tandem repeat sequences

Summary

Summary: Copies of DNA sequences which lie adjacent to each other in the same orientation (direct tandem repeats) or in the opposite direction to each other (inverted tandem repeats).

Top Publications

  1. pmc Tandem repeats finder: a program to analyze DNA sequences
    G Benson
    Department of Biomathematical Sciences, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Nucleic Acids Res 27:573-80. 1999
  2. pmc Intragenic tandem repeats generate functional variability
    Kevin J Verstrepen
    Whitehead Institute for Biomedical Research Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 37:986-90. 2005
  3. pmc Unstable tandem repeats in promoters confer transcriptional evolvability
    Marcelo D Vinces
    FAS Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
    Science 324:1213-6. 2009
  4. ncbi Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis
    Christian Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Dresden, Germany
    Blood 99:4326-35. 2002
  5. ncbi Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline
    A A Aravin
    Department of Animal Molecular Genetics, Institute of Molecular Genetics, 123182, Moscow, Russia
    Curr Biol 11:1017-27. 2001
  6. pmc Evolution of F-box genes in plants: different modes of sequence divergence and their relationships with functional diversification
    Guixia Xu
    State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Xiangshan, Beijing 100093, China
    Proc Natl Acad Sci U S A 106:835-40. 2009
  7. ncbi An investigation of the rigor of interpretation rules for STRs derived from less than 100 pg of DNA
    P Gill
    Forensic Science Service, Priory House, Gooch Street North, B56QQ, Birmingham, UK
    Forensic Sci Int 112:17-40. 2000
  8. ncbi FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
    Louise M Kelly
    Division of Hematology Oncology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Blood 99:310-8. 2002
  9. pmc Genome-wide analysis of tandem repeats in Daphnia pulex--a comparative approach
    Christoph Mayer
    Department of Animal Ecology, Evolution and Biodiversity, Ruhr University Bochum, Bochum, Germany
    BMC Genomics 11:277. 2010
  10. ncbi Tandem repeat polymorphisms: modulators of disease susceptibility and candidates for 'missing heritability'
    Anthony J Hannan
    Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne, VIC 3010, Australia
    Trends Genet 26:59-65. 2010

Detail Information

Publications357 found, 100 shown here

  1. pmc Tandem repeats finder: a program to analyze DNA sequences
    G Benson
    Department of Biomathematical Sciences, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Nucleic Acids Res 27:573-80. 1999
    ..These sequences range in size from 3 kb up to 700 kb. A World Wide Web server interface atc3.biomath.mssm.edu/trf.html has been established for automated use of the program...
  2. pmc Intragenic tandem repeats generate functional variability
    Kevin J Verstrepen
    Whitehead Institute for Biomedical Research Massachusetts Institute of Technology, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Genet 37:986-90. 2005
    ..We propose that variation in intragenic repeat number provides the functional diversity of cell surface antigens that, in fungi and other pathogens, allows rapid adaptation to the environment and elusion of the host immune system...
  3. pmc Unstable tandem repeats in promoters confer transcriptional evolvability
    Marcelo D Vinces
    FAS Center for Systems Biology, Harvard University, 52 Oxford Street, Cambridge, MA 02138, USA
    Science 324:1213-6. 2009
    ..As many as 25% of all gene promoters contain tandem repeat sequences. Genes driven by these repeat-containing promoters show significantly higher rates of transcriptional ..
  4. ncbi Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis
    Christian Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Dresden, Germany
    Blood 99:4326-35. 2002
    ..Constitutive activation may be associated with monocytoid differentiation. A high mutant/wt ratio in ITD-positive patients appears to have a major impact on the prognostic relevance...
  5. ncbi Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline
    A A Aravin
    Department of Animal Molecular Genetics, Institute of Molecular Genetics, 123182, Moscow, Russia
    Curr Biol 11:1017-27. 2001
    ..The analysis of Caenorhabditis elegans mutants impaired with dsRNA-mediated silencing and studies in plants implicate a biological role of dsRNA-mediated silencing as a transposon-repression and antiviral mechanism...
  6. pmc Evolution of F-box genes in plants: different modes of sequence divergence and their relationships with functional diversification
    Guixia Xu
    State Key Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, Xiangshan, Beijing 100093, China
    Proc Natl Acad Sci U S A 106:835-40. 2009
    ..Our results indicate that different F-box families, or different clusters of the same family, have experienced dramatically different modes of sequence divergence, apparently having resulted in adaptive changes in function...
  7. ncbi An investigation of the rigor of interpretation rules for STRs derived from less than 100 pg of DNA
    P Gill
    Forensic Science Service, Priory House, Gooch Street North, B56QQ, Birmingham, UK
    Forensic Sci Int 112:17-40. 2000
    ..The method used is complex, yet can be converted into an expert system. We envisage this to be the next step...
  8. ncbi FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
    Louise M Kelly
    Division of Hematology Oncology, Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Blood 99:310-8. 2002
    ..This model system should be useful to assess the contribution of additional cooperating mutations and to evaluate specific FLT3 inhibitors in vivo...
  9. pmc Genome-wide analysis of tandem repeats in Daphnia pulex--a comparative approach
    Christoph Mayer
    Department of Animal Ecology, Evolution and Biodiversity, Ruhr University Bochum, Bochum, Germany
    BMC Genomics 11:277. 2010
    ..Characteristics of TRs in different genomic regions and among different strands are compared in details for D. pulex and the two model insects Apis mellifera and Drosophila melanogaster...
  10. ncbi Tandem repeat polymorphisms: modulators of disease susceptibility and candidates for 'missing heritability'
    Anthony J Hannan
    Howard Florey Institute, Florey Neuroscience Institutes, University of Melbourne, VIC 3010, Australia
    Trends Genet 26:59-65. 2010
    ..TRPs might provide substantial genetic variability contributing to complex polygenic diseases and could be an important source of the missing heritability evident in SNP-based GWA studies...
  11. ncbi Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene
    Kazuyuki Kawakami
    Department of Surgery, Kanazawa University School of Medicine, Kanazawa 920 8641, Japan
    Cancer Res 63:6004-7. 2003
    ..These results suggest that the double polymorphism in the TS tandem repeat sequence, the SNP and the VNTR, may provide a potential for more effective prediction of the clinical outcome of 5-fluorouracil-based chemotherapy...
  12. ncbi A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels
    Michael V Mandola
    Department of Molecular Biology, The University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford, New Jersey 08084, USA
    Pharmacogenetics 14:319-27. 2004
    ..A 6 bp deletion polymorphism in the thymidylate synthase (TS) gene was investigated in order to determine its function...
  13. ncbi The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia
    Rosemary E Gale
    Department of Haematology, Royal Free and University College Medical School, University College London, 98 Chenies Mews, London, UK
    Blood 111:2776-84. 2008
    ..Patients with high FLT3/ITD mutant level (greater than 50%) or FLT3/ITD(+) in the absence of an NPM1 mutation may be good candidates for more experimental therapeutic approaches...
  14. pmc Molecular origins of rapid and continuous morphological evolution
    John W Fondon
    Eugene McDermott Center for Human Growth and Development and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
    Proc Natl Acad Sci U S A 101:18058-63. 2004
    ..The high frequency and incremental effects of repeat length mutations provide molecular explanations for swift, yet topologically conservative morphological evolution...
  15. pmc The profile of repeat-associated histone lysine methylation states in the mouse epigenome
    Joost H A Martens
    Research Institute of Molecular Pathology IMP, The Vienna Biocenter, Vienna, Austria
    EMBO J 24:800-12. 2005
    ..Our data define a profile of repressive histone lysine methylation states for the repetitive complement of four distinct mouse epigenomes and suggest tandem repeats and dsRNA as primary triggers for more stable chromatin imprints...
  16. ncbi Role of transposable elements in heterochromatin and epigenetic control
    Zachary Lippman
    Watson School of Biological Sciences and Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nature 430:471-6. 2004
    ..This probably accounts for the regulation by DDM1 and the DNA methyltransferase MET1 of the euchromatic, imprinted gene FWA, as its promoter is provided by transposable-element-derived tandem repeats that are associated with siRNAs...
  17. pmc XSTREAM: a practical algorithm for identification and architecture modeling of tandem repeats in protein sequences
    Aaron M Newman
    Biomolecular Science and Engineering Program, University of California, Santa Barbara, CA 93106, USA
    BMC Bioinformatics 8:382. 2007
    ..While many software tools have been designed to detect DNA tandem repeats (TRs), useful algorithms for identifying protein TRs with varied levels of degeneracy are still needed...
  18. ncbi Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain
    Hitoshi Kiyoi
    Department of Infectious Diseases, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Oncogene 21:2555-63. 2002
    ..These findings indicate that the FLT3 JM domain plays an important role in receptor activation, and that the length-mutated JM domain induces ligand-independent receptor activation but also activates Wt-FLT3 in a trans-manner...
  19. pmc Background-dependent effects of polyglutamine variation in the Arabidopsis thaliana gene ELF3
    Soledad Francisca Undurraga
    Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:19363-7. 2012
    ..In fact, the Col-ELF3 allele, encoding the shortest known ELF3 polyQ tract, was haploinsufficient in Ws × Col F(1) hybrids. Our data support a model in which variable polyQ tracts drive adaptation to internal genetic environments...
  20. ncbi Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin
    Bernhard Lehnertz
    Research Institute of Molecular Pathology IMP, The Vienna Biocenter, Dr Bohrgasse 7, A 1030 Vienna, Austria
    Curr Biol 13:1192-200. 2003
    ..H3-K9 methylation was recently shown to be a prerequisite for DNA methylation in Neurospora crassa and Arabidopsis thaliana. Currently, it is unknown whether a similar dependence exists in mammalian organisms...
  21. ncbi Tandem repeat sequence variation as causative cis-eQTLs for protein-coding gene expression variation: the case of CSTB
    Christelle Borel
    Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland
    Hum Mutat 33:1302-9. 2012
    ..More broadly, we propose that polymorphic tandem repeats may represent the causative variation of a fraction of cis-eQTLs in the genome...
  22. ncbi Evidence for linkage of a tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4) with attention deficit hyperactivity disorder (ADHD)
    J T McCracken
    Department of Psychiatry and Biobehavioral Scienes, UCLA Neuropsychiatric Institute, Mental Retardation Research Center, UCLA School of Medicine, Los Angeles, CA 90024 1759, USA
    Mol Psychiatry 5:531-6. 2000
    ..These data add further support for the role of DRD4 variants conferring increased risk for ADHD, and imply that additional studies of DRD4 and other related genes are needed...
  23. ncbi A msp1alpha polymerase chain reaction assay for specific detection and differentiation of Anaplasma marginale isolates
    A E Lew
    Queensland Department of Primary Industries, Agency for Food and Fibre Sciences, c o Animal Research Institute, Locked Mail Bag No 4, Qld 4105, Moorooka, Australia
    Vet Microbiol 86:325-35. 2002
    ..The method is sensitive and specific for A. marginale. Although additional msp1alpha products were amplified from at least two Australian isolates, the results suggest limited introduction of A. marginale into Australia...
  24. pmc Genotyping of Bacillus anthracis strains based on automated capillary 25-loci multiple locus variable-number tandem repeats analysis
    Florigio Lista
    Army Medical Research Center, Via Santo Stefano Rotondo 4 00184 Rome Italy
    BMC Microbiol 6:33. 2006
    ..However in an emergency situation, faster genotyping and access to representative databases is necessary...
  25. ncbi Concordance and population studies along with stutter and peak height ratio analysis for the PowerPlex ® ESX 17 and ESI 17 Systems
    Carolyn R Hill
    National Institute of Standards and Technology, Chemical Science and Technology Laboratory, Gaithersburg, MD 20899 8312, USA
    Forensic Sci Int Genet 5:269-75. 2011
    ....
  26. pmc TRStalker: an efficient heuristic for finding fuzzy tandem repeats
    Marco Pellegrini
    CNR, Istituto di Informatica e Telematica, Via Moruzzi 1, 56124 Pisa, Italy
    Bioinformatics 26:i358-66. 2010
    ..Fuzzy TRs are also important as tools to shed light on the evolutionary history of the genome, where higher divergence correlates with more remote duplication events...
  27. pmc Effects of environmental stress on stability of tandem repeats in Escherichia coli O157:H7
    Michael B Cooley
    Produce Safety and Microbiology Research Unit, USDA Agricultural Research Service, 800 Buchanan St, Albany, CA 94710, USA
    Appl Environ Microbiol 76:3398-400. 2010
    ..The pO157 plasmid was frequently lost under these stress conditions. Environmental stresses may increase phylogenetic diversity as measured by MLVA...
  28. pmc Protein tandem repeats - the more perfect, the less structured
    Julien Jorda
    Centre de Recherches de Biochimie Macromoleculaire, CNRS UMR 5237, University of Montpellier 1 and 2, France
    FEBS J 277:2673-82. 2010
    ..Our study supports the hypothesis that, in general, the repeat perfection is a sign of recent evolutionary events rather than of exceptional structural and (or) functional importance of the repeat residues...
  29. ncbi T-REKS: identification of Tandem REpeats in sequences with a K-meanS based algorithm
    Julien Jorda
    Centre de Recherches de Biochimie Macromoléculaire UMR 5237, CNRS, University of Montpellier 1 and 2, Montpellier, France
    Bioinformatics 25:2632-8. 2009
    ..Nevertheless, our tests showed that there is still room for improvement of methods for accurate and rapid detection of tandem repeats in proteins...
  30. pmc Halibut mitochondrial genomes contain extensive heteroplasmic tandem repeat arrays involved in DNA recombination
    Kenneth A Mjelle
    Department of Fisheries and Natural Sciences, Bodø University College, N 8049 Bodø, Norway
    BMC Genomics 9:10. 2008
    ....
  31. ncbi The correlated evolution of Runx2 tandem repeats, transcriptional activity, and facial length in carnivora
    K E Sears
    Pediatrics Department, Howard Hughes Medical Institute, University of Colorado at Denver and Health Sciences Center, 12800 East, 19th Avenue, Aurora, CO 80045, USA
    Evol Dev 9:555-65. 2007
    ....
  32. ncbi Multilocus variable-number tandem repeat analysis of Vibrio cholerae O1 El Tor strains harbouring classical toxin B
    Seon Young Choi
    International Vaccine Institute, Seoul, Republic of Korea
    J Med Microbiol 59:763-9. 2010
    ....
  33. ncbi STAR: an algorithm to Search for Tandem Approximate Repeats
    Olivier Delgrange
    Universite de Mons Hainaut, Service d Informatique Générale, Avenue du Champ de Mars, 6, Mons, 7000, Belgique and LIRMM, CNRS UMR 5506, 161, Rue Ada, Montpellier Cedex 5, 34392, France
    Bioinformatics 20:2812-20. 2004
    ..Nevertheless, they are not systematically detected nor annotated in genome projects. Partially because of this lack of data, their evolution is still poorly understood...
  34. pmc Evolution and control of imprinted FWA genes in the genus Arabidopsis
    Ryo Fujimoto
    Department of Integrated Genetics, National Institute of Genetics, Mishima, Shizuoka, Japan
    PLoS Genet 4:e1000048. 2008
    ..The possible significance of epigenetic variation in reproductive strategies during evolution is also discussed...
  35. pmc Molecular genetic identification of skeletal remains from the Second World War Konfin I mass grave in Slovenia
    Irena Zupanic Pajnic
    Institute of Forensic Medicine, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000 Ljubljana, Slovenia
    Int J Legal Med 124:307-17. 2010
    ..The statistical analyses showed a high confidence of correct identification for all 28 victims in the Konfin I mass grave (posterior probability ranged from 99.9% to more than 99.999999%)...
  36. pmc Remodeling of the chromatin structure of the facioscapulohumeral muscular dystrophy (FSHD) locus and upregulation of FSHD-related gene 1 (FRG1) expression during human myogenic differentiation
    Beatrice Bodega
    Department of Biology and Genetics for Medical Sciences, University of Milan, Milan, Italy
    BMC Biol 7:41. 2009
    ..Furthermore, a mouse model overexpressing FRG1 has been generated, displaying skeletal muscle defects...
  37. ncbi Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia
    S Meshinchi
    The Fred Hutchinson Cancer Research Center, and University of Washington Medical Center, Seattle, WA 98103, USA
    Blood 97:89-94. 2001
    ..002). Multivariate analysis demonstrated that presence of the Flt3/ITD was the single most significant, independent prognostic factor for poor outcome (P =.009) in pediatric AML...
  38. ncbi A novel multiplex for simultaneous amplification of 20 Y chromosome STR markers
    John M Butler
    Biotechnology Division, National Institute of Standards and Technology, 100 Bureau Drive, Mail Stop 8311, Gaithersburg, MD 20899, USA
    Forensic Sci Int 129:10-24. 2002
    ..Haplotype comparisons between the 20plex and a commercially available kit found excellent agreement across the 76 samples in the Y chromosome consortium panel...
  39. pmc RNA-mediated trans-communication can establish paramutation at the b1 locus in maize
    Mario Arteaga-Vazquez
    BIO5 Institute and Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 107:12986-91. 2010
    ..In addition, we uncovered a role for mop1 in the biogenesis of a subset of microRNAs (miRNAs) and show that it functions at the level of production of the primary miRNA transcripts...
  40. ncbi The development of reduced size STR amplicons as tools for analysis of degraded DNA
    John M Butler
    Biotechnology Division, National Institute of Standards and Technology, Gaithersburg, MD 20899 8311, USA
    J Forensic Sci 48:1054-64. 2003
    ..These miniplex sets should prove valuable in the analysis of samples where allele dropout and reduced sensitivity of larger STR alleles occurs...
  41. ncbi Tandem repeats over the edit distance
    Dina Sokol
    Department of Computer and Information Science, Brooklyn College of the City University of New York, Brooklyn, NY, USA
    Bioinformatics 23:e30-5. 2007
    ..Although tandem repeats have been used by biologists for many years, there are few tools available for performing an exhaustive search for all tandem repeats in a given sequence...
  42. ncbi Activation mechanisms of STAT5 by oncogenic Flt3-ITD
    Chunaram Choudhary
    Department of Medicine, Interdisciplinary Center for Clinical Research, University of Munster, Munster, Germany
    Blood 110:370-4. 2007
    ..Furthermore, in vitro kinase assays revealed that STAT5 is a direct target of Flt3. Taken together, our data provide the mechanistic basis of STAT5 activation by Flt3-ITD...
  43. ncbi Characterization of the functional domain of major surface protein 1a involved in adhesion of the rickettsia Anaplasma marginale to host cells
    Jose De La Fuente
    Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, 250 McElroy Hall, 74078 2007, Stillwater, OK, USA
    Vet Microbiol 91:265-83. 2003
    ..These studies demonstrated that the tandemly repeated region of the protein mediates the adhesive function of MSP1a...
  44. ncbi Structure and evolution of the mitochondrial control region of the pollen beetle Meligethes thalassophilus (Coleoptera: Nitidulidae)
    Emiliano Mancini
    Dipartmento di Biologia Animale e dell Uomo, Sapienza Universita di Roma, Viale dell Universita, Rome, Italy
    Genome 51:196-207. 2008
    ..Finally, the technical difficulties found in isolating the mtDNA CR in beetles are remarked upon...
  45. pmc Relapsing fever spirochetes contain chromosomal genes with unique direct tandemly repeated sequences
    Cyril Guyard
    Rocky Mountain Laboratories, 903 S Fourth St, Hamilton, MT 59840, USA
    Infect Immun 73:3025-37. 2005
    ..These polymorphic proteins may be involved in the pathogenicity of these relapsing fever spirochetes and provide a mechanism for antigenic heterogeneity within their populations...
  46. ncbi Short tandem repeat-based identification of individuals and parents
    M Tracey
    Biological Sciences Florida International University, University Park 11200 8th St, Miami, FL 33199, USA
    Croat Med J 42:233-8. 2001
    ....
  47. pmc Development of variable-number tandem repeat typing of Mycobacterium bovis: comparison of results with those obtained by using existing exact tandem repeats and spoligotyping
    Solvig Roring
    Department of Veterinary Science, Queen s University Belfast, Belfast, Northern Ireland
    J Clin Microbiol 40:2126-33. 2002
    ..VNTR typing was shown to be a valuable technique with great potential for further development and application to epidemiological tracing of tuberculosis transmissions...
  48. pmc APE1 incision activity at abasic sites in tandem repeat sequences
    Mengxia Li
    Laboratory of Molecular Gerontology, National Institute on Aging Intramural Research Program, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD 21224, USA
    J Mol Biol 426:2183-98. 2014
    ....
  49. ncbi The complete mitochondrial genome of the Senegal sole, Solea senegalensis Kaup. Comparative analysis of tandem repeats in the control region among soles
    Manuel Manchado
    IFAPA Centro El Toruño, 11500 El Puerto de Santa Maria, Cadiz, Spain
    DNA Seq 18:169-75. 2007
    ..senegalensis. Phylogenetic analysis showed that 7 out of 9 of haplotypes bearing three copies grouped in a separate cluster. Possible mechanisms influencing the evolution of control region among soles are discussed...
  50. ncbi SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML
    Hannes Leischner
    Department of Internal Medicine III, Klinikum rechts der Isar, Technical University of Munich, Ismaningerstrasse 22, Munich, Germany
    Blood 119:4026-33. 2012
    ..SRC inhibition and knock-down blocked STAT5 activation and proliferation induced by FLT3-ITD but not by FLT3-TKD. We conclude that SRC might be a therapeutic target in FLT3-ITD(+) AML...
  51. ncbi The role of tandem duplicator phenotype in tumour evolution in high-grade serous ovarian cancer
    Charlotte K Y Ng
    Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK
    J Pathol 226:703-12. 2012
    ..8% of cases show patterns of aberrations similar to the tandem duplicator, and this phenotype is mutually exclusive with BRCA1/2 carrier mutations...
  52. pmc Markov models of amino acid substitution to study proteins with intrinsically disordered regions
    Adam M Szalkowski
    Swiss Institute of Bioinformatics, Lausanne, Switzerland
    PLoS ONE 6:e20488. 2011
    ..Here, we propose an evolutionary approach to study IDPs, and contrast patterns specific to ordered protein regions and the corresponding IDRs...
  53. pmc Characterization of DXZ4 conservation in primates implies important functional roles for CTCF binding, array expression and tandem repeat organization on the X chromosome
    Christine R McLaughlin
    Department of Biological Science, Florida State University, 319 Stadium Drive, 3076 King Building, Tallahassee, FL 32306 4295, USA
    Genome Biol 12:R37. 2011
    ..While not obviously protein coding, its chromatin organization suggests differing roles for the array on the active and inactive X chromosomes...
  54. ncbi Functional centromeres in soybean include two distinct tandem repeats and a retrotransposon
    Ahmet L Tek
    Research Institute for Bioresources, Okayama University, Chuo 2 20 1, Kurashiki, 710 0046, Japan
    Chromosome Res 18:337-47. 2010
    ..The possible allopolyploid origin of the soybean genome is discussed in view of the centromeric satellite sequences present...
  55. ncbi Inappropriate gene activation in FSHD: a repressor complex binds a chromosomal repeat deleted in dystrophic muscle
    Davide Gabellini
    Howard Hughes Medical Institute, Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 110:339-48. 2002
    ..Based upon these results, we propose that deletion of D4Z4 leads to the inappropriate transcriptional derepression of 4q35 genes resulting in disease...
  56. pmc Comparative analyses of human single- and multilocus tandem repeats
    Darren Ames
    BIO5 Institute and Department of Plant Sciences, University of Arizona, Tucson, Arizona 85719, USA
    Genetics 179:1693-704. 2008
    ..Using our collated parameters, we identified 2230 slTRs as candidates for highly informative molecular markers...
  57. ncbi Finding approximate tandem repeats in genomic sequences
    Ydo Wexler
    Computer Science Department, Technion, Technion Campus, Haifa, 32000, Israel
    J Comput Biol 12:928-42. 2005
    ..The ideas and methods underlying the algorithm are described and its effectiveness on genomic data is demonstrated...
  58. ncbi Beyond tandem repeats: complex pattern structures and distant regions of similarity
    Amy M Hauth
    Department of Computer Sciences, University of Wisconsin Madison, 1210 W Dayton Ave, Madison, WI 53706, USA
    Bioinformatics 18:S31-7. 2002
    ..We study recognition algorithms for two complex pattern structures: variable length tandem repeats (VLTRs) and multi-period tandem repeats (MPTRs)...
  59. ncbi Dynamic mutations as digital genetic modulators of brain development, function and dysfunction
    Jess Nithianantharajah
    Howard Florey Institute, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia
    Bioessays 29:525-35. 2007
    ....
  60. ncbi FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia
    Adam J Mead
    Department of Haematology, Royal Free and University College Medical School, London, United Kingdom
    Blood 110:1262-70. 2007
    ....
  61. pmc Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice
    Li Li
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 118:4935-45. 2011
    ..Thus, the WT FLT3 allele seemingly functions as a tumor suppressor, attenuating the function of the FLT3/ITD allele in leukemia harboring FLT3/ITD mutations...
  62. ncbi Coding repeat instability in the FLO11 gene of Saccharomyces yeasts
    Manuel Fidalgo
    Centro Andaluz de Biologia del Desarrollo, Universidad Pablo de Olavide CSIC, Sevilla, Spain
    Yeast 25:879-89. 2008
    ..Thus, not only variations in the number of intragenic repeats but also the abundance and/or distribution of the different repetitive units may have phenotypic and evolutionary implications...
  63. ncbi mutL as a genetic switch of bacterial mutability: turned on or off through repeat copy number changes
    Fang Chen
    Genomics Research Center, Harbin Medical University, China
    FEMS Microbiol Lett 312:126-32. 2010
    ....
  64. ncbi Multilocus sequence typing (MLST) analysis of Vibrio cholerae O1 El Tor isolates from Mozambique that harbour the classical CTX prophage
    Je Hee Lee
    International Vaccine Institute, San 4 8 Bongcheon 7 Dong, Kwanak gu, Seoul, 151 818, Republic of Korea
    J Med Microbiol 55:165-70. 2006
    ..The possible origin of these isolates and the presence of the tandem repeat of the classical prophage in them implicate the presence of the classical CTX phage...
  65. ncbi Targeted inhibition of FLT3 overcomes the block to myeloid differentiation in 32Dcl3 cells caused by expression of FLT3/ITD mutations
    Rui Zheng
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Blood 100:4154-61. 2002
    ..CEP-701 and other FLT3 inhibitors may be useful for overcoming the block to differentiation (as well as the block to apoptosis) in the leukemic cells of patients with AML...
  66. ncbi DNA typing from skeletal remains: evaluation of multiplex and megaplex STR systems on DNA isolated from bone and teeth samples
    A Alonso
    , , Madrid, Spain
    Croat Med J 42:260-6. 2001
    ....
  67. pmc New variable-number tandem-repeat markers for typing Mycobacterium avium subsp. paratuberculosis and M. avium strains: comparison with IS900 and IS1245 restriction fragment length polymorphism typing
    Virginie C Thibault
    UR1282, Infectiologie Animale, Santé Publique IASP 311, INRA Centre de Tours, F 37380 Nouzilly, France
    J Clin Microbiol 45:2404-10. 2007
    ..These results indicate a substantial degree of genetic drift among different vaccine preparations, which has important implications for prophylactic approaches...
  68. pmc mreps: Efficient and flexible detection of tandem repeats in DNA
    Roman Kolpakov
    French Russian Institute for Informatics and Applied Mathematics, Moscow University, 119899 Moscow, Russia
    Nucleic Acids Res 31:3672-8. 2003
    ..The mreps web interface is accessible through http://www.loria.fr/mreps/...
  69. ncbi Megasatellites: a new class of large tandem repeats discovered in the pathogenic yeast Candida glabrata
    Agnès Thierry
    Unité de Génétique Moléculaire des Levures, Institut Pasteur, CNRS URA2171, Université Pierre et Marie Curie UFR 927, 25 rue du Dr Roux, 75015, Paris, France
    Cell Mol Life Sci 67:671-6. 2010
    ..Their putative role in promoting genome rearrangements by interfering with DNA replication will also be discussed...
  70. ncbi Long tandem repeats as a form of genomic copy number variation: structure and length polymorphism of a chromosome 5p repeat in control and schizophrenia populations
    Heather A Bruce
    Departments of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Psychiatr Genet 19:64-71. 2009
    ..We therefore carried out a pilot experiment to explore the potential role of long tandem repeats as risk factors in psychiatric disorders...
  71. ncbi The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence
    James F Burrows
    Department of Microbiology and Immunology, Queen s University, Whitla Medical Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland
    Genomics 85:524-9. 2005
    ....
  72. ncbi Paramutation's properties and puzzles
    Vicki L Chandler
    BIO5 Institute, Department of Plant Sciences, University of Arizona, Tucson, AZ 85719, USA
    Science 330:628-9. 2010
    ..Transcribed, noncoding tandem repeats and proteins implicated in RNA-directed transcriptional silencing in plants and yeast are required for paramutation, yet the specific molecules mediating heritable silencing remain to be determined...
  73. ncbi High prevalence of methicillin resistant Staphylococcus aureus in pigs
    A J De Neeling
    National Institute for Public Health and the Environment, Bilthoven, The Netherlands
    Vet Microbiol 122:366-72. 2007
    ....
  74. pmc Analysis of the largest tandemly repeated DNA families in the human genome
    Peter E Warburton
    Deptartment of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA
    BMC Genomics 9:533. 2008
    ..Tandemly Repeated DNA represents a large portion of the human genome, and accounts for a significant amount of copy number variation. Here we present a genome wide analysis of the largest tandem repeats found in the human genome sequence...
  75. ncbi Generation and characterization of anti-MUC4 monoclonal antibodies reactive with normal and cancer cells in humans
    Nicolas Moniaux
    Department of Biochemistry and Molecular Biology and Eppley Institute for Research in Cancer and Allied Disease, University of Nebraska Medical Center, Omaha, Nebraska 68198 4525, USA
    J Histochem Cytochem 52:253-61. 2004
    ..Anti-MUC4 MAb may represent a powerful tool for the study of MUC4 function under normal and pathological conditions and for diagnosis of solid tumors including those in the breast, pancreas, lungs, and ovaries...
  76. pmc Rearrangement of the JC virus regulatory region sequence in the bone marrow of a patient with rheumatoid arthritis and progressive multifocal leukoencephalopathy
    Angela Marzocchetti
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurovirol 14:455-8. 2008
    ..Further studies will be needed to determine the prevalence of JCV in bone marrow of immunosuppressed individuals at risk of PML and characterize the RR and phenotype of these JCV isolates...
  77. pmc The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time
    Lev A Zhivotovsky
    N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
    Am J Hum Genet 74:50-61. 2004
    ..This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria...
  78. pmc Single-nucleotide repeat analysis for subtyping Bacillus anthracis isolates
    Chad W Stratilo
    Chemical and Biological Defence Section, Defence R and D Canada Suffield Medicine Hat, AB, CBDS, P O Box 4000, Station Main, Medicine Hat, Alberta T1A 8K6, Canada
    J Clin Microbiol 44:777-82. 2006
    ..The resulting SNR marker system can be used as a molecular epidemiological tool in a natural outbreak or bioterrorism event, offering the best chance of distinguishing very closely related isolates...
  79. ncbi Characterization of new miniSTR loci to aid analysis of degraded DNA
    Michael D Coble
    Biotechnology Division, National Institute of Standards and Technology, Gaithersburg, MD 20899 8311, USA
    J Forensic Sci 50:43-53. 2005
    ..The utility of these new loci were confirmed in comparing the success of the miniSTR assays for typing degraded bone samples while partial profiles were observed with the majority of the samples using a commercial STR kit...
  80. pmc Coding tandem repeats generate diversity in Aspergillus fumigatus genes
    Emma Levdansky
    Department of Human Microbiology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel
    Eukaryot Cell 6:1380-91. 2007
    ..This variation may provide the functional diversity in cell surface antigens which allows rapid adaptation to the environment and/or elusion of the host immune system...
  81. pmc Copy number variation shapes genome diversity in Arabidopsis over immediate family generational scales
    Seth DeBolt
    Plant Physiology Biochemistry Molecular Biology Program, Department of Horticulture, University of Kentucky, USA
    Genome Biol Evol 2:441-53. 2010
    ..Results support a model whereby segmental CNV and the genes encoded within these regions contribute to adaptive capacity of plants through natural genome variation...
  82. ncbi Hypomethylation is restricted to the D4Z4 repeat array in phenotypic FSHD
    J C de Greef
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Neurology 69:1018-26. 2007
    ....
  83. ncbi Laser microdissection separation of pure spermatozoa from epithelial cells for short tandem repeat analysis
    Christine T Sanders
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA
    J Forensic Sci 51:748-57. 2006
    ..This report describes an efficient, low-manipulation LMD method for the efficient separation of spermatozoa from two-donor sperm/epithelial cell mixtures...
  84. ncbi Polymorphisms of the repeated sequences in the enhancer region of the thymidylate synthase gene promoter may predict downstaging after preoperative chemoradiation in rectal cancer
    E Villafranca
    Department of Oncology, Clinica Universitaria, University of Navarre, Pamplona, Spain
    J Clin Oncol 19:1779-86. 2001
    ..Tumor downstaging correlates with improved local control and disease-free survival. The aim of this study is to correlate TR polymorphisms with downstaging and disease-free survival...
  85. ncbi Gene duplication and biased functional retention of paralogs in bacterial genomes
    Dirk Gevers
    Bioinformatics and Evolutionary Genomics, Ghent University Flanders Interuniversity Institute for Biotechnology VIB, Technologiepark 927, B 9052 Ghent, Belgium
    Trends Microbiol 12:148-54. 2004
  86. ncbi FLT3 internal tandem duplication mutations in adult acute myeloid leukaemia define a high-risk group
    F M Abu-Duhier
    Division of Molecular and Genetic Medicine, Royal Hallamshire Hospital, Sheffield, UK
    Br J Haematol 111:190-5. 2000
    ..0096). This study demonstrates that the FLT3 ITD mutation occurs in a significant percentage of adult AML cases and is an important adverse prognostic factor that appears independent of conventional karyotypic findings...
  87. ncbi Distribution of the tandem repeat sequences and karyotyping in cucumber (Cucumis sativus L.) by fluorescence in situ hybridization
    Y H Han
    National Maize Improvement Center of China, Key Laboratory of Crop Genetic Improvement and Genome Ministry of Agriculture, China Agricultural University, Beijing, China
    Cytogenet Genome Res 122:80-8. 2008
    ..The distribution pattern of several tandem repeat sequences (Type I/II, Type III and Type IV) on cucumber chromosomes was visualized using fluorescence in situ ..
  88. pmc Two-step recruitment of RNA-directed DNA methylation to tandem repeats
    Simon W L Chan
    Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Biol 4:e363. 2006
    b>Tandem repeat sequences are frequently associated with gene silencing phenomena...
  89. ncbi Second generation subtyping: a proposed PulseNet protocol for multiple-locus variable-number tandem repeat analysis of Shiga toxin-producing Escherichia coli O157 (STEC O157)
    Eija Hyytia-Trees
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Foodborne Pathog Dis 3:118-31. 2006
    ..An additional more extensive multi-laboratory validation of the MLVA protocol is in progress in order to address critical issues such as establishing epidemiologically relevant interpretation guidelines for the MLVA data...
  90. ncbi Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study
    S P Whitman
    The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 61:7233-9. 2001
    ....
  91. pmc Specific loss of histone H3 lysine 9 trimethylation and HP1gamma/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD)
    Weihua Zeng
    Department of Biological Chemistry, School of Medicine, University of California, Irvine, California, United States of America
    PLoS Genet 5:e1000559. 2009
    ..Based on these results, we propose a new model in which the epigenetic change initiated at 4q D4Z4 spreads its effect to other genomic regions, which compromises muscle-specific gene regulation leading to FSHD pathogenesis...
  92. ncbi Standardisation of multiplex fluorescent short tandem repeat analysis for chimerism testing
    F Nollet
    Clinic and Laboratory of Haematology, AZ Sint-Jan AV, Ruddershove 10, B-8000 Bruges, Belgium
    Bone Marrow Transplant 28:511-8. 2001
    ..By monitoring 26 allogeneic peripheral blood stem cell transplants, the applicability of the proposed method was demonstrated...
  93. pmc Centromeric retroelements and satellites interact with maize kinetochore protein CENH3
    Cathy Xiaoyan Zhong
    Department of Plant Biology, University of Georgia, Athens, Georgia 30602, USA
    Plant Cell 14:2825-36. 2002
    ..Approximately 38 and 33% of CentC and CRM are precipitated in the chromatin immunoprecipitation assay, consistent with data showing that much, but not all, of CENH3 colocalizes with CentC...
  94. pmc Short tandem repeat sequences in the Mycoplasma genitalium genome and their use in a multilocus genotyping system
    Liang Ma
    Section of Infectious Diseases, Department of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    BMC Microbiol 8:130. 2008
    ..genitalium using the newly developed system...
  95. ncbi Scientific standards for studies in forensic genetics
    Peter M Schneider
    Institute of Legal Medicine, University of Cologne, Melatenguertel 60 62, D 50858 Cologne, Germany
    Forensic Sci Int 165:238-43. 2007
    ....
  96. ncbi Application of Y-chromosomal STR haplotypes to forensic genetics
    J Henke
    Institut fuer Blutgruppenforschung, Hohenzollernring 57, D 50672 Koeln, Germany
    Croat Med J 42:292-7. 2001
    ..In forensic genetics, Y-chromosomal STR polymorphisms are highly welcomed as an additional tool...
  97. ncbi Divergence and transcriptional analysis of the division cell wall (dcw) gene cluster in Neisseria spp
    Lori A S Snyder
    The Sir William Dunn School of Pathology, Univrsity of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Mol Microbiol 47:431-42. 2003
    ....
  98. pmc Progressive loss of DNA methylation releases epigenetic gene silencing from a tandemly repeated maize Myb gene
    Rajandeep S Sekhon
    Department of Crop and Soil Sciences, The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA
    Genetics 181:81-91. 2009
    ..We show here that multiple developmental cycles may be required for complete disruption of suppressed epigenetic states and appearance of heritable phenotypes...
  99. ncbi Satellite DNAs between selfishness and functionality: structure, genomics and evolution of tandem repeats in centromeric (hetero)chromatin
    Miroslav Plohl
    Department of Molecular Genetics, Ruder Boskovic Institute, Bijenicka 54, HR 10002 Zagreb, Croatia
    Gene 409:72-82. 2008
    ..This feature may be crucial for long-term stability of DNA-protein interactions in centromeric regions...
  100. ncbi Variability of the tandem repeat region of the Escherichia coli tolA gene
    Kai Zhou
    Laboratory of Food Microbiology and Leuven Food Science and Nutrition Research Centre, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, B 3001 Leuven, Belgium
    Res Microbiol 163:316-22. 2012
    ..Using this system, Cm-resistant revertants with a TR contraction were recovered at a frequency of 1.1 × 10(-7), and contraction was shown to be recA-dependent and enhanced in a DNA repair-deficient mutS background...
  101. ncbi No association of the dopamine DRD4 receptor (DRD4) gene polymorphism with attention deficit hyperactivity disorder (ADHD) in the Irish population
    Z Hawi
    Department Genetics, Trinity College, Dublin, Ireland
    Am J Med Genet 96:268-72. 2000
    ..Therefore, it is unlikely that the DRD4 7-repeat allele is associated with ADHD in the Irish population...

Research Grants62

  1. Assembly and Maintenance of Centromeres in Filamentous Fungi
    Michael Freitag; Fiscal Year: 2013
    ....
  2. A Validated Resource of Thyroid Cancer Cell Lines for Pathway Discovery
    JEFFREY ALLEN KNAUF; Fiscal Year: 2010
    ....
  3. Pharmacogenomics of CVD risk Reduction
    ALAN SHULDINER; Fiscal Year: 2009
    ..The proposed studies will provide important insights into clopidogrel and TZD response, will have important implications for the prevention and treatment of CVD in millions of Americans. ..
  4. Specification of alternate siRNA biogenesis pathways in Arabidopsis
    TODD LUCAS BLEVINS; Fiscal Year: 2011
    ..The diversity of RNA silencing systems in Arabidopsis, loss-of-function mutants in key proteins, and ability to rescue mutations using tagged proteins allows us to scrutinize molecular interactions that generate and channel siRNAs. ..
  5. Donor Stem Cells, Campath, T/B Cell Regulation In HLA-Identical Renal Transplants
    Joshua Miller; Fiscal Year: 2010
    ..The goal in lay terms is to eliminate long-term immunosuppression risks and costs. ..
  6. Control of Mucin Glycan Branching in Membrane-bound and Secreted Mucins
    Pi Wan Cheng; Fiscal Year: 2010
    ..The knowledge gained could help design strategy to develop therapeutic agents to treat patients with mucus hypersecretory lung diseases and cancer. ..
  7. Variation, functions, and dynamics of human subtelomeres
    Barbara J Trask; Fiscal Year: 2010
    ..This research will illuminate the significance of subtelomeric genomics and epigenetics in normal phenotypic variation among humans, as well as in inherited disorders, cancer, and aging. ..
  8. Biological roles of galectins
    GERARDO RAUL VASTA; Fiscal Year: 2013
    ....
  9. Trekking with the Ribognome: Single Molecule Microscopy of Intracellular miRNPs
    Nils G Walter; Fiscal Year: 2010
    ..e., the detection of multiple targets in parallel) possible? Can multiple tandem repeat sequences in a DNA target be detected? Can protein assembly, particularly that occurring during protein misfolding ..
  10. Genetic Analysis of Human First Trimester Trophoblast in Ongoing Pregnancies
    Michael Peter Diamond; Fiscal Year: 2013
    ..The methodologies developed in this investigation could eventually establish clinical tests that use TCS, providing information on the genetic status of the fetus before development has progressed beyond the first two months. ..
  11. Novel Influenza A Nanovaccines for Broad Cross Protection
    Baozhong Wang; Fiscal Year: 2013
    ..We will study immune responses induced by different nanovaccine combinations, the cross protection to challenge by a panel of influenza A viral strains, and immune correlates of the cross protection. ..
  12. STRONG HEART FAMILY STUDY
    Shelley A Cole; Fiscal Year: 2011
    ..End of Abstract) ..
  13. Functional Analysis of FEN-1 Nuclease in Genome Stability and Cancers
    Binghui Shen; Fiscal Year: 2013
    ..2) To determine the role of FEN1/WRN complex in maintaining the stability of tandem repeat sequences and cancer avoidance...
  14. Dopaminergic variants involved in smoking behavior: A perfusion fMRI study
    Teresa R Franklin; Fiscal Year: 2010
    ..Ultimately, if a brain/behavioral/genetic endophenotype can be determined in advance of treatment, smoking cessation treatments can be structured to meet individual needs. ..
  15. Multidrug-Resistant Acinetobacter baumannii
    Yohei Doi; Fiscal Year: 2010
    ..Such knowledge will help in optimizing use of existing antibiotics and improving infection control practices. ..
  16. The Influence of Dopaminergic Genetic Variants on D2-like Receptors in Drinkers
    Amira K Brown; Fiscal Year: 2011
    ....
  17. In Vitro Reconstitution and Biochemical Characterization of Yeast Telomerase
    KAREN ADELL LEWIS; Fiscal Year: 2012
    ....
  18. O-Glycans on Mucins at the Ocular Surface
    PABLO ARGUESO; Fiscal Year: 2013
    ..abstract_text> ..
  19. Phylogenomic epidemiology of Clostridium difficile
    Seth T Walk; Fiscal Year: 2013
    ..A combination of coursework, mentorship from leaders in the field, and experiential knowledge to be gained from in depth data analysis will ensure the success of the research and the future career of the candidate. ..
  20. Structural Basis of Actin Cytoskeleton Dynamics
    Roberto Dominguez; Fiscal Year: 2013
    ..The knowledge gained here will be of great relevance to understanding the molecular mechanisms of disease. ..
  21. The Rate and Molecular Spectrum of Spontaneous Mutations
    Michael Lynch; Fiscal Year: 2009
    ....
  22. IMMUNITY IN TRANSGENIC MICE
    Erik Selsing; Fiscal Year: 2010
    ..If ? transgene translocations also do not involve AID then this would provide a convenient model system for genetic analyses of the sequences and proteins important for the IgH translocation process. ..
  23. Prediction and Design of Nucleic Acid Recognition by Repeat Proteins
    Philip Bradley; Fiscal Year: 2013
    ....
  24. Variability in Brain Function Underlying Motivated Behavior in Adolescence
    Beatriz Luna; Fiscal Year: 2013
    ....
  25. MOLECULAR PATHOGENESIS OF BLASTOMYCOSIS
    BRUCE STEVEN KLEIN; Fiscal Year: 2013
    ..Our work will resolve the molecular and structural bases of BIastomcyes virulence and define how BAD1 is regulated and controlled coordinately with other yeast-phase genes, which is a key event in fungal pathogenesis. ..
  26. Characterizing a cue-vulnerable pharmaco-responsive endophenotype in smokers
    Teresa R Franklin; Fiscal Year: 2013
    ....
  27. Genetics of Longevity in Long-Lived Siblings
    Sangkyu Kim; Fiscal Year: 2010
    ..My research plan is focused on isolating the genetic factors that are shared by the exceptionally longevous family members. ..
  28. The Genetic Epidemiology of COPD in Costa Rica
    JUAN CARLOS CELEDON; Fiscal Year: 2009
    ..This application will greatly contribute to our understanding of the pathogenesis of COPD in general, and among Hispanics in particular. ..
  29. Role of Staphylococcus aureus SpA in Microbial Competition and Host Colonization
    Paul J Planet; Fiscal Year: 2013
    ..2) Determine the primary elements of the human innate immune response that are triggered by Xr leading to clearance of other flora. ..
  30. Effects of SLC6A4, BDNF and Ecstasy Use on Brain Structure in Young Adults
    Krista Lisdahl Medina; Fiscal Year: 2010
    ..This information will help tailor drug prevention and biologically based intervention programs. ..
  31. Genetics of Familial Epilepsy Syndromes
    Annapurna Poduri; Fiscal Year: 2013
    ..The goal of this project is to gain deeper insight into the fundamental causes of epilepsy by studying the genetics of familial forms of epilepsy. ..
  32. Granulin specific monoclonal antibodies to investigate their expression and role
    Ginette Serrero; Fiscal Year: 2013
    ..abstract_text> ..
  33. Design and Characterization of a Single-chain Hemoglobin
    Spencer J Anthony Cahill; Fiscal Year: 2010
    ..The goal of this research is to address the projected shortfall in blood needed for transfusion, by developing a safe and efficacious red cell substitute based on modification of the human hemoglobin protein. ..
  34. Ehrlichia Type-1 Secreted Effectors Exploit Host SUMO Pathways
    Jere W McBride; Fiscal Year: 2013
    ....
  35. Mechanisms of Error Prone Repair of DNA Breaks
    Sang Eun Lee; Fiscal Year: 2013
    ..Recombination between tandem repeat sequences is an evolutionary conserved error prone mechanism that repairs DNA breaks by producing sequence ..
  36. Topoisomerase 1 and mutagenesis in yeast
    Sue Jinks-Robertson; Fiscal Year: 2013
    ..Given the universality of DNA structure and basic DNA metabolic processes, results in the yeast system will be relevant to issues of genome stability in higher eukaryotes. ..
  37. Gene x Environment Effects on PTSD
    Nathan A Kimbrel; Fiscal Year: 2013
    ..In turn, this training will enable him to develop and implement a programmatic line of G x E and G x G research focused on the etiology of PTSD among Veterans. ..
  38. CHROMATIN HISTONE MODIFICATIONS AND HMG PROTEINS
    EDWIN BRADBURY; Fiscal Year: 1992
    ....
  39. Youth Drug Abuse, ADHD and Related Disruptive Behaviors
    Ken C Winters; Fiscal Year: 2011
    ..Also, the addition of genetic variables further strengthens our search for underlying factors that contribute to variability in developmental pathways. ..
  40. Integrating SNPs and STRPs in Population Genetics
    Bret A Payseur; Fiscal Year: 2012
    ..Project Relevance: This project will examine the properties of different classes of human DNA variation. The results will help reveal the causes of the genetic variation that underlies complex inherited diseases. ..
  41. MOLECULAR ANALYSIS OF MUCIN TYPE O GLYCOSYLATION
    Michael Hollingsworth; Fiscal Year: 2000
    ....
  42. MECHANISMS OF MYCOPLASMA-INDUCED ARTHRITIS
    Kevin Dybvig; Fiscal Year: 2009
    ..An understanding of the inability of 158-1 to resist host defenses may offer an unique opportunity to explore interactions between the mycoplasma and innate immunity. ..
  43. GENE DISCOVERY FOR THE KENNY CAFFEY SYNDROME
    Bruce Gelb; Fiscal Year: 2000
    ..abstract_text> ..
  44. TRANSCRIPTION IN TRYPANOSOMATID CRITHIDIA FASCICULATA
    Abram Gabriel; Fiscal Year: 1991
    ..The overall goal of this proposal is to acquire the didactic training and laboratory experience necessary for the Investigator to become an independent biomedical scientist...
  45. MUTATIONAL MECHANISMS OF REPETITIVE DNA IN HUMAN CELLS
    Kristin Eckert; Fiscal Year: 2001
    ..Our long-term research objective is to test the hypothesis that mutations in repetitive DNA provide an important source of genotypic variation that drives neoplastic progression. ..
  46. DOMAIN STABILITY AND INTERACTIONS IN CD4
    Christie Brouillette; Fiscal Year: 1993
    ..Also, we have begun to use the V1V2 crystal structure to design new mutants to establish the quantitative importance of specific residues in V1, including residues at the V1-V2 interface, to gp120 recognition...
  47. FRAMEWORK LINKAGE MAPS OF HUMAN CHROMOSOMES 10 & 20
    Tim Keith; Fiscal Year: 1993
    ..The framework maps will be considered complete when telomere probes are incorporated and when the informativeness and spacing of the collected markers meet the criteria specified by this RFA...
  48. TRYPANOSOME GENE EXPRESSION AND ENVIRONMENTAL ADAPTATION
    GEORGE CROSS; Fiscal Year: 1993
    ..The first one to be attempted will be malate dehydrogenase; alternatives include phosphoenolpyruvate carboxykinase and adenylate kinase...
  49. Tandemly Repetitive Proteins in Mycoplasmas
    KEVIN F DYBVIG; Fiscal Year: 2010
    ..By understanding the role of repetitive proteins in the disease process, it is anticipated that improved measures to control the infections of these significant human pathogens will be developed. ..
  50. Diagnostic analyses of endogenous protein interactions
    Ulf Landegren; Fiscal Year: 2009
    ..The procedures and results of this project will establish protein interaction events as markers for tumor diagnostics, and for evaluation of drug treatment. ..
  51. GENE PROBES IN THE FAMMM
    Henry Lynch; Fiscal Year: 1990
    ..Given the technology available to us, this may lead to the identification of the deleterious gene...
  52. The genetic bases of reading and related processes in Russian
    Elena L Grigorenko; Fiscal Year: 2012
    ..g., sequencing). ..
  53. Genomic Plasticity in the Human U2 snRNA Cluster
    Alan Weiner; Fiscal Year: 2006
    ..Our studies could shed light on cell cycle control of transcription, higher order chromosome structure, the molecular mechanisms of chromosome instability in cancer, and the causes of Cockayne Syndrome. ..
  54. GENETICS OF HLA-D AND T-CELL RECEPTOR HAPLOTYPES
    Hugh McDevitt; Fiscal Year: 1991
    ....
  55. IMMUNOGENIC TUMOR ASSOCIATED MUCIN PEPTIDES
    Simon Sherman; Fiscal Year: 2004
    ....
  56. ROLE OF TUMOR CELL SURFACE LECTIN IN METASTASIS
    Avraham Raz; Fiscal Year: 2006
    ....
  57. Molecular typing of Mycobacterium leprae
    Varalakshmi Vissa; Fiscal Year: 2005
    ..leprae in the transmission of leprosy via nasal or dermal routes of ntry and release of the pathogen and the differentiation of relapse from reinfection in patients. ..
  58. Longevity Genes in Founder Populations
    ALAN SHULDINER; Fiscal Year: 2005
    ..These advances will impact substantially on the health and quality of life of older Americans. ..
  59. FLUORESCENCE STUDIES OF NUCLEOSOME STRUCTURAL CHANGES
    ENOCH SMALL; Fiscal Year: 1992
    ..Finally, the fluorescence of DNA- intercalating probes will enable us to examine the torsional flexibility of the DNA in the various chromatin preparations...
  60. Polymorphisms of Neural NOS and the Asthma Phenotype
    Michael Wechsler; Fiscal Year: 2005
    ....
  61. Joint Determinants of Bone Density and CVD Calcification
    Braxton Mitchell; Fiscal Year: 2004
    ..Such insights could lead to elucidation of specific genetic pathways that can be exploited in the future for early identification of high-risk individuals, as well as development of new preventive and therapeutic approaches...
  62. Studies of germinal center B cell survival
    Hector Martinez Valdez; Fiscal Year: 2009
    ..The B cell-targeted deletion will be obtained by breeding mice carrying the floxed PRELI gene with mice expressing CD19-driven Cre-recombinase. ..