- The use of 'altitude' in ecological research
Institute of Botany, University of Basel, Schönbeinstrasse 6, Basel, CH 4056, Switzerland
Trends Ecol Evol 22:569-74. 2007
..However, there are two categories of environmental changes with altitude: those physically tied to meters above sea level, such as atmospheric pressure, temperature and clear-sky ..
- Sequencing of 50 human exomes reveals adaptation to high altitude
BGI Shenzhen, Shenzhen 518083, China
Science 329:75-8. 2010
Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18x per individual...
- Genetic evidence for high-altitude adaptation in Tibet
Tatum S Simonson
Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
Science 329:72-5. 2010
..that reveal positive selection in several regions that contain genes whose products are likely involved in high-altitude adaptation...
- The yak genome and adaptation to life at high altitude
State Key Laboratory of Grassland Agro Ecosystem, College of Life Science, Lanzhou University, Lanzhou, China
Nat Genet 44:946-9. 2012
Domestic yaks (Bos grunniens) provide meat and other necessities for Tibetans living at high altitude on the Qinghai-Tibetan Plateau and in adjacent regions...
- Enhancing team-sport athlete performance: is altitude training relevant?
School of Sport and Exercise Science, Institute of Sport, Exercise and Active Living ISEAL, Victoria University, Melbourne, Vic, Australia
Sports Med 42:751-67. 2012
..Matches may also be played at moderate altitude where the lower oxygen partial pressure exerts a detrimental effect on performance...
- A genome-wide search for signals of high-altitude adaptation in Tibetans
Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Mol Biol Evol 28:1003-11. 2011
..in the world, may offer a unique opportunity to understand the biological adaptations of human beings to high-altitude environments...
- Influence of cerebral and muscle oxygenation on repeated-sprint ability
Kurt J Smith
Integrative Physiology Unit, University of Lethbridge, Lethbridge, AB, Canada
Eur J Appl Physiol 109:989-99. 2010
..By using a hypoxia paradigm, the study suggests that cerebral oxygenation contributes to the impairment of repeated-sprint ability...
- A significant upward shift in plant species optimum elevation during the 20th century
AgroParisTech, UMR 1092, Laboratoire d Etude des Ressources Forêt Bois LERFoB, 14 rue Girardet, F 54000 Nancy, France
Science 320:1768-71. 2008
..Our study shows that climate change affects the spatial core of the distributional range of plant species, in addition to their distributional margins, as previously reported...
- Effect of short-term acclimatization to high altitude on sleep and nocturnal breathing
Pulmonary Division and Sleep Disorders Center, University Hospital of Zurich, and Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
Sleep 35:419-23. 2012
Objective physiologic data on sleep and nocturnal breathing at initial exposure and during acclimatization to high altitude are scant...
- The effects of classic altitude training on hemoglobin mass in swimmers
N B Wachsmuth
Department of Sports Medicine Sports Physiology, University of Bayreuth, 95440 Bayreuth, Germany
Eur J Appl Physiol 113:1199-211. 2013
Aim of the study was to determine the influence of classic altitude training on hemoglobin mass (Hb-mass) in elite swimmers under the following aspects: (1) normal oscillation of Hb-mass at sea level; (2) time course of adaptation and de-..
- Physiological and performance responses to a preseason altitude-training camp in elite team-sport athletes
Blake D McLean
Collingwood Football Club, Melbourne, Australia
Int J Sports Physiol Perform 8:391-9. 2013
Little research has been done on the physiological and performance effects of altitude training on team-sport athletes...
- Global warming, elevational range shifts, and lowland biotic attrition in the wet tropics
Robert K Colwell
Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, CT 06269, USA
Science 322:258-61. 2008
- Sea-level exercise performance following adaptation to hypoxia: a meta-analysis
Darrell L Bonetti
Institute of Sport and Recreation Research, School of Sport and Recreation, AUT University, Auckland, New Zealand
Sports Med 39:107-27. 2009
Adaptation to living or training in hypoxic environments (altitude training) continues to gain interest from sport scientists and endurance athletes...
- Preparation for football competition at moderate to high altitude
C J Gore
Department of Physiology, Australian Institute of Sport, Canberra, Australia
Scand J Med Sci Sports 18:85-95. 2008
..100 years of home-and-away South American World Cup matches illustrate that football competition at moderate/high altitude (>2000 m) favors the home team, although this is more than compensated by the likelihood of sea-level teams ..
- Enhanced AFLP genome scans detect local adaptation in high-altitude populations of a small rodent (Microtus arvalis)
Martin C Fischer
Computational and Molecular Population Genetics, Institute of Ecology and Evolution, University of Bern, Baltzerstrasse 6, Bern, Switzerland
Mol Ecol 20:1450-62. 2011
Adaptation to adverse environmental conditions such as high altitude requires physiological and/or morphological changes...
- Mitochondrial DNA variant associated with Leber hereditary optic neuropathy and high-altitude Tibetans
lnstitute of Human Respiratory Disease, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
Proc Natl Acad Sci U S A 109:7391-6. 2012
..7). In high-altitude Tibetan and Indian populations, the 3394C variant occurs on five different macrohaplogroup M haplogroup ..
- Time course of the hemoglobin mass response to natural altitude training in elite endurance cyclists
Department of Physiology, Australian Institute of Sport, Canberra, Australia
Scand J Med Sci Sports 22:95-103. 2012
To determine the time course of hemoglobin mass (Hb(mass)) to natural altitude training, Hb(mass), erythropoietin [EPO], reticulocytes, ferritin and soluble transferrin receptor (sTfR) were measured in 13 elite cyclists during, and 10 ..
- Natural selection on EPAS1 (HIF2alpha) associated with low hemoglobin concentration in Tibetan highlanders
Cynthia M Beall
Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106 7125, USA
Proc Natl Acad Sci U S A 107:11459-64. 2010
By impairing both function and survival, the severe reduction in oxygen availability associated with high-altitude environments is likely to act as an agent of natural selection...
- Two routes to functional adaptation: Tibetan and Andean high-altitude natives
Cynthia M Beall
Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106, USA
Proc Natl Acad Sci U S A 104:8655-60. 2007
..for natural selection for traits that offset the unavoidable environmental stress of severe lifelong high-altitude hypoxia...
- Spatial clustering of malaria and associated risk factors during an epidemic in a highland area of western Kenya
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
Trop Med Int Health 9:757-66. 2004
..Household geographical location and altitude were determined using a hand-held geographical positioning system and landcover types were determined using high ..
- Long-term outcome after ICD and CRT implantation and influence of remote device follow-up: the ALTITUDE survival study
Leslie A Saxon
University of Southern California, Keck School of Medicine, Cardiovascular and Thoracic Institute, Los Angeles, CA 90033, USA
Circulation 122:2359-67. 2010
..No clinical trial has evaluated mortality after device implantation or after shock therapy in large numbers of patients with implanted devices that regularly transmit device data over a network...
- Neocytolysis on descent from altitude: a newly recognized mechanism for the control of red cell mass
Section of Hematology, Department of Medicine, Baylor College of Medicine, 6565 Fannin, MS 902 Main, Houston, TX 77030, USA
Ann Intern Med 134:652-6. 2001
..Studies of space-flight anemia have uncovered a physiologic process, neocytolysis, by which young red blood cells are selectively hemolyzed, allowing rapid adaptation when red cell mass is excessive for a new environment...
- High altitude adaptation in Daghestani populations from the Caucasus
The Wellcome Trust Sanger Institute, Hinxton, UK
Hum Genet 131:423-33. 2012
We have surveyed 15 high-altitude adaptation candidate genes for signals of positive selection in North Caucasian highlanders using targeted re-sequencing...
- Genetic signatures reveal high-altitude adaptation in a set of ethiopian populations
Department of Integrative Biology, University of California, Berkeley, CA, USA
Mol Biol Evol 30:1877-88. 2013
The Tibetan and Andean Plateaus and Ethiopian highlands are the largest regions to have long-term high-altitude residents. Such populations are exposed to lower barometric pressures and hence atmospheric partial pressures of oxygen...
- Malaria in the African highlands: past, present and future
S W Lindsay
Department of Biological Sciences, University of Durham, England
Bull World Health Organ 76:33-45. 1998
..We further recommend that a regional modelling approach should be adopted to assess the extent and severity of this problem and help improve disease surveillance and the quality of health care delivered in this unstable ecosystem...
- Time course of haemoglobin mass during 21 days live high:train low simulated altitude
Sally A Clark
Department of Physiology, Australian Institute of Sport, PO Box 176, Belconnen, ACT, 2616, Australia
Eur J Appl Physiol 106:399-406. 2009
..Twelve well-trained male cyclists participated in a 3-week LHTL protocol comprising 3,000 m simulated altitude for ~14 h/day...
- Does 'altitude training' increase exercise performance in elite athletes?
Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
Br J Sports Med 46:792-5. 2012
The general practice of altitude training is widely accepted as a means to enhance sport performance despite a lack of rigorous scientific studies...
- Sleep architecture changes during a trek from 1400 to 5000 m in the Nepal Himalaya
Pamela L Johnson
David Read Laboratory, Department of Medicine, University of Sydney, Sydney, NSW 2006, Australia
J Sleep Res 19:148-56. 2010
The aim of this study was to examine sleep architecture at high altitude and its relationship to periodic breathing during incremental increases in altitude...
- Red cell volume expansion at altitude: a meta-analysis and Monte Carlo simulation
Zurich Center of Integrative Human Physiology, Institute of Physiology, Zurich, Switzerland
Med Sci Sports Exerc 45:1767-72. 2013
b>Altitude acclimatization is associated with a rapid increase in hematocrit. The time course and the contribution of the red cell volume expansion are not clear...
- "Live high-train low" using normobaric hypoxia: a double-blinded, placebo-controlled study
Center for Integrative Human Physiology, Institute of Physiology, University of Zurich, Zurich, Switzerland
J Appl Physiol (1985) 112:106-17. 2012
The combination of living at altitude and training near sea level [live high-train low (LHTL)] may improve performance of endurance athletes...
- Genetic adaptation to high altitude in the Ethiopian highlands
Laura B Scheinfeldt
Department of Genetics, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104, USA
Genome Biol 13:R1. 2012
Genomic analysis of high-altitude populations residing in the Andes and Tibet has revealed several candidate loci for involvement in high-altitude adaptation, a subset of which have also been shown to be associated with hemoglobin levels, ..
- Changes in climatic water balance drive downhill shifts in plant species' optimum elevations
Shawn M Crimmins
Department of Forest Management, College of Forestry and Conservation, University of Montana, Missoula, MT 59812, USA
Science 331:324-7. 2011
..Similar downhill shifts can be expected to occur where future climate change scenarios project increases in water availability that outpace evaporative demand...
- The genetic architecture of adaptations to high altitude in Ethiopia
Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America
PLoS Genet 8:e1003110. 2012
..For each ethnic group, we sampled low and high altitude residents, thus allowing genetic and phenotypic comparisons across altitudes and across ethnic groups...
- Living the high life: high-altitude adaptation
Laura B Scheinfeldt
Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
Genome Biol 11:133. 2010
Genome-wide scans demonstrate that genetic variants associated with high-altitude adaptation in Tibetans and Andeans arose independently as a result of convergent adaptation.
- Optimal time of arrival for performance at moderate altitude (1700 m)
A R Weston
Department of Physiology, University of Natal Medical School, Congella, Natal 4013, South Africa
Med Sci Sports Exerc 33:298-302. 2001
The time course of physiological exercise responses after acute ascent to moderate altitude was investigated.
- Effectiveness of intermittent training in hypoxia combined with live high/train low
Eileen Y Robertson
Department of Physiology, Australian Institute of Sport, Canberra, Australia
Eur J Appl Physiol 110:379-87. 2010
Elite athletes often undertake altitude training to improve sea-level athletic performance, yet the optimal methodology has not been established...
- Effect of hypoxic "dose" on physiological responses and sea-level performance
Randall L Wilber
Athlete Performance Laboratory, United States Olympic Committee, Colorado Springs, CO 80909, USA
Med Sci Sports Exerc 39:1590-9. 2007
Live high-train low (LH+TL) altitude training was developed in the early 1990s in response to potential training limitations imposed on endurance athletes by traditional live high-train high (LH+TH) altitude training...
- Update on high-altitude pulmonary edema: pathogenesis, prevention, and treatment
Joshua O Stream
Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA
Wilderness Environ Med 19:293-303. 2008
High-altitude pulmonary edema (HAPE) is a life-threatening noncardiogenic form of pulmonary edema (PE) that afflicts susceptible persons after rapid ascent to high altitude above 2500 m...
- Genetic determinants of Tibetan high-altitude adaptation
Tatum S Simonson
Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA
Hum Genet 131:527-33. 2012
..e., polycythemia). Recent studies have highlighted several genes subject to natural selection in native high-altitude Tibetans...
- Reproducibility of performance changes to simulated live high/train low altitude
Eileen Y Robertson
Department of Physiology, Australian Institute of Sport, Canberra, Australia
Med Sci Sports Exerc 42:394-401. 2010
Elite athletes often undertake multiple altitude exposures within and between training years in an attempt to improve sea level performance.
- Combining hypoxic methods for peak performance
Gregoire P Millet
ISSUL, Institute of Sport Science, University of Lausanne, Lausanne, Switzerland
Sports Med 40:1-25. 2010
New methods and devices for pursuing performance enhancement through altitude training were developed in Scandinavia and the USA in the early 1990s...
- Physiological adaptation of the cardiovascular system to high altitude
Erasme University Hospital, Brussels, Belgium
Prog Cardiovasc Dis 52:456-66. 2010
b>Altitude exposure is associated with major changes in cardiovascular function...
- The contribution of haemoglobin mass to increases in cycling performance induced by simulated LHTL
Laura A Garvican
Sports Science Sports Medicine, Australian Institute of Sport, PO Box 176, Belconnen, Canberra, ACT, 2616, Australia
Eur J Appl Physiol 111:1089-101. 2011
..However, increases in Hb(mass) appear to influence the aerobic contribution to high-intensity exercise which may be important for subsequent high-intensity efforts...
- Plasma adipokine and hormone changes in mountaineers on ascent to 5300 meters
Jessica D Smith
Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Laval University, Quebec, QC, Canada
Wilderness Environ Med 22:107-14. 2011
..In particular, acylation-stimulating protein (ASP), which influences fat storage in adipose tissue, has not been measured at high altitude.
- Altitude and endurance training
Heikki K Rusko
KIHU Research Institute for Olympic Sports, Jyvaskyla, Finland
J Sports Sci 22:928-44; discussion 945. 2004
The benefits of living and training at altitude (HiHi) for an improved altitude performance of athletes are clear, but controlled studies for an improved sea-level performance are controversial...
- Acclimatization of skeletal muscle mitochondria to high-altitude hypoxia during an ascent of Everest
Denny Z Levett
Centre for Altitude, Space, and Extreme Environment Medicine, University College London UCL Institute of Child Health, University College London, London, UK
FASEB J 26:1431-41. 2012
Ascent to high altitude is associated with a fall in the partial pressure of inspired oxygen (hypobaric hypoxia)...
- Peopling the Tibetan plateau: insights from archaeology
School of Social Sciences, Humanities, and Arts, University of California, Merced, CA 95343, USA
High Alt Med Biol 12:141-7. 2011
- High altitude exposure impairs sleep patterns, mood, and cognitive functions
Valdir de Aquino Lemos
Departamento de Psicobiologia Campus São Paulo, Universidade Federal de Sao Paulo, Sao Paulo, Brasil
Psychophysiology 49:1298-306. 2012
..Ten males, aged 23-30 years, were placed in a normobaric chamber simulating an altitude of 4,500 m...
- Blood volume and hemoglobin mass in endurance athletes from moderate altitude
Dept of Sports Medicine and Sports Physiology, University of Bayreuth, 95440 Bayreuth, Germany
Med Sci Sports Exerc 34:1934-40. 2002
To determine whether total hemoglobin (tHb) mass and total blood volume (BV) are influenced by training, by chronic altitude exposure, and possibly by the combination of both conditions.
- Consensus statement on chronic and subacute high altitude diseases
Cayetano Heredia University IIA, Department of Biological and Physiological Sciences, Oxygen Transport Laboratory, Lima 100, Peru
High Alt Med Biol 6:147-57. 2005
..by the International Society for Mountain Medicine (ISMM) at the VI World Congress on Mountain Medicine and High Altitude Physiology (Xining, China; 2004) and represents the committee's interpretation of the current knowledge with ..
- "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance
B D Levine
Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas 75231, Dallas, Texas 75235, USA
J Appl Physiol (1985) 83:102-12. 1997
The principal objective of this study was to test the hypothesis that acclimatization to moderate altitude (2,500 m) plus training at low altitude (1,250 m), "living high-training low," improves sea-level performance in well-trained ..
- Risk mapping of visceral leishmaniasis: the role of local variation in rainfall and altitude on the presence and incidence of kala-azar in eastern Sudan
Dia Eldin A Elnaiem
Department of Zoology, Faculty of Science, University of Khartoum, Sudan
Am J Trop Med Hyg 68:10-7. 2003
..for environmental variables of 190 villages in Gedaref State, including rainfall, vegetation status, soil type, altitude, distance from river, topography, wetness indexes, and average rainfall estimates...
- Prevalence of COPD in five Colombian cities situated at low, medium, and high altitude (PREPOCOL study)
Asociación Colombiana de Neumología y Cirugía de Tórax, Clinica Reina Sofia, Bogota, Colombia
Chest 133:343-9. 2008
The prevalence of COPD in Colombia is unknown. This study aimed to investigate COPD prevalence in five Colombian cities and measure the association between COPD and altitude.
- Muscle tissue adaptations to hypoxia
Department of Anatomy, University of Bern, Buhlstrasse 26, CH 3000 Bern 9, Switzerland
J Exp Biol 204:3133-9. 2001
..It was hypothesized in early reports that chronic hypoxia, as the main physiological stress during exposure to altitude, per se might positively affect muscle oxidative capacity and capillarity...
- Arterial blood gases and oxygen content in climbers on Mount Everest
Michael P W Grocott
Centre for Altitude, Space, and Extreme Environment Medicine, University College London Institute of Human Health and Performance, London, United Kingdom
N Engl J Med 360:140-9. 2009
..We performed direct field measurements of arterial blood gases in climbers breathing ambient air on Mount Everest...
- Effect of altitude on football performance
B D Levine
Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center at Dallas, Texas 75231, USA
Scand J Med Sci Sports 18:76-84. 2008
b>Altitude will impact football performance through two separate and parallel pathways related to the hypobaric (physical) and hypoxic (physiological) components of terrestrial altitude: (a) the decrease in partial pressure of oxygen ..
- Impact of a century of climate change on small-mammal communities in Yosemite National Park, USA
Museum of Vertebrate Zoology, University of California, Berkeley, CA 94720, USA
Science 322:261-4. 2008
..Elevational replacement among congeners changed because species' responses were idiosyncratic. Though some high-elevation species are threatened, protection of elevation gradients allows other species to respond via migration...
- Air to muscle O2 delivery during exercise at altitude
Jose A L Calbet
Department of Physical Education, University of Las Palmas de Gran Canaria, Spain
High Alt Med Biol 10:123-34. 2009
..During exercise in hypoxia, diffusion limitation explains most of the additional Pao2-Pao2. With altitude, acclimatization exercise (Pao2-Pao2) is reduced, but does not reach the low values observed in high altitude ..
- Austrian Moderate Altitude Study 2000 (AMAS 2000). The effects of moderate altitude (1,700 m) on cardiovascular and metabolic variables in patients with metabolic syndrome
Klinische Abteilung für Allgemeine und Chirurgische Intensivmedizin der Klinik für Anästhesie und Intensivmedizin, 6020 Innsbruck, Austria
Eur J Appl Physiol 88:506-14. 2003
..Baseline investigations were performed at Innsbruck (500 m above sea level). During the 3-week altitude stay the participants simulated a holiday with moderate sports activities...
- Effect of altitude on football performance: analysis of the 2010 FIFA World Cup Data
George P Nassis
Department of Sport Medicine and Biology of Exercise, Faculty of Physical Education and Sport Science, National and Kapodistrian University of Athens, Athens, Greece
J Strength Cond Res 27:703-7. 2013
Laboratory studies show that altitude ascent impairs endurance performance. Limited data exist on football, and information from official matches is very scarce even for other team sports...
- Short-term hematological effects upon completion of a four-week simulated altitude camp
Department of Sports Medicine, University Hospital of Freiburg, Freiburg, Germany
Int J Sports Physiol Perform 7:79-83. 2012
..mass (tHb) is considered to be a main factor for sea-level performance after "live high-train low" (LHTL) altitude training, but little research has focused on the persistence of tHb following cessation of altitude exposure...
- Explorative genome scan to detect candidate loci for adaptation along a gradient of altitude in the common frog (Rana temporaria)
Laboratoire d Ecologie Alpine, CNRS UMR 5553, Universite Joseph Fourier, Grenoble, France
Mol Biol Evol 23:773-83. 2006
..This study investigated the genetic frame of adaptation to a gradient of altitude in the common frog (Rana temporaria) by means of a genome scan based on 392 amplified fragment length ..
- Weight loss at high altitude: pathophysiology and practical implications
Green College and Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK
Eur J Gastroenterol Hepatol 18:5-10. 2006
Climbers at high altitude (>5000 m) lose weight. This impairs performance and safety, but the mechanisms are not entirely due to an imbalance between energy intake and expenditure...
- The effect of acute simulated moderate altitude on power, performance and pacing strategies in well-trained cyclists
Sally A Clark
Department of Physiology, Australian Institute of Sport, Canberra, ACT, Australia
Eur J Appl Physiol 102:45-55. 2007
Athletes regularly compete at 2,000-3,000 m altitude where peak oxygen consumption (VO2peak) declines approximately 10-20%...
- Physiology and pathophysiology with ascent to altitude
Biff F Palmer
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Am J Med Sci 340:69-77. 2010
With increasing altitude, there is a fall in barometric pressure and a progressive fall in the partial pressure of oxygen...
- The altitude-for-latitude disparity in the range retractions of woody species
Alistair S Jump
School of Biological and Environmental Sciences, University of Stirling, Stirling, FK9 4LA, UK
Trends Ecol Evol 24:694-701. 2009
..into a approximately 10-km latitudinal retreat based on the rate at which temperatures decline with increasing altitude and latitude, yet reports of latitudinal range retractions are sparse...
- Mitogenomic analysis of Chinese snub-nosed monkeys: Evidence of positive selection in NADH dehydrogenase genes in high-altitude adaptation
Laboratory for Conservation and Utilization of Bio resource and Key Laboratory for Microbial Resources of the Ministry of Education, Yunnan University, Kunming, 650091, PR, China
Mitochondrion 11:497-503. 2011
..the subfamily Colobinae (or leaf-eating monkeys), these endangered primates are unique in being adapted to a high altitude environment and display a remarkable ability to tolerate low temperatures and hypoxia...
- The high-altitude brain
T F Hornbein
Department of Anesthesiology, University of Washington, Seattle, WA 98195, USA
J Exp Biol 204:3129-32. 2001
..physiological mechanisms that might cause or contribute to both decrements in real-time performance while at altitude and residual deficits for a time after return to low elevations; the effects of hypoxia on brain cells are an ..
- Altitude ammonia-oxidizing bacteria and archaea in soils of Mount Everest
Li Mei Zhang
State Key Laboratory of Urban and Regional Ecology, Research Centre for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing, China
FEMS Microbiol Ecol 70:52-61. 2009
..Archaeal amoA abundance was greater than bacterial amoA abundance in lower altitude soils (<or=5400 m a.s.l.), but this situation was reversed in higher altitude soils (>or=5700 m a.s.l.)...
- Phenotypic plasticity and genetic adaptation to high-altitude hypoxia in vertebrates
Jay F Storz
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588, USA
J Exp Biol 213:4125-36. 2010
High-altitude environments provide ideal testing grounds for investigations of mechanism and process in physiological adaptation...
- Altitude-dependent Bartonella quintana genotype C in head lice, Ethiopia
Universite de la Mediterranee, Marseille, France
Emerg Infect Dis 17:2357-9. 2011
..B. quintana was found in 19 (7%) genotype C head lice and in 76 (18%) genotype A body lice. B. quintana in head lice was positively linked to altitude (p = 0.014).
- Effect of topography on the risk of malaria infection in the Usambara Mountains, Tanzania
M J Balls
School of Biological and Biomedical Sciences, Science Laboratories, South Road, Durham DH1 3LE, UK
Trans R Soc Trop Med Hyg 98:400-8. 2004
..Univariate analysis showed that the risk of splenomegaly declined with increasing altitude and with decreasing potential for water to accumulate...
- Topography and malaria transmission heterogeneity in western Kenya highlands: prospects for focal vector control
Andrew K Githeko
Climate and Human Health Research Unit, Centre for Vector Biology and Control Research, Kenya Medical Research Institute, Kisumu, Kenya
Malar J 5:107. 2006
..The aim of this study was to determine the effects of topography on malaria spatial vector distribution and parasite prevalence...
- Introduced Plasmodium vivax malaria in a Bolivian community at an elevation of 2,300 meters
Harvard Medical School, Boston, Massachusetts, USA
Am J Trop Med Hyg 70:15-9. 2004
..This outbreak demonstrates the vulnerability of highland populations with poor access to health care to introduced malaria...
- Chest ultrasonography for the diagnosis and monitoring of high-altitude pulmonary edema
Peter J Fagenholz
MFA, Department of Emergency Medicine, Clinics 115, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02140, USA
Chest 131:1013-8. 2007
..This is the first report describing its use for the diagnosis and monitoring of high-altitude pulmonary edema (HAPE), the leading cause of death from altitude illness.
- Fasciola hepatica and lymnaeid snails occurring at very high altitude in South America
Departamento de Parasitologia, Facultad de Farmacia, Universidad de Valencia, Burjassot Valencia, Spain
Parasitology 123:S115-27. 2001
..singular epidemiological characteristics of human fascioliasis is the link of the hyperendemic areas to very high altitude regions, at least in South America...
- Child health and living at high altitude
University of Colorado School of Medicine, Department of Pediatrics Neonatology, The Children s Hospital, Denver, Colorado 80218 1088, USA
Arch Dis Child 94:806-11. 2009
The health of children born and living at high altitude is shaped not only by the low-oxygen environment, but also by population ancestry and sociocultural determinants...
- Changing patterns of clinical malaria since 1965 among a tea estate population located in the Kenyan highlands
G D Shanks
US Army Medical Research Unit Kenya
Trans R Soc Trop Med Hyg 94:253-5. 2000
..The coincident arrival of chloroquine resistance during the late 1980s in the subregion suggests that drug resistance is a key factor in the current pattern and burden of malaria among this highland population...
- High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein
Ludwig Maximilians University, Munich, Germany
Cytokine 12:246-52. 2000
Hypoxic pulmonary vasoconstriction is associated with but may not be sufficient for the development of high-altitude pulmonary oedema (HAPO). Hypoxia is known to induce an inflammatory response in immune cells and endothelial cells...
- Terrestrial insects along elevation gradients: species and community responses to altitude
Ian D Hodkinson
School of Biological and Earth Sciences, Liverpool John Moores University, Byrom St, Liverpool L3 3AF, UK
Biol Rev Camb Philos Soc 80:489-513. 2005
..awareness that such responses may serve as analogues for climate warming effects occurring at a particular fixed altitude or latitude over time...
- Continuous positive airway pressure increases haemoglobin O2 saturation after acute but not prolonged altitude exposure
Centro Cardiologico Monzino, IRCCS, Istituto di Cardiologia, Universita di Milano, Via Parea 4, 20138 Milan, Italy
Eur Heart J 31:457-63. 2010
It is unknown whether subclinical high-altitude pulmonary oedema reduces spontaneously after prolonged altitude exposure...
- Transpulmonary plasma ET-1 and nitrite differences in high altitude pulmonary hypertension
Marc M Berger
Department of Anesthesiology, University of Heidelberg, Germany
High Alt Med Biol 10:17-24. 2009
..Swenson. Transpulmonary plasma ET-1 and nitrite differences in high altitude pulmonary hypertension. High Alt. Med. Biol. 10:17-24, 2009...
- Clinical features of headache at altitude: a prospective study
King s Regional Neuroscience Center, London, UK
Neurology 60:1167-71. 2003
Headache is the most common nervous system complication at altitude; however, there have been few attempts to characterize clinical features of high-altitude headaches (HAH).
- Structural modifications of the brain in acclimatization to high-altitude
Laboratory for Higher Brain Function, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
PLoS ONE 5:e11449. 2010
Adaptive changes in respiratory and cardiovascular responses at high altitude (HA) have been well clarified. However, the central mechanisms underlying HA acclimatization remain unclear...
- Hypobaric hypoxia causes body weight reduction in obese subjects
Florian J Lippl
Division of Gastroenterology, Department of Internal Medicine, University Hospital of Ludwig Maximilians University, Munich, Germany
Obesity (Silver Spring) 18:675-81. 2010
..The aim of our study was to examine the effect of hypobaric hypoxia on body weight at high altitude in obese subjects. We investigated 20 male obese subjects (age 55.7 +/- 4.1 years, BMI 33.7 +/- 1.0 kg/m(2))...
- Visual control of altitude in flying Drosophila
Andrew D Straw
Bioengineering, California Institute of Technology, Pasadena, CA 91125, USA
Curr Biol 20:1550-6. 2010
..of the visual reflexes that regulate horizontal course, the sensory-motor mechanisms that animals use to control altitude are poorly understood...
- Endocrine and metabolic responses to extreme altitude and physical exercise in climbers
Division of Endocrinology and Metabolism, Department of Internal Medicine, Molinette Hospital, University of Turin, Corso Dogliotti 14, 10126 Turin, Italy
Eur J Endocrinol 157:733-40. 2007
Chronic hypoxia induces complex metabolic and endocrine adaptations. High-altitude (HA) exposure is a physiological model of hypoxia.
- Reduced autonomic activity during stepwise exposure to high altitude
Department of Cardiology, , Oslo, Norway
Acta Physiol Scand 173:409-17. 2001
..a recent field study we found reduced plasma catecholamines during the first days after a stepwise ascent to high altitude. In the present study 14 subjects were exposed to a simulated ascent in a hypobaric chamber to test the ..
- Mobile carbohydrates in Himalayan treeline trees I. Evidence for carbon gain limitation but not for growth limitation
Mai He Li
Swiss Federal Institute for Forest, Snow and Landscape Research WSL, Zuercherstrasse 111, Birmensdorf, Switzerland
Tree Physiol 28:1287-96. 2008
..For comparison, we investigated a low-altitude species (Tsuga yunnanensis (Franch.) Pritz...
- Timing and duration of European larch growing season along altitudinal gradients in the Swiss Alps
Institute of Geography, Climatology and Meteorology Research Group, University of Bern, Hallerstrasse 12, CH 3012 Bern, Switzerland
Tree Physiol 30:225-33. 2010
..changed by 3-4 days per 100 m elevation; the ending of the growing season, however, appeared minimally related to altitude. If associated with the monitored altitudinal lapse rate of -0...
- Breathing patterns and cardiovascular autonomic modulation during hypoxia induced by simulated altitude
Department of Internal Medicine, University of Pavia and IRCCS S. Matteo, Italy
J Hypertens 19:947-58. 2001
..the influence of different breathing patterns on autonomic cardiovascular modulation during acute exposure to altitude-induced hypoxia...
- Human behaviour and development under high-altitude conditions
Department of Personality, Assessment and Treatment, Universidad de Granada, Spain
Dev Sci 9:400-10. 2006
Although we are far from a universally accepted pattern of impaired function at altitude, there is evidence indicating motor, perceptual, memory and behavioural deficits in adults...
- The carbon charging of pines at the climatic treeline: a global comparison
Institute of Botany, University of Basel, Schönbeinstrasse 6, 4056 Basel, Switzerland
Oecologia 135:10-21. 2003
..It seems rather that low temperatures directly affect sink activity at the treeline, with surplus carbon stored in osmotically inactive compounds...
- Population structure of Columbia spotted frogs (Rana luteiventris) is strongly affected by the landscape
W Chris Funk
Division of Biological Sciences, University of Montana, Missoula, Montana 59812, USA
Mol Ecol 14:483-96. 2005
..Our results show that landscape features have a profound effect on patterns of genetic variation in Columbia spotted frogs...
- Intraocular pressure during a very high altitude climb
Martina M Bosch
Department of Ophthalmology, University Hospital, Zurich, Switzerland
Invest Ophthalmol Vis Sci 51:1609-13. 2010
..Reports on intraocular pressure (IOP) changes at high altitudes have provided inconsistent and even conflicting..
- Low larval vector survival explains unstable malaria in the western Kenya highlands
C J M Koenraadt
Laboratory of Entomology, Department of Plant Sciences, Wageningen University, The Netherlands
Trop Med Int Health 11:1195-205. 2006
..and malaria vector survival in a highland area in western Kenya, ranging from approximately 1,550-1,650 m altitude. Although only five adult malaria vectors were collected during 180 light traps and 180 resting collections over ..
- New insights into ocular blood flow at very high altitudes
Martina M Bosch
Department of Opthamology, University Hospital, Zurich, Switzerland
J Appl Physiol (1985) 106:454-60. 2009
..flow resulting from altered autoregulation constitutes a risk factor for acute mountain sickness (AMS) and high-altitude cerebral edema (HACE) by leading to capillary overperfusion and vasogenic cerebral edema...
- New highland distribution records of multiple Anopheles species in the Ecuadorian Andes
Lauren L Pinault
Department of Biological Sciences, Brock University, F211 Mackenzie Chown Complex, 500 Glenridge Avenue, St, Catharines, Canada, L2S 3A1
Malar J 10:236. 2011
..This study attempts to expand the current knowledge of the distribution of common Anopheles species in Ecuador, with particular attention to highland regions (> 500 m) of the Andes...
- On the origin of Tibetans and their genetic basis in adapting high-altitude environments
National Research Institute for Family Planning, Beijing, People s Republic of China
PLoS ONE 6:e17002. 2011
..Most of these genes were highly correlated with population-specific and beneficial phenotypes, such as high infant survival rate and the absence of chronic mountain sickness...
- Environmental, socio-demographic and behavioural determinants of malaria risk in the western Kenyan highlands: a case-control study
Kacey C Ernst
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA
Trop Med Int Health 14:1258-65. 2009
..To identify risk factors for uncomplicated malaria in highland areas of East Africa at higher risk of malaria epidemics, in order to design appropriate interventions...
- Scale effects and human impact on the elevational species richness gradients
Department of Biodiversity and Evolutionary Biology, National Museum of Natural Sciences, CSIC, c Jose Gutierrez Abascal, 2, 28006 Madrid, Spain
Nature 453:216-9. 2008