genetic processes

Summary

Summary: Those biological processes that are involved in the transmission of hereditary traits from one organism to another.

Top Publications

  1. pmc Propylnitrosourea-induced T-lymphomas in LEXF RI strains of rats: genetic analysis
    L M Lu
    Department of Pathology and Biology of Disease, Graduate School of Medicine, Kyoto University, Japan
    Br J Cancer 80:855-61. 1999
  2. pmc Phylogeography of the Solanaceae-infecting Basidiomycota fungus Rhizoctonia solani AG-3 based on sequence analysis of two nuclear DNA loci
    Paulo C Ceresini
    ETH Zurich Swiss Federal Institute of Technology, IBZ, Universitaetstrasse 2, LFW B28, 8092 Zurich, Switzerland
    BMC Evol Biol 7:163. 2007
  3. ncbi Resilience in the aftermath of terrorism and during warzone exposure: Is it religiousness or is it number of blood relatives?
    H Stefan Bracha
    J Clin Psychiatry 67:1156; author reply 1156-7. 2006
  4. ncbi Teaching molecular genetics: Chapter 1--Background principles and methods of molecular biology
    Nine V A M Knoers
    Department of Human Genetics, University Medical Centre Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Pediatr Nephrol 21:169-76. 2006
  5. ncbi An introduction to genetics. The first article in a series about the significance of genetic science for Catholic health care
    Jeffrey G Shaw
    Cancer Center, Penrose St Francis Health Services, Colorado Springs, CO, USA
    Health Prog 86:46-52. 2005
  6. ncbi Generalist genes and cognitive neuroscience
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Number P080, Institute of Psychiatry, DeCrespigny Park, London, SE5 8AF, United Kingdom
    Curr Opin Neurobiol 16:145-51. 2006
  7. ncbi Roles for nutrients in epigenetic events
    Anna M Oommen
    Department of Nutrition and Health Sciences, University of Nebraska at Lincoln, Lincoln, NE 68583 0806, USA
    J Nutr Biochem 16:74-7. 2005
  8. ncbi Proteome analysis of Halobacterium sp. NRC-1 facilitated by the biomodule analysis tool BMSorter
    Rueichi R Gan
    Institute of Biochemistry, National Yang Ming University, Taipei City Hospital, Taipei 112, Taiwan, Republic of China
    Mol Cell Proteomics 5:987-97. 2006
  9. ncbi Poly(ADP-ribose). The most elaborate metabolite of NAD+
    Alexander Burkle
    Department of Biology, University of Konstanz, Germany
    FEBS J 272:4576-89. 2005
  10. ncbi Basic genetics
    Bruce R Korf
    Department of Genetics, University of Alabama at Birmingham, 1530 3rd Avenue, South Kaul 230, Birmingham, AL 35294, USA
    Prim Care 31:461-78, vii. 2004

Detail Information

Publications202 found, 100 shown here

  1. pmc Propylnitrosourea-induced T-lymphomas in LEXF RI strains of rats: genetic analysis
    L M Lu
    Department of Pathology and Biology of Disease, Graduate School of Medicine, Kyoto University, Japan
    Br J Cancer 80:855-61. 1999
    ..These observations indicate that PNU-induced lymphomagenesis is a multifactorial genetic process involving a number of loci linked with susceptibility and resistance...
  2. pmc Phylogeography of the Solanaceae-infecting Basidiomycota fungus Rhizoctonia solani AG-3 based on sequence analysis of two nuclear DNA loci
    Paulo C Ceresini
    ETH Zurich Swiss Federal Institute of Technology, IBZ, Universitaetstrasse 2, LFW B28, 8092 Zurich, Switzerland
    BMC Evol Biol 7:163. 2007
    ..solani AG-3 on potato and tobacco are shaped by population genetic processes. In this study, two field populations of R...
  3. ncbi Resilience in the aftermath of terrorism and during warzone exposure: Is it religiousness or is it number of blood relatives?
    H Stefan Bracha
    J Clin Psychiatry 67:1156; author reply 1156-7. 2006
  4. ncbi Teaching molecular genetics: Chapter 1--Background principles and methods of molecular biology
    Nine V A M Knoers
    Department of Human Genetics, University Medical Centre Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Pediatr Nephrol 21:169-76. 2006
    ..In addition, several basic and frequently used general molecular tools, such as restriction enzymes, Southern blotting, DNA amplification and sequencing are discussed, in order to lay the foundations for the forthcoming chapters...
  5. ncbi An introduction to genetics. The first article in a series about the significance of genetic science for Catholic health care
    Jeffrey G Shaw
    Cancer Center, Penrose St Francis Health Services, Colorado Springs, CO, USA
    Health Prog 86:46-52. 2005
  6. ncbi Generalist genes and cognitive neuroscience
    Lee M Butcher
    Social, Genetic and Developmental Psychiatry Centre, Number P080, Institute of Psychiatry, DeCrespigny Park, London, SE5 8AF, United Kingdom
    Curr Opin Neurobiol 16:145-51. 2006
    ....
  7. ncbi Roles for nutrients in epigenetic events
    Anna M Oommen
    Department of Nutrition and Health Sciences, University of Nebraska at Lincoln, Lincoln, NE 68583 0806, USA
    J Nutr Biochem 16:74-7. 2005
    ....
  8. ncbi Proteome analysis of Halobacterium sp. NRC-1 facilitated by the biomodule analysis tool BMSorter
    Rueichi R Gan
    Institute of Biochemistry, National Yang Ming University, Taipei City Hospital, Taipei 112, Taiwan, Republic of China
    Mol Cell Proteomics 5:987-97. 2006
    ..Thus this study demonstrated that proteome analysis can provide useful information and help systems analyses of organisms...
  9. ncbi Poly(ADP-ribose). The most elaborate metabolite of NAD+
    Alexander Burkle
    Department of Biology, University of Konstanz, Germany
    FEBS J 272:4576-89. 2005
    ..In this article, the most recent advances in this rapidly growing field are summarized...
  10. ncbi Basic genetics
    Bruce R Korf
    Department of Genetics, University of Alabama at Birmingham, 1530 3rd Avenue, South Kaul 230, Birmingham, AL 35294, USA
    Prim Care 31:461-78, vii. 2004
    ..Definitions of terms that appear here in italics can be found in the on-line, illustrated glossary at www.genetests.org...
  11. ncbi Mutual benefit can promote the evolution of preferential interactions and in this way can lead to the evolution of true altruism
    Laureano Castro
    Departamento de Mejora Genética Animal, SGIT INIA, Carretera de la Coruña Km 7, Madrid 28040, Spain
    Theor Popul Biol 65:239-47. 2004
    ..This requires that the tag used in the election of partners is the altruistic or selfish behaviour itself...
  12. pmc SIR repression of a yeast heat shock gene: UAS and TATA footprints persist within heterochromatin
    E A Sekinger
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, Shreveport, LA 71130 3932, USA
    EMBO J 18:7041-55. 1999
    ..it is unclear how this structure blocks transcription while remaining fully permissive to other genetic processes such as recombination or integration...
  13. ncbi Enzymatic DNA methylation is an epigenetic control for genetic functions of the cell
    B F Vanyushin
    Belozersky Institute of Physico Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia
    Biochemistry (Mosc) 70:488-99. 2005
    ..DNA methylation controls all genetic processes in the cell (replication, transcription, DNA repair, recombination, gene transposition) and it is a ..
  14. ncbi Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis
    Dennie G A J Hebels
    Department of Health Risk Analysis and Toxicology, Maastricht University, 6200 MD Maastricht, The Netherlands
    Toxicol Sci 108:290-300. 2009
    ..is an important route of exposure through endogenous nitrosation, we hypothesize that NOC exposure targets genetic processes relevant in colon carcinogenesis...
  15. ncbi Genetic expression by fetal chorionic villi during the first trimester of human gestation
    D S Dizon Townson
    Departments of Obstetrics and Gynecology and Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Am J Obstet Gynecol 183:706-11. 2000
    ..sequence of events that consists of cellular adhesion and limited invasion controlled by relatively unknown genetic processes. We hypothesized that genes expressed by first-trimester chorionic villi constitute critical regulators of ..
  16. pmc GeneMesh: a web-based microarray analysis tool for relating differentially expressed genes to MeSH terms
    Saurin D Jani
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    BMC Bioinformatics 11:166. 2010
    ....
  17. ncbi Limbs in whales and limblessness in other vertebrates: mechanisms of evolutionary and developmental transformation and loss
    Lars Bejder
    Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J1
    Evol Dev 4:445-58. 2002
    ..Selective pressures acting on a wide range of developmental processes and adult traits other than the limbs are likely to have driven the loss of hindlimbs in whales...
  18. ncbi SOX9 is not required for the cellular events of testicular organogenesis in XX mole ovotestes
    F David Carmona
    Departamento de Genética e Instituto de Biotecnología, Facultad de Ciencias, Universidad de Granada, Granada, Spain
    J Exp Zool B Mol Dev Evol 312:734-48. 2009
    ..The fact that FST remains inactive during the critical stages of female gonad development, explains the lack of migration inhibition, and may be a consequence of improper WNT4 signalling in the mole...
  19. ncbi An investigation of the molecular basis of the spontaneous occurrence of a catalase-negative phenotype in Helicobacter pylori
    J Manos
    School of Microbiology and Immunology, University of New South Wales, Sydney, Australia
    Helicobacter 3:28-38. 1998
    ..pylori (UNSW-RU1) and sequenced katA in the parent strain and the promoters of both phenotypes as a prelude to understanding the genetic processes leading to the failure to express catalase.
  20. pmc Structure, dynamics, and branch migration of a DNA Holliday junction: a single-molecule fluorescence and modeling study
    Mikhail A Karymov
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, Nebraska 68198 6025, USA
    Biophys J 95:4372-83. 2008
    The Holliday junction (HJ) is a central intermediate of various genetic processes, including homologous and site-specific DNA recombination and DNA replication...
  21. pmc DNA polymorphism in recombining and non-recombining mating-type-specific loci of the smut fungus Microbotryum
    A A Votintseva
    Department of Plant Sciences, University of Oxford, Oxford, UK
    Heredity (Edinb) 106:936-44. 2011
    The population-genetic processes leading to the genetic degeneration of non-recombining regions have mainly been studied in animal and plant sex chromosomes...
  22. ncbi [Aging and carcinogenesis]
    V N Anisimov
    Department of Carcinogenesis and Oncogerontology, N N Petrov Research Institute of Oncology, Pesochny 2, St Petersburg 197758
    Adv Gerontol 10:99-125. 2002
    ..Some common genetic processes (e.g...
  23. pmc Genome-wide mutagenesis of Xanthomonas axonopodis pv. citri reveals novel genetic determinants and regulation mechanisms of biofilm formation
    Jinyun Li
    Department of Microbiology and Cell Science, Citrus Research and Education Center, University of Florida, Lake Alfred, Florida, United States of America
    PLoS ONE 6:e21804. 2011
    ..This work is the first report on a genome-wide scale of the genetic processes of biofilm formation in plant pathogenic bacteria...
  24. ncbi Putative DEAD and DExH-box RNA helicases families in Entamoeba histolytica
    Laurence A Marchat
    ENMH IPN, Programa Institucional de Biomedicina Molecular, Mexico DF, Mexico
    Gene 424:1-10. 2008
    RNA helicases catalyze the unwinding of double-stranded RNA structures to perform numerous genetic processes. These enzymes are characterized by the presence of a conserved helicase domain with specific helicases motifs whose amino acid ..
  25. ncbi The MAP kinase TVK1 regulates conidiation, hydrophobicity and the expression of genes encoding cell wall proteins in the fungus Trichoderma virens
    Artemio Mendoza-Mendoza
    Laboratorio Nacional de Genómica para la Biodiversidad, Centro de Investigacion y de Estudios Avanzados, Campus Guanajuato, Apartado Postal 629, 36500, Irapuato, Guanajuato, Mexico
    Microbiology 153:2137-47. 2007
    Mitogen-activated protein (MAP) kinases modulate morphological and genetic processes, which determine cell fate...
  26. ncbi The imprecision of heterozygosity-fitness correlations hinders the detection of inbreeding and inbreeding depression in a threatened species
    Catherine E Grueber
    Department of Zoology, University of Otago, Dunedin 9054, New Zealand
    Mol Ecol 20:67-79. 2011
    ..area has been performed on generally outbred, nonbottlenecked populations, but differences in population genetic processes may limit extrapolation of results to threatened populations...
  27. ncbi Dominant male sterility in sorghum: effect of nuclear background on inheritance of tissue-culture-induced mutation
    Lev A Elkonin
    Agricultural Research Institute for South East Region of Russia, 410010 Saratov, Russia
    Theor Appl Genet 111:1377-84. 2005
    Occurrence of genetic instability and formation of stable mutations are basic genetic processes. This study demonstrates that nuclear background may influence the formation of stable dominant nuclear gene of male sterility (MS) on the ..
  28. pmc Effect of single-strand break on branch migration and folding dynamics of Holliday junctions
    Dmytro Palets
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Biophys J 99:1916-24. 2010
    ..or four-way junction, is a central intermediate state of DNA for homologous genetic recombination and other genetic processes such as replication and repair...
  29. ncbi Glucuronidation in humans. Pharmacogenetic and developmental aspects
    S N de Wildt
    Department of Pediatrics, Erasmus University and University Hospital, Rotterdam, The Netherlands
    Clin Pharmacokinet 36:439-52. 1999
    ..of drug clearance is metabolism, something that is not only determined by ontogenic regulation but also by genetic processes which add to the variability of drug metabolism during different stages of childhood...
  30. ncbi Effects of population succession on demographic and genetic processes: predictions and tests in the daylily Hemerocallis thunbergii (Liliaceae)
    Mi Yoon Chung
    Department of Biology and Institute of Basic Science, Gyeongsang National University, Jinju 660 701, South Korea
    Mol Ecol 16:2816-29. 2007
    ..thunbergii populations across the landscape. This variation is generally consistent with succession-stage-specific differences in ecological processes operating within these populations...
  31. ncbi [Testing antineoplastic activity of new platinum(II) and palladium(II) complex compounds]
    Katarzyna Malinowska
    Uniwersytet Medyczny w Lodzi, Wydział Fizjoterapii, Zakład Chemii i Biochemii Klinicznej, Katedra Chemii i Biochemii Klinicznej
    Pol Merkur Lekarski 26:57-61. 2009
    A pyrazole system is incorporated in many biological molecules which play an important part in genetic processes. It seems that co-ordinating biological molecules, which would serve as carriers, should contribute to minimising the toxic ..
  32. ncbi 'DEAD-box' helicase from Plasmodium falciparum is active at wide pH and is schizont stage-specific
    Arun Pradhan
    Malaria Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
    J Vector Borne Dis 44:12-22. 2007
    DNA helicases catalyse unwinding of duplex DNA in an ATP-dependent manner and are involved in all the basic genetic processes. In order to study these important enzymes in the human malaria parasite we have recently cloned the first full-..
  33. ncbi Catalytic inhibitors of DNA topoisomerase II
    T Andoh
    Department of Bioengineering, Faculty of Engineering, Soka University, 1 236 Tangi cho, Hachioji, Tokyo 192 0003, Japan
    Biochim Biophys Acta 1400:155-71. 1998
    ..These compounds target the enzyme within the cell and inhibit various genetic processes involving the enzyme, such as DNA replication and chromosome dynamics, and thus proved to be good probes for ..
  34. ncbi The molecular biology of recombination in Mycobacteria: what do we know and how can we use it?
    D G Niranjala Muttucumaru
    Centre for Infectious Disease, Institute for Cell and Molecular Science, Barts and The London, Queen Mary s School of Medicine and Dentistry, Turner Street, London, E1 2AD, UK
    Curr Issues Mol Biol 6:145-57. 2004
    ..A recently developed method for studying essential genes will generate further insights into the biology of these important organisms...
  35. ncbi Heterozygosity-fitness correlations among wild populations of European tree frog (Hyla arborea) detect fixation load
    E Luquet
    Universite Lyon 1, CNRS UMR 5023 Ecologie des Hydrosystèmes Fluviaux, Universite Claude Bernard Lyon 1, Universite de Lyon, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne Cedex, France
    Mol Ecol 20:1877-87. 2011
    ..depression within populations and sometimes at the population level but without consideration about the genetic processes measured...
  36. pmc Single molecule fluorescence analysis of branch migration of holliday junctions: effect of DNA sequence
    Mikhail A Karymov
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198 6025, USA
    Biophys J 95:1239-47. 2008
    The Holliday junction is a central intermediate in various genetic processes including homologous, site-specific recombination and DNA replication...
  37. ncbi Weak founder effect signal in a recent introduction of Caribbean Anolis
    J Eales
    Environment Centre for Wales, School of Biological Sciences, College of Natural Sciences, Bangor University, Gwynedd LL57 2UW, UK
    Mol Ecol 17:1416-26. 2008
    Species introductions provide a rare opportunity to study rapid evolutionary and genetic processes in natural systems, often under novel environmental pressures...
  38. ncbi Pedigree parables
    R L Bennett
    Division of Medical Genetics, University of Washington, Seattle 98195 7720, USA
    Clin Genet 58:241-9. 2000
    ..At what point do such practices hinder the recognition of genetic processes? Is there evidence that harm has occurred to subjects who have appeared in published pedigrees? How does the ..
  39. pmc Maize as a model for the evolution of plant nuclear genomes
    B S Gaut
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697 2525, USA
    Proc Natl Acad Sci U S A 97:7008-15. 2000
    ..Population genetic processes also affect the evolution of genomes...
  40. pmc Genetic structures of copy number variants revealed by genotyping single sperm
    Minjie Luo
    Department of Molecular Genetics, Microbiology, and Immunology The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey, United States of America
    PLoS ONE 4:e5236. 2009
    ..However, because of the presence of their multiple copies, variability in copy numbers and the diploidy of the human genome, detailed genetic structure of CNVs cannot be readily studied by available techniques...
  41. ncbi Mass extinctions, biodiversity explosions and ecological niches
    Alain Pavé
    Laboratoire de biométrie et de biologie évolutive, UMR CNRS 5558, Universite Claude Bernard, Lyon 1, 69622 Villeurbanne, France
    C R Biol 325:755-65. 2002
    ..of ecological relationships, such as 'niche-sharing', which involves coexistence or cooperation), even if genetic processes must also be involved...
  42. ncbi Maximum likelihood estimates of species trees: how accuracy of phylogenetic inference depends upon the divergence history and sampling design
    John E McCormack
    Department of Ecology and Evolutionary Biology, and the Museum of Zoology, University of Michigan, Ann Arbor, MI 48109 1079, USA
    Syst Biol 58:501-8. 2009
    ..trees that contain them has led researchers to methods that incorporate the inherent stochasticity of genetic processes in the phylogenetic estimation procedure...
  43. pmc Phylogeographic history of grey wolves in Europe
    Małgorzata Pilot
    Museum and Institute of Zoology, Polish Academy of Sciences, 00 679 Warszawa, Poland
    BMC Evol Biol 10:104. 2010
    ..patterns of intra-specific genetic differentiation are substantially affected by glacial history, population genetic processes occurring during Pleistocene glaciations are still poorly understood...
  44. ncbi Colon Cancer Family Registry: an international resource for studies of the genetic epidemiology of colon cancer
    Polly A Newcomb
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 16:2331-43. 2007
    ..Family studies have served as a cornerstone of genetic research on colorectal cancer...
  45. pmc Regulation of secondary metabolism by chromatin structure and epigenetic codes
    Joseph Strauss
    Fungal Genetics and Genomics Unit, AIT Austrian Institute of Technology and BOKU University Vienna, Muthgasse 18, A 1190 Vienna, Austria
    Fungal Genet Biol 48:62-9. 2011
    Chromatin, composed of DNA wrapped around an octamer of histones, is the relevant substrate for all genetic processes in eukaryotic nuclei...
  46. pmc Mechanisms causing rapid and parallel losses of ribose catabolism in evolving populations of Escherichia coli B
    V S Cooper
    Center for Microbial Ecology, Michigan State University, East Lansing, Michigan 48824, USA
    J Bacteriol 183:2834-41. 2001
    ..We sought to identify the population genetic processes and molecular genetic events that caused these rapid and parallel losses...
  47. ncbi Interactions of protein complexes on supercoiled DNA: the mechanism of selective synapsis by Tn3 resolvase
    J Lesley Brown
    Institute of Biomedical and Life Sciences, University of Glasgow, 56 Dumbarton Road, Glasgow G11 6NU, Scotland, UK
    J Mol Biol 319:371-83. 2002
    ..interactions of distant sites on DNA molecules, mediated by DNA-binding proteins, feature in many regulated genetic processes. We used plasmids containing up to six res recombination sites for Tn3 resolvase to analyse looping ..
  48. ncbi Embryonic and larval development of the Drosophila mushroom bodies: concentric layer subdivisions and the role of fasciclin II
    Mitsuhiko Kurusu
    Institute of Biological Sciences, and Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba 305 8572, Japan
    Development 129:409-19. 2002
    ..In order to understand the cellular and genetic processes that control the early development of MBs, we have performed high-resolution neuroanatomical studies of the ..
  49. pmc Analysis of gene expression in response to water deficit of chickpea (Cicer arietinum L.) varieties differing in drought tolerance
    Deepti Jain
    National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi 110067, India
    BMC Plant Biol 10:24. 2010
    ..cultivated chickpea has a high morphological but narrow genetic diversity, and understanding the genetic processes of this plant is hindered by the fact that the chickpea genome has not yet been sequenced and its EST ..
  50. ncbi A human-derived reporter gene for noninvasive imaging in humans: mitochondrial thymidine kinase type 2
    Vladimir Ponomarev
    Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    J Nucl Med 48:819-26. 2007
    A human-derived intrinsically nonimmunogenic reporter gene was tested for PET imaging of different molecular-genetic processes for potential clinical use.
  51. pmc Abscisic acid-mediated epigenetic processes in plant development and stress responses
    Viswanathan Chinnusamy
    Water Technology Centre, Indian Agricultural Research Institute, New Delhi, India
    J Integr Plant Biol 50:1187-95. 2008
    ..Although ABA-regulated genetic processes are well known, recent discoveries reveal that epigenetic processes are an integral part of ABA-regulated ..
  52. ncbi Disentangling the effects of evolutionary, demographic, and environmental factors influencing genetic structure of natural populations: Atlantic herring as a case study
    Oscar E Gaggiotti
    Laboratoire d Ecologie Alpine, UMR CNRS 5553, Universite Joseph Fourier, 38041 Grenoble, France
    Evolution 63:2939-51. 2009
    ..Using a combination of such methods, we examined the roles of environment (i.e., natural selection), random genetic processes (i.e., drift), and demography and life histories (e.g...
  53. ncbi Integrating coalescent and ecological niche modeling in comparative phylogeography
    Bryan C Carstens
    Department of Ecology and Evolutionary Biology, Museum of Zoology, University of Michigan, Ann Arbor, MI 48109 1079, USA
    Evolution 61:1439-54. 2007
    ..phylogeographic research, but achieving this goal can be complicated by the stochastic variance inherent to genetic processes. Statistical approaches to testing phylogeographic hypotheses accommodate this stochasticity by evaluating ..
  54. ncbi Language as shaped by the brain
    Morten H Christiansen
    Department of Psychology, Cornell University, Ithaca, NY 14853, USA
    Behav Brain Sci 31:489-508; discussion 509-58. 2008
    ..UG have evolved? We argue that UG could not have arisen either by biological adaptation or non-adaptationist genetic processes, resulting in a logical problem of language evolution...
  55. ncbi [Genetic and epidemiological studies in Dagestan highland isolates]
    K B Bulaeva
    Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 117809 Russia
    Genetika 39:413-22. 2003
    ..The relationship between these interpopulation differences and the genetic processes that have been occurring in the populations throughout their history has been demonstrated...
  56. pmc The archaeal topoisomerase reverse gyrase is a helix-destabilizing protein that unwinds four-way DNA junctions
    Anna Valenti
    Institute of Protein Biochemistry, Consiglio Nazionale delle Ricerche, Via Pietro Castellino 111, 80131 Naples, Italy
    J Biol Chem 285:36532-41. 2010
    ..structures have important functional roles but may also severely interfere with DNA replication and other genetic processes; therefore, they are targeted by regulatory and architectural proteins, and dedicated pathways exist for ..
  57. ncbi Delimiting species without monophyletic gene trees
    L Lacey Knowles
    Department of Ecology and Evolutionary Biology, Museum of Zoology, University of Michigan, Ann Arbor, MI 48109 1079, USA
    Syst Biol 56:887-95. 2007
    ..from when and how speciation occurred, and failure to take into account the high stochastic variance of genetic processes. Both the utility and sensitivities of the coalescent-based approach outlined here are discussed; most ..
  58. ncbi Antibody diversification by somatic mutation: from Burnet onwards
    Michael S Neuberger
    1Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Immunol Cell Biol 86:124-32. 2008
    ..Work over the subsequent half-century substantiated Burnet's speculation, revealing two distinct novel genetic processes. During early development (when Burnet first thought the randomization took place) programmed gene segment ..
  59. ncbi Relevance of the deletion polymorphisms of the glutathione S-transferases GSTT1 and GSTM1 in pharmacology and toxicology
    H M Bolt
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Leibniz Research Centre for Working Environment and Human Factors, Dortmund, Germany
    Curr Drug Metab 7:613-28. 2006
    ..The structures of the GSTT and GSTM gene areas explain the underlying genetic processes. GSTT1-1 is highly conserved during evolution and plays a major role in phase-II biotransformation of a ..
  60. pmc The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions
    W F Dove
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706, USA
    Philos Trans R Soc Lond B Biol Sci 353:915-23. 1998
    ....
  61. ncbi HIV evolutionary dynamics within and among hosts
    Philippe Lemey
    Department of Zoology, University of Oxford, Oxford, UK
    AIDS Rev 8:125-40. 2006
    ..techniques have been developed to reconstruct the HIV evolutionary history and to investigate the population genetic processes that shape viral diversity...
  62. pmc Cushing syndrome caused by adrenocortical tumors and hyperplasias (corticotropin- independent Cushing syndrome)
    Constantine A Stratakis
    Section on Endocrinology and Genetics, Program on Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Endocr Dev 13:117-32. 2008
    ..adrenal disease and its pigmented variant, primary pigmented nodular adrenocortical disease are mostly genetic processes. Macronodular BAHs, ACTH-independent macronodular hyperplasia or massive macronodular adrenocortical disease ..
  63. ncbi DNA sequence-dependent variation in nucleosome structure, stability, and dynamics detected by a FRET-based analysis
    L Kelbauskas
    Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA
    Biochem Cell Biol 87:323-35. 2009
    ..Nucleosomes restrict regulatory factor access to DNA, thereby impeding genetic processes. Eukaryotic cells possess mechanisms to alter nucleosome structure, to generate DNA access, but alterations ..
  64. ncbi The emergence of major cellular processes in evolution
    C Ouzounis
    AI Center, SRI International, Menlo Park, CA 94025 3493, USA
    FEBS Lett 390:119-23. 1996
    ..In addition, genetic processes such as translation are conserved and close to the original form...
  65. ncbi Dynamics of attitudes and genetic processes
    Stephen J Guastello
    Department of Psychology, Marquette University, Milwaukee, WI 53201 1881, USA
    Nonlinear Dynamics Psychol Life Sci 12:75-86. 2008
    ..The linear model projected a gradual and continuing bifurcation between authoritarians and non-authoritarians. The nonlinear model projected a stabilization of authoritarian attitudes...
  66. ncbi Comparing performance by parents and offspring on a rapid tapping task
    ChungGon Kim
    School of Kinesiology University of Minnesota, Minneapolis, USA
    Percept Mot Skills 101:605-12. 2005
    ..This finding suggests that the potential of youngsters' future performance may be predicted with greater certainty by observing their parents' present performance. This may improve the predictive power of planned programs...
  67. ncbi Systems biology. Less is more in modeling large genetic networks
    Stefan Bornholdt
    Institute for Theoretical Physics, University of Bremen, Otto Hahn Allee, D 28359 Bremen, Germany
    Science 310:449-51. 2005
  68. ncbi A proteome-wide approach identifies sumoylated substrate proteins in yeast
    Vikram Govind Panse
    Biochemie Zentrum der Universitat Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany and Cellzome AG, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    J Biol Chem 279:41346-51. 2004
    ..Thus, the identification of a broad range of SUMO-1 substrate proteins is expected to lead to further insight into the regulatory aspects of sumoylation...
  69. ncbi Cell cycle checkpoints -- molecular background
    Barbara Grzelakowska-Sztabert
    Nencki Institute of Experimental Biology, Warszawa, Poland
    Folia Morphol (Warsz) 63:1-3. 2004
    ..The paper provides basic information about the molecular mechanisms operating in various cell cycle checkpoints activated by DNA damage or disturbances in mitotic spindle assembly...
  70. ncbi Using the Unified Modelling Language (UML) to guide the systemic description of biological processes and systems
    Magali Roux-Rouquié
    BSMI, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Biosystems 75:3-14. 2004
    ..This makes unambiguous representations of biological systems, which would be suitable for translation into mathematical and computational formalisms, enabling analysis, simulation and prediction of these systems behaviours...
  71. ncbi What's the difference
    Colin Berry
    QJM 96:953-4. 2003
  72. ncbi Epigenetic landscape for initiation of DNA replication
    Vladimir V Sherstyuk
    Russian Academy of Sciences, Siberian Branch, Institute of Cytology and Genetics, pr Akad Lavrentieva 10, Novosibirsk, 630090, Russia
    Chromosoma 123:183-99. 2014
    ..In the last few years, a number of different genome-wide studies have broadened the understanding of replication origin regulation. In this review, we discuss the epigenetic factors and mechanisms that modulate origin choice and firing. ..
  73. ncbi Corridors for migration between large subdivided populations, and the structured coalescent
    John Wakeley
    Department of Organismic and Evolutionary Biology, Harvard University, 2102 Biological Laboratories, Cambridge, MA 02138, USA
    Theor Popul Biol 70:412-20. 2006
    ..This justifies the application of a modified structured coalescent to some hierarchically structured populations...
  74. ncbi Determining when contamination is pollution - weight of evidence determinations for sediments and effluents
    Peter M Chapman
    Golder Associates, 195 Pemberton Avenue, North Vancouver, BC, Canada V7P 2R4
    Environ Int 33:492-501. 2007
    ..Effectively, a WOE assessment comprises an initial screening-level ecological risk assessment (ERA), which may be followed by a detailed-level ERA if key uncertainties need to be resolved...
  75. ncbi Construction of a high-density composite map and comparative mapping of segregation distortion regions in barley
    Haobing Li
    Tasmanian Institute of Agricultural Research and School of Agricultural Science, University of Tasmania, Private Bag 54, Hobart, TAS, 7001, Australia
    Mol Genet Genomics 284:319-31. 2010
    ..Six of the seven centromeric regions harboured SDRs suggesting that genetic processes related to position near a centromere caused the segregation distortion in these SDRs...
  76. ncbi [Endometriosis]
    László Lampé
    Debreceni Egyetem, Orvos és Egészségtudományi Centrum, Általános Orvostudományi Kar, Szülészeti és Nőgyógyászati Klinika, Debrecen
    Orv Hetil 150:245-50. 2009
    ..adenomyosis), retrograde menstruation, embolisation, metaplasia together with defective immunological and genetic processes have all been confirmed as possible mechanisms of the development of disease...
  77. pmc A role for Snf2-related nucleosome-spacing enzymes in genome-wide nucleosome organization
    Triantaffyllos Gkikopoulos
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    Science 333:1758-60. 2011
    ..This organization is likely to influence many genetic processes, requiring access to the underlying DNA...
  78. pmc How DNA coiling enhances target localization by proteins
    B van den Broek
    Department of Physics and Astronomy, Faculty of Sciences, Vrije Universiteit, De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 105:15738-42. 2008
    Many genetic processes depend on proteins interacting with specific sequences on DNA. Despite the large excess of nonspecific DNA in the cell, proteins can locate their targets rapidly...
  79. ncbi Colored petri nets to model gene mutation and amino acids classification
    Jinliang Yang
    School of Control Science and Engineering, Shandong University, Jinan, Shandong Province 250061, China
    J Theor Biol 300:183-92. 2012
    ..Choosing an appropriate model for processing these codons is a useful method to study genetic processes in Molecular Biology...
  80. ncbi Molecular biology of sporadic gastric cancer: prognostic indicators and novel therapeutic approaches
    Mario Scartozzi
    Clinica di Oncologia Medica, Università Politecnica delle Marche Azienda Ospedaliera Umberto I, Ancona, Italy
    Cancer Treat Rev 30:451-9. 2004
    ..e., thymidilate synthase that is targeted by 5FU) or to a new class of antineoplastic molecules (i.e., c-erb B-2 targeted by trastuzumab, COX-2 by NSAIDs, matrix metalloproteinases, EGFR and VEGFR by specific inhibitors)...
  81. pmc Functional imaging techniques for evaluation of sarcomas
    Rodney J Hicks
    The Centre for Molecular Imaging, The Peter MacCallum Cancer Centre, Melbourne, Australia
    Cancer Imaging 5:58-65. 2005
    ..This heterogeneity reflects physiologic, biochemical and genetic processes that are amenable to characterisation by functional imaging...
  82. ncbi Seed-mediated connectivity among fragmented populations of Quercus castanea (Fagaceae) in a Mexican landscape
    M Luisa Herrera-Arroyo
    Centro de Investigaciones en Ecosistemas Universidad Nacional Autónoma de México UNAM, Antigua Carretera a Pátzcuaro No 8701, Col Ex Hacienda San José de la Huerta, Morelia 58190 Michoacán, Mexico
    Am J Bot 100:1663-71. 2013
    ..may create loss of connectivity among tree populations and constitutes a serious threat to ecological and genetic processes. We tested the central hypothesis that seed dispersal mitigates the impact of fragmentation by comparing ..
  83. ncbi CAVEman: Standardized anatomical context for biomedical data mapping
    Andrei L Turinsky
    Sun Center of Excellence for Visual Genomics, University of Calgary, Calgary, Alberta, Canada
    Anat Sci Educ 1:10-8. 2008
    ..The CAVEman system is now used to visualize genetic processes in the context of the human anatomy and to facilitate visual exploration of the data...
  84. ncbi Chronic cocaine causes long-term alterations in circadian period and photic entrainment in the mouse
    A C Stowie
    Department of Biological Sciences, Kent State University, Kent, OH 44242, USA
    Neuroscience 284:171-9. 2015
    The disruptive effects of cocaine on physiological, behavioral and genetic processes are well established...
  85. ncbi An overview of the utility of population simulation software in molecular ecology
    Sean Hoban
    National Institute for Mathematical and Biological Synthesis, University of Tennessee, 1122 Volunteer Blvd, Suite 110A Knoxville, TN, 37996 3410, USA
    Mol Ecol 23:2383-401. 2014
    ..demographic-genetic simulation software, especially with respect to individual life history, landscapes and genetic processes, are transforming and expanding the ways that molecular data can be used...
  86. ncbi MtDNA ancestry of Rio de Janeiro population, Brazil
    Suellen Bernardo
    Laboratório de Diagnósticos por DNA, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
    Mol Biol Rep 41:1945-50. 2014
    ..The high proportion of African mtDNA lineages in the population of Rio de Janeiro is in accordance with studies related to other Brazilian states...
  87. pmc The emerging roles of eRNAs in transcriptional regulatory networks
    Kambiz Mousavi
    Moderna Therapeutics Inc Cambridge, MA USA
    RNA Biol 11:106-10. 2014
    ..Critical to our understanding of genetic processes is the mechanism by which ncRNAs exert their roles...
  88. pmc Population-genetic influences on genomic estimates of the inbreeding coefficient: a global perspective
    Trevor J Pemberton
    Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Man, Canada
    Hum Hered 77:37-48. 2014
    Culturally driven marital practices provide a key instance of an interaction between social and genetic processes in shaping patterns of human genetic variation, producing, for example, increased identity by descent through ..
  89. ncbi Cytoplasmic localization and reorganization in ascidian eggs: role of postplasmic/PEM RNAs in axis formation and fate determination
    Kazuhiro W Makabe
    Institute of Socio Arts and Sciences, University of Tokushima, Tokushima, Japan
    Wiley Interdiscip Rev Dev Biol 1:501-18. 2012
    ..eggs and embryos and cytoplasmic movements to relocalize them are fundamental for the orderly cellular and genetic processes during early embryogenesis...
  90. pmc The elusive object of desire--interactions of bacteriophages and their hosts
    Sergei Nechaev
    Laboratory of Molecular Carcinogenesis, NIEHS NIH, Room D434, 111 Alexander Dr, Research Triangle Park, NC 27709, USA
    Curr Opin Microbiol 11:186-93. 2008
    ..As a result, phages play central roles in a great variety of genetic processes and increase the rate of evolutionary change of the bacterial host, which could ultimately work to the ..
  91. ncbi Induced mutations in yeast cell populations adapting to an unforeseen challenge
    Lindsay S Moore
    Department of Physics and Network Biology Research Laboratories, Technion Israel Institute of Technology, Haifa, Israel
    PLoS ONE 9:e111133. 2014
    ..Our results demonstrate the existence of adaptation mechanisms beyond random mutation, suggesting a tight connection between physiological and genetic processes.
  92. ncbi Large-scale chromatin remodeling at the immunoglobulin heavy chain locus: a paradigm for multigene regulation
    Daniel J Bolland
    Laboratory of Chromatin and Gene Expression, Babraham Institute, Babraham Research Campus, Cambridge, UK
    Adv Exp Med Biol 650:59-72. 2009
    ..the largest multigene loci in the mammalian genome and V(D)J recombination is one of the most complicated genetic processes in the nucleus...
  93. ncbi Targeted therapy in GIST: in silico modeling for prediction of resistance
    Marco A Pierotti
    Fondazione IRCCS Istituto Nazionale dei Tumori Milano, Via Venezian 1, 20133 Milano, Italy
    Nat Rev Clin Oncol 8:161-70. 2011
    Elucidation of the genetic processes leading to neoplastic transformation has identified cancer-promoting molecular alterations that can be selectively targeted by rationally designed therapeutic agents...
  94. ncbi Mass fluctuation kinetics: analysis and computation of equilibria and local dynamics
    P Azunre
    Massachusetts Institute of Technology, EECS Department, Room 13 3029, Cambridge, USA
    IET Syst Biol 5:325-35. 2011
    ..Moreover, our analysis provides evidence that decreasing volume from the MAK regime (infinite volume) has a destabilising effect on system dynamics...
  95. ncbi The need for a behavioural science focus in research on mental health and mental disorders
    Hans Ulrich Wittchen
    Institute of Clinical Psychology and Psychotherapy, Center for Clinical Epidemiology and Longitudinal Studies CELOS, Technische Universitat Dresden, Dresden, Germany
    Int J Methods Psychiatr Res 23:28-40. 2014
    ..result of developmental dysfunctions of psychological functions and processes as well as neurobiological and genetic processes that interact with the environment...
  96. ncbi Effects of genomic imprinting on quantitative traits
    Hamish G Spencer
    National Research Centre for Growth and Development and Allan Wilson Centre for Molecular Ecology and Evolution, Department of Zoology, University of Otago, P O Box 56, Dunedin, 9054, New Zealand
    Genetica 136:285-93. 2009
    Standard Mendelian genetic processes incorporate several symmetries, one of which is that the level of expression of a gene inherited from an organism's mother is identical to the level should that gene have been inherited paternally...
  97. ncbi Genomics and autism spectrum disorder
    Norah L Johnson
    Marquette University College of Nursing, Milwaukee, WI 53201, USA
    J Nurs Scholarsh 45:69-78. 2013
    ....
  98. pmc Effects of genetic drift and gene flow on the selective maintenance of genetic variation
    Bastiaan Star
    Centre for Ecological and Evolutionary Synthesis CEES, Department of Biosciences, University of Oslo, N 0316 Oslo, Norway
    Genetics 194:235-44. 2013
    ..for the genetic variation ubiquitous in natural populations are often classified by the population-genetic processes they emphasize: natural selection or mutation and genetic drift...
  99. ncbi Intraclonal heterogeneity in concomitant monoclonal lymphocyte and plasma cell populations: combining flow cytometric cell sorting with molecular monoclonality profiling
    Barbara K Zehentner
    HematoLogics, Inc, Seattle, WA, USA
    Clin Lymphoma Myeloma Leuk 13:214-7. 2013
    ..Our findings demonstrated that related genetic processes are less likely than unrelated genetic processes...
  100. pmc From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later
    Valerie Barbe
    CEA, Institut de Génomique, Genoscope, 2 rue Gaston Cremieux, 91057 Evry, France
    Microbiology 155:1758-75. 2009
    ..subtilis is an epiphyte). This should permit investigators to make reliable inferences to prepare validation experiments in a variety of domains of bacterial growth and development as well as build up accurate phylogenies...
  101. ncbi Human development: biological and genetic processes
    Irving I Gottesman
    Department of Psychiatry and Department of Psychology, University of Minnesota, Minneapolis, MN 55454, USA
    Annu Rev Psychol 56:263-86. 2005
    ..For human behavioral disorders such as schizophrenia and autism, the inherent plasticity of the nervous system requires a systems approach to incorporate all of the myriad epigenetic factors that can influence such outcomes...

Research Grants61

  1. Mechanisms for the evolution of novel DNA specificity in a transcription factor f
    Joseph W Thornton; Fiscal Year: 2013
    ..The resulting structure-function knowledge will facilitate efforts to engineer TFs with new DNA-binding specificities in synthetic biology and biomedicine. ..
  2. PHENOGENETICS OF SKULL AND BRAIN INTEGRATION IN CRANIOSYNOSTOSIS
    JOAN THERESE RICHTSMEIER; Fiscal Year: 2012
    ..Ours is a "phenogenetic" approach that attempts to connect biological phenotypes with their underlying genetic processes such as regional differentiation by activation of signaling...
  3. Poly ADP-ribose Polymerase in Chromatin and Transcriptional Regulation
    Alexei V Tulin; Fiscal Year: 2012
    ..Statement: Understanding how an organism can utilize PARP protein ability to modulate chromatin and transcription will provide fundamental insight into genetic processes that are essential for growth, development, and pathogenesis.
  4. Nicotine Addiction: Learning, Neural &Genetic Process
    Thomas J Gould; Fiscal Year: 2013
    ....
  5. Genomic Patterns of Polymorphism in Primates
    Jeffrey D Wall; Fiscal Year: 2012
    ..A major goal is to infer the relative influence of a number of population genetic processes that differentially affect the X chromosome versus autosomes, such as changes in population size and sex-..
  6. Summer Undergraduate Research Program in Molecular and Developmental Neurobiology
    Mladen Roko Rasin; Fiscal Year: 2013
    ..The multidisciplinary research focus of the other faculty mentors on the cellular, molecular, and genetic processes underlying developmental and degeneration of the nervous system also has implications for the etiology, ..
  7. MODELS OF COMPLEX GENETIC SYSTEMS
    MONTGOMERY WILSON SLATKIN; Fiscal Year: 2012
    ..research will be intended to help analyze and interpret DNA sequence data both for understanding basic genetic processes such as natural selection and recombination and for understanding the history of humans and the genetic ..
  8. Program on Molecular and Cellular Mechanisms of Tumorigenesis
    Jef D Boeke; Fiscal Year: 2010
    ..to an understanding of the molecular mechanisms responsible for cancer by investigating fundamental genetic processes involved in the control of cell growth and the maintenance of genomic stability...
  9. RESTMD-CHARMM simulation of the Chk2/PP2A interaction in DNA repair
    SHANADEEN C BEGAY; Fiscal Year: 2011
    ..This research will advance cancer care by providing unprecedented insights into the fundamental genetic processes and determinants of breast cancer susceptibility.
  10. Fine-scale recombination rate variation within and between Drosophila species
    MOHAMED A NOOR; Fiscal Year: 2010
    ..are where does the biologically relevant variation reside and what are the structural, evolutionary, and genetic processes shaping this variation? Meiotic recombination lies at the nexus of these two questions...
  11. Using whole genomes to study demography and mapping power of a population isolate
    CHARLESTON CHIANG; Fiscal Year: 2013
    ..Notably, our framework will not only help us understand the history of Sardinia, but can also be extended to other outbred and potentially diverse populations as these datasets become available. ..
  12. Utilizing a novel liquid-killing assay to gain insight into C. elegans immunity
    Natalia V Kirienko; Fiscal Year: 2013
    ..In addition, these compounds are likely to prove a more difficult target for the adaptive genetic processes of microbes, as they unbalance the host-pathogen interaction, rather than simply killing the pathogen or ..
  13. Culture, Mind and Brain: Neural Plasticity and Development in Social Context
    Shinobu Kitayama; Fiscal Year: 2010
    ..patterning of behavior through social structures, beliefs, and practices) influence biology (for example, genetic processes, brain functioning), and conversely, biology influences culture, with both mutual influences considered over ..
  14. MATRIX ATTACHMENT REGIONS IN AN IMPRINTED DOMAIN
    John Greally; Fiscal Year: 2001
    ....
  15. FACTORS REGULATING TRANSPOSITION IN C. ELEGANS
    John Collins; Fiscal Year: 1992
    ..These results will be compared with available data for Tc1, providing important information about the extent to which these different element families might respond to the same transposases...
  16. Evolutionary Genomics of Supersized Mitochondrial Genomes
    ANDREW ALVERSON; Fiscal Year: 2009
    ..A recent study proposed that similar population genetic processes govern the evolution of nuclear and organellar genome size and concluded that the disparity in mitochondrial ..
  17. INBORN ERRORS OF A PURINE SALVAGE PATHWAY
    Jay Tischfield; Fiscal Year: 2000
    ..A study of DHA-induced gene expression in cultured kidney epithelial cells and whole kidneys is aimed at understanding molecular genetic processes that lead to nephrolithiasis and kidney failure.
  18. Predoctoral Training Program in Genetic Mechanisms
    James W Gober; Fiscal Year: 2011
    ..Its rationale is based on the continuing need for research into fundamental genetic processes such as the mechanisms of gene regulation, genetic recombination and transfer, DMA damage and repair, ..
  19. Human HMGN proteins: role in chromatin & gene function
    Barbara Rattner; Fiscal Year: 2007
    Chromatin is the physiologically relevant substrate for all genetic processes inside eukaryotic nuclei...
  20. PROSPECTIVE PREDICTORS OF BIPOLAR DISORDERS
    Laura Sanchez; Fiscal Year: 2002
    ..that developmental dysfunction in fronto-subcortical neural networks mediating emotional processes may play in the pathogenesis of affective illness and the genetic and non-genetic processes that might contribute to such disturbances.
  21. Functional Genomics of Cryptosporidium parvum
    Giovanni Widmer; Fiscal Year: 2007
    ..will take advantage of the genomic sequence by converting genomic information into a tool for identifying genetic processes associated with parasite development...
  22. GENETICS OF DNA REPLICATION IN BACTERIA
    Russell Maurer; Fiscal Year: 1990
    ....
  23. MAGNETIC FIELD EFFECTS ON MACROPHAGES
    Joseph Brain; Fiscal Year: 1991
    ..weakly with magnetic fields, and the direct effects of magnetic fields on cellular, biochemical, and genetic processes have not been reproducibly established...
  24. VERTEBRATE MIDBRAIN AND LIMB DEVELOPMENT
    Randy Johnson; Fiscal Year: 2001
    ..generated as a result of this work will facilitate future endeavors aimed at defining specific molecular genetic processes which underlie the acquisition of shape and form during animal embryogenesis...
  25. PILIN GENES OF EIKENELLA CORRODENS
    Rona Hirschberg; Fiscal Year: 1993
    ..corrodens pilin gene(s), and to determine whether pilin gene expression undergoes phase variation. Biochemical, molecular genetic and immunological approaches will be used to address these issues...
  26. CLINICAL TRIALS OF A GENETICALLY ENGINEERED HCMV
    George Kemble; Fiscal Year: 1999
    ..They successfully developed molecular genetic processes to engineer HCMV...
  27. AREA: Translational Roles of the Ribosomal E site
    James Curran; Fiscal Year: 2009
    ..Second, this work will contribute to the research environment at Wake Forest University. Finally, it will contribute to the research training of BS- and MS-level students who are destined for biomedical careers. ..
  28. Math5 Regulatory Pathway in Retinal Development
    Lin Gan; Fiscal Year: 2010
    ..Studies to identify genes and genetic processes essential for the formation of retinal neurons will provide the foundation for retinal regeneration...
  29. Salmonella Gene Expression in Complex Environments
    Michael McClelland; Fiscal Year: 2004
    ..What are the genetic processes that underlie the interaction of a pathogen with commensal or symbiotic microbiota? These are difficult ..
  30. MOLECULAR BASIS OF SNELL DWARF AND LITTLE LONGEVITY
    John Papaconstantinou; Fiscal Year: 2003
    ..dwarf mutants are strikingly similar, these mice provide an excellent resource to study the molecular and genetic processes that determine longevity in vertebrates...
  31. DISEASE ON NEW HOSTS: MICROBOTRYUM AS A MODEL SYSTEM
    Janis Antonovics; Fiscal Year: 2002
    ..predictive approach to the study of host shifts and to attain a basic understanding of the ecological and genetic processes involved...
  32. NUCLEIC ACID CONFORMATION, PROPERTIES, AND INTERACTIONS
    WILMA OLSON; Fiscal Year: 2006
    ..interests focus on ligand-induced distortions of B-DNA important to its manipulation and control during genetic processes: (1) the transitions of B-DNA to three closely related helical formsuA-DNA, which is implicated in enzymatic ..
  33. Epigenetic modifications during hematopoiesis
    Michael Litt; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): All genetic processes within the nuclei of a eukaryotic cell occur in the context chromatin...
  34. Variation of D. melanogaster chromosome 4
    Manyuan Long; Fiscal Year: 2006
    ..These studies should add significantly to the understanding of the evolutionary genetics of the Drosophila fourth chromosome. ..
  35. RNA STRUCTURE DURING TRYPANOSOMATID EDITING
    GREGORY CONNELL; Fiscal Year: 2001
    ..More than 30 million people in the tropics and subtropics suffer from the diseases caused by these parasites. ..
  36. GENES FOR VASCULAR MORPHOGENESIS: A GENETIC APPROACH
    Qing Wang; Fiscal Year: 2003
    ..We use the human genetic approach as the window into the genetic processes involved in the development of the heart and blood vessels...
  37. Hormonal and cell-specific regulation of Dmrt1
    LESLIE HECKERT; Fiscal Year: 2006
    ..suggests that identification of factors acting upstream and downstream of it will provide insight into the genetic processes that regulate gene expression in the testis and enhance our understanding of the molecular events necessary ..
  38. A New CT System for Small-Animal Imaging
    MARTIN CLAJUS; Fiscal Year: 2009
    ..other hand, small animal imaging involves non- invasive imaging techniques that enable molecular targets and genetic processes to be visualized and measured in living laboratory animals...
  39. Brn-3 Transcription Factors in Retinal Development
    Lin Gan; Fiscal Year: 2007
    ..Currently, the effective cures and prevention methods remain elusive. Identification of genes and genetic processes important for the formation and survival of retinal neurons will lead to the development of prevention drugs ..
  40. TRAINING IN BEHAVIORAL NEUROSCIENCE
    Michael Fanselow; Fiscal Year: 2009
    We believe that the greatest progress toward understanding neural and genetic processes that contribute to normal and abnormal behavior, cognition and emotion will occur in a context where expertise in neuroscience goes hand in hand ..
  41. Doppler characterization of embryonic mouse circulation
    Colin Phoon; Fiscal Year: 2005
    ..provided by applicant) Recent advances in molecular cardiology have provided much insight into the genetic processes involved in normal heart development...
  42. MITOCHONDRIAL DNA OF NORMAL AND MUTANT TRYPANOSOMES
    Kenneth Stuart; Fiscal Year: 2001
    ..These studies are intended increase our understanding of basic molecular genetic processes, especially those which are important to the survival of parasites.
  43. HOMEBOX GENES IN CARDIAC DEVELOPMENT AND FUNCTION
    Michael Kern; Fiscal Year: 2001
    ..Understanding the genetic processes of heart development and function will enhance future treatments for cardiac pathologies...
  44. Higher-Order Protein-DNA Complexes in Gene Regulation
    Kenneth Zaret; Fiscal Year: 2005
    ..how chromatin structure is modified during the earliest stages of gene regulation will provide fundamental insight into genetic processes that are essential for growth, development, and pathogenesis in humans.
  45. Determinants of Behavior Problems after Divorce
    BRIAN D ONOFRIO; Fiscal Year: 2003
    ..abstract_text> ..
  46. Role of the BCR in B lymphocyte survival and development
    John Monroe; Fiscal Year: 2002
    ....
  47. Full polarization characterization by OCT
    Lihong Wang; Fiscal Year: 2006
    ..Analyze and characterize the temporal healing process of burns in the animal model. ..
  48. LEPTIN, IGFS AND COLORECTAL ADENOMA CANCER RISK
    Polly Newcomb; Fiscal Year: 2005
    ..This study may provide insights into the biologic mechanisms whereby obesity is associated with colorectal cancer risk, as well as have practical implications for cancer prevention. ..
  49. A Twin Study of Cognitive Outcomes in Older Adult Cancer
    Margaret Gatz; Fiscal Year: 2006
    ..Through abstracting data from cancer treatment records and linking them to existing datasets, we will be able to examine possible longer term effects, along with likely covariates, with optimal comparison groups. ..
  50. Cell Sorting and Molecular Analysis for Minimal Disease Detection
    Barbara Zehentner; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  51. Effects of Stress and Adrenal Functioning on Cognition
    JILL MATEO; Fiscal Year: 2006
    ....
  52. MDS Nordian Gammacell-40 Exactor Whole Animal Irradiator
    John Monroe; Fiscal Year: 2002
    ..abstract_text> ..
  53. Medications, Genetic Variability & Breast Cancer
    Polly Newcomb; Fiscal Year: 2007
    ..abstract_text> ..
  54. BIODEMOGRAPHY OF GENETIC DISEASE
    BRUCE CARNES; Fiscal Year: 2003
    ..The results derived from this award will have relevance for the estimation of lower limits to age-specific death rates, upper limits to human longevity, and forecasting life expectancy and the size of the older population. ..
  55. DEMENTIA IN SWEDISH TWINS
    Margaret Gatz; Fiscal Year: 2002
    ..Different diagnostic criteria will be compared. Quantitative indices will be derived from neuropsychological scores and from neuroimaging data subjected to quantitative mapping. ..
  56. Dementia in Swedish Twins Data Archiving
    Margaret Gatz; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  57. Colon Cancer Pathways: Hyperplastic Polyps and Adenomas
    Polly Newcomb; Fiscal Year: 2009
    ..The results of this study will have implications for understanding the biology and prevention of colorectal cancer. ..
  58. Colon Cancer Risk: IGF Polymorphisms/Lifestyle Factors
    Polly Newcomb; Fiscal Year: 2003
    ..As an adjunct to an existing study, this is an efficient, valid cost-effective approach to the investigation of the association between polymorphisms and cancer risk. ..
  59. Intrinsic and extrinsic control of B cells tolerance
    John Monroe; Fiscal Year: 2004
    ..abstract_text> ..
  60. Hormones and Colon Cancer: Epigenetic Subtypes, Risk, and Survival
    Polly Newcomb; Fiscal Year: 2009
    ....
  61. FULL-FIELD MUELLER-MATRIX TOMOGRAPHY
    Lihong Wang; Fiscal Year: 2001
    ..The proposed technology will potentially find broad applications in medical diagnostics for superficial lesions such as ocular, skin, and cervical lesions. ..