fungal chromosomes

Summary

Summary: Structures within the nucleus of fungal cells consisting of or containing DNA, which carry genetic information essential to the cell.

Top Publications

  1. ncbi The genome sequence of Schizosaccharomyces pombe
    V Wood
    The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nature 415:871-80. 2002
  2. ncbi The single-end invasion: an asymmetric intermediate at the double-strand break to double-holliday junction transition of meiotic recombination
    N Hunter
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Cell 106:59-70. 2001
  3. ncbi Dissecting the architecture of a quantitative trait locus in yeast
    Lars M Steinmetz
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 416:326-30. 2002
  4. ncbi Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins
    R Ciosk
    Research Institute of Molecular Pathology, Vienna, Austria
    Mol Cell 5:243-54. 2000
  5. pmc Aneuploidy and isochromosome formation in drug-resistant Candida albicans
    Anna Selmecki
    Department of Genetics, Cell Biology, and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Science 313:367-70. 2006
  6. pmc Identification of cis-acting sites for condensin loading onto budding yeast chromosomes
    Claudio D'Ambrosio
    Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, London, UK
    Genes Dev 22:2215-27. 2008
  7. pmc Long-range compaction and flexibility of interphase chromatin in budding yeast analyzed by high-resolution imaging techniques
    Kerstin Bystricky
    Department of Molecular Biology and National Center of Competence in Research Frontiers in Genetics, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva, Switzerland
    Proc Natl Acad Sci U S A 101:16495-500. 2004
  8. pmc A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae
    V Guacci
    Howard Hughes Medical Institute, Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Cell 91:47-57. 1997
  9. ncbi Template switching during break-induced replication
    Catherine E Smith
    Department of Microbiology, Columbia University Medical Center, 701 West 168th Street, New York, New York 10032, USA
    Nature 447:102-5. 2007
  10. ncbi Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes
    Yuji Chikashige
    Cell Biology Group and CREST Research Project, Kansai Advanced Research Center, National Institute of Information and Communications Technology, 588 2 Iwaoka, Iwaoka cho, Nishi ku, Kobe 651 2492, Japan
    Cell 125:59-69. 2006

Detail Information

Publications256 found, 100 shown here

  1. ncbi The genome sequence of Schizosaccharomyces pombe
    V Wood
    The Wellcome Trust Sanger Institute, The Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nature 415:871-80. 2002
    ....
  2. ncbi The single-end invasion: an asymmetric intermediate at the double-strand break to double-holliday junction transition of meiotic recombination
    N Hunter
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA
    Cell 106:59-70. 2001
    ..This feature can explain crossover suppression between homeologous and structurally heterozygous chromosomes...
  3. ncbi Dissecting the architecture of a quantitative trait locus in yeast
    Lars M Steinmetz
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA
    Nature 416:326-30. 2002
    ..It also demonstrates a deficiency in current approaches to QTL dissection with implications extending to traits in other organisms, including human genetic diseases...
  4. ncbi Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins
    R Ciosk
    Research Institute of Molecular Pathology, Vienna, Austria
    Mol Cell 5:243-54. 2000
    ..Our data suggest that a major role for the Scc2p/Scc4p complex is to facilitate the loading of cohesin complexes onto chromosomes...
  5. pmc Aneuploidy and isochromosome formation in drug-resistant Candida albicans
    Anna Selmecki
    Department of Genetics, Cell Biology, and Development, University of Minnesota, 6 160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Science 313:367-70. 2006
    ....
  6. pmc Identification of cis-acting sites for condensin loading onto budding yeast chromosomes
    Claudio D'Ambrosio
    Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, London, UK
    Genes Dev 22:2215-27. 2008
    ..This reveals that TFIIIC-binding sites, including tRNA genes, constitute a hitherto unknown chromosomal feature with important implications for chromosome architecture during both interphase and mitosis...
  7. pmc Long-range compaction and flexibility of interphase chromatin in budding yeast analyzed by high-resolution imaging techniques
    Kerstin Bystricky
    Department of Molecular Biology and National Center of Competence in Research Frontiers in Genetics, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva, Switzerland
    Proc Natl Acad Sci U S A 101:16495-500. 2004
    ....
  8. pmc A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae
    V Guacci
    Howard Hughes Medical Institute, Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Cell 91:47-57. 1997
    ..These data implicate Mcd1p as a nexus between cohesion and condensation. We present a model for mitotic chromosome structure that incorporates this previously unsuspected link...
  9. ncbi Template switching during break-induced replication
    Catherine E Smith
    Department of Microbiology, Columbia University Medical Center, 701 West 168th Street, New York, New York 10032, USA
    Nature 447:102-5. 2007
    ..This dynamic process could function to promote gene conversion by capture of the displaced invading strand at two-ended DSBs to prevent BIR...
  10. ncbi Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes
    Yuji Chikashige
    Cell Biology Group and CREST Research Project, Kansai Advanced Research Center, National Institute of Information and Communications Technology, 588 2 Iwaoka, Iwaoka cho, Nishi ku, Kobe 651 2492, Japan
    Cell 125:59-69. 2006
    ..Significantly, when both Bqt1 and Bqt2 are ectopically expressed in mitotic cells, they also form a bridge between Rap1 and Sad1. Thus, a complex including Bqt1 and Bqt2 is essential for connecting telomeres to the SPB...
  11. pmc High-resolution mapping of meiotic crossovers and non-crossovers in yeast
    Eugenio Mancera
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nature 454:479-85. 2008
    ..In addition, because non-crossover hotspots create holes of reduced linkage within haplotype blocks, our results stress the need to incorporate non-crossovers into genetic linkage analysis...
  12. pmc NDT80, a meiosis-specific gene required for exit from pachytene in Saccharomyces cerevisiae
    L Xu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Mol Cell Biol 15:6572-81. 1995
    ....
  13. ncbi Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin
    S B Buonomo
    Research Institute of Molecular Pathology, University of Vienna, Austria
    Cell 103:387-98. 2000
    ..We show here that cleavage of Rec8 by separin at one of two different sites is necessary for the resolution of chiasmata and the disjunction of homologous chromosomes during meiosis...
  14. pmc Global analysis of the meiotic crossover landscape
    Stacy Y Chen
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA
    Dev Cell 15:401-15. 2008
    ..Lastly, we uncover a surprising role for the synaptonemal complex component Zip1 in repressing crossing over at the centromere...
  15. ncbi Zip3 provides a link between recombination enzymes and synaptonemal complex proteins
    S Agarwal
    Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Cell 102:245-55. 2000
    ..We speculate that Zip3 is a component of recombination nodules and serves to link the initiation of synapsis to meiotic recombination...
  16. pmc Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56
    Robert Driscoll
    Wellcome Trust and Cancer Research U K Gurdon Institute and the Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    Science 315:649-52. 2007
    ..These data establish Rtt109p as a member of a new class of histone acetyltransferases and show that its actions are critical for cell survival in the presence of DNA damage during S phase...
  17. ncbi Cohesins bind to preferential sites along yeast chromosome III, with differential regulation along arms versus the centric region
    Y Blat
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Cell 98:249-59. 1999
    ..The methodology described can be used to analyze the distribution of any DNA-binding protein and, via microchips, along entire genomes...
  18. ncbi Crossover assurance and crossover interference are distinctly regulated by the ZMM proteins during yeast meiosis
    Miki Shinohara
    Institute for Protein Research, Osaka University, Suita 565 0871, Japan
    Nat Genet 40:299-309. 2008
    ..In contrast, crossover assurance requires all ZMM proteins and full-length synaptonemal complexes...
  19. ncbi An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast
    R Ciosk
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 93:1067-76. 1998
    ..We propose that the APC promotes sister separation not by destroying cohesins but instead by liberating the "sister-separating" Esp1 protein from its inhibitor Pds1p...
  20. ncbi Genome evolution in yeasts
    Bernard Dujon
    Unité de Génétique Moléculaire des Levures, URA 2171 CNRS and UFR 927 Université Pierre et Marie Curie
    Nature 430:35-44. 2004
    ....
  21. ncbi Budding yeast Wpl1(Rad61)-Pds5 complex counteracts sister chromatid cohesion-establishing reaction
    Takashi Sutani
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsuta cho, Midori ku, Yokohama, Kanagawa 226 8501, Japan
    Curr Biol 19:492-7. 2009
    ..Taken together, the presented data suggest that Wpl1-Pds5 complex is inhibitory for cohesion establishment and that Eco1 establishes cohesion by hindering the function of Wpl1-Pds5 temporally in S phase...
  22. pmc Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae
    S Biggins
    Department of Physiology, University of California, San Francisco, 94143, USA
    Genetics 159:453-70. 2001
    ..We also report an initial characterization of phenotypes associated with the SMT3/SUMO gene and the isolation of WSS1, a high-copy smt3 suppressor...
  23. ncbi ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones
    Rita S Cha
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 297:602-6. 2002
    ..Thus, Mec1 has important functions in normal S phase and the genome instability of mec1 (and, analogously, ATR-/-) mutants stems from defects in these basic roles...
  24. ncbi Role of Polo-like kinase CDC5 in programming meiosis I chromosome segregation
    Brian H Lee
    Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17 233, 40 Ames Street, Cambridge, MA 02139, USA
    Science 300:482-6. 2003
    ..Thus, sister-kinetochore coorientation and chromosome segregation during meiosis I are coupled through their dependence on CDC5...
  25. ncbi Molecular evidence for an ancient duplication of the entire yeast genome
    K H Wolfe
    Department of Genetics, University of Dublin, Trinity College, Ireland
    Nature 387:708-13. 1997
    ..Tetraploidy may have facilitated the evolution of anaerobic fermentation in Saccharomyces...
  26. ncbi Chromosomal association of the Smc5/6 complex reveals that it functions in differently regulated pathways
    Hanna Betts Lindroos
    Department of Cell and Molecular Biology, Karolinska Institute, 171 77 Stockholm, Sweden
    Mol Cell 22:755-67. 2006
    ..Altogether this shows that the complex maintains genomic integrity in multiple ways, and evidence is presented that the Smc5/6 complex is needed during replication to prevent the accumulation of branched chromosome structures...
  27. ncbi Identification of cohesin association sites at centromeres and along chromosome arms
    T Tanaka
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 98:847-58. 1999
    ..Finally, cohesion associated with "minimal" centromeres is insufficient to resist the splitting force exerted by microtubules and appears to be reinforced by cohesion provided by their flanking DNA sequences...
  28. ncbi A genome-wide screen identifies genes required for centromeric cohesion
    Adele L Marston
    Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17 233, 40 Ames Street, Cambridge, MA 02139, USA
    Science 303:1367-70. 2004
    ..The screen described here provides a comprehensive analysis of the genes required for the meiotic cell cycle and identifies three factors important for the stepwise loss of sister chromatid cohesion...
  29. ncbi The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes
    Vahan B Indjeian
    Department of Molecular and Cellular Biology, Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Science 307:130-3. 2005
    ....
  30. pmc A barrier nucleosome model for statistical positioning of nucleosomes throughout the yeast genome
    Travis N Mavrich
    Center for Gene Regulation, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genome Res 18:1073-83. 2008
    ..3' NFRs may be important for transcription termination and anti-sense initiation. We present a high-resolution genome-wide map of TFIIB locations that implicates 3' NFRs in gene looping...
  31. ncbi A synaptonemal complex protein promotes homology-independent centromere coupling
    Tomomi Tsubouchi
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Science 308:870-3. 2005
    ..Regions of synaptonemal complex assembled early in meiosis are often centromere-associated. We propose that centromere coupling facilitates homolog pairing and promotes synapsis initiation...
  32. pmc The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans
    Brendan J Loftus
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 307:1321-4. 2005
    ..neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes...
  33. ncbi Budding yeast mitotic chromosomes have an intrinsic bias to biorient on the spindle
    Vahan B Indjeian
    Department of Molecular and Cellular Biology, Harvard University, Massachusetts 02138, USA
    Curr Biol 17:1837-46. 2007
    ..After the spindle has been depolymerized and allowed to reform, budding yeast sgo1 mutants fail to biorient their sister chromatids and die as cells divide...
  34. ncbi Roles for two RecA homologs in promoting meiotic chromosome synapsis
    B Rockmill
    Department of Biology, Yale University, New Haven, Connecticut 06520 8103, USA
    Genes Dev 9:2684-95. 1995
    ..In a zip1 haploid, axial associations are not apparent, suggesting that these associations depend on interactions between homologous sequences...
  35. pmc Initiation of meiotic chromosome synapsis at centromeres in budding yeast
    Tomomi Tsubouchi
    Howard Hughes Medical Institute, Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    Genes Dev 22:3217-26. 2008
    ..Our data provide evidence for two classes of synapsis initiation events that differ in location, timing, genetic requirements, and relationship to meiotic recombination...
  36. ncbi Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination
    Michael N Conrad
    Program in Molecular, Cell and Developmental Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Cell 133:1175-87. 2008
    ..Together with recombination defects described for ndj1, our observations suggest that RPMs and SCs balance the disruption and stabilization of recombinational interactions, respectively, to regulate crossing over...
  37. ncbi RecA homologs Dmc1 and Rad51 interact to form multiple nuclear complexes prior to meiotic chromosome synapsis
    D K Bishop
    Department of Radiation and Cellular Oncology, University of Chicago, Illinois 60638
    Cell 79:1081-92. 1994
    ..Analysis of zip1 mutants shows that Zip1 promotes dissociation of Dmc1 complexes. Colocalization of Dmc1 and Zip1 raises the possibility that Dmc1 and Rad51 are components of recombination nodules...
  38. pmc Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans
    D W Brown
    Department of Plant Pathology, Texas A and M University, College Station 77843, USA
    Proc Natl Acad Sci U S A 93:1418-22. 1996
    ..A revised system for naming the genes of the ST pathway is presented...
  39. pmc Chromosome mobility during meiotic prophase in Saccharomyces cerevisiae
    Harry Scherthan
    Max Planck Institute for Molecular Genetics, D 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 104:16934-9. 2007
    ..These results show that SC movements involve telomere attachment to the nuclear periphery and are actin-dependent and suggest these movements could facilitate completion of meiotic recombination...
  40. ncbi Effects of aneuploidy on cellular physiology and cell division in haploid yeast
    Eduardo M Torres
    Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17 233, 40 Ames Street, Cambridge, MA 02139, USA
    Science 317:916-24. 2007
    ..We conclude that aneuploidy causes not only a proliferative disadvantage but also a set of phenotypes that is independent of the identity of the individual extra chromosomes...
  41. pmc Meiotic chromosomes move by linkage to dynamic actin cables with transduction of force through the nuclear envelope
    R Koszul
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Cell 133:1188-201. 2008
    ..Mechanical properties of the system and biological roles of mid-prophase movement for meiosis, including recombination, are discussed...
  42. ncbi The delitto perfetto approach to in vivo site-directed mutagenesis and chromosome rearrangements with synthetic oligonucleotides in yeast
    Francesca Storici
    Laboratory of Molecular Genetics, Chromosome Stability Section, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Methods Enzymol 409:329-45. 2006
    ....
  43. ncbi Replication dynamics of the yeast genome
    M K Raghuraman
    Department of Genetics, Department of Mathematics, University of Washington, Seattle, WA 98195, USA
    Science 294:115-21. 2001
    ..The two ends of each of the 16 chromosomes are highly correlated in their times of replication. This microarray approach is readily applicable to other organisms, including humans...
  44. ncbi Zip2, a meiosis-specific protein required for the initiation of chromosome synapsis
    P R Chua
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520 8103, USA
    Cell 93:349-59. 1998
    ..We propose that Zip2p promotes the initiation of chromosome synapsis and that localization of Zip2p to sites of interhomolog recombination ensures synapsis between homologous chromosomes...
  45. ncbi SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family
    A V Strunnikov
    Carnegie Institution of Washington, Department of Embryology, Baltimore, Maryland 21210
    Genes Dev 9:587-99. 1995
    ....
  46. ncbi SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase
    Boris Pfander
    Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany
    Nature 436:428-33. 2005
    ..Our finding suggests a model in which SUMO-modified PCNA recruits Srs2 in S phase in order to prevent unwanted recombination events of replicating chromosomes...
  47. pmc Csm4, in collaboration with Ndj1, mediates telomere-led chromosome dynamics and recombination during yeast meiosis
    Jennifer J Wanat
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA
    PLoS Genet 4:e1000188. 2008
    ....
  48. pmc Saccharomyces cerevisiae checkpoint genes MEC1, RAD17 and RAD24 are required for normal meiotic recombination partner choice
    J M Grushcow
    Department of Radiation, University of Chicago, Chicago, Illinois 60637, USA
    Genetics 153:607-20. 1999
    ..These observations support the suggestion that MEC1, RAD17, and RAD24, in addition to their proposed monitoring function, act to promote normal meiotic recombination...
  49. pmc Chromosomal addresses of the cohesin component Mcd1p
    S Laloraya
    Howard Hughes Medical Institute, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    J Cell Biol 151:1047-56. 2000
    ..Thus, the periodicity of CARs in single-copy regions and the rDNA repeats is conserved. The presence and spacing of CARs in repetitive DNA has important implications for genomic stability and chromosome packaging/condensation...
  50. ncbi The cohesin ring concatenates sister DNA molecules
    Christian H Haering
    University of Oxford, Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK
    Nature 454:297-301. 2008
    ..As predicted by the ring entrapment model, this procedure produced dimeric DNA-cohesin structures that are resistant to protein denaturation. We conclude that cohesin rings concatenate individual sister minichromosome DNA molecules...
  51. pmc Centromeric DNA sequences in the pathogenic yeast Candida albicans are all different and unique
    Kaustuv Sanyal
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 101:11374-9. 2004
    ..albicans contains a different and unique CaCse4p-rich centromeric DNA sequence, a centromeric property previously unobserved in other organisms...
  52. pmc The core centromere and Sgo1 establish a 50-kb cohesin-protected domain around centromeres during meiosis I
    Brendan M Kiburz
    Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Genes Dev 19:3017-30. 2005
    ..Our results identify the portions of chromosomes where cohesins are protected from removal during meiosis I and show that kinetochore components and cohesins themselves are required to establish this cohesin protective domain...
  53. ncbi An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1
    Anna Selmecki
    Department of Genetics, Cell and Development, University of Minnesota, Minneapolis, MN 55305, USA
    Mol Microbiol 68:624-41. 2008
    ..Thus, the major mechanism by which i(5L) formation causes increased azole resistance is by amplifying two genes: ERG11 and TAC1...
  54. pmc Progression of meiotic DNA replication is modulated by interchromosomal interaction proteins, negatively by Spo11p and positively by Rec8p
    R S Cha
    Department of Molecular Biology, Harvard University, Cambridge, Massachusetts 02138 USA
    Genes Dev 14:493-503. 2000
    ..Roles for Rec8 and/or Spo11 in progression through other stages of meiosis are also revealed...
  55. ncbi Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast
    F Uhlmann
    Research Institute of Molecular Pathology, Vienna, Austria
    Cell 103:375-86. 2000
    ..Cleavage of Sccl in metaphase arrested cells is sufficient to trigger the separation of sister chromatids and their segregation to opposite cell poles...
  56. pmc The role of DNA double-strand breaks in spontaneous homologous recombination in S. cerevisiae
    Gaëlle Lettier
    Center for Microbial Biotechnology, BioCentrum DTU, Technical University of Denmark, Lyngby, Denmark
    PLoS Genet 2:e194. 2006
    ....
  57. pmc A Bir1-Sli15 complex connects centromeres to microtubules and is required to sense kinetochore tension
    Sharsti Sandall
    Ludwig Institute for Cancer Research Department of Cellular and Molecular Medicine, CMM E Room 3052, 9500 Gilman Drive, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 127:1179-91. 2006
    ....
  58. pmc Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe
    Ken ichi Nakamura
    Department of Biological Sciences, Graduate School of Science, Toyonaka, Osaka University, Osaka, Japan
    EMBO J 27:3036-46. 2008
    ..Chromatin immunoprecipitation analysis shows that Rad51 localizes at centromere around S phase. These data suggest that Rad51 suppresses rearrangements of centromere repeats that result in isochromosome formation...
  59. ncbi The HOP1 gene encodes a meiosis-specific component of yeast chromosomes
    N M Hollingsworth
    Department of Genetics, University of Washington, Seattle 98195
    Cell 61:73-84. 1990
    ..These observations demonstrate that HOP1 encodes a component of meiotic chromosomes, perhaps serving as a constituent of the synaptonemal complex...
  60. pmc Mapping meiotic single-strand DNA reveals a new landscape of DNA double-strand breaks in Saccharomyces cerevisiae
    Cyril Buhler
    Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Biol 5:e324. 2007
    ....
  61. ncbi Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
    Herman J Pel
    DSM Food Specialties, PO Box 1, 2600 MA Delft, The Netherlands
    Nat Biotechnol 25:221-31. 2007
    ..niger. Noteworthy is the large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors, and the presence of putative gene clusters for fumonisin and ochratoxin A synthesis...
  62. pmc Mrc1 and Tof1 regulate DNA replication forks in different ways during normal S phase
    Ben Hodgson
    Cancer Research U K, Paterson Institute for Cancer Research, University of Manchester, Manchester M20 4BX, United Kingdom
    Mol Biol Cell 18:3894-902. 2007
    ..In contrast, Tof1 is critical for DNA replication forks to pause at diverse chromosomal sites where nonnucleosomal proteins bind very tightly to DNA, and this role is not shared with Mrc1...
  63. pmc Zip1-induced changes in synaptonemal complex structure and polycomplex assembly
    M Sym
    Department of Biology, Yale University, New Haven, Connecticut 06520 8103
    J Cell Biol 128:455-66. 1995
    ..Our results demonstrate that Zip1 is a structural component of the central region of the SC. More specifically, we speculate that Zip1 is a component of the transverse filaments that lie perpendicular to the long axis of the complex...
  64. pmc Yeast Mre11 and Rad1 proteins define a Ku-independent mechanism to repair double-strand breaks lacking overlapping end sequences
    Jia Lin Ma
    Department of Molecular Medicine, Institute of Biotechnology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA
    Mol Cell Biol 23:8820-8. 2003
    ..The increased gamma ray sensitivity of rad1Delta rad52Delta yku70Delta strains compared to rad52Delta yku70Delta strains suggests that MMEJ also contributes to the repair of DSBs induced by ionizing radiation...
  65. pmc An extragenic suppressor of the mitosis-defective bimD6 mutation of Aspergillus nidulans codes for a chromosome scaffold protein
    C L Holt
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genetics 142:777-87. 1996
    ..SUDA belongs to the DA-box protein family. DA-box proteins have been shown to function in chromosome structure and segregation. Thus bimD and the sud genes cooperatively function in chromosome segregation in Aspergillus nidulans...
  66. pmc Ku complex controls the replication time of DNA in telomere regions
    Andrew J Cosgrove
    Cancer Research UK Chromosome Replication Research Group, Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland
    Genes Dev 16:2485-90. 2002
    ..Ku is one of the first components identified as important for replication timing, and specification of the replication time of chromosome ends by Ku is consistent with its role in maintaining telomere localization...
  67. pmc Gene conversion and crossing over along the 405-kb left arm of Saccharomyces cerevisiae chromosome VII
    Anna Malkova
    Department of Biology and Rosenstiel Center, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    Genetics 168:49-63. 2004
    ....
  68. pmc Saccharomyces cerevisiae CTF18 and CTF4 are required for sister chromatid cohesion
    J S Hanna
    McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Mol Cell Biol 21:3144-58. 2001
    ..The requirement for CTF4 and CTF18 in robust cohesion identifies novel roles for replication accessory proteins in this process...
  69. pmc Controlled exchange of chromosomal arms reveals principles driving telomere interactions in yeast
    Heiko Schober
    Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland
    Genome Res 18:261-71. 2008
    ..These results can be explained by the polarized Rabl arrangement of yeast centromeres and telomeres, which promote to telomere pairing by allowing contact between chromosome arms of equal length in anaphase...
  70. ncbi The transcriptional program of sporulation in budding yeast
    S Chu
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143 0448, USA
    Science 282:699-705. 1998
    ..The temporal expression pattern provided clues to potential functions of hundreds of previously uncharacterized genes, some of which have vertebrate homologs that may function during gametogenesis...
  71. pmc Aberrant double-strand break repair resulting in half crossovers in mutants defective for Rad51 or the DNA polymerase delta complex
    Catherine E Smith
    Columbia University College of Physicians and Surgeons, Department of Microbiology, New York, NY 10032 2704, USA
    Mol Cell Biol 29:1432-41. 2009
    ..Thus, the BIR defect observed for rad51 mutants is due to strand invasion failure, whereas the Pol delta complex mutants are proficient for strand invasion but unable to complete extensive tracts of recombination-initiated DNA synthesis...
  72. pmc Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast
    F Klein
    Swiss Institute for Experimental Cancer Research ISREC, Epalinges s Lausanne
    J Cell Biol 117:935-48. 1992
    ..Approximately 16 brightly staining foci can be identified in a diploid nucleus stained with anti-RAP1 antibodies, suggesting that telomeres are grouped together, perhaps through interaction with the nuclear envelope...
  73. ncbi The nucleotide sequence of Saccharomyces cerevisiae chromosome XII
    M Johnston
    The Genome Sequencing Center, Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 387:87-90. 1997
    ..All of the genes of this simple eukaryotic cell have recently been revealed by an international collaborative effort to determine the complete DNA sequence of its nuclear genome. Here we describe some of the features of chromosome XII...
  74. ncbi S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex
    Yuki Katou
    Genome Structure and Function Team, Human Genome Research Group, RIKEN Genomic Science Center, 1 7 22 Suehiro cho, Japan
    Nature 424:1078-83. 2003
    ..When hydroxyurea blocks chromosomal replication, this assembly forms a stable pausing structure that serves to anchor subsequent DNA repair events...
  75. pmc The multiple roles of cohesin in meiotic chromosome morphogenesis and pairing
    Gloria A Brar
    David H Koch Institute for Integrative Cancer Research and Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Mol Biol Cell 20:1030-47. 2009
    ..These findings define Rec8 as a key determinant of meiotic chromosome morphogenesis and a central player in multiple meiotic events...
  76. pmc Signaling through adenylyl cyclase is essential for hyphal growth and virulence in the pathogenic fungus Candida albicans
    C R Rocha
    Eukaryotic Genetics Group, Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec H4P 2R2, Canada
    Mol Biol Cell 12:3631-43. 2001
    ..These findings suggest that fungal adenylyl cyclases and other regulators of the cAMP signaling pathway may be useful targets for antifungal drugs...
  77. ncbi Two modes of survival of fission yeast without telomerase
    T M Nakamura
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309 0215, USA
    Science 282:493-6. 1998
    ..Moreover, the massive elongation of telomeres in taz1- cells is absent in the double mutant. Thus, Taz1p appears to regulate telomeric recombination as well as telomerase activity in fission yeast...
  78. pmc Rad18 is required for DNA repair and checkpoint responses in fission yeast
    H M Verkade
    Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, Melbourne, Victoria 8006, Australia
    Mol Biol Cell 10:2905-18. 1999
    ..These studies show a role for chromatin organization in the maintenance or activation of responses to DNA damage...
  79. pmc GC content and recombination: reassessing the causal effects for the Saccharomyces cerevisiae genome
    Marie Claude Marsolier-Kergoat
    Institut de Biologie et de Technologies de Saclay, Commissariat àl Energie Atomique Saclay, 91191 Gif sur Yvette, France
    Genetics 183:31-8. 2009
    ..These results pave the way for further analyses aimed at the detailed untangling of drives involved in the evolutionary shaping of the yeast genome...
  80. pmc Genetic and physical maps of Saccharomyces cerevisiae
    J M Cherry
    Department of Genetics, Stanford University School of Medicine, California 94305 5120, USA
    Nature 387:67-73. 1997
    ..The data for the maps are accessible electronically from the Saccharomyces Genome Database (SGD: http://genome-www.stanford. edu/Saccharomyces/)...
  81. ncbi Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map
    Sean R Collins
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA
    Nature 446:806-10. 2007
    ..This modification, in turn, enables a ubiquitin ligase complex containing the cullin Rtt101 to ensure genomic integrity during DNA replication...
  82. pmc The mating-type chromosome in the filamentous ascomycete Neurospora tetrasperma represents a model for early evolution of sex chromosomes
    Audrius Menkis
    Department of Forest Mycology and Pathology, Swedish University of Agricultural Sciences, Uppsala, Sweden
    PLoS Genet 4:e1000030. 2008
    ..tetrasperma involved more than one evolutionary event, covers the majority of the mating-type chromosome and is flanked by distal regions with obligate crossovers...
  83. pmc Meiotic recombination at the ends of chromosomes in Saccharomyces cerevisiae
    Arnold B Barton
    Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, International Center for Public Health, Newark, New Jersey 07101 1709, USA
    Genetics 179:1221-35. 2008
    ..Thus, the distribution of crossovers in S. cerevisiae appears to resemble that found in several higher eukaryotes where the outermost chromosomal regions show increased crossing over...
  84. pmc Evolution and organization of a highly dynamic, subtelomeric helicase gene family in the rice blast fungus Magnaporthe grisea
    Weimin Gao
    Department of Plant Pathology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 162:103-12. 2002
    ....
  85. pmc Pch2 links chromosome axis remodeling at future crossover sites and crossover distribution during yeast meiosis
    Neeraj Joshi
    Department of Biological, Geological, and Environmental Sciences, Center for Gene Regulation in Health and Disease, Cleveland State University, Cleveland, Ohio, United States of America
    PLoS Genet 5:e1000557. 2009
    ..Pch2 is proposed to reorganize chromosome axes into a tiling array of long-range crossover control modules, resulting in chiasma formation at minimum levels and with maximum spacing...
  86. ncbi Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery
    R V Skibbens
    Carnegie Institute of Washington, Department of Embryology, Baltimore, Maryland 21210, USA
    Annu Rev Genet 32:307-37. 1998
    ..Throughout this review we focus on budding yeast but reference parallel processes found in other organisms...
  87. pmc Sgs1 and exo1 redundantly inhibit break-induced replication and de novo telomere addition at broken chromosome ends
    John R Lydeard
    Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America
    PLoS Genet 6:e1000973. 2010
    ..The severe constraint on 5' to 3' resection, which also abrogates activation of the Mec1-dependent DNA damage checkpoint, permits an unprecedented level of new telomere addition...
  88. pmc Formation of new chromosomes as a virulence mechanism in yeast Candida glabrata
    Silvia Polakova
    Department of Cell and Organism Biology, Lund University, SE 22362 Lund, Sweden
    Proc Natl Acad Sci U S A 106:2688-93. 2009
    ..We show that the observed genome plasticity is connected with antifungal drug resistance and it is likely an advantage in the human body, where environmental conditions fluctuate a lot...
  89. pmc Conservation of recombination hotspots in yeast
    Isheng J Tsai
    Division of Biology, Imperial College London, Silwood Park, Ascot, Berks SL5 7PY, United Kingdom
    Proc Natl Acad Sci U S A 107:7847-52. 2010
    ..Thus, recombination hotspots are not inevitably short-lived, but rather their persistence through evolutionary time will be determined by the frequency of outcrossing events in the life cycle...
  90. pmc Apn1 and Apn2 endonucleases prevent accumulation of repair-associated DNA breaks in budding yeast as revealed by direct chromosomal analysis
    Wenjian Ma
    Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences NIH, DHHS, Research Triangle Park, NC 27709, USA
    Nucleic Acids Res 36:1836-46. 2008
    ..This approach provided direct physical evidence that Apn1 and Apn2 not only repair cellular base damage but also prevent break accumulation that can result from AP sites being channeled into other BER pathway(s)...
  91. pmc Cell-cycle regulation of cohesin stability along fission yeast chromosomes
    Pascal Bernard
    Universite Bordeaux 2, CNRS Institut de Biochimie et Génétique Cellulaires, Bordeaux, France
    EMBO J 27:111-21. 2008
    ..Hence, cohesin stabilization might be a pre-requisite for cohesion establishment rather than its consequence...
  92. pmc Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage
    John Rouse
    MRC Protein Phosphorylation Unit, Wellcome Trust Biocentre Medical Sciences Institute, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 23:1188-97. 2004
    ..These results identify Esc4p as an important new S-phase-specific target of Mec1p...
  93. pmc Chromosome looping in yeast: telomere pairing and coordinated movement reflect anchoring efficiency and territorial organization
    Kerstin Bystricky
    Department of Molecular Biology and NCCR Frontiers in Genetics, University of Geneva, 1211 Geneva 4, Switzerland
    J Cell Biol 168:375-87. 2005
    ..These mutations do not, however, eliminate coordinated movement of telomere (Tel) 6R and Tel6L, which we propose stems from the territorial organization of yeast chromosomes...
  94. ncbi Functional genomics identifies monopolin: a kinetochore protein required for segregation of homologs during meiosis i
    A Toth
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, Vienna, Austria A 1030
    Cell 103:1155-68. 2000
    ..We conclude that monopolar attachment during meiosis I requires at least one meiosis-specific protein and is independent of the process that protects sister centromere cohesion...
  95. ncbi Supernumerary chromosomes in filamentous fungi
    S F Covert
    Daniel B Warnell School of Forest Resources, University of Georgia, Athens, GA 30602 2152, USA
    Curr Genet 33:311-9. 1998
    ....
  96. ncbi Phosphorylation of the axial element protein Hop1 by Mec1/Tel1 ensures meiotic interhomolog recombination
    Jesús A Carballo
    Division of Stem Cell Biology and Developmental Genetics, MRC National Institute for Medical Research, London NW7 1AA, UK
    Cell 132:758-70. 2008
    ..Thus, Hop1 is a meiosis-specific adaptor protein of the Mec1/Tel1 signaling pathway that ensures interhomolog recombination by preventing Dmc1-independent repair of meiotic DSBs...
  97. pmc A novel role for the mitotic spindle during DNA segregation in yeast: promoting 2 microm plasmid-cohesin association
    Shwetal Mehta
    Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, TX 78712, USA
    Mol Cell Biol 25:4283-98. 2005
    ..These results are consistent with a model in which the spindle promotes plasmid segregation in a chromosome-linked fashion...
  98. pmc A conditionally dispensable chromosome controls host-specific pathogenicity in the fungal plant pathogen Alternaria alternata
    Rieko Hatta
    Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya, Japan
    Genetics 161:59-70. 2002
    ..05-Mb chromosome encoding the AFT genes. This chromosome was not essential for saprophytic growth of this pathogen. Thus, we propose that a conditionally dispensable chromosome controls host-specific pathogenicity of this pathogen...
  99. ncbi The Dam1/DASH complex is required for the retrieval of unclustered kinetochores in fission yeast
    Alejandro Franco
    Division of Yeast Genetics, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    J Cell Sci 120:3345-51. 2007
    ..These data provide the first direct evidence that the Dam1/DASH complex can couple the force generated by microtubule depolymerisation to direct chromosome movement in vivo...
  100. pmc Shugoshin promotes sister kinetochore biorientation in Saccharomyces cerevisiae
    Brendan M Kiburz
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Biol Cell 19:1199-209. 2008
    ..In contrast, Sgo1 is important to bias sister kinetochores toward biorientation. We suggest that Sgo1 acts at sister kinetochores to promote their biorientation...
  101. pmc Single Holliday junctions are intermediates of meiotic recombination
    Gareth A Cromie
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, P O Box 19024, Seattle, WA 98109, USA
    Cell 127:1167-78. 2006
    ....

Research Grants35

  1. IN VITRO RECONSTRUCTION OF FUNGAL CHROMOSOMES
    Jonathan Arnold; Fiscal Year: 1993
  2. RECOMBINATION MECHANISMS IN YEAST CELL DIFFERENTIATION
    James Haber; Fiscal Year: 2006
    ..abstract_text> ..
  3. Activating liver carcinogens in yeast by expressing CYP450 polymorphisms
    Michael Fasullo; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  4. RADIATION INDUCTION OF GENOMIC REARRANGEMENTS IN YEAST
    Michael Fasullo; Fiscal Year: 2004
    ..abstract_text> ..
  5. Assembling a Centric Nucleosome
    Richard Baker; Fiscal Year: 2004
    ..Given the high conservation of centric histone H3 variants throughout evolution, the results will illuminate the problem of centromere formation and function in higher eukaryotes including humans. ..
  6. Gene Expression and the Nuclear Pore Complex
    David Drubin; Fiscal Year: 2007
    ..Completion of this proposal will provide a more thorough understanding of gene expression and its regulation in eukaryotic cells. [unreadable] [unreadable]..
  7. "Calling Cards" for DNA-binding proteins: A tool for their genome-wide mapping
    ROBI MITRA; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  8. GPCR signaling cascades in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. Genetic analysis of Cryptococcus neoformans virulence
    Joseph Heitman; Fiscal Year: 2009
    ..These studies will enable a genome-wide definition of the gene set contributing to virulence of this common human fungal pathogen. ..
  10. Epigenetic Regulation of the Embryonic Germ Line
    William Kelly; Fiscal Year: 2009
    ..This could also provide a better foundation for understanding how pluripotency is achieved and hopefully lead to therapies involving somatic stem cells. ..
  11. Regulation of Chromosome Segregation in Human Cells
    Prasad Jallepalli; Fiscal Year: 2009
    ..Such information is essential to developing more effective cancer therapies that attack the CIN phenotype found in most cancer cells. ..
  12. Genetic Silencing in Germline Maintenance and Function
    William G Kelly; Fiscal Year: 2010
    ..Epigenetic mechanisms operating in the germ line are essential for the establishment of imprinting and the prevention of heritable genetic mutations, both of which are crucial for normal human health and normal human development. ..
  13. Genetics of mating and fruiting in Cryptococcus neoformans
    Joseph Heitman; Fiscal Year: 2010
    ..neoformans and C. gattii applicable to development of treatment approaches, diagnostics, or environmental interventions to reduce exposure to infectious spores. ..
  14. Biochemistry of recombination in gametogenesis
    Wayne P Wahls; Fiscal Year: 2010
    ....
  15. Role of Calcineurin in Fungal Virulence
    Joseph Heitman; Fiscal Year: 2009
    ..Importantly, this pathway can be targeted for therapeutic intervention using non-immunosuppressive calcineurin inhibitors that retain antifungal activity and synergistic drug combinations that we have discovered. ..
  16. MOLECULAR ANALYSIS OF MICROTUBULE FUNCTION IN YEAST
    Tim C Huffaker; Fiscal Year: 2010
    ..We have developed all of the necessary assays in preliminary studies with Bim1 and Bik1. We now plan to expand these studies by including Stu1 and Stu2. ..
  17. 2003 Genetic Toxicology Gordon Conference
    Anthony Carr; Fiscal Year: 2007
    ..We particularly air to obtain funding to support applications from minority groupings and younger scientists. We have already identified a significant participation of women amongst our list of speakers. ..
  18. Mechanism of Meclp in the Checkpoint Response
    GEORGE BRUSH; Fiscal Year: 2006
    ..It is expected that these studies will provide significant insight into the molecular mechanisms underlying maintenance of the non-cancerous state under genotoxic conditions. ..
  19. MICROARRAY EQUIPMENT
    Bruce Futcher; Fiscal Year: 2001
    ..Resources for more extensive data analysis would be available on the facility's Web site. The operation of the facility would be supported by user charges of about $75 per array experiment. ..
  20. ENTAMOEBA HISTOLYTICA GENOME PROJECT
    Brendan Loftus; Fiscal Year: 2002
    ..The vast majority of the research needs and applications will be met by obtaining 99 percent of the genomic sequence. ..
  21. KU COMPLEX AND TELOMERE END PROTECTION
    ALISON BERTUCH; Fiscal Year: 2003
    ..Dr. Lundblad's laboratory in the Department of Molecular and Human Genetics at the Baylor College of Medicine provides an excellent environment in which to develop my scientific skills. ..
  22. SPINDLE POLES AND NUCLEAR PORES--YEAST NDC1 AND MPS2
    Mark Winey; Fiscal Year: 2003
    ..The proposed project is aimed at understanding the function of a set of unusual membrane proteins at the SPB and the NPC, and at identifying other proteins with which the interact at these organelles. ..
  23. REGULATION OF MEIOTIC DEVELOPMENT BY MTS1-MTS2 PROTEIN
    WAYNE WAHLS; Fiscal Year: 2004
    ..4) To test alternative hypotheses that the Mts1-Mts2-M26 complex either enhances the use of a pre-existing recombinational initiation site or creates a new initiation site. The PI request four years of support to carry out this study. ..
  24. Chromatin-Mediated Mechanisms of Gene Repression
    Laura N Rusche; Fiscal Year: 2010
    ..abstract_text> ..
  25. Tetrahymena Basal Body Duplication
    Mark Winey; Fiscal Year: 2004
    ....
  26. Molecular Structure of Yeast Chromosome 1
    DAVID KABACK; Fiscal Year: 2005
    ..abstract_text> ..
  27. Combinatoial CREB/ATF dimers and cellular growth control
    WAYNE WAHLS; Fiscal Year: 2004
    ..Aim 3, To further characterize regulatory mechanisms for stress responses mediated by the Mts1 bZIP protein: elucidate the role of the MAP kinase Spcl in controlling an autoinhibitory function of Mts1. ..
  28. Karyotypes of C. albicans fluconzole resistant mutants
    Elena Rustchenko; Fiscal Year: 2004
    ..abstract_text> ..
  29. The Rate and Molecular Spectrum of Spontaneous Mutations
    Michael Lynch; Fiscal Year: 2009
    ....
  30. REVERSAL OF DNA DAMAGE BY ALTERNATIVE EXCISION REPAIR
    PAUL DOETSCH; Fiscal Year: 2005
    ..Biochemical characterization of the components of the AER pathway and potentially related pathways will continue as well as studies aimed at determining the range of organisms which utilize Uve1p-like proteins for DNA repair. ..
  31. Winship Cancer Institute, Emory University
    PAUL DOETSCH; Fiscal Year: 2007
    ..abstract_text> ..
  32. Analysis of the Yeast Cell Cycle Transcriptional Program
    ALLEN FUTCHER; Fiscal Year: 2008
    ..In Aim 3, we will test the hypothesis that an oscillation in the state of histone acetylation is a major mechanism of cell cycle transcriptional control. [unreadable] [unreadable]..
  33. NEGATIVE REGULATION OF CELL CYCLE PROGRESSION
    M Hoyt; Fiscal Year: 2004
    ..The identified genes will report checkpoint activation and will allow a powerful dissection of this signal transduction pathway. ..
  34. TRANSCRIPTIONAL MUTAGENESIS BY IONIZING RADIATION
    PAUL DOETSCH; Fiscal Year: 2002
    ..The in vivo studies will address whether or not such mutagenic insertions occurring at the level of transcription can alter protein expression in a non-dividing cell. ..