genetic epistasis

Summary

Summary: A gene interaction whereby the expression of one gene interfers with or masks the expression of a different gene or genes. Genes whose expression interfers with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is effected (blocked or masked) are hypostatic to the interfering genes.

Top Publications

  1. ncbi Epistasis and the release of genetic variation during long-term selection
    Orjan Carlborg
    Linnaeus Centre for Bioinformatics, Uppsala University, Box 598, SE 75124 Uppsala, Sweden
    Nat Genet 38:418-20. 2006
  2. pmc Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems
    Patrick C Phillips
    Center for Ecology and Evolution, University of Oregon, Eugene, Oregon 97403 USA
    Nat Rev Genet 9:855-67. 2008
  3. ncbi Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions
    Lance W Hahn
    Program in Human Genetics and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Bioinformatics 19:376-82. 2003
  4. ncbi Epistasis: too often neglected in complex trait studies?
    Orjan Carlborg
    Linnaeus Centre for Bioinformatics, Uppsala University, BMC, Box 598, SE 751 24 Uppsala, Sweden
    Nat Rev Genet 5:618-25. 2004
  5. ncbi A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility
    Jason H Moore
    Computational Genetics Laboratory, Department of Genetics, Dartmouth Hitchcock Medical Center, One Medical Center Dr, 706 Rubin Bldg, HB7937, Lebanon, NH 03756, USA
    J Theor Biol 241:252-61. 2006
  6. ncbi Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans
    Heather J Cordell
    University of Cambridge, Department of Medical Genetics, JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    Hum Mol Genet 11:2463-8. 2002
  7. ncbi Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map
    Sean R Collins
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA
    Nature 446:806-10. 2007
  8. ncbi Perspective: Evolution and detection of genetic robustness
    J Arjan G M de Visser
    Department of Genetics, Wageningen University, Arboretumlaan 4, 6703 BD Wageningen, The Netherlands
    Evolution 57:1959-72. 2003
  9. pmc Epistasis for fitness-related quantitative traits in Arabidopsis thaliana grown in the field and in the greenhouse
    Russell L Malmberg
    Department of Plant Biology, 2502 Plant Sciences Building, University of Georgia, Athens, GA 30602, USA
    Genetics 171:2013-27. 2005
  10. ncbi Epistasis between deleterious mutations and the evolution of recombination
    Roger D Kouyos
    Institute of Integrative Biology, ETH Zürich Universitätsstrasse 16, 8092, Zurich, Switzerland
    Trends Ecol Evol 22:308-15. 2007

Detail Information

Publications250 found, 100 shown here

  1. ncbi Epistasis and the release of genetic variation during long-term selection
    Orjan Carlborg
    Linnaeus Centre for Bioinformatics, Uppsala University, Box 598, SE 75124 Uppsala, Sweden
    Nat Genet 38:418-20. 2006
    ..The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model...
  2. pmc Epistasis--the essential role of gene interactions in the structure and evolution of genetic systems
    Patrick C Phillips
    Center for Ecology and Evolution, University of Oregon, Eugene, Oregon 97403 USA
    Nat Rev Genet 9:855-67. 2008
    ....
  3. ncbi Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions
    Lance W Hahn
    Program in Human Genetics and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Bioinformatics 19:376-82. 2003
    ..In this paper, we describe the MDR approach and an MDR software package...
  4. ncbi Epistasis: too often neglected in complex trait studies?
    Orjan Carlborg
    Linnaeus Centre for Bioinformatics, Uppsala University, BMC, Box 598, SE 751 24 Uppsala, Sweden
    Nat Rev Genet 5:618-25. 2004
  5. ncbi A flexible computational framework for detecting, characterizing, and interpreting statistical patterns of epistasis in genetic studies of human disease susceptibility
    Jason H Moore
    Computational Genetics Laboratory, Department of Genetics, Dartmouth Hitchcock Medical Center, One Medical Center Dr, 706 Rubin Bldg, HB7937, Lebanon, NH 03756, USA
    J Theor Biol 241:252-61. 2006
    ..We then apply this strategy to detecting, characterizing, and interpreting epistatic models in a genetic study (n = 500) of atrial fibrillation and show that both classification and model interpretation are significantly improved...
  6. ncbi Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans
    Heather J Cordell
    University of Cambridge, Department of Medical Genetics, JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    Hum Mol Genet 11:2463-8. 2002
    ..A brief survey of some methods for detecting epistasis in humans is given. We note that the degree to which statistical tests of epistasis can elucidate underlying biological interactions may be more limited than previously assumed...
  7. ncbi Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map
    Sean R Collins
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA
    Nature 446:806-10. 2007
    ..This modification, in turn, enables a ubiquitin ligase complex containing the cullin Rtt101 to ensure genomic integrity during DNA replication...
  8. ncbi Perspective: Evolution and detection of genetic robustness
    J Arjan G M de Visser
    Department of Genetics, Wageningen University, Arboretumlaan 4, 6703 BD Wageningen, The Netherlands
    Evolution 57:1959-72. 2003
    ....
  9. pmc Epistasis for fitness-related quantitative traits in Arabidopsis thaliana grown in the field and in the greenhouse
    Russell L Malmberg
    Department of Plant Biology, 2502 Plant Sciences Building, University of Georgia, Athens, GA 30602, USA
    Genetics 171:2013-27. 2005
    ..Our results support the idea that epistatic interactions are an important part of natural genetic variation and reinforce the need for caution in comparing results from greenhouse-grown and field-grown plants...
  10. ncbi Epistasis between deleterious mutations and the evolution of recombination
    Roger D Kouyos
    Institute of Integrative Biology, ETH Zürich Universitätsstrasse 16, 8092, Zurich, Switzerland
    Trends Ecol Evol 22:308-15. 2007
    ..Here, we assess these criticisms and discuss to what extent they invalidate the MDH as an explanation for the evolution of recombination...
  11. ncbi Genetic association studies
    Heather J Cordell
    University of Cambridge, Department of Medical Genetics, Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Addenbrookes Hospital, UK
    Lancet 366:1121-31. 2005
    ..As with other types of genetic epidemiological study, issues of design, statistical analysis, and interpretation are very important...
  12. pmc Multiple interval mapping for quantitative trait loci
    C H Kao
    Institute of Statistical Science, Academia Sinica, Taipei 11529, Taiwan, Republic of China
    Genetics 152:1203-16. 1999
    ..The MIM FORTRAN program is available on the worldwide web (http://www.stat.sinica.edu.tw/chkao/)...
  13. ncbi SNPHarvester: a filtering-based approach for detecting epistatic interactions in genome-wide association studies
    Can Yang
    Laboratory for Bioinformatics and Computational Biology, Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Bioinformatics 25:504-11. 2009
    ..Hence, it is desirable to develop an effective method to search epistatic interactions in genome-wide scale...
  14. ncbi Perspective: Sign epistasis and genetic constraint on evolutionary trajectories
    Daniel M Weinreich
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Evolution 59:1165-74. 2005
    ..These theoretical and empirical considerations imply that strong genetic constraint on the selective accessibility of trajectories to high fitness genotypes may exist and suggest specific areas of investigation for future research...
  15. ncbi The biochemical architecture of an ancient adaptive landscape
    Mark Lunzer
    Biotechnology Institute, Evolution and Behavior, University of Minnesota, St Paul, MN 55108, USA
    Science 310:499-501. 2005
    ..The genotype-phenotype-fitness map shows that NAD use is a global optimum...
  16. ncbi Computational analysis of gene-gene interactions using multifactor dimensionality reduction
    Jason H Moore
    Dartmouth Medical School, Computational Genetics Laboratory, 706 Rubin Building, HB7937, One Medical Center Drive, Lebanon, NH 03756, USA
    Expert Rev Mol Diagn 4:795-803. 2004
    ..Several case studies that demonstrate the detection of gene-gene interactions in common diseases such as atrial fibrillation, Type II diabetes and essential hypertension are also discussed...
  17. ncbi Distributions of epistasis in microbes fit predictions from a fitness landscape model
    Guillaume Martin
    Centre d écologie fonctionnelle et évolutive Centre National de la Recherche Scientifique UMR 5175, 1919 Route de Mende, 34293 Montpellier, France
    Nat Genet 39:555-60. 2007
    ..This model may offer a simple and widely applicable alternative to complex metabolic network models, in particular for making evolutionary predictions...
  18. pmc A unified model for functional and statistical epistasis and its application in quantitative trait Loci analysis
    José M Alvarez-Castro
    Linnaeus Centre for Bioinformatics, Uppsala University, SE 75124 Uppsala, Sweden
    Genetics 176:1151-67. 2007
    ..Furthermore, we use our theoretical foundations to conceptually clarify functional and statistical epistasis, discuss the advantages of NOIA over previous theory, and stress the importance of linking functional and statistical models...
  19. ncbi The ubiquitous nature of epistasis in determining susceptibility to common human diseases
    Jason H Moore
    Program in Human Genetics, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Hum Hered 56:73-82. 2003
    ..If this working hypothesis is true, it suggests that we need a research strategy for identifying common disease susceptibility genes that embraces, rather than ignores, the complexity of the genotype to phenotype relationship...
  20. pmc Multidimensional epistasis and the disadvantage of sex
    F A Kondrashov
    National Center for Biotechnology Information, National Institutes of Health, Building 38A, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:12089-92. 2001
    ..Thus, either sex exists in spite of its impact on the rate of adaptive allele replacements, or natural fitness surfaces have rather specific properties, at least at the scale of intrapopulation genetic variability...
  21. pmc Multifactor dimensionality reduction for graphics processing units enables genome-wide testing of epistasis in sporadic ALS
    Casey S Greene
    Department of Genetics, Dartmouth Medical School, Lebanon, NH 03756, USA
    Bioinformatics 26:694-5. 2010
    ..Graphics processing units (GPUs), the hardware responsible for rendering computer games, are powerful parallel processors. Using GPUs to run MDR on a genome-wide dataset allows for statistically rigorous testing of epistasis...
  22. ncbi Darwinian evolution can follow only very few mutational paths to fitter proteins
    Daniel M Weinreich
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 312:111-4. 2006
    ..This implies that the protein tape of life may be largely reproducible and even predictable...
  23. ncbi Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex
    Michael Christopher Keogh
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 123:593-605. 2005
    ..This pathway apparently acts to negatively regulate transcription because deleting the genes for Set2 or Rpd3C(S) bypasses the requirement for the positive elongation factor Bur1/Bur2...
  24. ncbi Exploring genetic interactions and networks with yeast
    Charles Boone
    Banting and Best Department of Medical Research and Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto M5S 3E1, Canada
    Nat Rev Genet 8:437-49. 2007
    ..A comparative understanding of genetic-interaction networks promises insights into some long-standing genetic problems, such as the nature of quantitative traits and the basis of complex inherited disease...
  25. ncbi A support vector machine approach for detecting gene-gene interaction
    Shyh Huei Chen
    Department of Industrial Management, National Yunlin University of Science and Technology, Yunlin, Taiwan
    Genet Epidemiol 32:152-67. 2008
    ..We would like to make the support vector machine and combinatorial optimization techniques more accessible to genetic epidemiologists, and to promote the use and extension of these powerful approaches...
  26. ncbi Genome-wide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice
    K Shimomura
    Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois 60208 3520, USA
    Genome Res 11:959-80. 2001
    ....
  27. pmc The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene
    L Rong
    Department of Biochemistry, New York University Medical Center, New York 10016
    Genetics 127:75-85. 1991
    ..We propose that the HPR5 gene functions in the RAD6 repair pathway...
  28. ncbi Mesodermal cell fate decisions in Drosophila are under the control of the lineage genes numb, Notch, and sanpodo
    M Park
    Department of Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Mech Dev 75:117-26. 1998
    ....
  29. pmc Multiple pathways for homologous recombination in Saccharomyces cerevisiae
    A J Rattray
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032
    Genetics 139:45-56. 1995
    ..Furthermore, there is still considerably more recombination in rad1 rad51 mutants than in rad52 mutants, indicating the presence of another, as yet unidentified, recombination pathway...
  30. ncbi Pervasive joint influence of epistasis and plasticity on mutational effects in Escherichia coli
    Susanna K Remold
    Center for Microbial Ecology, Michigan State University, East Lansing, 48824, USA
    Nat Genet 36:423-6. 2004
    ..mutations on phenotype and fitness may depend on the environment (phenotypic plasticity), other mutations (genetic epistasis) or both. Here we examine the fitness effects of 18 random insertion mutations in E...
  31. ncbi Effects of genetic drift on variance components under a general model of epistasis
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, EH9 3JT, United Kingdom
    Evolution 58:2111-32. 2004
    ..Although our analyses clarify the conditions under which drift is expected to increase V(A), we question the evolutionary importance of such increases...
  32. ncbi SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase
    Boris Pfander
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nature 436:428-33. 2005
    ..Our finding suggests a model in which SUMO-modified PCNA recruits Srs2 in S phase in order to prevent unwanted recombination events of replicating chromosomes...
  33. ncbi Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
    Maureen P Martin
    Basic Research Program, SAIC Frederick, Frederick, Maryland 21702 1201, USA
    Nat Genet 31:429-34. 2002
    ..The strongest synergistic effect of these loci was on progression to depletion of CD4(+) T cells, which suggests that a protective response of NK cells involving KIR3DS1 and its HLA class I ligands begins soon after HIV-1 infection...
  34. ncbi Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS
    J B Skeath
    Department of Cell and Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana, Illinois 61801, USA
    Development 125:1857-65. 1998
    ..Taken together, these results show that interactions between sanpodo, the Notch signaling pathway and numb enable CNS sibling neurons to acquire different fates...
  35. ncbi Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity
    Marylyn D Ritchie
    Program in Human Genetics and Department of Molecular Physiology and Biophysics, Vanderbilt University Medical School, Nashville, TN 37232 0700, USA
    Genet Epidemiol 24:150-7. 2003
    ..Extending MDR to address genetic heterogeneity should be a priority for the continued methodological development of this new approach...
  36. ncbi Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections
    Servane Tauszig-Delamasure
    UPR9022 du Centre National de la Recherche Scientifique, Institut de Biologie Moleculaire et Cellulaire, 15, rue René Descartes, 67000 Strasbourg, France
    Nat Immunol 3:91-7. 2002
    ..Phenotypic comparison of DmMyD88-mutant flies and MyD88-deficient mice showed essential differences in the control of Gram-negative infection in insects and mammals...
  37. pmc Drug interactions modulate the potential for evolution of resistance
    Jean Baptiste Michel
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:14918-23. 2008
    ..This framework reveals the central role of drug epistasis in the evolution of resistance and points to new strategies for combating the emergence of drug-resistant bacteria...
  38. ncbi UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiae
    J Brusky
    Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Canada
    Curr Genet 37:168-74. 2000
    ..The involvement of UBC13 in cellular tolerance to DNA-damage is further implicated by our finding that the UBC13 transcript level is increased up to 6-fold in response to DNA-damage...
  39. ncbi Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile
    Maya Schuldiner
    Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, California 94143, USA
    Cell 123:507-19. 2005
    ..Extension of this strategy to other logically connected gene subsets in yeast and higher eukaryotes should provide critical insights into the functional/organizational principles of biological systems...
  40. pmc A strategy for extracting and analyzing large-scale quantitative epistatic interaction data
    Sean R Collins
    Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California San Francisco and California Institute for Quantitative Biomedical Research, San Francisco, California 94143, USA
    Genome Biol 7:R63. 2006
    ....
  41. pmc Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast
    Denise Hanway
    Department of Chemistry and Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 99:10605-10. 2002
    ..Epistatsis analysis of four of the genes was performed to determine the DNA damage repair pathways in which the protein products function...
  42. ncbi Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila
    Daven C Presgraves
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Nature 423:715-9. 2003
    ..These results show that a lethal hybrid incompatibility has evolved as a by-product of adaptive protein evolution...
  43. pmc Single QTL effects, epistasis, and pleiotropy account for two-thirds of the phenotypic F(2) variance of growth and obesity in DU6i x DBA/2 mice
    G A Brockmann
    Research Institute for the Biology of Farm Animals, 18196 Dummerstorf, Germany
    Genome Res 10:1941-57. 2000
    ..The quantitative trait loci described in this paper have been submitted to the Mouse Genome Database.]..
  44. ncbi Predictive rule inference for epistatic interaction detection in genome-wide association studies
    Xiang Wan
    Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong, China
    Bioinformatics 26:30-7. 2010
    ..In this work, we propose a novel learning approach (SNPRuler) based on the predictive rule inference to find disease-associated epistatic interactions...
  45. pmc Genomewide analysis of epistatic effects for quantitative traits in barley
    Shizhong Xu
    Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    Genetics 175:1955-63. 2007
    ..This invalidates the common practice of epistatic analysis in which epistatic effects are estimated only for pairs of loci of which both have main effects...
  46. ncbi Interactions between HERC2, OCA2 and MC1R may influence human pigmentation phenotype
    Wojciech Branicki
    Institute of Forensic Research, Section of Forensic Genetics, Westerplatte 9, Krakow, Poland
    Ann Hum Genet 73:160-70. 2009
    ..Finally, using various approaches we were able to show that there is an interaction between MC1R and HERC2 in determination of skin and hair colour in the studied population sample...
  47. ncbi Why sex and recombination?
    N H Barton
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Science 281:1986-90. 1998
    ..Various processes that can cause such an effect have been studied theoretically. It has, however, so far proved hard to discriminate among them empirically...
  48. pmc Analysis of epistatic interactions and fitness landscapes using a new geometric approach
    Niko Beerenwinkel
    Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA
    BMC Evol Biol 7:60. 2007
    ..In this paper, we propose and employ a new mathematical approach that allows a more complete description of multi-way interactions and provides new insights into the structure of fitness landscapes...
  49. ncbi Foxi3 transcription factors and Notch signaling control the formation of skin ionocytes from epidermal precursors of the zebrafish embryo
    Martina Janicke
    Max Planck Institute of Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Dev Biol 307:258-71. 2007
    ..A model for ionocyte versus keratinocyte development will be presented, postulating additional thus far unidentified pro-ionocyte factors...
  50. ncbi Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice
    Michael G Anderson
    The Howard Hughes Medical Institute, Bar Harbor, Maine 04609, USA
    Nat Genet 30:81-5. 2002
    ..The fact that hypopigmentation profoundly alleviates the D2 disease indicates that therapeutic strategies designed to decrease pigment production may be beneficial in human pigmentary glaucoma...
  51. pmc The genetic architecture of response to long-term artificial selection for oil concentration in the maize kernel
    Cathy C Laurie
    Monsanto Company, St Louis, Missouri 63167, USA
    Genetics 168:2141-55. 2004
    ..The large number of QTL detected accounts for the smooth and sustained response to selection throughout the twentieth century...
  52. ncbi Factors affecting the genetic load in Drosophila: synergistic epistasis and correlations among fitness components
    M C Whitlock
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Evolution 54:1654-60. 2000
    ....
  53. ncbi Genetic analysis identifies quantitative trait loci controlling rosette mineral concentrations in Arabidopsis thaliana under drought
    Artak Ghandilyan
    Laboratory of Genetics, Wageningen University, NL 6703 BD Wageningen, The Netherlands
    New Phytol 184:180-92. 2009
    ..The low number of common mineral concentration QTLs, shared among different RIL populations, tissues and conditions in Arabidopsis, suggests that breeding for robust, mineral biofortified crops will be complex...
  54. pmc Modeling synthetic lethality
    Nolwenn Le Meur
    Division of Public Health Sciences, Fred Hutchinson Cancer Center Research, Program in Computational Biology, Seattle, WA 98109, USA
    Genome Biol 9:R135. 2008
    ..We propose statistical and computational tools that can be used to find relationships between synthetic lethality and cellular organizational units...
  55. pmc Modeling epistasis of quantitative trait loci using Cockerham's model
    Chen Hung Kao
    Institute of Statistical Science, Academia Sinica, Taipei 11529, Taiwan, Republic of China
    Genetics 160:1243-61. 2002
    ..Real and simulated examples are used to illustrate Cockerham's model, compare different models, and map for epistatic QTL. Finally, we extend Cockerham's model to multiple loci and discuss its applications to QTL mapping...
  56. ncbi Constitutive disease resistance requires EDS1 in the Arabidopsis mutants cpr1 and cpr6 and is partially EDS1-dependent in cpr5
    J D Clarke
    Developmental, Cell, and Molecular Biology Group, Department of Botany, Box 91000, Duke University, Durham, North Carolina 27708-1000, USA
    Plant J 26:409-20. 2001
    ..The data allow us to place EDS1 as a necessary downstream component of cpr1- and cpr6-mediated responses, but suggest a more complex relationship between EDS1 and cpr5 in plant defense...
  57. ncbi Epistasis between new mutations and genetic background and a test of genetic canalization
    S F Elena
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva and Departament de Genètica, Universitat de Valencia, Spain
    Evolution 55:1746-52. 2001
    ..Thus, there is no evidence supporting the hypothesis that the derived bacteria had adapted, in part, by becoming buffered against the harmful effects of mutations...
  58. pmc A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence
    Xiang Yang Lou
    Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22911, USA
    Am J Hum Genet 80:1125-37. 2007
    ..In summary, GMDR serves the purpose of identifying contributors to population variation better than do the other existing methods...
  59. ncbi Bayesian inference of epistatic interactions in case-control studies
    Yu Zhang
    Department of Statistics, The Pennsylvania State University, Thomas Building 422A, University Park, Pennsylvania 16802, USA
    Nat Genet 39:1167-73. 2007
    ....
  60. ncbi Empirical fitness landscapes reveal accessible evolutionary paths
    Frank J Poelwijk
    FOM Institute AMOLF, Kruislaan 407, 1098 SJ, Amsterdam, The Netherlands
    Nature 445:383-6. 2007
    ..With this first view on empirical evolutionary landscapes, we can now finally start asking why particular evolutionary paths are taken...
  61. pmc Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum
    Martin C Jonikas
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Science 323:1693-7. 2009
    ..The use of a quantitative reporter in a comprehensive screen followed by systematic analysis of genetic dependencies should be broadly applicable to functional dissection of complex cellular processes from yeast to human...
  62. pmc A global search reveals epistatic interaction between QTL for early growth in the chicken
    Orjan Carlborg
    Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, S 751 24 Uppsala, Sweden
    Genome Res 13:413-21. 2003
    ..Several of the detected loci affected either early or late growth but not both. Very few loci affected the entire growth process, which points out that early and late growth, at least to some extent, have different genetic regulation...
  63. pmc Statistical modeling of interlocus interactions in a complex disease: rejection of the multiplicative model of epistasis in type 1 diabetes
    H J Cordell
    Department of Medical Genetics, University of Cambridge, Wellcome Trust Centre for Molecular Mechanisms in Disease, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2XY, United Kingdom
    Genetics 158:357-67. 2001
    ..The degree to which statistical analyses can elucidate underlying biologic mechanisms may be limited and may require prior knowledge of the underlying etiology...
  64. pmc Towards accurate imputation of quantitative genetic interactions
    Igor Ulitsky
    Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv 69978, Israel
    Genome Biol 10:R140. 2009
    ..Here we present a novel method, which combines genetic interaction data together with diverse genomic data, to quantitatively impute these missing interactions. We also present data on almost 190,000 novel interactions...
  65. pmc Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair
    Lorraine S Symington
    Department of Microbiology and Institute of Cancer Research, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Microbiol Mol Biol Rev 66:630-70, table of contents. 2002
    ..Herein, I provide an overview of recent biochemical and structural analyses of the Rad52 group proteins and discuss how this information can be incorporated into genetic studies of recombination...
  66. ncbi Multilocus selection in subdivided populations II. Maintenance of polymorphism under weak or strong migration
    Reinhard Burger
    Department of Mathematics, University of Vienna, Vienna, Austria
    J Math Biol 58:979-97. 2009
    ..Thus, several scenarios are identified under which multilocus polymorphism can be maintained by migration-selection balance when this is impossible in a panmictic population...
  67. pmc Gene regulatory networks generating the phenomena of additivity, dominance and epistasis
    S W Omholt
    Department of Animal Science, Agricultural University of Norway, Aas
    Genetics 155:969-80. 2000
    ..Furthermore, the results illuminate and reconcile the prevailing explanations of heterosis, and they support the old conjecture that the phenomenon of dominance may have an evolutionary explanation related to life history strategy...
  68. ncbi An entropy-based approach for testing genetic epistasis underlying complex diseases
    Guolian Kang
    Department of Statistics and Probability, East Lansing, Michigan State University, MI 48824, USA
    J Theor Biol 250:362-74. 2008
    ..In this article, we introduce a new approach for testing genetic epistasis in multiple loci using an entropy-based statistic for a case-only design...
  69. pmc The gene controlling the quantitative trait locus EPITHIOSPECIFIER MODIFIER1 alters glucosinolate hydrolysis and insect resistance in Arabidopsis
    Zhiyong Zhang
    Department of Plant Sciences, University of California, Davis, California 95616, USA
    Plant Cell 18:1524-36. 2006
    ..The glucosinolate hydrolysis profile change influenced by ESM1 is associated with the ability to deter herbivory by Trichoplusia ni. This gene could provide unique approaches toward improving human nutrition...
  70. pmc A complete classification of epistatic two-locus models
    Ingileif B Hallgrimsdóttir
    Department of Statistics, University of Oxford, 1 South Parks Road, OX1 3TG, UK
    BMC Genet 9:17. 2008
    ..However, they left open the problem of finding a classification of two-locus models with continuous penetrance values...
  71. ncbi Epistasis in sporadic Alzheimer's disease
    Onofre Combarros
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas, Marques de Valdecilla University Hospital, University of Cantabria, Santander, Spain
    Neurobiol Aging 30:1333-49. 2009
    ..We conclude that epistasis is a crucial feature of complex diseases, that its study is a promising approach to the genetics of AD and that larger and more rigorous studies are needed to establish interactions...
  72. pmc Quantitative trait locus (QTL) mapping using different testers and independent population samples in maize reveals low power of QTL detection and large bias in estimates of QTL effects
    A E Melchinger
    Institute of Plant Breeding, Seed Science and Population Genetics, University of Hohenheim, 70593 Stuttgart, Germany
    Genetics 149:383-403. 1998
    ..We conclude that, unless QTL effects are estimated from an independent sample, they can be inflated, resulting in an overly optimistic assessment of the efficiency of MAS...
  73. pmc Statistical epistasis is a generic feature of gene regulatory networks
    Arne B Gjuvsland
    Centre for Integrative Genetics and Department of Animal and Aquacultural Sciences, Norwegian University of Life Sciences, N 1432 Aas, Norway
    Genetics 175:411-20. 2007
    ..This article illustrates how statistical genetic methods can fruitfully be combined with nonlinear systems dynamics to elucidate biological issues beyond reach of each methodology in isolation...
  74. ncbi Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci
    Ioannis M Stylianou
    The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA
    Mamm Genome 17:22-36. 2006
    ..Haplotype patterns and a literature-driven approach were used to generate hypotheses regarding the identity of the genes and pathways underlying the QTL...
  75. pmc Failure to replicate a genetic association may provide important clues about genetic architecture
    Casey S Greene
    Department of Genetics, Dartmouth College, Lebanon, New Hampshire, United States of America
    PLoS ONE 4:e5639. 2009
    ..We recommend that polymorphisms that fail to replicate be checked for interactions with other polymorphisms, particularly when samples are collected from groups with distinct ethnic backgrounds or different geographic regions...
  76. pmc Quantitative trait loci for maternal performance for offspring survival in mice
    Andréa C Peripato
    Department of Biology Genetics, IB, Universidade de Sao Paulo, Brazil
    Genetics 162:1341-53. 2002
    ....
  77. pmc A random forest approach to the detection of epistatic interactions in case-control studies
    Rui Jiang
    MOE Key Laboratory of Bioinformatics and Bioinformatics Division, TNLIST Department of Automation, Tsinghua University, Beijing 100084, PR China
    BMC Bioinformatics 10:S65. 2009
    ..It is therefore indispensable to develop new methods that are able to reduce the search space for epistatic interactions from an astronomic number of all possible combinations of genetic variants to a manageable set of candidates...
  78. ncbi Evidence for positive epistasis in HIV-1
    Sebastian Bonhoeffer
    Ecology and Evolution, ETH Zurich, ETH Zentrum NW, CH 8092 Zurich, Switzerland
    Science 306:1547-50. 2004
    ..Using amino acid sequence data and fitness values from 9466 human immunodeficiency virus 1 (HIV-1) isolates, we find in contrast to these theories strong statistical evidence for a predominance of positive epistasis in HIV-1...
  79. pmc Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast
    Assen Roguev
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
    Science 322:405-10. 2008
    ..Hence, conservation occurs at the level of the functional module (protein complex), but the genetic cross talk between modules can differ substantially...
  80. pmc Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models
    Todd L Edwards
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tenn, USA
    Hum Hered 67:183-92. 2009
    ..Previously unknown aspects of MDR performance were the power to detect interactive effects given large numbers of non-model loci or varying degrees of heterogeneity among multiple epistatic disease models...
  81. pmc Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila
    Kristi L Montooth
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genetics 165:623-35. 2003
    ..This has important consequences for the evolution of performance traits that depend upon these metabolic networks...
  82. ncbi Mapping the genetic architecture of complex traits in experimental populations
    Jian Yang
    Institute of Bioinformatics, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, PR China
    Bioinformatics 23:1527-36. 2007
    ..Two real-world phenotypes (BXD mouse olfactory bulb weight data and rice yield data) are used as exemplars to demonstrate our methods. AVAILABILITY: A software package is freely available at http://ibi.zju.edu.cn/software/qtlnetwork..
  83. pmc Parallel and serial computing tools for testing single-locus and epistatic SNP effects of quantitative traits in genome-wide association studies
    Li Ma
    Department of Animal Science, University of Minnesota, USA
    BMC Bioinformatics 9:315. 2008
    ..Computational difficulty is the main bottleneck for epistasis testing in large scale GWAS...
  84. pmc Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 70:230-6. 2002
    ..0004). These data suggest that variations in IL4RA contribute to elevated total serum IgE levels, and interaction between IL4RA and IL13 markedly increases an individual's susceptibility to asthma...
  85. ncbi A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction
    Digna R Velez
    Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee
    Genet Epidemiol 31:306-15. 2007
    ..These results suggest that balanced accuracy should be used instead of accuracy for the MDR analysis of epistasis in imbalanced datasets...
  86. pmc Bayesian mapping of genomewide interacting quantitative trait loci for ordinal traits
    Nengjun Yi
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama, Birmingham, Alabama 35294 0022, USA
    Genetics 176:1855-64. 2007
    ....
  87. ncbi Genetics and the fitness of hybrids
    J M Burke
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Annu Rev Genet 35:31-52. 2001
    ..In contrast, increased hybrid fitness can be most readily explained through the segregation of additive genetic factors, with epistasis playing a more limited role...
  88. ncbi Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein
    Shimon Bershtein
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Nature 444:929-32. 2006
    ..Threshold robustness is inherently epistatic-once the stability threshold is exhausted, the deleterious effects of mutations become fully pronounced, thereby making proteins far less robust than generally assumed...
  89. ncbi The biological basis of epistasis between quantitative trait loci for flavone and 3-deoxyanthocyanin synthesis in maize (Zea mays L.)
    M D McMullen
    Plant Genetics Research Unit, US Department of Agriculture, Agricultural Research Service, Columbia, MO 65211, USA
    Genome 44:667-76. 2001
    ..0001). Our results demonstrate that altering the flux of biochemical intermediates between pathways may be the biological basis of major QTL effects and epistatic interactions...
  90. ncbi Detection of gene x gene interactions in genome-wide association studies of human population data
    Solomon K Musani
    Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Hered 63:67-84. 2007
    ..Instead, a combination of approaches with the aim of balancing their specific strengths may be the optimal approach to investigate gene x gene interactions in human data...
  91. pmc Two-stage two-locus models in genome-wide association
    David M Evans
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 2:e157. 2006
    ....
  92. ncbi Little evidence for synergism among deleterious mutations in a nonsegmented RNA virus
    S F Elena
    Institut Cavanilles de Biodiversitat i Biologia Evolutiva and Department de Genètica, Universitat de Valencia, Apartado 22085, 46071 Valencia, Spain
    J Mol Evol 49:703-7. 1999
    ..However, the statistical uncertainties associated with the data still give some room for the existence of very weak synergistic epistasis...
  93. ncbi Gene actions of QTLs affecting several agronomic traits resolved in a recombinant inbred rice population and two testcross populations
    H W Mei
    Shanghai Agro Biological Gene Center, 2901 Beidi Road, Shanghai 201106, P R China
    Theor Appl Genet 107:89-101. 2003
    ..The implications of these results to the development of inbred and hybrid cultivars were discussed...
  94. ncbi Gene interactions from maternal effects
    J B Wolf
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Evolution 54:1882-98. 2000
    ..Three scenarios are presented to illustrate systems in which maternal-offspring, genotype-by-genotype epistasis may occur. The implications of maternal-offspring epistasis for quantitative-trait-loci studies are also discussed...
  95. pmc Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage t7
    Lingchong You
    Department of Chemical Engineering, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 160:1273-81. 2002
    ..Our approach demonstrates how computer simulations of developmental processes can be used to quantitatively study genetic interactions at the population level...
  96. ncbi Multilocus selection in subdivided populations I. Convergence properties for weak or strong migration
    Reinhard Burger
    Department of Mathematics, University of Vienna, Vienna, Austria
    J Math Biol 58:939-78. 2009
    ..In both cases, every trajectory converges to an equilibrium, thus no cycling or complicated dynamics can occur...
  97. ncbi Mapping quantitative trait loci with epistatic effects
    Nengjun Yi
    Department of Botany and Plant Sciences, University of California, Riverside, CA 92521 0124, USA
    Genet Res 79:185-98. 2002
    ..This requires the reversible jump Markov chain Monte Carlo algorithm. The utility of the proposed method is demonstrated through analysis of simulation data...
  98. ncbi Polymorphism in the two-locus Levene model with nonepistatic directional selection
    Reinhard Burger
    Department of Mathematics, University of Vienna, Austria
    Theor Popul Biol 76:214-28. 2009
    ..If the favorable allele is (partially) dominant in its deme, more than 20% of all parameter combinations lead to a globally asymptotically stable, fully polymorphic equilibrium...
  99. pmc Epistasis in measured genotypes: Drosophila P-element insertions
    A G Clark
    Department of Biology, Pennsylvania State University, University Park 16802, USA
    Genetics 147:157-63. 1997
    ..Measured genotypes have been used in other contexts to quantify epistatic effects on phenotypic expression, and these results are also briefly reviewed...
  100. pmc RAD50 and RAD51 define two pathways that collaborate to maintain telomeres in the absence of telomerase
    S Le
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Genetics 152:143-52. 1999
    ..Thus RAD50 and RAD51 define two separate pathways that collaborate to allow cells to survive in the absence of telomerase...
  101. pmc Two survivor pathways that allow growth in the absence of telomerase are generated by distinct telomere recombination events
    Q Chen
    Department of Molecular Biology and Genetics, Graduate Program in Cell and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 21:1819-27. 2001
    ....

Research Grants62

  1. Novel Zebrafish Models to Study Toxicity of PCBs and Pesticides During Pregnancy
    Lisa Satterwhite; Fiscal Year: 2009
    ..AHR leads to down regulation of tbx5 followed by p53 mediated cell cycle arrest in the heart by using genetic epistasis and DNA microarray analysis...
  2. Regulation of Synapse Morphogenesis in Drosophila
    David L Van Vactor; Fiscal Year: 2013
    ..Moreover, genetic epistasis reveals that miR-8 is required for NMJ expansion induced by activation of a key presynaptic pathway that ..
  3. Identifying New Regulators of Leptin-Like Signaling in Drosophila Brain Neurons
    KAI G ZINN; Fiscal Year: 2013
    ..Analysis of genetic epistasis will be used to determine whether the regulators act upstream or downstream of the receptor, and if they ..
  4. Metabolic regulation of stem cell behavior and longevity
    David W Walker; Fiscal Year: 2013
    ..the mechanism by which dPGC-1 overexpression leads to lifespan extension will be examined by studying intestinal function in aging flies and conducting genetic epistasis experiments with previously characterized longevity pathways.
  5. Osteocalcin: the hormonal link between bone and reproduction
    Gerard Karsenty; Fiscal Year: 2013
    ..To use genetic epistasis to demonstrate that a putative osteocalcin receptor expressed on Leydig cells mediates osteocalcin function ..
  6. A lipophilic hormonal pathway regulating development and aging
    Adam Antebi; Fiscal Year: 2010
    ..Finally, we will order the genes within pathways by genetic epistasis and synergy, as well as by using phenotypic rescue by lipid extracts...
  7. Dissection of a Developmental Checkpoint That Preserves Regenerative Capacity
    ADRIAN J HALME; Fiscal Year: 2013
    ..b>Genetic epistasis experiments will be used to test the role of Eiger, the Drosophila TNF homologue, in producing the systemic ..
  8. Inositol Signaling in C. elegans Senescence and Diapause
    GARY B RUVKUN; Fiscal Year: 2010
    ..While many points of congruence have been identified, we know from genetic epistasis experiments that there are missing components...
  9. Influenza NS1: analysis of cellular targets and generation of peptide inhibitors
    MARGERY GAIL SMELKINSON; Fiscal Year: 2010
    ..This will be explored by performing genetic epistasis tests with Hh signaling components and targets...
  10. Genetic and genomic investigations of fat storage and metabolism in C. elegans
    Jennifer L Watts; Fiscal Year: 2013
    ..and their place in the genetic regulatory hierarchy will be explored by means of gene expression studies, genetic epistasis analysis, functional studies using RNA interference, and lipid analysis...
  11. In vivo analysis of the HS code
    Matthew Attreed; Fiscal Year: 2013
    ..Specifically, I will use synaptic function assays and genetic epistasis experiments to determine how HS motifs interact with cholinergic synaptic function...
  12. PI3K/Akt-mediated PDGFRalpha signaling in craniofacial development
    KATHERINE ANN FANTAUZZO; Fiscal Year: 2013
    ..the role of Akt phosphorylation targets in craniofacial development will be characterized in vivo through genetic epistasis experiments between PDGFR[unreadable] and target gene mutant mice...
  13. How Ephexin Signaling Promotes Neuronal Stability
    CARL ANDREW FRANK; Fiscal Year: 2012
    ..inhibition of target molecules, analyses of gene expression and protein localization, transgenic rescue, and genetic epistasis and pathway analyses...
  14. Genomic search for bone mass QTLs
    Hong Wen Deng; Fiscal Year: 2010
    ..We performed preliminary analyses for whole genome scan (WGS) and for genetic epistasis. Several genomics regions showing strong linkage to BMD were identified...
  15. Growth Factor Signaling and Craniofacial Development
    PHILIPPE M SORIANO; Fiscal Year: 2013
    ..b>Genetic epistasis experiments between PDGFRa and phosphorylation target mutants will be conducted to identify their role in ..
  16. Quantitative genetic analyses of conserved C. elegans signaling pathways
    Erik C Andersen; Fiscal Year: 2010
    ..In this study, I will use C. elegans quantitative genetics coupled with classical genetic epistasis to identify the genes of both major and modest effects on conserved TGF-beta and insulin pathways...
  17. Pigmentation-dependent melanosomal disease
    MICHAEL GARY ANDERSON; Fiscal Year: 2010
    ..We will test our hypothesis using a combination of genetic epistasis experiments that take advantage of existing Gpnmb mutant mouse strains and synchrotron based imaging ..
  18. Mechanisms controlling cell cycle exit upon terminal differentiation
    Laura A Buttitta; Fiscal Year: 2013
    ..I will also investigate the signaling pathways by which these genes are regulated, using genetic epistasis tools in both Drosophila and mammalian cells (Aim 3)...
  19. MULTIPLE SEVERE OBESITY RISK GENES IN UTAH PEDIGREES
    Steven Hunt; Fiscal Year: 2009
    ..Improvements in statistical modeling have led to increased published evidence of genetic epistasis and gender-specific effects, supporting the long-held view that obesity is a complex disease involving ..
  20. INDUCTIVE SIGNALING IN FOREGUT DEVELOPMENT
    Chin Chiang; Fiscal Year: 2003
    ..To accomplish these aims, we will conduct genetic epistasis experiments and perform extensive morphological and molecular analyses of the mutant foregut...
  21. Gs signaling in synaptic development and function
    Michael Forte; Fiscal Year: 2006
    ..2. Test Models of the Role of Gsa Signaling in NMJ Formation through Genetic Epistasis.The object of this aim is to test our revised model of NMJ formation by examining the functional ..
  22. Obesity and diabetes genetics and therapeutics in Caenorhabditis elegans.
    Alexander Soukas; Fiscal Year: 2009
    ..b>Genetic epistasis will identify which genes operate within known pathways or novel pathways regulating energy homeostasis...
  23. An E3 Ubiquitin Ligase Complex That Regulates C. elegans Developmental Timing
    Adam Antebi; Fiscal Year: 2009
    ..pattern and regulation will be determined and the position of dre-1in the heterochronic pathways revealed by genetic epistasis and synergy. 2. elucidate the E3 complex in which DRE-1 acts...
  24. Ras signaling in C.neoformans virulence and development
    J Alspaugh; Fiscal Year: 2002
    ..The roles of these proteins will be investigated by targeted gene disruption and genetic epistasis experiments...
  25. A systematic analysis of mir-34 function in C. elegans
    MOLLY C HAMMELL; Fiscal Year: 2010
    ..Finally, I will use genetic epistasis analysis to identify whether mir-34 is sufficient to regulate its identified targets or whether other ..
  26. FUNCTION AND REGULATION OF SHP-1 TYROSINE PHOSPHATASE
    Terry Woodford Thomas; Fiscal Year: 1999
    ..There are three Specific Aims. In Specific Aim l genetic epistasis experiments are proposed to further define the role of SHP-l in regulating leukocyte differentiation and ..
  27. Linking motorneuron fate and connectivity in Drosophila
    HEATHER BROIHIER; Fiscal Year: 2010
    ..we will identify the signaling pathway(s) regulating FoxO expression in motorneurons through molecular and genetic epistasis experiments. Matrix metalloproteinases (Mmps) comprise a large family of...
  28. Identification of new Wnt signaling components
    Kenneth Cadigan; Fiscal Year: 2006
    ..The molecular mechanism of Gam action in Wg signaling will be persued using genetic epistasis in flies and fly cell culture, identification of possible binding partners for the Gam protein and a ..
  29. CELL BIOLOGY AND PHYSIOLOGY OF GUSTATORY TRANSDUCTION
    CHARLES ZUKER; Fiscal Year: 2001
    ..a preparation suitable for physiological analysis and use electrophysiological recording together with genetic epistasis to localize the site of action of the defective genes...
  30. PROTEIN PHOSPHATASES IN YEAST SIGNAL TRANSDUCTION
    Haruo Saito; Fiscal Year: 2001
    ..The physiological substrate of PTC1 will be defined using genetic epistasis test and an in vitro assay system...
  31. Small Molecules Directing DA Neuron Differentiation
    Sheng Ding; Fiscal Year: 2006
    ..SAR) studies, affinity chromatography, genome-wide mRNA expression analysis, chemical and genetic epistasis, arrayed genome-wide cDNA and siRNA complementation, and various other structural, biochemical and cellular ..
  32. MOLECULAR BIOLOGY OF VISION
    CHARLES ZUKER; Fiscal Year: 2006
    ..Use genetic epistasis to localize the site of action of the defective genes. 4...
  33. ANALYSIS OF NEURAL DEVELOPMENT GENES IN DROSOPHILA
    LAUREN YAICH; Fiscal Year: 2000
    ..These gene will also be tested in genetic epistasis experiments with other known neural development genes to ascertain the precise positions that these genes ..
  34. Genetics Basis of Trauma Recovery
    Jason Moore; Fiscal Year: 2009
    ..abstract_text> ..
  35. GENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1
    Jason Moore; Fiscal Year: 2004
    ..This collaborative proposal provides a robust mechanism for highly focused translational research in the molecular genetics and biology of the role of the fibrinolytic system in arterial and cerebral thrombosis. ..
  36. Parallel Computer
    Jason Moore; Fiscal Year: 2004
    ..This resource will make it possible to carry out computationally intensive biomedical investigations otherwise not feasible thus significantly increasing the rate of scientific discovery in a variety of biomedical disciplines. ..
  37. A Mouse Model for Complex Human Diseases
    James Cheverud; Fiscal Year: 2009
    ..Backcrossing with SM/J will be used to narrow the QTL interval for strain loss and to produce a new strain, carrying the unusual phenotypes of SM/J without requiring enforced heterozygosity at the agouti locus. ..
  38. GENETIC VARIATION IN MURINE LONG BONE GROWTH AND DEVELOPMENT
    James M Cheverud; Fiscal Year: 2010
    ..The outcome of these experiments will be a better understanding of the genetic, molecular, and cellular processes responsible for variation in limb growth with consequences for our understanding of pathologies of growth. ..
  39. GENE INTERACTION FOR BODY WEIGHT COMPONENTS IN MICE
    James Cheverud; Fiscal Year: 2002
    ..In addition to positional cloning of the QTLs, congenic strains will be formed for each QTL and will be tested, along with the LGxSM recombinant inbred strains for a variety of obesity-related traits. ..
  40. Genetic Environmental Relationship Between Bone Obesity and Leptin in Mice
    James M Cheverud; Fiscal Year: 2010
    ..This project will identify novel genes and physiological pathways affecting osteoporosis and examine how genetic and environmentally-based obesity affects bone mass, morphology and biomechanical function. ..
  41. Genetics Basis of Dietary Obesity in Mice
    James Cheverud; Fiscal Year: 2009
    ..These studies will increase our knowledge of the important physiological effects of dietary fat, including the genetic variants responsible for individual variations in response to a high fat diet. ..
  42. Viral evolution:mutational effects and interactions
    CHRISTINA BURCH; Fiscal Year: 2007
    ..abstract_text> ..
  43. SURVIVAL MODELS FOR GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2006
    ..To illustrate our methodologic work, we will draw examples from the CFRBCCS and other studies the genetic epidemiology of cancer in the USC Department of Preventive Medicine. ..
  44. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2006
    ....
  45. Genetic Predictors of Incident CVD
    Sharon Kardia; Fiscal Year: 2005
    ..abstract_text> ..
  46. Evolutionary genomics of new Drosophila genes
    DAVEN PRESGRAVES; Fiscal Year: 2004
    ..The methods developed will be applicable in comparative analysis of other genomes, including those of humans and their primate relatives. ..
  47. GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS
    Sharon Kardia; Fiscal Year: 2004
    ..The resulting synthesis of ideas and amassed data permits rigorous hypothesis testing not otherwise possible and will hasten understanding of the previously elusive genetic variation responsible for disease risk. ..
  48. Novel approaches in linkage analysis for complex traits
    Mariza de Andrade; Fiscal Year: 2003
    ..No new data will be collected for this grant proposal. The application clearly fits the goal of this NHLBI grant program since it will explore new approaches using an existing data set collected through NHLBI support. ..
  49. COMPUTATIONAL METHODS IN GENETIC EPIDEMIOLOGY
    Duncan Thomas; Fiscal Year: 2003
    ..Efficient Estimating Equations (EEE) methods for semi-parametric analysis MCMC methods for larger pedigrees than are currently feasible. ..
  50. Quantitative methods for genetic linkage heterogeneity
    Daniel Schaid; Fiscal Year: 2008
    ..Aim 3. User-friendly software: User-friendly software that implements the proposed methods, including well-documented procedures and examples of their usage, will be provided free to the scientific community. ..
  51. Immunoglobulin Allotypes in Hepatitis C Virus Infection
    JANARDAN PANDEY; Fiscal Year: 2008
    ..Results of this investigation will advance our understanding of the role of host genetic factors in clearance and persistence of hepatitis C virus infection. ..
  52. Genomic Predictors of Arteriosclerosis in Hypertensives
    Sharon Kardia; Fiscal Year: 2009
    ..End of Abstract) ..
  53. Evolutionary Genomics of Anti-Malaria Genes in Mosquito
    Brian P Lazzaro; Fiscal Year: 2010
    ..Evolutionary patterns in mosquito defense genes will be used to identify proteins that coevolve with malaria parasites. This work may suggest genetic targets that could be manipulated to limit malaria transmission. ..
  54. QUANTITATIVE ASSOCIATION METHODS FOR GENE MAPPING
    Daniel Schaid; Fiscal Year: 2001
    ..The advantages of this proposed research, over those currently used to identify and characterize genes of complex diseases, are that it will offer a more powerful and flexible method to find these types of genes. ..
  55. DESIGN AND ANALYSIS OF GENOME-WIDE ASSOCIATION STUDIES
    Duncan Thomas; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  56. Dissection of Muscle Weight QTL Via Congenic Strains
    Arimantas Lionikas; Fiscal Year: 2008
    ..3) Using a bioinformatics approach, search for candidate genes within the region of Chr 9 defined by congenic strain analysis with the potential to influence muscle weight. [unreadable] [unreadable] [unreadable]..
  57. QUANITITATIVE TRAIT LOCI FOR CHEMOSENSATION
    Patrick Phillips; Fiscal Year: 2002
    ..e., difference in mean chemotactic behavior between the two F1 hybrid classes) will be tested to determine whether naturally occurring alleles interact with the candidate locus mutations. ..
  58. Spatio-Temporal Epidemiology: Methods and Applications
    Jonathan Wakefield; Fiscal Year: 2008
    ..S. cancer incidence and mortality data, and Washington State small-area cancer incidence data. Developed methods will be made available to researchers via implementation within freely-available software. ..
  59. QTL mapping for genes regulating apoptosis capacity
    Jianfeng Xu; Fiscal Year: 2010
    ..Our proposal describes a novel and efficient approach to identify apoptosis genes that are critical in cancer susceptibility. ..
  60. IBD MAPPING & PATTERN OF HUMAN MEIOTIC RECOMBINATION
    Vivian Cheung; Fiscal Year: 2008
    ..It will also give insights into the pattern of human meiotic recombination, a key process that contributes to genetic diversity and to risk of non-disjunction. ..
  61. MECHANISM & FUNCTIONS OF ICH-3 IN APOPTOSIS/INFLAMMATION
    Junying Yuan; Fiscal Year: 2001
    ..These works will have direct implication in control of apoptosis in normal and inflammatory conditions. ..
  62. Gene-Environment Interactions and Stroke Susceptibility
    Myriam Fornage; Fiscal Year: 2004
    ..We will also identify and characterize DNA variation in a panel of selected stroke-candidate human genes and test whether variation in these genes is associated with risk of developing a stroke in the ARIC sample. ..