cell division

Summary

Summary: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.

Top Publications

  1. ncbi Stem cells, cancer, and cancer stem cells
    T Reya
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Palo Alto, California 94305, USA
    Nature 414:105-11. 2001
  2. ncbi The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    Igor Vivanco
    Department of Medicine and Molecular Biology Institute, UCLA School of Medicine, 11 935 Factor Building, 10833 LeConte Avenue, Los Angeles, California 90095, USA
    Nat Rev Cancer 2:489-501. 2002
  3. ncbi FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
    Markus Welcker
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nat Rev Cancer 8:83-93. 2008
  4. ncbi Identification of a cancer stem cell in human brain tumors
    Sheila K Singh
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Cancer Res 63:5821-8. 2003
  5. ncbi Integrin signaling
    F G Giancotti
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 285:1028-32. 1999
  6. ncbi Lineage relationship and protective immunity of memory CD8 T cell subsets
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 4:225-34. 2003
  7. ncbi Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    D Bonnet
    Department of Genetics, Research Institute, Hospital for Sick Children, University of Toronto, Ontario, Canada
    Nat Med 3:730-7. 1997
  8. pmc Segregation of molecules at cell division reveals native protein localization
    Dirk Landgraf
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Methods 9:480-2. 2012
  9. ncbi Bacterial persistence as a phenotypic switch
    Nathalie Q Balaban
    Laboratory of Living Matter and Center for Studies in Physics and Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 305:1622-5. 2004
  10. ncbi Mitotic kinases as regulators of cell division and its checkpoints
    E A Nigg
    Max Planck Institute for Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Nat Rev Mol Cell Biol 2:21-32. 2001

Detail Information

Publications336 found, 100 shown here

  1. ncbi Stem cells, cancer, and cancer stem cells
    T Reya
    Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Palo Alto, California 94305, USA
    Nature 414:105-11. 2001
    ....
  2. ncbi The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    Igor Vivanco
    Department of Medicine and Molecular Biology Institute, UCLA School of Medicine, 11 935 Factor Building, 10833 LeConte Avenue, Los Angeles, California 90095, USA
    Nat Rev Cancer 2:489-501. 2002
  3. ncbi FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
    Markus Welcker
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109, USA
    Nat Rev Cancer 8:83-93. 2008
    ..This Review focuses on structural and functional aspects of FBW7 and its role in the development of cancer...
  4. ncbi Identification of a cancer stem cell in human brain tumors
    Sheila K Singh
    The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    Cancer Res 63:5821-8. 2003
    ..The identification of a BTSC provides a powerful tool to investigate the tumorigenic process in the central nervous system and to develop therapies targeted to the BTSC...
  5. ncbi Integrin signaling
    F G Giancotti
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Science 285:1028-32. 1999
    ..Many integrin signals converge on cell cycle regulation, directing cells to live or die, to proliferate, or to exit the cell cycle and differentiate...
  6. ncbi Lineage relationship and protective immunity of memory CD8 T cell subsets
    E John Wherry
    Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Immunol 4:225-34. 2003
    ..We propose that T(CM) and T(EM) do not necessarily represent distinct subsets, but are part of a continuum in a linear naive --> effector --> T(EM) --> T(CM) differentiation pathway...
  7. ncbi Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    D Bonnet
    Department of Genetics, Research Institute, Hospital for Sick Children, University of Toronto, Ontario, Canada
    Nat Med 3:730-7. 1997
    ..The SL-ICs were able to differentiate in vivo into leukemic blasts, indicating that the leukemic clone is organized as a hierarchy...
  8. pmc Segregation of molecules at cell division reveals native protein localization
    Dirk Landgraf
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Methods 9:480-2. 2012
    We introduce a nonintrusive method exploiting single-cell variability after cell division to validate protein localization...
  9. ncbi Bacterial persistence as a phenotypic switch
    Nathalie Q Balaban
    Laboratory of Living Matter and Center for Studies in Physics and Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 305:1622-5. 2004
    ..Inherent heterogeneity of bacterial populations may be important in adaptation to fluctuating environments and in the persistence of bacterial infections...
  10. ncbi Mitotic kinases as regulators of cell division and its checkpoints
    E A Nigg
    Max Planck Institute for Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Nat Rev Mol Cell Biol 2:21-32. 2001
    ..Here, I give an overview of the many mitotic kinases that regulate cell division and the fidelity of chromosome transmission.
  11. ncbi Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function
    Eric Lecuyer
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada
    Cell 131:174-87. 2007
    ..A searchable web resource documenting mRNA expression and localization dynamics has been established and will serve as an invaluable tool for dissecting localization mechanisms and for predicting gene functions and interactions...
  12. doi Mechanisms of asymmetric stem cell division
    Juergen A Knoblich
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, 1030 Vienna, Austria
    Cell 132:583-97. 2008
    ..To achieve this remarkable task, they can undergo an intrinsically asymmetric cell division whereby they segregate cell fate determinants into only one of the two daughter cells...
  13. ncbi Vascular niche for adult hippocampal neurogenesis
    T D Palmer
    Stanford University, Department of Neurosurgery, Palo Alto, California 94305, USA
    J Comp Neurol 425:479-94. 2000
    ..This environment may provide a novel interface where mesenchyme-derived cells and circulating factors influence plasticity in the adult central nervous system...
  14. ncbi Cellular motility driven by assembly and disassembly of actin filaments
    Thomas D Pollard
    Department of Cellular, Molecular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 112:453-65. 2003
    ..Profilin catalyzes the exchange of ADP for ATP, refilling the pool of ATP-actin monomers bound to profilin, ready for elongation...
  15. ncbi p53, the cellular gatekeeper for growth and division
    A J Levine
    Department of Molecular Biology, Lewis Thomas Laboratory, Princeton University, New Jersey 08544, USA
    Cell 88:323-31. 1997
  16. ncbi Pluripotency of mesenchymal stem cells derived from adult marrow
    Yuehua Jiang
    Stem Cell Institute, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Nature 418:41-9. 2002
    ..As MAPCs proliferate extensively without obvious senescence or loss of differentiation potential, they may be an ideal cell source for therapy of inherited or degenerative diseases...
  17. ncbi Out of Eden: stem cells and their niches
    F M Watt
    Keratinocyte Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Science 287:1427-30. 2000
    ..Certain aspects of the stem cell microenvironment, or niche, are conserved between tissues, and this can be exploited in the application of stem cells to tissue replacement therapy...
  18. ncbi AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1
    R H Medema
    Department of Hematology, University Medical Center, Utrecht, The Netherlands
    Nature 404:782-7. 2000
    ..We conclude that AFX-like proteins are involved in cell-cycle regulation and that inactivation of these proteins is an important step in oncogenic transformation...
  19. pmc Dual function of Cyk2, a cdc15/PSTPIP family protein, in regulating actomyosin ring dynamics and septin distribution
    J Lippincott
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 143:1947-60. 1998
    ..Overexpression of Cyk2p also blocks cytokinesis, most likely due to a loss of the septins from the bud neck, indicating that Cyk2p may also play a role in regulating the localization of the septins...
  20. ncbi Mammalian neural stem cells
    F H Gage
    The Salk Institute, Laboratory of Genetics, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 287:1433-8. 2000
    ..Before the full potential of neural stem cells can be realized, we need to learn what controls their proliferation, as well as the various pathways of differentiation available to their daughter cells...
  21. ncbi Systematic identification of pathways that couple cell growth and division in yeast
    Paul Jorgensen
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Science 297:395-400. 2002
    ..Cell growth and division appear to be coupled by multiple conserved mechanisms...
  22. doi Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy
    Philipp J Keller
    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Science 322:1065-9. 2008
    ..Our analysis of global cell division patterns reveals a maternally defined initial morphodynamic symmetry break, which identifies the embryonic ..
  23. ncbi Hypoxia--a key regulatory factor in tumour growth
    Adrian L Harris
    Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Nat Rev Cancer 2:38-47. 2002
    ..Many elements of the hypoxia-response pathway are therefore good candidates for therapeutic targeting...
  24. doi Aurora B-mediated abscission checkpoint protects against tetraploidization
    Patrick Steigemann
    Institute of Biochemistry, Swiss Institute of Technology Zurich, ETHZ, Zurich, Switzerland
    Cell 136:473-84. 2009
    ..Here, we report a cell division control mechanism that prevents tetraploidization in human cells with perturbed chromosome segregation...
  25. doi Bacterial cell division: assembly, maintenance and disassembly of the Z ring
    David W Adams
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Nat Rev Microbiol 7:642-53. 2009
    Bacterial cell division is orchestrated by a tubulin homologue, FtsZ, which polymerizes to form a ring-like structure that is both a scaffold for the assembly of the bacterial cytokinetic machinery and, at least in part, a source of the ..
  26. ncbi Hematopoietic stem cell quiescence maintained by p21cip1/waf1
    T Cheng
    Experimental Hematology, AIDS Research Center, Massachusetts General Hospital Cancer Center, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Science 287:1804-8. 2000
    ..Under conditions of stress, restricted cell cycling is crucial to prevent premature stem cell depletion and hematopoietic death...
  27. ncbi A role for Wnt signalling in self-renewal of haematopoietic stem cells
    Tannishtha Reya
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 423:409-14. 2003
    ..We conclude that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and provide insight into a potential molecular hierarchy of regulation of HSC development...
  28. ncbi Control mechanism of the circadian clock for timing of cell division in vivo
    Takuya Matsuo
    Division of Molecular Brain Science, Department of Brain Sciences, Kobe University Graduate School of Medicine, Chuo Ku, Kobe 650 0017, Japan
    Science 302:255-9. 2003
    b>Cell division in many mammalian tissues is associated with specific times of day, but just how the circadian clock controls this timing has not been clear...
  29. pmc Asymmetric cell divisions promote stratification and differentiation of mammalian skin
    Terry Lechler
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10021, USA
    Nature 437:275-80. 2005
    ..We further demonstrate that integrins and cadherins are essential for the apical localization of atypical protein kinase C, the Par3-LGN-Inscuteable complex and NuMA-dynactin to align the spindle...
  30. ncbi The extracellular matrix guides the orientation of the cell division axis
    Manuel Thery
    Biologie du cycle cellulaire et de la motilité, UMR144, CNRS, Institut Curie, 26 rue d Ulm 75248 Paris Cedex 05, France
    Nat Cell Biol 7:947-53. 2005
    The cell division axis determines the future positions of daughter cells and is therefore critical for cell fate...
  31. ncbi Logic of the yeast metabolic cycle: temporal compartmentalization of cellular processes
    Benjamin P Tu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, L3 124, Dallas, TX 75390, USA
    Science 310:1152-8. 2005
    ..Essential cellular and metabolic events occur in synchrony with the metabolic cycle, demonstrating that key processes in a simple eukaryotic cell are compartmentalized in time...
  32. ncbi The PLETHORA genes mediate patterning of the Arabidopsis root stem cell niche
    Mitsuhiro Aida
    Department of Molecular Cell Biology, Utrecht University, Padualaan 8, 3514CH Utrecht, The Netherlands
    Cell 119:109-20. 2004
    ..Thus, the PLT genes are key effectors for establishment of the stem cell niche during embryonic pattern formation...
  33. doi Spindle orientation during asymmetric cell division
    Karsten H Siller
    Institute of Molecular Biology, Institute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, 97403, USA
    Nat Cell Biol 11:365-74. 2009
    ....
  34. ncbi MipZ, a spatial regulator coordinating chromosome segregation with cell division in Caulobacter
    Martin Thanbichler
    Department of Developmental Biology, Stanford University School of Medicine, Beckman Center B300, 279 Campus Drive, Stanford, CA 94305, USA
    Cell 126:147-62. 2006
    ..The cellular localization of MipZ thus serves the dual function of positioning the FtsZ ring and delaying formation of the cell division apparatus until chromosome segregation has initiated.
  35. pmc Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism
    Matthew L Steinhauser
    Department of Medicine, Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nature 481:516-9. 2012
    ..We test the 'immortal strand hypothesis', which predicts that during asymmetric stem cell division chromosomes containing older template DNA are segregated to the daughter destined to remain a stem cell, thus ..
  36. ncbi Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
    C Tournier
    Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 288:870-4. 2000
    ..These data indicate that mitochondria are influenced by proapoptotic signal transduction through the JNK pathway...
  37. ncbi Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
    K S Schluns
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
    Nat Immunol 1:426-32. 2000
    ..Homeostatic proliferation of memory cells was also partially dependent on IL-7. These results point to IL-7 as a pivotal cytokine in T cell homeostasis...
  38. ncbi TSC2 mediates cellular energy response to control cell growth and survival
    Ken Inoki
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Cell 115:577-90. 2003
    ..These observations demonstrate a model where TSC2 functions as a key player in regulation of the common mTOR pathway of protein synthesis, cell growth, and viability in response to cellular energy levels...
  39. doi A genetic framework for the control of cell division and differentiation in the root meristem
    Raffaele Dello Ioio
    Dipartimento di Genetica e Biologia Molecolare, Laboratorio di Genomica e Proteomica Funzionale dei Sistemi Modello FGPL, Università La Sapienza Piazzale Aldo Moro 5, 00185 Rome, Italy
    Science 322:1380-4. 2008
    ..Conversely, auxin mediates degradation of the SHY2 protein, sustaining PIN activities and cell division. Thus, the cell differentiation and division balance necessary for controlling root meristem size and root ..
  40. ncbi Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    David M Berman
    Department of Molecular Biology and Genetics and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 425:846-51. 2003
    ..Our results identify a group of common lethal malignancies in which Hh pathway activity, essential for tumour growth, is activated not by mutation but by ligand expression...
  41. ncbi Bone marrow as a potential source of hepatic oval cells
    B E Petersen
    Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Science 284:1168-70. 1999
    ..From these cells, a proportion of the regenerated hepatic cells were shown to be donor-derived. Thus, a stem cell associated with the bone marrow has epithelial cell lineage capability...
  42. ncbi Asymmetric inheritance of oxidatively damaged proteins during cytokinesis
    Hugo Aguilaniu
    Department of Cell and Molecular Biology Microbiology, Goteborg University, Goteborg, Sweden
    Science 299:1751-3. 2003
    ..These findings suggest that a genetically determined, Sir2p-dependent asymmetric inheritance of oxidatively damaged proteins may contribute to free-radical defense and the fitness of newborn cells...
  43. pmc Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal
    Adan Aguirre
    Center for Neuroscience Research, Children s National Medical Center, Washington, District of Columbia 20010, USA
    Nature 467:323-7. 2010
    ..Our findings define a novel interaction between EGFR and Notch pathways in the adult SVZ, and thus provide a mechanism for NSC and NPC pool maintenance...
  44. ncbi TRF2 protects human telomeres from end-to-end fusions
    B van Steensel
    The Rockefeller University, New York, New York 10021, USA
    Cell 92:401-13. 1998
    ..The results raise the possibility that chromosome end fusions and senescence in primary human cells may be caused by loss by TRF2 from shortened telomeres...
  45. ncbi Pax7 is required for the specification of myogenic satellite cells
    P Seale
    Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Cell 102:777-86. 2000
    ..Together these studies suggest that induction of Pax7 in muscle-derived stem cells induces satellite cell specification by restricting alternate developmental programs...
  46. doi Mitotic spindle orientation in asymmetric and symmetric cell divisions during animal development
    Xavier Morin
    Institut de Biologie de l Ecole Normale Supérieure, 46 rue d Ulm, Paris, France
    Dev Cell 21:102-19. 2011
    ..regulating the orientation of the axis of division and cell fate choices in classical models of asymmetric cell division. We then discuss the mechanisms of mitotic spindle orientation in symmetric cell divisions and its possible ..
  47. ncbi How microRNAs control cell division, differentiation and death
    Eric A Miska
    Wellcome Trust Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, CB2 1QN, UK
    Curr Opin Genet Dev 15:563-8. 2005
    ..Functional studies in zebrafish and mice point toward important roles for microRNAs during morphogenesis and organogenesis. Finally, microRNAs might regulate viral infection and human cancer...
  48. ncbi WNT signals are required for the initiation of hair follicle development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 2:643-53. 2002
    ..This phenotype indicates that activation of WNT signaling in the skin precedes, and is required for, localized expression of regulatory genes and initiation of hair follicle placode formation...
  49. pmc Asymmetric cell divisions promote Notch-dependent epidermal differentiation
    Scott E Williams
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York 10065, USA
    Nature 470:353-8. 2011
    ....
  50. ncbi Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
    Gary L Johnson
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Science 298:1911-2. 2002
    ..The extracellular signal-regulated kinases (ERKs) function in the control of cell division, and inhibitors of these enzymes are being explored as anticancer agents...
  51. ncbi An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
    W Brogiolo
    Zoologisches Institut, Universitat Zurich, Winterthurerstrasse 190, CH 8057, Zurich, Switzerland
    Curr Biol 11:213-21. 2001
    ....
  52. pmc Inhibition of T cell proliferation by macrophage tryptophan catabolism
    D H Munn
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia 30912, USA
    J Exp Med 189:1363-72. 1999
    ..We speculate that expression of IDO by certain antigen presenting cells in vivo allows them to suppress unwanted T cell responses...
  53. ncbi Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
    Alexandra E Butler
    Division of Endocrinology and Diabetes, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Diabetes 52:102-10. 2003
    ....
  54. ncbi Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    O Tetsu
    University of California, San Francisco, School of Medicine, Cancer Research Institute, 94143 0128, USA
    Nature 398:422-6. 1999
    ..Abnormal levels of beta-catenin may therefore contribute to neoplastic transformation by causing accumulation of cyclin D1...
  55. ncbi Geminin, an inhibitor of DNA replication, is degraded during mitosis
    T J McGarry
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 93:1043-53. 1998
    ..We propose that geminin inhibits DNA replication during S, G2, and M phases and that geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle...
  56. pmc Non-genetic heterogeneity from stochastic partitioning at cell division
    Dann Huh
    Department of Systems Biology, Harvard University, Boston, Massachusetts, USA
    Nat Genet 43:95-100. 2011
    ..But fluctuations also arise during cell division when molecules are partitioned stochastically between the two daughters...
  57. pmc Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex
    Ronald S Bultje
    Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Neuron 63:189-202. 2009
    Asymmetric cell division of radial glial progenitors produces neurons while allowing self-renewal; however, little is known about the mechanism that generates asymmetry in daughter cell fate specification...
  58. ncbi Regulation of cerebral cortical size by control of cell cycle exit in neural precursors
    Anjen Chenn
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Science 297:365-9. 2002
    ....
  59. ncbi The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis
    Irina M Conboy
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Dev Cell 3:397-409. 2002
    ..progenitor cells, Numb was localized asymmetrically in actively dividing cells, suggesting an asymmetric cell division and divergent cell fates of daughter cells...
  60. pmc Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans
    Juris J Meier
    Larry Hillblom Islet Research Center, UCLA David Geffen School of Medicine, Los Angeles, California 90095 7073, USA
    Diabetes 57:1584-94. 2008
    ..We also sought to establish if there is a secondary growth in beta-cell mass coincident with the accelerated somatic growth in adolescence...
  61. ncbi Asymmetric production of surface-dividing and non-surface-dividing cortical progenitor cells
    Takaki Miyata
    Laboratory for Cell Culture Development, Brain Science Institute, RIKEN, Saitama 351 0198, Japan
    Development 131:3133-45. 2004
    ..The asymmetric P/P division may therefore contribute to efficient neuron/progenitor segregation required for CP initiation through cell cycle-dependent and lineage-restricted expression of Ngn2...
  62. ncbi Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle
    D Yaffe
    Nature 270:725-7. 1977
  63. pmc A unique cell division machinery in the Archaea
    Ann Christin Lindås
    Department of Molecular Evolution, Evolutionary Biology Center, Uppsala University, Norbyvagen 18C, SE 752 36, Uppsala, Sweden
    Proc Natl Acad Sci U S A 105:18942-6. 2008
    In contrast to the cell division machineries of bacteria, euryarchaea, and eukaryotes, no division components have been identified in the second main archaeal phylum, Crenarchaeota...
  64. ncbi Asymmetric and symmetric stem-cell divisions in development and cancer
    Sean J Morrison
    Howard Hughes Medical Institute and Life Sciences Institute, Department of Internal Medicine, and Center for Stem Cell Biology, University of Michigan, Ann Arbor, Michigan 48109 2216, USA
    Nature 441:1068-74. 2006
    Much has been made of the idea that asymmetric cell division is a defining characteristic of stem cells that enables them to simultaneously perpetuate themselves (self-renew) and generate differentiated progeny...
  65. ncbi The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer
    Katrien Vermeulen
    Faculty of Medicine, Laboratory of Experimental Hematology, University of Antwerp, Antwerp University Hospital, Edegem, Belgium
    Cell Prolif 36:131-49. 2003
    The cell cycle is controlled by numerous mechanisms ensuring correct cell division. This review will focus on these mechanisms, i.e. regulation of cyclin-dependent kinases (CDK) by cyclins, CDK inhibitors and phosphorylating events...
  66. pmc Acute and fractionated irradiation differentially modulate glioma stem cell division kinetics
    Xuefeng Gao
    Center of Cancer Systems Biology, Steward Research Institute, St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    Cancer Res 73:1481-90. 2013
    ..We hypothesize a constitutive activation of stem cell division kinetics signaling pathways during fractionated treatment, which contributes to the frequently observed ..
  67. pmc Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes
    Beate Neumann
    MitoCheck Project Group, European Molecular Biology Laboratory EMBL, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Nature 464:721-7. 2010
    ..which allowed us to identify hundreds of human genes involved in diverse biological functions including cell division, migration and survival...
  68. pmc Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
    Simona Parrinello
    Life Sciences Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720, USA
    Nat Cell Biol 5:741-7. 2003
    ..Our results identify oxygen sensitivity as a critical difference between mouse and human cells, explaining their proliferative differences in culture, and possibly their different rates of cancer and ageing...
  69. pmc Asymmetric cell division: recent developments and their implications for tumour biology
    Juergen A Knoblich
    Institute of Molecular Biotechnology of Austrian Academy of Science, Doktor Bohr Gasse 3, 1030 Vienna, Austria
    Nat Rev Mol Cell Biol 11:849-60. 2010
    ..The relevance of asymmetric cell division for stem cell biology has added a new dimension to the field, and exciting connections between asymmetric cell ..
  70. pmc Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells
    Matthew A Williams
    Howard Hughes Medical Institute and Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nature 441:890-3. 2006
    ..These results have important implications for the development of vaccination or immunotherapeutic strategies aimed at boosting memory T-cell function...
  71. ncbi Asymmetric T lymphocyte division in the initiation of adaptive immune responses
    John T Chang
    Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 315:1687-91. 2007
    ..exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell division. Asymmetric segregation of determinants appears to be coordinated by prolonged interaction between the T cell ..
  72. doi Cell division control by the Chromosomal Passenger Complex
    Maike S van der Waal
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht, The Netherlands
    Exp Cell Res 318:1407-20. 2012
    ..This review describes recent insights on how the CPC is capable of conducting its various functions in the dividing cell to ensure chromosomal stability...
  73. pmc Cell growth and size homeostasis in proliferating animal cells
    Amit Tzur
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 325:167-71. 2009
    ..The probability of cell division varies independently with cell size and cell age...
  74. doi Bacterial peptidoglycan (murein) hydrolases
    Waldemar Vollmer
    Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    FEMS Microbiol Rev 32:259-86. 2008
    ..of cell wall growth, the turnover of peptidoglycan during growth, the separation of daughter cells during cell division and autolysis...
  75. pmc Altered modes of stem cell division drive adaptive intestinal growth
    Lucy Erin O'Brien
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell 147:603-14. 2011
    ..Thus, tissue renewal programs are not committed to maintain cellular equilibrium; stem cells can remodel organs in response to physiological triggers...
  76. ncbi Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    C Deng
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 82:675-84. 1995
    ..These results establish the role of p21CIP1/WAF1 in the G1 checkpoint, but suggest that the anti-apoptotic and the anti-oncogenic effects of p53 are more complex...
  77. pmc A role for the ESCRT system in cell division in archaea
    Rachel Y Samson
    Medical Research Council MRC Cancer Cell Unit, Hills Road, Cambridge CB2 0XZ, UK
    Science 322:1710-3. 2008
    ..Furthermore, these proteins specifically localized to the mid-cell during cell division. Overexpression of a catalytically inactive mutant Vps4 in Sulfolobus resulted in the accumulation of enlarged ..
  78. pmc Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    B St-Jacques
    Harvard University, Department of Molecular and Cellular Biology, Cambridge, Massachusetts 02138 USA
    Genes Dev 13:2072-86. 1999
    ..Together, the results suggest a model in which Ihh coordinates diverse aspects of skeletal morphogenesis through PTHrP-dependent and independent processes...
  79. pmc Distinct behaviors of neural stem and progenitor cells underlie cortical neurogenesis
    Stephen C Noctor
    Department of Neurology, University of California, San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 508:28-44. 2008
    ..We propose a model for predicting daughter cell fate that considers precursor cell type, stage of development, and the planar segregation of fate determinants...
  80. ncbi Stomatal patterning and differentiation by synergistic interactions of receptor kinases
    Elena D Shpak
    Department of Biology, University of Washington, Seattle, WA 98195, USA
    Science 309:290-3. 2005
    ..Our findings suggest that the negative regulation of ER-family RLKs by TMM, which is an LRR receptor-like protein, is critical for proper stomatal differentiation...
  81. ncbi Purification and characterization of mouse hematopoietic stem cells
    G J Spangrude
    Department of Pathology, Stanford University School of Medicine, CA 94305
    Science 241:58-62. 1988
    ..Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors...
  82. ncbi Type 2 diabetes-a matter of beta-cell life and death?
    Christopher J Rhodes
    Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA
    Science 307:380-4. 2005
    ..Thus, the IRS-2 pathway appears to be a crucial participant in the tenuous balance between effective pancreatic beta-cell mass and insulin resistance...
  83. doi Single-cell dynamics of the chromosome replication and cell division cycles in mycobacteria
    Isabella Santi
    School of Life Sciences, Swiss Federal Institute of Technology in Lausanne EPFL, Lausanne 1015, Switzerland
    Nat Commun 4:2470. 2013
    During the bacterial cell cycle, chromosome replication and cell division must be coordinated with overall cell growth in order to maintain the correct ploidy and cell size...
  84. ncbi FtsZ ring structure associated with division in Escherichia coli
    E F Bi
    Department of Microbiology, University of Kansas Medical Center, Kansas City 66103
    Nature 354:161-4. 1991
    Genes for cell division have been identified in Escherichia coli by the isolation of conditional lethal mutations that block cell division, but do not affect DNA replication or segregation...
  85. ncbi Atm-deficient mice: a paradigm of ataxia telangiectasia
    C Barlow
    Laboratory of Genetic Disease Research, National Center for Human Genome Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cell 86:159-71. 1996
    ..Atm-disrupted mice recapitulate the ataxia telangiectasia phenotype in humans, providing a mammalian model in which to study the pathophysiology of this pleiotropic disorder...
  86. doi Progesterone induces adult mammary stem cell expansion
    Purna A Joshi
    Ontario Cancer Institute, Department of Medical Biophysics and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 2M9, Ontario, Canada
    Nature 465:803-7. 2010
    ..Our findings uncover a dynamic role for progesterone in activating adult MaSCs within the mammary stem cell niche during the reproductive cycle, where MaSCs are putative targets for cell transformation events leading to breast cancer...
  87. doi The physiology of bacterial cell division
    Alexander J F Egan
    Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle upon Tyne, UK
    Ann N Y Acad Sci 1277:8-28. 2013
    Bacterial cell division is facilitated by the divisome, a dynamic multiprotein assembly localizing at mid-cell to synthesize the stress-bearing peptidoglycan and to constrict all cell envelope layers...
  88. ncbi Rho GTPases in cell biology
    Sandrine Etienne-Manneville
    MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, Cancer Research UK Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK
    Nature 420:629-35. 2002
    ..With spatial and temporal activation of multiple switches factored in, it is not surprising to find Rho GTPases having such a prominent role in eukaryotic cell biology...
  89. doi Intestinal stem cell replacement follows a pattern of neutral drift
    Carlos Lopez-Garcia
    Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Science 330:822-5. 2010
    ..Combined with long-term clonal fate data, we show that the rate of stem cell replacement is comparable to the cell division rate, implying that neutral drift and symmetrical cell divisions are central to stem cell homeostasis.
  90. pmc Cellular responses to auxin: division versus expansion
    Catherine Perrot-Rechenmann
    Institut des Sciences du Vegetal, UPR2355 CNRS, 1 Avenue de la Terrasse, 91198 Gif sur Yvette, Cedex, France
    Cold Spring Harb Perspect Biol 2:a001446. 2010
    ..Many aspects of these processes depend on the multiple controls exerted by auxin on cell division and cell expansion...
  91. ncbi Radiation-induced cell cycle arrest compromised by p21 deficiency
    J Brugarolas
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 377:552-7. 1995
    ..However, p21-/- mouse embryo fibroblasts are impaired in their ability to undergo G1 arrest following DNA damage...
  92. pmc Positive control of cell division: FtsZ is recruited by SsgB during sporulation of Streptomyces
    Joost Willemse
    Molecular Biotechnology, Gorlaeus Laboratories, Leiden University, Leiden 2300RA, The Netherlands
    Genes Dev 25:89-99. 2011
    In bacteria that divide by binary fission, cell division starts with the polymerization of the tubulin homolog FtsZ at mid-cell to form a cell division scaffold (the Z ring), followed by recruitment of the other divisome components...
  93. ncbi c-Myc regulates mammalian body size by controlling cell number but not cell size
    A Trumpp
    Swiss Institute for Experimental Cancer Research ISREC, Ch des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 414:768-73. 2001
    ..We propose that in mammals c-Myc controls the decision to divide or not to divide and thereby functions as a crucial mediator of signals that determine organ and body size...
  94. ncbi Aberrant rel/nfkb genes and activity in human cancer
    B Rayet
    Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, NJ 08854 5638, USA
    Oncogene 18:6938-47. 1999
    ..This review focuses on the status of the rel, nfkb and ikb genes and their activity in human tumors and their association with the onset or progression of malignancies...
  95. pmc YeeV is an Escherichia coli toxin that inhibits cell division by targeting the cytoskeleton proteins, FtsZ and MreB
    Qian Tan
    Department of Biochemistry, Center for Advanced Biotechnology and Medicine, Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA
    Mol Microbiol 79:109-18. 2011
    ..Here we show that YeeV toxin inhibits cell division, leads to a change in morphology and lysis of Escherichia coli cells...
  96. ncbi Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
    Keisuke Ito
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 431:997-1002. 2004
    ..These results show that the self-renewal capacity of HSCs depends on ATM-mediated inhibition of oxidative stress...
  97. pmc Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    Ken Inoki
    Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Genes Dev 17:1829-34. 2003
    ..Our data demonstrate that Rheb acts downstream of TSC1/TSC2 and upstream of mTOR to regulate cell growth...
  98. ncbi Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS
    C J Gimeno
    Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge 02142
    Cell 68:1077-90. 1992
    ..cerevisiae strains undergo a dimorphic transition that involves changes in cell shape and the pattern of cell division and results in invasive filamentous growth in response to starvation for nitrogen...
  99. ncbi Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells
    Joerg Betschinger
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Cell 124:1241-53. 2006
    ..Similar defects are seen in lethal giant larvae (lgl) mutants where Brat and Prospero are not asymmetric. We have identified a molecular mechanism that may control self-renewal and prevent tumor formation in other stem cells as well...
  100. pmc Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer
    Ralph A Neumüller
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, 1030 Vienna, Austria
    Genes Dev 23:2675-99. 2009
    b>Cell division is commonly thought to involve the equal distribution of cellular components into the two daughter cells...
  101. doi The Aurora kinase family in cell division and cancer
    Gerben Vader
    Laboratory of Experimental Oncology, Department of Medical Oncology, University Medical Center Utrecht, Stratenum 2 125, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Biochim Biophys Acta 1786:60-72. 2008
    ..family (consisting of Aurora-A, -B and -C) is an important group of enzymes that controls several aspects of cell division in mammalian cells...

Research Grants71

  1. The Role of Cks Proteins in Mammalian Meiosis
    Charles H Spruck; Fiscal Year: 2010
    ..a hetero-trimer known as maturation- promoting factor (MPF) that regulates M phase in both mitotic and meiotic cell division cycles...
  2. Weight Loss &Exercise Effects on Telomere Length in Postmenopausal Women
    ANNE M MCTIERNAN; Fiscal Year: 2012
    ..Progressive telomere shortening of somatic cells with successive cell division is a hallmark of cellular aging, with loss of ~ 50-100 base pairs per cell division...
  3. Environmental Risk Factors for Copy Number Variation in Human Chromosomes
    THOMAS EDWARD WILSON; Fiscal Year: 2010
    ....
  4. 4th ASM Conference on Prokaryotic Cell Biology and Development
    Susan S Golden; Fiscal Year: 2012
    ..cell biology have led to fundamental insights in our understanding of essential cell structures including the cell division apparatus, the cytoskeleton, the cell wall, and structures involved in bacterial motility...
  5. Bioflavonoid Effects on EGF Signaling and Cell Cycle Pathways in Prostate Cancer
    BARRY MATTHEW MARKAVERICH; Fiscal Year: 2013
    ..MeHPLA, in the control of the activity of the EGF Signaling Pathway genes and normal and malignant prostate cell division. These studies may lead to the development of new drugs and/or dietary components for use in cancer prevention ..
  6. Characterization of new toxins (YmgD and YdfD) from E.coli, targeting cell wall
    Hisako Masuda; Fiscal Year: 2012
    ..Known toxins inhibit a wide range of cellular functions including DNA, mRNA, 30S and 50S ribosome subunits and cell division (17, 30, 37, 38). The exact role of these toxins on bacterial physiology is not yet clearly understood...
  7. Diverse Roles for RIC8 During G Protein Signaling in Fungi
    Katherine A Borkovich; Fiscal Year: 2012
    ..RIC8 is required for asymmetric cell division in both Caenorhabditis elegans and Drosophila...
  8. Identifying all Meckel-like ciliopathy genes by established total exome capture a
    Friedhelm Hildebrandt; Fiscal Year: 2010
    ..Centrosomal proteins regulate cell polarity and oriented cell division and participate in the mitotic spindle...
  9. Analysis of the role of the VRK1 protein kinase in mammalian fertility
    Paula Traktman; Fiscal Year: 2011
    ..is one of the major mechanisms used by eukaryotic cells to ensure that the phases of mitotic and meiotic cell division occur in the correct sequence and only when intracellular and extracellular conditions are favorable...
  10. DNA Damage Checkpoint and Cancer
    Toru Ouchi; Fiscal Year: 2012
    ..Cellular DNA must be accurately replicated and transmitted to each daughter cell during cell division. In response to various forms of genotoxic stress, cells activate complex protein kinase signaling pathways, ..
  11. Cell Cycle Regulation and Adult T Cell Leukemia
    Chou Zen Giam; Fiscal Year: 2013
    ..This project will elucidate the mechanism by which HTLV-1 infection affects the progression of cell division cycle and how these changes impact on the development of leukemia...
  12. Regulation of PTHrP in Squamous Cell Carcinoma by the EGF Receptor
    GWENDOLEN LORCH; Fiscal Year: 2010
    ..PTHrP has an important role in cancer and normal biology since it regulates cell division, differentiation, and apoptosis in addition to its function as a paracrine and endocrine hormone...
  13. IRON REGULATION OF GENE EXPRESSION
    ELIZABETH ANN LEIBOLD; Fiscal Year: 2013
    ..The nutritional requirement for iron is due to its role such essential cellular processes as cell division and energy production...
  14. Integrating stress MAP kinase signaling with DNA replication origin licensing
    Jeanette Gowen Cook; Fiscal Year: 2013
    ..Origin licensing is the earliest step in DNA replication, and failure to coordinate origin licensing with the cell division cycle leads to under-replicated or re- replicated chromosomal regions which are sources of cell death and ..
  15. Persisting Grand Mal and Myoclonic Seizures in JME including Veterans
    Antonio V Delgado-Escueta; Fiscal Year: 2013
    ..we provide more proof that JME is due to mutations in developmental genes, like Myoclonin1/EFHC1, involved in cell division, apoptosis, neuroblast migration, and synapse and dendrite growth...
  16. Functional study of C53 protein as a novel regulator of checkpoint kinases
    Honglin Li; Fiscal Year: 2012
    ..checkpoint regulates mitotic entry and activation of cyclin- dependent kinase 1 (Cdk1), a driving force for cell division. DNA damage usually evokes such checkpoints through activating a network of molecules including protein ..
  17. The Mechanism of Cryptorchidism in LH Receptor Knockout Animals
    Zhenmin Lei; Fiscal Year: 2012
    ..cell proliferation and differentiation analyses demonstrated the defect was due to a reduction in mesenchymal cell division and differentiation into cremaster muscle cells during the second stage of testis descent...
  18. Regulation of Odorant Receptor Gene Expression
    Paul Feinstein; Fiscal Year: 2013
    ..This epithelium is under continuous cell division by a basal stem cell population that produces immature olfactory neurons, which then become mature olfactory ..
  19. Effect of Neonatal Hyperoxia on Alveolar Development and Infection
    MICHAEL A O'REILLY; Fiscal Year: 2012
    ..Type II cells that selectively expresses genes that destroy RNA viruses and bacteria, and control asymmetric cell division of stem/progenitor cells...
  20. Chromosomal Control of Segregation of C. Elegans
    Abby F Dernburg; Fiscal Year: 2013
    ..This special cell division process gives rise to haploid gametes such as sperm, eggs, and pollen, which contain one complete set of ..
  21. Fnip1 Function in Lymphocyte Development, Activation and Metabolism
    Brian M Iritani; Fiscal Year: 2013
    ..glycolysis, which generates bio-precursors (such as lipids, amino acids, and nucleotides) required to fuel cell division. An understanding of the factors that control this metabolic switch (termed "Warburg effect") is highly ..
  22. Evaluation of novel FoxM1 inhibitors against liver cancer
    Andrei L Gartel; Fiscal Year: 2012
    ..drugs that target the underlying molecular events of HCC growth and interfere with HCC development by blocking cell division and selectively inducing tumor cell apoptosis...
  23. The Role of the Nuclear Lamina in Chromatin Organization and Gene Expression in N
    Marcos Estecio; Fiscal Year: 2012
    ..This structure has activity in key cellular functions, such as DNA replication, cell division and apoptosis...
  24. SIGNALING THROUGH RHO GTP/GDP EXCHANGE FACTORS
    Philip B Wedegaertner; Fiscal Year: 2013
    ..cell adhesion, cell migration, cell proliferation, neurite extension and retraction, gene expression and cell division. A sub-family of three RhoGEFs, termed regulator of G protein signaling domain-containing RhoGEFs (RGS-RhoGEFs)..
  25. CYCLE REGULATION IN THE SYMBIONT SINORHIZOBIUM MELILOTI
    KATHERINE ELISABETH GIBSON; Fiscal Year: 2011
    ..meliloti cell cycle progression and asymmetric cell division. Preliminary data from my lab demonstrates that disruption of each HK gene produces a cell cycle defect that ..
  26. AKT Signaling and Oxidative Stress Regulation of Erythropoiesis
    Saghi Ghaffari; Fiscal Year: 2013
    A tight coordination of erythroid cell division and maturation is required for daily production of erythroid cells and for immediate response to clinical conditions in which stress erythropoiesis is in demand...
  27. Mechanisms of arsenic-induced chromosomal instability and carcinogenesis
    Wei Dai; Fiscal Year: 2013
    ..High fidelity DNA replication and faithful distribution of the chromosomal complement to daughter cells during cell division are of paramount importance to the maintenance of chromosomal stability...
  28. Molecular Analysis of Pericentric Sister Chromatid Cohesion
    PAUL CONNOR MEGEE; Fiscal Year: 2013
    ..HEALTH RELEVANCE: Chromosomes must be accurately duplicated and segregated to daughter cells during each cell division, and errors in these events can lead to cancer or genetic disease, such as Down syndrome...
  29. Eukaryotic-type STK/STP-mediated modulation of enterococcal pathogenesis
    Vijay Pancholi; Fiscal Year: 2010
    ..The impact of the deletion of this gene on bacterial growth, morphology, cell division, ability to adhere to HepG2 cells, and formation of biofilms on abiotic surfaces will then be determined using ..
  30. The Forkhead Transcription Factor, FOXO1, and its Role in Pituitary Gland Develop
    BUFFY SUE ELLSWORTH; Fiscal Year: 2010
    ..The pattern of FOXO1 localization in the pituitary gland during development suggests a role for inhibiting cell division and regulating cell differentiation...
  31. The role of the orphan receptor tyrosine kinase Ros1 in vascular disease
    ZIAD ANWAR ALI; Fiscal Year: 2011
    ..at the time of stenting has directed us to a receptor without a known activator, Ros1, which is involved in cell division, growth, movement and death;processes all involved in atherosclerosis...
  32. ANALYSIS OF MEIOTIC CHROMOSOME SYNAPSIS IN YEAST
    Nancy M Hollingsworth; Fiscal Year: 2013
    ..This two-fold reduction in chromosome number is carried out by a specialized, evolutionarily conserved, cell division called meiosis...
  33. Defining the telomerase holoenzyme in progenitor cells with aging
    Steven E Artandi; Fiscal Year: 2013
    ..In settings of insufficient telomerase, including in aging human tissues, telomeres shorten with cell division. Telomerase subunits are mutated in certain human genetic diseases, such as dyskeratosis congenita, in which ..
  34. CSHL Eukaryotic DNA Replication Conference
    David J Stewart; Fiscal Year: 2013
    ..rapid growth in our understanding of the eukaryotic DNA replication process and how it is integrated into the cell division cycle...
  35. The role of the nucleoporin Nup98 in gene regulation
    Martin W Hetzer; Fiscal Year: 2013
    ..These approaches have the potential to reveal the gene regulatory role of mammalian Nup98 and provide insight into its leukemia-causing potential. ..
  36. The Effects of Ethanol on Microtubules during Mouse Pre-implantation Development
    Yixian Zheng; Fiscal Year: 2012
    ..regulated to ensure proper execution of intracellular organization, protein trafficking, cell migration, and cell division. Acetylation of 1-tubulin at its lysine-40 residue has been shown to affect microtubule assembly dynamics and ..
  37. 2011 EUKARYOTIC DNA REPLICATION &GENOME MAINTENANCE
    David J Stewart; Fiscal Year: 2011
    ..rapid growth in our understanding of the eukaryotic DNA replication process and how it is integrated into the cell division cycle...
  38. Molecular and Cellular Regulation of Mammalian Renal Medulla Development
    Jing Yu; Fiscal Year: 2013
    ..How does Wnt7b and renal interstitial canonical Wnt signaling regulate oriented cell division of the prospective medullary collecting ducts and renal medulla formation? We found that both Wnt7b and renal ..
  39. Dietary Regulation of Pancreatic Digestive Enzymes
    John A Williams; Fiscal Year: 2013
    ..The second form of growth that occurs following tissue injury such as pancreatitis involves dedifferentiation, cell division and dedifferentiation and will be referred to as regeneration...
  40. Mammary Gland Morphogenesis and Breast Cancer
    Ian G Macara; Fiscal Year: 2013
    ..The Par polarity proteins are key regulators of asymmetric cell division. Par proteins also control polarization of differentiated epithelial cells...
  41. Molecular and cellular mechanism of Microcephaly
    Arnold Kriegstein; Fiscal Year: 2013
    ..is noticeably disrupted, underscoring the particular significance of centrosome behavior for asymmetric cell division of progenitor cells and determination of daughter cell fate...
  42. Roles for Global Chromatin Structure in C. elegans Longevity
    Siu Sylvia Lee; Fiscal Year: 2010
    ..is impacted by certain special features of the genome that are stably inherited through multiple rounds of cell division, but do not involve changes in the DNA sequence...
  43. Slow cycling brain tumor cancer stem cells
    BRENT REYNOLDS; Fiscal Year: 2010
    ..One of the defining characteristics of somatic stem cells is their infrequent cell division due to cell cycle arrest, which is essential to prevent premature stem cell depletion over the lifetime of the ..
  44. Centrosomin and Centrosomes in Cell Division
    Timothy L Megraw; Fiscal Year: 2012
    Centrioles and centrosomes are conserved organelles in animals that are essential for cell signaling, cell division, and for specialized roles in differentiated cells, impacting organ function in whole animals...
  45. Mechanisms linking RAS signals to disordered hematopoiesis and myeloid neoplasia
    BENJAMIN BRAUN; Fiscal Year: 2013
    ..MEK is hypothesized to stimulate increased cell division rates and/or survival in GM progenitors, as well as alter the balance of GM vs...
  46. Non-coding RNAs in the epigenetics of human centromere formation
    PETER WARBURTON; Fiscal Year: 2009
    ..human centromeres, the fundamental chromosomal component responsible for proper chromosome segregation during cell division. Defects in chromosome segregation leads to genome instability, which represents a major cause of birth ..
  47. Regulation of Tumor Metabolism by Retinoblastoma Protein
    Brian F Clem; Fiscal Year: 2013
    ..energy production and to drive the de novo biosynthesis of nucleotides, amino acids, and lipids essential for cell division. These processes are primarily driven through oncogenes or loss of tumor suppressors, which act to circumvent ..
  48. Analysis of the Human c-myc Gene Replication Origin
    Michael Leffak; Fiscal Year: 2012
    ..Inappropriate regulation of DNA replication initiation can lead to chromosome fragmentation, abnormal cell division and human disease...
  49. Genetic Analysis of Mouse Nervous System Development
    Kathryn V Anderson; Fiscal Year: 2013
    ..Analysis of the Sas4 mutant phenotype will define whether centrosomes regulate signaling, cell division, cell migration or cell survival...
  50. Cyclin E Regulation in Normal and Neoplastic Hematopoiesis
    ALEXANDER C MINELLA; Fiscal Year: 2013
    ..The investigators recently found that one of the proteins that controls cell division (called "cyclin E"), when it is abnormally regulated, causes defects in blood cell development, some of which ..
  51. Model systems for hematologic disorders caused by ribosomal protein deficiency
    George Thomas; Fiscal Year: 2010
    ..genes for ribosomal proteins is due to the fact that defects in the production of ribosomes cause an arrest in cell division which can result in cell death...
  52. Establishment of sister chromatid cohesion
    Douglas E Koshland; Fiscal Year: 2013
    ..This sister chromatid cohesion is critical to ensure that daughter cells inherit proper ploidy during cell division. Cohesin is also important for mitotic condensation, meiotic chromosome structure, post-replicative DNA repair ..
  53. Novel STIM1-dependent cyclic AMP signaling pathway in colonic epithelial function
    Aldebaran M Hofer; Fiscal Year: 2013
    ..however, inappropriate or persistent elevation of cAMP is expected to cause alterations in gene expression and cell division that may ultimately disrupt the function of the epithelium, or even elicit adenoma formation...
  54. Plk1-Numb Cooperation in Melanomagenesis
    Nihal Ahmad; Fiscal Year: 2013
    ..An in-depth knowledge of the genetic controls of cellular proliferation and cell division may provide critical information regarding melanomagenesis...
  55. Fine-Tuning the Notch Signaling Pathway via O-Glucosylation
    Hamed Jafar-Nejad; Fiscal Year: 2013
    ..Notch signaling is also involved in the regulation of stem cell division and differentiation...
  56. Contribution of Sperm Nucleus to Paternal DNA Replication
    WILLIAM S WARD; Fiscal Year: 2013
    ..This application proposes to test the idea that the sperm cell brings to the egg more than only the DNA, itself, but instructions on how to replicate it properly in the first embryonic cell division.
  57. Design of a high-throughput screen for chemicals that cause meiotic aneuploidy
    Patrick Allard; Fiscal Year: 2011
    ..in a cell, originate from errors in the segregation of chromosomes during the two highly regulated programs of cell division, mitosis and meiosis...
  58. GENETIC ANALYSIS OF BASAL BODY FUNCTION
    Susan K Dutcher; Fiscal Year: 2013
    ..The maturation of centrioles/basal bodies during the cell cycle is likely to play important roles in both asymmetric cell division and signaling.
  59. Determining the Roles of ATRX and DAXX Abnormalities in Cancer Telomere Biology
    ALAN KEITH MEEKER; Fiscal Year: 2013
    ..Telomeres shorten with each cell division;a process that causes eventual cell cycle exit in normal cells...
  60. Genetics of Meiosis and Recombination in Mice
    John C Schimenti; Fiscal Year: 2013
    ..in order to stimulate meiotic recombination - a process essential for proper chromosome segregation upon cell division. Failure to repair the DSBs triggers a checkpoint that results in oocyte elimination...
  61. Oxidative DNA base damage and repair at telomeres and the relevance to cell senes
    PATRICIA LYNN OPRESKO; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Telomeres at chromosome ends shorten during cell division and aging in humans...
  62. Transition State Analogues as Modulators of DNA Methylation
    Vern L Schramm; Fiscal Year: 2012
    ..HEALTH RELEVANCE:Human cancers result from loss of control of the DNA regions that act as regulators for cell division. New drug candidates are being developed to restore normal control to these cell regulators...
  63. DNA Methyltransferase Target Sites in Cancer
    ROCHELLE LEE TIEDEMANN; Fiscal Year: 2013
    ..There are three catalytically active DNMTs: DNMT1 serves as the maintenance methyltransferase during cell division, and DNMT3A and DNMT3B are the de novo methyltransferases that are responsible for establishing methylation ..
  64. Myogenic Potential of Extraocular Muscle Satellite Cells
    Linda K McLoon; Fiscal Year: 2010
    ..in two mouse models of DMD, the mdx and mdx/utrophin+/- (mdx/utrhet) mice, and 2) test whether inhibition of cell division in the EOM prevent their sparing in the two mouse models for DMD...
  65. MEIOTIC CELL CYCLE REGULATION IN REPRODUCTION
    Stuart Ravnik; Fiscal Year: 2002
    ..b>Cell division is regulated, in part, by specific protein kinase complexes...
  66. Cell Division Control and Virulence in Mycobacteria
    William Bishai; Fiscal Year: 2005
    ..Nucleic acid synthesis and levels of the essential cell division protein FtsZ were unaltered by WhmD withdrawal...
  67. Integrating lipid biosynthesis with bacterial cell cycle progression
    Sean Murray; Fiscal Year: 2010
    ..Its asymmetric cell division results in one swarmer and one stalked cell progeny...
  68. METABLASTIN AND THE CONTROL OF CELL DIVISION
    ULRICH SCHUBART; Fiscal Year: 1999
    ..metablastin, a highly conserved cytosolic protein involved in signal transduction, in the control of mammalian cell division. Metablastin is expressed in many immature cells during development and in most cancer cells...
  69. Cytoskeletal organization in apicomplexan parasites
    Heide Schatten; Fiscal Year: 2005
    ..the applicant): The purpose of this research is to understand cytoskeletal organization and functions during cell division of the intracellular protozoan parasite Toxoplasma gondii, a model for harmful apicomplexan parasites that ..
  70. Analysis of the role of patellin in cytokinesis
    T Peterman; Fiscal Year: 2005
    b>Cell division is a central event in the development of all multicellular organisms but it is especially important for plant development...
  71. REGULATION OF CYCLIN/CDK ACTIVITY IN YEAST
    Raymond Deshaies; Fiscal Year: 2000
    In most eukaryotic cells the decision to enter into the cell division cycle is made during the G1 phase...