptor alpha recombination
    Abbas Hawwari
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:903-7. 2007
    ..The data provide the mechanistic basis for a model of primary and secondary T cell receptor alpha recombination in which recombination events progress in multiple small steps down the Jalpha array...
  13. ncbi Developmentally regulated and lineage-specific rearrangement of T cell receptor Valpha/delta gene segments
    P Pereira
    Unité du Développement des Lymphocytes, Centre National de la Recherche Scientifique URA 1961, Institut Pasteur, Paris, France
    Eur J Immunol 30:1988-97. 2000
    ....
  14. ncbi Analysis of the TCR alpha-chain rearrangement profile in human T lymphocytes
    Patrizia Fuschiotti
    Laboratoire d Immunochimie, Commissariat à l Energie Atomique Grenoble Département des Réponses et Dynamique Cellulaire, Institut National de la Sante et de la Recherche Medicale, U548, Grenoble, France
    Mol Immunol 44:3380-8. 2007
    ....
  15. ncbi Intestinal alpha beta T cells differentiate and rearrange antigen receptor genes in situ in the human infant
    Amanda M Williams
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 173:7190-9. 2004
    ..Thus, mucosal T cell responsiveness to environmental Ag is shaped in situ during early life...
  16. pmc Quantitative and qualitative changes in V-J alpha rearrangements during mouse thymocytes differentiation: implication for a limited T cell receptor alpha chain repertoire
    Nicolas Pasqual
    Laboratoire d Immunochimie, Commissariat a l Energie Atomique, Institut National de la Sante et de la Recherche Medicale, Unité 548, Universite Joseph Fourier, 38054 Grenoble Cedex 9, France
    J Exp Med 196:1163-73. 2002
    ..These results provide a new insight into TCR alpha repertoire size and suggest a scenario for V usage during differentiation...
  17. pmc Regulation of T cell receptor alpha gene assembly by a complex hierarchy of germline Jalpha promoters
    Abbas Hawwari
    The Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Immunol 6:481-9. 2005
    ..Central promoter derepression also occurred after primary rearrangement, thereby providing a mechanism to target secondary recombination events...
  18. ncbi Differential chronology of TCRADV2 gene use by alpha and delta chains of the mouse TCR
    E Jouvin-Marche
    CEA Grenoble, Laboratoire d Immunochimie, INSERM U 238, DBMS, Grenoble, France
    Eur J Immunol 28:818-27. 1998
    ..These results support independent control of TCRA and TCRD gene assembly...
  19. ncbi Early activation of TCR alpha gene rearrangement in fetal thymocytes
    M Rytkönen-Nissinen
    Department of Clinical Microbiology, University of Kuopio, Finland
    Eur J Immunol 29:2288-96. 1999
    ..In addition, Vdelta1 Ddelta2 J alpha50 gene segments are replaced by secondary alpha rearrangements, indicating that thymocytes with the early alpha rearrangement are committed to the alphabeta lineage...
  20. ncbi Both TCR alpha and TCR delta chain diversity are regulated during thymic ontogeny
    M Gallagher
    , , , , Grenoble, France
    J Immunol 167:1447-53. 2001
    ..Control of these waves appears to be linked directly to the ADV segments and their local chromatin environment, which may change over the course of T cell differentiation...
  21. ncbi Preferential ADV-AJ association during recombination in the mouse T-cell receptor alpha/delta locus
    C Aude-Garcia
    Commissariat a l Energie Atomique Grenoble, Departement de Biologie Moleculaire et Structurale, INSERM U238, Universite J Fourier, Grenoble, France
    Immunogenetics 52:224-30. 2001
    ..Taken together, our results indicate that, in addition to the progressive opening of the ADV and AJ loci, the chromosomal location of ADV and AJ genes is a factor affecting AJ use in BALB/c mice...
  22. ncbi TEA regulates local TCR-Jalpha accessibility through histone acetylation
    Laurent Mauvieux
    Developpement Normal et Pathologique du Systeme Immunitaire, INSERM U429, Hopital Necker Enfants Malades, Paris, France
    Eur J Immunol 33:2216-22. 2003
    ..TEA-dependent histone acetylation of the most upstream Jalpha segments leads to enhanced DNA accessibility thus optimizing TCRJalpha usage and increasing Ag receptor diversity potential...
  23. pmc T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production
    H T Petrie
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York 10021, USA
    J Exp Med 182:121-7. 1995
    ....
  24. pmc The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement
    F Davodeau
    INSERM U.463, Institut de Biologie, 9 quai Moncousu, 44035 Nantes Cedex 01, France
    EMBO J 20:4717-29. 2001
    ....
  25. ncbi T early alpha (TEA) regulates initial TCRVAJA rearrangements and leads to TCRJA coincidence
    L Mauvieux
    Developpement Normal et Pathologique du Systeme Immunitaire, INSERM U429, France
    Eur J Immunol 31:2080-6. 2001
    ..In a model of multiple waves of TCRVAJA recombination, this cis-regulatory effect of TEA allows for the scanning of the entire TCRJA cluster, thereby increasing the TCR alpha/beta diversity potential...
  26. ncbi Molecular analysis of skewed Tcra-V gene use in T-cell receptor beta-chain transgenic mice
    R P Burns
    University of Rochester Cancer Center and the Department of Microbiology and Immunology, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Immunogenetics 47:107-14. 1998
    ....
  27. ncbi Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors
    Takeshi Egawa
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Immunity 22:705-16. 2005
    ..Our results indicate that even though CD1d binding DP thymocytes have yet to be observed, Valpha14-Jalpha18 rearrangement in these cells is required for development of iNKT cells...
  28. ncbi The TCRalpha locus control region specifies thymic, but not peripheral, patterns of TCRalpha gene expression
    Faith Harrow
    Department of Biological Sciences, City University of New York, Hunter College, New York, NY 10021, USA
    J Immunol 175:6659-67. 2005
    ....
  29. pmc Clonable progenitors committed to the T lymphocyte lineage in the mouse bone marrow; use of an extrathymic pathway
    S Dejbakhsh-Jones
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 98:7455-60. 2001
    ..Progenitors were capable of rapidly reconstituting athymic hosts. In conclusion, the clonable bone marrow progenitors were capable of T cell reconstitution predominantly by means of an extrathymic pathway...
  30. ncbi The repertoire of killer cell Ig-like receptor and CD94:NKG2A receptors in T cells: clones sharing identical alpha beta TCR rearrangement express highly diverse killer cell Ig-like receptor patterns
    M Uhrberg
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 166:3923-32. 2001
    ..Remarkably, among 55 T cell clones sharing the same TCR alpha beta rearrangement 18 different KIR phenotypes were seen, suggesting that KIR expression was initiated subsequently to TCR rearrangement...
  31. ncbi Development and selection of gammadelta T cells
    Na Xiong
    Department of Molecular and Cell Biology, Cancer Research Laboratory, University of California, Berkeley, CA, USA
    Immunol Rev 215:15-31. 2007
    ..This research suggests a coordination of molecularly programmed events and cellular selection, which enables specialization of the thymus for production of distinct T-cell subsets at different stages of development...
  32. ncbi Developmental stage-specific regulation of TCR-alpha-chain gene assembly by intrinsic features of the TEA promoter
    Ching Yu Huang
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 179:449-54. 2007
    ....
  33. pmc A hypothesis accounting for the paradoxical expression of the D gene segment in the BCR and the TCR
    Melvin Cohn
    Conceptual Immunology Group, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Eur J Immunol 38:1779-87. 2008
    ..This assumption operates in determining haplotype exclusion for the BCR and in regulating the signaling orientation for the TCR. Relevant data as well as a definitive experiment challenging the validity of this hypothesis, are discussed...
  34. ncbi A critical role for CD2 in both thymic selection events and mature T cell function
    T Sasada
    Laboratory of Immunobiology, Dana Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 166:2394-403. 2001
    ..Collectively, these findings show that CD2 plays a role in pre-TCR function in double-negative thymocytes, TCR selection events during thymocyte development, and TCR-stimulated cytokine production in mature T cells...
  35. pmc T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires
    Abdelbasset Hamrouni
    INSERM U503, Centre d Etudes et de Recherches en Virologie et Immunologie CERVI, 69007 Lyon, France
    J Exp Med 197:601-14. 2003
    ..Thus, the diversity of TCR-alpha's selected as partners for a given VDJ-beta rearrangement into the mature TCR repertoire may indeed be very limited...
  36. ncbi Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells
    M Tada
    Precursory Research for Embryonic Science and Technology (PRESTO, JST, Kawaguchi-shi, Japan
    Curr Biol 11:1553-8. 2001
    ..Thus, ES cells have the capacity to reset certain aspects of the epigenotype of somatic cells to those of ES cells...
  37. pmc Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo
    Jennifer L Matsuda
    La Jolla Institute for Allergy and Immunology, and Division of Biological Sciences, University of California, San Diego, CA, USA
    Proc Natl Acad Sci U S A 100:8395-400. 2003
    ....
  38. ncbi Self-recognition and the biased mature repertoire in TCR beta transgenic mice: the exception that supports the rule
    Xin He
    Trends Immunol 23:467-9. 2002
    ..Therefore, the KB TCR beta chain transgenic mice offer a unique opportunity for addressing this issue...
  39. ncbi Low thymic output and reduced heterogeneity of alpha/beta, but not gamma/delta, T lymphocytes in infants with ataxia-telangiectasia
    R Micheli
    Pediatric Neuropsychiatry, Spedali Civili of Brescia, Brescia, Italy
    Neuropediatrics 34:165-7. 2003
    ..Our data indicate that ATM mutation limits the generation of a wide alpha/beta T cell repertoire and this feature can be responsible for the immunodeficiency observed in ataxia-telangiectasia babies...
  40. ncbi Cutting edge: V alpha 14-J alpha 281 NKT cells naturally regulate experimental autoimmune encephalomyelitis in nonobese diabetic mice
    Lennart T Mars
    Institut National de la Sante et de la Recherche Medicale, Unité 546, Hopital Pitie Salpetriere, Paris, France
    J Immunol 168:6007-11. 2002
    ..Our findings indicate that enrichment and/or stimulation of CD1d-dependent NKT cells may be used as a novel strategy to treat CNS autoimmunity...
  41. ncbi The central tolerance response to male antigen in normal mice is deletion and not receptor editing
    Philmore O Holman
    Department of Laboratory Medicine and Pathology and Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 171:4048-53. 2003
    ..Thus, it would appear that receptor editing is not a predominant tolerance mechanism for this self-Ag...
  42. ncbi Inhibition of early tumor growth requires J alpha 18-positive (natural killer T) cells
    Trina J Stewart
    Centre for Immunology and Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, 4102, Australia
    Cancer Res 63:3058-60. 2003
    ..This suggests that recruitment/activation of J alpha 18(+) NKT cells is an important consideration during the immune therapy of early stage tumors...
  43. ncbi T-cell receptor transgenic response to an endogenous polymorphic autoantigen determines susceptibility to diabetes
    Mary E Pauza
    Department of Medical Microbiology and Immunology, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    Diabetes 53:978-88. 2004
    ..Thus, the generation of 6.9TCR transgenic mice provides a model of autoimmune diabetes whereby controlled expression of an endogenous polymorphic autoantigen effectively determines disease development...
  44. ncbi Chromosomal excision of TCRdelta chain genes is dispensable for alphabeta T cell lineage commitment
    Bernard Khor
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St Louis, MO 63110, USA
    Int Immunol 17:225-32. 2005
    ..However, alphabeta T cell development appears unperturbed in TCRalpha/delta(I/I) mice. Thus, excision of TCRdelta genes from the chromosome per se is not required for commitment of developing lymphocytes to the alphabeta T cell lineage...
  45. ncbi Alteration of T-cell receptor repertoires during thymic T-cell development
    T Matsutani
    Division of Immunology and Embryology, Department of Cell Biology, Tohoku University School of Medicine, Sendai, Japan
    Scand J Immunol 64:53-60. 2006
    ..We thus consider that pre-selection TCR repertoire in immature T cells could be determined by some genetic factors conserved among different strains...
  46. ncbi Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX
    H T Chen
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 290:1962-5. 2000
    ..Our results suggest that surveillance of T cell receptor recombination intermediates by NBS1 and gamma-H2AX may be important for preventing oncogenic translocations...
  47. ncbi Emergence of TCR alpha/beta V(D)J recombination and transcription during ontogeny of inbred mouse strains
    C M Junta
    Departamento de Genetica, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Brasil
    Mol Cell Biochem 187:67-72. 1998
    ..The transcriptions of these loci followed respective recombinations and we detected an early germline transcript before TCR beta locus recombination in the CBA strain...
  48. ncbi Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1
    R M Okamura
    Howard Hughes Medical Institute, Department of Microbiology, University of California, San Francisco 94143 0414, USA
    Immunity 8:11-20. 1998
    ..Together, these data show that LEF-1 and TCF-1 are redundant in the regulation of T cell differentiation and gene expression...
  49. ncbi Restricted T cell receptor repertoire for acetylcholine receptor in murine myasthenia gravis
    E Kraig
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio 78284, USA
    J Neuroimmunol 71:87-95. 1996
    ..The utilization of multiple T cell receptor V beta genes may contribute to the inability to inhibit EAMG by elimination of V beta 6+ T cells...
  50. ncbi p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes
    M A Bogue
    Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 10:553-65. 1996
    ..These results suggest that exposure to ionizing radiation facilitates a partial bypass of the scid defect, perhaps by inducing p53-dependent DNA damage response pathways...
  51. pmc A dominant-negative transgene defines a role for p56lck in thymopoiesis
    S D Levin
    Howard Hughes Medical Institute, University of Washington, Seattle 98195
    EMBO J 12:1671-80. 1993
    ..These results suggest that p56lck normally regulates T cell production by metering the replicative potential of immature thymoblasts...
  52. ncbi Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus
    R W Hendriks
    Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University Rotterdam, The Netherlands
    Eur J Immunol 29:1912-8. 1999
    ..We therefore propose that GATA-3 is required for the expansion of T cell progenitors, and for the control of subsequent proliferation steps, which alternate periods of TCR recombination in the thymus...
  53. ncbi Polymorphism within a TCRAV family influences the repertoire through class I/II restriction
    B C Sim
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 160:1204-11. 1998
    ....
  54. ncbi A novel type of aberrant T cell receptor alpha-chain gene rearrangement. Implications for allelic exclusion and the V-J recombination process
    I Hue
    Centre d Immunologie INSERM CNRS de Marseille Luminy, France
    J Immunol 144:4410-9. 1990
    ..In addition, in each T cell clone, alpha-rearrangements on homologous chromosomes were unevenly distributed over the J alpha region and shown to generally involve neighboring J alpha gene segments...
  55. ncbi TCR alpha-chain repertoire in pTalpha-deficient mice is diverse and developmentally regulated: implications for pre-TCR functions and TCRA gene rearrangement
    S Mancini
    Laboratoire d Immunochimie, Commissariat a l Energie Atomique Grenoble, Departement de Biologie Moleculaire et Structurale, Institut National de la Santé et de la Recherche Médicale Unit 238, Universite Joseph Fourier, Grenoble, France
    J Immunol 163:6053-9. 1999
    ....
  56. ncbi A NK1.1+ thymocyte-derived TCR beta-chain transgene promotes positive selection of thymic NK1.1+ alpha beta T cells
    C Viret
    Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 165:3004-14. 2000
    ....
  57. ncbi Clonal expanded TRA and TRB subfamily T cells in peripheral blood from patients with diffuse large B-cell lymphoma
    Huo Tan
    Centre of Oncology and Hematology, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510230, China
    Hematology 15:81-7. 2010
    ..In conclusion, the frequent and restricted clonal expansion alphabeta(+) T cells were thought to be the specific immune response to lymphoma-associated antigen...
  58. ncbi Positive and negative selection of T cells
    Timothy K Starr
    Center for Immunology and the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis 55455, USA
    Annu Rev Immunol 21:139-76. 2003
    ..We also discuss emerging data on the selection of regulatory T cells. Such cells require a high-affinity interaction with self-antigens, yet differentiate into regulatory cells instead of being eliminated...
  59. ncbi Systematic analysis of the combinatorial nature of epitopes recognized by TCR leads to identification of mimicry epitopes for glutamic acid decarboxylase 65-specific TCRs
    Yasushi Uemura
    Division of Immunogenetics, Department of Neuroscience and Immunology, Kumamoto University Graduate School of Medical Sciences, Kumamoto University School of Medicine, Japan
    J Immunol 170:947-60. 2003
    ..Our data demonstrate the importance of the combinatorial nature of amino acid residues of epitopes in molecular mimicry...
  60. pmc Invariant TCR rather than CD1d shapes the preferential activities of C-glycoside analogues against human versus murine invariant NKT cells
    Xiangming Li
    HIV and Malaria Vaccine Program, Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA
    J Immunol 183:4415-21. 2009
    ..Overall, the structural difference of invTCR appears to supersede those of CD1d molecule in shaping the strength of the biological activity of C-glycoside analogues...
  61. ncbi TCR V beta 8+ T cells prevent development of toxoplasmic encephalitis in BALB/c mice genetically resistant to the disease
    Hoil Kang
    Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 170:4254-9. 2003
    ..Thus, Vbeta8(+) T cells appear to play a crucial role in the genetic resistance of BALB/c mice against development of TE...
  62. ncbi T-cell receptor excisional circles, telomere length, proliferation and apoptosis in peripheral blood mononuclear cells of human immunodeficiency virus-infected individuals after 18 months of treatment induced viral suppression
    H Aladdin
    Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark
    Scand J Immunol 57:485-92. 2003
    ..The study demonstrated that HAART induces normal TREC levels in the CD4+ T-cell pool. However, the other perturbed functions in T cells indicate that immune reconstitution is incomplete and may need longer viral suppression...
  63. pmc The timing of TCR alpha expression critically influences T cell development and selection
    Troy A Baldwin
    Center for Immunology, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Exp Med 202:111-21. 2005
    ..Collectively, these data establish the importance of proper timing of TCR expression in thymic development and selection and emphasize the need to use models that most accurately reflect the physiologic process...
  64. ncbi Mouse autoreactive gamma/delta T cells. II. Molecular characterization of the T cell receptor
    A Ezquerra
    Biological Resources Branch, National Institute of Allergy and Infectious Diseases, National Instiutes of Health, Bethesda, MD 20892
    Eur J Immunol 22:491-8. 1992
    ....
  65. pmc T lymphocytes in giant cell arteritic lesions are polyclonal cells expressing alpha beta type antigen receptors and VLA-1 integrin receptors
    C Schaufelberger
    Gothenburg University, Department of Clinical Chemistry, Sahlgren s Hospital, Sweden
    Clin Exp Immunol 91:421-8. 1993
    ..This supports the hypothesis that GCA involves an inflammatory response during which polyclonal T cells adhere to arterial tissue components and accumulate in the developing lesions...
  66. ncbi Analysis of TCRalphabeta combinations used by simian immunodeficiency virus-specific CD8+ T cells in rhesus monkeys: implications for CTL immunodominance
    Atsuhiko Hasegawa
    Division of Immunology, Tulane National Primate Research Center, Tulane University Health Sciences Center, 18703 Three Rivers Road, Covington, LA 70433, USA
    J Immunol 178:3409-17. 2007
    ..These findings will aid in understanding immunodominance and designing new approaches to modulate CTL responses...
  67. ncbi TCR-alpha CDR3 loop audition regulates positive selection
    Cristina Ferreira
    Transplantation Biology Group, Department of Immunology, Imperial College, Hammersmith Hospital, Du Cane Road, London, United Kingdom
    J Immunol 177:2477-85. 2006
    ..Further, the two modes of selection favor alternate sets of AJ segments. We discuss the relevance of these findings to the imprint of self-MHC restriction and peripheral T cell activation...
  68. ncbi Multiple T-cell clones specific for the same foreign pMHC ligand can be generated from a single, ancestral TCR-VDJbeta precursor
    Janet L Maryanski
    INSERM U503, IFR 128 Biosciences Lyon Gerland, 21 Avenue Tony Garnier, 69365 Lyon Cedex 07, France
    Immunol Res 30:231-40. 2004
    ..An intriguing explanation of our findings would be that only a very limited repertoire of TCR alpha-chains is selected to pair with a given TCR beta-chain during T-cell development...
  69. ncbi The complementarity determining region 2 of BV8S2 (V beta 8.2) contributes to antigen recognition by rat invariant NKT cell TCR
    Elwira Pyz
    Institute for Virology and Immunobiology, Wurzburg University, Germany
    J Immunol 176:7447-55. 2006
    ..2) beta-chains. The results confirmed the need of syngeneic CD1d as restriction element for rat iNKT TCR and identified the CDR2 of BV8S2 as an essential site for ligand recognition by iNKT TCR...
  70. ncbi Lymphotoxin alpha 1 beta 2: a critical mediator in V alpha 14i NKT cell differentiation
    Ann Sophie Franki
    Laboratory of Pharmaceutical Biotechnology, Gent University, Belgium
    Mol Immunol 42:413-7. 2005
    ..Altogether, these observations underscore the unique developmental requirements of this particular lymphocyte subset...
  71. ncbi Scheduled kinetics of cell proliferation and phenotypic changes during immature thymocyte generation
    F Vasseur
    , Institut Necker, Paris, France
    Eur J Immunol 31:3038-47. 2001
    ..These data show that precursor thymocytes undergo two independent waves of expansion, and that the second wave is restricted to cells capable of pre-TCR expression...
  72. ncbi Involvement of the same region of the T cell antigen receptor in thymic selection and foreign peptide recognition
    J Kaye
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037
    J Immunol 148:3342-53. 1992
    ..The findings presented here are discussed in relation to the possible role of self-peptides in positive selection...
  73. ncbi Accessibility control of T cell receptor gene rearrangement in developing thymocytes. The TCR alpha/delta locus
    M S Krangel
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    Immunol Res 22:127-35. 2000
    ..Current work suggests that they may do so by functioning as regional modulators of histone acetylation...
  74. ncbi Alternative splicing and hypermutation of a nonproductively rearranged TCR alpha-chain in a T cell hybridoma
    B Marshall
    Institute of Molecular Medicine and Genetics, Program in Molecular Immunology, Medical College of Georgia, Augusta 30912 3175, USA
    J Immunol 162:871-7. 1999
    ..Evidence is presented for the presence of cDNA reverse transcripts of the TCR alpha-chain within the hybridoma, suggesting a role for reverse transcriptase in the generation of mutations...
  75. ncbi Superantigen-induced TCR alpha locus secondary rearrangement: role in tolerance induction
    Ching Yu Huang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 168:3259-65. 2002
    ..These results suggest that viral superantigens are capable of inducing peripheral TCR revision. Our findings thus provide a new perspective on pathogen-immune system interaction...
  76. ncbi Severe inclusion body beta-thalassaemia with haemolysis in a patient double heterozygous for beta(0)-thalassaemia and quadruplicated alpha-globin gene arrangement of the anti-4.2 type
    P Beris
    Division of Haematology, Geneva University Hospital, Switzerland
    Br J Haematol 105:1074-80. 1999
    ....
  77. ncbi Analysis of T cell receptor alpha-chain variable region (Valpha) usage and CDR3alpha of T cells infiltrated into lesions of psoriasis patients
    Ha Young Hwang
    Laboratory of Dermatology Immunology, Catholic Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, South Korea
    Mol Immunol 43:420-5. 2006
    ..The results in this study might provide the clue to define the characteristics of T cells associated with the pathogenesis of psoriasis...
  78. ncbi Two distinct mechanisms for the SCL gene activation in the t(1;14) translocation of T-cell leukemias
    O Bernard
    U301 INSERM CNRS, Institute de Genetique Moleculaire, France
    Genes Chromosomes Cancer 1:194-208. 1990
    ..Taken together, our data support the notion that the involvement of the SCL gene in the leukemogenic process may occur through overexpression of an apparently normal transcript (Kd cells) or expression of a truncated RNA (DU 528 cells)...
  79. ncbi A T cell receptor V alpha region selectively expressed in CD4+ cells
    S C Jameson
    Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037
    J Immunol 145:1324-31. 1990
    ..These data suggest that V alpha 11 can differentially influence the selection of T cells into the CD4+/CD8+ subsets...
  80. pmc Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes
    Bingye Han
    Department of Microbiology and Infectious Diseases, Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Clin Invest 115:1879-87. 2005
    ..These results illustrate the way in which incomplete deletion of autoreactive T cell populations of relatively high avidity can contribute to the development of pathogenic autoimmunity in the periphery...
  81. ncbi Characterization of the Japanese pufferfish (Takifugu rubripes) T-cell receptor alpha locus reveals a unique genomic organization
    K Wang
    Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Immunogenetics 53:31-42. 2001
    ..These conserved features suggest that the TCRA gene families in fish and mammals have evolved from a common ancestor...
  82. ncbi Expansion and hyperactivity of CD1d-restricted NKT cells during the progression of systemic lupus erythematosus in (New Zealand Black x New Zealand White)F1 mice
    Claire Forestier
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Immunol 175:763-70. 2005
    ....
  83. ncbi Invariant V alpha 14+ NKT cells participate in the early response to enteric Listeria monocytogenes infection
    Thomas Ranson
    Unité des Cytokines et Développement Lymphoide, Institut National de la Santé et de la Recherche Médicale Unité 668, Institut Pasteur, 25 rue du Docteur Roux, Cedex 15 Paris, France
    J Immunol 175:1137-44. 2005
    ..monocytogenes through amplification of IFN-gamma production, but are not essential for, nor capable of, mediating memory responses required to sterilize the host...
  84. pmc Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure
    Abbas Hawwari
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Exp Med 202:467-72. 2005
    ....
  85. pmc Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP
    C K Suzuki
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    J Cell Biol 114:189-205. 1991
    ..These data suggest that the intracellular fate of newly synthesized proteins stably associated with BiP can be regulated by Ca2+ levels in the ER...
  86. pmc Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks
    A Bhandoola
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 192:891-7. 2000
    ..It is likely that the unique ability of immature thymocytes to survive DNA-damaging intercalating agents reflects their tolerance of double-stranded DNA breaks that occur normally during antigen receptor gene rearrangements...
  87. pmc Human alpha beta and gamma delta thymocyte development: TCR gene rearrangements, intracellular TCR beta expression, and gamma delta developmental potential--differences between men and mice
    Michelle L Joachims
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Immunol 176:1543-52. 2006
    ..Aspects that differ from the mouse are the status of TCR gene rearrangements at the nonexpressed loci, the timing of beta selection, and maintenance of gammadelta potential through the early double positive stage of development...
  88. ncbi Gene expression profiling in mice with enforced Gata3 expression reveals putative targets of Gata3 in double positive thymocytes
    Jan Piet van Hamburg
    Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    Mol Immunol 46:3251-60. 2009
    ....
  89. ncbi Flexible stereospecific interactions and composition within nucleoprotein complexes assembled on the TCR alpha gene enhancer
    Beatriz Del Blanco
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Científicas Parque Tecnológico de Ciencias de la Salud, Armilla, Granada, Spain
    J Immunol 183:1871-83. 2009
    ..The possibility of assembly of distinct sets of proteins on Ealpha might represent a more flexible form of information processing during thymocyte development...
  90. pmc CTCF regulates cell cycle progression of alphabeta T cells in the thymus
    Helen Heath
    Department of Cell Biology and Genetics, Erasmus MC, Rotterdam, The Netherlands
    EMBO J 27:2839-50. 2008
    ..We propose that CTCF positively regulates cell growth in rapidly dividing thymocytes so that appropriate number of cells are generated before positive and negative selection in the thymus...
  91. pmc Aberrant extrathymic T cell receptor gene rearrangement in the small intestinal mucosa: a risk factor for coeliac disease?
    A Bas
    Department of Clinical Microbiology, Immunology, Umea University, Umea, Sweden
    Gut 58:189-95. 2009
    ..Gluten intake by patients with coeliac disease provokes a strong reaction by intestinal intraepithelial lymphocytes (IELs), which normalises on a gluten-free diet...
  92. ncbi A novel mouse model for invariant NKT cell study
    Hiroshi Wakao
    Environmental Biology, School of Medicine, Hokkaido University, Sapporo, Japan
    J Immunol 179:3888-95. 2007
    ..These mice will be useful for the study on the development of iNKT cells as well as on their functions in the immune system...
  93. ncbi V beta T cell repertoire of CD8+ splenocytes selected on nonpolymorphic MHC class I molecules
    D Laouini
    Laboratoire de Biologie Moléculaire du Gène, Institut National de la Santé et de la Recherche Médicale U277 Institut Pasteur, Paris, France
    J Immunol 165:6381-6. 2000
    ..This observation implies that BV diversity is positively correlated with the number of CD8(+) cells, even when the number of CD8(+) splenocytes is dramatically reduced (90% in the double knockout mice)...
  94. ncbi TCR beta chain that forms peptide-independent alloreactive TCR transfers reduced reactivity with irrelevant peptide/MHC complex
    Fabio R Santori
    Michael Heidelberger Division of Immunology, Department of Pathology and New York University Cancer Center, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 178:6109-14. 2007
    ..In addition, these findings demonstrate that reactivity to peptides is preferred over the reactivity to MHC during the formation of the TCR repertoire...
  95. ncbi NKT cells in the rat: organ-specific distribution of NK T cells expressing distinct V alpha 14 chains
    A Matsuura
    Sapporo Medical University, School of Medicine, Department of Pathology, Sapporo, Japan
    J Immunol 164:3140-8. 2000
    ..The implication of the molecular interaction between the structurally diverse invariant TCR alpha and CD1d/ligand complex in different organs is discussed...
  96. pmc Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression
    D Brändle
    Institute of Experimental Immunology, University of Zurich, Switzerland
    Proc Natl Acad Sci U S A 89:9529-33. 1992
    ..Our findings suggest that binding of the TCR to self MHC molecules during positive selection down-regulates RAG-1 transcription in cortical thymocytes and thereby prevents further TCR alpha-chain rearrangements...
  97. ncbi Identification of an aberrant type of rearrangement in the T-cell receptor alpha/delta locus in adult T-cell leukemia
    M Saitou
    Department of Materials and Biosystem Engineering, Faculty of Engineering, Toyama University, Japan
    J Hum Genet 46:706-11. 2001
    ..1-J40 rearrangement. These findings are the first direct demonstration that successive rearrangements with hybrid joints occur on the same chromosome in the human TCR alpha locus...
  98. ncbi MR1-restricted V alpha 19i mucosal-associated invariant T cells are innate T cells in the gut lamina propria that provide a rapid and diverse cytokine response
    Izumi Kawachi
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 176:1618-27. 2006
    ..These data strongly support the idea that MAIT cells contribute to the innate immune response in the gut mucosa...
  99. ncbi Analysis of T cell receptor variable regions and complementarity determining region 3 of infiltrating T lymphocytes in the liver of patients with chronic type B hepatitis
    Yasushi Maru
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Intervirology 46:277-88. 2003
    ..T cell receptor (TCR) variable regions and complementarity determining regions 3 (CDR3) of infiltrating T cells in the livers of patients with chronic hepatitis B were examined in detail...
  100. pmc Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development
    Amal Saidi
    Leibniz Institute for Age Research Fritz Lipmann Institute FLI, Beutenbergstrasse 11, 07743 Jena, Germany
    Mol Cell Biol 30:5572-81. 2010
    ..All together, these results demonstrate that Nbs1's functions in both repair of V(D)J-generated DSBs and proliferation are essential for T-cell development...
  101. pmc Role of the multiple T cell receptor (TCR)-zeta chain signaling motifs in selection of the T cell repertoire
    E W Shores
    Division of Hematologic Products, Food and Drug Administration, Bethesda, Maryland 20892, USA
    J Exp Med 185:893-900. 1997
    ..These results reveal a role for multiple TCR ITAMs in thymocyte selection and identify a function for TCR signal amplification in formation of the T cell repertoire...

Research Grants12

  1. Control Of Tcr Data And Tcr Alpha Rearrangement
    MICHAEL KRANGEL; Fiscal Year: 2005
    ..abstract_text> ..
  2. T CELL RESPONSE TO A PERIODONTAL PATHOGEN
    Ellen Kraig; Fiscal Year: 2002
    ..The long term goal is to develop and validate a model for evaluating host-parasite interactions, vaccine potency, and immune protection for periodontal diseases. ..
  3. A novel protein regulating thymocyte development
    NICHOLAS R GASCOIGNE; Fiscal Year: 2010
    ..This newly discovered protein appears to regulate these processes, thus this project will uncover how this novel protein functions. ..
  4. Molecular Interactions in the Aging Immunological Synapse
    NICHOLAS GASCOIGNE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  5. NOVEL APPROACH TO CHLAMYDIA VACCINE DEVELOPMENT
    Ellen Kraig; Fiscal Year: 2007
    ..trachomatis and to other intracellular pathogens. ..
  6. Leica TCSSP2RS two-photon microscope for in vivo imaging
    NICHOLAS GASCOIGNE; Fiscal Year: 2006
    ..Overall, this instrument will allow the user group to radically improve their ability to perform experiments on understanding the immune system in development and disease. [unreadable] [unreadable] [unreadable]..
  7. SOLUBLE T CELL RECEPTOR STUDIES ON MHC RESTRICTION
    NICHOLAS GASCOIGNE; Fiscal Year: 2006
    ..TCR dimerization will be investigated in solution, using biophysical methods including FRET, analytical ultracentrifugation and BIAcore. ..
  8. Real-time molecular interactions in tolerance induction
    NICHOLAS GASCOIGNE; Fiscal Year: 2003
    ..Conditions where naive T cells are tolerized in peripheral (pancreatic) lymph nodes or activated for diabetes will be analyzed. ..
  9. Cannabinoid Receptor Dynamics in T Cell Activation
    NICHOLAS GASCOIGNE; Fiscal Year: 2002
    ..We will express fluorescent CB2 in APC, to see how expression is affected by drug exposure and by interaction with T cells. ..
  10. EVOLUTIONARY MODELS OF THE IMMUNE SYSTEM
    Melvin Cohn; Fiscal Year: 2010
    ..The influx of mathematicians and computer modelers is clearly changing the way we analyze immune behavior. ..
  11. Mimic Peptides of HIV-1 Epitopes as Vaccines
    Darcy Wilson; Fiscal Year: 2005
    ..Ultimately, this peptide sequence information will be incorporated into a therapeutic/ prophylactic multi-epitope vaccine formulation based on multiple peptides, fusion proteins or DNA sequences in viral vectors. ..
  12. SELECTION OF T-CELL RECEPTOR V-ALPHA REGIONS
    NICHOLAS GASCOIGNE; Fiscal Year: 2009
    ....