microsatellite repeats

Summary

Summary: A variety of simple di- (DINUCLEOTIDE REPEATS), tri- (TRINUCLEOTIDE REPEATS), tetra-, and pentanucleotide tandem repeats (usually less than 100 bases long). They are dispersed in the euchromatic arms of most chromosomes.

Top Publications

  1. ncbi Microsatellite null alleles and estimation of population differentiation
    Marie Pierre Chapuis
    Centre de Biologie et de Gestion des Populations, Institut National pour la Recherche Agronomique, Campus International de Baillarguet, Montferrier Lez, France
    Mol Biol Evol 24:621-31. 2007
  2. ncbi Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study
    G Evanno
    Department of Ecology and Evolution, Biology Building, University of Lausanne, CH 1015 Lausanne, Switzerland
    Mol Ecol 14:2611-20. 2005
  3. ncbi Exploiting EST databases for the development and characterization of gene-derived SSR-markers in barley (Hordeum vulgare L.)
    T Thiel
    Institute of Plant Genetics and Crop Plant Research IPK, Corrensstrasse 3, D 06466 Gatersleben, Germany
    Theor Appl Genet 106:411-22. 2003
  4. pmc A genome-scan method to identify selected loci appropriate for both dominant and codominant markers: a Bayesian perspective
    Matthieu Foll
    Laboratoire d Ecologie Alpine, 38041 Grenoble Cedex 09, France
    Genetics 180:977-93. 2008
  5. ncbi Genic microsatellite markers in plants: features and applications
    Rajeev K Varshney
    Institute of Plant Genetics and Crop Plant Research IPK, Corrensstrasse 3, D 06466 Gatersleben, Germany
    Trends Biotechnol 23:48-55. 2005
  6. pmc Discriminant analysis of principal components: a new method for the analysis of genetically structured populations
    Thibaut Jombart
    MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College Faculty of Medicine, St Mary s Campus, Norfolk Place, London W21PG, UK
    BMC Genet 11:94. 2010
  7. pmc Characterization of the sesame (Sesamum indicum L.) global transcriptome using Illumina paired-end sequencing and development of EST-SSR markers
    Wenliang Wei
    Key Laboratory of Oil Crops Biology of the Ministry of Agriculture, Sesame Germplasm and Genetic Breeding Laboratory, Oil Crops Research Institute of Chinese Academy of Agricultural Sciences OCRI CAAS, Wuhan, 430062, China
    BMC Genomics 12:451. 2011
  8. ncbi Microsatellites: simple sequences with complex evolution
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Nat Rev Genet 5:435-45. 2004
  9. ncbi Variable tandem repeats accelerate evolution of coding and regulatory sequences
    Rita Gemayel
    Laboratory for Systems Biology, VIB, B 3001 Heverlee, Belgium
    Annu Rev Genet 44:445-77. 2010
  10. pmc Microsatellites in different eukaryotic genomes: survey and analysis
    G Toth
    Department of Genetics, Eotvos Lorand University, Budapest, Hungary
    Genome Res 10:967-81. 2000

Detail Information

Publications352 found, 100 shown here

  1. ncbi Microsatellite null alleles and estimation of population differentiation
    Marie Pierre Chapuis
    Centre de Biologie et de Gestion des Populations, Institut National pour la Recherche Agronomique, Campus International de Baillarguet, Montferrier Lez, France
    Mol Biol Evol 24:621-31. 2007
    ..montpellier.inra.fr/URLB/. We used 2 published microsatellite data sets based on original and redesigned pairs of primers to empirically confirm our simulation results...
  2. ncbi Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study
    G Evanno
    Department of Ecology and Evolution, Biology Building, University of Lausanne, CH 1015 Lausanne, Switzerland
    Mol Ecol 14:2611-20. 2005
    ..As might be expected, the results are sensitive to the type of genetic marker used (AFLP vs. microsatellite), the number of loci scored, the number of populations sampled, and the number of individuals typed in each sample...
  3. ncbi Exploiting EST databases for the development and characterization of gene-derived SSR-markers in barley (Hordeum vulgare L.)
    T Thiel
    Institute of Plant Genetics and Crop Plant Research IPK, Corrensstrasse 3, D 06466 Gatersleben, Germany
    Theor Appl Genet 106:411-22. 2003
    ....
  4. pmc A genome-scan method to identify selected loci appropriate for both dominant and codominant markers: a Bayesian perspective
    Matthieu Foll
    Laboratoire d Ecologie Alpine, 38041 Grenoble Cedex 09, France
    Genetics 180:977-93. 2008
    ..The method has been implemented in a new software available at our website (http://www-leca.ujf-grenoble.fr/logiciels.htm)...
  5. ncbi Genic microsatellite markers in plants: features and applications
    Rajeev K Varshney
    Institute of Plant Genetics and Crop Plant Research IPK, Corrensstrasse 3, D 06466 Gatersleben, Germany
    Trends Biotechnol 23:48-55. 2005
    ..Applications and potential uses of EST-SSRs in plant genetics and breeding are discussed...
  6. pmc Discriminant analysis of principal components: a new method for the analysis of genetically structured populations
    Thibaut Jombart
    MRC Centre for Outbreak Analysis and Modelling, Department of Infectious Disease Epidemiology, Imperial College Faculty of Medicine, St Mary s Campus, Norfolk Place, London W21PG, UK
    BMC Genet 11:94. 2010
    ..Unfortunately, currently available multivariate methods still lack some essential features needed to study the genetic structure of natural populations...
  7. pmc Characterization of the sesame (Sesamum indicum L.) global transcriptome using Illumina paired-end sequencing and development of EST-SSR markers
    Wenliang Wei
    Key Laboratory of Oil Crops Biology of the Ministry of Agriculture, Sesame Germplasm and Genetic Breeding Laboratory, Oil Crops Research Institute of Chinese Academy of Agricultural Sciences OCRI CAAS, Wuhan, 430062, China
    BMC Genomics 12:451. 2011
    ..High-throughput transcriptomic sequencing is essential to generate a large transcriptome sequence dataset for gene discovery and molecular marker development...
  8. ncbi Microsatellites: simple sequences with complex evolution
    Hans Ellegren
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18D, SE 752 36 Uppsala, Sweden
    Nat Rev Genet 5:435-45. 2004
  9. ncbi Variable tandem repeats accelerate evolution of coding and regulatory sequences
    Rita Gemayel
    Laboratory for Systems Biology, VIB, B 3001 Heverlee, Belgium
    Annu Rev Genet 44:445-77. 2010
    ..As such, TRs combine characteristics of genetic and epigenetic changes that may facilitate organismal evolvability...
  10. pmc Microsatellites in different eukaryotic genomes: survey and analysis
    G Toth
    Department of Genetics, Eotvos Lorand University, Budapest, Hungary
    Genome Res 10:967-81. 2000
    ..Our results suggest that strand-slippage theories alone are insufficient to explain microsatellite distribution in the genome as a whole. Other possible factors contributing to the observed divergence are discussed...
  11. ncbi Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum
    T J Anderson
    Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, Oxford, England
    Mol Biol Evol 17:1467-82. 2000
    ..These data reveal a range of population structures within a single pathogen species and suggest intimate links between patterns of epidemiology and genetic structure in this organism...
  12. ncbi CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
    Daniel J Weisenberger
    Department of Surgery, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California 90089 9176, USA
    Nat Genet 38:787-93. 2006
    ..Sporadic cases of mismatch repair deficiency occur almost exclusively as a consequence of CIMP-associated methylation of MLH1 . We propose a robust new marker panel to classify CIMP+ tumors...
  13. pmc Computational and experimental analysis of microsatellites in rice (Oryza sativa L.): frequency, length variation, transposon associations, and genetic marker potential
    S Temnykh
    Department of Plant Breeding, USDA-ARS Center for Agricultural Bioinformatics, Cornell University, Ithaca, New York 14853-1901, USA
    Genome Res 11:1441-52. 2001
    ..This contribution brings the number of microsatellite markers that have been rigorously evaluated for amplification, map position, and allelic diversity in Oryza spp. to a total of 500...
  14. ncbi Microsatellites: genomic distribution, putative functions and mutational mechanisms: a review
    You Chun Li
    Institute of Evolution, University of Haifa, Haifa 31905, Israel
    Mol Ecol 11:2453-65. 2002
    ..This review also discusses the role of two putative mutational mechanisms, replication slippage and recombination, and their interaction in SSR variation...
  15. ncbi Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum
    John C Wootton
    Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894 6075, USA
    Nature 418:320-3. 2002
    ..The presence of linkage disequilibrium provides a basis for mapping genes under drug selection in P. falciparum...
  16. ncbi Microsatellites within genes: structure, function, and evolution
    You Chun Li
    Institute of Evolution, University of Haifa, Haifa, Israel
    Mol Biol Evol 21:991-1007. 2004
    ..These SSRs may provide a molecular basis for fast adaptation to environmental changes in both prokaryotes and eukaryotes...
  17. ncbi Statistical confidence for likelihood-based paternity inference in natural populations
    T C Marshall
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Mol Ecol 7:639-55. 1998
    ..CERVUS can be used to calculate allele frequencies, run simulations and perform parentage analysis using data from all types of codominant markers...
  18. pmc Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability
    Asad Umar
    Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Natl Cancer Inst 96:261-8. 2004
    ....
  19. pmc Transcriptomics of the bed bug (Cimex lectularius)
    Xiaodong Bai
    Department of Entomology, Ohio Agricultural and Research Development Center, The Ohio State University, Wooster, Ohio, United States of America
    PLoS ONE 6:e16336. 2011
    ..lectularius. Hence, we subjected the C. lectularius transcriptome to 454 pyrosequencing in order to identify potential genes involved in pesticide resistance...
  20. ncbi A high-density microsatellite consensus map for bread wheat (Triticum aestivum L.)
    Daryl J Somers
    Agriculture and Agri Food Canada, Cereal Research Centre, 195 Dafoe Rd, Winnipeg, MB, Canada, R3T 2 M9
    Theor Appl Genet 109:1105-14. 2004
    ..This enables users to predict allele sizes in new breeding populations and develop molecular breeding and genomics strategies...
  21. pmc A genome-wide view of the spectrum of spontaneous mutations in yeast
    Michael Lynch
    Department of Biology, Indiana University, Bloomington, IN 47405, USA
    Proc Natl Acad Sci U S A 105:9272-7. 2008
    ....
  22. ncbi Detecting loci under selection in a hierarchically structured population
    L Excoffier
    Computational and Molecular Population Genetics Lab, Institute of Ecology and Evolution, University of Bern, Bern, Switzerland
    Heredity (Edinb) 103:285-98. 2009
    ..The elimination of false positive loci from genome scans should allow us to better determine on which specific class of genes selection is operating...
  23. ncbi Founding events in species invasions: genetic variation, adaptive evolution, and the role of multiple introductions
    K M Dlugosch
    Ecology and Evolutionary Biology, University of California Santa Cruz, Santa Cruz, California 95064, USA
    Mol Ecol 17:431-49. 2008
    ..We conclude that management limiting gene flow among introduced populations may reduce adaptive potential but is unlikely to prevent expansion or the evolution of novel invasive behaviour...
  24. ncbi Detection of reduction in population size using data from microsatellite loci
    J C Garza
    Department of Integrative Biology, University of California, Berkeley, CA 94720, USA
    Mol Ecol 10:305-18. 2001
    ..This method, and others like it, promises to be an important tool for the conservation and management of populations that are in need of intervention or recovery...
  25. ncbi Hereditary colorectal cancer
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebr 68178, USA
    N Engl J Med 348:919-32. 2003
  26. ncbi How to track and assess genotyping errors in population genetics studies
    A Bonin
    Laboratoire d Ecologie Alpine, CNRS UMR 5553, Universite Joseph Fourier, BP 53, 38041 Grenoble Cedex 09, France
    Mol Ecol 13:3261-73. 2004
    ....
  27. pmc De novo assembly and characterisation of the transcriptome during seed development, and generation of genic-SSR markers in peanut (Arachis hypogaea L.)
    Jianan Zhang
    Institute of Food and Oil Crops, Hebei Academy of Agriculture and Forestry Sciences Laboratory of Crop Genetics and Breeding of Hebei Province, Shijiazhuang, China
    BMC Genomics 13:90. 2012
    ..Recently, next-generation sequencing technology, termed RNA-seq, has provided a powerful approach for analysing the transcriptome, and for shedding light on the molecular biology of peanut...
  28. ncbi SciRoKo: a new tool for whole genome microsatellite search and investigation
    Robert Kofler
    University of Natural Resources and Applied Life Sciences, Department for Agrobiotechnology IFA Tulln, Institute of Biotechnology in Plant Production, 3430 Tulln, Austria
    Bioinformatics 23:1683-5. 2007
    ..Compared to other already existing tools, SciRoKo also allows the analysis of compound microsatellites...
  29. ncbi Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9
    C L Liquori
    Institute of Human Genetics MMC 206, 420 Delaware Street SE, University of Minnesota, Minneapolis, MN 55455, USA
    Science 293:864-7. 2001
    ..Parallels between these mutations indicate that microsatellite expansions in RNA can be pathogenic and cause the multisystemic features of DM1 and DM2...
  30. pmc Gene discovery and tissue-specific transcriptome analysis in chickpea with massively parallel pyrosequencing and web resource development
    Rohini Garg
    National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi 110067, India
    Plant Physiol 156:1661-78. 2011
    ..Most importantly, the data and results reported in this study will help to accelerate research in various areas of genomics and implementing breeding programs in chickpea...
  31. pmc A first-generation microsatellite-based genetic linkage map of the Siberian jay (Perisoreus infaustus): insights into avian genome evolution
    Sonja Jaari
    Ecological Genetics Research Unit, Department of Biological and Environmental Sciences, PO Box 65, FIN 00014 University of Helsinki, Finland
    BMC Genomics 10:1. 2009
    ..Knowledge of its genome structure and organization is required to advance our understanding of the genetic basis of ecologically important traits in this species, as well as to provide insights into avian genome evolution...
  32. ncbi Assessing genetic diversity and population structure in a citrus germplasm collection utilizing simple sequence repeat markers (SSRs)
    Noelle A Barkley
    Department of Botany and Plant Sciences and Graduate Program in Genetics, Genomics, and Bioinformatics, University of California, Riverside, CA 92521, USA
    Theor Appl Genet 112:1519-31. 2006
    ....
  33. pmc Characterization of common carp transcriptome: sequencing, de novo assembly, annotation and comparative genomics
    Peifeng Ji
    The Centre for Applied Aquatic Genomics, Chinese Academy of Fishery Sciences, Beijing, China
    PLoS ONE 7:e35152. 2012
    ..However, there is still no sufficient transcriptome data available. The objective of the project is to sequence transcriptome deeply and provide well-assembled transcriptome sequences to common carp research community...
  34. pmc Rapid microsatellite identification from Illumina paired-end genomic sequencing in two birds and a snake
    Todd A Castoe
    Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado, United States of America
    PLoS ONE 7:e30953. 2012
    ..Given that Illumina Seq-to-SSR is effective, inexpensive, and reliable even for species such as birds that have few SSR loci, it seems that there are now few situations for which prior hybridization is justifiable...
  35. ncbi Microsatellites for ecologists: a practical guide to using and evaluating microsatellite markers
    Kimberly A Selkoe
    Department of Ecology, Evolution and Marine Biology, University of California, Santa Barbara, CA 93106, USA
    Ecol Lett 9:615-29. 2006
    ..To that end, we present a multistep screening process to evaluate candidate loci for inclusion in a genetic study that is broadly targeted to both novice and experienced geneticists alike...
  36. ncbi Evolutionary dynamics of microsatellite DNA
    C Schlotterer
    Institut fur Tierzucht und Genetik, Veterinärmedizinische Universität Wien, Vienna, Austria
    Chromosoma 109:365-71. 2000
    ..g., fragile X and Huntington's disease). A detailed understanding of the processes underlying microsatellite instability is therefore an important contribution toward a better understanding of these human neurodegenerative diseases...
  37. ncbi Strategies for microsatellite isolation: a review
    L Zane
    Dipartimento di Biologia, Università di Padova Via Ugo Bassi 58 B, 35121, Padova, Italy
    Mol Ecol 11:1-16. 2002
    ..In addition, we propose a fast and easy protocol which is a combination of different published methods...
  38. pmc Transcriptome characterization and high throughput SSRs and SNPs discovery in Cucurbita pepo (Cucurbitaceae)
    José Blanca
    Institute for the Conservation and Breeding of Agricultural Biodiversity, Universidad Politécnica de Valencia COMAV UPV, Camino de Vera s n, 46022 Valencia, Spain
    BMC Genomics 12:104. 2011
    ..However, these tools are still lacking in the Cucurbita genus, thus limiting gene discovery and the process of breeding...
  39. ncbi Genetic structure of human populations
    Noah A Rosenberg
    Molecular and Computational Biology, 1042 West 36th Place DRB 289, University of Southern California, Los Angeles, CA 90089, USA
    Science 298:2381-5. 2002
    ..General agreement of genetic and predefined populations suggests that self-reported ancestry can facilitate assessments of epidemiological risks but does not obviate the need to use genetic information in genetic association studies...
  40. pmc A microsatellite map of wheat
    M S Roder
    Institut für Pflanzengenetik und Kulturpflanzenforschung IPK, 06466 Gatersleben, Germany
    Genetics 149:2007-23. 1998
    ..Ninety-three loci were mapped to the A genome, 115 to the B genome, and 71 to the D genome. The markers are randomly distributed along the linkage map, with clustering in several centromeric regions...
  41. pmc Development of a EST dataset and characterization of EST-SSRs in a traditional Chinese medicinal plant, Epimedium sagittatum (Sieb. Et Zucc.) Maxim
    Shaohua Zeng
    Key Laboratory of Pant Germplasm Enhancement and Speciality Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, Hubei 430074, China
    BMC Genomics 11:94. 2010
    ..Here, we report a set of expressed sequence tags (ESTs) and simple sequence repeats (SSRs) identified in these ESTs for E. sagittatum...
  42. ncbi A physical map of the 1-gigabase bread wheat chromosome 3B
    Etienne Paux
    Institut National de la Recherche Agronomique, Université Blaise Pascal INRA UBP, UMR 1095, Genetics Diversity and Ecophysiology of Cereals, Clermont Ferrand, France
    Science 322:101-4. 2008
    ..This physical map establishes a template for the remaining wheat chromosomes and demonstrates the feasibility of constructing physical maps in large, complex, polyploid genomes with a chromosome-based approach...
  43. pmc Inference on population history and model checking using DNA sequence and microsatellite data with the software DIYABC (v1.0)
    Jean Marie Cornuet
    INRA, UMR CBGP INRA IRD Cirad Montpellier SupAgro, Campus International de Baillarguet, CS 30016, F 34988 Montferrier sur Lez cedex, France
    BMC Bioinformatics 11:401. 2010
    ....
  44. ncbi POLYSAT: an R package for polyploid microsatellite analysis
    Lindsay V Clark
    Department of Plant Sciences, Mail Stop 4, University of California, Davis, CA 95616, USA
    Mol Ecol Resour 11:562-6. 2011
    ..This software is freely available through the Comprehensive R Archive Network (http://cran.r-project.org/) and includes a thorough tutorial...
  45. ncbi Reliability of genetic bottleneck tests for detecting recent population declines
    M Zachariah Peery
    Department of Forest and Wildlife Ecology, University of Wisconsin Madison, 1630 Linden Drive, Madison, WI 53706, USA
    Mol Ecol 21:3403-18. 2012
    ..We provide recommendations that could add rigor to inferences drawn from future bottleneck tests and highlight new directions for the characterization of demographic history...
  46. ncbi Homoplasy and mutation model at microsatellite loci and their consequences for population genetics analysis
    Arnaud Estoup
    Centre de Biologie et de Gestion des Populations, Campus International de Baillarguet, 34980 Montferrier Lez, France
    Mol Ecol 11:1591-604. 2002
    ..The situations where size homoplasy may be more problematic involve high mutation rates and large population sizes together with strong allele size constraints...
  47. ncbi Rise of the machines--recommendations for ecologists when using next generation sequencing for microsatellite development
    Michael G Gardner
    School of Biological Sciences, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia
    Mol Ecol Resour 11:1093-101. 2011
    ....
  48. pmc Comparative microsatellite typing of new world leishmania infantum reveals low heterogeneity among populations and its recent old world origin
    Katrin Kuhls
    Institut für Mikrobiologie und Hygiene, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS Negl Trop Dis 5:e1155. 2011
    ..infantum population structure. It confirmed that the agent of VL in the NW is L. infantum and that the parasite has been recently imported multiple times to the NW from southwest Europe...
  49. pmc Genome-wide distribution and organization of microsatellites in plants: an insight into marker development in Brachypodium
    Humira Sonah
    National Research Centre on Plant Biotechnology, Indian Agricultural Research Institute IARI, New Delhi, India
    PLoS ONE 6:e21298. 2011
    ..SSR markers developed in this study would be helpful for genomic studies in Brachypodium and related grass species, especially for the map based cloning of the candidate gene(s)...
  50. ncbi Intercontinental spread of pyrimethamine-resistant malaria
    Cally Roper
    London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Science 305:1124. 2004
    ..The resistance alleles carried by these migrants are now spreading across Africa at an alarming rate, signaling the end of affordable malaria treatment and presenting sub-Saharan Africa with a public health crisis...
  51. ncbi QDD: a user-friendly program to select microsatellite markers and design primers from large sequencing projects
    Emese Meglecz
    Aix Marseille Universite, CNRS, IRD, UMR 6116 IMEP, Equipe Evolution, Génome et Environnement, Centre Saint Charles, Case 36, 3 Place Victor Hugo, 13331 Marseille Cedex 3, France
    Bioinformatics 26:403-4. 2010
    ..It can treat up to one million sequences of a few hundred base pairs in the tag-sorting step, and up to 50,000 sequences in a single input file for the steps involving estimation of sequence similarity...
  52. pmc A genetic map in the Mimulus guttatus species complex reveals transmission ratio distortion due to heterospecific interactions
    L Fishman
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Genetics 159:1701-16. 2001
    ..We discuss possible causes of the unequal representation of parental genomes in the F(2) generation...
  53. ncbi Current trends in microsatellite genotyping
    E Guichoux
    INRA, UMR 1202 Biodiversity Genes and Communities, F 33610 Cestas, France
    Mol Ecol Resour 11:591-611. 2011
    ..To make the most of the latest technical developments, we outline the need for a well-established strategy including standardized high-throughput bench protocols and specific bioinformatic tools, from primer design to allele calling...
  54. pmc Defining the transcriptome assembly and its use for genome dynamics and transcriptome profiling studies in pigeonpea (Cajanus cajan L.)
    Anuja Dubey
    Centre of Excellence in Genomics CEG, Building 300, International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru 502 324, Greater Hyderabad, India
    DNA Res 18:153-64. 2011
    ..Genomic resources developed in this study should be useful for basic and applied research, not only for pigeonpea improvement but also for other related, agronomically important legumes...
  55. pmc Integration of physical and genetic maps in apple confirms whole-genome and segmental duplications in the apple genome
    Yuepeng Han
    Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Moshan, Wuhan, 430074, PR China
    J Exp Bot 62:5117-30. 2011
    ..These findings demonstrated the presence of both genome-wide and segmental duplications in the apple genome and provided further insights into the complex polyploid ancestral origin of the apple...
  56. pmc BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum
    T Kambara
    Conjoint Gastroenterology Laboratory, Royal Brisbane and Women s Hospital Research Foundation and Queensland Institute of Medical Research, Brisbane 4029, Australia
    Gut 53:1137-44. 2004
    ..However, the distribution of BRAF mutations in MSI-H cancers remains to be clarified with respect to precursor lesions and the CpG island methylator phenotype (CIMP)...
  57. pmc A genome-wide microsatellite polymorphism database for the indica and japonica rice
    Zhonghua Zhang
    James D Watson Institute of Genome Science, Zhejiang University, Hangzhou 310008, China
    DNA Res 14:37-45. 2007
    ..Our database will undoubtedly facilitate the application of MS markers in genetic researches and marker-assisted breeding. The data set is freely available from www.wigs.zju.edu.cn/achievment/polySSR...
  58. pmc Transcriptome sequencing and comparative analysis of cucumber flowers with different sex types
    Shaogui Guo
    1National Engineering Research Center for Vegetables, Beijing 100097, China
    BMC Genomics 11:384. 2010
    ....
  59. ncbi Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
    Struan F A Grant
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 38:320-3. 2006
    ..It is thought to act through regulation of proglucagon gene expression in enteroendocrine cells via the Wnt signaling pathway...
  60. pmc South American Plasmodium falciparum after the malaria eradication era: clonal population expansion and survival of the fittest hybrids
    Sean M Griffing
    Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e23486. 2011
    ..Understanding the population substructure of P. falciparum has implications for vaccine, drug, and epidemiologic studies, including monitoring malaria during and after the elimination phase...
  61. ncbi Estimating the probability of identity among genotypes in natural populations: cautions and guidelines
    L P Waits
    Department of Fish and Wildlife Resources, University of Idaho, Moscow, ID 83844 1136, USA
    Mol Ecol 10:249-56. 2001
    ..We suggest computing the actual observed P(ID) when possible and give general guidelines for the number of codominant and dominant marker loci required to achieve a reasonably low P(ID) (e.g. 0.01-0.0001)...
  62. ncbi Simple sequence repeats as advantageous mutators in evolution
    Yechezkel Kashi
    Department of Biotechnology and Food Engineering, Israel Institute of Technology, Haifa 32000, Israel
    Trends Genet 22:253-9. 2006
    ..These studies support the hypothesis that SSRs, by virtue of their special mutational and functional qualities, have a major role in generating the genetic variation underlying adaptive evolution...
  63. pmc Comparative genomics and molecular dynamics of DNA repeats in eukaryotes
    Guy Franck Richard
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, CNRS, URA2171, Universite Pierre et Marie Curie, UFR927, 25 rue du Dr Roux, F 75015, Paris, France
    Microbiol Mol Biol Rev 72:686-727. 2008
    ....
  64. pmc Transcriptomics of a giant freshwater prawn (Macrobrachium rosenbergii): de novo assembly, annotation and marker discovery
    Hyungtaek Jung
    Biogéosciences, Queensland University of Technology, Brisbane, Queensland, Australia
    PLoS ONE 6:e27938. 2011
    ..However, as little is known about its genome, 454 pyrosequencing of cDNA was undertaken to characterise its transcriptome and identify genes important for growth...
  65. pmc What is a microsatellite: a computational and experimental definition based upon repeat mutational behavior at A/T and GT/AC repeats
    Yogeshwar D Kelkar
    Department of Biology, Penn State University, Pennsylvania, USA
    Genome Biol Evol 2:620-35. 2010
    ..These findings have implications for understanding microsatellite mutagenesis, standardization of genome-wide microsatellite analyses, and predicting polymorphism levels of individual microsatellite loci...
  66. pmc High-density integrated linkage map based on SSR markers in soybean
    Tae Young Hwang
    National Agricultural Research Center for Hokkaido Region, Sapporo, Hokkaido 062 8555, Japan
    DNA Res 16:213-25. 2009
    ..8. Our high-density linkage map should facilitate ongoing and future genomic research such as analysis of quantitative trait loci and positional cloning in addition to marker-assisted selection in soybean breeding...
  67. pmc Large-scale transcriptome analysis in chickpea (Cicer arietinum L.), an orphan legume crop of the semi-arid tropics of Asia and Africa
    Pavana J Hiremath
    International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, India
    Plant Biotechnol J 9:922-31. 2011
    ..This resource will be useful for basic and applied research for genome analysis and crop improvement in chickpea...
  68. pmc The genome-wide determinants of human and chimpanzee microsatellite evolution
    Yogeshwar D Kelkar
    Department of Biology, Penn State University, University Park, Pennsylvania 16802, USA
    Genome Res 18:30-8. 2008
    ..Finally, our regression models explain approximately 90% of variation in microsatellite mutability and can generate useful predictions for the studies of human diseases, forensics, and conservation genetics...
  69. pmc Sampling for microsatellite-based population genetic studies: 25 to 30 individuals per population is enough to accurately estimate allele frequencies
    Marie L Hale
    School of Biological Sciences, University of Canterbury, Christchurch, New Zealand
    PLoS ONE 7:e45170. 2012
    ..Therefore, there appears to be little benefit in sampling more than 25 to 30 individuals per population for population genetic studies based on microsatellite allele frequencies...
  70. ncbi Microsatellite null alleles in parentage analysis
    E E Dakin
    Department of Genetics, University of Georgia, Athens, GA 30602, USA
    Heredity (Edinb) 93:504-9. 2004
    ....
  71. pmc ADZE: a rarefaction approach for counting alleles private to combinations of populations
    Zachary A Szpiech
    Center for Computational Medicine and Biology, Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Bioinformatics 24:2498-504. 2008
    ..However, sample sizes often differ across populations, sometimes making it difficult to assess allelic distributions across groups...
  72. ncbi Coral reef fish larvae settle close to home
    Geoffrey P Jones
    Centre for Coral Reef Biodiversity, School of Marine Biology and Aquaculture, James Cook University, Townsville, Qld 4811, Australia
    Curr Biol 15:1314-8. 2005
    ..The degree of local retention indicates that marine reserves can provide recruitment benefits not only beyond but also within their boundaries...
  73. ncbi High-throughput microsatellite isolation through 454 GS-FLX Titanium pyrosequencing of enriched DNA libraries
    Thibaut Malausa
    INRA, UMR 1301 IBSV INRA UNSA CNRS, 400 Route des Chappes, BP 167, 06903 Sophia Antipolis Cedex, France
    Mol Ecol Resour 11:638-44. 2011
    ..This method is expected to speed up the acquisition of high-quality genetic markers for nonmodel organisms...
  74. ncbi Similarity of contemporary and historical gene flow among highly fragmented populations of an endangered rattlesnake
    James E Chiucchi
    Department of Evolution, Ecology and Organismal Biology, Ohio State University, Columbus, OH 43210 1293, USA
    Mol Ecol 19:5345-58. 2010
    ....
  75. ncbi Global invasion history of the fire ant Solenopsis invicta
    Marina S Ascunce
    USDA ARS Center for Medical, Agricultural, and Veterinary Entomology, 1600 1700 Southwest 23rd Drive, Gainesville, FL, USA
    Science 331:1066-8. 2011
    ..These results illustrate in stark fashion a severe negative consequence of an increasingly massive and interconnected global trade and travel system...
  76. pmc The first set of EST resource for gene discovery and marker development in pigeonpea (Cajanus cajan L.)
    Nikku L Raju
    International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, Greater Hyderabad, Andhra Pradesh, India
    BMC Plant Biol 10:45. 2010
    ..With an objective of enhancing genomic resources in pigeonpea, this study reports generation and analysis of comprehensive resource of FW- and SMD- responsive expressed sequence tags (ESTs)...
  77. ncbi Comparing clines on molecular and phenotypic traits in hybrid zones: a window on tension zone models
    Laurene Gay
    CEFE CNRS, UMR 5175, 1919 Route de Mende, F 34293 Montpellier cedex 5, France
    Evolution 62:2789-806. 2008
    ..High-resolution analysis of phenotypes distribution thus proved useful for detecting hybrid zone movement even without temporal data...
  78. ncbi The estimation of population differentiation with microsatellite markers
    Francois Balloux
    Zoologisches Institut, Universitat Bern, CH 3032 Hinterkappelen Bern, Switzerland
    Mol Ecol 11:155-65. 2002
    ..Finally, we discuss the biological interpretation of population structuring estimates...
  79. pmc Local adaptation and vector-mediated population structure in Plasmodium vivax malaria
    Deirdre A Joy
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Mol Biol Evol 25:1245-52. 2008
    ....
  80. pmc A predominantly neolithic origin for European paternal lineages
    Patricia Balaresque
    Department of Genetics, University of Leicester, Leicester, United Kingdom
    PLoS Biol 8:e1000285. 2010
    ....
  81. pmc A generic estimation of population subdivision using distances between alleles with special reference for microsatellite loci
    Y Michalakis
    Laboratoire d Ecologie, Universite P and M Curie CNRS URA 258, Paris, France
    Genetics 142:1061-4. 1996
    ..We discuss the relationships among these estimators and show how a single analysis of variance framework can accomodate these qualitatively different data types...
  82. pmc A high-resolution linkage map for comparative genome analysis and QTL fine mapping in Asian seabass, Lates calcarifer
    Chun Ming Wang
    Molecular Population Genetics Group, Temasek Life Sciences Laboratory, National University of Singapore, Singapore
    BMC Genomics 12:174. 2011
    ..Here, we report a high-resolution linkage map with 790 microsatellites and SNPs, comparative analysis of synteny, fine-mapping of QTL and the identification of potential candidate genes for growth traits...
  83. pmc Bridgehead effect in the worldwide invasion of the biocontrol harlequin ladybird
    Eric Lombaert
    Equipe Biologie des Populations en Interaction, INRA UMR 1301 IBSV INRA CNRS Université de Nice Sophia Antipolis, Sophia Antipolis, France
    PLoS ONE 5:e9743. 2010
    ..e., heightened vigilance against invasive bridgeheads)...
  84. ncbi Multiple transatlantic introductions of the western corn rootworm
    Nicholas Miller
    Biologie des Populations en Interaction, Unité Mixte de Recherche UMR 1112 Institute National de la Recherche Agronomique INRA Université de Nice Sophia Antipolis, 400 Route des Chappes, 06903 Sophia Antipolis Cedex, France
    Science 310:992. 2005
    ..This result raises questions about changing circumstances that have enabled a sudden burst of transatlantic introductions...
  85. pmc Polarity and temporality of high-resolution y-chromosome distributions in India identify both indigenous and exogenous expansions and reveal minor genetic influence of Central Asian pastoralists
    Sanghamitra Sengupta
    Human Genetics Unit, Indian Statistical Institute, Kolkata, India
    Am J Hum Genet 78:202-21. 2006
    ..Our reappraisal indicates that pre-Holocene and Holocene-era--not Indo-European--expansions have shaped the distinctive South Asian Y-chromosome landscape...
  86. pmc A SSR-based composite genetic linkage map for the cultivated peanut (Arachis hypogaea L.) genome
    Yanbin Hong
    Guangdong Academy of Agricultural Sciences, Crops Research Institute, Guangzhou, PR China
    BMC Plant Biol 10:17. 2010
    ....
  87. ncbi Isolating microsatellite DNA loci
    Travis C Glenn
    Savannah River Ecology Laboratory, Savannah River Site, Aiken, South Carolina 29803, USA
    Methods Enzymol 395:202-22. 2005
    ..These protocols have made it possible to reduce the time to identify candidate loci for primer development from most eukaryotic species to as little as 1 week...
  88. ncbi Advances in Arachis genomics for peanut improvement
    Manish K Pandey
    International Crops Research Institute for the Semi Arid Tropics, Patancheru 502324, India
    Biotechnol Adv 30:639-51. 2012
    ..The genome or at least gene space sequence is expected to be available in near future and this will further accelerate use of biotechnological approaches for peanut improvement...
  89. pmc Assembly, gene annotation and marker development using 454 floral transcriptome sequences in Ziziphus celata (Rhamnaceae), a highly endangered, Florida endemic plant
    Christine E Edwards
    USACE ERDC, Environmental Laboratory, 3909 Halls Ferry Road, Vicksburg, MS 39180, USA
    DNA Res 19:1-9. 2012
    ..celata, we identified sequences belonging to the gene family encoding self-incompatibility. This study demonstrates the efficacy of 454 transcriptome sequencing for rapid gene and marker discovery in an endangered plant...
  90. ncbi Transcriptome profiling and molecular marker discovery in red pepper, Capsicum annuum L. TF68
    Fu hao Lu
    Department of Plant Resources, College of Industrial Sciences, Kongju National University, Yesan 340 802, Republic of Korea
    Mol Biol Rep 39:3327-35. 2012
    ..The SSR motifs corresponded to di- and tri- nucleotide motifs (27.03 and 61.92%, respectively). These molecular markers may be of great value for application in linkage mapping and association mapping research...
  91. ncbi Inbreeding depression is purged in the invasive insect Harmonia axyridis
    Benoit Facon
    Institut National pour la Recherche Agronomique, UMR Centre de Biologie pour la Gestion des Populations, Campus International de Baillarguet, Montferrier Lez Cedex, France
    Curr Biol 21:424-7. 2011
    ..Thus, rather than posing a barrier to invasion as often assumed, bottlenecks, by purging deleterious alleles, can enable the evolution of invaders that maintain high fitness even when inbred...
  92. pmc Population genetics as a tool to select tsetse control strategies: suppression or eradication of Glossina palpalis gambiensis in the Niayes of Senegal
    Philippe Solano
    Institut de Recherche pour le Développement IRD Centre International de Recherche pour l Elevage en zones Subhumides CIRDES, UMR 177 IRD Centre de coopération Internationale en Recherche Agronomique pour le Développement CIRAD, CIRDES 01 BP 454, Bobo Dioulasso, Burkina Faso
    PLoS Negl Trop Dis 4:e692. 2010
    ..e. "eradication" versus "suppression." To inform this debate, we used population genetics to measure genetic differentiation between G. palpalis gambiensis from the Niayes and those from the southern tsetse belt (Missira)...
  93. ncbi A quantitative review of heterozygosity-fitness correlations in animal populations
    J R Chapman
    Edward Grey Institute, Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
    Mol Ecol 18:2746-65. 2009
    ....
  94. pmc Integration of novel SSR and gene-based SNP marker loci in the chickpea genetic map and establishment of new anchor points with Medicago truncatula genome
    Spurthi N Nayak
    Centre of Excellence in Genomics CEG, International Crops Research Institute for the Semi Arid Tropics ICRISAT, Patancheru, 502324, Andhra Pradesh, India
    Theor Appl Genet 120:1415-41. 2010
    ..The combined set of genetic markers and their integration into an improved genetic map should facilitate chickpea genetics and breeding, as well as translational studies between chickpea and Medicago...
  95. ncbi Mining microsatellites in eukaryotic genomes
    Prakash C Sharma
    University School of Biotechnology, Guru Gobind Singh Indraprastha University, Kashmere Gate, Delhi 110 006, India
    Trends Biotechnol 25:490-8. 2007
    ..Judicious microsatellite mining not only helps in addressing biological questions but also facilitates better exploitation of microsatellites for diverse applications...
  96. ncbi Analysis of spatial genetic structure in an expanding Pinus halepensis population reveals development of fine-scale genetic clustering over time
    D Troupin
    Movement Ecology Laboratory, Department of Evolution, Systematics and Ecology, The Hebrew University of Jerusalem, Edmond J Safra Campus at Givat Ram, 91904 Jerusalem, Israel
    Mol Ecol 15:3617-30. 2006
    ..The development of SGS may be explained by fine-scale environmental heterogeneity and possibly microenvironmental selection. Inbreeding and variation in reproductive success may have enhanced SGS magnitude over time...
  97. pmc BatchPrimer3: a high throughput web application for PCR and sequencing primer design
    Frank M You
    Department of Plant Sciences, University of California, CA 95616, USA
    BMC Bioinformatics 9:253. 2008
    ..In particular, most programs lack batch primer design capability. Such a high-throughput software tool for designing SSR flanking primers and SNP genotyping primers is increasingly demanded...
  98. ncbi Population structure of Tunisian Leishmania infantum and evidence for the existence of hybrids and gene flow between genetically different populations
    Najla Chargui
    Laboratoire de Parasitologie Mycologie à la Faculté de Pharmacie, 99 UR 08 05 Monastir, Tunisia
    Int J Parasitol 39:801-11. 2009
    ..infantum MON-24 based on genotype data, as well as the existence of hybrids between zymodemes MON-1 and MON-24/MON-80, and proving one of these hybrid strains by molecular analysis of the parent strain and its clones...
  99. pmc Nonrandom distribution and frequencies of genomic and EST-derived microsatellite markers in rice, wheat, and barley
    Mauricio La Rota
    Department of Plant Breeding and Genetics, 240 Emerson Hall, Cornell University, Ithaca, NY 14853, USA
    BMC Genomics 6:23. 2005
    ....
  100. ncbi In silico analysis on frequency and distribution of microsatellites in ESTs of some cereal species
    Rajeev K Varshney
    Institute of Plant Genetics and Crop Plant Research IPK, Corrensstrasse 3, D 06466 Gatersleben, Germany
    Cell Mol Biol Lett 7:537-46. 2002
    ....
  101. ncbi An overview of the apple genome through BAC end sequence analysis
    Yuepeng Han
    Department of Natural Resources and Environmental Sciences, University of Illinois, Urbana, IL 61801, USA
    Plant Mol Biol 67:581-8. 2008
    ..BAC end sequencing can be used to anchor a small proportion of the apple genome to the Populus and possibly to the Arabidopsis genomes...

Research Grants65

  1. Analysis of the Human c-myc Gene Replication Origin
    Michael Leffak; Fiscal Year: 2012
    ..Thus, our studies are likely to provide fundamental new insight into the mechanisms of DNA replication, the origins of genetic diseases, and new models for disease treatment. ..
  2. Male Mutation Bias and Paternal Age Effect in Mammals
    Kateryna Makova; Fiscal Year: 2010
    ..Additionally, the conclusions of this project will be important for genetic counseling. Namely, our results will indicate whether the age of a father at the time of conception represents a risk factor for pathology in the offspring. ..
  3. Second-site genetic modifiers of CTG/CAG microsatellite stability
    Michael Leffak; Fiscal Year: 2013
    ....
  4. Advancing research on the sexually transmitted female 'nuisance' pathogen Trichom
    Jane Carlton; Fiscal Year: 2010
    ....
  5. RNA DOMINANCE IN HUMAN DISEASE
    MAURICE SCOTT SWANSON; Fiscal Year: 2013
    ....
  6. EWS/FLI AND ITS TARGETS IN EWING'S SARCOMA
    Stephen L Lessnick; Fiscal Year: 2013
    ....
  7. Microsatellite Instability and the DNA Mismatch Repair System
    John M Carethers; Fiscal Year: 2013
    ....
  8. Epistasis: its role in complex tratis, gene expression and speciation
    Michael J Wade; Fiscal Year: 2012
    ..abstract_text> ..
  9. Computational and Biochemical Analysis of Microsatellite Life Cycle
    Kateryna Makova; Fiscal Year: 2012
    ..This research could have major consequences for predicting the risk of diseases caused by microsatellites. ..
  10. A Mouse Model for Complex Human Diseases
    James Cheverud; Fiscal Year: 2009
    ..Backcrossing with SM/J will be used to narrow the QTL interval for strain loss and to produce a new strain, carrying the unusual phenotypes of SM/J without requiring enforced heterozygosity at the agouti locus. ..
  11. Modeling Neoplastic Progression in Barrett's Esophagus
    Carlo Maley; Fiscal Year: 2013
    ..abstract_text> ..
  12. Genetic Mapping Resources for Common Mammalian Diseases
    Leslie A Lyons; Fiscal Year: 2013
    ..abstract_text> ..
  13. Convergent Genetic and Genomic Analyses of Schizophrenia
    Ayman H Fanous; Fiscal Year: 2013
    ..In this project, we seek to determine the genetic sequence of individuals with schizophrenia and search for both common and rare mutations. ..
  14. Molecular epidemiology of sulfadoxine-pyrimethamine
    Thomas Egwang; Fiscal Year: 2006
    ..The evolutionary origin of DHFR L164 will be determined by investigating polymorphic microsatellite repeats flanking the dhfr gene...
  15. Genetic Risk Factors for Ewing's Sarcoma
    JOSHUA DAVID SCHIFFMAN; Fiscal Year: 2013
    ..Recent laboratory investigations have revealed that a minimum number of microsatellite repeats are necessary in the promoter regions of the genes affected by the EWS-FLI1 translocation protein...
  16. CELLULAR MECHANISMS OF DRUG REACTIONS IN SCHIZOPHRENIA
    Edmond Yunis; Fiscal Year: 1999
    ..The study of TNF polymorphism in relation to the physiology of cells in the presence of drugs could lead to the development of strategies for the general understanding of drug adverse reactions. ..
  17. The molecular basis for an animal model of inherited hyperuricosuria
    Danika Bannasch; Fiscal Year: 2007
    ..The elucidation of a novel gene function should provide new avenues of investigation for the treatment of the human condition. [unreadable] [unreadable] [unreadable]..
  18. CHARACTERIZING THE ZEBRAFISH GENOME
    Leonard Zon; Fiscal Year: 2002
    ....
  19. Population cytogenetics of Anopheles moucheti and Anopheles nili
    Igor Sharakhov; Fiscal Year: 2009
    ..This proposal offers a unique opportunity to develop cytogenetic research tools and to assess their effectiveness for taxonomic and population genetics studies of the neglected malaria vectors An. moucheti and An. nili. ..
  20. GENETIC POLYMORPHISMS AND DIVERSITY IN MALARIA
    Dyann Wirth; Fiscal Year: 2007
    ..various classes of non-coding DNA, and will address the key issue whether the mutation rate is elevated in microsatellite repeats. Comparisons of coding regions will allow analyses of polymorphism and divergence to test whether ..
  21. The Human Colorectal Instabilitome
    Stephen Meltzer; Fiscal Year: 2007
    ..c.i To utilize PCA components to find genes segregating with MSI status, and SAM to identify genes significantly differentially expressed among these three groups. ..
  22. Genetics of Anorexia Nervosa
    Manfred Fichter; Fiscal Year: 2005
    ..The diagnostic and genetic data and lymphoblastoid cell lines (derived from blood samples) will become part of a national archival resource for genetic studies of AN through the NIMH Genetics Initiative. ..
  23. POPULATION STRUCTURE OF SCHISTOSOMES AND HOST SNAILS
    DENNIS MINCHELLA; Fiscal Year: 2003
    ..abstract_text> ..
  24. POPULATION STRUCTURE OF SCHISTOSOMES AND HOST SNAILS
    DENNIS MINCHELLA; Fiscal Year: 2007
    ..abstract_text> ..
  25. Mechanisms of mutagenisis in 'hot spots' causing cancer
    Barbara Wright; Fiscal Year: 2002
    ..abstract_text> ..
  26. 7th International Conference on Unstable Microsatellites in Human Disease
    Laura P W Ranum; Fiscal Year: 2012
    ..In addition, the format of the Conference and the funding sought herein will promote and ensure the attendance and enhanced education of junior scientists, including graduate students, postdoctoral fellows, and junior faculty. ..
  27. Inducible Transgenic Mouse Model of RNA Toxicity
    MANI MAHADEVAN; Fiscal Year: 2009
    ..There are two types, DM1 and DM2, both being autosomal dominant disorders caused by expansions of microsatellite repeats within non-coding regions of their respective genes...
  28. INSTABILITY OF MICROSATELLITES IN MAMMALIAN CELLS
    ROSANN FARBER; Fiscal Year: 2004
    ..With this marker, mutants can be selected by fluorescence-activated-cell sorting for many of the proposed studies. ..
  29. METHYLATION PROFILING AND RISK OF COLORECTAL CANCER
    Hassan Ashktorab; Fiscal Year: 2007
    ..These studies will help in the detection and _rofiling of genetic changes in the pathway of CRC in AA. ..
  30. Alterations:Mice exposed to N-nitroso metabolites of RDX
    George Cobb; Fiscal Year: 2006
    ..Human exposure to these chemicals is likely since explosives contaminated groundwaters are the sole source of drinking water in some areas. ..
  31. MUTATIONS INDUCED IN HUMAN SPERM BY CANCER THERAPY
    Marvin Meistrich; Fiscal Year: 1999
    ..This information would be extremely valuable in the reproductive counseling of long-term survivors of cancer therapy. ..
  32. AUTOSOMAL DOMINANT FOCAL SEGMENTAL GLOMERULOSCLEROSIS
    Michelle Winn; Fiscal Year: 2004
    ..Information derived from this research will also allow a better understanding of the pathogenesis of nonhereditary forms of FSGS and may provide insights regarding management of the more common idiopathic forms of this disorder. ..
  33. Fine Mapping a Novel Inflammatory Bowel Disease Locus
    Richard Duerr; Fiscal Year: 2005
    ..IBD-associated genetic variants that are identified in this project will be targeted for study in future genetic epidemiological and functional studies. ..
  34. Microsatellite instability and cancer gene expression
    Manuel Perucho; Fiscal Year: 2007
    ..of cancer has been well illustrated through the MMP mechanism: cancerrelated genes that contain microsatellite repeats in their coding regions are specifically mutated in MMP-positive tumors...
  35. Population Genetics of Malaria Parasites in African Highlands
    Guiyun Yan; Fiscal Year: 2007
    ..D. student and establishing a PCR facility for parasite genotyping and drug resistance molecular diagnosis. This research will be conducted as an extension of NIH grant R01 AI50243-04. ..
  36. GENETICS OF ETHANOL INDUCED ACTIVATION
    Kristin Demarest; Fiscal Year: 1999
    ..In addition, the selected lines will be examined both for their response to chlordiazepoxide and for the relationship between the activation response and synaptic activity in the central nucleus of the amygdala (CeA). ..
  37. THE GENOMIC DISTRIBUTION OF HUMAN VARIATION
    Mark Seielstad; Fiscal Year: 2000
    ....
  38. High Fidelity Genomic Cloning And Amplification
    RONALD GODISKA; Fiscal Year: 2007
    ..of its capacity for stable maintenance of otherwise "unclonable" sequences, such as inverted repeats, microsatellite repeats, and large clones of genomic DNA (>8 kb) from AT-rich pathogens, such as Pneumocystis carinii...
  39. Androgen Receptor as a Biomarker in Prostate Cancer Progression
    Ann Hamilton; Fiscal Year: 2007
    ..cells at the time of initial diagnosis and to extract germline DNA from normal tissue to assay CAG and GGC microsatellite repeats in the AR gene...
  40. GENETIC OF BONE STRUCTURAL GEOMETRY: FRAMINGHAM COHORTS
    David Karasik; Fiscal Year: 2006
    ..Linkage analysis will also be combined with family based tests of association with candidate genes that lie under the peak, with additional mapping with single nucleotide polyrnorphisms. ..
  41. High Fidelity Genomic Cloning And Amplification
    RONALD GODISKA; Fiscal Year: 2003
    ..of its capacity for stable maintenance of otherwise "unclonable" sequences, such as inverted repeats, microsatellite repeats, and large clones of genomic DNA (>8 kb) from AT-rich pathogens, such as Pneumocystis carinii...
  42. Development of Peromyscus Genomics
    Michael Felder; Fiscal Year: 2007
    ..Specific information enabled by such a map includes QTL analysis, genetic manipulation and dissection of individual QTLs, and identification of potential candidate genes for individual QTLs. ..
  43. GENETIC STUDY OF HODGKIN'S DISEASE
    YIN YAO; Fiscal Year: 2001
    ..abstract_text> ..
  44. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Nancy Buccola; Fiscal Year: 2007
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  45. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Pablo Gejman; Fiscal Year: 2007
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  46. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Douglas Levinson; Fiscal Year: 2007
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  47. MOLECULAR GENETICS OF SCHIZOPHRENIA
    William Byerley; Fiscal Year: 2006
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  48. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Jeremy Silverman; Fiscal Year: 2006
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  49. MOLECULAR GENETICS OF SCHIZOPHRENIA
    C Cloninger; Fiscal Year: 2006
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  50. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Donald Black; Fiscal Year: 2006
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  51. MOLECULAR GENETICS OF SCHIZOPHRENIA
    FAROOQ AMIN; Fiscal Year: 2006
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  52. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Robert Freedman; Fiscal Year: 2006
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. [unreadable] [unreadable]..
  53. DNA Repair and Mutagenesis in S cerevisiae
    Elaine Sia; Fiscal Year: 2005
    ..The experiments in this proposal are aimed at understanding the processes of mutagenesis and repair of mitochondrial DNA in yeast, however, these studies may lead to insights into similar processes in human mitochondrial DNA. ..
  54. MOLECULAR & CLINICAL EVALUATION OF LOW HDL SYNDROMES
    Michael Miller; Fiscal Year: 2003
    ..Further understanding of the molecular basis of isolated low HDL-C and its potential clinical sequelae (e.g., CAD), may therefore aid in the development of therapeutic strategies to effectively treat this disorder. ..
  55. MOLECULAR GENETICS OF SCHIZOPHRENIA
    Bryan Mowry; Fiscal Year: 2006
    ..The goal of the study is to identify one or more SZ susceptibility genes whose subsequent characterization inmolecular and functional studies will elucidate the pathophysiology and treatment of SZ. ..
  56. GENETIC ANALYSIS OF CHROMOSOME 9P21 IN ORAL CARCINOMA
    Susanne Gollin; Fiscal Year: 2000
    ..to determine 9p21 copy number and identify deletions on a cell by cell basis using a p16 probe, 2) LOH for microsatellite repeats within and around the p16 gene, 3)mutational analysis of CDKN2, 4) characterization of the methylation ..
  57. MOLECULAR PATHOLOGY OF GLIOMAS
    Robert Jenkins; Fiscal Year: 2000
    ..of specific chromosomes and chromosomal regions detected by polymerase chain reaction (PCR) analysis of microsatellite repeats and fluorescent in situ hybridization (FISH)...
  58. A High Density Gene Map of the Canine Genome
    Barbara Trask; Fiscal Year: 2004
    ..abstract_text> ..
  59. The Role of Microsatellite Instability in Cancer
    Harold Garner; Fiscal Year: 2005
    ..2001; Woerner et al., 2001). Microsatellite repeats are common and often polymorphic in mammalian genomes...
  60. Genetics/microsatellite instability in tumor suppressors
    Hanlee Ji; Fiscal Year: 2007
    ..To accomplish this goal, I will screen a cDNA library derived from normal colon tissue for new genes which are susceptible to microsatellite instability mutations. ..
  61. Conference on Unstable Microsatellites & Human Disease
    LAURA RANUM; Fiscal Year: 2007
    ..null ..
  62. SOME DETERMINANTS OF BONE MASS IN THE ELDERLY
    C Johnston; Fiscal Year: 1999
    ..Core B provides biochemical measures of hormones, markers of bone turnover, and calcium absorption for all four projects. ..
  63. SPECIALIZED CENTER OF RESEARCH IN SCLERODERMA
    Frank Arnett; Fiscal Year: 2005
    ..abstract_text> ..
  64. GENETICS OF FAMILIAL FOCAL SEGMENTAL GLOMERULOSCLEROSIS
    L Quarles; Fiscal Year: 2002
    ..Knowledge derived from FFSGS will also allow a better understanding of pathogenesis of non-hereditary forms FSGS and may provide insights regarding management of the more common sporadic forms of this disorder. ..
  65. AB 3730XL, 96 Cap DNA Analyzer
    Jeanette Papp; Fiscal Year: 2006
    ..The model has been discontinued, and will not be supported within two years of the requested funding period. Therefore, it is necessary to replace the 3700s with the requested 3730 instrument. [unreadable] [unreadable] [unreadable]..