altitude

Summary

Top Publications

  1. ncbi The use of 'altitude' in ecological research
    Christian Korner
    Institute of Botany, University of Basel, Schönbeinstrasse 6, Basel, CH 4056, Switzerland
    Trends Ecol Evol 22:569-74. 2007
  2. pmc Sequencing of 50 human exomes reveals adaptation to high altitude
    Xin Yi
    BGI Shenzhen, Shenzhen 518083, China
    Science 329:75-8. 2010
  3. ncbi Genetic evidence for high-altitude adaptation in Tibet
    Tatum S Simonson
    Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Science 329:72-5. 2010
  4. ncbi The yak genome and adaptation to life at high altitude
    Qiang Qiu
    State Key Laboratory of Grassland Agro Ecosystem, College of Life Science, Lanzhou University, Lanzhou, China
    Nat Genet 44:946-9. 2012
  5. ncbi Enhancing team-sport athlete performance: is altitude training relevant?
    Francois Billaut
    School of Sport and Exercise Science, Institute of Sport, Exercise and Active Living ISEAL, Victoria University, Melbourne, Vic, Australia
    Sports Med 42:751-67. 2012
  6. ncbi A genome-wide search for signals of high-altitude adaptation in Tibetans
    Shuhua Xu
    Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Mol Biol Evol 28:1003-11. 2011
  7. ncbi Influence of cerebral and muscle oxygenation on repeated-sprint ability
    Kurt J Smith
    Integrative Physiology Unit, University of Lethbridge, Lethbridge, AB, Canada
    Eur J Appl Physiol 109:989-99. 2010
  8. ncbi A significant upward shift in plant species optimum elevation during the 20th century
    J Lenoir
    AgroParisTech, UMR 1092, Laboratoire d Etude des Ressources Forêt Bois LERFoB, 14 rue Girardet, F 54000 Nancy, France
    Science 320:1768-71. 2008
  9. pmc Effect of short-term acclimatization to high altitude on sleep and nocturnal breathing
    Yvonne Nussbaumer-Ochsner
    Pulmonary Division and Sleep Disorders Center, University Hospital of Zurich, and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Sleep 35:419-23. 2012
  10. ncbi The effects of classic altitude training on hemoglobin mass in swimmers
    N B Wachsmuth
    Department of Sports Medicine Sports Physiology, University of Bayreuth, 95440 Bayreuth, Germany
    Eur J Appl Physiol 113:1199-211. 2013

Detail Information

Publications401 found, 100 shown here

  1. ncbi The use of 'altitude' in ecological research
    Christian Korner
    Institute of Botany, University of Basel, Schönbeinstrasse 6, Basel, CH 4056, Switzerland
    Trends Ecol Evol 22:569-74. 2007
    ..However, there are two categories of environmental changes with altitude: those physically tied to meters above sea level, such as atmospheric pressure, temperature and clear-sky ..
  2. pmc Sequencing of 50 human exomes reveals adaptation to high altitude
    Xin Yi
    BGI Shenzhen, Shenzhen 518083, China
    Science 329:75-8. 2010
    Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18x per individual...
  3. ncbi Genetic evidence for high-altitude adaptation in Tibet
    Tatum S Simonson
    Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Science 329:72-5. 2010
    ..that reveal positive selection in several regions that contain genes whose products are likely involved in high-altitude adaptation...
  4. ncbi The yak genome and adaptation to life at high altitude
    Qiang Qiu
    State Key Laboratory of Grassland Agro Ecosystem, College of Life Science, Lanzhou University, Lanzhou, China
    Nat Genet 44:946-9. 2012
    Domestic yaks (Bos grunniens) provide meat and other necessities for Tibetans living at high altitude on the Qinghai-Tibetan Plateau and in adjacent regions...
  5. ncbi Enhancing team-sport athlete performance: is altitude training relevant?
    Francois Billaut
    School of Sport and Exercise Science, Institute of Sport, Exercise and Active Living ISEAL, Victoria University, Melbourne, Vic, Australia
    Sports Med 42:751-67. 2012
    ..Matches may also be played at moderate altitude where the lower oxygen partial pressure exerts a detrimental effect on performance...
  6. ncbi A genome-wide search for signals of high-altitude adaptation in Tibetans
    Shuhua Xu
    Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Mol Biol Evol 28:1003-11. 2011
    ..in the world, may offer a unique opportunity to understand the biological adaptations of human beings to high-altitude environments...
  7. ncbi Influence of cerebral and muscle oxygenation on repeated-sprint ability
    Kurt J Smith
    Integrative Physiology Unit, University of Lethbridge, Lethbridge, AB, Canada
    Eur J Appl Physiol 109:989-99. 2010
    ..By using a hypoxia paradigm, the study suggests that cerebral oxygenation contributes to the impairment of repeated-sprint ability...
  8. ncbi A significant upward shift in plant species optimum elevation during the 20th century
    J Lenoir
    AgroParisTech, UMR 1092, Laboratoire d Etude des Ressources Forêt Bois LERFoB, 14 rue Girardet, F 54000 Nancy, France
    Science 320:1768-71. 2008
    ..Our study shows that climate change affects the spatial core of the distributional range of plant species, in addition to their distributional margins, as previously reported...
  9. pmc Effect of short-term acclimatization to high altitude on sleep and nocturnal breathing
    Yvonne Nussbaumer-Ochsner
    Pulmonary Division and Sleep Disorders Center, University Hospital of Zurich, and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Sleep 35:419-23. 2012
    Objective physiologic data on sleep and nocturnal breathing at initial exposure and during acclimatization to high altitude are scant...
  10. ncbi The effects of classic altitude training on hemoglobin mass in swimmers
    N B Wachsmuth
    Department of Sports Medicine Sports Physiology, University of Bayreuth, 95440 Bayreuth, Germany
    Eur J Appl Physiol 113:1199-211. 2013
    Aim of the study was to determine the influence of classic altitude training on hemoglobin mass (Hb-mass) in elite swimmers under the following aspects: (1) normal oscillation of Hb-mass at sea level; (2) time course of adaptation and de-..
  11. ncbi Physiological and performance responses to a preseason altitude-training camp in elite team-sport athletes
    Blake D McLean
    Collingwood Football Club, Melbourne, Australia
    Int J Sports Physiol Perform 8:391-9. 2013
    Little research has been done on the physiological and performance effects of altitude training on team-sport athletes...
  12. ncbi Global warming, elevational range shifts, and lowland biotic attrition in the wet tropics
    Robert K Colwell
    Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA
    Science 322:258-61. 2008
    ....
  13. ncbi Sea-level exercise performance following adaptation to hypoxia: a meta-analysis
    Darrell L Bonetti
    Institute of Sport and Recreation Research, School of Sport and Recreation, AUT University, Auckland, New Zealand
    Sports Med 39:107-27. 2009
    Adaptation to living or training in hypoxic environments (altitude training) continues to gain interest from sport scientists and endurance athletes...
  14. ncbi Preparation for football competition at moderate to high altitude
    C J Gore
    Department of Physiology, Australian Institute of Sport, Canberra, Australia
    Scand J Med Sci Sports 18:85-95. 2008
    ..100 years of home-and-away South American World Cup matches illustrate that football competition at moderate/high altitude (>2000 m) favors the home team, although this is more than compensated by the likelihood of sea-level teams ..
  15. ncbi Enhanced AFLP genome scans detect local adaptation in high-altitude populations of a small rodent (Microtus arvalis)
    Martin C Fischer
    Computational and Molecular Population Genetics, Institute of Ecology and Evolution, University of Bern, Baltzerstrasse 6, Bern, Switzerland
    Mol Ecol 20:1450-62. 2011
    Adaptation to adverse environmental conditions such as high altitude requires physiological and/or morphological changes...
  16. pmc Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans
    Fuyun Ji
    lnstitute of Human Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
    Proc Natl Acad Sci U S A 109:7391-6. 2012
    ..7). In high-altitude Tibetan and Indian populations, the 3394C variant occurs on five different macrohaplogroup M haplogroup ..
  17. ncbi Time course of the hemoglobin mass response to natural altitude training in elite endurance cyclists
    L Garvican
    Department of Physiology, Australian Institute of Sport, Canberra, Australia
    Scand J Med Sci Sports 22:95-103. 2012
    To determine the time course of hemoglobin mass (Hb(mass)) to natural altitude training, Hb(mass), erythropoietin [EPO], reticulocytes, ferritin and soluble transferrin receptor (sTfR) were measured in 13 elite cyclists during, and 10 ..
  18. pmc Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106 7125, USA
    Proc Natl Acad Sci U S A 107:11459-64. 2010
    By impairing both function and survival, the severe reduction in oxygen availability associated with high-altitude environments is likely to act as an agent of natural selection...
  19. pmc Two routes to functional adaptation: Tibetan and Andean high-altitude natives
    Cynthia M Beall
    Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 104:8655-60. 2007
    ..for natural selection for traits that offset the unavoidable environmental stress of severe lifelong high-altitude hypoxia...
  20. ncbi Spatial clustering of malaria and associated risk factors during an epidemic in a highland area of western Kenya
    Simon Brooker
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
    Trop Med Int Health 9:757-66. 2004
    ..Household geographical location and altitude were determined using a hand-held geographical positioning system and landcover types were determined using high ..
  21. ncbi Long-term outcome after ICD and CRT implantation and influence of remote device follow-up: the ALTITUDE survival study
    Leslie A Saxon
    University of Southern California, Keck School of Medicine, Cardiovascular and Thoracic Institute, Los Angeles, CA 90033, USA
    Circulation 122:2359-67. 2010
    ..No clinical trial has evaluated mortality after device implantation or after shock therapy in large numbers of patients with implanted devices that regularly transmit device data over a network...
  22. ncbi Neocytolysis on descent from altitude: a newly recognized mechanism for the control of red cell mass
    L Rice
    Section of Hematology, Department of Medicine, Baylor College of Medicine, 6565 Fannin, MS 902 Main, Houston, TX 77030, USA
    Ann Intern Med 134:652-6. 2001
    ..Studies of space-flight anemia have uncovered a physiologic process, neocytolysis, by which young red blood cells are selectively hemolyzed, allowing rapid adaptation when red cell mass is excessive for a new environment...
  23. pmc High altitude adaptation in Daghestani populations from the Caucasus
    Luca Pagani
    The Wellcome Trust Sanger Institute, Hinxton, UK
    Hum Genet 131:423-33. 2012
    We have surveyed 15 high-altitude adaptation candidate genes for signals of positive selection in North Caucasian highlanders using targeted re-sequencing...
  24. pmc Genetic signatures reveal high-altitude adaptation in a set of ethiopian populations
    Emilia Huerta-Sanchez
    Department of Integrative Biology, University of California, Berkeley, CA, USA
    Mol Biol Evol 30:1877-88. 2013
    The Tibetan and Andean Plateaus and Ethiopian highlands are the largest regions to have long-term high-altitude residents. Such populations are exposed to lower barometric pressures and hence atmospheric partial pressures of oxygen...
  25. pmc Malaria in the African highlands: past, present and future
    S W Lindsay
    Department of Biological Sciences, University of Durham, England
    Bull World Health Organ 76:33-45. 1998
    ..We further recommend that a regional modelling approach should be adopted to assess the extent and severity of this problem and help improve disease surveillance and the quality of health care delivered in this unstable ecosystem...
  26. ncbi Time course of haemoglobin mass during 21 days live high:train low simulated altitude
    Sally A Clark
    Department of Physiology, Australian Institute of Sport, PO Box 176, Belconnen, ACT, 2616, Australia
    Eur J Appl Physiol 106:399-406. 2009
    ..Twelve well-trained male cyclists participated in a 3-week LHTL protocol comprising 3,000 m simulated altitude for ~14 h/day...
  27. ncbi Does 'altitude training' increase exercise performance in elite athletes?
    Carsten Lundby
    Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Br J Sports Med 46:792-5. 2012
    The general practice of altitude training is widely accepted as a means to enhance sport performance despite a lack of rigorous scientific studies...
  28. ncbi Sleep architecture changes during a trek from 1400 to 5000 m in the Nepal Himalaya
    Pamela L Johnson
    David Read Laboratory, Department of Medicine, University of Sydney, Sydney, NSW 2006, Australia
    J Sleep Res 19:148-56. 2010
    The aim of this study was to examine sleep architecture at high altitude and its relationship to periodic breathing during incremental increases in altitude...
  29. ncbi Red cell volume expansion at altitude: a meta-analysis and Monte Carlo simulation
    Peter Rasmussen
    Zurich Center of Integrative Human Physiology, Institute of Physiology, Zurich, Switzerland
    Med Sci Sports Exerc 45:1767-72. 2013
    b>Altitude acclimatization is associated with a rapid increase in hematocrit. The time course and the contribution of the red cell volume expansion are not clear...
  30. ncbi "Live high-train low" using normobaric hypoxia: a double-blinded, placebo-controlled study
    Christoph Siebenmann
    Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland
    J Appl Physiol (1985) 112:106-17. 2012
    The combination of living at altitude and training near sea level [live high-train low (LHTL)] may improve performance of endurance athletes...
  31. pmc Genetic adaptation to high altitude in the Ethiopian highlands
    Laura B Scheinfeldt
    Department of Genetics, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Genome Biol 13:R1. 2012
    Genomic analysis of high-altitude populations residing in the Andes and Tibet has revealed several candidate loci for involvement in high-altitude adaptation, a subset of which have also been shown to be associated with hemoglobin levels, ..
  32. ncbi Changes in climatic water balance drive downhill shifts in plant species' optimum elevations
    Shawn M Crimmins
    Department of Forest Management, College of Forestry and Conservation, University of Montana, Missoula, MT 59812, USA
    Science 331:324-7. 2011
    ..Similar downhill shifts can be expected to occur where future climate change scenarios project increases in water availability that outpace evaporative demand...
  33. pmc The genetic architecture of adaptations to high altitude in Ethiopia
    Gorka Alkorta-Aranburu
    Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
    PLoS Genet 8:e1003110. 2012
    ..For each ethnic group, we sampled low and high altitude residents, thus allowing genetic and phenotypic comparisons across altitudes and across ethnic groups...
  34. pmc Living the high life: high-altitude adaptation
    Laura B Scheinfeldt
    Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genome Biol 11:133. 2010
    Genome-wide scans demonstrate that genetic variants associated with high-altitude adaptation in Tibetans and Andeans arose independently as a result of convergent adaptation.
  35. ncbi Optimal time of arrival for performance at moderate altitude (1700 m)
    A R Weston
    Department of Physiology, University of Natal Medical School, Congella, Natal 4013, South Africa
    Med Sci Sports Exerc 33:298-302. 2001
    The time course of physiological exercise responses after acute ascent to moderate altitude was investigated.
  36. ncbi Effectiveness of intermittent training in hypoxia combined with live high/train low
    Eileen Y Robertson
    Department of Physiology, Australian Institute of Sport, Canberra, Australia
    Eur J Appl Physiol 110:379-87. 2010
    Elite athletes often undertake altitude training to improve sea-level athletic performance, yet the optimal methodology has not been established...
  37. ncbi Effect of hypoxic "dose" on physiological responses and sea-level performance
    Randall L Wilber
    Athlete Performance Laboratory, United States Olympic Committee, Colorado Springs, CO 80909, USA
    Med Sci Sports Exerc 39:1590-9. 2007
    Live high-train low (LH+TL) altitude training was developed in the early 1990s in response to potential training limitations imposed on endurance athletes by traditional live high-train high (LH+TH) altitude training...
  38. ncbi Update on high-altitude pulmonary edema: pathogenesis, prevention, and treatment
    Joshua O Stream
    Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    Wilderness Environ Med 19:293-303. 2008
    High-altitude pulmonary edema (HAPE) is a life-threatening noncardiogenic form of pulmonary edema (PE) that afflicts susceptible persons after rapid ascent to high altitude above 2500 m...
  39. ncbi Genetic determinants of Tibetan high-altitude adaptation
    Tatum S Simonson
    Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Hum Genet 131:527-33. 2012
    ..e., polycythemia). Recent studies have highlighted several genes subject to natural selection in native high-altitude Tibetans...
  40. ncbi Reproducibility of performance changes to simulated live high/train low altitude
    Eileen Y Robertson
    Department of Physiology, Australian Institute of Sport, Canberra, Australia
    Med Sci Sports Exerc 42:394-401. 2010
    Elite athletes often undertake multiple altitude exposures within and between training years in an attempt to improve sea level performance.
  41. ncbi Combining hypoxic methods for peak performance
    Gregoire P Millet
    ISSUL, Institute of Sport Science, University of Lausanne, Lausanne, Switzerland
    Sports Med 40:1-25. 2010
    New methods and devices for pursuing performance enhancement through altitude training were developed in Scandinavia and the USA in the early 1990s...
  42. ncbi Physiological adaptation of the cardiovascular system to high altitude
    Robert Naeije
    Erasme University Hospital, Brussels, Belgium
    Prog Cardiovasc Dis 52:456-66. 2010
    b>Altitude exposure is associated with major changes in cardiovascular function...
  43. ncbi The contribution of haemoglobin mass to increases in cycling performance induced by simulated LHTL
    Laura A Garvican
    Sports Science Sports Medicine, Australian Institute of Sport, PO Box 176, Belconnen, Canberra, ACT, 2616, Australia
    Eur J Appl Physiol 111:1089-101. 2011
    ..However, increases in Hb(mass) appear to influence the aerobic contribution to high-intensity exercise which may be important for subsequent high-intensity efforts...
  44. ncbi Plasma adipokine and hormone changes in mountaineers on ascent to 5300 meters
    Jessica D Smith
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Quebec, QC, Canada
    Wilderness Environ Med 22:107-14. 2011
    ..In particular, acylation-stimulating protein (ASP), which influences fat storage in adipose tissue, has not been measured at high altitude.
  45. ncbi Altitude and endurance training
    Heikki K Rusko
    KIHU Research Institute for Olympic Sports, Jyvaskyla, Finland
    J Sports Sci 22:928-44; discussion 945. 2004
    The benefits of living and training at altitude (HiHi) for an improved altitude performance of athletes are clear, but controlled studies for an improved sea-level performance are controversial...
  46. ncbi Acclimatization of skeletal muscle mitochondria to high-altitude hypoxia during an ascent of Everest
    Denny Z Levett
    Centre for Altitude, Space, and Extreme Environment Medicine, University College London UCL Institute of Child Health, University College London, London, UK
    FASEB J 26:1431-41. 2012
    Ascent to high altitude is associated with a fall in the partial pressure of inspired oxygen (hypobaric hypoxia)...
  47. ncbi Peopling the Tibetan plateau: insights from archaeology
    Mark Aldenderfer
    School of Social Sciences, Humanities, and Arts, University of California, Merced, CA 95343, USA
    High Alt Med Biol 12:141-7. 2011
    ....
  48. ncbi High altitude exposure impairs sleep patterns, mood, and cognitive functions
    Valdir de Aquino Lemos
    Departamento de Psicobiologia Campus São Paulo, Universidade Federal de Sao Paulo, Sao Paulo, Brasil
    Psychophysiology 49:1298-306. 2012
    ..Ten males, aged 23-30 years, were placed in a normobaric chamber simulating an altitude of 4,500 m...
  49. ncbi Blood volume and hemoglobin mass in endurance athletes from moderate altitude
    Walter Schmidt
    Dept of Sports Medicine and Sports Physiology, University of Bayreuth, 95440 Bayreuth, Germany
    Med Sci Sports Exerc 34:1934-40. 2002
    To determine whether total hemoglobin (tHb) mass and total blood volume (BV) are influenced by training, by chronic altitude exposure, and possibly by the combination of both conditions.
  50. ncbi Consensus statement on chronic and subacute high altitude diseases
    Fabiola Leon-Velarde
    Cayetano Heredia University IIA, Department of Biological and Physiological Sciences, Oxygen Transport Laboratory, Lima 100, Peru
    High Alt Med Biol 6:147-57. 2005
    ..by the International Society for Mountain Medicine (ISMM) at the VI World Congress on Mountain Medicine and High Altitude Physiology (Xining, China; 2004) and represents the committee's interpretation of the current knowledge with ..
  51. ncbi "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance
    B D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas 75231, Dallas, Texas 75235, USA
    J Appl Physiol (1985) 83:102-12. 1997
    The principal objective of this study was to test the hypothesis that acclimatization to moderate altitude (2,500 m) plus training at low altitude (1,250 m), "living high-training low," improves sea-level performance in well-trained ..
  52. ncbi Risk mapping of visceral leishmaniasis: the role of local variation in rainfall and altitude on the presence and incidence of kala-azar in eastern Sudan
    Dia Eldin A Elnaiem
    Department of Zoology, Faculty of Science, University of Khartoum, Sudan
    Am J Trop Med Hyg 68:10-7. 2003
    ..for environmental variables of 190 villages in Gedaref State, including rainfall, vegetation status, soil type, altitude, distance from river, topography, wetness indexes, and average rainfall estimates...
  53. ncbi Prevalence of COPD in five Colombian cities situated at low, medium, and high altitude (PREPOCOL study)
    Andrés Caballero
    Asociación Colombiana de Neumología y Cirugía de Tórax, Clinica Reina Sofia, Bogota, Colombia
    Chest 133:343-9. 2008
    The prevalence of COPD in Colombia is unknown. This study aimed to investigate COPD prevalence in five Colombian cities and measure the association between COPD and altitude.
  54. ncbi Muscle tissue adaptations to hypoxia
    H Hoppeler
    Department of Anatomy, University of Bern, Buhlstrasse 26, CH 3000 Bern 9, Switzerland
    J Exp Biol 204:3133-9. 2001
    ..It was hypothesized in early reports that chronic hypoxia, as the main physiological stress during exposure to altitude, per se might positively affect muscle oxidative capacity and capillarity...
  55. ncbi Arterial blood gases and oxygen content in climbers on Mount Everest
    Michael P W Grocott
    Centre for Altitude, Space, and Extreme Environment Medicine, University College London Institute of Human Health and Performance, London, United Kingdom
    N Engl J Med 360:140-9. 2009
    ..We performed direct field measurements of arterial blood gases in climbers breathing ambient air on Mount Everest...
  56. ncbi Effect of altitude on football performance
    B D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center at Dallas, Texas 75231, USA
    Scand J Med Sci Sports 18:76-84. 2008
    b>Altitude will impact football performance through two separate and parallel pathways related to the hypobaric (physical) and hypoxic (physiological) components of terrestrial altitude: (a) the decrease in partial pressure of oxygen ..
  57. ncbi Impact of a century of climate change on small-mammal communities in Yosemite National Park, USA
    Craig Moritz
    Museum of Vertebrate Zoology, University of California, Berkeley, CA 94720, USA
    Science 322:261-4. 2008
    ..Elevational replacement among congeners changed because species' responses were idiosyncratic. Though some high-elevation species are threatened, protection of elevation gradients allows other species to respond via migration...
  58. ncbi Air to muscle O2 delivery during exercise at altitude
    Jose A L Calbet
    Department of Physical Education, University of Las Palmas de Gran Canaria, Spain
    High Alt Med Biol 10:123-34. 2009
    ..During exercise in hypoxia, diffusion limitation explains most of the additional Pao2-Pao2. With altitude, acclimatization exercise (Pao2-Pao2) is reduced, but does not reach the low values observed in high altitude ..
  59. ncbi Austrian Moderate Altitude Study 2000 (AMAS 2000). The effects of moderate altitude (1,700 m) on cardiovascular and metabolic variables in patients with metabolic syndrome
    Wolfgang Schobersberger
    Klinische Abteilung für Allgemeine und Chirurgische Intensivmedizin der Klinik für Anästhesie und Intensivmedizin, 6020 Innsbruck, Austria
    Eur J Appl Physiol 88:506-14. 2003
    ..Baseline investigations were performed at Innsbruck (500 m above sea level). During the 3-week altitude stay the participants simulated a holiday with moderate sports activities...
  60. ncbi Effect of altitude on football performance: analysis of the 2010 FIFA World Cup Data
    George P Nassis
    Department of Sport Medicine and Biology of Exercise, Faculty of Physical Education and Sport Science, National and Kapodistrian University of Athens, Athens, Greece
    J Strength Cond Res 27:703-7. 2013
    Laboratory studies show that altitude ascent impairs endurance performance. Limited data exist on football, and information from official matches is very scarce even for other team sports...
  61. ncbi Short-term hematological effects upon completion of a four-week simulated altitude camp
    Torben Pottgiesser
    Department of Sports Medicine, University Hospital of Freiburg, Freiburg, Germany
    Int J Sports Physiol Perform 7:79-83. 2012
    ..mass (tHb) is considered to be a main factor for sea-level performance after "live high-train low" (LHTL) altitude training, but little research has focused on the persistence of tHb following cessation of altitude exposure...
  62. ncbi Explorative genome scan to detect candidate loci for adaptation along a gradient of altitude in the common frog (Rana temporaria)
    Aurelie Bonin
    Laboratoire d Ecologie Alpine, CNRS UMR 5553, Universite Joseph Fourier, Grenoble, France
    Mol Biol Evol 23:773-83. 2006
    ..This study investigated the genetic frame of adaptation to a gradient of altitude in the common frog (Rana temporaria) by means of a genome scan based on 392 amplified fragment length ..
  63. ncbi Weight loss at high altitude: pathophysiology and practical implications
    Noor Hamad
    Green College and Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK
    Eur J Gastroenterol Hepatol 18:5-10. 2006
    Climbers at high altitude (>5000 m) lose weight. This impairs performance and safety, but the mechanisms are not entirely due to an imbalance between energy intake and expenditure...
  64. ncbi The effect of acute simulated moderate altitude on power, performance and pacing strategies in well-trained cyclists
    Sally A Clark
    Department of Physiology, Australian Institute of Sport, Canberra, ACT, Australia
    Eur J Appl Physiol 102:45-55. 2007
    Athletes regularly compete at 2,000-3,000 m altitude where peak oxygen consumption (VO2peak) declines approximately 10-20%...
  65. ncbi Physiology and pathophysiology with ascent to altitude
    Biff F Palmer
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Am J Med Sci 340:69-77. 2010
    With increasing altitude, there is a fall in barometric pressure and a progressive fall in the partial pressure of oxygen...
  66. ncbi The altitude-for-latitude disparity in the range retractions of woody species
    Alistair S Jump
    School of Biological and Environmental Sciences, University of Stirling, Stirling, FK9 4LA, UK
    Trends Ecol Evol 24:694-701. 2009
    ..into a approximately 10-km latitudinal retreat based on the rate at which temperatures decline with increasing altitude and latitude, yet reports of latitudinal range retractions are sparse...
  67. ncbi Mitogenomic analysis of Chinese snub-nosed monkeys: Evidence of positive selection in NADH dehydrogenase genes in high-altitude adaptation
    Li Yu
    Laboratory for Conservation and Utilization of Bio resource and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, 650091, PR, China
    Mitochondrion 11:497-503. 2011
    ..the subfamily Colobinae (or leaf-eating monkeys), these endangered primates are unique in being adapted to a high altitude environment and display a remarkable ability to tolerate low temperatures and hypoxia...
  68. ncbi The high-altitude brain
    T F Hornbein
    Department of Anesthesiology, University of Washington, Seattle, WA 98195, USA
    J Exp Biol 204:3129-32. 2001
    ..physiological mechanisms that might cause or contribute to both decrements in real-time performance while at altitude and residual deficits for a time after return to low elevations; the effects of hypoxia on brain cells are an ..
  69. ncbi Altitude ammonia-oxidizing bacteria and archaea in soils of Mount Everest
    Li Mei Zhang
    State Key Laboratory of Urban and Regional Ecology, Research Centre for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, China
    FEMS Microbiol Ecol 70:52-61. 2009
    ..Archaeal amoA abundance was greater than bacterial amoA abundance in lower altitude soils (<or=5400 m a.s.l.), but this situation was reversed in higher altitude soils (>or=5700 m a.s.l.)...
  70. pmc Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates
    Jay F Storz
    School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
    J Exp Biol 213:4125-36. 2010
    High-altitude environments provide ideal testing grounds for investigations of mechanism and process in physiological adaptation...
  71. pmc Altitude-dependent Bartonella quintana genotype C in head lice, Ethiopia
    Emmanouil Angelakis
    Universite de la Mediterranee, Marseille, France
    Emerg Infect Dis 17:2357-9. 2011
    ..B. quintana was found in 19 (7%) genotype C head lice and in 76 (18%) genotype A body lice. B. quintana in head lice was positively linked to altitude (p = 0.014).
  72. ncbi Effect of topography on the risk of malaria infection in the Usambara Mountains, Tanzania
    M J Balls
    School of Biological and Biomedical Sciences, Science Laboratories, South Road, Durham DH1 3LE, UK
    Trans R Soc Trop Med Hyg 98:400-8. 2004
    ..Univariate analysis showed that the risk of splenomegaly declined with increasing altitude and with decreasing potential for water to accumulate...
  73. pmc Topography and malaria transmission heterogeneity in western Kenya highlands: prospects for focal vector control
    Andrew K Githeko
    Climate and Human Health Research Unit, Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
    Malar J 5:107. 2006
    ..The aim of this study was to determine the effects of topography on malaria spatial vector distribution and parasite prevalence...
  74. ncbi Introduced Plasmodium vivax malaria in a Bolivian community at an elevation of 2,300 meters
    Tina Rutar
    Harvard Medical School, Boston, Massachusetts, USA
    Am J Trop Med Hyg 70:15-9. 2004
    ..This outbreak demonstrates the vulnerability of highland populations with poor access to health care to introduced malaria...
  75. ncbi Chest ultrasonography for the diagnosis and monitoring of high-altitude pulmonary edema
    Peter J Fagenholz
    MFA, Department of Emergency Medicine, Clinics 115, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02140, USA
    Chest 131:1013-8. 2007
    ..This is the first report describing its use for the diagnosis and monitoring of high-altitude pulmonary edema (HAPE), the leading cause of death from altitude illness.
  76. ncbi Fasciola hepatica and lymnaeid snails occurring at very high altitude in South America
    S Mas-Coma
    Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Burjassot Valencia, Spain
    Parasitology 123:S115-27. 2001
    ..singular epidemiological characteristics of human fascioliasis is the link of the hyperendemic areas to very high altitude regions, at least in South America...
  77. ncbi Child health and living at high altitude
    S Niermeyer
    University of Colorado School of Medicine, Department of Pediatrics Neonatology, The Children s Hospital, Denver, Colorado 80218 1088, USA
    Arch Dis Child 94:806-11. 2009
    The health of children born and living at high altitude is shaped not only by the low-oxygen environment, but also by population ancestry and sociocultural determinants...
  78. pmc Changing patterns of clinical malaria since 1965 among a tea estate population located in the Kenyan highlands
    G D Shanks
    US Army Medical Research Unit Kenya
    Trans R Soc Trop Med Hyg 94:253-5. 2000
    ..The coincident arrival of chloroquine resistance during the late 1980s in the subregion suggests that drug resistance is a key factor in the current pattern and burden of malaria among this highland population...
  79. ncbi High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein
    G Hartmann
    Ludwig Maximilians University, Munich, Germany
    Cytokine 12:246-52. 2000
    Hypoxic pulmonary vasoconstriction is associated with but may not be sufficient for the development of high-altitude pulmonary oedema (HAPO). Hypoxia is known to induce an inflammatory response in immune cells and endothelial cells...
  80. ncbi Terrestrial insects along elevation gradients: species and community responses to altitude
    Ian D Hodkinson
    School of Biological and Earth Sciences, Liverpool John Moores University, Byrom St, Liverpool L3 3AF, UK
    Biol Rev Camb Philos Soc 80:489-513. 2005
    ..awareness that such responses may serve as analogues for climate warming effects occurring at a particular fixed altitude or latitude over time...
  81. ncbi Continuous positive airway pressure increases haemoglobin O2 saturation after acute but not prolonged altitude exposure
    Piergiuseppe Agostoni
    Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia, Universita di Milano, Via Parea 4, 20138 Milan, Italy
    Eur Heart J 31:457-63. 2010
    It is unknown whether subclinical high-altitude pulmonary oedema reduces spontaneously after prolonged altitude exposure...
  82. ncbi Transpulmonary plasma ET-1 and nitrite differences in high altitude pulmonary hypertension
    Marc M Berger
    Department of Anesthesiology, University of Heidelberg, Germany
    High Alt Med Biol 10:17-24. 2009
    ..Swenson. Transpulmonary plasma ET-1 and nitrite differences in high altitude pulmonary hypertension. High Alt. Med. Biol. 10:17-24, 2009...
  83. ncbi Clinical features of headache at altitude: a prospective study
    E Silber
    King s Regional Neuroscience Center, London, UK
    Neurology 60:1167-71. 2003
    Headache is the most common nervous system complication at altitude; however, there have been few attempts to characterize clinical features of high-altitude headaches (HAH).
  84. pmc Structural modifications of the brain in acclimatization to high-altitude
    Jiaxing Zhang
    Laboratory for Higher Brain Function, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 5:e11449. 2010
    Adaptive changes in respiratory and cardiovascular responses at high altitude (HA) have been well clarified. However, the central mechanisms underlying HA acclimatization remain unclear...
  85. ncbi Hypobaric hypoxia causes body weight reduction in obese subjects
    Florian J Lippl
    Division of Gastroenterology, Department of Internal Medicine, University Hospital of Ludwig Maximilians University, Munich, Germany
    Obesity (Silver Spring) 18:675-81. 2010
    ..The aim of our study was to examine the effect of hypobaric hypoxia on body weight at high altitude in obese subjects. We investigated 20 male obese subjects (age 55.7 +/- 4.1 years, BMI 33.7 +/- 1.0 kg/m(2))...
  86. ncbi Visual control of altitude in flying Drosophila
    Andrew D Straw
    Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA
    Curr Biol 20:1550-6. 2010
    ..of the visual reflexes that regulate horizontal course, the sensory-motor mechanisms that animals use to control altitude are poorly understood...
  87. ncbi Endocrine and metabolic responses to extreme altitude and physical exercise in climbers
    Andrea Benso
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Molinette Hospital, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy
    Eur J Endocrinol 157:733-40. 2007
    Chronic hypoxia induces complex metabolic and endocrine adaptations. High-altitude (HA) exposure is a physiological model of hypoxia.
  88. ncbi Reduced autonomic activity during stepwise exposure to high altitude
    K Sevre
    Department of Cardiology, , Oslo, Norway
    Acta Physiol Scand 173:409-17. 2001
    ..a recent field study we found reduced plasma catecholamines during the first days after a stepwise ascent to high altitude. In the present study 14 subjects were exposed to a simulated ascent in a hypobaric chamber to test the ..
  89. ncbi Mobile carbohydrates in Himalayan treeline trees I. Evidence for carbon gain limitation but not for growth limitation
    Mai He Li
    Swiss Federal Institute for Forest, Snow and Landscape Research WSL, Zuercherstrasse 111, Birmensdorf, Switzerland
    Tree Physiol 28:1287-96. 2008
    ..For comparison, we investigated a low-altitude species (Tsuga yunnanensis (Franch.) Pritz...
  90. ncbi Timing and duration of European larch growing season along altitudinal gradients in the Swiss Alps
    Lea Moser
    Institute of Geography, Climatology and Meteorology Research Group, University of Bern, Hallerstrasse 12, CH 3012 Bern, Switzerland
    Tree Physiol 30:225-33. 2010
    ..changed by 3-4 days per 100 m elevation; the ending of the growing season, however, appeared minimally related to altitude. If associated with the monitored altitudinal lapse rate of -0...
  91. ncbi Breathing patterns and cardiovascular autonomic modulation during hypoxia induced by simulated altitude
    L Bernardi
    Department of Internal Medicine, University of Pavia and IRCCS S. Matteo, Italy
    J Hypertens 19:947-58. 2001
    ..the influence of different breathing patterns on autonomic cardiovascular modulation during acute exposure to altitude-induced hypoxia...
  92. ncbi Human behaviour and development under high-altitude conditions
    Javier Virues-Ortega
    Department of Personality, Assessment and Treatment, Universidad de Granada, Spain
    Dev Sci 9:400-10. 2006
    Although we are far from a universally accepted pattern of impaired function at altitude, there is evidence indicating motor, perceptual, memory and behavioural deficits in adults...
  93. ncbi The carbon charging of pines at the climatic treeline: a global comparison
    Günter Hoch
    Institute of Botany, University of Basel, Schönbeinstrasse 6, 4056 Basel, Switzerland
    Oecologia 135:10-21. 2003
    ..It seems rather that low temperatures directly affect sink activity at the treeline, with surplus carbon stored in osmotically inactive compounds...
  94. ncbi Population structure of Columbia spotted frogs (Rana luteiventris) is strongly affected by the landscape
    W Chris Funk
    Division of Biological Sciences, University of Montana, Missoula, Montana 59812, USA
    Mol Ecol 14:483-96. 2005
    ..Our results show that landscape features have a profound effect on patterns of genetic variation in Columbia spotted frogs...
  95. ncbi Intraocular pressure during a very high altitude climb
    Martina M Bosch
    Department of Ophthalmology, University Hospital, Zurich, Switzerland
    Invest Ophthalmol Vis Sci 51:1609-13. 2010
    ..Reports on intraocular pressure (IOP) changes at high altitudes have provided inconsistent and even conflicting..
  96. ncbi Low larval vector survival explains unstable malaria in the western Kenya highlands
    C J M Koenraadt
    Laboratory of Entomology, Department of Plant Sciences, Wageningen University, The Netherlands
    Trop Med Int Health 11:1195-205. 2006
    ..and malaria vector survival in a highland area in western Kenya, ranging from approximately 1,550-1,650 m altitude. Although only five adult malaria vectors were collected during 180 light traps and 180 resting collections over ..
  97. ncbi New insights into ocular blood flow at very high altitudes
    Martina M Bosch
    Department of Opthamology, University Hospital, Zurich, Switzerland
    J Appl Physiol (1985) 106:454-60. 2009
    ..flow resulting from altered autoregulation constitutes a risk factor for acute mountain sickness (AMS) and high-altitude cerebral edema (HACE) by leading to capillary overperfusion and vasogenic cerebral edema...
  98. pmc New highland distribution records of multiple Anopheles species in the Ecuadorian Andes
    Lauren L Pinault
    Department of Biological Sciences, Brock University, F211 Mackenzie Chown Complex, 500 Glenridge Avenue, St, Catharines, Canada, L2S 3A1
    Malar J 10:236. 2011
    ..This study attempts to expand the current knowledge of the distribution of common Anopheles species in Ecuador, with particular attention to highland regions (> 500 m) of the Andes...
  99. pmc On the origin of Tibetans and their genetic basis in adapting high-altitude environments
    Binbin Wang
    National Research Institute for Family Planning, Beijing, People s Republic of China
    PLoS ONE 6:e17002. 2011
    ..Most of these genes were highly correlated with population-specific and beneficial phenotypes, such as high infant survival rate and the absence of chronic mountain sickness...
  100. pmc Environmental, socio-demographic and behavioural determinants of malaria risk in the western Kenyan highlands: a case-control study
    Kacey C Ernst
    Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
    Trop Med Int Health 14:1258-65. 2009
    ..To identify risk factors for uncomplicated malaria in highland areas of East Africa at higher risk of malaria epidemics, in order to design appropriate interventions...
  101. ncbi Scale effects and human impact on the elevational species richness gradients
    D Nogués-Bravo
    Department of Biodiversity and Evolutionary Biology, National Museum of Natural Sciences, CSIC, c Jose Gutierrez Abascal, 2, 28006 Madrid, Spain
    Nature 453:216-9. 2008
    ....

Research Grants63

  1. ECG-derived cardiopulmonary coupling biomarkers of sleep, sleep-breathing, and ca
    Robert J Thomas; Fiscal Year: 2010
    ..e., metronomic oscillations with a relatively fixed frequency). Narrow band e-LFC is induced by high altitude, heart failure, and predicts central apnea induction during positive pressure titration...
  2. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..The average altitude of these states is above 4000 ft...
  3. (INTRODUCTION) MECHANISMS OF ACCLIMATIZATION: FETUS AND ADULT
    Lawrence D Longo; Fiscal Year: 2013
    ..theme of this application is to explore fundamental mechanisms whereby the fetus and adult acclimatize to high altitude, long-term hypoxia (LTH)...
  4. ANDV Induced Responses of Hypoxic Endothelial Cells
    Erich R Mackow; Fiscal Year: 2012
    ..Hypoxia induces high altitude pulmonary edema through the induction of vascular endothelial growth factor (VEGF), and this response is ..
  5. International Training and Research in Environmental and Occupational Health
    NELSON K STEENLAND; Fiscal Year: 2012
    ..An additional specific problem in Peru and Chile is altitude sickness. In important percentage of the population in both these countries live in high altitude...
  6. IRS insecticides for malaria control and child neurodevelopment in South Africa
    Brenda Eskenazi; Fiscal Year: 2013
    ..We take advantage of a natural experiment where gradations in altitude impact mosquito survival and, by extension, use of IRS, but sprayed and unsprayed villages are otherwise similar, ..
  7. Intrauterine chronic hypoxia and ryanodine receptors in fetal pulmonary arteries
    Sean M Wilson; Fiscal Year: 2013
    ..Maternal hypoxemia due to high altitude living, placental insufficiency, and smoking puts infants of certain populations at risk o developing pulmonary ..
  8. Intrauterine hypoxia induces cytokine gene expression in fetal cardiac ventricles
    LASHAUNA C EVANS; Fiscal Year: 2010
    ..Fetuses may be exposed to hypoxia if the mother lives at high altitude, smokes, or is subject to intrauterine stress such as preeclampsia, uterine ischemia, or placental dysfunction...
  9. Evolved placental response to hypoxa
    Stacy Zamudio; Fiscal Year: 2012
    ..The 4-group research design compares Andeans (altitude-adapted for ~8000 yr) versus altitude-naove (European) groups living at high versus low altitude...
  10. Mechanisms of Hemoglobin Adaptation to Hypoxia in High-altitude Rodents
    Jay F Storz; Fiscal Year: 2012
    ..purpose of the proposed research project is to elucidate the molecular basis of physiological adaptation to high-altitude hypoxia, a condition resulting from a reduced supply of oxygen to the cells of respiring tissues...
  11. Hypoxia and Aberrant Uterine Vascular Adaptation in Pregnancy
    Lubo Zhang; Fiscal Year: 2013
    ..Three specific aims are proposed to determine whether: 1) long-term high altitude hypoxia during gestation increases the promoter methylation resulting in ER1 gene repression, 2) prolonged ..
  12. Mechanisms &Effects of Prenatal Maternal Affect on Pregnancy &Infant Development
    Christine Dunkel Schetter; Fiscal Year: 2013
    ..of its involvement in inflammation, mood disorders, and birth outcome;(2) if and how residence at moderate altitude (5280 feet above sea level) may play a role in these effects;and (3) how prenatal maternal biopsychosocial ..
  13. Imaging Nonlinear Control of the Pulmonary Circulation with Proton MRI
    Susan R Hopkins; Fiscal Year: 2013
    ..healthy human subjects and those with a known abnormality of the pulmonary circulation-previous sufferers of high altitude pulmonary edema (HAPE). In HAPE a previously healthy individual, develops a florid pulmonary edema at altitude...
  14. Air Pollution, Systemic Inflammation, and Sub-Clinical Atherosclerosis in High-Al
    RODRIGO XAVIER ARMIJOS; Fiscal Year: 2010
    ..in 300 children (age 7-12 yrs) residing in the Quito Metropolitan District (QMD), a heavily polluted, high altitude city that has distinct PM gradients among neighborhoods...
  15. Endothelial BK Channels and Vasoreactivity Following Chronic Hypoxia
    Benjimen R Walker; Fiscal Year: 2013
    ..by applicant): Chronic hypoxia (CH) results from pulmonary disorders such as COPD and from residence at high altitude. CH elicits a variety of responses within the cardiovascular system...
  16. A murine model for placental metabolic reprogramming
    Nicholas P Illsley; Fiscal Year: 2013
    ..We have used a unique human model of chronic (altitude-induced) hypoxia to show that despite a substantial decrement in maternal arterial oxygen tension, hypoxia is not ..
  17. Integrating physiological and genetic mechanisms of body size regulation
    Viviane Callier; Fiscal Year: 2013
    ..the potential to explain phenomena such as why many species, including humans, have smaller body sizes at high altitude (low oxygen conditions)...
  18. Health Revolutionary: The Life and Science of Ancel Keys
    Sarah W Tracy; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Evolutionary biologist, high altitude expedition leader, developer of the K- Ration, pioneer in the study of human starvation and rehabilitation, architect of the National Science Foundation, ..
  19. Adaptive evolution of gene expression in Drosophila melanogaster
    JUSTIN BRITT LACK; Fiscal Year: 2013
    ..Heritable phenotypic differences in cold tolerance between pairs of low- and high-altitude (and latitude) populations collected from Africa and Europe have already been identified and the range of genomic ..
  20. Brain Chemistry and Altitude in Bipolar Disorder
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2013
    ..One such environmental factor may be altitude. Extreme altitudes are associated with a decreased partial pressure of inspired oxygen, and this hypobaric ..
  21. Nitrite and Hypoxia Increase Mitochondrial Biogenesis and Insulin Sensitivity
    CHRISTOPHER P O'DONNELL; Fiscal Year: 2013
    ..We have recently, and unexpectedly, found that chronic adaptation to continuous hypoxia (CH;i.e. simulating altitude exposure) can increase insulin sensitivity in lean mice...
  22. Stimulation Induced Modulation of Sleep
    MATTHEW TARLER; Fiscal Year: 2009
    ..The carotid bodies are critical for ventilatory acclimatization to high altitude, and contribute in part to exercise-induced hyperventilation, and are critical for the generation of periodic ..
  23. Genome-Wide Analysis of Adaptive Evolution in Humans
    JOSHUA MICHAEL AKEY; Fiscal Year: 2010
    ..that selected allele and haplotype frequencies are correlated with environmental attributes such as latitude, altitude, or climate. The data generated in this project will have a significant impact on public health...
  24. Mechanisms of RET/PTC Rearrangement in Thyroid Cancer
    Yuri E Nikiforov; Fiscal Year: 2013
    ..volume of diagnostic and therapeutic radiation, nuclear power accidents such as Chernobyl and Fukushima, high altitude travel, and other exposures...
  25. Comprehensive Sun Protection in Recreation: An Advanced Go Sun Smart Program
    PETER ALEX ANDERSEN; Fiscal Year: 2013
    ..Advanced GSS extends our winter high- altitude GSS to spring/ summer environments when UV is highest...
  26. UCSF Clinical Research Center for Prematurity and Respiratory Outcomes Program
    Roberta L Keller; Fiscal Year: 2013
    ..from questionnaires assessing pulmonary symptoms, hospitalizations and medications, and validated by a hypoxic (altitude) challenge test and pulmonary function testing...
  27. Cytoarchitecture of Central Respiratory Afferents Processing
    Gang Song; Fiscal Year: 2013
    ..us to develop better pharmacological treatments for respiratory diseases such as respiratory failure, sudden infant death, sleep apnea, and various other respiratory disorders and to better cope with mountain sickness at high altitude.
  28. Leptin and hypothalamo-pituitary-adrenal function in the long-term hypoxic fetus
    Charles A Ducsay; Fiscal Year: 2013
    ..Our laboratory has developed a model of LTH in which pregnant ewes are maintained at high altitude (3,820 m) resulting in a sustained, moderate hypoxic state from day 30 of gestation onward...
  29. An Autoimmune Basis for Pulmonary Hypertension.
    Mark Nicolls; Fiscal Year: 2009
    ..Preliminary findings demonstrate that severe PH will develop following VEGFR blockade in Denver altitude conditions if administered to experimental animals that lack T cells (i.e...
  30. Youth produced videos to reduce UV exposure in adolescents
    Lori A Crane; Fiscal Year: 2010
    ..cancer, much of the risk is acquired prior to age 20, and Coloradoans are particularly at risk because of high altitude, sunny climate, and an outdoor lifestyle...
  31. Comprehensive Characterization of Intrapulmonary Arteriovenous Pathways in Health
    Marlowe Eldridge; Fiscal Year: 2012
    ..and consequences of inducible intrapulmonary shunt pathways in health, bronchopulmonary dysplasia (BPD) and high altitude pulmonary edema (HAPE)...
  32. Pulmonary vascular control at moderate altitude in patients with type 1 diabetes
    James C Baldi; Fiscal Year: 2010
    ..An increasing number of people type 1 diabetes are participating in adventure activities at moderate or high altitude. Limited data suggests that diabetic individuals may be less 'successful'in these conditions...
  33. GENETIC BASIS OF SPECIES DIFFERENCES IN DROSOPHILA
    Jerry Coyne; Fiscal Year: 2009
    ..santomea mother, and nearly all of them occur at high altitude outside the range of either parental species...
  34. Natural selection and DNA sequence variation in Mus
    Michael W Nachman; Fiscal Year: 2013
    ..The sampling design includes paired transects for both altitude and latitude...
  35. Blood rheology: analytical approaches to sickle cell disease
    Lance Munn; Fiscal Year: 2009
    ..This is a precarious situation, because slight changes in physiology (e.g. oxygen demand during exercise, high altitude) can catalyze a "painful crisis" in which low oxygen levels encourage cell sickling which further increases flow ..
  36. Lung Perfusion Heterogeneity and Mechanisms of Edema
    Susan R Hopkins; Fiscal Year: 2010
    ..High altitude pulmonary edema (HAPE), an acute potentially fatal edema is used as a disease model, to allow investigation of ..
  37. Pontomedullary Integration of Respiratory Afferents
    Chi Sang Poon; Fiscal Year: 2010
    ..certain at-risk subject populations, such as congestive heart failure patients and individuals sleeping at high altitude. PUBLIC HEALTH RELEVANCE: Breathing is a vital bodily function that is fundamental to life...
  38. CHEMOSENSITIVITY, UPPER AIRWAY--BREATHING
    Kevin Gleeson; Fiscal Year: 1991
    ..produced in response to hypoxia or hypercapnia (airway obstruction (sleep apnea) or hypoxic environment (altitude)) may yield hypocapnia and apnea with cycling ventilation...
  39. PO2 MODULATION OF NO AND ET1 IN PULMONARY HYPERTENSION
    Karen Fagan; Fiscal Year: 2002
    ..We will also report the development of PHT in eNOS knock-out mice at mild hypoxia (Denver's altitude) compared to controls, which is attenuated by conditions equivalent to sea level...
  40. Spatial-Temporal Dynamics of Blood Flow in the Normal Human Lung
    GORDON KIM PRISK; Fiscal Year: 2013
    ..the effects of ageing;and 4) the effects of altered O2 and CO2 in the lungs of subjects susceptible to high altitude pulmonary edema...
  41. Dissociating hypoxia from pathology in preeclampsia and*
    Stacy Zamudio; Fiscal Year: 2007
    ..The parent grant, "Altitude-Induced Hypoxia, Intrauterine Growth Restriction (IUGR) and Placental Development" uses a unique natural ..
  42. INFLUENCE OF ACID-BASE STATUS ON FLUORIDE METABOLISM
    GARY WHITFORD; Fiscal Year: 1992
    ..It has been found that hypobaric hypoxia (simulated high altitude) increases the retention of fluoride and that it causes disturbances in enamel mineralization that resemble ..
  43. Tissue Oxygenation and Cerebral Vulnerability to Hypoxia
    David Dubowitz; Fiscal Year: 2013
    ..During our recent studies investigating cerebral acclimatization to high altitude in human subjects, we found that Cerebral O2 metabolism (CMRO2) increases during hypoxia despite reduced O2 ..
  44. Acoustic Measurement of Bubbles in Biological Media
    Georges Chahine; Fiscal Year: 2006
    ..pressure associated with termination of hyperbaric oxygen treatment, ascent of divers, pilots undergoing high-altitude high-g maneuvers or astronauts undergoing extra-vehicular activities...
  45. LUNG GROWTH AT HIGH ALTITUDE AND MAXIMAL O2 TRANSPORT
    Robert Johnson; Fiscal Year: 2005
    DESCRIPTION (Applicant's abstract): Human natives of high altitude (HA) develop increased lung volume and diffusing capacity consistent with enhanced alveolar growth, and increase blood volumes that facilitate 02 transport...
  46. Influences of hypoxia on noise induced hearing loss
    Guang Di Chen; Fiscal Year: 2003
    ..People may suffer from insufficient blood oxygen supply due to pulmonary or cardiovascular disease, altitude, and environmental pollution by chemical asphyxiates...
  47. GABA-A receptor plasticity: regulation by hypoxia
    RUTH SIEGEL; Fiscal Year: 2009
    ..to define molecular mechanisms used in adapting to reduced oxygen, a stress that occurs physiologically at high altitude and in several pathological conditions, including chronic obstructive pulmonary diseases...
  48. MODELS OF HYPOXIC PULMONARY HYPERTENSION
    Archibald Alexander; Fiscal Year: 1980
    Airway hypoxia of the lung resulting from high altitude exposure and a number of cardiopulmonary diseases leads to pulmonary vascular constriction, pulmonary hypertension and sometimes, right heart failure...
  49. Time Domains of Sympathetic Activity following Hypoxia
    James Weiss; Fiscal Year: 2006
    ..characterizing the time domains and the mechanisms of SNA after hypoxic exposure, these studies will have implications for normal physiology (altitude acclimatization) and for pathophysiology (obstructive sleep apnea).
  50. EFFECT OF VIRUS AND HYPOXIA ON LUNG ENDOTHELIN AND EDEMA
    Todd Carpenter; Fiscal Year: 2004
    Although high-altitude pulmonary edema has been the topic of research activity for a number of years, the basic mechanisms contributing to its formation remain incompletely understood...
  51. NEUROPEPTIDASES AND CAROTID BODY FUNCTIONS
    Ganesh Kumar; Fiscal Year: 2000
    ..These studies may also yield new information in the development of enzyme based therapeutic agents in the treatment of hypoxemia, associated with high altitude adaptation and chronic obstructive lung diseases.
  52. ALTITUDE ADAPTATION IN CHRONIC LUNG DISEASE
    William Graham; Fiscal Year: 1980
    ..is designed to study the adaptation of patients with chronic obstructive lung disease who are transported to an altitude of 6300 feet for a period of three days...
  53. Lung Growth in Infants and Toddlers Residing at High Altitude
    Robert S Tepper; Fiscal Year: 2010
    ..Conrado Llapur, as an extension of NIH grant R01 HL054062. Young children and adults residing at high altitude since birth have larger lungs than subjects residing at sea-level...
  54. DETERMINANTS OF THE VENTILATORY RESPONSE TO HYPOXIA
    Norman Edelman; Fiscal Year: 1999
    ..threatened in situations as diverse as acute and chronic lung disease, cardiovascular disease and ascent to high altitude. These responses are not independent variables but interact substantially with each other...
  55. INTRAUTERINE GROWTH RESTRICTION AT HIGH ALTITUDES
    LORNA MOORE; Fiscal Year: 2001
    ..a unique environment (altitudes as high as 4800 m), unique populations (persons of multi-generational high-altitude ancestry and lifelong residents or recent migrants of low-altitude ancestry), and involves more extensive use of ..
  56. Excercise induced rise in Severity of Altitude Illness
    Robert Roach; Fiscal Year: 2004
    ..incurs significant medical risks and costs since as many as 5 percent of cases can develop life-threatening high altitude cerebral edema (HACE)...
  57. ADAPTATION TO ENVIRONMENTAL STRESS--MECHANISTIC ANALYSES
    James Whitlock; Fiscal Year: 2000
    ..Hypoxia occurs under physiological conditions (high altitude) and in disease states (cancer, ischemia, anemia)...
  58. VASCULAR ENDOTHELIAL FUNCTION DURING SYSTEMIC HYPOXIA
    John Wood; Fiscal Year: 2003
    ..response to ischemia/reperfusion has been studied extensively, the effects of systematic hypoxia such as altitude exposure and acute and chronic pulmonary disease...
  59. REGIONAL CONTROLLERS OF PULMONARY GAS EXCHANGE
    Jose Venegas; Fiscal Year: 2000
    ..will have direct clinical applications such as in the management of hypoxemia during pulmonary embolism high altitude pulmonary edema...
  60. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2007
    ..identification of stress failure has clarified various aspects of human pathology such as the mechanism of high-altitude pulmonary edema, and the damage to pulmonary capillaries caused by high states of lung inflation...
  61. ANATOMICAL, BREATHING AND ALTITUDE VARIABLES IN SIDS
    ARLENE FRAIKOR; Fiscal Year: 1980
    ..To accomplish this, anatomical, behavioral, medical, familial and altitude variables are being investigated...
  62. PATHOPHYSIOLOGICAL EFFECTS OF HYPOXIA
    LO CHANG OU; Fiscal Year: 1993
    ..CH is seen in man living at high altitude (HA) and also occurs in patients suffering from heart or lung dysfunction...
  63. AERODYNAMIC VALVING AND VENTILATION
    Robert Banzett; Fiscal Year: 1993
    ..Normal activities such as exercise, flight, performance at altitude, thermal stress and panting and vocalization each present a unique challenge to the avian respiratory system...