Genomes and Genes
Summary: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Publications468 found, 100 shown here
- A new mathematical model for relative quantification in real-time RT-PCRM W Pfaffl
Institute of Physiology, FML Weihenstephan, Center of Life and Food Sciences, Technical University of Munich, Germany
Nucleic Acids Res 29:e45. 2001..High accuracy and reproducibility (<2.5% variation) were reached in LightCycler PCR using the established mathematical model...
- MicroRNAs: genomics, biogenesis, mechanism, and functionDavid P Bartel
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Cell 116:281-97. 2004..Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes...
- Statistical significance for genomewide studiesJohn D Storey
Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 100:9440-5. 2003..Our approach avoids a flood of false positive results, while offering a more liberal criterion than what has been used in genome scans for linkage...
- Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCRMichael W Pfaffl
Institute of Physiology, FML Weihenstephan, Center of Life and Food Sciences, Technical University of Munich, Germany
Nucleic Acids Res 30:e36. 2002..The latest software version of REST and examples for the correct use can be downloaded at http://www.wzw.tum.de/gene-quantification/...
- Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot projectEwan Birney
Nature 447:799-816. 2007..Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function...
- DNA methylation patterns and epigenetic memoryAdrian Bird
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
Genes Dev 16:6-21. 2002
- Translating the histone codeT Jenuwein
Research Institute of Molecular Pathology IMP at the Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
Science 293:1074-80. 2001....
- RNA-Seq: a revolutionary tool for transcriptomicsZhong Wang
Department of Molecular, Cellular and Developmental Biology, Yale University, 219 Prospect Street, New Haven, Connecticut 06520, USA
Nat Rev Genet 10:57-63. 2009..This article describes the RNA-Seq approach, the challenges associated with its application, and the advances made so far in characterizing several eukaryote transcriptomes...
- ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular contextAdam A Margolin
Department of Biomedical Informatics, Columbia University, New York, NY 10032, USA
BMC Bioinformatics 7:S7. 2006..This method uses an information theoretic approach to eliminate the majority of indirect interactions inferred by co-expression methods...
- Bidirectional promoters generate pervasive transcription in yeastZhenyu Xu
European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Nature 457:1033-7. 2009....
- Stochastic mRNA synthesis in mammalian cellsArjun Raj
Courant Institute of Mathematical Sciences, New York University, New York, New York, USA
PLoS Biol 4:e309. 2006..These results demonstrate that gene expression in mammalian cells is subject to large, intrinsically random fluctuations and raise questions about how cells are able to function in the face of such noise...
- Transcriptome changes for Arabidopsis in response to salt, osmotic, and cold stressJoel A Kreps
Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, California 92121, USA
Plant Physiol 130:2129-41. 2002..Although these results identify hundreds of potentially important transcriptome changes, the biochemical functions of many stress-regulated genes remain unknown...
- Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cellsAlexander Marson
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Cell 134:521-33. 2008..These data reveal how key ES cell transcription factors promote the ES cell miRNA expression program and integrate miRNAs into the regulatory circuitry controlling ES cell identity...
- Identification of c-MYC as a target of the APC pathwayT C He
Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA
Science 281:1509-12. 1998..These results provide a molecular framework for understanding the previously enigmatic overexpression of c-MYC in colorectal cancers...
- Widespread bidirectional promoters are the major source of cryptic transcripts in yeastHelen Neil
Institut Pasteur, Unité de Génétique des Interactions Macromoléculaires, CNRS, URA2171, 75015 Paris, France
Nature 457:1038-42. 2009....
- The economics of ribosome biosynthesis in yeastJ R Warner
Dept of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, Bronx, NY 10461, USA
Trends Biochem Sci 24:437-40. 1999..This is entrusted to a number of signal transduction pathways that can abruptly induce or silence the ribosomal genes, leading to major implications for the expression of other genes as well...
- Genome-wide maps of chromatin state in pluripotent and lineage-committed cellsTarjei S Mikkelsen
Broad Institute of Harvard and MIT, Cambridge, Massachusetts 02142, USA
Nature 448:553-60. 2007..This study provides a framework for the application of comprehensive chromatin profiling towards characterization of diverse mammalian cell populations...
- Stat3 as an oncogeneJ F Bromberg
Laboratory of Molecular Cell Biology, The Rockefeller University, New York, New York 10021 6399, USA
Cell 98:295-303. 1999..Thus, the activated Stat3 molecule by itself can mediate cellular transformation and the experiments focus attention on the importance of constitutive Stat3 activation in human tumors...
- Convergence of Wnt, beta-catenin, and cadherin pathwaysW James Nelson
Department of Molecular and Cellular Physiology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Science 303:1483-7. 2004..Here, we assemble evidence of possible interrelations between Wnt and other growth factor signaling, beta-catenin functions, and cadherin-mediated adhesion...
- TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotesV Matys
BIOBASE GmbH, Halchtersche Strasse 33, D 38304 Wolfenbuttel, Germany
Nucleic Acids Res 34:D108-10. 2006..The here described public releases, TRANSFAC 7.0 and TRANSCompel 7.0, are accessible under http://www.gene-regulation.com/pub/databases.html...
- Shared principles in NF-kappaB signalingMatthew S Hayden
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Cell 132:344-62. 2008..Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-kappaB, and we aim to generate a more unified view of NF-kappaB regulation...
- The transcriptional landscape of the yeast genome defined by RNA sequencingUgrappa Nagalakshmi
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
Science 320:1344-9. 2008..We also found unexpected 3'-end heterogeneity and the presence of many overlapping genes. These results indicate that the yeast transcriptome is more complex than previously appreciated...
- CpG islands in vertebrate genomesM Gardiner-Garden
Kanematsu Laboratories, Royal Prince Alfred Hospital, Camperdown N S W, Australia
J Mol Biol 196:261-82. 1987..Possible functions of CpG islands in transcriptional and post-transcriptional regulation of gene expression were discussed, and were related to theories for the maintenance of CpG islands as "methylation-free zones" in germline DNA...
- Active genes are tri-methylated at K4 of histone H3Helena Santos-Rosa
Wellcome Trust Cancer Research UK Institute and Department of Pathology, Tennis Court Road, Cambridge, CB2 1QR, UK
Nature 419:407-11. 2002..These findings establish the concept of methyl status as a determinant for gene activity and thus extend considerably the complexity of histone modifications...
- Protein modification by SUMOErica S Johnson
Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Annu Rev Biochem 73:355-82. 2004..This review discusses our current understanding of how SUMO conjugation is controlled, as well as the roles of SUMO in a number of biological processes...
- Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1Z Wu
Dana Farber Cancer Institute, and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 98:115-24. 1999..These data elucidate a pathway that directly links external physiological stimuli to the regulation of mitochondrial biogenesis and function...
- FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcriptionMathieu Lupien
Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute and Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Cell 132:958-70. 2008..FoxA1 translates this epigenetic signature into changes in chromatin structure thereby establishing lineage-specific transcriptional enhancers and programs...
- Defining the epithelial stem cell niche in skinTudorita Tumbar
Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, Rockefeller University, New York, NY 10021, USA
Science 303:359-63. 2004..Many of the >100 messenger RNAs preferentially expressed in the niche encode surface receptors and secreted proteins, enabling LRCs to signal and respond to their environment...
- Genome-wide identification and testing of superior reference genes for transcript normalization in ArabidopsisTomasz Czechowski
Max Planck Institute of Molecular Plant Physiology, Potsdam, Germany
Plant Physiol 139:5-17. 2005..The developed PCR primers or hybridization probes for the novel reference genes will enable better normalization and quantification of transcript levels in Arabidopsis in the future...
- CPC: assess the protein-coding potential of transcripts using sequence features and support vector machineLei Kong
Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, PR China
Nucleic Acids Res 35:W345-9. 2007....
- MicroRNA genes are transcribed by RNA polymerase IIYoontae Lee
Institute of Molecular Biology and Genetics and School of Biological Science, Seoul National University, Seoul, Korea
EMBO J 23:4051-60. 2004..These data indicate that pol II is the main, if not the only, RNA polymerase for miRNA gene transcription. Our study offers a basis for understanding the structure and regulation of miRNA genes...
- RNA exosome depletion reveals transcription upstream of active human promotersPascal Preker
Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology, C F Møllers Alle, Building 1130, Aarhus University, Denmark
Science 322:1851-4. 2008..We propose that PROMPT transcription is a common characteristic of RNA polymerase II (RNAPII) transcribed genes with a possible regulatory potential...
- Coordinated transcription of key pathways in the mouse by the circadian clockSatchidananda Panda
The Genomics Institute of the Novartis Research Foundation, San Diego, California 92121, USA
Cell 109:307-20. 2002..Importantly, rate-limiting steps in these various pathways were key sites of circadian control, highlighting the fundamental role that circadian clocks play in cellular and organismal physiology...
- Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profilingJoanna C Betts
Respiratory Pathogens, GlaxoSmithKline, Stevenage, Herts, UK
Mol Microbiol 43:717-31. 2002..Thus, we have generated a model with which we can search for agents active against persistent M. tuberculosis and revealed a number of potential targets expressed under these conditions...
- Noise in protein expression scales with natural protein abundanceArren Bar-Even
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
Nat Genet 38:636-43. 2006....
- Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controlsR J Kaufman
Department of Biological Chemistry and Howard Hughes Medical Institute, The University of Michigan Medical Center, Ann Arbor, Michigan 48109 0650 USA
Genes Dev 13:1211-33. 1999
- Specificity and versatility in tgf-beta signaling through SmadsXin Hua Feng
Department of Molecular and Cellular Biology, Biology of Inflammation Center, Baylor College of Medicine, Houston, Texas 77030, USA
Annu Rev Cell Dev Biol 21:659-93. 2005..We review the molecular basis for the specificity and versatility of signaling by the many ligands through this conceptually simple signal transduction mechanism...
- Systematic functional analysis of the Caenorhabditis elegans genome using RNAiRavi S Kamath
Wellcome Trust Cancer Research UK Institute and Department of Genetics, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
Nature 421:231-7. 2003..Our resulting data set and reusable RNAi library of 16,757 bacterial clones will facilitate systematic analyses of the connections among gene sequence, chromosomal location and gene function in C. elegans...
- Rapid, accurate, computational discovery of Rho-independent transcription terminators illuminates their relationship to DNA uptakeCarleton L Kingsford
Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA
Genome Biol 8:R22. 2007..Previous computational methods to predict Rho-independent terminators have been slow or limited in the organisms they consider...
- Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibresJiandie Lin
Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 418:797-801. 2002..These data indicate that PGC-1 alpha is a principal factor regulating muscle fibre type determination...
- Nature, nurture, or chance: stochastic gene expression and its consequencesArjun Raj
Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 135:216-26. 2008..These situations include the stress response, metabolism, development, the cell cycle, circadian rhythms, and aging...
- A gene atlas of the mouse and human protein-encoding transcriptomesAndrew I Su
The Genomics Institute of the Novartis Research Foundation, 10675 John J Hopkins Drive, San Diego, CA 92121, USA
Proc Natl Acad Sci U S A 101:6062-7. 2004..We describe hundreds of regions of correlated transcription and show that some are subject to both tissue and parental allele-specific expression, suggesting a link between spatial expression and imprinting...
- Controlling the elongation phase of transcription with P-TEFbB Matija Peterlin
Department of Medicine, Microbiology and Immunology, Rosalind Russell Medical Research Center, University of California, San Francisco, San Francisco, California 94143, USA
Mol Cell 23:297-305. 2006..Phylogenetic analyses of the components of the human elongation control machinery indicate that the number of mechanisms utilized to regulate P-TEFb function increased as organisms developed more complex developmental patterns...
- Functionality or transcriptional noise? Evidence for selection within long noncoding RNAsJasmina Ponjavic
MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
Genome Res 17:556-65. 2007..2%). These macroRNAs, taken together, thus possess the imprint of purifying selection, thereby indicating their functionality. Our findings should now provide an incentive for the experimental investigation of these macroRNAs' functions...
- Epithelial-mesenchymal transitions in development and pathologiesJean Paul Thiery
Unite Mixte de Recherche 144, Centre National Recherche Scientifique, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
Curr Opin Cell Biol 15:740-6. 2003..Current studies further emphasise the critical importance of EMT and provide a better molecular and functional definition of mesenchymal cells and how they emerged >500 million years ago as a key event in evolution...
- The TetR family of transcriptional repressorsJuan L Ramos
Department of Plant Biochemistry and Molecular and Cellular Biology, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, Granada, Spain
Microbiol Mol Biol Rev 69:326-56. 2005..Information related to the TetR family of regulators has been updated in a database that can be accessed at www.bactregulators.org...
- Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complexX Nan
Institute of Cell and Molecular Biology, University of Edinburgh, UK
Nature 393:386-9. 1998..The data suggest that two global mechanisms of gene regulation, DNA methylation and histone deacetylation, can be linked by MeCP2...
- The Toll and Imd pathways are the major regulators of the immune response in DrosophilaEnnio De Gregorio
Centre de Genetique Moleculaire, CNRS, F 91198 Gif sur Yvette, France
EMBO J 21:2568-79. 2002..Interestingly, we observed that some Drosophila immune-responsive genes are located in gene clusters, which often are transcriptionally co-regulated...
- RNA polymerase is poised for activation across the genomeGinger W Muse
Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Nat Genet 39:1507-11. 2007..This finding indicates a role for regulation of polymerase elongation in the transcriptional responses to dynamic environmental and developmental cues...
- Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cellsH Niwa
Centre for Genome Research, The University of Edinburgh, King s Buildings, Edinburgh, UK
Nat Genet 24:372-6. 2000....
- Genome-wide mapping of in vivo protein-DNA interactionsDavid S Johnson
Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305 5120, USA
Science 316:1497-502. 2007..96] and statistical confidence (P <10(-4)), properties that were important for inferring new candidate interactions. These include key transcription factors in the gene network that regulates pancreatic islet cell development...
- Novel small RNA-encoding genes in the intergenic regions of Escherichia coliL Argaman
Department of Molecular Genetics and Biotechnology, The Hebrew University Hadassah Medical School, 91120, Jerusalem, Israel
Curr Biol 11:941-50. 2001..Thus, in spite of the rising recognition that such RNAs may play key roles in bacterial physiology, many of the small RNAs known to date were discovered fortuitously...
- Mammalian SIRT1 represses forkhead transcription factorsMaria Carla Motta
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 116:551-63. 2004..We speculate how down-regulating these two classes of damage-responsive mammalian factors may favor long lifespan under certain environmental conditions, such as calorie restriction...
- The complex language of chromatin regulation during transcriptionShelley L Berger
The Wistar Institute, 3601 Spruce Street, Room 201, Philadelphia, Pennsylvania 19104, USA
Nature 447:407-12. 2007..Although such modifications were initially thought to be a simple code, a more likely model is of a sophisticated, nuanced chromatin 'language' in which different combinations of basic building blocks yield dynamic functional outcomes...
- Transcription regulation through promoter-proximal pausing of RNA polymerase IILeighton J Core
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
Science 319:1791-2. 2008..This rate-limiting step occurs after recruitment and initiation of RNA polymerase II at a gene promoter. This stage in early elongation appears to be an important and broadly used target of gene regulation...
- Regulation of p53 stability by Mdm2M H Kubbutat
ABL Basic Research Program, NCI FCRDC, Frederick, Maryland 21702 1201, USA
Nature 387:299-303. 1997..Furthermore, mechanisms regulating the Mdm2-induced degradation of p53 may play a role in controlling the extent and duration of the p53 response...
- Transcriptional regulation of nanog by OCT4 and SOX2David J Rodda
Stem Cell and Developmental Biology and Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672
J Biol Chem 280:24731-7. 2005..These studies extend the understanding of the pluripotent genetic regulatory network within which the Sox2-Oct4 complex are at the top of the regulatory hierarchy...
- Functions of site-specific histone acetylation and deacetylationMona D Shahbazian
Department of Biological Chemistry, Geffen School of Medicine and the Molecular Biology Institute, University of California, Los Angeles, California 90095, USA
Annu Rev Biochem 76:75-100. 2007..Determining how these enzymes create distinct acetylation patterns and regulate the functional outcome is an important challenge...
- The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcriptionGilles Gaudray
Laboratoire Infections Retrovirales et Signalisation Cellulaire, CNRS UM I UMR 5121, Institut de Biologie, 4 Boulevard Henri IV, 34060 Montpellier, France
J Virol 76:12813-22. 2002..Moreover, the characterization of a minus-strand gene protein encoded by HTLV-1 has never been reported until now...
- Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicingRobert J Sims
Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA
Mol Cell 28:665-76. 2007..These findings suggest that methylated H3K4 serves to facilitate the competency of pre-mRNA maturation through the bridging of spliceosomal components to H3K4me3 via CHD1...
- Cyclical DNA methylation of a transcriptionally active promoterRaphaël Métivier
Universite de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu, 35042 Rennes Cedex, France
Nature 452:45-50. 2008..Cyclical changes in the methylation status of promoter CpGs may thus represent a critical event in transcriptional achievement...
- Dissecting the regulatory circuitry of a eukaryotic genomeF C Holstege
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Cell 95:717-28. 1998....
- Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylaseS Imai
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
Nature 403:795-800. 2000..These findings provide a molecular framework of NAD-dependent histone deacetylation that connects metabolism, genomic silencing and ageing in yeast and, perhaps, in higher eukaryotes...
- Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcriptionAdam Siddiqui-Jain
College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 99:11593-8. 2002..Furthermore, we establish the principle that c-MYC transcription can be controlled by ligand-mediated G-quadruplex stabilization...
- A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosomeC J Brown
Department of Genetics, Stanford University School of Medicine, California 94305
Nature 349:38-44. 1991..This gene, called XIST (for Xi-specific transcripts), is a candidate for a gene either involved in or uniquely influenced by the process of X inactivation...
- XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryosM Molenaar
Department of Immunology University Hospital, Utrecht The Netherlands
Cell 86:391-9. 1996..We propose that signaling by beta-catenin involves complex formation with XTcf-3, followed by nuclear translocation and activation of specific XTcf-3 target genes...
- Genesis: cluster analysis of microarray dataAlexander Sturn
Institute of Biomedical Engineering, Graz University of Technology, Krenngasse 37, 8010 Graz, Austria
Bioinformatics 18:207-8. 2002..Additionally, mapping of gene expression data onto chromosomal sequences was implemented to enhance promoter analysis and investigation of transcriptional control mechanisms...
- Single-RNA counting reveals alternative modes of gene expression in yeastDaniel Zenklusen
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Nat Struct Mol Biol 15:1263-71. 2008..These data directly demonstrate the existence of multiple expression modes used to modulate the transcriptome...
- Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcriptionMichael J Carrozza
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
Cell 123:581-92. 2005..This erases transcription elongation-associated acetylation to suppress intragenic transcription initiation...
- An oestrogen-receptor-alpha-bound human chromatin interactomeMelissa J Fullwood
Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore 138672
Nature 462:58-64. 2009..We propose that chromatin interactions constitute a primary mechanism for regulating transcription in mammalian genomes...
- Global analysis of mRNA decay and abundance in Escherichia coli at single-gene resolution using two-color fluorescent DNA microarraysJonathan A Bernstein
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 99:9697-702. 2002..Our results identify previously unsuspected features of mRNA decay at a global level and also indicate that generalizations about decay derived from the study of individual gene transcripts may have limited applicability...
- Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal EnvironmentDirk Schnappinger
Department of Microbiology and Immunology, Cornell University, 1300 York Avenue, New York, NY 10021, USA
J Exp Med 198:693-704. 2003..The microbial transcriptome thus served as a bioprobe of the MTB phagosomal environment, showing it to be nitrosative, oxidative, functionally hypoxic, carbohydrate poor, and capable of perturbing the pathogen's cell envelope...
- Specific expression of long noncoding RNAs in the mouse brainTim R Mercer
Australian Research Council Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD 4072, Australia
Proc Natl Acad Sci U S A 105:716-21. 2008..Our results show that the majority of ncRNAs are expressed in the brain and provide strong evidence that the majority of processed transcripts with no protein-coding capacity function intrinsically as RNAs...
- The coregulator exchange in transcriptional functions of nuclear receptorsC K Glass
Department of Cellular and Molecular Medicine, Department of Medicine, University of California, San Diego, La Jolla, California 92093 0651 USA
Genes Dev 14:121-41. 2000
- A chromatin landmark and transcription initiation at most promoters in human cellsMatthew G Guenther
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Cell 130:77-88. 2007..These observations extend to differentiated cells, suggesting that transcription initiation at most genes is a general phenomenon in human cells...
- Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemiaGeorge Adrian Calin
Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Proc Natl Acad Sci U S A 99:15524-9. 2002..Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority ( approximately 68%) of CLL cases...
- Signaling to NF-kappaBMatthew S Hayden
Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Genes Dev 18:2195-224. 2004..In this review, we provide an overview of established NF-kappaB signaling pathways with focus on the current state of research into the mechanisms that regulate IKK activation and NF-kappaB transcriptional activity...
- Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcriptionDaniel Zilberman
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
Nat Genet 39:61-9. 2007..Our results indicate that genic transcription and DNA methylation are closely interwoven processes...
- Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signalingK Lin
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, USA
Nat Genet 28:139-45. 2001..Together these findings reveal unexpected complexity in the DAF-16-dependent pathways that regulate aging...
- A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibilityMark P Keller
Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53076, USA
Genome Res 18:706-16. 2008....
- RegulonDB (version 6.0): gene regulation model of Escherichia coli K-12 beyond transcription, active (experimental) annotated promoters and Textpresso navigationSocorro Gama-Castro
Program of Computational Genomics, Centro de Ciencias Genomicas, Universidad Nacional Autonoma de Mexico, A P 565 A, Cuernavaca, Morelos 62100, Mexico
Nucleic Acids Res 36:D120-4. 2008..The data can be accessed through overviews of correlations about gene regulation. RegulonDB associated original literature, together with more than 4000 curation notes, can now be searched with the Textpresso text mining engine...
- Two strategies for gene regulation by promoter nucleosomesItay Tirosh
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
Genome Res 18:1084-91. 2008..Analysis of nucleosome positioning in human promoters reproduces the main observations. Our results suggest two distinct strategies for gene regulation by chromatin, which are selectively employed by different genes...
- Cracking the RNA polymerase II CTD codeSylvain Egloff
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
Trends Genet 24:280-8. 2008..How and when is the code written and read? How does it contribute to transcription and coordinate RNA processing?..
- The highways and byways of mRNA decayNicole L Garneau
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
Nat Rev Mol Cell Biol 8:113-26. 2007..In this article, we discuss some of the mechanisms that are used by the cell to mediate and regulate this intriguing process...
- Replication fork stalling at natural impedimentsEkaterina V Mirkin
Department of Biology, Tufts University, Medford, MA 02155, USA
Microbiol Mol Biol Rev 71:13-35. 2007..This review describes the mechanisms and consequences of replication stalling at various natural impediments, with an emphasis on the role of replication stalling in genomic instability...
- Multiple sigma subunits and the partitioning of bacterial transcription spaceTanja M Gruber
Department of Microbiology and Immunology, University of California, Genentech Hall, 600 16th St, San Francisco, San Francisco, California 94143, USA
Annu Rev Microbiol 57:441-66. 2003..We use the sigma repertoire of Escherichia coli, Bacillus subtilis, Streptomyces coelicolor, and cyanobacteria to illustrate the different strategies utilized to organize transcriptional space using multiple sigma factors...
- Antisense RNA stabilization induces transcriptional gene silencing via histone deacetylation in S. cerevisiaeJurgi Camblong
Department of Cell Biology, Sciences III, University of Geneva, 30 quai E Ansermet, 1211 Geneva 4, Switzerland
Cell 131:706-17. 2007....
- The Listeria transcriptional landscape from saprophytism to virulenceAlejandro Toledo-Arana
Institut Pasteur, Unité des Interactions Bactéries Cellules, F 75015 Paris, France
Nature 459:950-6. 2009..Together, our data unravel successive and coordinated global transcriptional changes during infection and point to previously unknown regulatory mechanisms in bacteria...
- hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylaseH Vaziri
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
Cell 107:149-59. 2001..In contrast, expression of a catalytically inactive hSir2 protein potentiates p53-dependent apoptosis and radiosensitivity. We propose that hSir2 is involved in the regulation of p53 function via deacetylation...
- Stochastic gene expression in a single cellMichael B Elowitz
Laboratory of Cancer Biology, Center for Studies in Physics and Biology, Rockefeller University, New York, NY 10021, USA
Science 297:1183-6. 2002..These results establish a quantitative foundation for modeling noise in genetic networks and reveal how low intracellular copy numbers of molecules can fundamentally limit the precision of gene regulation...
- Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegansColeen T Murphy
Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143 2200, USA
Nature 424:277-83. 2003....
- Androgen receptor in prostate cancerCynthia A Heinlein
George Whipple Laboratory for Cancer Research, Department of Pathology, University of Rochester, Rochester, NY 14642, USA
Endocr Rev 25:276-308. 2004..The inhibition of AR activity through mechanisms in addition to androgen ablation, such as modulation of signal transduction pathways, may delay prostate cancer progression...
- The transcriptional landscape of the mammalian genomeP Carninci
Science 309:1559-63. 2005..The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development...
- Control of developmental regulators by Polycomb in human embryonic stem cellsTong Ihn Lee
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Cell 125:301-13. 2006..These results indicate that PRC2 occupies a special set of developmental genes in ES cells that must be repressed to maintain pluripotency and that are poised for activation during ES cell differentiation...
- A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growthQianben Wang
Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
Mol Cell 27:380-92. 2007..These collaborating factors, together with AR, form a regulatory hierarchy that governs androgen-dependent gene expression and prostate cancer growth and offer potential new opportunities for therapeutic intervention...
- Progression through the RNA polymerase II CTD cycleStephen Buratowski
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
Mol Cell 36:541-6. 2009..Recent papers help to explain how the changes in CTD phosphorylation pattern are linked to the progression from initiation through elongation to termination...
- Somatic mosaicism in neuronal precursor cells mediated by L1 retrotranspositionAlysson R Muotri
Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Nature 435:903-10. 2005..Our data therefore indicate that neuronal genomes might not be static, but some might be mosaic because of de novo L1 retrotransposition events...
- Genomic DNA methylation: the mark and its mediatorsRobert J Klose
Wellcome Trust Centre for Cell Biology, University of Edinburgh, Michael Swann Building, Mayfield Road, Edinburgh EH9 3JR, UK
Trends Biochem Sci 31:89-97. 2006..Recent studies have illuminated the role of DNA methylation in controlling gene expression and have strengthened its links with histone modification and chromatin remodelling...
- Global transcription in pluripotent embryonic stem cellsSol Efroni
National Cancer Institute Center for Bioinformatics, National Institutes of Health, Rockville, MD 20852, USA
Cell Stem Cell 2:437-47. 2008..We propose that global transcription is a hallmark of pluripotent ESCs, contributing to their plasticity, and that lineage specification is driven by reduction of the transcribed portion of the genome...
- The role of DNA methylation in mammalian epigeneticsP A Jones
USC Norris Comprehensive Cancer Center, Departments of Biochemistry and Molecular Biology, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, MS 8302L, Los Angeles, CA 90089 9181, USA
Science 293:1068-70. 2001....
- TREX is a conserved complex coupling transcription with messenger RNA exportKatja Strasser
BZH, University of Heidelberg, Im Neuenheimer Feld 328, D 69120 Heidelberg, Germany
Nature 417:304-8. 2002..Our data indicate that the TREX complex has a conserved role in coupling transcription to mRNA export...
Research Grants120 found, 100 shown here
- Genetic variation and regulatory networks: Mechanisms and complexityDANA PE ER; Fiscal Year: 2009..These tools will be made publicly available, including a friendly graphical user interface and visualization. ..
- Personalized Clinical Diagnostics and Beyond: Integrated Ring Resonator ArraysRyan Bailey; Fiscal Year: 2009..This technology promises to broadly impact the landscape of the biomedical sciences, both meeting the clinical diagnostic challenges of today and pioneering the paradigm-shifting discoveries of tomorrow. ..
- Transcription factors regulating sensory gene expression and pain pathwaysEric E Turner; Fiscal Year: 2011..Together these studies will significantly advance our understanding of the molecular regulation of pain receptor pathways, which may form the basis for future pain treatments. ..
- Lauren Endres; Fiscal Year: 2014..Overall, these findings will form the basis of future studies into Abh8 regulation during the DDR. ..
- SHAOCHUNG VICTOR HSIA; Fiscal Year: 2016..The long-term goal is to identify the regulatory mechanisms to assist in the development of novel therapeutic protocols for better treatments. ..
- Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductaseSTEPHEN WILLIAM TUTTLE; Fiscal Year: 2010..However, curcumin has been effective in tumors, such as colon and HNC, where direct access to the drug is possible. The primary aim of this study is to develop curcumin as a chemotherapeutic and radiation sensitizer for treating HNC.. ..
- Sogol Mostoufi-Moab; Fiscal Year: 2016....
- Yun Fai Chris Lau; Fiscal Year: 2014..This project will shed important insights on how the Y-oncogene and X-tumor suppressor operate and how one can interfere or boost their actions respectively to treat prostate cancer. ..
- Tibor T Glant; Fiscal Year: 2016....
- Carole R Mendelson; Fiscal Year: 2016....
- FASEB SRC on Lysophospholipd Mediators in Health and DiseaseJulie D Saba; Fiscal Year: 2011....
- Bandana Chatterjee; Fiscal Year: 2016..Information gleaned from our research may open up new strategies for prevention and clinical management of prostate cancer. ..
- Gamma-Synuclein-Mediated Regulation of Norepinephrine TransporterAnita Sidhu; Fiscal Year: 2010..This grant is also relevant for the ARRA in that it will immediately create 3 new professional jobs. ..
- Neil W Kowall; Fiscal Year: 2014..The urgent need for such studies is highlighted by the prospect that hundreds of thousands of future veterans may be at increased risk for this devastating disease. ..
- Randal J Kaufman; Fiscal Year: 2014..The proposed studies on protein synthesis will provide vital information that should encourage the development of novel therapeutics to treat diabetes. ..
- The role of Fli1 in T cell function and the pathogenesis of lupusTamara K Nowling; Fiscal Year: 2011..Additionally, insight will be gained into the regulation of T cell function in both health and disease with relevance to an array of immune and neoplastic diseases. ..
- Lung Lysyl Oxidase Regulation by Metal Ion HomeostasisWande Li; Fiscal Year: 2013..The outcomes of the proposed research are expected to enhance our understanding of mechanisms of LO gene silence by Cd providing the basis for developing prophylaxis and treatment strategies for Cd-related lung diseases. ..
- Bayar Thimmapaya; Fiscal Year: 2016....
- Targeted siRNA nanotechnology for intravesical treatment of urologicaldiseasesRobert M Weiss; Fiscal Year: 2010..Our first test of these nanoparticles will use a mouse model of bladder cancer. Thus, we can determine the therapeutic potential of siRNA for treatment of urologic diseases. ..
- Mitchell Kronenberg; Fiscal Year: 2014..This proposal will study the mechanisms by which the immune responses are properly controlled. Such knowledge will eventually facilitate the design of novel therapeutic approaches for immunological diseases. ..
- Targeting Inflammation for the Amelioration of Cisplatin-Hearing LossVickram Ramkumar; Fiscal Year: 2011..We believe the information gained from this study will lead to potentially new treatments for treating hearing loss. ..
- Role of IKK in NSCLC: Modulation of SMRT and NF-kappaBMarty W Mayo; Fiscal Year: 2012..The overall goal of this project is use these newly identified gene products as novel therapeutic targets for detection and treatment of NSCLC. ..
- Skeletal Muscle. Ca Release Control Inside the Sarcoplasmic Reticulum.Eduardo Rios; Fiscal Year: 2013..As a result there will be multiple repercussions to their defects or failures. It can be anticipated, therefore, that our research will have consequences outside its field of muscle and exercise. ..
- Robert T Means; Fiscal Year: 2014..The proposed studies can potentially lead to an enhanced understanding of the mechanisms of ACD, and therefore to more effective therapy. ..
- Vitamin D and Estrogen Action in Bone: Concerted Role for hnRNPs in the C FamilyJohn S Adams; Fiscal Year: 2013....
- DNA methylation of extracellular superoxide dismutase in pulmonary hypertensionEVA NOZIK GRAYCK; Fiscal Year: 2012..abstract_text> ..
- Rajvir Dahiya; Fiscal Year: 2015..Since the goal of this proposal is to investigate the dietary mediated inhibition of RCC through activation of tumor suppressor miRNAs, we believe that the work proposed is highly relevant to Veterans health and the VA mission. ..
- BIOSYNTHESIS OF TRACHEAL MUCOUS GLYCOPROTEINSPi Wan Cheng; Fiscal Year: 2010..Current studies could facilitate the development of therapy for mucus hypersecretory diseases through identification of small carbohydrate inhibitors and mucus cell-specific promoter. ..
- Maria Diakonova; Fiscal Year: 2014..Understanding how these proteins work together will help to design new therapeutic approaches and possibly drugs for treatment of different human diseases and breast cancer. ..
- Hydrodynamic forces modulate renal tubular functionRajeev Rohatgi; Fiscal Year: 2012....
- Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated DementiaXavier Grana; Fiscal Year: 2010....
- INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEMJERROLD MICHAEL OLEFSKY; Fiscal Year: 2013..These studies should lead to an improved understanding of the basic causes of Type 2 diabetes mellitus and hold the potential for new therapeutic modalities. ..
- DHAN V KALVAKOLANU; Fiscal Year: 2014..Studies proposed in this application will investigate the regulation of an anti-metastatic gene, DAPK1, which is critical for tumor suppression and autophagic responses. ..
- TLR4 Inhibition to Reduce Cerebral Ischemia Reperfusion InjuryLORI ANN HOLLE; Fiscal Year: 2011....
- Mitzi Nagarkatti; Fiscal Year: 2015..abstract_text> ..
- Xianglin Shi; Fiscal Year: 2015..Present study attempts to identify cyanidin-3-glucoside, a plant-derived compound, as a mechanism-based preventive agent against UV-induced skin cancers. ..
- Balakuntalam S Kasinath; Fiscal Year: 2016..Upstream regulators and downstream effectors of GSK 3beta in transcription and translation pathways involved in matrix protein synthesis will be explored in renal tissues as stated in Aim 1. ..
- MATTHEW PETER COGGINS; Fiscal Year: 2014..abstract_text> ..
- ICSBP Function During Myeloid DifferentiationELIZABETH ANN EKLUND; Fiscal Year: 2011..Functional characterization of such a pathway has implications for identifying early markers of disease progression in human myeloid malignancy and rational targets for molecular therapeutic approaches to diseases such as CML and MDS. ..
- Fatty acid related regulation of enteric infectious diseaseFREDRICK JON KULL; Fiscal Year: 2012....
- John S Davis; Fiscal Year: 2014..Considering the importance sex steroids in health and disease, we must have a better understanding of the mechanisms controlling the synthesis of steroid hormones. ..
- Laura L Dugan; Fiscal Year: 2014..abstract_text> ..
- Steroid Responsive Mechanisms in the EarDENNIS ROYAL TRUNE; Fiscal Year: 2012..Of particular interest are immune suppression of inflammatory cytokines and related transcription factors compared to the regulation of ion transport pathways that control fluid homeostasis. ..
- UTPAL BHAGIRATH PAJVANI; Fiscal Year: 2015..Pajvani will need in order to become an independent translational medical researcher and a productive member of the academic medical community. ..
- Mahin D Maines; Fiscal Year: 2015..In addition, the enzyme activity is necessary for protection against the fatal "green jaundice". Our work has revealed a novel approach for development of therapeutic interventions in a range of human diseases. ..
- Sirtuin/FOXO Signaling in the Regulation of Bone MassStavroula Kousteni; Fiscal Year: 2012..An interaction between this pathway and 2-catenin may enhance FOXO1-mediated transcription and regulate the anti-osteoclastogenic properties of 2-catenin. ..
- John Y L Chiang; Fiscal Year: 2016..The long-term objectives of this research are to elucidate the molecular mechanism of regulation of CYP7A1 and bile acid metabolism, and pathogenesis and treatment of metabolic diseases such as fatty liver disease, diabetes and obesity. ..
- Analysis of gene regulation of Vibrio cholerae during infectionJun Zhu; Fiscal Year: 2013..cholerae in vivo survival strategies and shed new light on the host-pathogen interactions that underpin infections by related enteric bacterial pathogens. ..
- Interdisciplinary Research Training in Reproduction for Indian FellowsJohn C Herr; Fiscal Year: 2010..abstract_text> ..
- Yaya Wang; Fiscal Year: 2014..In this grant I wil study the function of a genetic variant associated with multiple autoimmune diseases, the PTPN22 1858T variant, to examine its role in immune responses and disease pathogenesis. ..
- FOXP3-microRNA146-NFkB Axis in Tumor SuppressionLizhong Wang; Fiscal Year: 2013..abstract_text> ..
- A quantitative proteomics approach to understand viral immune evasion strategiesMichele E Hardy; Fiscal Year: 2010..Understanding these pathways and the mechanisms by which viruses evade the innate immune response may lead new approaches to attenuated vaccines or antiviral drug targets specifically designed to bypass viral evasion strategies. ..
- Mechanisms of Endothelin 1-Induced Sickle Cell PathologyAlicia Rivera; Fiscal Year: 2011..We plan to characterize mechanisms of ET-1-stimulated sickle red cell dehydration as a means to develop ET-1 receptor antagonists as a novel therapy in the treatment of sickle cell disease. ..
- Christie P Thomas; Fiscal Year: 2014....
- Regulation of the Vibrio cholerae intestinal exit planANISIA J SILVA BENITEZ; Fiscal Year: 2010..cholerae detachment and the role of protease production and motility in this process. These studies could open new avenues to treat cholera and shed light on the epidemic potential of this pathogen. ..
- ER stress: role in myocyte apoptosis and myocardial remodelingKrishna Singh; Fiscal Year: 2013..The proposed studies investigating the role of ER stress in cardiac myocyte apoptosis and myocardial remodeling may uncover novel therapeutic strategies for the treatment of heart failure. ..
- Donald B Jump; Fiscal Year: 2015..Defining the mechanistic linkage between PUFA synthesis, TAG hydrolysis, FoxO1, GNG &stress pathways will identify novel methods to manage diabetic complications, like hyperglycemia &fatty liver. ..
- Role of Mitochondria in the Regulation of Iron metabolism by AlcoholDUYGU DEE DEE HARRISON-FINDIK; Fiscal Year: 2012..The knowledge obtained from these studies, characterizing the pivotal role of mitochondria, will enable us to determine the mechanisms of liver injury caused by iron and alcohol in patients with ALD. ..
- Present Homologous and Heterologous Antigen with Hepatitis E VirusR Holland Cheng; Fiscal Year: 2012....
- Human Beta-Defensin-1 in HSV-1 Innate ImmunityLISA KATHLEEN RYAN; Fiscal Year: 2010..The long-range goal of our research is to understand the role of -defensins in the innate immune defense against viruses so that novel therapies can be developed from our findings. ..
- Cell signaling as a leukemia biomarkerJAMES WILLIAM JACOBBERGER; Fiscal Year: 2013....
- Alvaro Puga; Fiscal Year: 2015....
- An Aldosterone-Endothelin Feedback Mechanism on Sodium HomeostasisCharles S Wingo; Fiscal Year: 2012..Importantly, these studies will lend understanding into a novel signaling pathway that may explain the role of aldosterone in the progression of cardiovascular and renal disease. ..
- ELIZABETH ANN EKLUND; Fiscal Year: 2016..Targeting these mechanisms may lead to cure in CML by abolishing the CSC/LSC, and suggest therapeutic approaches to other forms of cancer with dysregulation of Fas and bcatenin. ..
- Howard B Lieberman; Fiscal Year: 2016....
- Integrated signaling of eicosanoids in HSC formation and regenerationTrista E North; Fiscal Year: 2013..These results are expected to reveal deeper insight into interactive roles of inflammatory mediators in marrow regeneration and have relevance for combinatorial targeting to direct clinical outcome in transfusion biology. ..
- Vickram Ramkumar; Fiscal Year: 2016..Overall, we believe that this study will provide the basis for the use of transplatin to alleviate cisplatin toxicities in cancer patients. ..
- Protection of Brain Injury from Cyanide Poisoning by Carnosic AcidStuart A Lipton; Fiscal Year: 2013..To investigate neuroprotective effects of CA in an in vitro model of cyanide poisoning. Specific Aim 2. To examine neuroprotective effects of CA in an in vivo mouse model mimicking the effects of cyanide ingestion. ..
- RSK-2 regulates integrin-mediated adhesion and migrationJOE WILLIAM RAMOS; Fiscal Year: 2013..This will determine if these proteins are suitable targets for the development of new adhesion specific disease therapies. In particular we will test if RSK2 can serve as a potential new therapeutic target in glioma. ..
- Patrick Cahan; Fiscal Year: 2016..An extensive program of formal training, course-work, meetings with the advisory committee, and dedicated supervision and mentorship by Dr. Daley will ensure that these goals are achieved. ..
- ERIC KIRK LAU; Fiscal Year: 2014..abstract_text> ..
- Papasani V Subbaiah; Fiscal Year: 2016....
- Epigenetic downregulation of the antibody response and inhibition of autoimmunityPaolo Casali; Fiscal Year: 2013....
- Claire Larmonier; Fiscal Year: 2014..Those specific aims will help address the following hypothesis: PARP1 contributes to aggravated mucosal immune response via modulation of inflammatory signaling pathways within the cells of the innate immune system. ..
- Paul M Lieberman; Fiscal Year: 2016..More detailed understanding of EBNA1 is further justified by its potential value as a target for therapeutic intervention in diseases and cancers associated with EBV latent infection. ..
- ANASTACIA GRIEGO; Fiscal Year: 2016..Additionally, we will have learned critical aspects of the interplay between host and virus that may underlie progression to cancer and/or prognosis of HPV[+] lesions. ..
- Michael J Brenner; Fiscal Year: 2016..The long-term goal of this research is to develop safe and effective strategies to prevent hearing loss related to aminoglycoside antibiotic therapy. ..
- Kip E Guja; Fiscal Year: 2014..The goal of this proposal is to provide a more complete understanding of how TFB proteins influence disease pathogenesis by elucidating the roles that they play in mitochondrial gene expression. ..
- High-affinity RNA targets of Survival Motor Neuron ProteinRavindra N Singh; Fiscal Year: 2013..Our proposal has potential to identify novel SMN functions with significance to a better understanding of molecular mechanism of SMA pathogenesis. ) ..
- Paul Sumby; Fiscal Year: 2014..Public health may be enhanced through the long-term goal of translating knowledge of FASX regulatory pathways into new treatment and/or preventative regimes based upon the inhibition of these pathways by novel antimicrobial agents. ..
- Mitzi Nagarkatti; Fiscal Year: 2015..These studies should provide novel insights into the basic mechanisms through which plant indoles exhibit anti- inflammatory properties so that they can be used against a wide range of autoimmune and inflammatory diseases. ..
- Subbiah Pugazhenthi; Fiscal Year: 2016..Our lab has 15 years of experience and the expertise to examine CREB function in the context of parallel activation of competing transcription factors during inflammation and oxidative stress. ..
- Prasanna Krishnamurthy; Fiscal Year: 2016....
- REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORIYoshio Yamaoka; Fiscal Year: 2013..This project will be able to identify novel therapeutic targets for the treatment of Helicobacter pylori infections and prevention of Helicobacter pylori-related diseases. ..
- Maha Abdellatif; Fiscal Year: 2016..2) Determine the role of TFIIB in gene transcription and the development of cardiac hypertrophy. 3) Determine the role of Cdk9 in gene transcription and the development of cardiac hypertrophy. ..
- Devendra K Agrawal; Fiscal Year: 2016..The proposed studies will provide conceptual support of our hypothesis and position us to translate our investigation into a clinical study in obese patients with coronary artery disease. ..
- Robert Paine; Fiscal Year: 2016..Thus, they have the potential to provide new therapeutic approaches to restore alveolar epithelial integrity while limiting unintended adverse effects. ..
- Laurie J Ozelius; Fiscal Year: 2016..Identification of a final common pathway in different forms of EOTD will aid in directing discovery of therapeutic targets for this currently incurable disorder. ..
- Li Wang; Fiscal Year: 2015..Fully defining the regulation of bile acid metabolism, including bile acid synthesis and catabolism, is essential for further advances in diagnosis, management, and prevention of cholestatic liver diseases. ..
- RNA polymerase II Elongation Complex: Structure and FunctionDaniel Reines; Fiscal Year: 2013..The parts of the transcription machinery studied here are involved in neurological, visual, and immunological diseases. ..
- John R Hoidal; Fiscal Year: 2016..It will impact our ability to prevent or reduce the enormous medical burden caused by cigarette smoking. Nowhere is the need for new approaches with clinical application more important in pulmonary diseases than in COPD. ..
- ANDREW GEORGE MUNTEAN; Fiscal Year: 2014..These studies focus on the MLL-PAFc interaction and ubiquitination of MLL which are directly relevant to MLL and HOX dependent leukemias and may prove as effective therapeutic targets. ..
- Transcriptional Control by the Global Regulator SpxPETER A ZUBER; Fiscal Year: 2013..The regulatory protein Spx controls important components of the bacterial response to oxidative attack, and the study of its mechanism of action will uncover targets for neutralizing infectious microorganisms. ..
- Gerald Shadel; Fiscal Year: 2016..Knowledge gained from these studies holds therapeutic promise for mitochondrial disease and age-related pathology based on augmenting mitochondrial gene expression and directly addresses the human disorders obesity and Leigh Syndrome. ..
- Functional Studies of Variants of the Bipolar Risk Gene CACNA1C in Human NeuronsJEN PAN; Fiscal Year: 2013....
- Danny J Schust; Fiscal Year: 2016..We will test this hypothesis in vitro using iPSCs derived from the umbilical cords of babies born to mothers with severe preeclampsia and gestational age-matched control iPSCs. ..
- Regulation of ENaC TranscriptionBruce C Kone; Fiscal Year: 2013..This proposal examines a novel network of interacting proteins in the cell nucleus that regulate transcription, the initial molecular step in generating this protein. ..
- Navdeep S Chandel; Fiscal Year: 2015....
- Geoffrey I Shapiro; Fiscal Year: 2014..abstract_text> ..
- Dan Littman; Fiscal Year: 2016..Together, these studies will provide a better understanding of the mechanism of action of RORyt and will facilitate new strategies for therapy in autoimmune diseases. ..