Genomes and Genes
leukemic gene expression regulation
Summary: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in leukemia.
Publications214 found, 100 shown here
- Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemiaTeresa Palomero
Institute for Cancer Genetics, Columbia University, New York, New York 10032, USA
Nat Med 13:1203-10. 2007....
- Identification of glucocorticoid-response genes in children with acute lymphoblastic leukemiaStefan Schmidt
Tyrolean Cancer Research Institute, Innrain 66, A 6020 Innsbruck, Austria
Blood 107:2061-9. 2006....
- Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemiaGeorge Adrian Calin
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Proc Natl Acad Sci U S A 99:15524-9. 2002..Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority ( approximately 68%) of CLL cases...
- miR-15 and miR-16 induce apoptosis by targeting BCL2Amelia Cimmino
Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus OH 43210, USA
Proc Natl Acad Sci U S A 102:13944-9. 2005..BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors...
- High meningioma 1 (MN1) expression as a predictor for poor outcome in acute myeloid leukemia with normal cytogeneticsMichael Heuser
British Columbia Cancer Research Centre, 675 West 10th Ave, Vancouver, BC, Canada
Blood 108:3898-905. 2006..In conclusion, our data suggest MN1 overexpression as a new prognostic marker in AML with normal cytogenetics...
- Comprehensive genetic characterization of CLL: a study on 506 cases analysed with chromosome banding analysis, interphase FISH, IgV(H) status and immunophenotypingC Haferlach
MLL Munich Leukemia Laboratory, Munich, Germany
Leukemia 21:2442-51. 2007..Therefore, prospective clinical trials should evaluate the prognostic impact of newly available CBA data...
- Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cellsEsther Hulleman
Department of Pediatric Oncology and Hematology, Erasmus Medical Center Sophia Children s Hospital, University Medical Center, Rotterdam, The Netherlands
Blood 113:2014-21. 2009..Together, these findings indicate the importance of the glycolytic pathway in glucocorticoid resistance in ALL and suggest that targeting glycolysis is a viable strategy for modulating prednisolone resistance in ALL...
- CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironmentPiers E M Patten
Department of Haematological and Molecular Medicine, King s College London, Rayne Institute, London, USA
Blood 111:5173-81. 2008....
- Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1Bas J Wouters
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Blood 110:3706-14. 2007..A gene expression prediction signature allowed the detection of similar cases of leukemia in independent series of AML...
- MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemiaScott A Armstrong
Departments of Pediatric Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA
Nat Genet 30:41-7. 2002..Establishing that MLL is a unique entity is critical, as it mandates the examination of selectively expressed genes for urgently needed molecular targets...
- Expression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemiaJaewon Choi
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Ku, Seoul, South Korea 135 710
Blood 109:471-7. 2007..049). This study suggests that Livin expression is a novel prognostic marker in childhood ALL and thus needs to be incorporated into the patient stratification and treatment protocols...
- Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: a novel transgenic model for human Ph1-positive leukemiasH Honda
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Blood 91:2067-75. 1998....
- Genomewide identification of prednisolone-responsive genes in acute lymphoblastic leukemia cellsWim J E Tissing
Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
Blood 109:3929-35. 2007..Biologic characterization of these genes and pathways might elucidate the action of glucocorticoids in ALL cells, possibly suggesting causes of glucocorticoid resistance and new potential targets for therapy...
- HERG K+ channel expression in CD34+/CD38-/CD123(high) cells and primary leukemia cells and analysis of its regulation in leukemia cellsHuiyu Li
Center for Stem Cell Research and Application, Institute of Hematology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiegang Avenue, 430022 Wuhan, China
Int J Hematol 87:387-92. 2008..These data provide evidence for the oncogenic potential of HERG K+ channels and it may be a novel, potential pharmacological target for leukemia therapy in the future...
- MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemiaMojca Jongen-Lavrencic
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Blood 111:5078-85. 2008..MicroRNA expression apparently bears specific relationships to the heterogeneous pathobiology of AML. Distinctive microRNA signatures appear of potential value in the clinical diagnosis of AML...
- Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoproteinFrancesco Fazi
Department of Histology and Medical Embryology, University La Sapienza, Rome, 00161, Italy
Cancer Cell 12:457-66. 2007..Here, we identify an additional action for a leukemia fusion protein linking the epigenetic silencing of a microRNA locus to the differentiation block of leukemia...
- MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1Ramiro Garzon
Department of Medicine, Ohio State University, Columbus, 43210, USA
Blood 113:6411-8. 2009....
- Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expressionMaría J Bueno
Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncologicas CNIO, E 28029 Madrid, Spain
Cancer Cell 13:496-506. 2008..Thus, miR-203 functions as a tumor suppressor, and re-expression of this microRNA might have therapeutic benefits in specific hematopoietic malignancies...
- Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemiaValter Gattei
Clinical and Experimental Onco Hematology Unit, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientifico Aviano, Italy
Blood 111:865-73. 2008..95; P=.002) cases. These findings support the introduction of CD49d detection in routine prognostic assessment of CLL patients, and suggest both pathogenetic and therapeutic implications for CD49d expression in CLL...
- Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemiaClemens Grabher
Department of Pediatric Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Rev Cancer 6:347-59. 2006..The recent discovery of novel activating mutations in NOTCH1 in more than 50% of human T-ALL samples has made it clear that Notch 1 is far more important in human T-ALL pathogenesis than previously suspected...
- The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15)Takeshi Taketani
Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, 113 8655, Japan
Cancer Res 62:33-7. 2002....
- Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemiaY Liu
Radiumhemmet, Karolinska Hospital, Stockholm, Sweden
Oncogene 15:2463-73. 1997..We conclude that the Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis...
- High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimatedSanne Lugthart
Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
Blood 111:4329-37. 2008..001 and event-free survival [EFS]: P = .002). We argue that EVI1/ME quantitative expression analysis should be implemented in the molecular diagnostic procedures of AML...
- Complexity of miR-223 regulation by CEBPA in human AMLMarianne Eyholzer
Institute of Medical Oncology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland
Leuk Res 34:672-6. 2010..Our results suggest that miR-223 suppression in AML is caused by impaired miR-223 upstream factors...
- Karyotype-specific microRNA signature in chronic lymphocytic leukemiaRosa Visone
Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
Blood 114:3872-9. 2009..Thus, the use of the microRNA-based classifications may yield clinically useful biomarkers of tumor behavior in CLL...
- Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemiaA Migliazza
Institute of Cancer Genetics, Columbia University, New York, New York 10032, USA
Blood 97:2098-104. 2001..However, haplo-insufficiency of one of the identified genes may contribute to tumorigenesis. (Blood. 2001;97:2098-2104)..
- Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemiaAdolfo A Ferrando
Department of Pediatric Oncology, Dana Farber Cancer Institute Harvard School of Public Health, 44 Binney Street, Mayer 630, Boston 02115, MA, USA
Lancet 363:535-6. 2004..Furthermore, our findings lead to questions about whether stem-cell transplantation in first remission is necessary for effective treatment of patients in the low-risk subgroup of patients with TLX1 oncogene expression...
- Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformationSabina Chiaretti
Department of Medical Oncology and Biostatistical Science, Dana Farber Cancer Institute, Boston, MA 02115, USA
Clin Cancer Res 11:7209-19. 2005..To characterize gene expression signatures in acute lymphocytic leukemia (ALL) cells associated with known genotypic abnormalities in adult patients...
- Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AMLSahar Barjesteh van Waalwijk van Doorn-Khosrovani
Institute of Hematology, Erasmus Medical Centre, Rotterdam, The Netherlands
Hematol J 4:31-40. 2003..By including this newly developed PCR assay, we define a subgroup of good-risk patients within the heterogeneous intermediate-risk group of AML...
- Chronic myelogenous leukemia molecular signatureMichal Oskar Nowicki
Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA
Oncogene 22:3952-63. 2003..Altogether, this work provides a large body of information regarding gene expression profiles associated with CML and also represents a source of potential targets for CML therapeutics...
- Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemiaJose Roman-Gomez
Department of Hematology, Hospital Reina Sofia, Cordoba, Spain
Blood 109:3462-9. 2007..001) and overall survival (28% versus 61% respectively, P = .001). Our results indicate a role of abnormal Wnt signaling in ALL and establish a group of patients with a significantly worse prognosis (methylated group)...
- Identification of genomic classifiers that distinguish induction failure in T-lineage acute lymphoblastic leukemia: a report from the Children's Oncology GroupStuart S Winter
Department of Pediatrics, The University of New Mexico Health Sciences Center, Albuquerque, NM 87131 5311, USA
Blood 110:1429-38. 2007..Genetic profiling may identify T-ALL patients who are likely to fail induction and for whom alternate treatment strategies might be beneficial...
- High expression of bfl-1 contributes to the apoptosis resistant phenotype in B-cell chronic lymphocytic leukemiaAlejo A Morales
Microbiology and Tumor Biology Center, Karolinska Institutet, Stockholm, Sweden
Int J Cancer 113:730-7. 2005..05). We conclude that bfl-1 may be an important regulator of B-CLL apoptosis, which could contribute to disease progression and resistance to chemotherapy, and as such represent a future potential therapeutic target...
- Concurrent methylation of promoters from tumor associated genes predicts outcome in acute myeloid leukemiaCorine J Hess
Department of Haematology, VU University Medical Center, Amsterdam, The Netherlands
Leuk Lymphoma 49:1132-41. 2008..In addition, ESR1 methylation may reflect a biological pathway that leads to hypermethylation of multiple genes, which is reflected by methylation of IGSF4 and/or CDKN2B/p15...
- Oncogenic transcription factors in the human acute leukemiasA T Look
Department of Experimental Oncology, St Jude Children s Research Hospital, Memphis, TN 38105, USA 38163, USA
Science 278:1059-64. 1997..The insights gained from studies of translocation-generated oncogenes and their protein products should hasten the development of highly specific, and hence less toxic, forms of leukemia therapy...
- Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemiaH Mabuchi
Kimmel Cancer Center, Thomas Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA
Cancer Res 61:2870-7. 2001....
- The immunophenotype of acute myeloid leukemia: is there a relationship with prognosis?Kylie D Mason
Department of Diagnostic Haematology, Royal Melbourne Hospital, Grattan St, Parkville, Vic, Australia
Blood Rev 20:71-82. 2006..Further analysis with the inclusion of novel antibodies and the combination of multiple antibodies to create further subgroups such as the panmyeloid phenotype will continue to enhance knowledge in this area...
- Gene expression profiles in a panel of childhood leukemia cell lines mirror critical features of the diseaseUrsula R Kees
Telethon Institute for Child Health Research, The University of Western Australia, Perth, Australia and National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA
Mol Cancer Ther 2:671-7. 2003..Importantly, the panel of lines displayed the critical genetic features identified in clinically important acute lymphoblastic leukemia subtypes in childhood leukemia patients...
- Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre studyRiccardo Bomben
Clinical and Experimental Onco Haematology Unit, Centro di Riferimento Oncologico, I R C C S, Aviano PN, Italy
Br J Haematol 144:492-506. 2009..Altogether, our analysis identified additional molecular and clinical features for CLL expressing stereotyped BCR...
- Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1Nicolas Pineault
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver V5Z 1L3, Canada
Mol Cell Biol 24:1907-17. 2004..Our results support a model in which many if not all Hox genes can be leukemogenic and point to striking functional overlap not previously appreciated, presumably reflecting common regulated pathways...
- A virus-encoded telomerase RNA promotes malignant T cell lymphomagenesisSascha Trapp
Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
J Exp Med 203:1307-17. 2006..We concluded that vTR plays a critical role in MDV-induced T cell lymphomagenesis. Furthermore, our results provide the first description of tumor-promoting effects of TR in a natural virus-host infection model...
- Differential expression of survivin in bone marrow cells from patients with acute lymphocytic leukemia and chronic lymphocytic leukemiaYasunori Nakagawa
Department of Pathology and Immunology, Aging and Developmental Sciences, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Leuk Res 28:487-94. 2004....
- CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitorsT Palomero
Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA
Leukemia 20:1279-87. 2006....
- The role of HOX genes in malignant myeloid diseaseElizabeth A Eklund
The Feinberg School at Northwestern University and Jesse Brown VHA Medical Center, Chicago, Illinois 60611, USA
Curr Opin Hematol 14:85-9. 2007..The purpose of this review is to outline recent progress in understanding the role that dysregulation of HOX-gene expression plays in the pathogenesis of myeloid leukemogenesis...
- Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemiaSusan M O'Brien
M D Anderson Cancer Center, 1515 Holcombe Blvd, Box 428, Houston, TX 77030 7305, USA
J Clin Oncol 23:7697-702. 2005..To determine the maximum-tolerated dose (MTD), efficacy, safety, and pharmacokinetics of oblimersen sodium in patients with advanced chronic lymphocytic leukemia (CLL)...
- Pattern robustness of diagnostic gene expression signatures in leukemiaAlexander Kohlmann
Laboratory for Leukemia Diagnostics, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
Genes Chromosomes Cancer 42:299-307. 2005....
- New insights into MLL gene rearranged acute leukemias using gene expression profiling: shared pathways, lineage commitment, and partner genesA Kohlmann
Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, Ludwig Maximilians University, 81377 Munich, Germany
Leukemia 19:953-64. 2005..Taken together, the identified molecular expression pattern of MLL fusion gene samples and biological networks revealed new insights into the aberrant transcriptional program in 11q23/MLL leukemias...
- The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapySusan P Whitman
Department of Internal Medicine, Division of Hematology Oncology, The Ohio State University, Columbus, OH 43210, USA
Blood 106:345-52. 2005....
- Hox regulation of normal and leukemic hematopoietic stem cellsCarolina Abramovich
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
Curr Opin Hematol 12:210-6. 2005....
- HS1 protein is differentially expressed in chronic lymphocytic leukemia patient subsets with good or poor prognosesCristina Scielzo
Department of Oncology, Universita Vita e Salute San Raffaele, Milan, Italy
J Clin Invest 115:1644-50. 2005..These data indicate a central role for antigen stimulation in CLL and suggest a new therapeutic target for patients with aggressive disease...
- Variation of LEF-1 mRNA expression in low-grade B-cell non-Hodgkin's lymphomaDenise Howe
Leukaemia Research Laboratory, Taunton and Somerset NHS Trust, Musgrove Park Hospital, Taunton, Somerset TA1 5DA, UK
Leuk Res 30:29-32. 2006..This suggests that there exist key differences in the activity of the Wnt/beta-catenin pathway between low-grade B-cell malignancies...
- Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemiaMaria Ilaria Del Principe
Cattedra di Ematologia, Universita Tor Vergata, Ospedale S Eugenio, Via Fiume Giallo, 430 MA, 00144 Roma, Rome, Italy
Blood 108:853-61. 2006..On this line, we recommend and are also interested in conducting a prospective randomized trial of early intervention versus observation for ZAP-70(+) patients...
- CLLU1 expression analysis adds prognostic information to risk prediction in chronic lymphocytic leukemiaPär Josefsson
The Leukemia Laboratory, Department of Hematology, Rigshospitalet and University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
Blood 109:4973-9. 2007..Only CLLU1 expression and IgV(H) mutational status had independent predictive power. Thus, analysis of CLLU1 expression is highly applicable in risk prediction in CLL for patients of an age eligible for risk stratification...
- CD7 expression predicts poor disease free survival and post-remission survival in patients with acute myeloid leukemia and normal karyotypeHong Chang
Department of Laboratory Hematology, Princess Margaret Hospital, University Health Network, University of Toronto, 610 University Avenue, 4 320, Toronto, Ont, Canada M5G 2M9
Leuk Res 31:157-62. 2007..003 and P=0.0157, respectively) and shorter OS (P</=0.001 and P=0.007, respectively). Multivariate analysis of age, WBC, CD34, HLA-DR and CD7 showed that CD7 expression was an independent risk factor for DFS (P=0.01) and PRS (P=0.02)...
- Biology, clinical relevance, and molecularly targeted therapy in acute leukemia with FLT3 mutationHitoshi Kiyoi
Department of Infectious Diseases, Nagoya University Graduate School of Medicine, Nagoya, Japan
Int J Hematol 83:301-8. 2006....
- Pediatric acute lymphoblastic leukemia (ALL) gene expression signatures classify an independent cohort of adult ALL patientsA Kohlmann
Laboratory for Leukemia Diagnostics, Department of Internal Medicine III, Ludwig Maximilians University, Munich, Germany
Leukemia 18:63-71. 2004..As such, previously reported gene expression patterns identified by microarray technology are validated and confirmed on truly independent leukemia patient samples...
- Expression and prognostic significance of different mRNA 5'-end variants of the oncogene EVI1 in 266 patients with de novo AML: EVI1 and MDS1/EVI1 overexpression both predict short remission durationKatja Haas
Department of Medical Genetics, Medical University of Vienna, Vienna, Austria
Genes Chromosomes Cancer 47:288-98. 2008..This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat...
- Repression of the BH3-only molecule PMAIP1/Noxa impairs glucocorticoid sensitivity of acute lymphoblastic leukemia cellsChristian Ploner
Division Molecular Pathophysiology, Biocenter, Medical University of Innsbruck, Fritz Pregl Strasse 3, 6020, Innsbruck, Austria
Apoptosis 14:821-8. 2009..Interfering with the anti-apoptotic component of the GC response might contribute to improved therapeutic approaches and circumvention of resistance to this therapy...
- CD38 at the junction between prognostic marker and therapeutic targetSilvia Deaglio
Department of Genetics, Laboratory of Immunogenetics, Biology and Biochemistry and CERMS, Via Santena 19, 10126 Torino, Italy
Trends Mol Med 14:210-8. 2008..The use of reagents specifically blocking the molecule might provide a new approach for interfering with deleterious growth circuits, therefore increasing the susceptibility of leukemic cells to conventional chemotherapy...
- The role of microRNAs in normal hematopoiesis and hematopoietic malignanciesJ Kluiver
Department of Pathology and Laboratory Medicine, Section Pathology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Leukemia 20:1931-6. 2006..In this review, we report on the biological relevance of miRNAs for the differentiation of normal hematopoietic cells and on the contribution of deregulated miRNA expression in their malignant counterparts...
- Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progressionS Fears
Section of Hematology, Oncology Department of Medicine, University of Chicago, Chicago, IL 60637, USA
Cancer Genet Cytogenet 135:110-9. 2002..TCL1 expression was correlated with TEL expression by reintroducing TEL into AT-2 cells and demonstrating that those cells expressing TEL at high levels showed a decreased expression of endogenous TCL1...
- Classification of pediatric acute lymphoblastic leukemia by gene expression profilingMary E Ross
Department of Hematology Oncology, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
Blood 102:2951-9. 2003....
- Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletionBelinda Austen
Cancer Research UK Institute for Cancer Studies, University of Birmingham, United Kingdom
J Clin Oncol 25:5448-57. 2007..Our aim was to determine if CLL tumors with a chromosome 11q deletion might be divided into two subgroups based on the status of the remaining ATM allele...
- Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemiaMuhammad Mansha
Division Molecular Pathophysiology, Biocenter, Medical University of Innsbruck, Innsbruck 6020, Austria
Leuk Res 34:529-34. 2010..Although SLA is a prominent GC response gene, it does not seem to contribute to the anti-leukemic effects of GC...
- Epigenetic analysis of childhood acute lymphoblastic leukemiaThomas L Dunwell
Institute of Biomedical Research, Medical School, University of Birmingham, Edgbaston, Birmingham, UK
Epigenetics 4:185-93. 2009..The identification of frequently methylated genes showing cancer specific methylation will be useful in developing early cancer detection screens and for targeted epigenetic therapies...
- NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15)T Nakamura
PRESTO, Japan Science and Technology Corp, Tokyo, Japan The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
Blood 94:741-7. 1999..These findings suggest that constitutive expression and alteration of the transcriptional activity of the PMX1 homeodomain protein may be critical for myeloid leukemogenesis...
- Glucocorticoid receptor heterozygosity combined with lack of receptor auto-induction causes glucocorticoid resistance in Jurkat acute lymphoblastic leukemia cellsS Riml
Division of Molecular Pathophysiology, Institute of Pathophysiology, University of Innsbruck Medical School, Fritz Pregl Str 3, A 6020 Innsbruck, Austria
Cell Death Differ 11:S65-72. 2004..Absent GR auto-induction could not be restored by transgenic GR and, hence, was not caused by reduced basal GR levels. Thus, inactivation of one GR gene results in haploinsufficiency if associated with lack of GR auto-induction...
- Elevated expression of the AF1q gene, an MLL fusion partner, is an independent adverse prognostic factor in pediatric acute myeloid leukemiaWilliam Tse
Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington School of Medicine, Seattle, USA
Blood 104:3058-63. 2004..01). AF1q expression may correlate with clinical outcome in pediatric AML, although it is not clear if AF1q is simply a marker of a more primitive phenotype or contributes directly to leukemogenesis...
- Prognostic significance of, and gene and microRNA expression signatures associated with, CEBPA mutations in cytogenetically normal acute myeloid leukemia with high-risk molecular features: a Cancer and Leukemia Group B StudyGuido Marcucci
Division of Hematology and Oncology, Department of Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
J Clin Oncol 26:5078-87. 2008....
- Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemiaLiguang Chen
Division of Hematology Oncology, Department of Medicine, University of California, San Diego for the CLL Research Consortium, San Diego, CA, USA
Blood 100:4609-14. 2002....
- Hox expression in AML identifies a distinct subset of patients with intermediate cytogeneticsJ Roche
CNRS UMR 6187, Universite de Poitiers, 40 Av du Recteur Pineau, Poitiers, Cedex, France
Leukemia 18:1059-63. 2004..The apparent global upregulation of HOX expression could be due to growth-factor signaling or, alternatively, these patterns may reflect a particular stage of differentiation of the leukemic cells...
- Survival of leukemic B cells promoted by engagement of the antigen receptorA Bernal
Immunology Program, Weill Graduate School of Medical Sciences of Cornell University, and Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
Blood 98:3050-7. 2001....
- Altered glucose metabolism in childhood pre-B acute lymphoblastic leukaemiaJ M Boag
Division of Children s Leukaemia and Cancer Research, Telethon Institute for Child Health Research, Perth, Western Australia, Australia
Leukemia 20:1731-7. 2006..The finding offers new options for targeted therapy for ALL patients...
- BCR-ABL down-regulates the DNA repair protein DNA-PKcsE Deutsch
, Institut Gustave Roussy, Villejuif, France
Blood 97:2084-90. 2001..The down-regulation of DNA-PKcs was reversible in CD34(+) CML cells suggesting that this approach might offer a novel and powerful therapeutic strategy in this disease, especially to delay the blast crisis. (Blood. 2001;97:2084-2090)..
- Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemiaJ Rainer
Tyrolean Cancer Research Institute, Innsbruck, Austria
Leukemia 23:746-52. 2009..Thus, the observed complex changes in miRNA/mirtron expression during GC treatment might contribute to the anti-leukemic GC effects in a cell context-dependent manner...
- BCR-ABL(T315I) transcript disappearance in an imatinib-resistant CML patient treated with homoharringtonine: a new therapeutic challenge?L Legros
Leukemia 21:2204-6. 2007
- Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotidesKarl J Aichberger
Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, AKH Wien, Waehringer Guertel 18 20, A 1097 Vienna, Austria
Blood 105:3303-11. 2005..Moreover, the mcl-1 ASO was found to synergize with imatinib in producing growth inhibition in these cells. Together, our data identify MCL-1 as a BCR/ABL-dependent survival factor and interesting target in CML...
- Expression of the leukemic prognostic marker CD7 is linked to epigenetic modifications in chronic myeloid leukemiaSally L Rogers
Terry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada
Mol Cancer 9:41. 2010..However, little is known about the mechanisms that underlie the variable expression of these genes in the leukemic cells...
- A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) through 15-deoxy-Delta 12, 14 prostaglandin J2 productionHiroo Hasegawa
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Blood 110:1664-74. 2007..These results indicate that 15d-PGJ(2) sensitizes TRAIL-resistant cells to TRAIL in a PPAR gamma-independent manner and that the use of 15d-PGJ(2) or its inducers, such as FCB, is a new strategy for cancer therapy...
- Characterization of ABL1 expression in adult T-cell acute lymphoblastic leukemia by oligonucleotide array analysisSabina Chiaretti
Division of Hematology, Department of Cellular Biotechnologies and Hematology, University La Sapienza, Rome, Italy
Haematologica 92:619-26. 2007..We sought to evaluate whether T-ALL patients with overexpression of ABL showed a peculiar gene expression pattern and were characterized by having specific rearrangements...
- Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL responseLaurence Lagneaux
Experimental Hematology, Bordet Institute, ULB, Brussels, Belgium
Exp Hematol 35:1527-37. 2007..The effects of valproic acid (VPA), an antiepileptic drug with histone deacetylase inhibitory activity, on mononuclear cells isolated from 40 CLL patients were evaluated...
- Effect of ionizing radiation on cellular procoagulability and co-ordinated gene alterationsPetra Goldin-Lang
Department of Cardiology and Pneumology, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
Haematologica 92:1091-8. 2007..Our study examined whether IR induced tissue factor (TF) expression and procoagulability. We further investigated coordinated gene alterations associated with TF upregulation in the myelomonocytic leukemia THP-1 cells...
- Deregulation of the Wilms' tumour gene 1 protein (WT1) by BCR/ABL1 mediates resistance to imatinib in human leukaemia cellsE Svensson
Division of Hematology and Transfusion Medicine, Faculty of Medicine, Lund University, Lund, Sweden
Leukemia 21:2485-94. 2007..Our data demonstrate that WT1 expression is induced by oncogenic signalling from BCR/ABL1 and that WT1 contributes to resistance against apoptosis induced by imatinib...
- Constitutive Fms-like tyrosine kinase 3 activation results in specific changes in gene expression in myeloid leukaemic cellsKyu Tae Kim
Department of Oncology, Johns Hopkins University School of Medicine, Bethesda, MD, USA
Br J Haematol 138:603-15. 2007..The alterations of the gene expression profiles in these cells help to further elucidate the mechanisms of FLT3-mediated leukaemogenesis...
- Transcriptional dysregulation mediated by RUNX1-RUNX1T1 in normal human progenitor cells and in acute myeloid leukaemiaA Tonks
Department of Haematology, School of Medicine, Cardiff University, Cardiff, UK
Leukemia 21:2495-505. 2007..These data provide the most comprehensive and pertinent assessment of the effect of RUNX1-RUNX1T1 on gene expression and demonstrate the highly context-dependent effects of this fusion gene...
- The histone deacetylase inhibitor AN-9 has selective toxicity to acute leukemia and drug-resistant primary leukemia and cancer cell linesAyse Batova
Division of Pediatric Hematology Oncology, Department of Pediatrics, Medical Center, University of California San Diego, 200 West Arbor Drive, San Diego, CA 92103 8447, USA
Blood 100:3319-24. 2002..Collectively, our results suggest that AN-9 is a selective agent for hematopoietic malignancies that can circumvent the mechanisms of chemoresistance limiting most conventional chemotherapy...
- The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapyY Ge
Developmental Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA
Leukemia 22:521-9. 2008....
- Topoisomerase IIbeta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistanceSuzan McNamara
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, Segal Cancer Center, 3755 Chemin de la Cote Ste Catherine, Montreal, Quebec, Canada
Mol Cell Biol 28:2066-77. 2008..Our results identify a novel mechanism of resistance in APL and provide further insight to the role of TopoIIbeta in gene regulation and differentiation...
- Altered gene expression in busulfan-resistant human myeloid leukemiaBenigno C Valdez
Department of Stem Cell Transplantation and Cellular Therapy, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, United States
Leuk Res 32:1684-97. 2008....
- Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3Bob Argiropoulos
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
Exp Hematol 36:845-59. 2008..MEIS1, a HOX cofactor, collaborates with multiple HOX and NUP98-HOX fusion proteins to accelerate the onset of acute myeloid leukemia (AML) through largely unknown molecular mechanisms...
- Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemiasC G Mullighan
Department of Pathology, St Jude Children s Research Hospital, Memphis, TN, USA
Leukemia 21:2000-9. 2007..These findings suggest that mutated NPM1 leads to dysregulated HOX expression via a different mechanism than MLL rearrangement...
- The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activationSung A Lee
Department of Radiation Medicine, Georgetown University Medical Center, Washington, DC 20057 1482, USA
J Biol Chem 282:15271-83. 2007..Taken together, our data suggest that sangivamycin induces mitochondria-mediated apoptotic cell death of MCF7/ADR cells via activation of JNK in a protein kinase Cdelta-dependent manner...
- Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain familyS Fears
Department of Molecular Genetics and Cellular Biology, The University of Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 93:1642-7. 1996..These results are important in view of the fact that EVI1 and MDS1 are involved in leukemia associated with chromosomal translocation breakpoints in the region between these genes...
- Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutationsMasao Mizuki
Department of Medicine, Hematology Oncology, University of Munster, Germany
Blood 101:3164-73. 2003..The identification of the transcriptional program induced by ITD mutations should ease the development of specific therapies...
- ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual diseaseP F Erickson
Division of Medical Oncology, University of Colorado Medical School, Denver 80262, USA
Blood 88:1813-23. 1996..Also, because ETO would not be exclusively expressed as part of chimeric AML1/ETO in leukemic patients, its presence cannot be used to monitor t(8;21) AML residual disease...
- DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1K Kannan
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
Oncogene 20:3449-55. 2001..The proapoptotic genes induced only in LTR6 cells like Apaf-1, Sumo-1 and gelsolin among others may suggest a possible explanation for apoptosis in LTR6 cells...
- Expression of sorcin predicts poor outcome in acute myeloid leukemiaYaohong Tan
State Key Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300020, China
Leuk Res 27:125-31. 2003..Our results indicated that sorcin might be one of the factors that contributes to drug resistance of AML patients...
- Beta-hydroxyisovalerylshikonin induces apoptosis in human leukemia cells by inhibiting the activity of a polo-like kinase 1 (PLK1)Yutaka Masuda
Laboratory of Biological Chemistry, School of Pharmaceutical Sciences, Showa University, Tokyo 142 8555, Japan
Oncogene 22:1012-23. 2003..These results suggest that suppression of the activity of PLK1 via inhibition of tyrosine kinase activity by beta-HIVS might play a critical role in the induction of apoptosis...
- In vitro susceptibility to TRAIL-induced apoptosis of acute leukemia cells in the context of TRAIL receptor gene expression and constitutive NF-kappa B activityC Wuchter
Department of Hematology, Oncology, and Tumor Immunology, Robert Rossle Clinic, Charite, Humboldt University of Berlin, Germany
Leukemia 15:921-8. 2001..The observed sensitization of leukemic cells to TRAIL by doxorubicin in vitro indicates that TRAIL should be further evaluated as to its possible role as an in vivo cotherapeutic in acute leukemia...
- Multidrug resistance modulators PSC 833 and CsA show differential capacity to induce apoptosis in lymphoid leukemia cell lines independently of their MDR phenotypeEloisi C Lopes
Department of Immunology, School of Pharmacy and Biochemistry, University of Buenos Aires UBA IDEHU CONICET, Junin 956 4 piso, 1113, Buenos Aires, Argentina
Leuk Res 27:413-23. 2003..1 microg ml(-1)) or by direct impact on the cells through induction of apoptosis (1 microg ml(-1)), in the latter case through a mechanism that might act independent of the Bcl-2 family proteins...
- Chromatin remodeling gene SMARCA5 is dysregulated in primitive hematopoietic cells of acute leukemiaT Stopka
Institute of Hematology and Blood Transfusion and Department of Pathophysiology, First Medical Faculty, Charles University, Prague, Czech Republic
Leukemia 14:1247-52. 2000..In CD34+ AML progenitors over-expression of SMARCA5 may thus dysregulate the genetic program required for normal differentiation...
- Examination of imatinib mesylate resistance in CMLVivian Oehler; Fiscal Year: 2008..The gene expression pattern of the relapsed sample will be compared with the corresponding diagnostic sample. We hypothesize that the evolution of a previously undetected clone is the mechanism of relapse. ..
- AFB1 AND P53 CARCINOGENESIS IN HBSAG TRANSGENIC MICEStewart Sell; Fiscal Year: 2002..These studies should lead to an understanding of how each of these risk factors affect hepatocyte proliferation and how these effects contribute to AFB1 hepatocarcinogenesis. ..
- A NOVEL VECTOR FOR VACCINATION AGAINST HEPETITIS C VIRUSNikolaus Osterrieder; Fiscal Year: 2006..The tests will include ELISPOT and CTL assays in the context of a human class I allele using HLA-A2.1 transgenic mice. ..
- Novel Functions for Telomerase Enzyme Complex in VivoSteven Artandi; Fiscal Year: 2005..Through analysis of a conditional knockout mouse, we will determine the role of endogenous telomerase in cells in culture and in stern/progenitor compartments in vivo. ..
- TARGETED MANIPULATION OF STEM CELLS FOR AIDS THERAPYDavid T Scadden; Fiscal Year: 2010..Success of this project will provide both in depth understanding of key regulatory pathways for adult HSC and create targeted approaches to manipulate stem cell self-renewal for therapeutic purposes. ..
- Characterization of the 11q13 Amplicon in Oral CancerSusanne Gollin; Fiscal Year: 2006..The results of this study may lead to targeted methods for prevention, early detection, therapy, and/or eradication of cells harboring gene amplification. ..
- Retinoic Acid Regulated Cell Differentiation: BLR1 RcptrAndrew Yen; Fiscal Year: 2005..It has the implication that the ultimate effects of RA can be governed by relevant growth factors signaling through their cognate receptors. ..
- Prognosis in childhood ALLURSULA KEES; Fiscal Year: 2006....
- Development of SL-101, An Immunotoxin that Targets Cancer Stem CellsMalcolm Moore; Fiscal Year: 2006..This Phase I STTR grant will cover the development of SL-101 through key phases of pre-clinical development. [unreadable] [unreadable] [unreadable]..
- Human TNFa-Induced Pre-B Cell Bone Marrow EmigrantsMARC LEVESQUE; Fiscal Year: 2007..We will also determine whether anti-TNFa therapy is associated with reductions in peripheral populations of TNFa- induced pre-B cell bone marrow emigrants in RA patients. [unreadable] [unreadable] [unreadable]..
- 2007 Cell Biology of Megakaryocytes and Platelets GRCKenneth Kaushansky; Fiscal Year: 2007..e. speakers, discussion leaders, postdoctoral fellows, students, etc.) at this important scientific meeting. [unreadable] [unreadable] [unreadable]..
- Control of lymphomagenesis by ATM through ROS, mTOR and PP2A signalingMingshan Yan; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- STEM CELLS AND AGINGStewart Sell; Fiscal Year: 2008..The results of these experiments should provide critical proof for one of the most important hypothetical properties of adult stem cells. ..
- STEM CELLS AND HEPATOCARCINOGENESISStewart Sell; Fiscal Year: 2009..Knowledge of the cellular origin of cancer is critical for understanding how cancer evolves and for developing prevention strategies. ..
- HoxA10 Function During Myeloid DifferentiationElizabeth Eklund; Fiscal Year: 2006..These investigations will identify the molecular mechanisms of target gene regulation by HoxA10, which may suggest a role for HoxA10 in differentiation block in myeloid leukemia. ..
- GROWTH FACTORS IN NORMAL AND NEOPLASTIC HEMATOPOIESISKenneth Kaushansky; Fiscal Year: 2006....
- TOPOISOMERASES IN RETINOID INDUCED DIFFERENTIATIONAndrew Yen; Fiscal Year: 2003..Andrew Yen, who brings expertise on the molecular and cellular biology of retinoic acid-induced myeloid differentiation. ..
- POST TRANSCRIPTIONAL CONTROL OF THE HUMAN N MYC GENEWilliam Carroll; Fiscal Year: 2002....
- Phase II Trial of Thalidomide in Primary AmyloidosisAngela Dispenzieri; Fiscal Year: 2002..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
- TELOMERE DYSFUNCTION, GENOMIC INSTABILITY AND CANCERSteven Artandi; Fiscal Year: 2005..Transplantation experiments using this model will reveal if the effect on tumor biology is a cell autonomous one. ..
- FACTORS INFLUENCING STEM CELL AND PLATELET PRODUCTIONMalcolm Moore; Fiscal Year: 2002..e., adult populations acquiring features of neonatal cells, or whether there is a tendency for "immortalized" cells to undergo neoplastic transformation. ..
- VZV BACs: New Tools for Pathogenesis ResearchNikolaus Osterrieder; Fiscal Year: 2005..B-scid/beige mice, and infected MeWo or MeWo-9 cells will be used to inoculate the grafts. Virus replication in the implants will be examined by virus titrations, real-time PCR, histopathology and immunohistochemistry. ..
- Cell biology of megakaryocytes and platelets 2005Kenneth Kaushansky; Fiscal Year: 2005..This application is a request for partial funds to support the attendance of speakers and discussion leaders, and selected postdoctoral fellows and students at this important new meeting. ..
- Prevention of Chronic Lymphocytic Leukemia (CLL)MARC LEVESQUE; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- GENES INVOLVED IN AIDS LYMPHOMAGENESISMichael Teitell; Fiscal Year: 2002..Genes with significant involvement in the etiology and/or progression of lymphomagenesis, or those with reproducible in vitro biochemical effects, will be further characterized by molecular methods. ..
- FUSION GENES IN LEUKEMIA--DETERMINING SIGNIFICANCEMignon Loh; Fiscal Year: 2003..abstract_text> ..
- Chemical Genomics Approach to Leukemia DifferentiationKimberly Stegmaier; Fiscal Year: 2007..These candidate compounds, as well as an improved understanding of myeloid leukemia differentiation, should help direct us to potential therapeutic agents for AML. ..
- BOSTON AIDS MALIGNANCY CONSORTIUMDavid Scadden; Fiscal Year: 2004..Furthering the efforts of the BAMC within the national consortium is the focus of this proposal. ..
- DIFFERENTIATION OF BLOOD STEM CELLS INTO LIVER CELLSStewart Sell; Fiscal Year: 2005..If this project is successful, it would overcome a major hurdle in the possible use of hepatic stem cells for treatment of liver failure or ex vivo gene therapy. ..
- HEPTOCYTE PROLIFERATION AND AFLATOXIN METABOLISMStewart Sell; Fiscal Year: 2004..the effect Of HBV associated injury and AFB I hepatocarcinogensis in these mice. In Specific Aim 3, the effect of HBV associated injury and AFB1 hepatocarcinogenesis in these mice will be examined. ..
- ICSBP Function During Myeloid DifferentiationElizabeth Eklund; Fiscal Year: 2006..These studies will determine if ICSBP tyrosine phosphorylation is necessary for myeloid differentiation and leukemia suppression, providing a unique model to dissect early events in the evolution of myeloid malignancy. ..
- FLT3 GENOTYPES IN ACUTE MYELOID LEUKEMIASusan Whitman; Fiscal Year: 2006..abstract_text> ..
- FLUORESCENCE ACTIVATED CELL SORTERAndrew Yen; Fiscal Year: 2004..The instrument requested is a Dako-Cytomation basic MoFlo plus a UV-vis, vis, and HeNe laser to provide independent UV, vis/488, and red excitation. ..
- Ras Pathway Mutations in Human LeukemiaMignon Loh; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Bcr-Abl RNA levels to monitor STI571 leukemia therapyRichard Press; Fiscal Year: 2004..abstract_text> ..
- Phase I Clinical Trials of Anti-Cancer AgentsFrancis Giles; Fiscal Year: 2007..abstract_text> ..
- Hedgehog signaling as a novel regulator of hematopoiesisIannis Aifantis; Fiscal Year: 2007..We will complement these experiments with the study of novel Hh activating mouse mutants in which we will define the exact role of the Gli factors in the regulation of mammalian lymphopoiesis and hematopoiesis. ..
- Examination of FLT3 Mutations in Acute Myeloid LeukemiaDerek Stirewalt; Fiscal Year: 2006..Together, the research proposal and educational program provide Dc Stirewalt with the skills to become an independent clinical investigator. ..