nucleolus organizer region

Summary

Summary: The chromosome region which is active in nucleolus formation and which functions in the synthesis of ribosomal RNA.

Top Publications

  1. pmc UBF binding in vivo is not restricted to regulatory sequences within the vertebrate ribosomal DNA repeat
    Audrey C O'Sullivan
    Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Mol Cell Biol 22:657-68. 2002
  2. ncbi AgNOR staining and quantification
    D Trere
    Department of Experimental Pathology, University of Bologna, Italy
    Micron 31:127-31. 2000
  3. ncbi Chromosomal differentiation of Hyla nana and Hyla sanborni (Anura, Hylidae) with a description of NOR polymorphism in H. nana
    L R Medeiros
    Departamento de Biologia Celular, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, 13084 971 Campinas, Sao Paulo, Brazil
    J Hered 94:149-54. 2003
  4. ncbi Cytogenetic analysis of two species in the Phyllomedusa hypochondrialis group (Anura, Hylidae)
    Daniel Pacheco Bruschi
    Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, SP, Brazil
    Hereditas 149:34-40. 2012
  5. pmc Nucleolar assembly of the rRNA processing machinery in living cells
    T M Savino
    Institut Jacques Monod, UMR 7592, 2 place Jussieu, 75251 Paris Cedex 05, France
    J Cell Biol 153:1097-110. 2001
  6. ncbi Evolutionary dynamics of rDNA clusters on chromosomes of moths and butterflies (Lepidoptera)
    Petr Nguyen
    Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech
    Genetica 138:343-354. 2010
  7. ncbi The epigenetics of rRNA genes: from molecular to chromosome biology
    Brian McStay
    Biomedical Research Center, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, United Kingdom
    Annu Rev Cell Dev Biol 24:131-57. 2008
  8. ncbi Location and expression of ribosomal RNA genes in grasshoppers: abundance of silent and cryptic loci
    Josefa Cabrero
    Departamento de Genetica, Facultad de Ciencias, Universidad de Granada, 18071, Granada, Spain
    Chromosome Res 16:595-607. 2008
  9. ncbi When rDNA transcription is arrested during mitosis, UBF is still associated with non-condensed rDNA
    J Gebrane-Younes
    Institut Jacques Monod, Paris, France
    J Cell Sci 110:2429-40. 1997
  10. ncbi Polymorphism of the nucleolus organizer region (NOR) on the putative sex chromosomes of Arctic char (Salvelinus alpinus) is not sex related
    K M Reed
    Department of Biological Sciences, University of Wisconsin Milwaukee 53201, USA
    Chromosome Res 5:221-7. 1997

Research Grants

  1. RNA PROCESSING AND RIBONUCLEOPROTEIN
    Thoru Pederson; Fiscal Year: 2001
  2. PERINUCLEOLAR COMPARTMENT AND CANCER
    Sui Huang; Fiscal Year: 2003
  3. The Perinucleolar Compartment as Breast Cancer Marker
    Sui Huang; Fiscal Year: 2005
  4. RNA Transport Within the Nucleus
    Thoru Pederson; Fiscal Year: 2005
  5. A Novel HTP Assay for Identification of Compounds that Reduce PNC Prevalence
    Sui Huang; Fiscal Year: 2008
  6. TUMOR VACCINES FOR THE TREATMENT OF ORAL MELANOMA
    David Vail; Fiscal Year: 2002
  7. AUTOANTIGEN RNA HELICASE II/GU
    Benigno Valdez; Fiscal Year: 2003
  8. Characterization of p53-independent ARF pathway
    Jason Weber; Fiscal Year: 2007

Detail Information

Publications184 found, 100 shown here

  1. pmc UBF binding in vivo is not restricted to regulatory sequences within the vertebrate ribosomal DNA repeat
    Audrey C O'Sullivan
    Biomedical Research Centre, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Mol Cell Biol 22:657-68. 2002
    ..These results are consistent with a structural role for UBF at active nucleolar organizer regions in addition to its recognized role in stable transcription complex formation at the promoter...
  2. ncbi AgNOR staining and quantification
    D Trere
    Department of Experimental Pathology, University of Bologna, Italy
    Micron 31:127-31. 2000
    ..The present paper discusses the main technical aspects of NOR silver-staining, and critically evaluates the methods commonly employed for AgNOR protein quantification in routine cyto-histopathology...
  3. ncbi Chromosomal differentiation of Hyla nana and Hyla sanborni (Anura, Hylidae) with a description of NOR polymorphism in H. nana
    L R Medeiros
    Departamento de Biologia Celular, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, 13084 971 Campinas, Sao Paulo, Brazil
    J Hered 94:149-54. 2003
    ..However, the chromosomal morphology of both species differed from that reported for populations from other geographic regions, suggesting that a systematic reevaluation of this group of Hyla may be necessary...
  4. ncbi Cytogenetic analysis of two species in the Phyllomedusa hypochondrialis group (Anura, Hylidae)
    Daniel Pacheco Bruschi
    Departamento de Biologia Estrutural e Funcional, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, Campinas, SP, Brazil
    Hereditas 149:34-40. 2012
    ..The nucleolus organizer region (NOR) was detected in pair 9 of both species, but is located in the pericentromeric region of the short ..
  5. pmc Nucleolar assembly of the rRNA processing machinery in living cells
    T M Savino
    Institut Jacques Monod, UMR 7592, 2 place Jussieu, 75251 Paris Cedex 05, France
    J Cell Biol 153:1097-110. 2001
    ..This demonstrates the formation of one functional domain by cooperative interactions between different chromosome territories...
  6. ncbi Evolutionary dynamics of rDNA clusters on chromosomes of moths and butterflies (Lepidoptera)
    Petr Nguyen
    Faculty of Science, University of South Bohemia, Ceske Budejovice, Czech
    Genetica 138:343-354. 2010
    ..e., homologous recombination between repetitive sequences of non-homologous chromosomes, as a primary motive force in rDNA repatterning...
  7. ncbi The epigenetics of rRNA genes: from molecular to chromosome biology
    Brian McStay
    Biomedical Research Center, Ninewells Hospital, University of Dundee, Dundee DD1 9SY, United Kingdom
    Annu Rev Cell Dev Biol 24:131-57. 2008
    ..We also review the critical role of the RNA polymerase I transcription factor UBF in the formation of active nucleolar organizer regions (NORs) and maintenance of the euchromatic state of rRNA genes...
  8. ncbi Location and expression of ribosomal RNA genes in grasshoppers: abundance of silent and cryptic loci
    Josefa Cabrero
    Departamento de Genetica, Facultad de Ciencias, Universidad de Granada, 18071, Granada, Spain
    Chromosome Res 16:595-607. 2008
    ..The cryptic NORs might correspond to nascent NORs, i.e. a few rRNA gene copies moved to new locations, whereas the inactive rDNA loci might correspond to those being in the process of elimination...
  9. ncbi When rDNA transcription is arrested during mitosis, UBF is still associated with non-condensed rDNA
    J Gebrane-Younes
    Institut Jacques Monod, Paris, France
    J Cell Sci 110:2429-40. 1997
    ..It is proposed that modifications of the transcription machinery occurring in prometaphase could explain the arrest of transcription, while reverse modifications in late anaphase could explain activation...
  10. ncbi Polymorphism of the nucleolus organizer region (NOR) on the putative sex chromosomes of Arctic char (Salvelinus alpinus) is not sex related
    K M Reed
    Department of Biological Sciences, University of Wisconsin Milwaukee 53201, USA
    Chromosome Res 5:221-7. 1997
    Polymorphism of the nucleolus organizer region (NOR) on the putative sex chromosomes of Arctic char (Salvelinus alpinus) was examined using conventional cytogenetic and molecular techniques...
  11. ncbi Evolutionary aspects of the ZZ/ZW sex chromosome system in the Characidae fish, genus Triportheus. A monophyletic state and NOR location on the W chromosome
    R F Artoni
    Universidade Estadual de Ponta Grossa, Campus de Uvaranas, Departamento de Biologia Geral, 84030 900 Ponta Grossa, PR, Brazil
    Heredity (Edinb) 89:15-9. 2002
    ..The location of rRNA genes on this chromosome may correspond to a plesiomorphic condition in the genus and, if so, predates to the sex chromosome system differentiation, with a possible influence in the initial steps of this process...
  12. ncbi Nucleolus: from structure to dynamics
    Danièle Hernandez-Verdun
    Nuclei and Cell Cycle, Institut Jacques Monod, CNRS, Université Paris VI et Paris VII, 2 place Jussieu, 75251, Paris, Cedex 05, France
    Histochem Cell Biol 125:127-37. 2006
    ..Time-lapse analysis of fluorescence resonance energy transfer demonstrates that processing complexes are formed in PNBs. Finally, the nucleolus appears at the center of several trafficking pathways in the nucleus...
  13. ncbi Phylogenetic position of the saola (Pseudoryx nghetinhensis) inferred from cytogenetic analysis of eleven species of Bovidae
    T T Nguyen
    UMR 5202 Origine, Structure et Evolution de la Biodiversité, Departement Systematique et Evolution, Museum national d histoire naturelle, Paris, France
    Cytogenet Genome Res 122:41-54. 2008
    ..These findings suggest that NORs are an important and frequently overlooked source of additional phylogenetic information within the Bovidae that may also have applicability at higher taxonomic levels, possibly even for Pecora...
  14. pmc Multimegabase silencing in nucleolar dominance involves siRNA-directed DNA methylation and specific methylcytosine-binding proteins
    SASHA B PREUSS
    Biology Department, Washington University, St Louis, MO 63130, USA
    Mol Cell 32:673-84. 2008
    ....
  15. ncbi Genome restructuring in rye affects the expression, organization and disposition of homologous rDNA loci
    Ana D Caperta
    Secção de Genética, Departamento de Botanica e Engenharia Biologica, Instituto Superior de Agronomia, Tapada da Ajuda, 1349 017 Lisboa, Portugal
    J Cell Sci 115:2839-46. 2002
    ..These results seem to indicate a 'sequence recognition' process for the regulation of homologous loci...
  16. ncbi Relationships between transcription, silver staining, and chromatin organization of nucleolar organizers in Secale cereale
    Ana D Caperta
    Centro Botânica Aplicada à Agricultura, Instituto Superior de Agronomia, Technical University of Lisbon, Lisboa
    Protoplasma 232:55-9. 2007
    ..Collectively, these results suggest that rRNA gene transcription, silver staining, and NOR decondensation are interrelated in S. cereale...
  17. ncbi The mitotically phosphorylated form of the transcription termination factor TTF-1 is associated with the repressed rDNA transcription machinery
    V Sirri
    Institut Jacques Monod, UMR 7592, Paris, France
    J Cell Sci 112:3259-68. 1999
    ..The reorganization of the mitotic rDNA promoter might be induced by phosphorylation of certain components of the rDNA transcription machinery and participate in silencing of rDNA during mitosis...
  18. ncbi ASE-1: a novel protein of the fibrillar centres of the nucleolus and nucleolus organizer region of mitotic chromosomes
    C M Whitehead
    Department of Anatomy, The University of Calgary, 3330 Hospital Drive N W, Calgary, Alberta, Canada T2N 4N1
    Chromosoma 106:493-502. 1997
    ..ASE-1 co-localises with the RNA polymerase I transcription initiation factor UBF/NOR-90 throughout all stages of the cell cycle and these two proteins associate with each other in vitro...
  19. ncbi Chromosomal characteristics of rDNA in European grayling Thymallus thymallus (Salmonidae)
    M Jankun
    Department of Evolutionary Ecology, University WM in Olsztyn, 10 718 Olsztyn Kortowo, Poland
    Genetica 119:219-24. 2003
    ..Double variable pattern in the number and location of NORs supported the bi-directional evolution of salmonid rDNA loci...
  20. pmc Genetic linkage map of the nucleolus organizer region in the soybean
    Kiwoung Yang
    Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Republic of Korea
    Genetics 178:605-8. 2008
    Simple polymorphisms in ribosomal DNA repeats in the nucleolus organizer region (NOR) permitted the development of markers for the genetic mapping of the soybean NOR...
  21. pmc Chromosomal dynamics of nucleolar organizer regions (NORs) in the house mouse: micro-evolutionary insights
    J Britton-Davidian
    Institut des Sciences de l Evolution, Universite Montpellier 2, Montpellier Cedex, France
    Heredity (Edinb) 108:68-74. 2012
    ..Such a scenario provides an alternative view from the one prevailing in most systematic and phylogenetic analyses that NORs have a high transposition rate due to concerted evolution of rRNA genes...
  22. ncbi Chromosomal differentiation of populations of Lysapsus limellus limellus, L. l. bolivianus, and of Lysapsus caraya (Hylinae, Hylidae)
    Carmen Silvia Busin
    Departamento de Biologia Celular, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, 13083 863 Campinas, SP, Brazil
    Micron 37:355-62. 2006
    ..l. bolivianus and in pair 7 in L. caraya. These results suggest that a reassessment of the taxonomic status of L. limellus subspecies, especially of the L. l. bolivianus populations, may be necessary...
  23. pmc UBF-binding site arrays form pseudo-NORs and sequester the RNA polymerase I transcription machinery
    Christine Mais
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY Scotland, United Kingdom
    Genes Dev 19:50-64. 2005
    ..Furthermore, we propose that UBF mediates recruitment of the pol I machinery to nucleoli independently of promoter elements...
  24. ncbi New insights into nucleolar architecture and activity
    Ivan Raska
    Institute of Cellular Biology and Pathology, First Faculty of Medicine, Charles University in Prague, Czech Republic
    Int Rev Cytol 255:177-235. 2006
    ..However, the present power of light and electron microscopy (EM) techniques means that a description of nucleolar processes at the molecular level is now achievable, and the time is ripe for such an effort...
  25. ncbi Holocentric chromosomes of Luzula elegans are characterized by a longitudinal centromere groove, chromosome bending, and a terminal nucleolus organizer region
    S Heckmann
    Leibniz Institute of Plant Genetics and Crop Plant Research IPK, Gatersleben, Germany
    Cytogenet Genome Res 134:220-8. 2011
    ..We suggest that the 45S rDNA position in distal centromere-free regions could be required to ensure chromosome stability...
  26. ncbi Usefulness of AgNOR counts in diagnosing epithelial dysplasia
    Jay G Ray
    Department of Oral Pathology and Microbiology, Dr R Ahmed Dental College and, Hospital, Kolkata, India
    J Oral Pathol Med 32:71-6. 2003
    ..Diagnosis of epithelial dysplasia has traditionally been subjective, and there is a need for a quantifiable and useful test...
  27. ncbi Evaluation of argyrophilic nucleolar organizer regions in tongue squamous cell carcinomas
    L Yue
    Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan
    Oral Oncol 35:70-6. 1999
    ..0%), with a significant difference between the two groups (P < 0.05). The results suggest that AgNORs may reflect the degree of malignancy and cellular proliferation in tongue SCCs...
  28. ncbi AgNOR cut-point to distinguish mild and moderate epithelial dysplasia
    Amit Chattopadhyay
    Department of Epidemiology, University of Kentucky College of Public Health, Lexington, KY 40536, USA
    J Oral Pathol Med 37:78-82. 2008
    ..We demonstrated earlier that silver-stainable nucleolar organizer region (AgNOR) is a simple, inexpensive and quantifiable method which can standardize this distinction reliably...
  29. ncbi Argyrophilic proteins of nucleolar organizer regions (AgNORs) in salivary gland mucoepidermoid carcinoma and its relation to histological grade
    Mojgan Alaeddini
    Dental Research Center, Medical Sciences University of Tehran, Tehran, Iran
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:758-62. 2008
    ..The aim of this study was to assess the cellular proliferation rate of major and minor salivary gland mucoepidermoid carcinomas (MECs) by quantitative analysis of AgNOR and to determine its relation to histopathologic grading...
  30. ncbi Actual Proliferating Index and p53 protein expression as prognostic marker in odontogenic cysts
    A R Gadbail
    Department of Oral and Maxillofacial Pathology and Microbiology, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Medical Sciences, Sawangi M, Wardha, Maharashtra 442001, India
    Oral Dis 15:490-8. 2009
    ....
  31. ncbi A study of the utility of silver nucleolar organizer regions in categorization and prognosis of salivary gland tumors
    Bukola F Adeyemi
    Department of Oral Pathology, University College Hospital, Ibadan, Nigeria
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:513-20. 2006
    ..this study aimed at assessing the utility of silver nucleolar organizer region (AgNOR) staining in categorization and prognostication of salivary gland tumors...
  32. ncbi Nucleolar organizer regions in selected odontogenic lesions
    Behnam Eslami
    Shahid Beheshti University of Medical Sciences and Dental Research Center of Iran, Tehran, Iran
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:187-92. 2003
    ..The present study aimed to assess the usefulness of argyrophilic nucleolar organizer regions (AgNORs) as quantitative criteria in the diagnosis of odontogenic cysts and tumors...
  33. pmc Postembryonic establishment of megabase-scale gene silencing in nucleolar dominance
    Olga Pontes
    Department of Biology, Washington University, St Louis, Missouri, United States of America
    PLoS ONE 2:e1157. 2007
    ..thaliana NORs is disrupted. Collectively, these data demonstrate that HDA6 and HDT1 function in the postembryonic establishment of nucleolar dominance, a process which recurs in each generation...
  34. ncbi Prognostic significance of DNA cytometry in combination with AgNOR investigation
    Marijana Coric
    Institute of Pathology, Medical School University of Zagreb, Zagreb, Croatia
    Acta Otolaryngol 127:1332-7. 2007
    ..The observed intratumoral heterogeneity could represent a possible source of conflicting and inconsistent results...
  35. ncbi NOR polymorphism in the Iberian species Chondrostoma lusitanicum (Pisces: Cyprinidae)--re-examination by FISH
    M J Collares-Pereira
    Centro de Biologia Ambiental Departamento de Zoologia e Antropologia, Faculdade de Ciencias, Lisboa, Portugal
    Genetica 105:301-3. 1999
    ..The absence of individuals heterozygous for this polymorphism is discussed...
  36. ncbi Behaviour of nucleolus organizing regions (NORs) and nucleoli during mitotic and meiotic divisions in budding yeast
    Jörg Fuchs
    Institute of Botany, University of Vienna, Rennweg 14, A 1030 Vienna, Austria
    Chromosome Res 12:427-38. 2004
    ..We discuss the possibility that the exclusion of the nucleolus from the spores serves the disposal of agents that resort to the nucleolus, and has a role in spore dormancy or rejuvenation...
  37. pmc Quantitative kinetic analysis of nucleolar breakdown and reassembly during mitosis in live human cells
    Anthony Kar Lun Leung
    Division of Gene Regulation and Expression, School of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK
    J Cell Biol 166:787-800. 2004
    ....
  38. ncbi Chromatin turn ons and turn offs of ribosomal RNA genes
    Richard J Lawrence
    Biology Department, Washington University, St Louis, Missouri 63130, USA
    Cell Cycle 3:880-3. 2004
    ..Independent studies using mouse and human cells have led to similar conclusions, implicating chromatin modifications as important components of the regulatory networks that control the effective dosage of active rRNA genes...
  39. ncbi Nucleolar dominance: uniparental gene silencing on a multi-megabase scale in genetic hybrids
    C S Pikaard
    Biology Department, Washington University, St Louis, MO 63130, USA
    Plant Mol Biol 43:163-77. 2000
    ..This review provides a historical perspective of nucleolar dominance research, explores the most popular hypotheses and their shortcomings, and offers some speculations concerning alternative hypotheses to be considered...
  40. pmc Chromosomal locus rearrangements are a rapid response to formation of the allotetraploid Arabidopsis suecica genome
    Olga Pontes
    Centro de Botaānica Aplicada à Agricultura, Instituto Superior de Agronomia, Tapada da Ajuda, 1349 017 Lisbon, Portugal
    Proc Natl Acad Sci U S A 101:18240-5. 2004
    ..Fluorescence in situ hybridization with centromere, nucleolus organizer region (NOR), and 5S rRNA gene probes reveals the expected numbers of progenitor chromosomes in natural A...
  41. ncbi A Drosophila rRNA gene located in euchromatin is active in transcription and nucleolus formation
    G H Karpen
    Department of Genetics, University of Washington, Seattle 98195
    Genes Dev 2:1745-63. 1988
    ..We conclude that 'nucleolar organizing activity' is an intrinsic property of the rDNA or its RNA products...
  42. ncbi Cadmium induction of lipid peroxidation and effects on root tip cells and antioxidant enzyme activities in Vicia faba L
    Shanshan Zhang
    Department of Biology, College of Chemistry and Life Sciences, Tianjin Normal University, 300387, Tianjin, People s Republic of China
    Ecotoxicology 18:814-23. 2009
    ..In roots, MDA content showed an upward trend with increasing of the duration of treatment at early time and then declined...
  43. ncbi The nucleolus. Playing by different rules?
    Peter Shaw
    Department of Cell and Developmental Biology, John Innes Centre, Colney Norwich, UK
    Cell Cycle 4:102-5. 2005
    ..This short review describes some of the features of the nucleolus and highlights recent progress in understanding this important, but enigmatic, nuclear structure...
  44. ncbi Chromosome territory arrangement and homologous pairing in nuclei of Arabidopsis thaliana are predominantly random except for NOR-bearing chromosomes
    Ales Pecinka
    Institute of Plant Genetics and Crop Plant Research IPK, Corrensstrasse 3, 06466 Gatersleben, Germany
    Chromosoma 113:258-69. 2004
    ..Nevertheless, in up to 31.5% of investigated Arabidopsis nuclei allelic sequences may share positions close enough for homologous recombination...
  45. pmc Locus-specific ribosomal RNA gene silencing in nucleolar dominance
    Michelle S Lewis
    Biology Department, Washington University, Saint Louis, Missouri, United States of America
    PLoS ONE 2:e815. 2007
    ..Collectively, our data suggest that rRNA gene activation can occur in a gene-autonomous fashion, independent of chromosomal location, whereas rRNA gene silencing in nucleolar dominance is locus-dependent...
  46. pmc Human acrocentric chromosomes with transcriptionally silent nucleolar organizer regions associate with nucleoli
    G J Sullivan
    Biomedical Research Centre, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, UK
    EMBO J 20:2867-74. 2001
    ..Incorporation of silent NORs into mature nucleoli raises interesting issues concerning the maintenance of the activity status of individual NORs...
  47. pmc Recruitment of factors linking transcription and processing of pre-rRNA to NOR chromatin is UBF-dependent and occurs independent of transcription in human cells
    José Luis Prieto
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY Scotland, United Kingdom
    Genes Dev 21:2041-54. 2007
    ..Taken together, these results highlight the importance of the specialized chromatin structure at active NORs in coordinating early events in ribosome biogenesis and nucleolar formation...
  48. ncbi Relationship between HER2 status and proliferation rate in breast cancer assessed by immunohistochemistry, fluorescence in situ hybridisation and standardised AgNOR analysis
    Agnes Bankfalvi
    Institute of Pathology, University of Muenster, D 48149 Muenster, Germany
    Int J Oncol 23:1285-92. 2003
    ..Moreover, in 2+ positive IHC cases, the AgNOR analysis may represent an additional tool to select patients as candidates for Herceptin therapy due to the strong negative predictor value...
  49. ncbi AgNOR analysis of atypical ductal hyperplasia and intraductal carcinoma of the breast
    H Guski
    Department of Pathology, Charite Hospital, Faculty of Medicine, Humboldt University of Berlin, Germany
    Anal Quant Cytol Histol 22:206-12. 2000
    ..To determine the diagnostic and prognostic value of argyrophilic nucleolar organizer regions (AgNORs) in atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and microinvasive ductal carcinoma (MDCA) of the breast...
  50. ncbi Nucleolar organizing regions in Crassostrea angulata: chromosomal location and polymorphism
    Ismael Cross
    Laboratorio de Genetica, Facultad de Ciencias del Mary Ambientales, Universidad de Cadiz, Poligono Rio San Pedro, E 11510, Puerto Real, Cadiz, Spain
    Genetica 119:65-74. 2003
    ..Moreover, presence of pollutants on the medium could be favoring the presence of two NORs per cell more than acting modifying expression on the NORs...
  51. pmc Human autoantibody to RNA polymerase I transcription factor hUBF. Molecular identity of nucleolus organizer region autoantigen NOR-90 and ribosomal RNA transcription upstream binding factor
    E K Chan
    W M Keck Autoimmune Disease Center, Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037
    J Exp Med 174:1239-44. 1991
    ..Furthermore, we identified a nucleolar transcription factor as a novel target for human autoimmune response...
  52. ncbi Use of meiotic FISH for identification of a new monosome in Gossypium hirsutum L
    Y Ji
    Department of Soil and Crop Sciences, Texas A and M University, College Station 77843, USA
    Genome 40:34-40. 1997
    ....
  53. pmc Prognostic value of histobiological factors (malignancy grading and AgNOR content) assessed at the invasive tumour front of oral squamous cell carcinomas
    J Piffko
    Department of Cranio Maxillofacial Surgery, University of Munster, Germany
    Br J Cancer 75:1543-6. 1997
    ..Proliferative activity, assessed by standardized AgNOR analysis, most probably represents one of the biological features underlying the usefulness of evaluating the invasive tumour front...
  54. pmc Evidence for nucleolus organizer regions as the units of regulation in nucleolar dominance in Arabidopsis thaliana interecotype hybrids
    Michelle S Lewis
    Biology Department, Washington University, St Louis, Missouri 63130, USA
    Genetics 167:931-9. 2004
    ..NOR2. Collectively, the data indicate that nucleolar dominance is a complex trait in which NORs, rather than individual rRNA genes, are the likely units of regulation...
  55. ncbi Significance of silver-stained nucleolar organizer regions in early diagnosis and prognosis of oral squamous cell carcinoma: a multivariate analysis
    K Raveendran Pillai
    Division corrected of Cytopathology, Regional Cancer Centre, Thiruvanathapuran, Kesala corrected India
    In Vivo 19:807-12. 2005
    ..Thus T3 and T4 tumours, with mean AgNOR counts more than 2.8, are aggressive and may exhibit resistance to current treatment protocols...
  56. ncbi Modification of wheat rDNA loci by rye B chromosomes: a chromatin organization model
    L Morais-Cecilio
    Departamento de Botanica e Engenharia Biologica, Instituto Superior de Agronomia, Lisboa, Portugal
    Chromosome Res 8:341-51. 2000
    ..A model is discussed which interprets the phenotypic effects of Bs generically, in nucleotypic terms, based of their being 'genetically inert' but 'chromosomally active'...
  57. ncbi The N-terminal domain anchors human topoisomerase I at fibrillar centers of nucleoli and nucleolar organizer regions of mitotic chromosomes
    Morten O Christensen
    Department of Clinical Chemistry, Medizinische Poliklinik, University of Wurzburg, Klinikstrasse 6 8, D 97070 Wurzburg, Germany
    J Biol Chem 277:35932-8. 2002
    ..Thus, it provides a steady association of topoisomerase I with the rDNA and with RNA polymerase I, which is maintained in a living cell during the entire cell cycle...
  58. ncbi Mapping of the 18S and 5S ribosomal RNA genes in the fish Prochilodus argenteus Agassiz, 1829 (Characiformes, Prochilodontidae)
    Terumi Hatanaka
    Departamento de Genetica e Evolucao, Universidade Federal de Sao Carlos, Rodovia Washington Luiz, km 235, Cx Postal 676, 13565 905 Sao Carlos, SP, Brazil
    Genetica 122:239-44. 2004
    ..Despite a lower karyotype diversification (2n = 54 and FN = 108) often observed among species of Prochilodontidae, variations involving both 45S and 5S rRNA genes could play an important role in their chromosome diversification...
  59. ncbi Nucleolar size and activity are related to pRb and p53 status in human breast cancer
    Davide Trere
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna, Italy
    J Histochem Cytochem 52:1601-7. 2004
    ....
  60. pmc Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis
    Alice Grob
    Institut Jacques Monod, UMR 7592 CNRS Universités Paris 6 et 7, 2 place Jussieu, 75251 Paris Cedex 05, France
    J Cell Sci 122:489-98. 2009
    ..As SIRT7 activity is required to resume rDNA transcription in telophase, we propose that this conformational modification regulates onset of rDNA transcription...
  61. ncbi Codling moth cytogenetics: karyotype, chromosomal location of rDNA, and molecular differentiation of sex chromosomes
    Iva Fuková
    Institute of Entomology ASCR, Ceske Budejovice, Czech Republic
    Genome 48:1083-92. 2005
    ..The demonstrated ways of W chromosome identification will facilitate the development of genetic sexing strains desirable for pest control using the sterile insect technique...
  62. pmc Restricted chromosomal silencing in nucleolar dominance
    M S Lewis
    Biology Department, Washington University, Campus Box 1137, One Brookings Drive, St. Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 98:14536-40. 2001
    ..gene silencing on a scale of millions of bp is known to be involved, but the full extent to which nucleolus organizer region (NOR)-bearing chromosomes are inactivated beyond the NORs is unknown...
  63. pmc NORs and their transcription competence during the cell cycle
    E Smirnov
    Institute of Cellular Biology and Pathology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Folia Biol (Praha) 52:59-70. 2006
    ..Applying premature chromosome condensation with calyculin A, we visualized individual NORs in interphase cells, and found the same pattern of competence as observed in the mitotic chromosomes...
  64. ncbi [The research on the karyotypes of six species in the genus Eremias from China]
    Xing Dai
    College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225 009, China
    Yi Chuan 26:669-75. 2004
    ..vermiculata is more advanced. Making specialties of E. vermiculata will help in building the phylogenic tree of Eremias. In both male and female of the species studied, the heteromorphic sex-chromosomes were not found...
  65. ncbi Comparative genomic in situ hybridization (cGISH) analysis on plant chromosomes revealed by labelled Arabidopsis DNA
    J F Zoller
    , Germany
    Chromosome Res 9:357-75. 2001
    ..The universal application of this fast and simple one-step fluorescence banding technique for plant cytogenetic and plant genome evolution is discussed...
  66. ncbi Condensed chromatin surface and NORs surface enhancement in mitogen-stimulated lymphocytes of Down syndrome patients
    H Demirtas
    Med. Biol. and Genetics Dept, Medical Faculty, Erciyes University, 38039, Kayseri, Turkey
    Ann Genet 44:77-82. 2001
    ..No statistical difference was observed between 12 healthy controls and 5 Robertsonian translocation type of DS Patients (where the two involved NORs are missing) when the two parameters were considered...
  67. ncbi Cytogenetic studies in bone marrow cells from Wistar rats in protein malnutrition
    S Olmos
    , , , , Universidad de Buenos Aires, Buenos Aires, Argentina
    Metabolism 50:1025-9. 2001
    ..We conclude from these results that severe protein deficiency at weaning alters several aspects of bone marrow cell proliferation and ribosomal gene activity as determined by the number of silver stained nucleolus organizer regions...
  68. ncbi Number and nuclear localisation of nucleoli in mammalian spermatocytes
    Soledad Berríos
    Programa Genética Humana, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Avenida Independencia 1027, Santiago 7, Chile
    Genetica 121:219-28. 2004
    ..Thus, the distribution of nucleoli within the nuclear space of spermatocytes is non-random and it is consistent with the existence of a species-specific meiotic nuclear architecture...
  69. ncbi Extensive polymorphism and chromosomal characteristics of ribosomal DNA in a loach fish, Cobitis vardarensis (Ostariophysi, Cobitidae) detected by different banding techniques and fluorescence in situ hybridization (FISH)
    M Rabova
    Laboratory of Fish Genetics, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Libechov, Czech Republic
    Genetica 111:413-22. 2001
    ..Very similar structural polymorphism with multiple NORs is expressed in the Danubian loach C. elongatoides indicating a close relationship between both species...
  70. ncbi NOR sites detected by Ag-dAPI staining of an unusual autosome chromosome of Bradysia hygida (Diptera:Sciaridae) colocalize with C-banded heterochromatic region
    Vanessa Pinatto Gaspar
    Departamento de Biologia Celular e Genetica, Universidade Estadual de Maringa, Parana, Brasil
    Genetica 114:57-61. 2002
    ..By Ag-DAPI staining, active nucleolus organizer region, NOR, was revealed associated to the constitutive heterochromatin in the end of the C autosome ..
  71. ncbi Cytogenetic variability in genus odontocheila (Coleoptera, Cicindelidae): karyotypes, C-banding, NORs and localisation of ribosomal genes of O. confusa and O. nodicornis
    S J R Proença
    Centro de Biologia Ambiental Departamento de Zoologia e Antropologia, Faculdade de Ciencias, Universidade de Lisboa, Portugal
    Genetica 114:237-45. 2002
    ..nodicornis with terminal positive C-bands. These results are discussed from the cytogenetic and evolutionary point of view...
  72. ncbi Localization of rRNA genes in Phyllostomidae bats reveals silent NORs in Artibeus cinereus
    Neide Santos
    Departamento de Genética CCB, Universidade Federal de Pernambuco, Cidade Universitaria, Recife, Pernambuco, 50732 970, Brazil
    Hereditas 136:137-43. 2002
    ..This suggests the occurrence of silent NORs in pair 9. Differences in the size and intensity of the hybridization signals were also observed in the pair 9 of A. cinereus...
  73. ncbi Comparative study of DNA synthesis and nucleolar organizer regions of sinusoid littoral cells in mouse regenerating liver
    Carlos A Martín
    Instituto de Embriologia, Biología e Histología Facultad de Ciencias Médicas UNLP Calle 60 y 120 1900 La Plata Argentina
    Biocell 29:33-8. 2005
    ..The results of our experiment demonstrate the existence of a strong correlation of DNA synthesis measured by BrdU immunohistochemistry and AgNORs numbers in sinusoid littoral cells from mouse regenerating liver...
  74. ncbi Comparative analysis of rDNA location in five Neotropical gomphocerine grasshopper species
    Vilma Loreto
    Departamento de Genetica, CCB, Universidade Federal de Pernambuco, Recife, Brasil
    Genetica 132:95-101. 2008
    ..Evolutionary mechanisms responsible for the observed interspecific variation in NOR location in this group are discussed...
  75. ncbi GC-rich heterochromatin in silver stained nucleolar organizer regions (NORs) fluoresces with Chromomycin A3 (CMA3) staining in three species of teleostean fishes (Pisces)
    Jayanta Kumar Das
    Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani 741 235, India
    Indian J Exp Biol 45:413-8. 2007
    ..More data utilizing such combined methodologies are warranted to understand the structural organization of fish chromosomes more precisely...
  76. ncbi Chromosomal location polymorphism of major rDNA sites in two Mediterranean populations of the killifish Aphanius fasciatus (Pisces: Cyprinodontidae)
    Roberto Vitturi
    Dipartimento di Biologia Animale, Universita di Palermo, Via Archirafi 18, 90123 Palermo, Italy
    Micron 36:243-6. 2005
    ..Moreover, overlapping of silver staining and FISH patterns demonstrated that all ribosomal genes were transcriptionally active in each specimen...
  77. ncbi NOR expression increases on metaphase chromosomes of Down syndrome lymphocytes in concordance with mitogen concentration in culture medium
    Nalan Imamoglu
    Department of Medical Biology, Medical Faculty, Erciyes University, Kayseri, Turkey
    Cytometry B Clin Cytom 66:36-9. 2005
    Regulation of nucleolus organizer region (NOR) expression in trisomy 21 (Down syndrome [DS]) cells is not fully explained...
  78. ncbi Karyotype and chromosomal characteristics of Ag-NOR sites and 5S rDNA in European smelt, Osmerus eperlanus
    K Ocalewicz
    Department of Ichthyology, University of Warmia and Mazury in Olsztyn, ul Oczapowskiego 5, 10 718 Olsztyn Kortowo, Poland
    Genetica 131:29-35. 2007
    ....
  79. ncbi Banding pattern of A and B chromosomes of Prochilodus lineatus (Characiformes, Prochilodontidae), with comments on B chromosomes evolution
    Roberto Ferreira Artoni
    Departamento de Biologia Estrutural, Molecular e Genética, Universidade Estadual de Ponta Grossa, Campus de Uvaranas, 84030 900, Ponta Grossa, PR, Brazil
    Genetica 127:277-84. 2006
    ..The present results indicate that the B chromosomes of P. lineatus should have an ancient origin, and have undergone a differential evolutionary pathway among distinct populations...
  80. ncbi Dictyostelium discoideum Hsp32 is a resident nucleolar heat-shock protein
    A M Moerman
    Cellular and Molecular Biology Graduate Training Program, St Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Chromosoma 107:145-54. 1998
    ..Hsp32 therefore retains ist nucleolar localization under prolonged heat shock conditions by associating with nucleolar components other than the rDNA or rRNA...
  81. ncbi Distribution of rDNA in the nucleus of Giardia lamblia: detection by Ag-I silver stain
    J Guo
    College of Life Science, Nanjing Normal University, Nanjing, 210097, P R China
    Biotech Histochem 80:31-4. 2005
    ..In the silver stained Giardia cells, no nucleolus was found, but a few silver grains were scattered in the nucleus. This suggests that the rDNA of Giardia does not form an NOR-like structure and that its nucleus is in a primitive state...
  82. ncbi Hydrocephaly, penoscrotal transposition, and digital anomalies associated with de novo pseudodicentric rearranged chromosome 13 characterized by classical cytogenetic methods and mBAND analysis
    Denise Maria Christofolini
    Departamento de Morfologia, Disciplina de Genetica, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
    Am J Med Genet A 140:1321-5. 2006
    ..Moreover, the delineation of monosomy 13q32 --> qter in this patient facilitates identification of the developmental genes responsible for the clinical features within this region of chromosome 13...
  83. ncbi Localization of rDNA sites in holocentric chromosomes of three species of triatomines (Heteroptera, Triatominae)
    Grasiela Dias de Campos Severi-Aguiar
    Departamento de Biologia, Instituto de Biociencias, Letras e Ciencias Exatas, IBILCE UNESP, 15054 000 Sao Jose do Rio Preto, SP, Brasil
    Genet Mol Res 4:704-9. 2005
    ....
  84. ncbi Robertsonian rearrangements and pericentric inversions in Scaridae fish (Perciformes)
    D C S Sena
    Departamento de Biologia Celular e Genetica, Universidade Federal do Rio Grande do Norte, Centro de Biociencias, Natal, RN, Brasil
    Genet Mol Res 6:575-80. 2007
    ....
  85. ncbi To the intranucleolar translocation of AgNORs in leukemic early granulocytic and plasmacytic precursors
    Karel Smetana
    Institute of Hematology and Blood Transfusion, U Nemocnice 1, Prague 2, 128 20, Czech Republic
    Histochem Cell Biol 125:165-70. 2006
    ..However, more studies in this direction are required in the future...
  86. ncbi Cytogenetic analysis of the neotropical spider Nephilengys cruentata (Araneomorphae, Tetragnathidae): standard staining nors, C-bands and base-specific fluorochromes
    D Araujo
    Universidade Estadual Paulista, UNESP, Instituto de Biociencias, Departamento de Biologia, Av 24A, 1515, CEP 13506 900, Rio Claro, SP, Brazil
    Braz J Biol 65:193-202. 2005
    ..In N. cruentata the fluorochromes DAPI/DA, DAPI/MM and CMA3/DA revealed that the constitutive heterochromatin is rich in AT bases and the NORs possess repetitive sequences of GC bases...
  87. ncbi The origin of the Chorthippus parallelus hybrid zone: chromosomal evidence of multiple refugia for Iberian populations
    J L Bella
    Departamento de Biologia, Facultad de Ciencias, Universidad Autonoma de Madrid, Madrid, Spain
    J Evol Biol 20:568-76. 2007
    ..The pattern of variation supports the hypotheses of multiple refugia for Iberian populations and that more hybrid zones exist between these chromosomal variants...
  88. ncbi Lack of correspondence between CMA3-, Ag-positive signals and 28S rDNA loci in two Iberian minnows (Teleostei, Cyprinidae) evidenced by sequential banding
    M Gromicho
    Universidade de Lisboa, Faculdade de Ciencias, Centro de Biologia Ambiental, Lisboa, Portugal
    Cytogenet Genome Res 109:507-11. 2005
    ..Care should then be taken in considering CMA3- and Ag-stained sites as NORs since their accuracy for that purpose may not always correspond to the expectations...
  89. ncbi [Activation of nucleolar organizers during in vitro cultivation of mouse R1 embryonic stem cells]
    E R Kunafina
    Ontogenez 36:102-9. 2005
    ..Based on the experimental and published data, it has been proposed that activation of ribosomal genes correlates in time with a decreased capacity of embryonic stem cells for pluripotent differentiation...
  90. ncbi A natural triploid in Trichomycterus davisi (Siluriformes, Trichomycteridae): mitotic and meiotic characterization by chromosome banding and synaptonemal complex analyses
    Luciana Andreia Borin
    Department of Cell Biology and Genetics, State University of Maringa, PR, Brazil
    Genetica 115:253-8. 2002
    ..Analysis of the synaptonemal complex (SC) by electronic microscopy shows that there is an incomplete pairing of the third set of chromosomes in the triploid individual...
  91. ncbi Preponderance of GC-rich sites in silver-stained nucleolus organizing regions of Rita rita (Hamilton) and Mystus gulio (Hamilton) (Bagridae, Pisces), as revealed by chromomycin A3-staining technique and scanning electron microscopic studies
    J K Das
    Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani, India
    Genet Mol Res 6:284-91. 2007
    ..Further such studies are needed due to the extreme paucity of data on fish...
  92. ncbi Use of the argyrophilic nucleolar region method for cytologic and histologic examination of the lymph nodes in dogs
    P Vajdovich
    Department of Internal Medicine, Faculty of Veterinary Science, Szent Istvan University, Budapest, Hungary
    Vet Pathol 41:338-45. 2004
    ..Although AgNOR counts were different between cytologic and histologic samples, either sample type provided enough sensitivity to differentiate between high- and low-grade forms of lymphoma...
  93. ncbi Chromosomal polymorphism of mandarin vole, Microtus mandarinus (Rodentia)
    J X Wang
    Department of Biology, School of Life Sciences, Shandong University, Jinan, P R China
    Hereditas 138:47-53. 2003
    ..mandarinus karyotype evolution. The X displayed two different morphologies, which could be explained by prericentric inversion and a telocentric autosome translocation...
  94. ncbi Cytogenetic studies and karyotype nomenclature of three wild canid species: maned wolf (Chrysocyon brachyurus), bat-eared fox (Otocyon megalotis) and fennec fox (Fennecus zerda)
    A Pienkowska-Schelling
    Department of Animal Sciences, Swiss Federal Institute of Technology, Zurich, Switzerland
    Cytogenet Genome Res 121:25-34. 2008
    ..Our findings underline the need and justification for basic cytogenetic work in rare and exotic species...
  95. ncbi Argyrophilic nucleolar organizer regions (AgNORs) in interphases and metaphases of normal and neoplastic gill cells of Macoma balthica (Bivalvia: Tellinidae) from the Gulf of Gdansk, Baltic Sea
    K Smolarz
    Laboratory of Estuarine Ecology, Institute of Oceanography, University of Gdansk, Al Marszalka, J Pilsudskiego, 81 378 Gdynia, Poland
    Dis Aquat Organ 56:269-74. 2003
    ..The higher activity of AgNORs observed in abnormal cells confirmed the diagnosis of malignant neoplasia...
  96. ncbi Chromosomal polymorphisms due to heterochromatin growth and pericentric inversions in white-bellied rat, Niviventer confucianus, from China
    Jin Xing Wang
    School of Life Sciences, Shandong University, Jinan, P R China
    Hereditas 138:59-64. 2003
    ..The submetacentric chromosomes of Shaanxi population would be originated from the growth of heterochromatin of the subtelocentric chromosome of Shandong population...
  97. ncbi Chromosomal characteristics of ribosomal DNA in two extant species of North American mudminnows Umbra pygmaea and U. limi (Euteleostei: Umbridae)
    P Rab
    Laboratory of Fish Genetics, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Libechov, Czech Republic
    Cytogenet Genome Res 98:194-8. 2002
    ..The presence of additional rDNA sites is indicative of more complex rearrangements. The pericentromeric NOR phenotype of Umbra pygmaea is similar to that seen in U. krameri and in the distantly related genus Esox...
  98. ncbi Chromosomal studies on ten species of notothenioid fishes (Notothenioidei: Bathydraconidae, Channichthyidae, Nototheniidae)
    V Caputo
    Istituto di Biologia e Genetica, Universita Politecnica delle Marche, Via Brecce Bianche, 60100 Ancona, Italy
    Cytogenet Genome Res 98:285-90. 2002
    ..This could play an important role in favouring or hampering chromosome rearrangements...
  99. ncbi Karyotypic characterization of the bat species Molossus ater, M. molossus and Molossops planirostris (Chiroptera, Molossidae) using FISH and banding techniques
    Cleide Leite-Silva
    Departamento de Genética CCB, Universidade Federal de Pernambuco, Cidade Universitaria, Recife, PE, Brazil
    Hereditas 138:94-100. 2003
    ..The results obtained by FISH, compared with those by AgNO3 staining, indicated that all NORs in these species are transcriptionally active...
  100. ncbi Cytogenetic analysis of four species of the genus Alsodes (Anura: Leptodactylidae) with comments about the karyological evolution of the genus
    César C Cuevas
    Instituto de Zoologia, Universidad Austral de Chile, Valdivia, Chile
    Hereditas 138:138-47. 2003
    ..Transformation of euchromatin into heterochromatin and centric fissions and translocations are proposed as the main mechanisms that govern the chromosomal evolution of the frog genus Alsodes...
  101. ncbi [Metaphase chromosomes of human multiple myeloma cells of line U-266: karyotype and morpho-functional characteristics of nucleolar organizer regions]
    V I Turilova
    Institute of Cytology RAS, St Petersburg
    Tsitologiia 45:606-13. 2003
    ..a.s.). The average summarized AgNOR size was 7.19 +/- 0.03 u.a.s. Peculiarities of the NOR morpho-functional status in U-266 cells are discussed...

Research Grants8

  1. RNA PROCESSING AND RIBONUCLEOPROTEIN
    Thoru Pederson; Fiscal Year: 2001
    ..The same studies should provide information on sequences required for nuclear export. These two inter-related projects test the hypothesis that the nucleolus is a more pluri-functional organelle than previously thought. ..
  2. PERINUCLEOLAR COMPARTMENT AND CANCER
    Sui Huang; Fiscal Year: 2003
    ..The results of these experiments will provide an important foundation to address the significance of the PNC in malignant cells. ..
  3. The Perinucleolar Compartment as Breast Cancer Marker
    Sui Huang; Fiscal Year: 2005
    ..We expect the proposed studies will clarify whether the PNC, an easily detectable cellular structure, could improve the accuracy of breast cancer prognosis and prediction when used in combination with existing markers. ..
  4. RNA Transport Within the Nucleus
    Thoru Pederson; Fiscal Year: 2005
    ..Another aspect of the project will address the intranuclear traffic of these RNAs in relation to proteins known to be involved in nuclear import or RNA export, i.e. the Ran-GTPase and TAP. ..
  5. A Novel HTP Assay for Identification of Compounds that Reduce PNC Prevalence
    Sui Huang; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  6. TUMOR VACCINES FOR THE TREATMENT OF ORAL MELANOMA
    David Vail; Fiscal Year: 2002
    ..Furthermore, we expect to have a better understanding of the mechanism of action of genetically-modified ATCV. ..
  7. AUTOANTIGEN RNA HELICASE II/GU
    Benigno Valdez; Fiscal Year: 2003
    ..This study may also provide an impetus for understanding the pathological roles of RH-II/Gu on the elicitation of autoimmune responses. ..
  8. Characterization of p53-independent ARF pathway
    Jason Weber; Fiscal Year: 2007
    ..unreadable] [unreadable]..