Top Publications

  1. ncbi Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis
    Michael F Holick
    Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118 2394, USA
    Am J Clin Nutr 79:362-71. 2004
  2. ncbi DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27
    Hekla Sigmundsdottir
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 8:285-93. 2007
  3. ncbi Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety
    R Vieth
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Mount Sinai Hospital, Ontario, Canada
    Am J Clin Nutr 69:842-56. 1999
  4. ncbi Benefits and requirements of vitamin D for optimal health: a review
    William B Grant
    Sunlight Nutrition and Health Research Center SUNARC, 2107 Van Ness Ave, Ste 403B, San Francisco, CA 94109, USA
    Altern Med Rev 10:94-111. 2005
  5. ncbi Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure
    Sara Gandini
    Department of Epidemiology and Biostatistics, European Institute of Oncology, IRCCS Via Ripamonti 435, 20141 Milan, Italy
    Eur J Cancer 41:45-60. 2005
  6. ncbi Epidemiology of melanoma and nonmelanoma skin cancer--the role of sunlight
    Ulrike Leiter
    Division of Dermatoloncology, Department of Dermatology, University Medical Center, University of Tuebingen, Liebermeisterstr, 25, 72076 Tuebingen, Germany
    Adv Exp Med Biol 624:89-103. 2008
  7. ncbi Vitamin D deficiency: a global perspective
    Ann Prentice
    The Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom and Medical Research Council Keneba, Keneba, The Gambia
    Nutr Rev 66:S153-64. 2008
  8. ncbi High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India
    Alok Sachan
    Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Am J Clin Nutr 81:1060-4. 2005
  9. ncbi From sunlight to phytomass: on the potential efficiency of converting solar radiation to phyto-energy
    Jeffrey S Amthor
    Faculty of Agriculture, Food and Natural Resources C81, University of Sydney, NSW 2006, Australia
    New Phytol 188:939-59. 2010
  10. ncbi Cancer survival is dependent on season of diagnosis and sunlight exposure
    Hyun Sook Lim
    King s College London, Thames Cancer Registry, London, United Kingdom
    Int J Cancer 119:1530-6. 2006

Detail Information

Publications306 found, 100 shown here

  1. ncbi Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis
    Michael F Holick
    Vitamin D, Skin, and Bone Research Laboratory, Section of Endocrinology, Diabetes, and Nutrition, Department of Medicine, Boston University School of Medicine, Boston, MA 02118 2394, USA
    Am J Clin Nutr 79:362-71. 2004
    ..Numerous epidemiologic studies suggest that exposure to sunlight, which enhances the production of vitamin D(3) in the skin, is important in preventing many chronic diseases...
  2. ncbi DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27
    Hekla Sigmundsdottir
    Laboratory of Immunology and Vascular Biology, Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA
    Nat Immunol 8:285-93. 2007
    ..Our findings support a model in which dendritic cells process and 'interpret' locally produced metabolites to 'program' T cell homing and microenvironmental positioning...
  3. ncbi Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety
    R Vieth
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Mount Sinai Hospital, Ontario, Canada
    Am J Clin Nutr 69:842-56. 1999
    ..adults, the 5-microg (200 IU) vitamin D recommended dietary allowance may prevent osteomalacia in the absence of sunlight, but more is needed to help prevent osteoporosis and secondary hyperparathyroidism...
  4. ncbi Benefits and requirements of vitamin D for optimal health: a review
    William B Grant
    Sunlight Nutrition and Health Research Center SUNARC, 2107 Van Ness Ave, Ste 403B, San Francisco, CA 94109, USA
    Altern Med Rev 10:94-111. 2005
    ..In the absence of adequate solar UVB irradiation due to season, latitude, or lifestyle, vitamin D can be obtained from fortified food, oily fish, vitamin D supplements, and artificial sources of UVB radiation...
  5. ncbi Meta-analysis of risk factors for cutaneous melanoma: II. Sun exposure
    Sara Gandini
    Department of Epidemiology and Biostatistics, European Institute of Oncology, IRCCS Via Ripamonti 435, 20141 Milan, Italy
    Eur J Cancer 41:45-60. 2005
  6. ncbi Epidemiology of melanoma and nonmelanoma skin cancer--the role of sunlight
    Ulrike Leiter
    Division of Dermatoloncology, Department of Dermatology, University Medical Center, University of Tuebingen, Liebermeisterstr, 25, 72076 Tuebingen, Germany
    Adv Exp Med Biol 624:89-103. 2008
    ..the hypothesis that the majority of all melanoma cases are caused, at least in part, by excessive exposure to sunlight. In contrast to squamous cell carcinoma, melanoma risk seems not to be associated with cumulative, but ..
  7. ncbi Vitamin D deficiency: a global perspective
    Ann Prentice
    The Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom and Medical Research Council Keneba, Keneba, The Gambia
    Nutr Rev 66:S153-64. 2008
    ..There is an urgent need for action to address the global burden of rickets and osteomalacia...
  8. ncbi High prevalence of vitamin D deficiency among pregnant women and their newborns in northern India
    Alok Sachan
    Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
    Am J Clin Nutr 81:1060-4. 2005
    ..Vitamin D deficiency during pregnancy has important implications for the newborn and infant. There are few data from India about the prevalence of hypovitaminosis D in pregnancy and in the newborn...
  9. ncbi From sunlight to phytomass: on the potential efficiency of converting solar radiation to phyto-energy
    Jeffrey S Amthor
    Faculty of Agriculture, Food and Natural Resources C81, University of Sydney, NSW 2006, Australia
    New Phytol 188:939-59. 2010
    ..Field-based data indicate that exceptional crops may attain a significant fraction of potential efficiency...
  10. ncbi Cancer survival is dependent on season of diagnosis and sunlight exposure
    Hyun Sook Lim
    King s College London, Thames Cancer Registry, London, United Kingdom
    Int J Cancer 119:1530-6. 2006
    b>Sunlight is essential for the production of vitamin D in the body. Evidence exists to suggest that vitamin D metabolites may have a role in tumor growth suppression...
  11. ncbi Sunlight and dietary contributions to the seasonal vitamin D status of cohorts of healthy postmenopausal women living at northerly latitudes: a major cause for concern?
    H M Macdonald
    University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Osteoporos Int 22:2461-72. 2011
    We assessed sunlight and dietary contributions to vitamin D status in British postmenopausal women...
  12. ncbi Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease
    Michael F Holick
    Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin, and Bone Research Laboratory, Boston University Medical Center, Boston, MA 02118, USA
    Am J Clin Nutr 80:1678S-88S. 2004
    ..Although chronic excessive exposure to sunlight increases the risk of nonmelanoma skin cancer, the avoidance of all direct sun exposure increases the risk of ..
  13. ncbi Low vitamin D status despite abundant sun exposure
    N Binkley
    University of Wisconsin Osteoporosis Research Program, Madison, WI 53705, USA
    J Clin Endocrinol Metab 92:2130-5. 2007
    ..However, some individuals with seemingly adequate UV exposure have been reported to have low serum 25-hydroxyvitamin D [25(OH)D] concentration, results that might have been confounded by imprecision of the assays used...
  14. ncbi Skin cancer and solar UV radiation
    F R de Gruijl
    Department of Dermatology, University Medical Centre Utrecht, The Netherlands
    Eur J Cancer 35:2003-9. 1999
    Ultraviolet (UV) radiation in sunlight is the most prominent and ubiquitous physical carcinogen in our natural environment. It is highly genotoxic but does not penetrate the body any deeper than the skin...
  15. ncbi Measures of sun exposure and sun protection practices for behavioral and epidemiologic research
    Karen Glanz
    Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Room 530, Atlanta, GA 30322, USA
    Arch Dermatol 144:217-22. 2008
    ..To develop, in a collaborative project, core measures of sun exposure and sun protection habits, since the lack of standard outcome measures hampers comparison of population surveys and interventions used in skin cancer prevention research...
  16. ncbi Risk factors for skin cancers: a nested case-control study within the Nurses' Health Study
    Jiali Han
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Int J Epidemiol 35:1514-21. 2006
    ..Constitutional factors and sun exposure are associated with skin cancer risk. However, these relations are complex and differ according to skin cancer type...
  17. ncbi Global vitamin D levels in relation to age, gender, skin pigmentation and latitude: an ecologic meta-regression analysis
    T Hagenau
    Department of Endocrinology and Metabolism C, Aarhus Amtssygehus, Aarhus University Hospital, Aarhus, Denmark
    Osteoporos Int 20:133-40. 2009
    ..Serum 25(OH)D levels on average were 54 nmol/l, were higher in women than men, and higher in Caucasians than in non-Caucasians. There was no trend in serum 25(OH)D level with latitude. Vitamin D deficiency was widespread...
  18. ncbi 25-Hydroxyvitamin D levels in serum at the onset of multiple sclerosis
    M Soilu-Hanninen
    MediCity Research Laboratory, University of Turku, Tykistokatu 6, FIN 20520 Turku, Finland
    Mult Scler 11:266-71. 2005
    ..The optimal serum levels of vitamin D for the regulation of immune responses remain to be determined...
  19. pmc Past exposure to sun, skin phenotype, and risk of multiple sclerosis: case-control study
    I A F van der Mei
    Menzies Centre for Population Health Research, University of Tasmania, Hobart, TAS 7000, Australia
    BMJ 327:316. 2003
    ..To examine whether past high sun exposure is associated with a reduced risk of multiple sclerosis...
  20. ncbi Prevalence and associated factors with sunscreen use in Southern Brazil: A population-based study
    Rodrigo Pereira Duquia
    Programa de Pós Graduação em Epidemiologia, Universidade Federal de Pelotas, Brazil
    J Am Acad Dermatol 57:73-80. 2007
    ..Sunscreen use is important for the prevention of skin cancer, but population-based information about its prevalence and associated factors are scarce in Brazil...
  21. ncbi Ultraviolet sunlight exposure during adolescence and adulthood and breast cancer risk: a population-based case-control study among Ontario women
    Laura N Anderson
    Prevention and Cancer Control, Cancer Care Ontario, Toronto, Canada
    Am J Epidemiol 174:293-304. 2011
    ..The associations among ultraviolet radiation from sunlight, factors related to cutaneous vitamin D production, and breast cancer risk were evaluated in a population-based ..
  22. ncbi Anatomic site, sun exposure, and risk of cutaneous melanoma
    David C Whiteman
    Division of Population Studies and Human Genetics, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Queensland 4029 Australia e mail
    J Clin Oncol 24:3172-7. 2006
    b>Sunlight is the principal environmental risk factor for cutaneous melanoma. A current hypothesis postulates that the role of sunlight in causing melanoma differs according to anatomic site...
  23. pmc Vitamin D intake needed to maintain target serum 25-hydroxyvitamin D concentrations in participants with low sun exposure and dark skin pigmentation is substantially higher than current recommendations
    Laura M Hall
    Nutrition Department, University of California, Davis, CA, 95616, USA
    J Nutr 140:542-50. 2010
    ..To achieve 25(OH)D > or =75 nmol/L, we estimate that EA individuals with high sun exposure need 1300 iu/d vitamin D intake in the winter and AA individuals with low sun exposure need 2100-3100 iu/d year-round...
  24. ncbi Behavioral counseling to prevent skin cancer: a systematic review for the U.S. Preventive Services Task Force
    Jennifer S Lin
    Center for Health Research, Kaiser Permanente Northwest, 3800 North Interstate Avenue, Portland, OR 97227, USA
    Ann Intern Med 154:190-201. 2011
    ..More than 2 million cases of skin cancer are diagnosed annually in the United States, and melanoma incidence is increasing...
  25. ncbi Sunlight is associated with decreased multiple sclerosis risk: no interaction with human leukocyte antigen-DRB1*15
    M Bäärnhielm
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Eur J Neurol 19:955-62. 2012
    Both insufficient exposure to sunlight and vitamin D deficiency have been associated with an increased risk for multiple sclerosis (MS)...
  26. pmc Can breakfast tryptophan and vitamin B6 intake and morning exposure to sunlight promote morning-typology in young children aged 2 to 6 years?
    Miyo Nakade
    Department of Nutritional Management, Faculty of Health and Nutrition, Tokai Gakuen University, Nagoya, Japan
    J Physiol Anthropol 31:11. 2012
    ..of view, the integrated effects of the amount of tryptophan and vitamin B6 intake and the following exposure to sunlight on the circadian typology and sleep habits in young Japanese children aged 2 to 6 years, using the newly-..
  27. ncbi Photoenhanced toxicity of aqueous phase and chemically dispersed weathered Alaska North Slope crude oil to Pacific herring eggs and larvae
    Mace G Barron
    P E A K Research, 1134 Avon Lane, Longmont, Colorado 80501, USA
    Environ Toxicol Chem 22:650-60. 2003
    ..Brief exposure to sunlight (approximately 2.5 h/d for 2 d) significantly increased toxicity 1.5- to 48-fold over control lighting...
  28. ncbi The association between MC1R genotype and BRAF mutation status in cutaneous melanoma: findings from an Australian population
    Elke Hacker
    Genetics and Population Health Division, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Invest Dermatol 130:241-8. 2010
    ..BRAF-mutant melanomas have different origins from other cutaneous melanomas. These data support the divergent pathways hypothesis for melanoma, which may require a reappraisal of targeted cancer prevention activities...
  29. ncbi Biodiversity meets the atmosphere: a global view of forest canopies
    C M P Ozanne
    Centre for Research in Ecology and Environment, School of Life and Sport Sciences, University of Surrey Roehampton, West Hill, London SW15 3SN, UK
    Science 301:183-6. 2003
  30. ncbi Prevalence of vitamin D insufficiency in Brazilian adolescents
    Barbara Santarosa Emo Peters
    Nutrition Department, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil
    Ann Nutr Metab 54:15-21. 2009
    ..Cutaneous sun exposure and dietary vitamin D intake are important determinants of vitamin D status. The objective of the present study was to evaluate the vitamin D status of a group of healthy adolescent students living in Brazil...
  31. ncbi 25-Hydroxyvitamin D in Canadian adults: biological, environmental, and behavioral correlates
    L S Greene-Finestone
    Public Health Agency of Canada, Ottawa, Ontario, Canada
    Osteoporos Int 22:1389-99. 2011
    ..Results showed that serum 25-hydroxyvitamin D levels <75 nmol/L were common. Given Canada's high latitude, attention should be given to strategies for enhancing vitamin D status in the population...
  32. pmc Interaction between p53 codon 72 polymorphism and melanocortin 1 receptor variants on suntan response and cutaneous melanoma risk
    H Nan
    Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    Br J Dermatol 159:314-21. 2008
    ..The common p53 codon 72 polymorphism alters the protein's transcriptional activity, which may influence the UV radiation-induced tanning response...
  33. pmc Sunlight exposure, vitamin D, and risk of non-Hodgkin lymphoma in the Nurses' Health Study
    Kimberly A Bertrand
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 22:1731-41. 2011
    ..Evidence from prospective cohort studies, however, is limited and inconsistent. We evaluated the association between ambient ultraviolet radiation (UV) exposure and NHL in a nationwide cohort of women, the Nurses' Health Study (NHS)...
  34. pmc Ultraviolet A within sunlight induces mutations in the epidermal basal layer of engineered human skin
    Xiao Xuan Huang
    Discipline of Dermatology, Bosch Institute, Sydney Cancer Centre, The University of Sydney, New South Wales, Australia
    Am J Pathol 174:1534-43. 2009
    The ultraviolet B (UVB) waveband within sunlight is an important carcinogen; however, UVA is also likely to be involved...
  35. ncbi Vitamin D and sun protection: the impact of mixed public health messages in Australia
    Philippa H Youl
    Viertel Centre for Research in Cancer Control, Cancer Council Queensland, Brisbane, QLD, Australia
    Int J Cancer 124:1963-70. 2009
    Exposure of the skin to sunlight can cause skin cancer and is also necessary for cutaneous Vitamin D production. Media reports have highlighted the purported health benefits of Vitamin D...
  36. ncbi Vitamin D: A millenium perspective
    Michael F Holick
    Vitamin D Laboratory, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Cell Biochem 88:296-307. 2003
    ..Phytoplankton, zooplankton, and most plants and animals that are exposed to sunlight have the capacity to make vitamin D...
  37. ncbi Melanoma etiology: where are we?
    Margaret A Tucker
    Genetic Epidemiology Branch, DCEG, NCI, Executive Plaza South 7122, 6120 Executive Blvd, Rockville, MD 20892 7236, USA
    Oncogene 22:3042-52. 2003
    ..Recent surveys of sun behavior in the US reveal extensive sunburning and use of tanning beds in adolescents and adults. Sun protective behaviors are not as prevalent as in Australia, where population rates of melanoma are stabilizing...
  38. ncbi Vitamin D status in relation to obesity, bone mineral density, bone turnover markers and vitamin D receptor genotypes in healthy Saudi pre- and postmenopausal women
    M S M Ardawi
    Center of Excellence for Osteoporosis Research, King Abdulaziz University, P O Box No 20724, Jeddah, 21465, Saudi Arabia
    Osteoporos Int 22:463-75. 2011
    ..Vitamin D deficiency was highly prevalent among studied Saudi women with obesity, poor sunlight exposure, poor dietary vitamin D supplementation and age as the main risk factors.
  39. ncbi Who, what, where and when-influences on cutaneous vitamin D synthesis
    Ann R Webb
    University of Manchester, UK
    Prog Biophys Mol Biol 92:17-25. 2006
    ..At smaller SZAs assessment of solar exposure necessary for vitamin D synthesis can only be indicative and application of any such assessment necessarily requires awareness of both self- and the local environment...
  40. pmc Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate
    Julia A Newton-Bishop
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, UK
    Eur J Cancer 47:732-41. 2011
    ..A melanoma case-control study was conducted to elucidate the complex relationship between sun exposure and risk...
  41. ncbi Does solar exposure, as indicated by the non-melanoma skin cancers, protect from solid cancers: vitamin D as a possible explanation
    Pentti Tuohimaa
    Medical School, Department of Clinical Chemistry, University of Tampere, Tampere University Hospital, Tampere 33014, Finland
    Eur J Cancer 43:1701-12. 2007
    Skin cancers are known to be associated with sun exposure, whereas sunlight through the production of vitamin D may protect against some cancers...
  42. pmc Sun exposure and melanoma risk at different latitudes: a pooled analysis of 5700 cases and 7216 controls
    Yu Mei Chang
    Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, Leeds, UK
    Int J Epidemiol 38:814-30. 2009
    ..Melanoma risk is related to sun exposure; we have investigated risk variation by tumour site and latitude...
  43. ncbi Prevalence of vitamin D deficiency in Isfahani high school students in 2004
    Mohammad Moussavi
    Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
    Horm Res 64:144-8. 2005
    ..The prevalence of vitamin D deficiency was investigated in Isfahani male and female high school students in Iran in 2004...
  44. ncbi How sunlight causes melanoma
    Lilit Garibyan
    Department of Dermatology, Massachusetts General Hospital Boston, Harvard Medical School, Boston, MA 02114, USA
    Curr Oncol Rep 12:319-26. 2010
    ..It is generally accepted that ultraviolet light radiation (UVR) from sunlight is a major risk factor for melanoma skin cancer development...
  45. ncbi Sunlight exposure, antioxidants, and age-related macular degeneration
    Astrid E Fletcher
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London, England
    Arch Ophthalmol 126:1396-403. 2008
    To examine the association of sunlight exposure and antioxidant level with age-related macular degeneration (AMD).
  46. ncbi Effects of above average summer sun exposure on serum 25-hydroxyvitamin D and calcium absorption
    M Janet Barger-Lux
    Osteoporosis Research Center, Creighton University, 601 North 30th Street, Omaha, Nebraska 68131, USA
    J Clin Endocrinol Metab 87:4952-6. 2002
    ..Despite this input, at the late winter visit, 25(OH)D was less than 50 nmol/liter in 3 subjects and less than 75 nmol/liter in 15 subjects...
  47. ncbi Prevention of rickets and vitamin D deficiency in infants, children, and adolescents
    Carol L Wagner
    American College of Obstetrics and Gynecology
    Pediatrics 122:1142-52. 2008
    Rickets in infants attributable to inadequate vitamin D intake and decreased exposure to sunlight continues to be reported in the United States. There are also concerns for vitamin D deficiency in older children and adolescents...
  48. pmc Post-veraison sunlight exposure induces MYB-mediated transcriptional regulation of anthocyanin and flavonol synthesis in berry skins of Vitis vinifera
    José Tomás Matus
    Departamento de Fruticultura y Enología, Pontificia Universidad Catolica de Chile, Av Vicuña Mackenna 4560, Santiago, Chile
    J Exp Bot 60:853-67. 2009
    ..The impact of post-veraison sunlight exposure on anthocyanin and flavonol accumulation in grape berry skin and its relation to the expression of ..
  49. ncbi The melanocortin-1-receptor gene is the major freckle gene
    M Bastiaens
    Department of Dermatology and Department of Clinical Epidemiology, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands
    Hum Mol Genet 10:1701-8. 2001
    ..The results of the study also suggest that MC1R gene variants play a role, although less important, in the development of solar lentigines...
  50. ncbi Molecular mechanisms of skin aging: state of the art
    E Makrantonaki
    Laboratory for Biogerontology, Dermato Pharmacology and Dermato Endocrinology, Institute Clinical Pharmacology and Toxiology, Berlin, Berlin, Germany
    Ann N Y Acad Sci 1119:40-50. 2007
    ..Understanding the molecular mechanisms of aging may open new strategies in dealing with the various diseases accompanying aging, including cancer...
  51. ncbi Personal sun exposure and risk of non Hodgkin lymphoma: a pooled analysis from the Interlymph Consortium
    Anne Kricker
    School of Public Health, University of Sydney, Sydney, New South Wales, Australia
    Int J Cancer 122:144-54. 2008
    ..Increased recreational sun exposure may protect against NHL...
  52. ncbi Artificial and natural ultraviolet radiation exposure: beliefs and behaviour of 7200 French adults
    K Ezzedine
    Unité 557, Unité mixte de recherche INSERM INRA CNAM, Paris, France
    J Eur Acad Dermatol Venereol 22:186-94. 2008
    ..Despite the increasing use of indoor tanning facilities, little is known regarding the behaviour of adults with respect to artificial and natural ultraviolet (UV) radiation exposure and the relationship between the two forms of exposure...
  53. ncbi Determinants of BRAF mutations in primary melanomas
    Janet L Maldonado
    Department of Dermatology, University of California, San Francisco, San Francisco, CA 94115, USA
    J Natl Cancer Inst 95:1878-90. 2003
    ..The high mutation frequency in melanomas arising on intermittently sun-exposed skin suggests a complex causative role of such exposure that mandates further evaluation...
  54. ncbi Vitamin D: a D-Lightful health perspective
    Michael F Holick
    The Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, USA
    Nutr Rev 66:S182-94. 2008
    b>Sunlight provides most humans with their vitamin D requirement. Adequate vitamin D(3) by synthesis in the skin or from dietary and supplemental sources is essential for bone health throughout life...
  55. ncbi A serial analysis of gene expression in sun-damaged human skin
    Johann Urschitz
    The Pacific Biomedical Research Center, University of Hawaii, 1993 East West Road, Honolulu, HI 96822, U S A
    J Invest Dermatol 119:3-13. 2002
    ..These results suggest a major role for the epidermis in the pathomechanism of largely dermal changes in chronically sun-exposed skin...
  56. pmc Prevalence and risks factors of age-related macular degeneration in Oklahoma Indians: the Vision Keepers Study
    Amir L Butt
    Center for American Indian Health Research, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Ophthalmology 118:1380-5. 2011
    ..To determine the prevalence of age-related macular degeneration (AMD) and to identify its risk factors in an Oklahoma Indian population...
  57. ncbi Contributions of sunlight and diet to vitamin D status
    Helen M Macdonald
    Musculoskeletal Research, Health Sciences Building, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Calcif Tissue Int 92:163-76. 2013
    ..Regulatory mechanisms in the skin mean there is no danger of vitamin D toxicity through sunlight synthesis. Although oral vitamin D is potentially toxic with high-dose supplements, there is a wide safety margin...
  58. pmc On the interplay of telomeres, nevi and the risk of melanoma
    Clara Bodelon
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, United States of America
    PLoS ONE 7:e52466. 2012
    ..Larger studies across different populations are necessary to clarify these associations...
  59. ncbi Sunlight exposure and (sero)prevalence of epidermodysplasia verruciformis-associated human papillomavirus
    Fabian Termorshuizen
    Leiden University Medical Center, The Netherlands
    J Invest Dermatol 122:1456-62. 2004
    ..The favorable association between lifetime sun exposure and HPV prevalence, however, underscores the enigmatic role of HPV in skin carcinogenesis...
  60. ncbi The D-lightful vitamin D for child health
    Michael F Holick
    Department of Medicine, Boston University Medical Center, Boston, Massachusetts, USA
    JPEN J Parenter Enteral Nutr 36:9S-19S. 2012
    ..The Endocrine Society's Clinical Guidelines recommended that to prevent and treat vitamin D deficiency, children 0-1 year and 1-18 years need 400-1000 and 600-1000 IU/d, respectively...
  61. pmc Melanocytic nevi and sun exposure in a cohort of colorado children: anatomic distribution and site-specific sunburn
    Athena T Dodd
    Department of Preventive Medicine, University of Colorado at Denver and Health Sciences Center, 4200 East Ninth Avenue, Campus Box B119, Denver, CO 80262, USA
    Cancer Epidemiol Biomarkers Prev 16:2136-43. 2007
    ..03 for three or more sunburns), but not on the face, arms, or legs. In this high-risk population, there is evidence for two pathways to nevus accumulation: by chronic sun exposure and by intermittent exposure related to sunburns...
  62. pmc Effects of sunlight and diet on vitamin D status of pulmonary tuberculosis patients in Tbilisi, Georgia
    Nirali S Desai
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Nutrition 28:362-6. 2012
    ..Vitamin D deficiency is common in tuberculosis (TB) and this may modulate immune responses. This study investigated vitamin D status in patients with TB and examined the sources of vitamin D in Tbilisi, Georgia...
  63. ncbi Superparamagnetic plasmonic nanohybrids: shape-controlled synthesis, TEM-induced structure evolution, and efficient sunlight-driven inactivation of bacteria
    Yueming Zhai
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Changchun 130022, Jilin, People s Republic of China
    ACS Nano 5:8562-70. 2011
    ..Importantly, the double-layer nanotubes exhibited enhanced photocatalytic inactivation of bacteria at very low concentrations under natural sunlight.
  64. ncbi Association of 25-hydroxyvitamin D3)levels in adult New Zealanders with ethnicity, skin color and self-reported skin sensitivity to sun exposure
    Sofia Nessvi
    Faculty of Health Sciences, University of Linkoping, Linkoping, Sweden
    Photochem Photobiol 87:1173-8. 2011
    ..These results indicate that self-defined ethnicity was a major determinant of variations in serum 25(OH)D(3), while objective measures of skin color explained relatively little additional variation...
  65. ncbi Seasonal patterns in the sunlight sensitivity of bacterioplankton from Mediterranean surface coastal waters
    Clara Ruiz-González
    Institut de Ciències del Mar CSIC, Barcelona, Spain
    FEMS Microbiol Ecol 79:661-74. 2012
  66. ncbi UV radiation exposure related to age, sex, occupation, and sun behavior based on time-stamped personal dosimeter readings
    Elisabeth Thieden
    Department of Dermatology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    Arch Dermatol 140:197-203. 2004
    ..To assess individual time-related (time-stamped) UV radiation (UVR) dose pattern and sun exposure behavior...
  67. pmc Effect of natural sunlight on bacterial activity and differential sensitivity of natural bacterioplankton groups in northwestern Mediterranean coastal waters
    Laura Alonso-Sáez
    Departament de Biologia Marina i Oceanografia, Institut de Ciencies del Mar, 08003 Barcelona, Spain
    Appl Environ Microbiol 72:5806-13. 2006
    We studied the effects of natural sunlight on heterotrophic marine bacterioplankton in short-term experiments...
  68. ncbi New hypotheses on sunlight and the geographic variability of multiple sclerosis prevalence
    Bijal K Mehta
    Department of Neurology, Jacobs Neurological Institute, State University of New York Buffalo, 100 High Street, Buffalo, NY 14203, USA
    J Neurol Sci 292:5-10. 2010
    ..This paper will discuss how sunlight stimulus may effect neuronal and microglial antigenic presentation based on sunlight-dependent neuronal activity, ..
  69. pmc Semiconductor nanoparticle-based hydrogels prepared via self-initiated polymerization under sunlight, even visible light
    Da Zhang
    Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, P R China
    Sci Rep 3:1399. 2013
    ..The advantages of photo polymerization include the mild and easy process. However, the direct use of available sunlight for the preparation of materials is still a challenge due to its rather dilute intensity...
  70. ncbi Validity and reliability of adult recall of past sun exposure in a case-control study of multiple sclerosis
    I A F van der Mei
    Menzies Research Institute, University of Tasmania, Private Bag 23, Hobart, Tasmania 7001, Australia
    Cancer Epidemiol Biomarkers Prev 15:1538-44. 2006
    ..Measurement of past sun exposure through recall by adults has the potential for measurement error. We aimed to investigate aspects of validity and reliability of self-reported past sun exposure...
  71. ncbi A practical demonstration of water disinfection using TiO2 films and sunlight
    Silvia Gelover
    Instituto Mexicano de Tecnologia del Agua, iMTA, Paseo Cuauhnahuac 8532, Progreso, Jiutepec, Morelos 62550, Mexico
    Water Res 40:3274-80. 2006
    ..Spring water naturally polluted with coliform bacteria was exposed to sunlight in plastic bottles with and without TiO2 over simple solar collectors and the disinfection effectiveness was ..
  72. ncbi Evaluation of window-tinting films for sunlight phototherapy
    Hendrik J Vreman
    Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305 5208, USA
    J Trop Pediatr 59:496-501. 2013
    ..The data suggest that most of the relatively low-cost window-tinting films tested can effectively reduce sunlight UV and IR and offer a range of significant attenuations of therapeutic blue light.
  73. ncbi Latitude and incidence of ocular melanoma
    Guo Pei Yu
    Biostatistics and Epidemiology Service, The New York Eye and Ear Infirmary, USA
    Photochem Photobiol 82:1621-6. 2006
    ..latitude and the incidence of two different types of ocular melanoma, external ocular melanoma (exposed to sunlight) and internal melanoma (not exposed to sunlight), separately...
  74. ncbi Sunlight triggered photodynamic ultradeformable liposomes against Leishmania braziliensis are also leishmanicidal in the dark
    Jorge Montanari
    Programa de Nanomedicinas, Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes, Roque Saenz Pena 352, Bernal, B1876 BXD, Buenos Aires, Argentina
    J Control Release 147:368-76. 2010
    Being independent of artificial power sources, self administered sunlight triggered photodynamic therapy could be a suitable alternative treatment for cutaneous leishmaniasis, that avoids the need for injectables and the toxic side ..
  75. pmc Sunlight UV-induced skin cancer relies upon activation of the p38α signaling pathway
    Kangdong Liu
    The Hormel Institute, University of Minnesota, Austin, MN 55912, USA
    Cancer Res 73:2181-8. 2013
    ..e., sunlight) are not understood well enough to permit improvements for prevention, prognosis, and treatment...
  76. pmc Sunlight effects on the Osmotrophic uptake of DMSP-sulfur and leucine by polar phytoplankton
    Clara Ruiz-González
    Department of Marine Biology, Institut de Ciències del Mar CSIC, Barcelona, Spain
    PLoS ONE 7:e45545. 2012
    ..assimilation of both substrates occurred in the size fraction containing most phytoplankton (>5 µm), sunlight exposure generally increasing (35)S-DMSP-sulfur assimilation and decreasing (3)H-leucine assimilation...
  77. pmc Short- and long-term sunlight radiation and stroke incidence
    Shia T Kent
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, USA
    Ann Neurol 73:32-7. 2013
    Examine whether long- and short-term sunlight radiation is related to stroke incidence.
  78. ncbi Risk factors for vitamin D deficiency in women aged 20-50 years consulting in general practice: a cross-sectional study
    Marie France le Goaziou
    Department of General Practice, University Claude Bernard, Lyon 1, France
    Eur J Gen Pract 17:146-52. 2011
    ..Our objective was to estimate the influence of concealing clothes and other risk factors for vitamin D deficiency in women aged 20 to 50 years consulting general practitioners...
  79. ncbi Estimated ultraviolet exposure levels for a sufficient vitamin D status in North America
    V E Fioletov
    Environment Canada, Toronto, Ontario, Canada
    J Photochem Photobiol B 100:57-66. 2010
    ..The time required to obtain standard vitamin D dose is also calculated for six types of skin...
  80. pmc Reactivation of tuberculosis and vitamin D deficiency: the contribution of diet and exposure to sunlight
    A Sita-Lumsden
    Department of Respiratory Medicine, Guy s and St Thomas Foundation Trust, London, UK
    Thorax 62:1003-7. 2007
    ..undertaken to examine serum vitamin D concentrations before treatment in patients with active TB and their contacts from the same ethnic and social background and to investigate the relative contributions of diet and sunlight exposure.
  81. pmc Sunlight modulates the relative importance of heterotrophic bacteria and picophytoplankton in DMSP-sulphur uptake
    Clara Ruiz-González
    Institut de Ciències del Mar CSIC, Barcelona, Catalunya, Spain
    ISME J 6:650-9. 2012
    ..and little is known about their contribution to DMSP consumption and the potential modulating effects of sunlight. In an attempt to ascertain the relative quantitative roles of heterotrophic bacteria and picophytoplankton in ..
  82. ncbi Knowledge, motivation, and behavior patterns of the general public towards sun protection
    Jacqueline M Goulart
    Dermatology Service, Memorial Sloan Kettering Cancer Center, 136 Mountain View Blvd, Basking Ridge, NJ 07920, USA
    Photochem Photobiol Sci 9:432-8. 2010
    ..Future photoprotection messages should shift from purely promoting knowledge to inspiring improvements in behavior with targeted strategies...
  83. ncbi Sunlight-induced DNA damage in marine micro-organisms collected along a latitudinal gradient from 70 degrees N to 68 degrees S
    Jarah A Meador
    Science Park Research Division, The University of Texas M D Anderson Cancer Center, Smithville, TX, USA
    Photochem Photobiol 85:412-20. 2009
  84. ncbi Sunlight and the onset of skin cancer
    D E Brash
    Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06520 8040, USA
    Trends Genet 13:410-4. 1997
    The photons of sunlight precipitate a series of genetic events in skin leading to cancer. These events involve somatic mutations as well as inherited alleles...
  85. ncbi Sunlight, vitamin D and the prevention of cancer: a systematic review of epidemiological studies
    Han van der Rhee
    Department of Dermatology, HagaZiekenhuis, Den Haag, Zuid Holland, The Netherlands
    Eur J Cancer Prev 18:458-75. 2009
    The number of studies reporting beneficial effects of sunlight and vitamin D on several types of cancer with a high mortality rate is growing rapidly...
  86. ncbi MC1R gene polymorphism affects skin color and phenotypic features related to sun sensitivity in a population of French adult women
    Julie Latreille
    CE R I E S Research Centre on Human Skin founded by CHANEL, Neuilly sur Seine, France
    Photochem Photobiol 85:1451-8. 2009
    ..Our findings support the hypothesis that MC1R polymorphisms do not necessarily alter the skin color but should sensitize the skin to UV-induced DNA damage...
  87. ncbi The use of a 3895 bp mitochondrial DNA deletion as a marker for sunlight exposure in human skin
    Kim J Krishnan
    Dermatological Sciences, University of Newcastle, Newcastle upon Tyne, UK
    J Invest Dermatol 123:1020-4. 2004
    ..Additionally, we have linked the 3895 bp deletion with the UVR component of sunlight by inducing the deletion in vitro with repetitive sub-lethal doses of a UVA+UVB light source.
  88. ncbi Seasonal variation of serum vitamin D and the effect of vitamin D supplementation in Irish community-dwelling older people
    Roman Romero-Ortuno
    Trinity College Dublin TRIL Clinic, Hospital, St James s Hospital, Dublin 8, Co Dublin, Ireland
    Age Ageing 40:168-74. 2011
    ..However, in Irish older people, little is known about the magnitude of the supplementation effect and whether supplementation affects 25(OH)D seasonality...
  89. ncbi Vitamin D status of women in the Geelong Osteoporosis Study: association with diet and casual exposure to sunlight
    J A Pasco
    The University of Melbourne, Department of Clinical and Biomedical Sciences--Barwon Health, The Geelong Hospital, Vic
    Med J Aust 175:401-5. 2001
    ..Australia has no recommended dietary intake (RDI) for vitamin D, in the belief that adequate vitamin D can be obtained from solar irradiation alone. Our results suggest that an RDI may be needed...
  90. ncbi Solar and photocatalytic disinfection of protozoan, fungal and bacterial microbes in drinking water
    J Lonnen
    Department of Infection, Immunity and Inflammation, Maurice Shock Building, School of Medicine, University of Leicester, Leicester LE1 9HN, UK
    Water Res 39:877-83. 2005
    ..A reduction of only 1.7 log units was recorded for spores of Bacillus subtilis. Both SODIS and SPC-DIS were ineffective against the cyst stage of A. polyphaga...
  91. ncbi Genomic-driven insights into changes in aging skin
    Michael K Robinson
    Global Biotechnology, The Procter and Gamble Company, Miami Valley Innovation Center, Cincinnati, OH 45253, USA
    J Drugs Dermatol 8:s8-11. 2009
    ..However, skin is also exposed to external insults, such as sunlight. Aging due to chronic sun exposure (photoaging) is characterized clinically by wrinkling, dyspigmentation and ..
  92. ncbi Visual performance with sport-tinted contact lenses in natural sunlight
    Graham B Erickson
    Pacific University College of Optometry, OR 97116, USA
    Optom Vis Sci 86:509-16. 2009
    ..This study broadens previous research regarding performance-tinted CLs and their effects on measures of visual performance...
  93. ncbi Sufficient vitamin D from casual sun exposure?
    Frank R de Gruijl
    Department of Dermatology, Leiden University Medical Center LUCM, Leiden, The Netherlands
    Photochem Photobiol 87:598-601. 2011
    ..This result is an improvement over earlier estimates and shows that casual mid-day summer sun exposure should indeed suffice...
  94. ncbi Natural sunlight and residual fuel oils are an acutely lethal combination for fish embryos
    Kristin Hatlen
    Environmental Conservation Division, Northwest Fisheries Science Center, National Oceanic and Atmospheric Administration, 2725 Montlake Blvd E, Seattle, WA 98112, USA
    Aquat Toxicol 99:56-64. 2010
    ..potential toxicological differences between unrefined crude and residual fuel oils, and test the effects of sunlight as an additional stressor...
  95. ncbi Human papillomavirus type spectrum in normal skin of individuals with or without a history of frequent sun exposure
    Alice Che Ha Chen
    Diamantina Institute for Cancer, Immunology and Metabolic Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD 4102, Australia
    J Gen Virol 89:2891-7. 2008
    ..018). Interestingly, HPV-76 was only detected in the group without frequent sun-exposure (P=0.001). These results suggest that increased UV radiation exposure may be a factor leading to a difference in prevalence of cutaneous HPV types...
  96. ncbi The inactivation of microbes by sunlight: solar disinfection as a water treatment process
    Robert H Reed
    Division of Biomedical Sciences, Northumbria University, Newcastle upon Tyne NE1 8ST, United Kingdom
    Adv Appl Microbiol 54:333-65. 2004
  97. ncbi Sun exposure and number of nevi in 5- to 6-year-old European children
    Madeleine Dulon
    Department of Epidemiology and Medical Statistics, School of Public Health, University of Bielefeld, University Street 25, Germany
    J Clin Epidemiol 55:1075-81. 2002
    ..In conclusion, strategies to reduce the incidence of melanoma should begin with young children...
  98. ncbi Serum levels of vitamin D, sunlight exposure, and knee cartilage loss in older adults: the Tasmanian older adult cohort study
    Changhai Ding
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania
    Arthritis Rheum 60:1381-9. 2009
    To determine the associations between serum levels of vitamin D, sunlight exposure, and knee cartilage loss cross-sectionally and longitudinally in older adults.
  99. ncbi Prevalence and predictors of vitamin D inadequacy amongst Lebanese osteoporotic women
    Marie Hélène Gannagé-Yared
    Department of Endocrinology, Saint Joseph University, Hotel Dieu de France Hospital, Achrafieh, Beirut, Lebanon
    Br J Nutr 101:487-91. 2009
    ..001; P=002 and P=0.02 respectively). There is an urgent need to increase vitamin D supplement use in Middle-Eastern osteoporotic women, more particularly in those from the Muslim community...
  100. ncbi Vitamin D status and bone mineral density of veiled and unveiled Turkish women
    R Guzel
    Department of Physical Medicine and Rehabilitation, Cukurova University School of Medicine, Adana, Turkey
    J Womens Health Gend Based Med 10:765-70. 2001
    ..7 +/- 6.13 years, and 66.7% of the veiled women claimed that they were not ever exposed to direct sunlight, as they were leading an indoor life...
  101. ncbi Photodegradation of decabromodiphenyl ether in house dust by natural sunlight
    Heather M Stapleton
    Duke University, Nicholas School of the Environment and Earth Sciences, Durham, NC 27708, USA
    Environ Toxicol Chem 27:306-12. 2008
    ..In the present study, both a natural and a BDE 209-spiked dust material were exposed to sunlight for 200 cumulative h...

Research Grants72

    Keri Hammel; Fiscal Year: 2012
    ..Participants must agree to protect themselves from sunlight or artificial ultraviolet rays while in this study...
    Keri Hammel; Fiscal Year: 2013
    ..Participants must agree to protect themselves from sunlight or artificial ultraviolet rays while in this study...
  3. Biochemistry and Function of a Novel Bacterial Photosensory Two-Component System
    MELISSA MARKS; Fiscal Year: 2010
    ..Through this work we will gain a better understanding of the role the LovK/LovR two-component system and the ubiquitous environmental signal, sunlight, in the regulation of bacterial physiology and development.
  4. Evaluating the role of histone H3K79 methylation states in DNA damage repair in S
    Jeffrey S Thompson; Fiscal Year: 2010
    ..HEALTH RELEVANCE: Damage to genetic information by environmental agents, such as ultraviolet radiation from sunlight, poses a serious risk to the survival of living organisms...
  5. Effect Ultraviolet Radiation on Latent M. tuberculosis Infection in Guinea Pigs
    Amminikutty Jeevan; Fiscal Year: 2010
    ..The purpose of these studies is to determine whether an environmental toxin such as ultraviolet radiation from sunlight that is encountered on a daily basis contributes to the high incidence of tuberculosis by reactivating a latent ..
  6. A reconstructed skin model for development of treatments for albinism
    Seth J Orlow; Fiscal Year: 2010
    ..Individuals with OCA2 living in areas that experience intense sunlight, such as Arizona where OCA2 is more common among the Navajo, are at greatest risk...
  7. Coleus forskohlii extract: melanization and UV protection by a natural product
    JOHN DORAZIO; Fiscal Year: 2009
    ..Similar to fair- skinned humans who tend to burn rather than tan after sunlight exposure, our fair-skinned animals demonstrate heightened UV sensitivity and failure to tan adaptively...
  8. Melanoma Prevention: Using the Sun
    Marianne Berwick; Fiscal Year: 2013
    ..Examples of novel initiatives include exploration of interaction effects of sunlight and Vitamin D with the vitamin D receptor and its pathway, immunological factors and hormonal influences on both ..
  9. RNA quality control and environmental stress
    Sandra L Wolin; Fiscal Year: 2013
    ..RNAs can also be damaged by sunlight exposure and other environmental insults...
  10. The role of TNF-Alpha in cutaneous integrity
    Victoria P Werth; Fiscal Year: 2013
    ..UV is used therapeutically, and because our troops are serving or have returned from areas of the world where sunlight is particularly intense...
  11. Sunlight Exposure & Vitamin D Metabolic Gene Variations in Parkinson's Disease
    Beate R Ritz; Fiscal Year: 2010
    ..Vitamin D, which is produced in the body principally in response to sunlight exposure, influences numerous biological processes, and has been investigated for its potential role in diseases ..
  12. Biological and Environmental modifiers of Vitamin D3 and Prostate Cancer Risk
    RICK ANTONIUS KITTLES; Fiscal Year: 2013
    ..serum levels are strongly influenced by skin color, genetic ancestry, age, BMI, and environmental factors such as sunlight exposure and diet...
  13. Vitamin D: a link to racial disparities in birth outcomes
    Lisa M Bodnar; Fiscal Year: 2012
    ..Interventions to improve vitamin D status, such as a moderate increase in sunlight exposure or vitamin D supplementation, are inexpensive, safe, and acceptable to women...
  14. Vitamin D supplementation in pregnancy: impact on neonatal immune phenotype
    GEORGE T O'CONNOR; Fiscal Year: 2013
    ..One potential factor is vitamin D, acquired primarily via exposure to sunlight. A high prevalence of vitamin D insufficiency exists worldwide (11, 12), associated with autoimmunity, cancer (12,..
  15. Regulation and Function of C/EBP in UVB Responses
    Robert C Smart; Fiscal Year: 2010
    ..b>Sunlight, more specifically the UVB component of sunlight, causes DMA damage and is responsible for the majority of human ..
  16. Arsenic Induced Miotic Arrest Associated Apoptosis
    J Christopher States; Fiscal Year: 2009
    ..human cells to arsenite induced MAAA suggests that the mechanism of arsenite carcinogenesis is different than sunlight induced skin carcinogenesis in which p53 mutation is an early and common event...
  17. Functional Vitamin D Receptor Gene Variants and Racial/Ethnic Cancer Disparities
    Robin Taylor Wilson; Fiscal Year: 2010
    ..hypothesis that VDR and VDRE genotypes are independently associated with serum vitamin D, adjusting for age, sex, sunlight exposure, season, dietary intake, genetic ancestry, skin reflectance (melanin index)...
  18. DNA Repair Enzymes for the Prevention of Skin Cancer
    Amanda K McCullough; Fiscal Year: 2013 disease management, while disease prevention strategies focus on public education that advocates for limiting sunlight exposures, especially in the first two decades of life. However, with ~1...
  19. Identifying cellular and molecular interactions along the pathway to symbiosis
    Elizabeth A Vallen; Fiscal Year: 2012
    ..The algae, of the genus Symbiodinium, use energy from sunlight to make sugars from carbon dioxide and water, and give up to 90% of this sugar to the coral or anemone host...
  20. Multiplexed Quantification of DNA Damage Response
    Thomas J Begley; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Project Summary/Abstract Cigarette smoke, sunlight, and diagnostic computerized tomography (CT) are some of the many environmental exposures that can cause DNA damage...
  21. Role of ultraviolet radiation in Merkel cell carcinogenesis
    David M Owens; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Chronic exposure to sunlight is the underlying cause of 90% of skin cancers...
  22. Colony Stimulating Factor 1: Role in Photosensitive Cutaneous and Systemic Lupus
    Vicki Rubin Kelley; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Sunlight, ultraviolet (UV), exposure to the skin triggers cutaneous and systemic lupus (SLE) through an unknown mechanism...
  23. Epidemiology of Breast Cancer Subtypes in African American Women: a Consortium
    Julie R Palmer; Fiscal Year: 2013
    ..factors that may have been adaptive in Africa to endemic infectious disease (robust immune response) and intense sunlight (high skin pigmentation), but that in western society may result in hyper-inflammatory milieu and vitamin D ..
  24. Genetic Variants Influencing Response to Vitamin D in Colorectal Chemoprevention
    Elizabeth L Barry; Fiscal Year: 2012
    ..Supplementation is often required to increase levels of vitamin D because of insufficient dietary intake and sunlight exposure...
  25. Mechanisms of photocarcinogenesis in geriatric skin
    Jeffrey B Travers; Fiscal Year: 2013
    ..While it is clear that exposure to the ultraviolet components in sunlight (specifically UVB) can initiate and promote the development of NMSC, the reasons why some individuals develop ..
  26. Development of a Photoactivated Respiratory Support Device
    Richard Gilbert; Fiscal Year: 2009
    ..As an example, photosynthesis utilizes energy derived from sunlight to promote key metabolic processes in plants, while exchanging oxygen for carbon dioxide...
  27. Regulation of Caenorhabditis elegans DNA polymerase eta by regulated proteolysis
    Ashley B Williams; Fiscal Year: 2011
    ..XP-V patients are hypersensitive to sunlight and have an increased predisposition for skin cancer...
  28. Skin Cancer Chemoprevention by Silibinin: Mechanisms and Efficacy
    Rajesh Agarwal; Fiscal Year: 2013
    ..UVB (ultraviolet B) radiation from the sunlight is the main etiologic factor for skin cancer;primarily, it causes DNA damages in skin epidermal cells which, if ..
  29. Vitamin D and NKT Cell Regulation of Multiple Sclerosis
    Margherita T Cantorna; Fiscal Year: 2013
    ..There is data to suggest that increased levels of vitamin D (either through diet, supplements or sunlight exposure) are beneficial for multiple sclerosis (MS) patients...
  30. Determinants and Consequences of Low Vitamin D in Populations of African Descent
    Ramón Angel Durazo-Arvizu; Fiscal Year: 2013
    ..abnormality" in African Americans or does the 25(OH)D-iPTH system have sufficient plasticity to adapt to low sunlight exposure? Could the low 25(OH)D levels which result from the "gene- environment discordance" observed in dark ..
  31. Engineering Microbial Rhodopsins as Optical Voltage Sensors
    ADAM EZRA COHEN; Fiscal Year: 2013
    ..In the wild, this protein absorbs sunlight and pumps protons to generate a proton motive force...
  32. UV damage, repair, and mutagenesis
    Gerd P Pfeifer; Fiscal Year: 2013
    ..In Specific Aim II, we will try to demonstrate a molecular link between sunlight exposure and melanoma...
  33. Vitamin D Production by Sperti Lamp in Fat Malabsorption Patients
    JAMES GAMBLE SHEPHERD; Fiscal Year: 2010
    ..Studies suggest that increased exposure to sunlight and increased vitamin D intake reduces risk of many chronic diseases including autoimmune diseases, heart disease,..
  34. Striatal Dopamine Release in Response to Ultraviolet Light in Compulsive Tanners
    BRYON H ADINOFF; Fiscal Year: 2013
    ..Nevertheless, the voluntary exposure to sunlight continues unabated despite progressively increasing rates of ultraviolet radiation (UVR)-induced illness and ..
  35. Novel UV-induced DNA lesions as new signature mutations for melanoma
    Jue Judy Liu; Fiscal Year: 2013
    ..However, while repeated exposure to UV radiation from sunlight is known to increase the risks of developing all skin cancers by mutating the cellular DNA, currently known UVB-..
  36. Beta-catenin-specific regulation of the vitamin D pathway in colon cancer
    Stephen W Byers; Fiscal Year: 2012
    ..A wealth of epidemiological and animal model data supports the hypothesis that vitamin D and its analogues (and sunlight) are potent inhibitors of CRC and our own work shows that certain analogues of vitamin D can inhibit the growth ..
  37. Yale SPORE in Skin Cancer
    Ruth Halaban; Fiscal Year: 2013
    ..diagnosis and treatment of melanomas by performing translational studies in four subjects: a) (Genomic sunlight dosimeters for melanoma prevention (Project 1);b) The B7-H1/PD-1 pathway in melanoma immunity (Project 2);c) ..
  38. Mechanisms of UV-induced skin carcinogenesis
    Laura A Hansen; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Exposure to the ultraviolet (UV) component of sunlight is the major cause of nonmelanoma skin cancer, the most common form of cancer in the United States...
  39. Inhibition of skin cancer by caffeine: Effects on late stages of carcinogenesis
    YAOPING LU; Fiscal Year: 2012
    b>Sunlight-induced skin cancer is the most prevalent cancer in the United States. In earlier studies we treated SKH-1 mice with UVB twice a week for 20 weeks...
  40. Vitamin D Fluctuations and the Mucosal Immune Response
    Margherita T Cantorna; Fiscal Year: 2013
    ..Vitamin D status has been shown to change with season as a result of decreased sunlight exposure that produces vitamin D in the skin. In addition, the diet is a relatively poor source of vitamin D...
  41. Serum Vitamin D and Cardiovascular Disease Risk in the Biethnic ARIC Cohort
    Pamela L Lutsey; Fiscal Year: 2013
    ..of the general population has suboptimal vitamin D levels, which are amenable to correction through increased sunlight exposure and/or dietary supplementation, elucidating the role of vitamin D in CVD risk is of vital public health ..
  42. Role of DNA polymerase eta in errorfree bypass of DNA lesions &cancer prevention
    Aneel K Aggarwal; Fiscal Year: 2013
    ..contribution toward delineating the mechanisms by which Pol? guards cells against the genotoxic effects of sunlight-induced chromosomal damage as well as damage induced from endogenous oxidation reactions and by chemotherapy...
  43. Transport processes in photoreceptors
    Yiannis Koutalos; Fiscal Year: 2012
    ..the leading cause of blindness in the US, metabolic diseases like diabetes, and damage to the retina inflicted by sunlight or by ophthalmic instruments...
  44. Codrugs of Lipoic Acid and Tocopherol/Tocopheramine for Use as Photoprotective Ag
    Martha A Hass; Fiscal Year: 2011
    ..provided by applicant): Acute and chronic exposure of the skin to ultraviolet radiation (UVR) in natural sunlight induces damaging effects including sunburn, photo aging, photosensitivity and skin cancer...
  45. Does UV-induced Unconventional Mast Cell Migration Activate Immune Suppression?
    Stephen E Ullrich; Fiscal Year: 2012
    ..migration from the skin to the lymph nodes is critically important for the induction of immune suppression and sunlight-induced skin carcinogenesis. The goal of the experiments outlined in this proposal is to test this hypothesis...
  46. Effect of UVA Irradiation on Melanocyte Stem Cells and Relationship to Developmen
    JAMES DOUGLAS HOERTER; Fiscal Year: 2012
    ..b>Sunlight ultraviolet radiation (UV) is the prominent environmental carcinogen known to be involved in melanoma...
  47. Design Principals of Photobiological Metabolism
    Daniel C Ducat; Fiscal Year: 2012
    ..will result in the construction of strains of cyanobacteria capable of producing hydrogen gas directly from sunlight. The results of these experiments will have relevance for the understanding of photosynthetic metabolism...
  48. DBP and the bioavailability and function of vitamin D
    Martin Hewison; Fiscal Year: 2013
    ..vitamin D-insufficiency, and how optimal vitamin D status can be safely achieved through conventional exposure to sunlight and dietary intake...
  49. Inhibitory effects of caffeine, exercise and lipectomy on UVB-induced skin cancer
    YAOPING LU; Fiscal Year: 2012
    b>Sunlight-induced skin cancer is the most prevalent cancer in the United States, and UVB is primarily responsible for these cancers...
  50. Efficacy of 25-hydroxyvitamin D3 in colon cancer chemoprevention
    Rajendra G Mehta; Fiscal Year: 2010
    ..evidence demonstrates an inverse relationship between vitamin D, both dietary intake and exposure to sunlight, and risk of developing colon cancer...
  51. DNA Excision Repair and DNA Damage Checkpoints
    Aziz Sancar; Fiscal Year: 2013
    ..of this study will enable us to make specific recommendations to lower the incidence of skin cancer induced by sunlight and other UV sources. Aim 2. Biochemical Analysis of the UV-Induced DNA Damage Checkpoint...
  52. Vitamin D3 Inhibition of Hedgehog Signaling and Cancer Chemoprevention
    ERVIN HAROLD EPSTEIN; Fiscal Year: 2013
    ..Such variation has been known for nearly 70 years, and a prime role for sunlight-produced vitamin D stores has been postulated to be the mechanistic connection for three decades...
  53. Population-Based Approach to Skin Cancer Epidemiology
    Abrar A Qureshi; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Sunlight is an environmental risk factor for skin cancer. A great deal of work has been done to characterize and quantify sun exposure...
  54. "Studies to examine Centrin's role in DNA repair"
    Kiran Madura; Fiscal Year: 2010
    ..Nucleotide excision repair plays a central role in the removal of sunlight-light induced DNA damage, and an important protein in this cellular defense mechanism is Rad4...
  55. The Role of E2F1 in UV-induced DNA Damage Response
    THOMAS BERTON; Fiscal Year: 2009
    The primary cause of skin cancer is chronic exposure to ultraviolet (UV) rays from sunlight. A crucial event in the prevention of UV-induced skin cancer is the repair of DNA damage and / or the removal of the damaged cell through ..
  56. Mechanisms of UVA-induced skin cancer
    Yu Ying He; Fiscal Year: 2013
    ..The major environmental risk factor for non-melanoma skin cancer is ultraviolet (UV) radiation in sunlight including UVB and UVA...
  57. Tumorigenic moisturizing creams: mechanisms and active constituents
    Allan H Conney; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sunlight-induced nonmelanoma skin cancer is the most revalent cancer in the United States with more than one million cases per year (almost as many cases as for all of the other cancers combined), and ..
  58. GHSU Minority-Based Community Clinical Oncology Program
    Sharad Ghamande; Fiscal Year: 2013 along with the expert advice of cancer patient advisors, the new facility brings in nature and sunlight, t welcomes family and friends, and it puts patients in charge in as many ways possible...
  59. A Hard and Clear, Estrogen-Free Replacement for Bisphenol-A Based Polycarbonates
    DANIEL JAMES KLEIN; Fiscal Year: 2013
    ..g., PC plastics), especially when exposed to sunlight or other UV wavelengths...
  60. Neural Basis for SAD: Development of a Diurnal Rodent Model
    Lily Yan; Fiscal Year: 2013
    ..that affects millions of Americans, who suffer recurring depressive symptoms in the winter when there is less sunlight. The leading theory for explaining SAD is the phase-shifting hypothesis, which suggests that the depressive ..
  61. Structural models to untangle triggers of ocular/nonocular herpesvirus recurrence
    Stephen R Cole; Fiscal Year: 2012
    Abstract The overall goal of this proposal is to quantify independent effects of sunlight exposure and psychological stress on recurrence of clinical ocular and nonocular herpes simplex virus (HSV) infections...
  62. Enviromental Exposures, Host Factors and Human Disease
    Frank D Gilliland; Fiscal Year: 2013
    ..Pollution, Neurodevelopment and Neurological Diseases;Global Environmental Health and Climate Change;and Sunlight in Health and Disease...
  63. Solar Water Disinfection: Randomized Intervention Trial
    JOHN COLFORD; Fiscal Year: 2006
    ..context solar disinfection of drinking water is especially appealing using a combination of irradiation by direct sunlight and solar heating to kill the water-borne pathogens in contaminated drinking water...
    ..The fact that UV-B radiation present in sunlight is known to be responsible for the induction of most human skin cancers, together with the investigators' ..
    Qingyi Wei; Fiscal Year: 2000
    Although sunlight exposure has been implicated in risk of cutaneous malignant melanoma (CMM), the exact role of ultraviolet light (UV in the etiology of CMM remains unclear. Host susceptibility to UV damage may also play an important role...
  66. Relationships between Skin Pigmentation, Vitamin D and Blood Pressure
    FLOJAUNE GRIFFIN; Fiscal Year: 2009 blood pressure is that many African Americans, who largely have darker skin than whites, obtain insufficient sunlight due to geographical location and limited outdoor exposure which, leads to inadequate vitamin D for healthy ..
  67. Vitamin D in the Cornea and Anterior Segment of the Eye
    Mitchell A Watsky; Fiscal Year: 2010
    ..The primary route for Vit D synthesis in the human body is through UV-B irradiation of the skin via sunlight. We propose to study Vit D synthesis and metabolism in the cornea, one of the few other tissues that receives ..
  68. Vitamin D, alcohol, and risk of lymphomas in a prospective cohort of women
    ELLEN TING YEE CHANG; Fiscal Year: 2010
    ..studies of diet and NHL risk, and none of HL or MM risk;there has been no prospective investigation of sunlight and risk of these cancers...
  69. Role of senescent fibroblasts in UVB-induced carcinogenesis
    Dan F Spandau; Fiscal Year: 2010
    ..risk factor for developing skin cancer is exposure to ultraviolet wavelengths of light (UVB) found in sunlight. Although skin cancer can occur at any age, there is a strong correlation between the development of skin cancer ..
    Patrick Hayden; Fiscal Year: 2001
    ..Despite greater awareness by the public of the harmful effects of exposure to sunlight and increased use of sunscreens, skin cancer rates have continued to rise...
    J States; Fiscal Year: 1992
    ..The high frequency of epidermal neoplasms is due to an inability to repair DNA damage caused by exposure to sunlight. The elevated prevalence of internal neoplasms is probably linked to the heightened sensitivity of XP cells to ..
  72. Vitamins help regulate the expression of trafficking receptors on T cells.
    Hekla Sigmundsdottir; Fiscal Year: 2007
    ..vitamin A induces gut homing properties on human T cells, as reported in the mouse; and that the skin-specific (sunlight-induced) vitamin D3 induces T cell expression of CC chemokine receptor 10 and chemotaxis to the epidermal ..