inhalation

Summary

Summary: The act of BREATHING in.

Top Publications

  1. doi Adverse cardiovascular, cerebrovascular, and peripheral vascular effects of marijuana inhalation: what cardiologists need to know
    Grace Thomas
    Marshfield Clinic Research Foundation, Marshfield, Wisconsin
    Am J Cardiol 113:187-90. 2014
  2. doi Robust odor coding via inhalation-coupled transient activity in the mammalian olfactory bulb
    Kevin M Cury
    Department of Molecular and Cellular Biology, Harvard University, Center for Brain Science, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Neuron 68:570-85. 2010
  3. ncbi Influence of lung volume, glossopharyngeal inhalation and P(ET) O2 and P(ET) CO2 on apnea performance in trained breath-hold divers
    Kristian Overgaard
    Department of Sport Science, University of Aarhus, Katrinebjergvej 89C, 8200, Aarhus N, Denmark
    Eur J Appl Physiol 97:158-64. 2006
  4. doi Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury
    Kentaro Hayashida
    Division of Cardiology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 373:30-5. 2008
  5. ncbi Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis
    Nicholas L Mills
    Centre for Cardiovascular Science, Edinburgh University, Edinburgh, Scotland
    Circulation 112:3930-6. 2005
  6. ncbi Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation
    Melanie F Struve
    CIIT Centers for Health Research, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Am J Ind Med 50:772-8. 2007
  7. pmc An inhalation model of airway allergic response to inhalation of environmental Aspergillus fumigatus conidia in sensitized BALB/c mice
    Scott A Hoselton
    Department of Veterinary and Microbiological Sciences, North Dakota State University, Fargo, North Dakota, USA
    Med Mycol 48:1056-65. 2010
  8. ncbi Inspiratory muscle training in patients with chronic obstructive pulmonary disease: structural adaptation and physiologic outcomes
    Alba Ramirez-Sarmiento
    Servei de Pneumologia, Hospital del Mar Grup de Recerca de Pneumologia, Unitat de Recerca Respiratoria i Ambiental, Barcelona, Spain
    Am J Respir Crit Care Med 166:1491-7. 2002
  9. pmc A comparison between intratracheal and inhalation delivery of Aspergillus fumigatus conidia in the development of fungal allergic asthma in C57BL/6 mice
    Amali E Samarasinghe
    Department of Veterinary and Microbiological Sciences, North Dakota State University, P O Box 6050, Dept 7690, Fargo, ND 58108, USA
    Fungal Biol 115:21-9. 2011
  10. ncbi Corticospinal control of respiratory muscles in chronic obstructive pulmonary disease
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Royal Brompton Hospital, London SW3 6NP, UK
    Respir Physiol Neurobiol 141:1-12. 2004

Detail Information

Publications312 found, 100 shown here

  1. doi Adverse cardiovascular, cerebrovascular, and peripheral vascular effects of marijuana inhalation: what cardiologists need to know
    Grace Thomas
    Marshfield Clinic Research Foundation, Marshfield, Wisconsin
    Am J Cardiol 113:187-90. 2014
    ..the investigators focus on the known cardiovascular, cerebrovascular, and peripheral effects of marijuana inhalation. Temporal associations between marijuana use and serious adverse events, including myocardial infarction, sudden ..
  2. doi Robust odor coding via inhalation-coupled transient activity in the mammalian olfactory bulb
    Kevin M Cury
    Department of Molecular and Cellular Biology, Harvard University, Center for Brain Science, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Neuron 68:570-85. 2010
    ..During rapid sniffing, odor inhalation triggered rapid and reliable cell- and odor-specific temporal spike patterns...
  3. ncbi Influence of lung volume, glossopharyngeal inhalation and P(ET) O2 and P(ET) CO2 on apnea performance in trained breath-hold divers
    Kristian Overgaard
    Department of Sport Science, University of Aarhus, Katrinebjergvej 89C, 8200, Aarhus N, Denmark
    Eur J Appl Physiol 97:158-64. 2006
    Breath-hold divers train and compete in maximal apnea performance. Glossopharyngeal inhalation (GI) is commonly used to increase lung volume above vital capacity (VC) prior to apnea...
  4. doi Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury
    Kentaro Hayashida
    Division of Cardiology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 373:30-5. 2008
    b>Inhalation of hydrogen (H(2)) gas has been demonstrated to limit the infarct volume of brain and liver by reducing ischemia-reperfusion injury in rodents...
  5. ncbi Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis
    Nicholas L Mills
    Centre for Cardiovascular Science, Edinburgh University, Edinburgh, Scotland
    Circulation 112:3930-6. 2005
    ..The study aim was to investigate the effects of diesel exhaust inhalation on vascular and endothelial function in humans.
  6. ncbi Basal ganglia neurotransmitter concentrations in rhesus monkeys following subchronic manganese sulfate inhalation
    Melanie F Struve
    CIIT Centers for Health Research, The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Am J Ind Med 50:772-8. 2007
    ..Manganese neurotoxicity in humans is recognized as a form of parkinsonism with lesions occurring predominantly within the globus pallidus, subthalamic nucleus, putamen, and caudate nucleus...
  7. pmc An inhalation model of airway allergic response to inhalation of environmental Aspergillus fumigatus conidia in sensitized BALB/c mice
    Scott A Hoselton
    Department of Veterinary and Microbiological Sciences, North Dakota State University, Fargo, North Dakota, USA
    Med Mycol 48:1056-65. 2010
    ..To create conditions simulating environmental fungal allergen exposure in a human, nose-only inhalation delivery of Aspergillus fumigatus conidia was employed in mice previously sensitized to Aspergillus antigen ..
  8. ncbi Inspiratory muscle training in patients with chronic obstructive pulmonary disease: structural adaptation and physiologic outcomes
    Alba Ramirez-Sarmiento
    Servei de Pneumologia, Hospital del Mar Grup de Recerca de Pneumologia, Unitat de Recerca Respiratoria i Ambiental, Barcelona, Spain
    Am J Respir Crit Care Med 166:1491-7. 2002
    ..No changes were observed in the control muscle. The study demonstrates that inspiratory training induces a specific functional improvement of the inspiratory muscles and adaptive changes in the structure of external intercostal muscles...
  9. pmc A comparison between intratracheal and inhalation delivery of Aspergillus fumigatus conidia in the development of fungal allergic asthma in C57BL/6 mice
    Amali E Samarasinghe
    Department of Veterinary and Microbiological Sciences, North Dakota State University, P O Box 6050, Dept 7690, Fargo, ND 58108, USA
    Fungal Biol 115:21-9. 2011
    ..Here, we compared the IT model with a newly developed inhalation (IH) challenge model...
  10. ncbi Corticospinal control of respiratory muscles in chronic obstructive pulmonary disease
    Nicholas S Hopkinson
    Respiratory Muscle Laboratory, Royal Brompton Hospital, London SW3 6NP, UK
    Respir Physiol Neurobiol 141:1-12. 2004
    ..These results suggest that there is a ceiling effect in motor control output to the respiratory muscles of patients with COPD...
  11. ncbi Utility of clinical swallowing examination measures for detecting aspiration post-stroke
    G H McCullough
    University of Arkansas for Medical Sciences Medical Center, Little Rock 72205, USA
    J Speech Lang Hear Res 48:1280-93. 2005
    ..At present, there are no data to suggest that CSEs can be used to quantify aspiration or make adequate recommendations regarding patient care...
  12. doi Bioaccessibility studies of ferro-chromium alloy particles for a simulated inhalation scenario: a comparative study with the pure metals and stainless steel
    Klara Midander
    Division of Surface and Corrosion Science, School of Chemical Science and Engineering, Royal Institute of Technology KTH, Drottning Kristinas vag 51, SE 100 44 Stockholm, Sweden
    Integr Environ Assess Manag 6:441-55. 2010
    ..and stainless steel exposed at in vitro conditions in synthetic biological media of relevance for particle inhalation and ingestion...
  13. ncbi Modeling airway resistance dynamics after tidal and deep inspirations
    C William Thorpe
    Woolcock Institute of Medical Research, Camperdown, NSW 2050, Australia
    J Appl Physiol (1985) 97:1643-53. 2004
    ..66. This suggests that the same time-dependent factors determine renarrowing after both large and small breaths...
  14. ncbi Responses of the diaphragm to transcranial magnetic stimulation during wake and sleep in humans
    Selma Mehiri
    Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Paris, France
    Respir Physiol Neurobiol 154:406-18. 2006
    ....
  15. ncbi Inhalation of inorganic particles as a risk factor for idiopathic pulmonary fibrosis--elemental microanalysis of pulmonary lymph nodes obtained at autopsy cases
    Hideya Kitamura
    The Division of Respiratory Medicine, Department of Internal Medicine, The Jikei University School of Medicine, Japan
    Pathol Res Pract 203:575-85. 2007
    ..This study shows that inorganic particles, such as Si and Al, have higher concentrations in the hilar lymph nodes in IPF/UIP, and may play a role in one of the risk factors in the pathogenesis of IPF/UIP...
  16. doi Foreign body aspiration in children: the value of diagnostic criteria
    Gursu Kiyan
    Marmara University School of Medicine, Department of Pediatric Surgery, Tophanelioglu cad 13 15, Altunizade Uskudar, 34662 Istanbul, Turkey
    Int J Pediatr Otorhinolaryngol 73:963-7. 2009
    ..Finally, we evaluated the validity of our bronchoscopy indications in these patients...
  17. ncbi The sleep-enhancing effect of valerian inhalation and sleep-shortening effect of lemon inhalation
    Teruhisa Komori
    Department of Psychiatry, Division of Neuroscience, Institute of Medical Science, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Chem Senses 31:731-7. 2006
    We examined the effects of odorant inhalation on the sleep-wake states in rats. Odorants used in the experiment were clove, jasmine, lavender, lemon, peppermint, pine, rose, sandalwood, valerian, and ylang-ylang...
  18. doi Inhalation of menthol reduces capsaicin cough sensitivity and influences inspiratory flows in chronic cough
    Eva Millqvist
    Department of Internal Medicine Respiratory Medicine and Allergology, the Sahlgrenska Academy at University of Gothenburg, Sweden
    Respir Med 107:433-8. 2013
    ..This study aimed to assess whether pre-inhalation of dissolved, nebulised menthol could increase capsaicin cough thresholds and influence spirometric values.
  19. ncbi Comparison of specific expiratory, inspiratory, and combined muscle training programs in COPD
    Paltiel Weiner
    Department of Medicine A, Hillel Yaffe Medical Center, Hadera, Israel
    Chest 124:1357-64. 2003
    ..On the other hand, there is a paucity of data related to expiratory muscle performance and training in COPD...
  20. ncbi Assessing penetration and aspiration: how do videofluoroscopy and fiberoptic endoscopic evaluation of swallowing compare?
    Annette M Kelly
    Head and Neck Tumour Centre, University College Hospital, London, UK
    Laryngoscope 117:1723-7. 2007
    ..We aimed to investigate whether the type of dysphagia examination (fiberoptic endoscopic evaluation of swallowing [FEES] or videofluoroscopy) influences the scoring of penetration and aspiration...
  21. doi Generation of eupnea and sighs by a spatiochemically organized inspiratory network
    Araya Ruangkittisakul
    Department of Physiology and Perinatal Research Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Neurosci 28:2447-58. 2008
    ....
  22. ncbi Sensory and affective pain discrimination after inhalation of essential oils
    Jeffrey J Gedney
    Division of Public Health Services and Research, University of Florida College of Dentistry, Gainesville, FL, USA
    Psychosom Med 66:599-606. 2004
    ..The purpose of this investigation was to examine the effects of olfactory absorption of two commonly used therapeutic essential oils on sensory and affective responses to experimentally induced pain...
  23. ncbi Medical emergencies in a dental office: inhalation and ingestion of orthodontic objects
    Leon Bilder
    Department of Community Dentistry, Hebrew University Hadassah School of Dental Medicine, Jerusalem Israel
    J Am Dent Assoc 142:45-52. 2011
    The authors reviewed the literature regarding inhalation and ingestion of orthodontic appliances and suggest ways to manage and prevent these events.
  24. ncbi The effects of prolonged rose odor inhalation in two animal models of anxiety
    B F Bradley
    Department of Psychology, University of Central Lancashire, Preston, Lancashire, PR1 2HE, UK
    Physiol Behav 92:931-8. 2007
    ..01, chronic U=178, p<0.05). This anxiolytic profile strengthened after chronic exposure to rose odor, transitions between the compartments (U=167, p<0.01) and percentage of time moving around the arena (U=154, p<0.001) increased...
  25. pmc Adolescent toluene inhalation in rats affects white matter maturation with the potential for recovery following abstinence
    Jhodie Rubina Duncan
    Division of Behavioural Neuroscience, Florey Neuroscience Institutes, University of Melbourne, Melbourne, Victoria, Australia
    PLoS ONE 7:e44790. 2012
    ..Consequently, exposure to inhalants that contain toluene during adolescence and early adulthood appear to differentially affect white matter maturation and behavioural outcomes, although recovery can occur following abstinence...
  26. doi Concept to estimate regional inhalation dose of industrially synthesized nanoparticles
    Antti J Koivisto
    Nanosafety Research Center, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FI 00250 Helsinki, Finland
    ACS Nano 6:1195-203. 2012
    ..This study presents one method for estimating workers' calculated regional inhalation dose of deposited particles from size-fractionated concentrations...
  27. doi Estimation of daily inhalation rate in preschool children using a tri-axial accelerometer: a pilot study
    Junko Kawahara
    Research Center for Environmental Risks, National Institute for Environmental Studies, Tsukuba, Japan
    Sci Total Environ 409:3073-7. 2011
    ..The daily inhalation rate and time spent in sedentary, light, or moderate to vigorous levels of physical activity (MVPA) were ..
  28. pmc Areas of the brain concerned with ventilatory load compensation in awake man
    Gennadi Isaev
    Pavlov Institute of Physiology, St Petersburg, Russia
    J Physiol 539:935-45. 2002
    ..This results in a prolongation of T(I), the maintenance of V(T) and a reduction in the degree of discomfort, presumably because of the reduction of mean negative pressure in the airways...
  29. pmc Particle size distribution and inhalation dose of shower water under selected operating conditions
    Yue Zhou
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
    Inhal Toxicol 19:333-42. 2007
    ..Alveolar deposition was 6-10% and 0.9% assuming oral and nasal breathing, respectively. The consequences deposition of shower water droplets will depend on the nature and extent of any pollutants in the source water...
  30. doi [Fatal poisoning by accidental inhalation of aluminium phosphide]
    J L Perez Navero
    Unidad de Cuidados Intensivos Pediatricos, Servicio de Pediatria, Críticos y Urgencias, Hospital Universitario Reina Sofia, Cordoba, Espana
    An Pediatr (Barc) 71:427-31. 2009
    The cases of two 6 and 9-year-old sisters with lethal poisoning by inhalation of aluminium phosphide, after its inadequate use in a rural environment, are described...
  31. ncbi Effect of facial cooling and cold air inhalation on sympathetic nerve activity in men
    Silke Heindl
    Department of Internal Medicine I, University of Luebeck, Ratzeburger Allee 160, 23538, Germany
    Respir Physiol Neurobiol 142:69-80. 2004
    ..to the forehead and hand, to the oral and nasal cavities via ice cubes and to the bronchial system via inhalation of cold air (-25 degrees C)...
  32. doi Low-frequency ultrasound permeates the human thorax and lung: a novel approach to non-invasive monitoring
    D Rueter
    Institute of Pharmacology and Toxicology, RWTH Aachen
    Ultraschall Med 31:53-62. 2010
    ..However, human thoraxes and lungs in situ were never rigorously probed with ultrasound at frequencies below 1 MHz. In addition, ultrasound is commonly applied as echo imaging rather than sound transmission...
  33. doi Acute respiratory distress syndrome from chlorine inhalation during a swimming pool accident: a case report and review of the literature
    Rajesh V Babu
    Department of Internal Medicine, Division of Allergy, Pulmonary, Immunology, Critical Care, and Sleep, University of Texas Medical Branch, Galveston, Texas, USA
    J Intensive Care Med 23:275-80. 2008
    Chlorine inhalation can result in significant morbidity and mortality. The most common clinical ramification is mucosal irritation. Rarely, depending upon the degree of exposure, patients can develop acute respiratory distress syndrome...
  34. ncbi Estimation of the bronchodilatory effect of deep inhalation after a free run in children
    C Schweitzer
    Service d Explorations Fonctionnelles Pédiatriques, Hôpital d Enfants, Centre Hospitalier Universitaire de Nancy, France
    Eur Respir J 28:89-95. 2006
    The bronchomotor effects of a deep inhalation (DI) may provide relevant information about the mechanisms of exercise-induced airway obstruction in children and may be assessed by respiratory conductance (Grs) measured using the forced ..
  35. doi Effect of deep inspiration avoidance on ventilation heterogeneity and airway responsiveness in healthy adults
    David G Chapman
    Woolcock Institute of Medical Research, Sydney, New South Wales, Australia
    J Appl Physiol (1985) 110:1400-5. 2011
    ..This was followed by another 20-min period of DI avoidance before the inhalation of a single methacholine dose...
  36. ncbi Inspiratory muscle unloading by neurally adjusted ventilatory assist during maximal inspiratory efforts in healthy subjects
    Christer Sinderby
    Department of Critical Care, St Michael s Hospital, University of Toronto, 30 Bond Street, Queen 4 072, Toronto, ON, Canada
    Chest 131:711-7. 2007
    ..The aims of this study were to evaluate whether NAVA could efficiently unload the respiratory muscles during maximal inspiratory efforts, and if a high level of NAVA would suppress EAdi without increasing lung-distending pressures...
  37. ncbi [Fungal infection induced by Cryptococcus neoformans aerosol inhalation in immunosuppressed Balb/c mice]
    Meiqin Fu
    Department of Medical Microbiology, Southern Medical University, Guangzhou, China
    Nan Fang Yi Ke Da Xue Xue Bao 32:169-72. 2012
    To explore the feasibility of inducing fungal infection by Cryptococcus neoformans aerosol inhalation in immunosuppressed Balb/c mice.
  38. doi Germline mutation rates in mice following in utero exposure to diesel exhaust particles by maternal inhalation
    Caitlin Ritz
    Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario K1A 0K9, Canada
    Mutat Res 712:55-8. 2011
    ..e., sperm or egg) of mice exposed in utero to diesel exhaust particles (DEPs) via maternal inhalation compared to unexposed controls was investigated in this study...
  39. doi Elimination of visually evoked BOLD responses during carbogen inhalation: implications for calibrated MRI
    C J Gauthier
    Physiology Biomedical Engineering, Universite de Montreal, Montreal, Quebec, Canada
    Neuroimage 54:1001-11. 2011
    ..a separate cohort indicated a largely preserved perfusion response (89±34%, n=5) to the visual stimulus during inhalation of carbogen-10...
  40. doi NAVA enhances tidal volume and diaphragmatic electro-myographic activity matching: a Range90 analysis of supply and demand
    Katherine T Moorhead
    Cardiovascular Research Center, University of Liege, Liege, Belgium
    J Clin Monit Comput 27:61-70. 2013
    ..NAVA provided better matching of Vt to ʃEadi for 21 of 22 patients, and provided greater variability Vt. These results were achieved regardless of differences in ventilatory demand (Eadi) between patients and modes...
  41. doi Inhalation of expiratory droplets in aircraft cabins
    J K Gupta
    National Air Transportation Center of Excellence for Research in the Intermodal Transport Environment RITE, School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA
    Indoor Air 21:341-50. 2011
    ..The method, if coupled with information on the viability and the amount of infectious agent in the droplet, can aid in evaluating the infection risk...
  42. pmc Talcum induced pneumoconiosis following inhalation of adulterated marijuana, a case report
    Andreas Hans Scheel
    Institute of Pathology, Klinikum Bremen Mitte, Bremen, Germany
    Diagn Pathol 7:26. 2012
    Talcosis, a granulomatous inflammation of the lungs caused by inhalation of talcum dust, is a rare form of pneumoconiosis...
  43. pmc Transient oscillatory force-length behavior of activated airway smooth muscle
    J H T Bates
    Vermont Lung Center, University of Vermont College of Medicine, Burlington, 05405 0075, USA
    Am J Physiol Lung Cell Mol Physiol 297:L362-72. 2009
    ..We speculate that this force decrement reflects some mechanism unrelated to the cycling of crossbridges, and which may be involved in the reversal of bronchoconstriction induced by a deep inflation of the lungs in vivo...
  44. ncbi Turban pin aspiration; a potential risk for young Islamic girls
    M Kaptanoglu
    Department of Thoracic and Cardiovascular Surgery, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey
    Int J Pediatr Otorhinolaryngol 48:131-5. 1999
    ..Repeated bronchoscopy rate was 8% (n = 5) and we had no mortality. This recently recognized aspiration hazard can be minimized by using adhesive bands or snap fasteners, instead of pins, when wearing a turban...
  45. ncbi [Respiratory consequences of inhalation of adulterated cannabis]
    J Delourme
    Service de Pneumologie, Hôpital Victor Provo, Roubaix, France
    Rev Mal Respir 26:552-6. 2009
    ..The first case is a 33 year-old patient admitted for an acute inhalation pneumonitis secondary to smoking cannabis adulterated with grit sand...
  46. ncbi The effects of thinner inhalation on superoxide dismutase activities, malondialdehyde and glutathione levels in rat lungs
    Ahmet Ilgazli
    Department of Chest Disease, Faculty of Medicine, Kocaeli University, Derince 41900, Kocaeli, Turkey
    Clin Chim Acta 343:141-4. 2004
    ..Recent years' usage of thinner by the young generation as a drug constitutes a serious problem in the society. Due to common usage in the industrial sector, most people are affected from the manufacturing process to the consuming phase...
  47. doi Hydrogen inhalation reduced epithelial apoptosis in ventilator-induced lung injury via a mechanism involving nuclear factor-kappa B activation
    Chien Sheng Huang
    Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, United States
    Biochem Biophys Res Commun 408:253-8. 2011
    We recently demonstrated the inhalation of hydrogen gas, a novel medical therapeutic gas, ameliorates ventilator-induced lung injury (VILI); however, the molecular mechanisms by which hydrogen ameliorates VILI remain unclear...
  48. doi Knowledge, attitude, and practice regarding cricoid pressure of ED personnel at a large U.S. teaching hospital
    Olubukola O Nafiu
    Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109 0048, USA
    J Emerg Nurs 35:11-5. 2009
    ..There has been no previous attempt to assess the adequacy of knowledge of ED personnel in the application of CP. The objective of this study was to assess the theoretic knowledge of ED personnel about CP...
  49. ncbi Matrix metalloproteinase induction in fibrosis and fibrotic nodule formation due to silica inhalation
    James F Scabilloni
    National Institute for Occupational Safety and Health, Pathology and Physiology Research Branch, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 288:L709-17. 2005
    ..Rats were exposed to filtered air or 15 mg/m(3) silica by inhalation for 5 days/wk, 6 h/day...
  50. ncbi Tracking variations in airway caliber by using total respiratory vs. airway resistance in healthy and asthmatic subjects
    L D Black
    Department of Biomedical Engineering, 44 Cummington St, Boston, MA 02215, USA
    J Appl Physiol 95:511-8. 2003
    ..We conclude that the volume dependence of Rcw can bias the presumed net change in airway caliber during tidal breathing and a DI but would not distort assessment of maximum airway dilation...
  51. doi Suspected foreign body inhalation in children: what are the indications for bronchoscopy?
    Shlomo Cohen
    Institute of Pulmonology, Hadassah Ein Kerem, Hadassah Hebrew University Medical Centers, Jerusalem, Israel
    J Pediatr 155:276-80. 2009
    To define the criteria for bronchoscopy in children with suspected foreign body (FB) inhalation.
  52. ncbi Brugada syndrome unmasked by accidental inhalation of gasoline vapors
    Darko Kranjcec
    Department of Cardiology, University Hospital Dubrava, Zagreb, Croatia
    Pacing Clin Electrophysiol 30:1294-8. 2007
    ..of a 46-year-old patient, with no previous medical history, who had ventricular fibrillation after accidental inhalation of gasoline vapors...
  53. doi Rigid bronchoscopy for inhaled pen caps in children
    Sun Jiaqiang
    Department of Otolaryngology, Beijing Tongren Hospital, Key Laboratory of Otolaryngology Head and Neck Surgery, Capital Medical University, Ministry of Education, Beijing 100730, China
    J Pediatr Surg 44:1708-11. 2009
    The aim of this study was to present the clinical findings and treatment of pen cap inhalation with emphasis on the importance of managing aspirated foreign bodies by rigid bronchoscopy.
  54. ncbi The bronchodilatory effect of deep inspiration diminishes with aging
    Nicola Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, Universita di Palermo, Via Trabucco 180, Palermo 90146, Italy
    Respir Med 98:838-43. 2004
    ..0001) and age (P=0.02) entered the model. Our data raise the hypothesis that aging is associated with reduction in DI-induced bronchodilation...
  55. ncbi Using doubly-labeled water measurements of human energy expenditure to estimate inhalation rates
    Marc Stifelman
    U S Environmental Protection Agency, Region 10, Office of Environmental Assessment, Risk Evaluation Unit, 1200 Sixth Avenue, Mail Stop OEA 095, Seattle, WA 98101, USA
    Sci Total Environ 373:585-90. 2007
    ..b>Inhalation rate estimates can benefit from improved energy expenditure estimates using equations developed by Layton...
  56. ncbi Two new radiological findings to improve the diagnosis of bronchial foreign-body aspiration in children
    Guido Girardi
    Pediatric Pulmonary Section, Department of Pediatrics, Exequiel Gonzales Cortes Children s Hospital, University of Chile, Santiago, Chile
    Pediatr Pulmonol 38:261-4. 2004
    ....
  57. ncbi The lack of the bronchoprotective and not the bronchodilatory ability of deep inspiration is associated with airway hyperresponsiveness
    N Scichilone
    Division of Clinical Immunology, Department of Medicine, Johns Hopkins University, School of Medicine, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 163:413-9. 2001
    ..The dissociation between bronchoprotection and bronchodilation suggests that the two effects involve different mechanisms...
  58. ncbi Temporal dynamics and latency patterns of receptor neuron input to the olfactory bulb
    Hartwig Spors
    WIN Group of Olfactory Dynamics, Max Planck Institut fur medizinische Forschung, D 69120 Heidelberg, Germany
    J Neurosci 26:1247-59. 2006
    ..These dynamics may contribute to the representation of odorant information and affect information processing in the central olfactory system of rodents...
  59. doi Nasal airflow rate affects the sensitivity and pattern of glomerular odorant responses in the mouse olfactory bulb
    Yuki Oka
    Department of Integrated Biosciences, The University of Tokyo, Chiba 277 8562, Japan
    J Neurosci 29:12070-8. 2009
    ..Our results provide important information on in vivo odorant recognition and suggest that odor representation in the OB is not fixed but rather varies significantly depending on the respiratory state...
  60. doi Tracheobronchial anatomy and the distribution of inhaled foreign bodies in children
    Nasim Tahir
    Department of Clinical Radiology, St James s University Hospital, Leeds, UK
    Eur J Pediatr 168:289-95. 2009
    Foreign body inhalation is a common and life-threatening emergency, and is most prevalent in young children...
  61. pmc Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax
    Sandip K Datta
    Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:10638-43. 2010
    ..We show that protection against inhalation anthrax by an irradiated spore vaccine depends on CT-mediated induction of IL-17-producing CD4 Th17 cells...
  62. pmc The airway response to deep inspirations decreases with COPD severity and is associated with airway distensibility assessed by computed tomography
    Nicola Scichilone
    Dipartimento di Medicina, Pneumologia, Fisiologia e Nutrizione Umana, Univ of Palermo, 90146 Palermo, Italy
    J Appl Physiol (1985) 105:832-8. 2008
    ....
  63. ncbi Foreign bodies aspirated in children: role of bronchoscopy
    D Divisi
    Thoracic Surgery, G Mazzini Hospital of Teramo, University of L Aquila, Teramo, Italy
    Thorac Cardiovasc Surg 55:249-52. 2007
    ..To examine the diagnostic and therapeutic role of fiber-optic and rigid bronchoscopy in pediatric patients with foreign body inhalations...
  64. pmc Periodicity, mixed-mode oscillations, and quasiperiodicity in a rhythm-generating neural network
    Christopher A Del Negro
    Cellular and Systems Neurobiology Section, Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Biophys J 82:206-14. 2002
    ....
  65. pmc Carbon dioxide inhalation induces dose-dependent and age-related negative affectivity
    Eric J Griez
    Department of Psychiatry and Neuropsychology, University of Maastricht, Maastricht, The Netherlands
    PLoS ONE 2:e987. 2007
    Carbon dioxide inhalation is known to induce an emotion similar to spontaneous panic in Panic Disorder patients. The affective response to carbon dioxide in healthy subjects was not clearly characterized yet.
  66. pmc Second-hand stress: inhalation of stress sweat enhances neural response to neutral faces
    Denis Rubin
    Department of Biomedical Engineering, Bioengineering Building, Room 119, Stony Brook, NY 11794 5281, USA
    Soc Cogn Affect Neurosci 7:208-12. 2012
    ..These results suggest that stress sweat may impact electrocortical activity associated with attention to salient environmental cues, potentially increasing attentiveness to otherwise inconspicuous stimuli...
  67. pmc Effects of pulmonary inhalation on hyperpolarized krypton-83 magnetic resonance T1 relaxation
    K F Stupic
    Sir Peter Mansfield Magnetic Resonance Centre, School of Clinical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK
    Phys Med Biol 56:3731-48. 2011
    ..Various inhalation schemes were devised to study the influence of anatomical dead space upon the measured (83)Kr T(1) relaxation ..
  68. doi Challenges and advances in intubation: rapid sequence intubation
    Sharon Elizabeth Mace
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve, Cleveland, OH 44195, USA
    Emerg Med Clin North Am 26:1043-68, x. 2008
    ..Controversy has arisen regarding various steps in RSI; however, RSI remains the standard of care in emergency medicine airway management...
  69. ncbi North American Summit on Aspiration in the Critically Ill Patient: consensus statement
    Stephen A McClave
    Department of Medicine, University of Louisville School of Medicine, Kentucky 40202, USA
    JPEN J Parenter Enteral Nutr 26:S80-5. 2002
    ..Management strategies for treating aspiration pneumonia are based on degree of diagnostic certainty, time of onset, and host factors...
  70. ncbi Respiratory rhythm generation during gasping depends on persistent sodium current
    Julian F R Paton
    Department of Physiology, Bristol Heart Institute, School of Medical Sciences, University of Bristol, Bristol, UK
    Nat Neurosci 9:311-3. 2006
    ..We provide evidence for hypoxia-driven transformation within the central respiratory oscillator, in which gasping relies on persistent sodium current, whereas eupnea does not depend on this cellular mechanism...
  71. ncbi The anatomical logic of smell
    Thomas A Schoenfeld
    Department of Physiology, Program in Neuroscience, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Trends Neurosci 28:620-7. 2005
    ..Animals can then modify and analyze odor representation further by the dynamic regulation of sniffing...
  72. pmc The Burkholderia pseudomallei Δasd mutant exhibits attenuated intracellular infectivity and imparts protection against acute inhalation melioidosis in mice
    Michael H Norris
    Department of Microbiology, University of Hawaii at Manoa, Manoa, HI, 96822, USA
    Infect Immun 79:4010-8. 2011
    ..was found to be avirulent in BALB/c mice, and mice vaccinated with the mutant were protected against acute inhalation melioidosis. Thus, the B...
  73. doi Radon inhalation protects mice from carbon-tetrachloride-induced hepatic and renal damage
    Takahiro Kataoka
    Graduate School of Health Sciences, Okayama University, 5 1 Shikata cho 2 chome, Kita ku, Okayama Shi, Okayama, 700 8558, Japan
    Inflammation 34:559-67. 2011
    We assessed whether radon inhalation provided protection from carbon tetrachloride (CCl4)-induced hepatic and renal damage in mice...
  74. doi Low frequency oscillometry parameters in COPD patients are less variable during inspiration than during expiration
    Masaru Kubota
    Respiratory Medicine, Kitasato University School of Medicine, Kanagawa 228 8555, Japan
    Respir Physiol Neurobiol 166:73-9. 2009
    ..Thus, the evaluation of IOS parameters may be more accurate during inspiration in COPD patients...
  75. doi Towards a basic endoscopic assessment of swallowing in acute stroke - development and evaluation of a simple dysphagia score
    Rainer Dziewas
    Department of Neurology, University Hospital of Munster, Munster, Germany
    Cerebrovasc Dis 26:41-7. 2008
    ..The purpose of this investigation was to develop and to evaluate an endoscopic scoring system which has the potential to guide dysphagia management in acute stroke patients...
  76. ncbi Inspiratory flow rates at different levels of resistance in elderly COPD patients
    W Janssens
    Respiratory Division, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
    Eur Respir J 31:78-83. 2008
    ....
  77. ncbi Tracheobronchial foreign bodies in children: importance of accurate history and plain chest radiography in delayed presentation
    B Tokar
    Departments of Paediatric Surgery and Radiology, Osmangazi University Faculty of Medicine, Eskisehir, Turkey
    Clin Radiol 59:609-15. 2004
    ..To evaluate the factors associated with delayed diagnosis of foreign body aspiration (FBA) in children and to compare clinical, radiological and bronchoscopic findings in the patients with suspected FBA...
  78. ncbi Allergic reactions to foods by inhalation
    John M James
    Colorado Allergy and Asthma Centers, 1136 East Stuart Street, Suite 3200, Fort Collins, CO 80524, USA
    Curr Allergy Asthma Rep 7:167-74. 2007
    Although allergic reactions to foods occur most commonly after ingestion, inhalation of foods can also be an underlying cause of these reactions...
  79. ncbi Management of suspected foreign body aspiration in children
    G R Dunn
    Department of Ear Nose and Throat Surgery, Western General Hospital, Edinburgh, UK
    Clin Otolaryngol Allied Sci 27:384-6. 2002
    ..Thus, the majority suggest admission, showing a preference for bronchoscopy with a history of organic FB, and observation if inorganic. Unless justified, it may be unacceptable to discharge these patients...
  80. ncbi Assessing a system to capture stray aerosol during inhalation of nebulized liposomal cisplatin
    Bart P H Wittgen
    Department of Pulmonary Diseases, VU University Medical Center, Amsterdam, The Netherlands
    J Aerosol Med 19:385-91. 2006
    ..care personnel working with patients inhaling nebulized liposomal encapsulated SLIT (Sustained-release Lipid Inhalation Targeting) Cisplatin...
  81. pmc Inhalation of Staphylococcus aureus enterotoxin A induces IFN-gamma and CD8 T cell-dependent airway and interstitial lung pathology in mice
    Guruprasaadh Muralimohan
    Department of Immunology, University of Connecticut Health Center, Farmington, CT 06032, USA
    J Immunol 181:3698-705. 2008
    ..Therefore, our results show that IFN-gamma-producing CD8 T cells mediated pulmonary alveolitis and inflammation, which were dependent upon CD4 T cells for their recruitment to the lung...
  82. doi Comparison of inspiratory and expiratory resistance and reactance in patients with asthma and chronic obstructive pulmonary disease
    Paolo Paredi
    Airway Disease Section, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Thorax 65:263-7. 2010
    ..Large inspiratory-expiratory variations in Xrs at 5 Hz (DeltaX5) in an individual have been used as a surrogate marker of expiratory flow limitation...
  83. pmc Chronic LPS inhalation causes emphysema-like changes in mouse lung that are associated with apoptosis
    David M Brass
    Environmental Lung Diseases Research Group, Laboratory of Respiratory Biology, National Heart Lung and Blood Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Am J Respir Cell Mol Biol 39:584-90. 2008
    ..Antineutrophil antiserum-treated mice were partially protected from the lung destruction caused by chronic inhalation of LPS...
  84. ncbi Lung deposition after electronically breath-controlled inhalation and manually triggered conventional inhalation in cystic fibrosis patients
    Elke Köhler
    Department of General Paediatrics and Neonatology, Medical Faculty, Otto von Guericke University, Magdeburg, Wiener Strasse, Germany
    J Aerosol Med 18:386-95. 2005
    ..The relative lung deposition was estimated by inhalation of the marker substance, sodium cromoglycate (SCG), and measurement of urinary excretion of SCG...
  85. ncbi High sensitivity to neuromodulator-activated signaling pathways at physiological [K+] of confocally imaged respiratory center neurons in on-line-calibrated newborn rat brainstem slices
    Araya Ruangkittisakul
    Department of Physiology and Perinatal Research Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Neurosci 26:11870-80. 2006
    ..Our approaches and findings provide the basis for a pharmacological and structure-function analysis of the isolated respiratory center in a histologically well defined substrate at physiological [K+]...
  86. ncbi Bronchodilatory effect of deep inspiration is absent in subjects with mild COPD
    Nicola Scichilone
    Istituto di Medicina Generale e Pneumologia, Cattedra di Malattie dell Apparato Respiratorio, University of Palermo, Palermo, Italy
    Chest 125:2029-35. 2004
    ..To investigate whether the bronchodilatory effect of deep inspiration is impaired in subjects with COPD...
  87. ncbi Relating maximum airway dilation and subsequent reconstriction to reactivity in human lungs
    Lauren D Black
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    J Appl Physiol (1985) 96:1808-14. 2004
    ..We conclude that preventing DIs does not ensure that healthy subjects will transition entirely to an asthmatic-like hyperreactive lung state...
  88. ncbi Three-dimensional computed tomography for detection of tracheobronchial foreign body aspiration in children
    H J Huang
    Department of Surgery, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua, 500, Taiwan
    Pediatr Surg Int 24:157-60. 2008
    ..These benefits may prompt further studies to determine whether CT could be used to reduce the number of unnecessary bronchoscopies performed in children being evaluated for FBA...
  89. ncbi A case of naturally acquired inhalation anthrax: clinical care and analyses of anti-protective antigen immunoglobulin G and lethal factor
    James J Walsh
    Section of Pulmonary and Critical Care Medicine, Guthrie Clinic, Sayre, PA, USA
    Clin Infect Dis 44:968-71. 2007
    This report describes the first case of naturally acquired inhalation anthrax in the United States since 1976. The patient's clinical course included adjunctive treatment with human anthrax immunoglobulin...
  90. ncbi Which commercial thickening agent do patients prefer?
    Catherine Macqueen
    Hammersmith Hospital, London, United Kingdom
    Dysphagia 18:46-52. 2003
    ..By offering the more palatable thickening agents in drink flavors that patients enjoy, we would hope to improve compliance with speech and language therapy recommendations, thereby reducing the patient's risk of aspiration...
  91. ncbi Inspiratory flow rates during hard work when breathing through different respirator inhalation and exhalation resistances
    Karen Coyne
    US Army Edgewood CB Center, Aberdeen Proving Ground, MD 21010, USA
    J Occup Environ Hyg 3:490-500. 2006
    ..aerobic capacity until exhaustion while wearing an air-purifying respirator with one of eight combinations of inhalation and exhalation resistance...
  92. doi Improvement of brain tissue oxygenation by inhalation of carbogen
    M Ashkanian
    Center of Functionally Integrative Neuroscience, Aarhus University, Aarhus University Hospital, Aarhus C, Denmark
    Neuroscience 156:932-8. 2008
    ..we used positron emission tomography (PET) to measure CBF and cerebral metabolic rate of oxygen (CMRO(2)) during inhalation of test gases (O(2), CO(2), carbogen and atmospheric air) in 10 healthy volunteers...
  93. ncbi Deep inhalation prevents the respiratory elastance response to methacholine in rats
    Cyril Schweitzer
    Laboratoire de Physiologie, Faculte de Medecine, F 54505 Vandoeuvre les Nancy, France
    Pediatr Res 59:646-9. 2006
    The bronchodilator effect of deep inhalation (DI) may be assessed from the time course of respiratory system resistance (Rrs) and reactance (Xrs) measured by the forced oscillation technique at a single frequency...
  94. ncbi Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease
    Nicholas L Mills
    Centre for Cardiovascular Science, Edinburgh University, Edinburgh, Sweden
    N Engl J Med 357:1075-82. 2007
    ..We conducted a controlled exposure to dilute diesel exhaust in patients with stable coronary heart disease to determine the direct effect of air pollution on myocardial, vascular, and fibrinolytic function...
  95. ncbi A comparison between single- and double-breath vital capacity inhalation induction with 8% sevoflurane in children
    Kok Yuen Ho
    Department of Anaesthesia Paediatrics, KK Women s and Children s Hospital, Singapore
    Paediatr Anaesth 14:457-61. 2004
    This study was conducted to determine if a double-breath (DB) vital capacity (VC) rapid inhalation induction using immediate high-inspired concentration of sevoflurane is as well tolerated as a single-breath (SB) technique and if it ..
  96. ncbi Inhaled foreign bodies in adolescents and adults
    S M Tariq
    Unit of Respiratory Medicine, Department of Medicine, Sultan Qaboos University Hospital, Muscat
    Monaldi Arch Chest Dis 63:193-8. 2005
    Accidental foreign body inhalation is not uncommon. The incidence is high in children, especially the very young ones...
  97. ncbi Can hypertonic saline inhalation influence preformed chemokine and mediator release in induced sputum of chronic obstructive pulmonary disease patients? Comparison with isotonic saline
    S Cianchetti
    Cardiothoracic Department, Pneumology Section, Pisa, Italy
    Clin Exp Allergy 37:1819-26. 2007
    ..Chronic airway inflammation, a major feature of chronic obstructive pulmonary disease (COPD), is associated with an activation of inflammatory and resident cells, which in turn makes them more prompt to respond to further stimuli...
  98. ncbi Inhalation of carbon monoxide prevents liver injury and inflammation following hind limb ischemia/reperfusion
    Michael C Ott
    Victoria Research Lab, 6th Floor, Rm A6 105, 800 Commissioners Rd, London, ON, Canada N6A 4G4
    FASEB J 19:106-8. 2005
    ..b>Inhalation of CO alone did not alter any microcirculatory or inflammatory parameters...
  99. pmc Kinetics of lethal factor and poly-D-glutamic acid antigenemia during inhalation anthrax in rhesus macaques
    Anne E Boyer
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Infect Immun 77:3432-41. 2009
    ..We report the characterization of LF, PA, and PGA levels during the course of inhalation anthrax in five rhesus macaques...
  100. ncbi The Last Word: Point:Counterpoint authors respond to commentaries on "the parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal"
    Jack L Feldman
    J Appl Physiol 101:689. 2006
  101. ncbi Deep inspiration and airway smooth muscle adaptation to length change
    Lu Wang
    Department of Physiology, University of Manitoba, Winnipeg, MB, Canada
    Respir Physiol Neurobiol 137:169-78. 2003
    ..In this brief review we focus on the mechanical consequences of DI on the ASM. We suggest that a failure of plastic rearrangement of the contractile apparatus following DI is at the basis of the abnormal response to DI in asthma...

Research Grants77

  1. Anti-Inflammatory Glycosaminoglycan Ethers for Treatment of Periodontitis
    JUSTIN RODNEY SAVAGE; Fiscal Year: 2011
    ..AGEs from high blood sugar or from inhalation of AGES from tobacco products amplify inflammation by ligation of the cell-surface receptor for AGEs, or RAGE...
  2. The influence of air pollution mixtures on biomarkers of airway oxidative stress
    Roby Greenwald; Fiscal Year: 2013
    ..Since the elevated ventilation rate associated with physical activity leads to increased inhalation of ambient oxidants, the investigatorswill monitor activity intensity using a wearable device that contains a ..
  3. Inhibition of human neutrophil function by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2012
    ..Indeed, inhalation of as few as ten organisms is sufficient to cause severe pneumonic disease, tissue necrosis and death...
  4. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Specific aims: 1) Evaluate inhalation exposures associated with use of diesel and biodiesel blend-fueled equipment in an underground mine;2) Evaluate ..
  5. A Thioredoxin Mimetic for Radiocontrast Nephropathy
    GARRY JOHN SOUTHAN; Fiscal Year: 2012
    ..In a murine LD100 model of severe redox stress induced by acute Cl2 gas inhalation, post-insult administration of R-901 reduced pulmonary neutrophil infiltration by 50%...
  6. A Bifunctional Katp Channel Activator and Redox Mimetic for BPD
    Kanneganti Murthy; Fiscal Year: 2013
    ..In a murine model of hypohalous redox lung injury induced by Cl2 inhalation, R-801 resuscitation reduced histologic injury, diminished neutrophil (PMN) infiltration, blocked nuclear ..
  7. A Novel Thioredoxin Mimetic Prodrug for Prevention of Bronchopulmonary Dysplasia
    Prakash Jagtap; Fiscal Year: 2013
    ..In a murine LD60 model of redox stress, induced by acute Cl2 inhalation, post-insult administration of R-901 eliminated all mortality...
  8. Resuscitation of smoke inhalation and burn injury with a thioredoxin mimetic
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Smoke inhalation and burn injury (SIBI) induces acute lung injury (ALI) via the generation of toxic free radical and oxidant species that, in turn, trigger DNA single strand breaks (SSB) throughout ..
  9. FUNCTIONAL PROPERTIES OF HEMOGLOBINS AND MYOGLOBINS
    John S Olson; Fiscal Year: 2010
    ..other aerobic tissues from inhibition of mitochondrial respiration during inflammation, sepsis, and nitric oxide inhalation. Our proposed studies will provide: (a) alternative biophysical mechanisms for O2 stabilization, rapid ligand ..
  10. Durable Visible Light-activated Antivral Coatings for Fabrics Used for Personal P
    JOSEF STEPHAN SCHNEIDER; Fiscal Year: 2011
    ..equipment (PPE) such as a respirator masks to minimize contact transmission onto facial skin or airborne inhalation of pathogenic organisms...
  11. GI Endotoxin as an Environmental Trigger in an alpha-Synuclein Transgenic Mouse
    Robert L Nussbaum; Fiscal Year: 2012
    ..Exposure to the environmental agents implicated in PD is probably via the gastrointestinal (GI) tract (although inhalation exposing the olfactory nerves is also possible), suggesting that the enteric nervous system (ENS), which would ..
  12. PARP Inhibitor and Redox Catalyst for Ventilatory Trauma
    Prakash Jagtap; Fiscal Year: 2013
    ..and Cl2 inhalational lung injury, resuscitation with R-503 begun after the onset of zymosan instillation or Cl2 inhalation reduced neutrophil (PMN) infiltration by 65% and histologic lung injury by 80% (p<0.001)...
  13. Mechanism of Irradiation Pulmonary Fibrosis
    Joel S Greenberger; Fiscal Year: 2012
    ..The first specific aim tests the hypothesis that inhalation MnSOD-PL gene therapy facilitates lung irradiation through enhancement of migration of marrow origin reparative ..
  14. Genetics of Cryptococcus sexual reproduction
    Joseph Heitman; Fiscal Year: 2013
    ..Our studies further demonstrate that spores produced by sex are infectious following inhalation, and thus unisexual reproduction may be the source of human infections...
  15. Pulmonary effects of biomass fuel indoor PM from rural India
    Shyam Biswal; Fiscal Year: 2013
    ..Although an inhalation exposure model is more realistic, airway instillation has been demonstrated to be a very effective model for ..
  16. Role of Physico-chemical Properties in the Reprotoxicity of Inhaled Cd NP.
    JUDITH TERRY ZELIKOFF; Fiscal Year: 2010
    ..e., low birth weight [LBW], and pre-term delivery [PTD]), a study is proposed to determine how inhalation of Cd-bearing NP (as CdO and CdTe) might impair fetal stability in utero, and how these effects are related to ..
  17. Development of an effective therapy against post-exposure Anthrax
    Maurizio Pellecchia; Fiscal Year: 2010
    ..Although cutaneous Anthrax is rarely lethal, inhalation Anthrax is dangerous and usually fatal...
  18. Mechanisms for Cardiovascular Effects of air pollutants: Effect of Age and Sex
    BRITT HOLMEN; Fiscal Year: 2010
    ..This proposal will establish controlled production of engine emissions to be used in inhalation studies...
  19. Repair of Airway Epithelium Following Chlorine Lung Injury
    Gary W Hoyle; Fiscal Year: 2011
    ..foster the development of therapeutic agents that could be used to stimulate resolution of lung injury following inhalation of toxic chemicals...
  20. TNF-alpha Signaling in Silica-Induced Lung Fibrosis
    Luis A Ortiz; Fiscal Year: 2012
    ..PROJECT NARRATIVE: The term silicosis refers to the fibronodular lung disease caused by long-term inhalation of free silica...
  21. Identification of new compounds against fungal microbes
    Maurizio Del Poeta; Fiscal Year: 2013
    ..lacking the final enzyme for the synthesis of glucosylceramide (glucosylceramide synthase 1 or Gcs1), after inhalation, was confined in the lung granuloma and, thus, did not reach the bloodstream and did not disseminate to the ..
  22. Novel therapeutics for vesicants and toxic inhaled chemicals (U54)
    Carl W White; Fiscal Year: 2013
    ..In lung, CEES caused bronchial vascular injury/leak. Airway obstructive fibrin-containing casts formed after inhalation exposures to CEES or SM, and similar lesions were apparent after chlorine (400 ppm)...
  23. Expression signatures of TB-specific memory responses within the human lung
    Richard F Silver; Fiscal Year: 2013
    ..Mycobacterium tuberculosis (Mtb), the organism that causes TB, is a respiratory pathogen spread via inhalation of infectious airborne particles...
  24. Dysregulation of the inflammatory response by Francisella tularensis
    Lee Ann H Allen; Fiscal Year: 2013
    ..fatal zoonosis of humans caused by the facultative intracellular bacterium, Francisella tularensis, and inhalation of as few as ten organisms is sufficient to cause severe pneumonic disease, tissue necrosis, and death...
  25. ACTIVATED MACROPHAGES AND OZONE TOXICITY
    DEBRA LYNN LASKIN; Fiscal Year: 2012
    ..Down-regulation of Cav-1 after ozone inhalation is associated with activation of the (-catenin/cyclin D1 pro-mitogenic signaling pathway...
  26. AGE-RELATED ALTERATION OF LEYDIG CELL REDOX ENVIRONMENT A RISK FACTOR FOR SUSCEPT
    Kassim Traore; Fiscal Year: 2013
    ..Human exposures to DEHP occur via food, inhalation, dermal contact and medical procedures (e.g...
  27. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) IN MAMMALS
    Jacob McDonald; Fiscal Year: 2013
    ..Occupational exposure to DTBBA in the rubber industry may occur through inhalation and dermal contact, but the extent of dermal absorption is not known...
  28. S-Nitrosylated Hemoglobin and Ischemic Brain Injury
    David Warner; Fiscal Year: 2010
    ..rat middle cerebral artery occlusion (MCAO) model, we will 1) Define acute effects of 20 ppm ethyl nitrite inhalation on absolute CBF during and after filament MCAO and measure amount of tissue at risk for cerebral infarction as a ..
  29. Predictive Toxicological Paradigms to Establish Inhalation Toxicology Models
    ANDRE ELIAS NEL; Fiscal Year: 2010
    ..Vince Castranova at NIOSH and Dr. Lutz Mddler at Bremen University (Germany), aim to establish a mouse inhalation toxicology model to screen combinatorial nanomaterials libraries that are linked to mechanistic injury pathways ..
  30. ENHANCEMENT OF CORONARY CONSTRICTION BY COMBUSTION-SOURCE AIR TOXICS
    Matthew J Campen; Fiscal Year: 2012
    ..ECG and vascular abnormalities in ApoE-/- mice occurred when exposed by inhalation to fresh diesel or gasoline exhaust, but not aged, resuspended road dust, suggest that certain compounds in ..
  31. Routine Aspiration of Residual Gastric Contents in Very Low Birth Weight Infants
    Leslie A Parker; Fiscal Year: 2013
    ..Public Health Relevance: This research has potential to influence health policy and practices that may directly translate to improved nutritional and health outcomes for premature VLBW infants. ..
  32. Bifunctional Redox Agent for the Treatment of PPHN
    GARRY JOHN SOUTHAN; Fiscal Year: 2011
    ..Existing therapy for this condition involves the inhalation of nitric oxide gas, but this proves ineffective in more than a third of infants...
  33. Development of Inhaled Vancomycin for Treatment of MRSA Infections in CF
    Taneli Jouhikainen; Fiscal Year: 2012
    ..innovative particle coating technology, enabling for the first time the development of a practical and effective inhalation treatment of pulmonary MRSA infection...
  34. Diesel Exhaust Particle Effects on Human Immunity to Mycobacterium tuberculosis
    Stephan K Schwander; Fiscal Year: 2010
    ..Our unique preliminary studies in healthy volunteers after DEP inhalation exposure show increased M.tb-induced IFN-gamma, and decreased M.tb-induced IL-6 and IL-10 release...
  35. Effects of ozone exposure on expression and function of surfactant protein D
    Angela Haczku; Fiscal Year: 2010
    ..Our studies showed that inhalation of O3, a common air pollutant, induced a significant exacerbation of the asthmatic changes in allergen ..
  36. Mechanisms of airborne particulate matter induced thrombosis
    Gokhan M Mutlu; Fiscal Year: 2013
    ..Conversely, inhalation of a long acting [unreadable]2-agonist (formoterol) augmented the PM-induced release of IL-6 and the resulting ..
  37. 2-Amino-9H-pyrido[2,3-b]indole: a potential colorectal carcinogen formed in tobac
    Robert J Turesky; Fiscal Year: 2013
    ..Dosing will be done orally or by inhalation to assess the impact of dose routes on DNA damage in the colon...
  38. Influenza therapy by Au-nanorod 5'PPP-NS1-siRNA/cDNA targeting of bronchial cells
    Paul R Knight; Fiscal Year: 2010
    ..well suited for these treatment strategies as direct contact with the environment provides a portal for inhalation administration of cDNA and siRNA conjugated nanoplexes...
  39. Inhibition of lung defense by air pollutant particulates
    LISA KATHLEEN RYAN; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Vanadium inhalation has long been associated with infectious lung diseases in metal workers and boilermakers and recently has been ..
  40. Tie2 Activation for the Treatment of Chemical-Induced Acute Lung Injury
    Christopher D Kontos; Fiscal Year: 2013
    ..small molecules that can be advanced to subsequent pharmacology/toxicology testing and development as treatments for acute lung injury resulting from the inhalation of phosgene and similar toxic industrial chemicals.
  41. Role of the Aryl Hydrocarbon Receptor in Lung Inflammation
    PATRICIA JANET SIME; Fiscal Year: 2012
    ..Project Narrative: Lung inflammatory conditions induced by the inhalation of cigarette smoke and other toxicants are the cause of significant morbidity and mortality world-wide...
  42. Brain Oxygen Metabolism and Hemodynamic Impairment in Multiple Sclerosis
    Yulin Ge; Fiscal Year: 2013
    ..rate of oxygen (CMRO2) and a patient-comfortable blood-oxygen-level-dependent (BOLD) paradigm using CO2 inhalation to measure CVR...
  43. Investigating gene x environment interaction using human exposures to O3 & LPS
    David B Peden; Fiscal Year: 2010
    ..4 ppm ozone for 2 hours, and inhalation of a 20,000 units of endotoxin...
  44. Mucosal innate immune defense to Rift Valley fever virus
    Amy G Hise; Fiscal Year: 2010
    ..Transmission to humans can occur either by mosquito bite, food contamination or aerosol inhalation during exposure to body fluids of RVFV-infected livestock...
  45. Biomimetic Microsystem for High Throughput Evaluation of Engineered Nanomaterials
    Robert M Worden; Fiscal Year: 2010
    ..Due to their small size and potential for airborne dispersion, inhalation exposure to ENM might contribute to the increased incidence and/or exacerbation of allergic airway disease...
  46. TYPE II SECRETION AND LEGIONELLA PNEUMOPHILA INFECTION
    Nicholas P Cianciotto; Fiscal Year: 2013
    ..The bacterium is ubiquitous in natural and man-made water systems and infects the lungs after the inhalation of contaminated aerosols...
  47. Ozone, apoE4, aging, and Alzheimer's disease
    Rui Ming Liu; Fiscal Year: 2013
    ..Although O3 is traditionally considered to be a lung toxicant, emerging evidence indicates that O3 inhalation also causes oxidative stress and pathological changes in other tissues/organs beyond the respiratory system...
  48. Enhancement of Coronary Constriction by Volatile Organic Air Toxics
    Matthew J Campen; Fiscal Year: 2013
    ..We postulate that inflammatory endothelial activation arises following inhalation of air pollutants due to oxidative modifications of blood components, and reflects a common mode of action for ..
  49. In vitro and in vivo efficacy of liposomal ciprofloxacin formulations against Myc
    Igor Gonda; Fiscal Year: 2013
    ..objective of this project is test the efficacy of two new formulations of ciprofloxacin (Ciprofloxacin for Inhalation, CFI, Lipoquin(R);and Dual Release Ciprofloxacin for Inhalation, DRCFI, Pulmaquin(R)), developed recently ..
  50. Cancer Mortality among Military Participants at U.S. Nuclear Weapons Tests
    JOHN DUNNING BOICE; Fiscal Year: 2013
    ..specific cancer risks following protracted low-dose exposure to external and internal radiation, including the inhalation and ingestion of plutonium, uranium and radioactive fission products...
  51. Liquid Crystal-Based End-of-Service-Life-Indicator for Toluene Vapor
    BHARAT R ACHARYA; Fiscal Year: 2011
    ..To minimize the risk of exceeding the adsorption capacity of the carbon, which would result in breakthrough and inhalation of organic vapors, NIOSH has recommended the use of end-of-service life indicators (ESLI) in APRs...
  52. Hazard Assessment and Risk Estimation of Inhaled Nanomaterials Exposure
    Gunter Oberdorster; Fiscal Year: 2010
    ..respiratory tract and to quantitate ENM translocation- related effects in secondary tissues following realistic inhalation exposure using a multidisciplinary tiered testing approach...
  53. Microvascular Health and Nanoparticle Exposure
    Timothy R Nurkiewicz; Fiscal Year: 2010
    ..Concurrently, we are the only laboratory in this area/topic to directly evaluate microvascular health after inhalation exposure to such nanoparticles...
  54. DNA cross-linking by diepoxybutane
    Natalia Y Tretyakova; Fiscal Year: 2013
    ..Quantify bifunctional DEB-DNA lesions in vivo following inhalation exposure to 1,3-butadiene...
  55. Absorption, distribution, metabolism, excretion (ADME) of chemicals in mammals
    Rochelle W Tyl; Fiscal Year: 2009
    ..acid;n-butylparaben;Radiolabeled compounds;In vivo;In vitro;Dermal;Gavage;IV;Inhalation;Mass balance; Abstract;The goal of this contract is to provide support of National Toxicology Program (NTP) ..
  56. Toxic metals and ion channels in cigarette-smoke induced COPD
    ESTELLE A CORMET BOYAKA; Fiscal Year: 2010
    ..Cadmium is also present in contaminated air, food and water. Cadmium inhalation has been reported to be associated with development of COPD and lung cancer...
  57. Research on inhalation toxicology of environmental chemicals
    ROBERT O'CONNER; Fiscal Year: 2012
    ..During FY2011, 1873 animals (~20 mouse strains and 3 rat strains) were received and maintained at the Inhalation facility for these studies. Most of these animals were purchased using contract funds...
  58. Single Cell Analysis of EGFR Activity in Human Airway Cells Exposed to Pollutants
    RYAN MATTHEW PHILLIPS; Fiscal Year: 2013
    ..While it is thought that EGFR plays an important role in lung inflammation due to pollutant inhalation, direct measurements of EGFR activity in live human airway samples are not currently feasible...
  59. Countermeasures for chlorine-induced airway fibrosis
    Gary W Hoyle; Fiscal Year: 2013
    ..Acute effects of chlorine inhalation include dyspnea, hypoxemia, pneumonitis, and pulmonary edema...
  60. Innate Immune Sensing of Rift Valley Fever Virus
    Amy G Hise; Fiscal Year: 2010
    ..In such settings, transmission to humans occurs either by insect bite or aerosol inhalation, which occurs during exposure to body fluids of RVFV-infected animals...
  61. Aerosol Delivery of a Recombinant Butyrylcholinesterase "BioShield" to Protect Ag
    YVONNE J ROSENBERG; Fiscal Year: 2012
    ..the OP's entry into the systemic circulation and avoiding the respiratoty usually associated with inhalation exposure...
  62. MR-PET for a Small Animal Imaging Center
    Jason A Koutcher; Fiscal Year: 2010
    ..temperature and cardiac monitoring to decrease morbidity and improve image quality, in addition to a port for inhalation anesthesia and other gases...
  63. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2009
    ..contract includes a varied array of test materials and classes of test materials that are to be tested via the inhalation route of exposure, some are vapors while others are liquid or solid aerosols...
  64. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2011
    ..contract includes a varied array of test materials and classes of test materials that are to be tested via the inhalation route of exposure, some are vapors while others are liquid or solid aerosols...
  65. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2010
    ..contract includes a varied array of test materials and classes of test materials that are to be tested via the inhalation route of exposure, some are vapors while others are liquid or solid aerosols...
  66. Lung Injury and Shock Pathogenesis in Y. pestis Sepsis
    ANDREW LECHNER; Fiscal Year: 2006
    ..acute lung injury (ALI) and septic shock originating as pneumonic plague that will dominate epidemics following inhalation of Y. pestis as a weapon of bioterrorism. To identify the molecular pathogenesis of Y...
  67. Allergic asthma and chromium exposure
    Steven R Patierno; Fiscal Year: 2010
    ..To date, however, a direct causal association between inhalation of Cr(VI) and development of allergic asthma has not been established...
  68. Nasal dosimetry of diacetyl and butyric acid vapors
    John Morris; Fiscal Year: 2005
    The inhalation toxicity of inspired materials is critically dependent on their inhalation dosimetric patterns; this may be particularly true for the vapors derived from artificial butter flavorings...
  69. Nitric Oxide Releasing Topical Gel for Burn Wound Healing
    ANJAL SHARMA; Fiscal Year: 2007
    ..Most current nitric oxide therapies (other than inhalation therapies) involve systemic or topical treatments with drugs designed to stimulate inducible nitric oxide ..
  70. DRUG SELF-ADMINISTRATION BY INHALATION IN THE PRIMATE
    Ronald Wood; Fiscal Year: 1991
    ..The alkyl benzenes comprise 30 to 40 of gasoline, which is abused by inhalation, and are present in glues, paint thinner, and solvents; concentration-effect curves will be determined for alkyl ..
  71. Therapeutics against chemical threat induced respiratory toxicity
    MADHUSOODANA NAMBIAR; Fiscal Year: 2009
    ..We propose to investigate the respiratory toxicity and lung injury following inhalation exposure to the deadly chemical threat agent sarin in animal models...
  72. GENERAL ANESTHETICS AND CLONED VOLTAGE-GATED CHANNELS
    ANA CORREA; Fiscal Year: 2000
    ..b>Inhalation general anesthetics (GA), fundamental aides in surgical anesthesia, induce both but not without displaying some ..
  73. SULFUR OXIDES EFFECTS ON LUNG FUNCTION IN ASTHMATICS
    Jane Koenig; Fiscal Year: 1991
    ..Thus the overall objective of this project is to elucidate further the potential human toxicity of inhalation of these wide spread serious air pollutants...
  74. PARS inhibitor therapy of smoke inhalation injury
    Prakash Jagtap; Fiscal Year: 2001
    Smoke inhalation and burn injury induce an inflammatory pneumonitis that may progress to severe respiratory failure. Current treatment options are limited to supportive measures...
  75. PARS inhibitor therapy for smoke inhalation
    Andrew Salzman; Fiscal Year: 2004
    Smoke inhalation is a major co-morbid factor in thermal injury. Therapy of smoke inhalation is supportive -there are no specific countermeasures to protect the lung from injury...
  76. The Role of RAGE in Asbestosis
    Tim Oury; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Asbestosis, a form of pneumoconiosis caused by inhalation of asbestos fibers, is the prototype of diseases caused by inhalation of mineral fibers...
  77. An Inhalation Model of Q Fever in Guinea Pigs
    Kasi Russell; Fiscal Year: 2005
    ..Few studies have utilized aerosol infection, and none have evaluated the effect of inhalation dose on clinical disease...