Genomes and Genes
enzymologic gene expression regulation
Summary: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
Publications334 found, 100 shown here
- GAP1, the general amino acid permease gene of Saccharomyces cerevisiae. Nucleotide sequence, protein similarity with the other bakers yeast amino acid permeases, and nitrogen catabolite repressionJ C Jauniaux
Laboratoire de Microbiologie, Faculte des Sciences, Universite Libre de Bruxelles, Belgium
Eur J Biochem 190:39-44. 1990..J. Biochem. 133, 135-139]. Northern analysis of GAP1-specific transcripts in wild-type and in mutant strains is in agreement with these views and indicates that nitrogen catabolite repression of GAP1 synthesis occurs at the RNA level...
- Disease resistance and abiotic stress tolerance in rice are inversely modulated by an abscisic acid-inducible mitogen-activated protein kinaseLizhong Xiong
Department of Plant Pathology and Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, Arkansas 72701, USA
Plant Cell 15:745-59. 2003..These results strongly suggest that OsMAPK5 can positively regulate drought, salt, and cold tolerance and negatively modulate PR gene expression and broad-spectrum disease resistance...
- Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoterL M Guzman
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
J Bacteriol 177:4121-30. 1995..We have exploited the tight regulation of the PBAD promoter to study the phenotypes of null mutations of essential genes and explored the use of pBAD vectors as an expression system...
- An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell linesJennifer D Davidson
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA
Cancer Res 64:3761-6. 2004..The results from this study indicate that the level of RRM1 may affect gemcitabine response. Furthermore, RRM1 may serve as a biomarker for gemcitabine response...
- Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell deathY Suzuki
Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute, Wako City, Saitama 351 0198, Japan
Proc Natl Acad Sci U S A 98:8662-7. 2001..These results demonstrate that the ubiquitin-protein ligase activity of XIAP promotes the degradation of caspase-3, which enhances its anti-apoptotic effect...
- Nitric oxide synthases: structure, function and inhibitionW K Alderton
In Vitro Pharmacology Department, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK
Biochem J 357:593-615. 2001..Highly selective inhibitors of iNOS versus eNOS and neuronal NOS have been identified and some of these have potential in the treatment of a range of inflammatory and other conditions in which iNOS has been implicated...
- Overexpression of polygalacturonase in transgenic apple trees leads to a range of novel phenotypes involving changes in cell adhesionRoss G Atkinson
The Horticulture and Food Research Institute of New Zealand, Mount Albert Research Centre, Private Bag 92 169, Auckland, New Zealand
Plant Physiol 129:122-33. 2002..The modification of apple trees by a single PG gene has offered a new and unexpected perspective on the role of pectin and cell wall adhesion in leaf morphology and stomatal development...
- Regulation of the expression of inducible nitric oxide synthaseHartmut Kleinert
Department of Pharmacology, Johannes Gutenberg University, D 55101 Mainz, Germany
Biol Chem 384:1343-64. 2003..The induction of iNOS can be inhibited by a wide variety of immunomodulatory compounds acting at the transcriptional levels and/or post-transcriptionally...
- Estrogen directly activates AID transcription and functionSiim Pauklin
DNA Editing Laboratory, Cancer Research UK, Clare Hall Laboratories, South Mimms, EN6 3LD, England, UK
J Exp Med 206:99-111. 2009..We therefore suggest that estrogen-induced autoimmunity and oncogenesis may be derived through AID-dependent DNA instability...
- Regulation of matrix metalloproteinase expression in tumor invasionJ Westermarck
MediCity Research Laboratory, Department of Medical Biochemistry, University of Turku, Finland
FASEB J 13:781-92. 1999....
- Beta-fructofuranosidase genes of the silkworm, Bombyx mori: insights into enzymatic adaptation of B. mori to toxic alkaloids in mulberry latexTakaaki Daimon
Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo, Japan
J Biol Chem 283:15271-9. 2008..This anomalous presence of the beta-fructofuranosidase gene in the B. mori genome may partly explain why the silkworm can circumvent the mulberry's defense system...
- Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseasesS Lorenzl
Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street Room A 501, New York, NY 10021, USA
J Neurol Sci 207:71-6. 2003..These findings show that TIMPs are elevated in the CSF of patients with neurodegenerative diseases suggesting a potential role of these endogenous inhibitors of matrix metalloproteinases in neurodegenerative diseases...
- Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potentialCristina Angeloni
Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
J Agric Food Chem 57:5615-22. 2009....
- Localization of rat cytochrome P450 in various tissues and comparison of arachidonic acid metabolism by rat P450 with that by human P450 orthologsSusumu Imaoka
Nanobiotechnology Research Center and Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, Hyogo, Japan
Drug Metab Pharmacokinet 20:478-84. 2005..A systematic analysis of P450 expression in various tissues and of its catalytic property may provide valuable information on the physiological roles of P450s in each tissue...
- Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma modelWilliam R Henderson
Center for Allergy and Inflammation, Department of Medicine, University of Washington, Seattle, WA 98109, USA
J Exp Med 204:865-77. 2007..These data direct attention to sPLA(2)-X as a novel therapeutic target for asthma...
- 15-Hydroxyprostaglandin dehydrogenase is down-regulated in colorectal cancerMichael G Backlund
Department of Medicine, Cell and Developmental Biology, Vanderbilt University Medical Center and the Vanderbilt Ingram Cancer Center, Nashville, Tennessee 37232 6838, USA
J Biol Chem 280:3217-23. 2005..In summary, these results suggest a novel tumor suppressive role for 15-PGDH due to loss of expression during colorectal tumor progression...
- Transcriptional regulation of the human DNA polymerase delta catalytic subunit gene POLD1 by p53 tumor suppressor and Sp1B Li
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, New York 10595, USA
J Biol Chem 276:29729-39. 2001..Finally, gel shift assays suggested that p53 competes with Sp1 protein for binding to the P4 sequence of the POLD1 promoter...
- Matrix metalloproteinases: a tail of a frog that became a princeConstance E Brinckerhoff
Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Nat Rev Mol Cell Biol 3:207-14. 2002..Structural, molecular and biochemical approaches have subsequently contributed to piecing together the puzzle of how MMPs work, and how they contribute to various disease processes...
- The mycosins of Mycobacterium tuberculosis H37Rv: a family of subtilisin-like serine proteasesG D Brown
Department of Medical Biochemistry MRC Centre for Molecular and Cellular Biology, University of Stellenbosch, 7505, Tygerberg, South Africa
Gene 254:147-55. 2000..Mycosin-2 was modified by cleavage in all three mycobacterial species. The multiplicity and constitutive expression of these proteins suggests that they have an important role in the biology of M. tuberculosis...
- The glyoxylate cycle is required for fungal virulenceM C Lorenz
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Massachusetts 02142, USA
Nature 412:83-6. 2001....
- CREB regulates hepatic gluconeogenesis through the coactivator PGC-1S Herzig
Peptide Biology Laboratories, Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, California 92037 1002, USA
Nature 413:179-83. 2001..Fasting hyperglycaemia is strongly correlated with type II diabetes, so our results suggest that the activation of PGC-1 by CREB in liver contributes importantly to the pathogenesis of this disease...
- Mitogen-activated protein kinase cascades and regulation of gene expressionB Su
Department of Immunology, University of Texas, MD Anderson Cancer Center, Houston 77030, USA
Curr Opin Immunol 8:402-11. 1996..An emerging topic of great interest is the basis for specificity in the activation of individual MAPKs and their ability to recognize their substrates...
- Identification of chondroitin sulfate glucuronyltransferase as chondroitin synthase-3 involved in chondroitin polymerization: chondroitin polymerization is achieved by multiple enzyme complexes consisting of chondroitin synthase family membersTomomi Izumikawa
Department of Biochemistry, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
J Biol Chem 283:11396-406. 2008..Based on these results, we renamed CSGlcA-T chondroitin synthase-3 (ChSy-3)...
- A maize (E)-beta-caryophyllene synthase implicated in indirect defense responses against herbivores is not expressed in most American maize varietiesTobias G Köllner
Max Planck Institute for Chemical Ecology, D 07745 Jena, Germany
Plant Cell 20:482-94. 2008..We argue that the (E)-beta-caryophyllene defense signal was lost during breeding of the North American lines and that its restoration might help to increase the resistance of these lines against agronomically important pests...
- Activation of gibberellin biosynthesis and response pathways by low temperature during imbibition of Arabidopsis thaliana seedsYukika Yamauchi
Plant Science Center, RIKEN, Institute of Physical and Chemical Research, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
Plant Cell 16:367-78. 2004....
- A nonsense mutation in a cinnamyl alcohol dehydrogenase gene is responsible for the Sorghum brown midrib6 phenotypeScott E Sattler
Grain, Forage, and Bioenergy Research Unit, United States Department of Agriculture Agricultural Research Service, Nebraska, USA
Plant Physiol 150:584-95. 2009..These differences include His-57, which is unique to Bmr6 and other grass CADs. In summary, Bmr6 encodes the major CAD protein involved in lignin synthesis in sorghum, and the bmr6 mutant is a null allele...
- The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levelsPascale Daran-Lapujade
Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628 BC, Delft, The Netherlands
Proc Natl Acad Sci U S A 104:15753-8. 2007..Within the 50-20% hierarchical regulation of fluxes, transcription played a minor role, whereas regulation of protein synthesis or degradation was the most important. These also contributed to 75-100% of the regulation of protein levels...
- Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxinsTetsuya Okuda
Department of Biochemistry II, Nagoya University School of Medicine, Tsurumai, Showa Ku, Nagoya 466 0065, Japan
J Biol Chem 281:10230-5. 2006..The lethal kinetics were similar regardless of lipopolysaccharide elimination in VT preparation, suggesting that basal Gb3/CD77 levels are sufficient for lethal effects of VTs...
- Maintenance of differentiated phenotype of articular chondrocytes by protein kinase C and extracellular signal-regulated protein kinaseYoung Mee Yoon
National Research Laboratory, Department of Life Science, Kwangju Institute of Science and Technology, Kwangju 500 712, Korea
J Biol Chem 277:8412-20. 2002....
- The PINOID protein kinase regulates organ development in Arabidopsis by enhancing polar auxin transportR Benjamins
Institute of Molecular Plant Sciences, Leiden University, Clusius Laboratory, Wassenaarseweg 64, Leiden, The Netherlands
Development 128:4057-67. 2001..We propose that PINOID is involved in the fine-tuning of polar auxin transport during organ formation in response to local auxin concentrations...
- Heterologous expression of four glutathione transferase genes genetically linked to a major insecticide-resistance locus from the malaria vector Anopheles gambiaeFederica Ortelli
Liverpool School of Tropical Medicine, Vector Biology Research Group, Pembroke Place, Liverpool L3 5QA, UK
Biochem J 373:957-63. 2003..Only GSTE2-2 was able to metabolize DDT. Western blots using antibodies raised against these GSTs indicated that the expression of GSTE2-2 is elevated in a DDT-resistant strain of A. gambiae...
- Rho-family GTPases: it's not only Rac and Rho (and I like it)Krister Wennerberg
Department of Pharmacology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7295, USA
J Cell Sci 117:1301-12. 2004..Newer members of the family possess additional sequence elements beyond the GTPase domain, which suggests they exhibit yet other mechanisms of regulation...
- Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1Eiji Furuta
Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, Springfield, Illinois 62794 9626, USA
Cancer Res 68:1003-11. 2008....
- Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunctionMarina R Bergman
Department of Medicine, San Francisco Department of Veterans Affairs Medical Center University of California, San Francisco, California 94121, USA
Am J Physiol Heart Circ Physiol 292:H1847-60. 2007..5 +/- 1.5 vs. MMP 4.7 +/- 2.0; P = 0.016). Expression of active MMP-2 is sufficient to induce severe ventricular remodeling and systolic dysfunction in the absence of superimposed injury...
- Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden deathImran N Mungrue
Heart and Stroke Richard Lewar Centre of Excellence, University of Toronto, Toronto, Ontario, Canada
J Clin Invest 109:735-43. 2002..This dramatic cardiac phenotype was rescued by specific attenuation of transgene activity. These data implicate cardiomyocyte iNOS overexpression as sufficient to cause cardiomyopathy, bradyarrhythmia, and sudden cardiac death...
- Histone deimination antagonizes arginine methylationGraeme L Cuthbert
Gurdon Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
Cell 118:545-53. 2004..The recruitment of PADI4 coincides with deimination of the histone H3 N-terminal tail. These results define deimination as a novel mechanism for antagonizing the transcriptional induction mediated by arginine methylation...
- The eto1, eto2, and eto3 mutations and cytokinin treatment increase ethylene biosynthesis in Arabidopsis by increasing the stability of ACS proteinHyun Sook Chae
Department of Biology, University of North Carolina, Chapel Hill, North Carolina 27599 3280, USA
Plant Cell 15:545-59. 2003..These results suggest that an important mechanism by which ethylene biosynthesis is controlled is the regulation of the stability of ACS, mediated at least in part through the C-terminal domain...
- F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complexD Skowyra
Verna and Marrs McLean Department of Biochemistry, Baylor College of Medicine, Houston, Texas 77030, USA
Cell 91:209-19. 1997..SCF complexes couple protein kinase signaling pathways to the control of protein abundance...
- Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxiaP J Lee
Division of Pulmonary and Critical Care, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
J Biol Chem 272:5375-81. 1997..Taken together, these data demonstrate that hypoxia induces HO-1 expression in animal tissues and cell cultures and implicate HIF-1 in this response...
- The metabolism of proline, a stress substrate, modulates carcinogenic pathwaysJames M Phang
Laboratory of Comparative Carcinogenesis, Center for Cancer Research, Building 538, Room 115, NCI Frederick, Frederick, MD 21702, USA
Amino Acids 35:681-90. 2008..In a manner analogous to autophagy, this proline-dependent process for bioenergetics from collagen in extracellular matrix can be designated "ecophagy"...
- A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cellsW Tirasophon
Department of Biological Chemistry and the Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
Genes Dev 12:1812-24. 1998..These results demonstrate that hIre1p is an essential proximal sensor of the unfolded protein response pathway in mammalian cells...
- A gene encoding a mitogen-activated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and water stress in Arabidopsis thalianaT Mizoguchi
Laboratory of Plant Molecular Biology, Institute of Physical and Chemical Research RIKEN, Tsukuba Life Science Center, Ibaraki, Japan
Proc Natl Acad Sci U S A 93:765-9. 1996....
- p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosisS Perwez Hussain
Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892 4255, USA
Cancer Res 64:2350-6. 2004..These results identify a novel mechanism of p53-dependent apoptosis in which p53-mediated up-regulation of MnSOD and GPx, but not CAT, produces an imbalance in antioxidant enzymes and oxidative stress...
- Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeuticsRichard S Jope
Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Sparks Center 1057, 1720 Seventh Avenue South, Birmingham, AL 35294 0017, USA
Neurochem Res 32:577-95. 2007..Thus, GSK3 may contribute not only to primary pathologies in these diseases, but also to the associated inflammation, suggesting that GSK3 inhibitors may have multiple effects influencing these conditions...
- Plant biotin-containing carboxylasesBasil J Nikolau
Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA
Arch Biochem Biophys 414:211-22. 2003..This minireview summarizes the recent developments in our understanding of the structure, regulation, and metabolic functions of these proteins in plants...
- Isochorismate synthase is required to synthesize salicylic acid for plant defenceM C Wildermuth
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 414:562-5. 2001..Here we show, by cloning and characterizing an Arabidopsis defence-related gene (SID2) defined by mutation, that SA is synthesized from chorismate by means of ICS, and that SA made by this pathway is required for LAR and SAR responses...
- Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptorsK J Sales
Department of Medical Biochemistry, University of Cape Town Medical School, Observatory, Cape Town 7925, South Africa
J Clin Endocrinol Metab 86:2243-9. 2001....
- A conserved family of prolyl-4-hydroxylases that modify HIFR K Bruick
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3 124, Dallas, TX 75390 9152, USA
Science 294:1337-40. 2001..These findings indicate that HPH is an essential component of the pathway through which cells sense oxygen...
- The oxidative pentose phosphate pathway: structure and organisationNicholas J Kruger
Department of Plant Sciences, University of Oxford, South Parks Road, Oxford OX1 3RB, UK
Curr Opin Plant Biol 6:236-46. 2003..These strategies make it possible to quantify flux through metabolic networks and to discriminate between pathways of carbohydrate oxidation in the cytosol and plastids...
- Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damageAmira Zaky
Department of Biochemistry and Molecular Biology, Sealy Center for Molecular Medicine, University of Texas Medical Branch, TX 77555, Galveston, USA
Nucleic Acids Res 36:1555-66. 2008..Taken together, our results demonstrate that WTp53 is a negative regulator of APE1 expression, so that repression of APE1 by p53 could provide an additional pathway for p53-dependent induction of apoptosis in response to DNA damage...
- Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosensitized miceNilda M Munoz
Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, IL 60637, USA
J Immunol 179:4800-7. 2007..Our data demonstrate that gVPLA2 is a critical messenger enzyme in the development of AHR and regulation of cell migration during immunosensitization by a pathway that is independent of group IVa phospholipase A2...
- Telomeres shorten while Tert expression increases during ageing of the short-lived fish Nothobranchius furzeriNils Hartmann
Leibniz Institute for Age Research Fritz Lipmann Institute, Beutenbergstrasse 11, 07745 Jena, Germany
Mech Ageing Dev 130:290-6. 2009..We further conclude that the extremely short lifespan of the GRZ strain is not caused by diminished telomerase activity or accelerated telomere shortening...
- Purple acid phosphatases of Arabidopsis thaliana. Comparative analysis and differential regulation by phosphate deprivationDongping Li
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
J Biol Chem 277:27772-81. 2002....
- Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT)M Wick
Bayer AG, Central Research Division, Department of Molecular Biology, D 51368, Leverkusen, Germany
Gene 232:97-106. 1999..Altogether, these results provide the basis for more detailed studies on the regulation of telomerase activity in normal and cancer cells, and may lead to the development of new cancer therapies...
- Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissuesEri Arai
Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
Int J Cancer 119:288-96. 2006..Regional DNA hypermethylation may be associated with renal tumorigenesis from a precancerous condition to malignant progression and become a predictor of patient prognosis...
- 15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancerIdo Wolf
Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, Los Angeles, CA 90048, USA
Cancer Res 66:7818-23. 2006..Our results indicate for the first time that 15-PGDH may be a novel tumor suppressor gene in breast cancer, and suggest that this enzyme can modulate the ER pathway...
- Identification of a promoter region responsible for the senescence-specific expression of SAG12Y S Noh
Department of Biochemistry, University of Wisconsin, Madison 53706 1544, USA
Plant Mol Biol 41:181-94. 1999..Extracts from young and senescent Arabidopsis leaves contain factors that exhibit differential binding to the senescence-responsive promoter element...
- Regulation of acetyl-CoA carboxylaseR W Brownsey
Department of Biochemistry and Molecular Biology and The Diabetes Research Group of the Life Sciences Institute, The University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3
Biochem Soc Trans 34:223-7. 2006..This review traces the path and implications of studies initiated with Dick Denton in Bristol in the late 1970s, through to current proteomic and other approaches that have been consistently challenging and immensely rewarding...
- A single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter influences amnion cell MMP-1 expression and risk for preterm premature rupture of the fetal membranesToshio Fujimoto
Center for Research on Reproduction and Women s Health, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 277:6296-302. 2002..We conclude that the 2G allele has stronger promoter activity in amnion cells, that it confers increased responsiveness of amnion cells to stimuli that induce MMP-1, and that this polymorphism contributes to the risk of PPROM...
- Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytesAbdelhamid Liacini
Département de Médecine and Centre de Recherche du Centre Hospitalier de l Université de Montréal, Hôpital Notre Dame du CHUM, 1560 Sherbrooke Est, Montreal, Quebec, Canada H2L 4M1
Matrix Biol 21:251-62. 2002..Inhibition of IL-1 signal transduction by these agents could be useful for reducing cartilage resorption by MMPs in arthritis...
- Pectin: cell biology and prospects for functional analysisW G Willats
Centre for Plant Sciences, University of Leeds, UK
Plant Mol Biol 47:9-27. 2001....
- In support of fatty acid synthase (FAS) as a metabolic oncogene: extracellular acidosis acts in an epigenetic fashion activating FAS gene expression in cancer cellsJavier A Menendez
Department of Medicine, Breast Cancer Translational Research Laboratory, Evanston Northwestern Healthcare Research Institute, Evanston, Illinois 60201, USA
J Cell Biochem 94:1-4. 2005..These findings, altogether, support the "metabolic oncogene" theory for FAS overexpression in cancer cells...
- The Halloween genes code for cytochrome P450 enzymes mediating synthesis of the insect moulting hormoneK F Rewitz
Department of Life Sciences and Chemistry, Roskilde University, P O Box 260, 4000 Roskilde, Denmark
Biochem Soc Trans 34:1256-60. 2006..The results indicate that these Halloween genes are transcriptionally regulated to support the high biosynthetic activity that produces the cyclic ecdysteroid pulses triggering moulting...
- Biochemical and molecular characterization of AtPAP26, a vacuolar purple acid phosphatase up-regulated in phosphate-deprived Arabidopsis suspension cells and seedlingsVasko Veljanovski
Department of Biology, Queen s University, Kingston, Ontario, Canada K7L 3N6
Plant Physiol 142:1282-93. 2006..As AtPAP26 also exhibited alkaline peroxidase activity, a potential additional role in the metabolism of reactive oxygen species is discussed...
- Decreased expression of cyclic adenosine monophosphate-regulated aldose reductase (AKR1B1) is associated with malignancy in human sporadic adrenocortical tumorsAnne Marie Lefrançois-Martinez
Unité Mixte de Recherche 6547 CNRS Université Blaise Pascal Clermont II, Génétique des Eucaryotes et Endocrinologie Moléculaire, Complexe Universitaire des Cézeaux, 63177 Aubiere, France
J Clin Endocrinol Metab 89:3010-9. 2004..This might take part in adrenal tumorigenesis and could be investigated as a marker of malignancy for the diagnosis of adrenal tumors...
- Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survivalShahab Uddin
King Fahad National Center for Children s Cancer and Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
Blood 108:4178-86. 2006..In multivariate analysis, this correlation was no longer significant. Altogether, these results suggest that the PI3K/AKT pathway may be a potential target for therapeutic intervention in DLBCL...
- MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivoH Sun
Cold Spring Harbor Laboratory, New York 11724 2208
Cell 75:487-93. 1993..The mutant 3CH134 protein also forms a physical complex with the phosphorylated form of p42MAPK. These findings suggest that 3CH134 is a physiological MAP kinase phosphatase; we propose the name MKP-1 for this phosphatase...
- Harpin induces activation of the Arabidopsis mitogen-activated protein kinases AtMPK4 and AtMPK6R Desikan
Centre for Research in Plant Science, Faculty of Applied Sciences, University of the West of England, Coldharbour Lane, Bristol BS16 1QY, United Kingdom
Plant Physiol 126:1579-87. 2001..These data suggest that harpin activates several signaling pathways, one leading to stimulation of the oxidative burst and others leading to the activation of AtMPK4 or AtMPK6...
- Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling developmentManuel Rodriguez-Concepcion
Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, 08028 Barcelona, Spain
Plant Cell 16:144-56. 2004....
- Down-regulation of caffeic acid o-methyltransferase in maize revisited using a transgenic approachJoel Piquemal
Signaux et Messages Cellulaires chez les Vegetaux, Unite Mixte de Recherche, Centre National de la Recherche Scientifique Université Paul Sabatier, Pole de Biotechnologie Vegetale, Castanet Tolosan, France
Plant Physiol 130:1675-85. 2002..To our knowledge, this is the first time that an AS strategy has been applied to modify lignin biosynthesis in a grass species...
- Enhancement of stress tolerance in transgenic tobacco plants overexpressing Chlamydomonas glutathione peroxidase in chloroplasts or cytosolKazuya Yoshimura
Advanced Life Science, Graduate School, Kinki University, 3327 204 Nakamachi, Nara 631 8505, Japan
Plant J 37:21-33. 2004....
- Cyclooxygenase isozymes and their gene structures and expressionTadashi Tanabe
Department of Pharmacology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
Prostaglandins Other Lipid Mediat 68:95-114. 2002..Moreover, MAPK signaling pathways are involved in regulating COX-2 gene expression at the post-transcriptional level...
- Transcriptional regulation of a rice mitogen-activated protein kinase gene, OsMAPK4, in response to environmental stressesShin Feng Fu
Department of Biology, National Cheng Kung University, No 1 University Road 701, Tainan, Taiwan
Plant Cell Physiol 43:958-63. 2002..These results suggest that this OsMAPK4 functions not only in developmental programs but also in stress-signaling pathways...
- The oncogene phosphatidylinositol 3'-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinomaLin Zhang
Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
Cancer Res 63:4225-31. 2003....
- Decreased histone deacetylase activity in chronic obstructive pulmonary diseaseKazuhiro Ito
Airway Disease Section, National Heart and Lung Institute, Imperial College, London, United Kingdom
N Engl J Med 352:1967-76. 2005..HDAC is a key molecule in the repression of production of proinflammatory cytokines in alveolar macrophages...
- Function of a mitogen-activated protein kinase pathway in N gene-mediated resistance in tobaccoHailing Jin
Department of Plant and Microbial Biology, University of California, Berkeley and Plant Gene Expression Center, USDA ARS, 800 Buchanan St, Albany, CA 94710, USA
Plant J 33:719-31. 2003....
- Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cellsMin Hyuk Yoo
Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 281:13005-8. 2006..These observations provide direct evidence that the reduction of TR1 levels in malignant cells is antitumorigenic and suggest that the enzyme is a prime target for cancer therapy...
- Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapyDineo Khabele
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Meharry Medical College, Nashville, Tennessee 37208, USA
Cancer Biol Ther 6:795-801. 2007..Taken together, the present studies offer several novel findings that have direct relevance for the strategic use of inhibitors that target Class I HDACs, particularly HDAC3, in the treatment of ovarian cancer...
- Tumor-specific activation of human telomerase reverses transcriptase promoter activity by activating enhancer-binding protein-2beta in human lung cancer cellsWu Guo Deng
Section of Thoracic Molecular Oncology, Department of Thoracic and Cardiovascular Surgery, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 282:26460-70. 2007..Our results demonstrate the tumor-specific activation of the hTERT promoter by AP-2beta and imply the potential of AP-2beta as a novel tumor marker or a cancer therapeutic target...
- Salt-induced expression of the vacuolar H+-ATPase in the common ice plant is developmentally controlled and tissue specificD Golldack
Department of Physiology and Biochemistry of Plants, Faculty of Biology, University of Bielefeld, D-33501 Bielefeld, Germany
Plant Physiol 125:1643-54. 2001....
- Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by RasC Song
Department of Physiology II, Kobe University School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
J Biol Chem 276:2752-7. 2001..These results indicate that Ras directly regulates phosphoinositide breakdown through membrane targeting of PLCepsilon...
- Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerabilityXiaodong Bao
Higuchi Biosciences Center, Department of Pharmacology and Toxicology, and Life Span Studies Institute, University of Kansas, Lawrence, KS 66047, USA
J Neurosci 29:13929-44. 2009..The Glud1 mouse might be a useful model for the effects of lifelong excess synaptic Glu release on CNS neurons and for age-associated neurodegenerative processes...
- Caspase 3 expression in benign prostatic hyperplasia and prostate carcinomaS A Boran
Department of Surgery, Mater Misericordiae Hospital, University College Dublin, Conway Institute of Biomolecular and Biomedical Research, Dublin, Ireland
Prostate 47:183-8. 2001..CONCLUSIONS: Altered caspase 3 expression may represent an additional mechanism of apoptotic resistance to androgen ablation. Prostate 47:183-188, 2001...
- Histone acetylases and deacetylases in cell proliferationT Kouzarides
Wellcome CRC Institute, Department of Pathology, Tennis Court Road, Cambridge CB2 1QR, UK
Curr Opin Genet Dev 9:40-8. 1999..Furthermore, accumulating evidence suggests that deregulation of acetylase and deacetylase activity plays a causative role in the generation of cancer...
- FLEXIBLE CULM 1 encoding a cinnamyl-alcohol dehydrogenase controls culm mechanical strength in riceXiangjun Li
National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan 430070, China
Plant Mol Biol 69:685-97. 2009..Our results indicated that FC1 plays an important role in the biosynthesis of lignin and the control of culm strength in rice...
- Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brainS Avraham
Deaconess Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 270:27742-51. 1995..The structural features of RAFTK suggest that it is a member of the focal adhesion kinase gene family and may participate in signal transduction in human megakaryocytes and brain as well as in other cell types...
- A role for poly(ADP-ribose) polymerase in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expressionC Nirodi
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
J Biol Chem 276:9366-74. 2001..Furthermore, 3-aminobenzamide, an inhibitor of PARP-specific ADP-ribosylation, inhibits CXCL1 promoter activity and reduces levels of CXCL1 mRNA. The data point to the possibility that PARP may be a coactivator of CXCL1 transcription...
- c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanismS R Eberhardy
University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
J Biol Chem 276:48562-71. 2001..In summary, our results suggest that c-Myc activates transcription of cad by stimulating promoter clearance and elongation, perhaps via recruitment of P-TEFb...
- Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6/1 human multiple myeloma cells increases cell proliferationDavid R Hodge
Laboratory of Molecular Immunoregulation, Cytokine Molecular Mechanisms Section, Center for Cancer Research, The National Cancer Institute at Frederick, Frederick, MD 21702, USA
Cancer Biol Ther 4:585-92. 2005..Infection of KAS 6/1 cells with a recombinant adenovirus carrying the MnSOD cDNA reduced the cell proliferation rate by approximately one-half, confirming the detrimental effects of epigenetic silencing of SOD-2 expression...
- The nitric oxide-cGMP pathway may mediate communication between sensory afferents and projection neurons in the antennal lobe of Manduca sextaA Nighorn
Arizona Research Laboratories, Division of Neurobiology, University of Arizona, Tucson, Arizona 85721, USA
J Neurosci 18:7244-55. 1998..The expression patterns of these genes suggest that the NO-sGC signaling system may play a role in mediating communication between olfactory receptor neurons and projection neurons in the glomeruli of the antennal lobe...
- Expression pattern and secretion of human and chicken heparanase are determined by their signal peptide sequenceO Goldshmidt
Department of Oncology, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel
J Biol Chem 276:29178-87. 2001....
- The role of calcium and calcium/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesisEva R Chin
Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Eastern Point Rd, MS8220 3120, Groton, CT 06340, USA
Proc Nutr Soc 63:279-86. 2004..Future studies will be important in determining whether insights from the adaptational response of muscle to increased loads will provide pharmacological approaches for increasing muscle strength or endurance to counter muscle wasting...
- Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICES Wang
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 92:501-9. 1998..Our data suggest that caspase-11 is a component of ICE complex and is required for the activation of ICE...
- Isolation and characterization of a human dual specificity protein-tyrosine phosphatase geneS P Kwak
Department of Biological Chemistry, University of Michigan, Ann Arbor 48109 0606
J Biol Chem 269:3596-604. 1994..The potential significance of a second cdc25 homology domain of CL100 is discussed...
- Transcriptional regulation of the cyclooxygenase-2 gene in macrophages by PU.1Myungsoo Joo
Department of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2650, USA
J Biol Chem 279:6658-65. 2004..We speculate that a combinatorial role of PU.1 and C/EBP-beta mediates the robust production of COX-2 products by macrophages which occurs in Gram-negative bacterial sepsis...
- An unusual member of the Cdk family: Cdk5Fatema A Dhariwala
Department of Life Sciences, Sophia College, B Desai Road, Mumbai 400026, India
Cell Mol Neurobiol 28:351-69. 2008..This review focuses on the role of Cdk5 in neural cells as regulator of cytoskeletal elements, axonal guidance, membrane transport, synaptogenesis and cell survival in normal and pathological conditions...
- Molecular and biochemical characterization of two P450 enzymes in the ecdysteroidogenic pathway of Drosophila melanogasterJames T Warren
Department of Biology, University of North Carolina, Chapel Hill, NC 27599 3280, USA
Proc Natl Acad Sci U S A 99:11043-8. 2002..Expression of dib and sad continues to be localized in this endocrine compartment during larval development, being maximal in both the late second and third instar larvae, about the time of the premolt peaks in the ecdysteroid titer...
- MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesisChung Fai Wong
CSIRO Livestock Industries, Queensland Bioscience Precinct, 306 Carmody Road, St Lucia 4067, QLD, Australia
J Biol Chem 283:9836-43. 2008..These results reveal a model of regulation during myogenesis whereby the up-regulation of miR-26a acts to post-transcriptionally repress Ezh2, a known suppressor of skeletal muscle cell differentiation...
- Tumor uptake and elimination of 2',2'-difluoro-2'-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: correlation with in vivo tumor responseA W Blackstock
Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27156, USA
Clin Cancer Res 7:3263-8. 2001..To test this hypothesis, we examined dFdCyd/dFdCTP uptake and clearance in HT-29 human colon carcinoma xenografts in nude mice by high-performance liquid chromatography (HPLC) and fluorine-19 magnetic resonance spectroscopy (F-19 MRS)...
- Identification of promoter elements responsible for transcriptional inhibition of polo-like kinase 1 and topoisomerase IIalpha genes by p21(WAF1/CIP1/SDI1)Hongming Zhu
Department of Molecular Genetics, University of Illinois at Chicago, 60607 7170, USA
Cell Cycle 1:59-66. 2002..These results indicate that inhibition of cell division-associated genes by p21 is mediated by different but overlapping mechanisms, which are not a general con-sequence of cell cycle arrest...
- Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cellsS D Desai
Department of Pharmacology, UMDNJ-Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
Cancer Res 61:5926-32. 2001....
- Control of Vascular Smooth Muscle Function by InsulinLouis Ragolia; Fiscal Year: 2006..abstract_text> ..
- Novel Proapoptotic BH3-only Proteins in Cancer ApoptosisChien An Hu; Fiscal Year: 2009..Deciphering functions of the novel BH3-only proteins and their interacting molecules should enhance our understanding, and potential utilization, of BH3-only proteins and lipid-mediated apoptosis in treatment of cancer. ..
- Symposium on Selenium in Biology and MedicineROGER SUNDE; Fiscal Year: 2006..The breath and depth of this meeting and its participants will help to better integrate this information, leading to additional advances and enhanced understanding of human health. [unreadable] [unreadable]..
- Development of molecular biology-based assays for human selenium statusROGER SUNDE; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Sir2 regulation and chemical modulationAnthony A Sauve; Fiscal Year: 2010..abstract_text> ..
- TCDD Impairs Prostate Development: Cyp2c39 & RetinoidsCHAD VEZINA; Fiscal Year: 2008..abstract_text> ..
- Role of Lamin B Receptor in Neutrophil Maturation and Functional ActivationPeter Gaines; Fiscal Year: 2007..The results may also offer important insight into the pathogenesis of potentially fatal hematologic disorders. [unreadable] [unreadable] [unreadable]..
- Hypothalamic fMRI response to nutrientsJonathan Purnell; Fiscal Year: 2007..These studies will help us to better understand why changes in the diet might lead to weight gain or loss. [unreadable] [unreadable] [unreadable]..
- DIETARY MODULATION OF CELLULAR OXIDATIVE STRESS IN AGINGRAJINDAR SOHAL; Fiscal Year: 2007..Thus, it will also provide a further critical test of the validity of oxidative stress hypothesis of aging. ..
- Ethanol Effects on Human Astroglial Chemokine ExpressionRandall Davis; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- ESTROGEN BIOSYNTHESIS AND UTERINE LEIOMYOMATASerdar Bulun; Fiscal Year: 2007..We predict that these studies will establish the critical role of P450arom in uterine leiomyomata and lead to identification of novel therapeutic targets. ..
- Roles of PTP 1B Overexpression in Pathogenesis in vivoJANICE ZABOLOTNY; Fiscal Year: 2006..unreadable] [unreadable]..
- Immune Reactants, Cholesterol and AtherosclerosisALLISON REISS; Fiscal Year: 2006..abstract_text> ..
- Tissue engineering of small diameter vascular graftChangyi Chen; Fiscal Year: 2006..Success of this proposal will directly indicate the clinical applications of tissue engineered small diameter vascular grafts. ..
- Roles of PTP1B in Insulin and Leptin Action in vivoJANICE ZABOLOTNY; Fiscal Year: 2006..Kahn, an expert in characterizing animal models of obesity and diabetes, and Dr. Elmquist, an expert in mapping leptin-responsive pathways in the CNS, will provide an exemplary environment for my research. ..
- Estrogen, androgen, neprilysin, and amyloid peptides.Louis Hersh; Fiscal Year: 2008..unreadable] [unreadable]..
- CHARACTERIZATION OF A MAJOR OBESITY LOCUSCharles Farber; Fiscal Year: 2008..Lastly, aim 3 uses a genetical genomics approach to map eQTL for genes within the congenic interval. Data from these aims will enhance our understanding of the genetics and physiology of obesity. ..
- 2008 NOX Family NADPH Oxidases Gordon ConferenceWILLIAM NAUSEEF; Fiscal Year: 2008..End of Abstract) [unreadable] [unreadable] [unreadable]..
- PHARMACOGENETICS OF DRUG AND CARCINOGEN METABOLISMDavid Hein; Fiscal Year: 2009..We also will assess the effect of NAT1 and NAT2 genotypes in breast cancer risk through participation in ongoing molecular epidemiology investigations of breast cancer in Shanghai China and in Nashville, Tennessee. ..
- Metabolomics of the Virus-host Cell InteractionJoshua D Rabinowitz; Fiscal Year: 2010..Such pathways, once identified, will be attractive new targets for antiviral therapy. ..
- CITED2 and Mechanical LoadsHui Bin Sun; Fiscal Year: 2010....
- HOXB4 Is An Activator of HSC Self-RenewalGuy Sauvageau; Fiscal Year: 2009..This aim combines cell purification of newly characterized HSC populations with microarray analysis from small cell numbers and preliminary target gene validation. ..
- Fibronectin Fragment-Induced Osteolysis Mediated by MMPsSunil Kapila; Fiscal Year: 2009..These studies will provide a fundamental understanding of the basis for bone loss in periodontal disease and other osteolytic diseases. ..
- SIGNAL TRANSDUCTION MECHANISMS IN BACTERIAL CHEMOTAXISRichard Stewart; Fiscal Year: 2009..Our results will help to define general concepts about regulation and clustering of receptor-kinase complexes. ..
- FAMILIAL COLORECTAL NEOPLASIA COLLABORATIVE GROUPNoralane Lindor; Fiscal Year: 2007..fs20\par \par } ..
- Estrogen regulation of uterine microRNAs: Novel factors in MMP-9 regulationWarren Nothnick; Fiscal Year: 2008..Enhancing our understanding on the regulation of MMP-9 expression may lead to the establishment of novel approaches to counteract mis-expression of this protease and the diseases associated with it. [unreadable] [unreadable] [unreadable]..
- Structure and Regulation of Ghrelin in ObesityJonathan Q Purnell; Fiscal Year: 2010..Results from these studies will broaden our understanding of the brain-gut axis involved in body weight regulation by clarifying the regulation of ghrelin levels and structure in lean and obese individuals. ..
- CRANIOFACIAL SKELETAL TISSUE ENGINEERING CONFERENCESunil Kapila; Fiscal Year: 2008..The meeting will be limited to 250 participants who have a background in bioengineering. ..
- Iron Therapy in Renal Disease: Potential ToxicitiesRICHARD ZAGER; Fiscal Year: 2008..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..
- MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSISSerdar Bulun; Fiscal Year: 2008..Investigation of local feedback mechanisms responsible for interactions between estrogen biosynthesis, tissue growth, and inflammation will lead to the rational design of novel drug treatments. ..
- Stretch Mediated Myoblast Proliferation and/or SurvivalJEFFREY OTIS; Fiscal Year: 2006..Understanding the molecular mechanisms that regulate muscle growth is important for developing effective pharmacologic or genetic therapies to combat the number of clinical conditions associated with muscle atrophy. ..
- Genetic Analysis of Vascular AgingSteven Miller; Fiscal Year: 2003..abstract_text> ..
- Androgenic And Antiandorgenic Interactions Of PC-SPESCHARLES ROSELLI; Fiscal Year: 2002..Specific Aim 3: To evaluate the effect of PCSPES on Cytochrome P450-mediated metabolism of androgenic and antiandrogenic drugs by the liver, in order to identify possible interactions of PC-SPES with other hormone therapies. ..
- LEUKEMIA THERAPY WITH MIHA SPECIFIC T CELLSWei Chen; Fiscal Year: 2002..3. To develop methods develops for in vitro induction of MiHA-specific T cells for leukemia therapy. ..
- Sex steroid, HPA regulation, and fat patterningJonathan Purnell; Fiscal Year: 2003..abstract_text> ..
- HIV/SIV ENVELOPE GLYCOPROTEIN EFFECTS ON ENDOTHELIAChangyi Chen; Fiscal Year: 2002....
- Enzymes of Skin Lipid MetabolismDavid Russell; Fiscal Year: 2009..The research is relevant to skin disease, dry eye syndrome, and cholesterol metabolism. ..
- PATHOGENEISIS OF CYSTIC FIBROSIS IN THE GI SYSTEMROBERT DE LISLE; Fiscal Year: 2003..Pathology and Muclin expression will be compared in CF mice, and CF mice crossed with gastrin deficient mice (lack gastric acid secretion) to normalize intestinal Ph. ..
- REGULATION OF FLAVIN MONOOXYGENASE GENE EXPRESSIONRONALD HINES; Fiscal Year: 2003..It will be critical for the future rationale design of drugs and therapeutic regimens, as well as for the development of prevention/intervention strategies for at risk individuals or populations. ..
- HOW DOES ALCHOHOL SUPPRESS GLIAL NOS-2 GENE EXPRESSIONPETER SYAPIN; Fiscal Year: 2003..The results will have broad implications for understanding ethanol effects on CNS gene expression, which is proposed to underlie chronic behavioral and pathophysiologic effects of alcohol. ..
- ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICSRICHARD ZAGER; Fiscal Year: 2001....
- Effects of HIV Protease Inhibitors of Endothelial BarrieChangyi Chen; Fiscal Year: 2005..Our findings may also suggest new therapeutic strategies, which may eventually prove effective for the prevention and treatment of these complications. ..
- Anti-Inflammatory PAF Acetylhydrolase in Lung InjuryKatherine Howard; Fiscal Year: 2004..Through the logical design of the proposed studies, novel and important information will be gained that will significantly advance our understanding of the cell biology of this important anti-inflammatory enzyme. ..
- Craniofacial Imaging in the 21st CenturySunil Kapila; Fiscal Year: 2002..The meeting will be limited to 300 participants who have a background in imaging. This symposia series will provide momentum to discoveries that will be important to craniofacial sciences and patient care. ..
- CHOLINE ACETYLTRANSFERASELouis Hersh; Fiscal Year: 2004....
- MR STUDIES OF EXPERIMENTAL RETINOPATHY OF PREMATURITYBRUCE BERKOWITZ; Fiscal Year: 2001..This work may have broad impact beyond ROP since abnormal blood vessel growth is a common pathobiologic event for other blinding disorders, such as diabetic retinopathy. ..
- CYP1A1 GENE AND ENVIRONMENTAL TOXICITYDaniel Nebert; Fiscal Year: 2005..abstract_text> ..
- MECHANISMS OF TOXICITY GORDON CONFERENCERONALD HINES; Fiscal Year: 2002..There also is substantial involvement of new personnel as Chairs and co-Chairs. Thus, the Mechanism of Toxicity GRC is poised to continue its growth as the single leading small conference on Molecular Toxicology. ..
- Epidermal Mechanisms Opposing Ceramide-Induced ApoptosisYoshikazu Uchida; Fiscal Year: 2009....
- ANGIOTENSIN II AND REGULATION OF MCP-1 GENE EXPRESSIONChangyi Chen; Fiscal Year: 2002....
- Tumor Necrosis Factor-Alpha Signaling in Breast CancerAlakananda Basu; Fiscal Year: 2009..The long-term objective is to develop strategies to intervene with these pathways to inhibit progression of breast cancer. ..
- LETHAL MUTAGENESIS OF HIV BY DEOXYNUCLEOSIDE ANALOGSLAWRENCE LOEB; Fiscal Year: 2002....
- Molecular Surgeon Symposium on Genetics and Genomics of Pancreatic CancerChangyi Chen; Fiscal Year: 2008..Furthermore, invited speakers are encouraged to submit manuscripts related to their presentations to "World Journal of Surgery" for consideration of publications. [unreadable] [unreadable] [unreadable]..
- Role of the 5-Lipoxygenase Pathway in AtherosclerosisHooman Allayee; Fiscal Year: 2009....
- Novel Roles for MMP-8 in Acute Lung InjuryCaroline Owen; Fiscal Year: 2008..We anticipate that in the future, our studies will facilitate the development of new treatment strategies that may reduce mortality and morbidity in ALl syndromes. ..
- COENZYME Q INTAKE, OXIDATIVE STRESS, AND AGING IN MICERAJINDAR SOHAL; Fiscal Year: 2004..Results of this study will provide an understanding of the mechanisms by which CoQ intake may have a beneficial or deleterious effect on the aging process in mice. ..
- ESTROGEN BIOTRANSFORMATIONS AND BREAST CANCER ETIOLOGYROBERT BRUEGGEMEIER; Fiscal Year: 2006..3) To measure cellular levels of aromatase expression and cyclooxygenases expression in human breast cancer specimens. ..
- Migraine Headache Treatment by Drug Aerosol InhalationJoshua Rabinowitz; Fiscal Year: 2004..Accomplishment of the goals of Phase II will lead directly to human clinical testing of a commercially viable device that could improve the lives of millions of people every year. ..
- Attenuation of astroglial chemokine expression by beta-funaltrexamine: implicatioRandall Davis; Fiscal Year: 2008..This training will lend to the success of these students in their future careers in health related professions. [unreadable] [unreadable] [unreadable]..
- RENAL INJURY AND ADAPTATION TO HEME PROTEINSKarl Nath; Fiscal Year: 2001..Our proposed application thus continues to pursue the functionality of HO-1, as it utilized a new strategy, transgenic mice, and as it defines a new area of involvement namely, renal inflammation. ..
- FACILITIES CONSTRUCTION CENTERALIZED PHARMCOGENOMICSPalmer Taylor; Fiscal Year: 2003..The Centralized Animal Facility is critically needed to support this effort and allow economies of scale for animal research. ..
- Nicotinic Receptor Template-guided Drug DesignPalmer Taylor; Fiscal Year: 2008..The final stages of investigation will include studies in rodents to determine efficacy and toxicity. ..
- Curcumin-based analogs as improved inhibitors of Abeta aggregationROBERT ORLANDO; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- KINETICS OF DRUG MACROMOLECULE COMPLEX FORMATIONPalmer Taylor; Fiscal Year: 2008..abstract_text> ..
- MOLECULAR REGULATION OF THE HUMAN BRCA 1 GENEDONATO ROMAGNOLO; Fiscal Year: 2003..Specific aim #3 will examine the function of BRCA-1 in cell cycle regulation at different levels of genotoxic damage induced by PAHs. ..
- CELL SURFACE ACTIVITIES IN LIPOPROTEIN CATABOLISMROBERT ORLANDO; Fiscal Year: 2003....
- VIRULENCE, OXYGEN AND PROTEIN F IN STEPTOCOCCUS PYOGENESMichael Caparon; Fiscal Year: 2004..Since most of these genes are unique, a number of promising candidate drug targets may be identified. ..
- ANTIMITOGENIC MECHANISMS OF PKG IN VASCULAR SM CELLSJESSE ROBERTS; Fiscal Year: 2004..In addition, a carefully constructed training program has been developed that will permit successful development of an independent research career examining the basic mechanisms of pulmonary vascular diseases. ..
- Repair of DNA breaks in humans: the role of Rad54 proteinAlexander Mazin; Fiscal Year: 2008..Here we will characterize these interactions and their effect on the enzymatic activities of both hRad54 and Mus81/Eme1 (Aim 4). ..
- IN VIVO GENE EXPRESSION IN STAPHYLOCCUS AUREUSAmbrose Cheung; Fiscal Year: 2009..Upon the completion of these studies, we hope to understand how sae is activated in vivo and what target genes sae impacts during infection. ..
- Binding and regulation mechanism for S aureusAmbrose Cheung; Fiscal Year: 2006..An understanding of these mechanisms will facilitate the development of novel agents that interfere with the function of the SarA family and the ensuing synthesis of cell wall adhesins and toxins. ..
- H.pylori Effects on DNA Repair in Gastric EpitheliumAntonia Sepulveda; Fiscal Year: 2008..Knowledge gained from this study is likely to support the indication for Hp eradication in H. pylori-infected patients to prevent GC. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- A Screen for Modulators of Human Rad51, a Key DNA Repair ProteinAlexander Mazin; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Central ACE2, Blood Pressure Regulation and HypertensionEric Lazartigues; Fiscal Year: 2008..Evidence of a role of ACE2 in the regulation of BP could lead to the development of new therapeutics as well as a better utilization of existing therapeutics for the treatment of hypertension and other CV diseases. ..
- PAHs: Balance of Detoxication vs Metabolic ActivationDaniel Nebert; Fiscal Year: 2009..dissemination of ingested BaP and will be informative in clinical studies in which we would determine which haplotypes of these three human genes might be associated with resistance vs. sensitivity to PAH-induced toxicity and cancer. ..
- REGULATION OF CELL MIGRATION IN VASCULAR REMODELINGEric Howard; Fiscal Year: 2002..Understanding this mechanism will be important in defining the biochemical events that occur during vascular remodeling in both normal and disease processes. ..
- Cellular Immune Response of Mosquitoes to PathogensJULIAN HILLYER; Fiscal Year: 2003..In understanding the immune response mounted by different insect species and strains toward pathogens, it may be possible to manipulate existing vectors to make the parasite/vector biologic interplay incompatible. ..