exhalation

Summary

Summary: The act of BREATHING out.

Top Publications

  1. ncbi Exhaled nitric oxide in pulmonary diseases: a comprehensive review
    Peter J Barnes
    Airway Disease Section, Imperial College London, National Heart and Lung Institute, London, England
    Chest 138:682-92. 2010
  2. pmc Noninvasive detection of lung cancer by analysis of exhaled breath
    Amel Bajtarevic
    Department of Operative Medicine, Innsbruck Medical University, A 6020 Innsbruck, Austria
    BMC Cancer 9:348. 2009
  3. pmc Influenza virus in human exhaled breath: an observational study
    Patricia Fabian
    Work Environment Department, University of Massachusetts Lowell, Lowell, Massachusetts, United States of America
    PLoS ONE 3:e2691. 2008
  4. ncbi Diagnosing lung cancer in exhaled breath using gold nanoparticles
    Gang Peng
    Department of Chemical Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    Nat Nanotechnol 4:669-73. 2009
  5. ncbi How far droplets can move in indoor environments--revisiting the Wells evaporation-falling curve
    X Xie
    Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China
    Indoor Air 17:211-25. 2007
  6. pmc Proteomics as a method for early detection of cancer: a review of proteomics, exhaled breath condensate, and lung cancer screening
    Dean H Conrad
    Inflammatory Diseases Research Unit, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
    J Gen Intern Med 23:78-84. 2008
  7. ncbi Calcium and magnesium in exhaled breath condensate of children with endogenous and exogenous airway acidification
    S Banovic
    Department for Clinical Laboratory Diagnosis, Srebrnjak Children s Hospital, Zagreb, Croatia
    J Asthma 48:667-73. 2011
  8. pmc Effects of salbutamol on exhaled breath condensate biomarkers in acute lung injury: prospective analysis
    Oriol Roca
    Intensive Care Department General Area, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, C P 08035 Barcelona, Spain
    Crit Care 12:R72. 2008
  9. pmc Qualitative real-time schlieren and shadowgraph imaging of human exhaled airflows: an aid to aerosol infection control
    Julian W Tang
    Department of Laboratory Medicine, National University Hospital, Singapore, Singapore
    PLoS ONE 6:e21392. 2011
  10. ncbi Comparability of a hand-held nitric oxide analyser with online and offline chemiluminescence-based nitric oxide measurement
    Barbara Schiller
    Division of Pediatric Intensive Care and Pulmonology, University Children s Hospital of Basel, Basel, Switzerland
    Pediatr Allergy Immunol 20:679-85. 2009

Detail Information

Publications331 found, 100 shown here

  1. ncbi Exhaled nitric oxide in pulmonary diseases: a comprehensive review
    Peter J Barnes
    Airway Disease Section, Imperial College London, National Heart and Lung Institute, London, England
    Chest 138:682-92. 2010
    ..Monitoring FeNO in pulmonary hypertension and cystic fibrosis has opened up a window to the role NO may play in their pathogenesis and possible clinical benefits in the management of these diseases...
  2. pmc Noninvasive detection of lung cancer by analysis of exhaled breath
    Amel Bajtarevic
    Department of Operative Medicine, Innsbruck Medical University, A 6020 Innsbruck, Austria
    BMC Cancer 9:348. 2009
    ..An early non-invasive diagnosis of lung cancer would improve prognosis and enlarge treatment options. Analysis of exhaled breath would be an ideal diagnostic method, since it is non-invasive and totally painless...
  3. pmc Influenza virus in human exhaled breath: an observational study
    Patricia Fabian
    Work Environment Department, University of Massachusetts Lowell, Lowell, Massachusetts, United States of America
    PLoS ONE 3:e2691. 2008
    ..Recent studies suggest that humans exhale fine particles during tidal breathing but little is known of their composition, particularly during infection...
  4. ncbi Diagnosing lung cancer in exhaled breath using gold nanoparticles
    Gang Peng
    Department of Chemical Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    Nat Nanotechnol 4:669-73. 2009
    ..Our results show that sensors based on gold nanoparticles could form the basis of an inexpensive and non-invasive diagnostic tool for lung cancer...
  5. ncbi How far droplets can move in indoor environments--revisiting the Wells evaporation-falling curve
    X Xie
    Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China
    Indoor Air 17:211-25. 2007
    ..PRACTICAL IMPLICATIONS: Our study reveals that for respiratory exhalation flows, the sizes of the largest droplets that would totally evaporate before falling 2 m away are between 60 and ..
  6. pmc Proteomics as a method for early detection of cancer: a review of proteomics, exhaled breath condensate, and lung cancer screening
    Dean H Conrad
    Inflammatory Diseases Research Unit, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia
    J Gen Intern Med 23:78-84. 2008
    ..This perspective will explore the potential of applying proteomics to the EBC from lung cancer patients as an example of detecting potential biomarkers of disease and progression...
  7. ncbi Calcium and magnesium in exhaled breath condensate of children with endogenous and exogenous airway acidification
    S Banovic
    Department for Clinical Laboratory Diagnosis, Srebrnjak Children s Hospital, Zagreb, Croatia
    J Asthma 48:667-73. 2011
    ..e., with endogenous acidification) and children with gastroesophageal reflux disease, GERD (i.e., with exogenous acidification)...
  8. pmc Effects of salbutamol on exhaled breath condensate biomarkers in acute lung injury: prospective analysis
    Oriol Roca
    Intensive Care Department General Area, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, C P 08035 Barcelona, Spain
    Crit Care 12:R72. 2008
    ..Biomarkers in exhaled breath condensate (EBC) were used to study the effects of salbutamol on lung inflammation in mechanically ventilated patients with ALI...
  9. pmc Qualitative real-time schlieren and shadowgraph imaging of human exhaled airflows: an aid to aerosol infection control
    Julian W Tang
    Department of Laboratory Medicine, National University Hospital, Singapore, Singapore
    PLoS ONE 6:e21392. 2011
    ....
  10. ncbi Comparability of a hand-held nitric oxide analyser with online and offline chemiluminescence-based nitric oxide measurement
    Barbara Schiller
    Division of Pediatric Intensive Care and Pulmonology, University Children s Hospital of Basel, Basel, Switzerland
    Pediatr Allergy Immunol 20:679-85. 2009
    ..FeNO values obtained using the chemiluminescence NO analyser, the portable NIOX MINO system and the offline collection technique show between-method agreement within clinically acceptable range...
  11. ncbi Time-frequency detection and analysis of wheezes during forced exhalation
    Antoni Homs-Corbera
    Department of Automatic Control ESAII, Biomedical Engineering Research Center CREB, Technical University of Catalonia UPC, 08028 Barcelona, Spain
    IEEE Trans Biomed Eng 51:182-6. 2004
    ..Automatic measurements were compared with clinical auscultation for forced exhalation segments from 1.2 to 0 liters/second (l/s)...
  12. pmc Elevated airway purines in COPD
    Charles R Esther
    Department of Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Chest 140:954-60. 2011
    ..However, accurate airway surface purine measurements can be confounded by stimulation of purine release during collection of typical respiratory samples...
  13. ncbi Exhaled nitric oxide discriminates children with and without allergic sensitization in a population-based study
    T C Yao
    Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan
    Clin Exp Allergy 41:556-64. 2011
    ..Fraction of exhaled nitric oxide (FeNO) as a biomarker of airway inflammation in children warrants better clarification...
  14. ncbi Characterizing exhaled airflow from breathing and talking
    Jitendra K Gupta
    National Air Transportation Center of Excellence for Research in the Intermodal Transport Environment, School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN 47906 2088, USA
    Indoor Air 20:31-9. 2010
    ..The flow rates can be calculated by physiological parameters of a subject. The direction of the exhalation jet did not vary much between subjects and the area of mouth/nose opening could be regarded as a constant...
  15. pmc A comparison of oxidative stress in smokers and non-smokers: an in vivo human quantitative study of n-3 lipid peroxidation
    Basant K Puri
    MRI Unit, MRC Clinical Sciences Centre, Imaging Sciences Department, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK
    BMC Psychiatry 8:S4. 2008
    ..The aim was to carry out the first study of the relationship of smoking in humans to the level of n-3 lipid peroxidation indexed by the level of ethane in exhaled breath...
  16. ncbi Exhaled nitric oxide and asthma control: a longitudinal study in unselected patients
    A Michils
    Chest Dept, CUB Erasme, 808 Route de Lennik, B 1070 Brussels, Belgium
    Eur Respir J 31:539-46. 2008
    ..Forced expiratory volume in one second had little additional value in assessing asthma control...
  17. ncbi Assessment of exhaled breath condensate pH in exacerbations of asthma and chronic obstructive pulmonary disease: A longitudinal study
    Balazs Antus
    Department of Pathophysiology, National Koranyi Institute of TB and Pulmonology, Budapest, Hungary
    Am J Respir Crit Care Med 182:1492-7. 2010
    ..Exhaled breath condensate pH has been proposed as a noninvasive marker of airway inflammation. However, due to standardization difficulties in pH measurement techniques, different pH readings were obtained in previous studies...
  18. ncbi The effect of ambient air pollution on exhaled nitric oxide in the Children's Health Study
    K Berhane
    Dept of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9011, USA
    Eur Respir J 37:1029-36. 2011
    ..In summary, short-term increases in PM₂.₅, PM₁₀ and O₃ were associated with airway inflammation independent of asthma and allergy status, with PM₁₀ effects significantly higher in the warm season...
  19. pmc Inhaling to mitigate exhaled bioaerosols
    David A Edwards
    Harvard University, 322 Pierce Hall, 29 Oxford Street, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 101:17383-8. 2004
    ..In vitro and in vivo experiments with saline and surfactants suggest that the mechanism of action of the nebulized saline relates to modification of the physical properties of the airway-lining fluid, notably surface tension...
  20. ncbi Detection of expiratory flow limitation in COPD using the forced oscillation technique
    R L Dellaca
    TBMLab, Dipartimento di Bioingegneria, Politecnico di Milano University, Milan, Italy
    Eur Respir J 23:232-40. 2004
    ..Within-breath respiratory system reactance provides an accurate, reliable and noninvasive technique to detect expiratory flow limitation in patients with chronic obstructive pulmonary disease...
  21. ncbi A study of the volatile organic compounds exhaled by lung cancer cells in vitro for breath diagnosis
    Xing Chen
    Biosensor National Special Laboratory, Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of National Education Ministry, Zhejiang University, Hangzhou PR China
    Cancer 110:835-44. 2007
    ....
  22. ncbi Exhaled breath condensate biomarkers in COPD
    Z L Borrill
    Medicines Evaluation Unit, Langley Building, The University of Manchester, Wythenshawe Hospital, Southmoor Rd, Manchester M23 9QZ, UK
    Eur Respir J 32:472-86. 2008
    ....
  23. ncbi Exhaled breath condensate (EBC) biomarkers in pulmonary fibrosis
    Sharron Chow
    Department of Pathology, Centre for Infection and Inflammation Research, School of Medical Sciences, University of New South Wales, Kensington, Australia
    J Breath Res 6:016004. 2012
    ..In conclusion, inflammatory and oxidative stress biomarkers are raised in patients with PF compared with controls. EBC may be useful for detecting and monitoring lung inflammation in PF...
  24. ncbi Could exhaled ferritin and SOD be used as markers for lung cancer and prognosis prediction purposes?
    Giovanna E Carpagnano
    Institute of Respiratory Disease, Department of Medical and Occupational Sciences, University of Foggia, Foggia, Italy
    Eur J Clin Invest 42:478-86. 2012
    ..The aim of this study was to evaluate the clinical value and the prognostic power of exhaled ferritin and exhaled SOD in patients with lung cancer...
  25. ncbi Exhaled nitric oxide in a Taiwanese population: age and lung function as predicting factors
    Hsu Chung Liu
    Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan
    J Formos Med Assoc 108:772-7. 2009
    ..The present study investigated reference values and determinants of FE(NO) in a Taiwanese non-smoking, healthy adult population...
  26. ncbi Changes in exhaled nitric oxide levels after bronchial allergen challenge
    Maria Pedrosa
    Department of Allergy, Hospital La Paz Health Research Institute, IdiPAZ, Madrid, Spain
    Lung 190:209-14. 2012
    ..The aim of this study was to assess airway inflammation with FeNO measurements during bronchial allergen challenge (BAC), and to determine the diagnostic performance of FeNO changes...
  27. ncbi The analysis of volatile organic compounds biomarkers for lung cancer in exhaled breath, tissues and cell lines
    Yishan Wang
    Biosensor National Special Lab, Key Lab for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China
    Cancer Biomark 11:129-37. 2012
    ..Volatile organic compounds (VOCs) biomarkers in breath provide a novel, noninvasive and quick approach to diagnosis lung cancer. The aim of the proposed study was to investigate the VOCs biomarkers in exhaled breath for lung cancer...
  28. ncbi Methodological aspects of exhaled breath condensate collection and analysis
    Philippe Rosias
    Department of Paediatrics, Orbis Medical Center, Sittard, The Netherlands
    J Breath Res 6:027102. 2012
    ..It may also serve as a methodological checklist for a more systematical approach of EBC research and development...
  29. ncbi Exhaled Interleukine-6 and 8-isoprostane in chronic obstructive pulmonary disease: effect of carbocysteine lysine salt monohydrate (SCMC-Lys)
    Giovanna E Carpagnano
    Institute of Respiratory Diseases, University of Medicine, Foggia, Italy
    Eur J Pharmacol 505:169-75. 2004
    ..Moreover, we showed an anti-inflammatory and antioxidant effect of short-term administration of SCMC-Lys in COPD, suggesting the importance of a further placebo-controlled study that should evaluate the effects of this drug...
  30. pmc Malondialdehyde in exhaled breath condensate as a marker of oxidative stress in different pulmonary diseases
    M L Bartoli
    Cardiothoracic and Vascular Department, University of Pisa, Ospedale di Cisanello, Via Paradisa 2, 56124 Pisa, Italy
    Mediators Inflamm 2011:891752. 2011
    ..Exhaled breath condensate (EBC) collection is a noninvasive method to investigate pulmonary oxidative stress biomarkers such as malondialdehyde (MDA)...
  31. ncbi Exhaled nitric oxide: the missing link between asthma and obesity?
    Karin M De Winter-de Groot
    J Allergy Clin Immunol 115:419-20. 2005
  32. ncbi Analyses of mouse breath with ion mobility spectrometry: a feasibility study
    Wolfgang Vautz
    ISAS Institute for Analytical Sciences, Department of Metabolomics, Bunsen Kirchhoff Strasse 11, 44139 Dortmund, Germany
    J Appl Physiol (1985) 108:697-704. 2010
    ..Nevertheless, the results of the study demonstrate that the method is capable of rapid analyses of the breath of mice, thus significantly increasing the information obtained from each particular animal experiment...
  33. ncbi Study on the initial velocity distribution of exhaled air from coughing and speaking
    Soon Bark Kwon
    Subway IAQ Research Corps, Korea Railroad Research Institute, Gyeonggi Do, South Korea
    Chemosphere 87:1260-4. 2012
    ..Also, the linear relation between the tested subject's height and their coughing and speaking velocity was shown in this study...
  34. ncbi Exhaled air molecular profiling in relation to inflammatory subtype and activity in COPD
    N Fens
    Depts of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, PO Box 22700, NL 1100 DE Amsterdam, The Netherlands
    Eur Respir J 38:1301-9. 2011
    ..This suggests that breath analysis may be used for assessment and monitoring of airway inflammation in COPD...
  35. pmc Features of severe asthma in school-age children: Atopy and increased exhaled nitric oxide
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Allergy Clin Immunol 118:1218-25. 2006
    ..Children with severe asthma have persistent symptoms despite treatment with inhaled corticosteroids (ICSs). The differentiating features of severe asthma in children are poorly defined...
  36. ncbi A profile of volatile organic compounds in breath discriminates COPD patients from controls
    J J B N Van Berkel
    Department of Health Risk Analysis and Toxicology, Faculty of Health, Medicine and Life Sciences, Research Institute NUTRIM, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Respir Med 104:557-63. 2010
    ..We recently developed a methodological approach able to identify profiles of VOCs in breath unique for patient groups. Here we applied this recently developed methodology regarding diagnosis of COPD patients...
  37. pmc Exhaled breath condensate: an overview
    John Hunt
    Department of Pediatrics Pulmonology, Allergy and Immunology, Box 800386, University of Virginia, Charlottesville, VA 22908, USA
    Immunol Allergy Clin North Am 27:587-96; v. 2007
    ..Conscientious assay technique will likely find in EBC any substance of substantially high enough concentration in the airway lining fluid...
  38. ncbi An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD
    Silvano Dragonieri
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    Lung Cancer 64:166-70. 2009
    ..We hypothesized that an electronic nose can discriminate patients with lung cancer from COPD patients and healthy controls by analyzing the VOC-profile in exhaled breath...
  39. ncbi Non-invasive metabolomic analysis of breath using differential mobility spectrometry in patients with chronic obstructive pulmonary disease and healthy smokers
    Maria Basanta
    Respiratory Research Group, Manchester Academic Health Science Centre, University of Manchester, Wythenshawe Hospital, Manchester, UK
    Analyst 135:315-20. 2010
    ..82). Partial least squares discriminant analysis using the full DMS chromatograms also gave excellent discrimination between groups (alpha = 19% and beta = 12.4%)...
  40. ncbi Airborne infectious disease and the suppression of pulmonary bioaerosols
    Jennifer Fiegel
    Division of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
    Drug Discov Today 11:51-7. 2006
    ..We also discuss these implications in relation to airborne infectious disease control...
  41. pmc Determinants of exhaled breath condensate pH in a large population with asthma
    Lei Liu
    Department of Public Health Sciences at University of Virginia, Charlottesville, VA, USA
    Chest 139:328-36. 2011
    ..We hypothesized that patients with severe asthma would have low EBC pH and that there would be an asthma subpopulation of patients with characteristically low values...
  42. pmc A schlieren optical study of the human cough with and without wearing masks for aerosol infection control
    Julian W Tang
    Department of Laboratory Medicine, National University of Singapore, Singapore
    J R Soc Interface 6:S727-36. 2009
    ....
  43. pmc Exhaled nitric oxide, susceptibility and new-onset asthma in the Children's Health Study
    T M Bastain
    Dept of Preventive Medicine, Keck School of Medicine, 1540 Alcazar Street, CHP 236, Los Angeles, CA 90033, USA
    Eur Respir J 37:523-31. 2011
    ..Our results indicate that children with elevated F(eNO) are at increased risk for new-onset asthma, especially if they have no parental history of asthma...
  44. ncbi Exhaled nitric oxide and nitric oxide synthase expression in Hodgkin's disease
    G Guida
    Department of Biomedical Sciences and Human Oncology, University of Torino, Torino, Italy
    Int J Immunopathol Pharmacol 22:1027-34. 2009
    ..4-17.8, p=0.011). In conclusion, high FENO and NOS expression in lymph-nodes indicate that NO is a component of the inflammatory network of HD. FENO may be proposed for the assessment and follow up of bulky mediastinal HD patients...
  45. ncbi Screening for emphysema via exhaled volatile organic compounds
    S M Cristescu
    Life Science Trace Gas Facility, Molecular and Laser Physics, Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands
    J Breath Res 5:046009. 2011
    ..646 (95% CI 0.562-0.730) and 0.671 (95% CI 0.524-0.710), respectively. In the screening setting, exhaled VOCs measured by PTR-MS constitute weak markers for emphysema, pulmonary obstruction and impaired diffusion capacity...
  46. ncbi Non-invasive phenotyping using exhaled volatile organic compounds in asthma
    Baharudin Ibrahim
    Respiratory Research Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    Thorax 66:804-9. 2011
    ..The authors aimed to identify specific patterns of breath VOCs in patients with asthma and in clinically relevant disease phenotypes...
  47. ncbi The application of statistical methods using VOCs to identify patients with lung cancer
    Agnieszka Ulanowska
    Chair of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin Street 7, 87 100 Torun, Poland
    J Breath Res 5:046008. 2011
    ..DA revealed that in order to recognize healthy volunteers with different smoking habits by breath analysis, butyrolactone, carbon disulfide and dimethyl sulfide have to be considered...
  48. pmc Asthma outcomes: biomarkers
    Stanley J Szefler
    National Jewish Health, Denver, Colorado, USA
    J Allergy Clin Immunol 129:S9-23. 2012
    ..Measurement of biomarkers has been incorporated within clinical research studies of asthma to characterize the population and associate the disease with environmental and therapeutic effects...
  49. pmc Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children
    Daniel J Jackson
    Department of Pediatrics, University of Wisconsin Madison, Madison, Wis, USA
    J Allergy Clin Immunol 124:949-53. 2009
    ..Factors affecting fractional exhaled nitric oxide (FeNO) in early childhood are incompletely understood...
  50. ncbi Increased exhaled nitric oxide predicts new-onset rhinitis and persistent rhinitis in adolescents without allergic symptoms
    A Malinovschi
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Clin Exp Allergy 42:433-40. 2012
    ..We have previously suggested that elevated FE(NO) levels in the absence of asthma symptoms may be a sign of 'early asthma'. In the present study, we hypothesize that elevated exhaled NO levels may also precede rhinitis symptoms...
  51. ncbi Increased heme catabolism in critically ill patients: correlation among exhaled carbon monoxide, arterial carboxyhemoglobin, and serum bilirubin IXalpha concentrations
    Hiroshi Morimatsu
    Department of Anesthesiology and Resuscitology, Okayama University Medical School, Okayama 700 8558, Japan
    Am J Physiol Lung Cell Mol Physiol 290:L114-9. 2006
    ..These findings suggest there is an increased heme breakdown in critically ill patients and that exhaled CO concentration, arterial CO-Hb, and serum total BR concentrations may be useful markers in critically ill conditions...
  52. pmc Atopic sensitization to common allergens without symptoms or signs of airway disorders does not increase exhaled nitric oxide
    Annamari Rouhos
    Division of Respiratory Diseases, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Clin Respir J 2:141-8. 2008
    ..It is, however, unclear whether sensitization to common allergens per se- as verified with positive skin prick tests--affects FENO in healthy individuals...
  53. pmc Human brain activation during phonation and exhalation: common volitional control for two upper airway functions
    Torrey M J Loucks
    Laryngeal and Speech Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA
    Neuroimage 36:131-43. 2007
    ..phonation, we used event-related fMRI to contrast brain activity during phonation with activity during prolonged exhalation in healthy adults. Both whole-brain analyses and region of interest comparisons were conducted...
  54. ncbi Passive smoking is a major determinant of exhaled nitric oxide levels in allergic asthmatic children
    Y Laoudi
    Centre de l Asthme et des Allergies, Hopitaux de Paris, Université Pierre et Marie Curie Paris, France
    Allergy 65:491-7. 2010
    ..In children, the evidence in favour of an impact of passive smoking (PS) on FeNO values is controversial. The aim of this study was to evaluate the impact of chronic PS on FeNO in allergic asthmatic children...
  55. ncbi Nitrite in exhaled breath condensate as a marker of nitrossative stress in the airways of patients with asthma, COPD, and idiopathic pulmonary fibrosis
    Vladimír Rihák
    Department of Respiratory Diseases, Regional Thomas Bata Hospital, Havlíckovo nábrezí, Zlin, Czech Republic
    J Clin Lab Anal 24:317-22. 2010
    ....
  56. pmc Learning to breathe: control of the inspiratory-expiratory phase transition shifts from sensory- to central-dominated during postnatal development in rats
    Mathias Dutschmann
    Institute for Membrane and Systems Biology, University of Leeds, Leeds LS2 9JT, UK
    J Physiol 587:4931-48. 2009
    ..The anticipatory IOS may imply a hitherto undescribed form of pattern learning and recall in convergent sensory and central synaptic pathways that mediate IOS...
  57. ncbi Portable exhaled nitric oxide measurement: Comparison with the "gold standard" technique
    Daniel Menzies
    Asthma and Allergy Research Group, Dundee, Scotland, UK
    Chest 131:410-4. 2007
    ..A portable nitric oxide analyzer (MINO; Aerocrine AB; Smidesvägen, Sweden) has been developed, but few data exist comparing this device with established, larger laboratory-based analyzers (NIOX; Aerocrine AB)...
  58. ncbi Long-term oral n-acetylcysteine reduces exhaled hydrogen peroxide in stable COPD
    Fernando De Benedetto
    Department of Pneumology, Ospedale San Camillo de Lellis, Via Carlo Forlanini, 50 66100 Chieti, Italy
    Pulm Pharmacol Ther 18:41-7. 2005
    ..28+/-0.61 microM). No significant decrease in H(2)O(2) of group B was found at any time point. We conclude that oral NAC 600 mg b.i.d. for 2 months rapidly reduces the oxidant burden in airways of stable COPD patients...
  59. ncbi Passive and active smoking and exhaled nitric oxide levels according to asthma and atopy in adults
    Rachel Nadif
    INSERM, CESP Centre for research in Epidemiology and Population Health, Respiratory and Environmental Epidemiology Team U1018, Villejuif, France
    Ann Allergy Asthma Immunol 104:385-93. 2010
    ..No data are available regarding the utility of fractional exhaled nitric oxide (FeNO) level in guiding therapy in smoking asthmatic patients. Identification of the effect of smoking in a large sample is needed...
  60. ncbi Oxidative stress in expired breath condensate of patients with COPD
    Konstantinos Kostikas
    Pneumonology and Clinical Research Department, Athens Army General Hospital, Athens, Greece
    Chest 124:1373-80. 2003
    ....
  61. ncbi Decreased fraction of exhaled nitric oxide in obese subjects with asthma symptoms: data from the population study INTERGENE/ADONIX
    Christina M Berg
    Department of Food and Nutrition, and Sport Science, University of Gothenburg, Box 300, SE 405 30 Gothenburg, Sweden
    Chest 139:1109-16. 2011
    ..The aim of this study was to examine if obese subjects with asthma symptoms have a different phenotype of asthma than nonobese subjects as indicated by Feno...
  62. pmc Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients
    Rembert Koczulla
    Department of Pulmonology, Leiden University Medical Center, The Netherlands
    Respir Res 10:78. 2009
    ..Analysis of exhaled breath condensate (EBC) is a non-invasive method for studying the acidity (pH) of airway secretions in patients with inflammatory lung diseases...
  63. ncbi A simple technique to characterize proximal and peripheral nitric oxide exchange using constant flow exhalations and an axial diffusion model
    Peter Condorelli
    Department of Biomedical Engineering, 3120 Natural Sciences II, University of California, Irvine, Irvine, CA 92697 2715, USA
    J Appl Physiol (1985) 102:417-25. 2007
    ..Solution of the diffusion equation for the TMAD for exhalation flows >100 ml/s can be reduced to the same linear relationship between the NO elimination rate and the flow; ..
  64. ncbi The mechanism of breath aerosol formation
    Graham Richard Johnson
    International Laboratory for Air Quality and Health, Queensland University of Technology, Brisbane, Australia
    J Aerosol Med Pulm Drug Deliv 22:229-37. 2009
    ..That mechanism is not consistent with a high degree of asymmetry between aerosol production during inhalation and exhalation. The objective was to investigate production symmetry during breathing.
  65. ncbi Epithelial lining fluid solute concentrations in chronic obstructive lung disease patients and normal subjects
    Richard M Effros
    Los Angeles Biomedical Research Institute at Harbor University of California Los Angeles Medical Center, Torrance, 90505, USA
    J Appl Physiol (1985) 99:1286-92. 2005
    ..Dilutional and salivary markers are essential for interpretation of EBC studies...
  66. ncbi Feasibility of a new method to collect exhaled breath condensate in pre-school children
    Philippe P R Rosias
    Department of Paediatrics, Orbis Medical Center, Sittard, The Netherlands
    Pediatr Allergy Immunol 21:e235-44. 2010
    ..This new method may help to assess - non-invasively - cytokine profiles in asthmatic and non-asthmatic pre-school children...
  67. ncbi Exhaled breath condensate and airway inflammation
    Frank Hoffmeyer
    BGFA, Research Institute of Occupational Medicine, German Social Accident Insurance, Ruhr University Bochum, Germany
    Curr Opin Allergy Clin Immunol 9:16-22. 2009
    ..This article reviews recent data concerning the ability of EBC markers to reflect alterations in asthma and chronic obstructive pulmonary disease or environment and occupation-induced changes...
  68. ncbi Multicentre trial evaluating alveolar NO fraction as a marker of asthma control and severity
    B Mahut
    Cabinet La Berma, Antony, France
    Allergy 65:636-44. 2010
    ..The aim of this multicentre prospective study was to assess whether alveolar NO fraction and FE(NO) could be associated with the level of asthma control and severity both at the time of measurement and in the subsequent 3 months...
  69. ncbi Exhaled markers of inflammatory lung diseases: ready for routine monitoring?
    Sergei A Kharitonov
    National Heart and Lung Institute, Imperial College, Royal Brompton Hospital, London, UK
    Swiss Med Wkly 134:175-92. 2004
    ..The article reviews whether current noninvasive measurements of exhaled gases, such as nitric oxide (NO), hydrocarbons, inflammatory markers exhaled breath condensate (EBC) are ready for routine use in clinical practice...
  70. ncbi Classification of breast cancer precursors through exhaled breath
    Gregory Shuster
    The Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion Israel Institute of Technology, 32000 Haifa, Israel
    Breast Cancer Res Treat 126:791-6. 2011
    ..Breath testing with a NA-NOSE holds future potential as a cost-effective, fast, and reliable diagnostic test for breast cancer risk factors and precursors, with possible future potential as screening method...
  71. ncbi Observing and quantifying airflows in the infection control of aerosol- and airborne-transmitted diseases: an overview of approaches
    J W Tang
    Department of Laboratory Medicine, National University Hospital, Singapore, Singapore
    J Hosp Infect 77:213-22. 2011
    ..This article outlines each of these techniques in a non-technical manner, suitable for a clinical readership without specialist airflow or engineering knowledge...
  72. ncbi Exhalation of respiratory viruses by breathing, coughing, and talking
    Sacha Stelzer-Braid
    Faculty of Science, School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, NSW, Australia
    J Med Virol 81:1674-9. 2009
    ..In the subset of exhaled samples from 10 subjects examined by culture, infective rhinovirus was detected in 2. These data provide further evidence that breathing may be a source of respirable particles carrying infectious virus...
  73. ncbi Metabolomics applied to exhaled breath condensate in childhood asthma
    Silvia Carraro
    Department of Pediatrics, University of Padova, 35128 Padova, Italy
    Am J Respir Crit Care Med 175:986-90. 2007
    ..Metabolomic analysis provides biochemical profiles of low-molecular-weight endogenous metabolites in biological fluids...
  74. ncbi 8-Isoprostane, a marker of oxidative stress, is increased in exhaled breath condensate of patients with obstructive sleep apnea after night and is reduced by continuous positive airway pressure therapy
    Giovanna E Carpagnano
    Institute of Respiratory Diseases, University of Bari, Bari, Italy
    Chest 124:1386-92. 2003
    ..Obstructive sleep apnea (OSA) is characterized by recurrent apnea during sleep that may compromise oxidative balance. Oxidative stress is increased in the blood and in the airways of OSA patients...
  75. pmc Clinical patterns in asthma based on proximal and distal airway nitric oxide categories
    James L Puckett
    Department of Biomedical Engineering, 2420 Engineering Tower, University of California, Irvine, Irvine, CA 92697, USA
    Respir Res 11:47. 2010
    ..We hypothesized that J'awNO and CANO are selectively elevated in asthmatics, permitting identification of four inflammatory categories with distinct clinical features...
  76. ncbi Exhaled air dispersion during oxygen delivery via a simple oxygen mask
    David S Hui
    Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, 30 32 Ngan Shing St, Shatin, New Territories, Hong Kong, People s Republic of China
    Chest 132:540-6. 2007
    ..We studied the dispersion of exhaled air through a simple oxygen mask applied to a human patient simulator (HPS) during the delivery of different oxygen flow in a room free of air currents...
  77. ncbi The relationship of exhaled nitric oxide to airway inflammation and responsiveness in children
    Paul S Thomas
    Faculty of Medicine, University of New South Wales, Randwick, New South Wales, Australia
    J Asthma 42:291-5. 2005
    ..eNO appears to be a useful indicator of atopy and airway inflammation, but in this population it was not closely related to airway hyperresponsiveness...
  78. ncbi Human skin keratins are the major proteins in exhaled breath condensate
    H J Hoffmann
    Dept of Respiratory Diseases, Aarhus University Hospital, Denmark
    Eur Respir J 31:380-4. 2008
    ..Filtration of inspired air did not remove contaminating keratin. In conclusion, skin keratin in exhaled breath condensate derives from ambient air and not from the respiratory tract...
  79. ncbi Enhanced exhalation of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in patients with COPD exacerbation: a prospective study
    S Kwiatkowska
    Ward of Clinical Pneumology, Medical University of Lodz, Poland
    Respiration 84:231-41. 2012
    ..However, no study so far has addressed their value as noninvasive biomarkers of airways inflammation...
  80. ncbi [Limitations of the technique to determine hydrogen peroxide levels in exhaled breath condensate from patients with adult respiratory distress syndrome]
    A Bruhn
    Departamento de Enfermedades Respiratorias, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile
    Arch Bronconeumol 41:542-6. 2005
    ..In an attempt to explain this variability, the aim of the present study was to assess the possible limitations of the most commonly used technique for analyzing H2O2 in breath condensate...
  81. ncbi Volatile organic compounds in the exhaled breath of young patients with cystic fibrosis
    M Barker
    Dept of Paediatrics, University of Technology RWTH Medical Center, Aachen, Germany
    Eur Respir J 27:929-36. 2006
    ..It was concluded that chemical breath analysis for volatile organic compounds is feasible and may hold potential for the noninvasive diagnosis and follow-up of inflammatory processes in cystic fibrosis lung disease...
  82. ncbi Influence of expiratory loading and hyperinflation on cardiac output during exercise
    Kristy N Stark-Leyva
    Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Appl Physiol (1985) 96:1920-7. 2004
    ....
  83. ncbi Discrimination between COPD patients with and without alpha 1-antitrypsin deficiency using an electronic nose
    Akira D M Hattesohl
    Department for Internal Medicine, Division for Pulmonary Diseases, Philipps University Marburg, Marburg, Germany
    Respirology 16:1258-64. 2011
    ..To compare the volatile organic compound patterns of patients with COPD with and without alpha 1-antitrypsin (AAT) deficiency using electronic nose technology...
  84. ncbi On the interaction between respiratory compartments during passive expiration in ARDS patients
    Gian Luca Chelucci
    Unit of Respiratory Pathophysiology, Department of Critical Care Medicine and Surgery, University of Florence, V le Morgagni 85, I 50134, Italy
    Respir Physiol Neurobiol 145:53-63. 2005
    ..The volume-time profile of the second compartment was found to increase at the beginning of expiration, and, then, progressively decayed towards zero, showing a maximum, although the overall curve decreased throughout expiration...
  85. ncbi Determination of in vivo carbon monoxide production in laboratory animals via exhaled air
    Ryan A Dercho
    Department of Pharmacology and Toxicology, Queen s University, Kingston, ON, Canada K7L 3N6
    J Pharmacol Toxicol Methods 54:288-95. 2006
    ..Here, we describe a modified flow-through method for the collection and quantitation of CO from small laboratory animals...
  86. ncbi Nepsilon-(carboxymethyl)lysine, a major advanced glycation end product in exhaled breath condensate as a biomarker of small airway involvement in asthma
    Yoshihiro Tochino
    Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, Osaka, Japan
    J Asthma 44:861-6. 2007
    ..Therefore, CML level in EBC is a non-invasive biomarker for evaluating small airway involvements in asthma...
  87. ncbi Secondary electrospray ionization-mass spectrometry: breath study on a control group
    P Martínez-Lozano
    National Research Council Institute for Biomedical Technologies CNR ITB, Via Fratelli Cervi 93, 20090 Segrate Mi, Italy
    J Breath Res 5:016002. 2011
    ..This is consistent with previous NMR-based studies indicating the existence of stable individual metabolic phenotypes...
  88. ncbi Exhaled nitric oxide measurement in patients affected by nasal polyposis
    Jacopo Galli
    ENT Institute, Catholic University of Sacred Heart Rome, Rome, Italy
    Otolaryngol Head Neck Surg 147:351-6. 2012
    ....
  89. ncbi External validation of exhaled breath profiling using an electronic nose in the discrimination of asthma with fixed airways obstruction and chronic obstructive pulmonary disease
    N Fens
    Department of Respiratory Medicine, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Allergy 41:1371-8. 2011
    ..Fixed airflow limitation can be found both in asthma and chronic obstructive pulmonary disease (COPD), posing a day-to-day diagnostic challenge...
  90. ncbi Machine learning methods on exhaled volatile organic compounds for distinguishing COPD patients from healthy controls
    Chris O Phillips
    Welsh Centre for Printing and Coating, College of Engineering, Swansea University, Singleton Park, Swansea SA2 8PP, UK
    J Breath Res 6:036003. 2012
    ..Applying different analytical methods to the largest group of subjects so far, suggests VOC analysis holds promise for diagnosing COPD but smoking status needs to be balanced...
  91. ncbi Organic metabolites in exhaled human breath--a multivariate approach for identification of biomarkers in lung disorders
    Elvira M Gaspar
    Chemistry Department, CQFB REQUIMTE, Faculty of Sciences and Technology, New University of Lisbon, Quinta da Torre, 2825 114 Monte da Caparica, Portugal
    J Chromatogr A 1216:2749-56. 2009
    ..04 to 8.0ppb. These findings show a high potential for establishment of laboratorial screening methods. Validation studies in a larger number of patients are being done...
  92. ncbi Hydrogen peroxide in exhaled breath condensate in patients with asthma: a promising biomarker?
    Yue Teng
    Department of Respiratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
    Chest 140:108-16. 2011
    ..The purpose of this study was to explore whether EBC H(2)O(2) is elevated in people with asthma and whether it reflects disease severity and disease control or responds to corticosteroid treatment...
  93. ncbi Validation of the Better Care® system to detect ineffective efforts during expiration in mechanically ventilated patients: a pilot study
    Lluis Blanch
    Critical Care Center, Hospital de Sabadell, Corporació Sanitària Universitària Parc Taulí, Universitat Autonoma de Barcelona, Parc Taulí 1, 08208 Sabadell, Spain
    Intensive Care Med 38:772-80. 2012
    ..The goal of this study is to validate mathematical algorithms that automatically detect IEE in a computerized (Better Care®) system that obtains and processes data from intensive care unit (ICU) ventilators in real time...
  94. doi Proteomics of exhaled breath condensate: a realistic approach in children with asthma?
    E Dompeling
    Clin Exp Allergy 41:299-301. 2011
  95. ncbi Exhaled breath condensate nitrates, but not nitrites or FENO, relate to asthma control
    Andrei Malinovschi
    Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden
    Respir Med 105:1007-13. 2011
    ..Our aim was to investigate the relationships between asthma control and the above-named biomarkers of airways inflammation...
  96. ncbi Consistently high levels of exhaled nitric oxide in children with asthma
    Tadakazu Sakai
    Department of Pediatrics, Tokai University School of Medicine, Shimokasuya, Isehara, Kanagawa, Japan
    Pediatr Int 52:801-5. 2010
    ..The purpose of the current study was to evaluate the reliability of eNO levels between a long interval and other lung functions in normal and asthmatic children...
  97. ncbi Breath acetone concentration; biological variability and the influence of diet
    Patrik Spanel
    J Heyrovsky Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Dolejskova 3, 182 23, Prague 8, Czech Republic
    Physiol Meas 32:N23-31. 2011
    ..This places an uncertainty in the use of breath acetone alone to monitor blood glucose and glycaemic control, except and unless the individual acts as their own control and is cognizant of the need for dietary control...
  98. ncbi Exhaled air dispersion and removal is influenced by isolation room size and ventilation settings during oxygen delivery via nasal cannula
    David S Hui
    Stanley Ho Center for Emerging Infectious Diseases, Department Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
    Respirology 16:1005-13. 2011
    ..We compared the exhaled air dispersion distances during oxygen delivery via nasal cannula to a human-patient simulator (HPS) in two different isolation rooms...
  99. pmc Exhaled breath condensate pH as a biomarker of COPD severity in ex-smokers
    Andriana I Papaioannou
    Respiratory Medicine Department, University of Thessaly Medical School, Larissa, Greece
    Respir Res 12:67. 2011
    ..The possible role of EBC pH in COPD needs to be further evaluated in longitudinal studies...
  100. ncbi Methodology validation, intra-subject reproducibility and stability of exhaled volatile organic compounds
    M Basanta
    Respiratory Research Group, Faculty of Medical and Human Sciences, University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester, Manchester, UK
    J Breath Res 6:026002. 2012
    ..These parameters will require investigation in studies of potential breath biomarkers, and must be standardized if tests are to become clinically useful...
  101. ncbi Reliability of a new hand-held device for the measurement of exhaled nitric oxide
    B Khalili
    Louisiana State University Health Sciences Center Allergy and Immunology, Shreveport, LA 71103, USA
    Allergy 62:1171-4. 2007
    ..The aim of this study was to compare the performance of a new hand-held FeNO measuring device (NIOX MINO) to the current clinical standard - the chemiluminescence FeNO analyzer (NIOX)...

Research Grants62

  1. Immune modulators of inflammation in servere COPD
    Farrah Kheradmand; Fiscal Year: 2010
    ..of lung matrix, especially elastin, resulting in loss of elastic recoil, dynamic airway collapse during exhalation, air trapping and lung hyperinflation...
  2. Mechanical Airway Support Device to Treat Obstructive Sleep Disordered Breathing
    Philip M Wong; Fiscal Year: 2013
    ..The machine stores kinetic energy from exhalation against resistance as potential energy, and converts this back to kinetic energy and continued pressure during ..
  3. Time-resolved measurements of breath hydrogen sulfide
    STEVEN M MASSICK; Fiscal Year: 2010
    ..NICE-OHMS should be useful for breath analysis. It works well with small gas samples (~50 std. cc per exhalation) and has fast time response. Fully engineered analyzers will be about the size of a desktop computer...
  4. Respiratory Mechanics in Lung Disease and Surgery
    Stephen H Loring; Fiscal Year: 2010
    ..Mechanical ventilator settings that cause PL values to be either too high at end-inflation or too low at end-exhalation (ee) can result in ventilator-induced lung injury (VILI), even when tidal volume is limited...
  5. Reducing Dynamic Hyperinflation through Breathing Retraining
    Eileen G Collins; Fiscal Year: 2013
    ..retraining plus exercise group will also receive auditory feedback to decrease respiratory rate and prolong exhalation. The goal of breathing retraining is to reduce exercise- induced dynamic hyperinflation...
  6. Development of Integrated Environmental Carcinogen Exposure Monitor and Metabolic
    STEPHEN G SO; Fiscal Year: 2010
    ..1) Benzene (C6H6) for real time exposure monitoring and post-exposure studies through breath analysis of Benzene exhalation and 2) hydrogen peroxide (H2O2) for breath analysis of oxidative stress...
  7. Acoustic and Respiratory System Correlates of Pausing
    Janet Slifka; Fiscal Year: 2009
    ..In general, a speaker may inhale at a pause or pause in the course of an exhalation (within-breath). Both types are highly frequent in normal and disordered communication...
  8. ANIMAL MODELS OF COLD AIR-INDUCED AIRWAY DISEASE
    Michael Davis; Fiscal Year: 2004
    ..Unidirectional airflow prevents the reclamation of water during exhalation, and thus, may exaggerate the airway drying during hyperpnea...
  9. PERFORMANCE OF SURGICAL MASKS
    Klaus Willeke; Fiscal Year: 1993
    ..will be evaluated on masks that have been wetted, as may occur from liquid splashing or liquid adsorption during exhalation of warm, humid air. Edge leakage will be measured relative to filter penetration...
  10. RESPIRATOR EFFICACY VERSUS TUBERCULOSIS AEROSOLS
    John Koerner; Fiscal Year: 2000
    ..protection with respect to mycobacterium aerosols and using a method that incorporates inhalation and exhalation into the respirator performance test; and 5) to determine what, if any, differences in respirator performance ..
  11. VENTING FOR REDUCTION OF HYPERINFLATION IN EMPHYSEMA
    Joel Cooper; Fiscal Year: 2005
    ..This will allow the lungs to deflate more completely on exhalation, relieving breathlessness and increasing the patients' tolerance for exertion...
  12. T5000 Diagnostic System in Ferret Model of Influenza
    Frederick Koster; Fiscal Year: 2009
    ..and associated influenza surveillance kit for sensitivity, specificity, early diagnosis capability, and aerosol exhalation in the ferret model of H3N2 and H5N1 influenza infection...
  13. AEROSOL PENETRATION BEHAVIOR OF RESPIRATOR VALVES
    Lisa Brosseau; Fiscal Year: 1993
    ..This research will examine aerosol penetration and leak flow through exhalation and inhalation valves from negative pressure air-purifying respirators...
  14. A SERVO-CONTROLLED VENTILATOR FOR INFANTS AND CHILDREN
    Charles Richardson; Fiscal Year: 1993
    ..The conventional approach for infants uses a valve placed at the end of several feet of exhalation tubing...
  15. APD to Measure the Resistance of the Respiratory System
    JAFAR VOSSOUGHI; Fiscal Year: 2004
    ..Normal values of average respiratory resistance have been determined. Resistances in the inhalation and exhalation directions have also been obtained...
  16. RECYCLE OF 3HE FOR HIGH-RESOLUTION LUNG IMAGING
    MICHAEL IZENSON; Fiscal Year: 1999
    ..The innovation is a cryogenic gas separation system that extracts and purifies the 3He from a patient's exhalation stream and saves it for re-polarization3 and reuse in other patients...
  17. RECYCLE OF 129XE FOR HIGH-RESOLUTION LUNG IMAGING
    MICHAEL IZENSON; Fiscal Year: 2000
    ..The innovation is a cryogenic gas separation system that extracts and purifies the 129Xe from a patient's exhalation stream and saves it for re- polarization and reuse in other patients...
  18. Binder Free Diaphragm Pacing Stimulation and Airway Clearance Assistance
    Anthony Ignagni; Fiscal Year: 2006
    ..which would be done through the natural cough mechanism of the body - inspiration followed by a forceful exhalation. Upon successful design and bench testing of the system for this phase I project we will supplement our ..
  19. SERVO-CONTROLLED VENTILATOR FOR INFANTS AND CHILDREN
    Charles Richardson; Fiscal Year: 1991
    ..The conventional approach uses a valve placed at the end of several feet of exhalation tubing...
  20. RECYCLE OF 3HE FOR HIGH RESOLUTION LUNG IMAGING
    MICHAEL IZENSON; Fiscal Year: 2002
    ..The innovation is a cryogenic gas separation system that extracts and purifies the 3He from a patient's exhalation stream and saves it for re-polarization and reuse in other patients...
  21. RESPIRATORY STRESS AND OCCUPATIONAL RESPIRATOR WEAR
    Arthur Johnson; Fiscal Year: 1980
    ..Pulmonary function data, minute volume, respiratory quotient, oxygen uptake, airways resistance, and exhalation time for exercising subjects have been obtained and will be analyzed to determine if correlations exist.
  22. The Effect of Pulmonary Interstitial Edema on Gas Exchange
    G Prisk; Fiscal Year: 2009
    ..3) Define and quantify the relationship between alterations in the heterogeneity of pulmonary blood flow and lung water content using functional magnetic resonance imaging (fMRI) and X-ray techniques. ..
  23. Regional Hypoxic Pulmonary Vasoconstriction
    MICHAEL HLASTALA; Fiscal Year: 2006
    ..The results of the research will provide a more detailed understanding of the local and cellular mechanisms responsible for HPVR heterogeneity and mechanisms of development of disease in the mammalian lung. [unreadable] [unreadable]..
  24. Deposition of 0.5 to 2 Micron Aerosol in the Human Lung
    G Prisk; Fiscal Year: 2003
    ..5 to 1 micron). Such information will provide a much-improved basis for the assessment of exposure to small inhaled particles both in long duration spaceflight and on Earth. ..
  25. UNIQUE MECHANISM FOR REABSORPTION OF EDEMA IN THE LUNG
    Richard Effros; Fiscal Year: 2002
    ..The effects of lung injury caused by high vascular pressures, over distention of the lungs, acid aspiration and infections of the oleic acid will be investigated. ..
  26. Exhaled Nitric Oxide: Mechanisms and Limitations
    STEVEN CARL GEORGE; Fiscal Year: 2010
    ..Understanding the source of exhaled nitric oxide may significantly impact the clinical management of the disease. ..
  27. Dermatopharmacokinetics: In Vivo Analysis of Solvents
    Karla Thrall; Fiscal Year: 2005
    ..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..
  28. Caregivers of Prolonged Mechanical Ventilation: Mind-Body Interaction Model
    Jiyeon Choi; Fiscal Year: 2010
    ..Improving caregivers'emotional and physical health may also improve the delivery of care as well as quality of life for the care recipient. ..
  29. OPIOID DEPRESSION OF RESPIRATORY NEURONS
    PETER LALLEY; Fiscal Year: 2003
    ..It will also test a new method that may alleviate opioid-induced depression of respiration without affecting analgesia, and counteract respiratory depression by overdose of opioids. ..
  30. Phase II validation of 4-dimensional computed tomography derived ventilation for
    Thomas Guerrero; Fiscal Year: 2008
    ..Our new imaging method uses equipment already available in almost every radiation oncology clinic. This study seeks to validate our new ventilation imaging with the present standard method. [unreadable] [unreadable] [unreadable]..
  31. Functional Plasticity in Hypoglossal Motoneurons
    JACK FELDMAN; Fiscal Year: 2008
    ..If these pathologies are to be understood, the mechanisms controlling the output of respiratory motoneurons needs to be determined. ..
  32. NIREP: Non-rigid Image Registration Evaluation Project
    Gary Christensen; Fiscal Year: 2008
    ..3) Disseminate NIREP software and annotated reference databases to the research community. (4) Test performance of major non-rigid image registration algorithms contained in ITK and SPM using the NIREP software. ..
  33. Biomarkers of oxidative stress and inflammation in COPD
    William MacNee; Fiscal Year: 2005
    ..Such information will allow the identification of novel biomarkers and the fingerprints themselves may represent a mechanism to stratify COPD patients and allow the assessment of novel therapies. ..
  34. Oxidative stress and aortic valve disease
    Jordan Miller; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  35. EXPIRATORY MUSCLE ACTIVATION TO PRODUCE COUGH
    Anthony DiMarco; Fiscal Year: 2003
    ..Restoration of affective cough mechanism may allow patients with spinal cord injury to clear secretions more easily, reduce the incidence of respiratory complication and, ultimately, improve their life quality. ..
  36. Pediatric Severe Asthma: Role of Oxidant Stress and Alveolar Macrophage Function
    Anne Fitzpatrick; Fiscal Year: 2009
    ..This proposal will lay the foundation for further studies, and the mechanisms identified may ultimately be targeted in future interventional trials. ..
  37. Socioeconomic Status, Stress & Asthma Biological Markers
    Edith Chen; Fiscal Year: 2009
    ..The results from this project will allow us to begin developing models of how the larger social environment comes to affect a child's clinical course of asthma. ..
  38. Superoxide and Vascular Function in Heart Failure
    Jordan Miller; Fiscal Year: 2007
    ..Collectively, these studies will lend important insights into the role of oxidative stress and vascular function in HF. [unreadable] [unreadable] [unreadable]..
  39. Exhaled Biomarkers During Treatment of Rhinovirus
    John Hunt; Fiscal Year: 2004
    ..The project will be conducted at the University of Virginia, where expertise in the study of the common cold, airway chemistry, and exhaled biomarkers is extensive. ..
  40. Pediatric Asthma, Particulate Air Pollution and NO2
    RALPH DELFINO; Fiscal Year: 2006
    ..Long-term goals are to improve knowledge about the independent and combined adverse effects of particulate and gaseous air pollutants by examining acute exposures and responses using ambulatory monitoring methods. ..
  41. Regulation of the Cough Reflex
    Donald Bolser; Fiscal Year: 2006
    ..Furthermore, this project will test the proposed roles of medullary and spinal cellular elements that contribute to the generation and control of expiratory motor discharge during cough. ..
  42. Information Processing in Medical Imaging 2005
    Gary Christensen; Fiscal Year: 2005
    ..Women and Minorities are actively encouraged to attend and participate to the fullest extent in the IPMI through the Call for Papers, advertisements, and targeted personal contacts. ..
  43. Polysomnography in Homeopathic Remedy Effects
    Iris Bell; Fiscal Year: 2007
    ..This study will contribute to our long-range goal of understanding the neurophysiological and biopsychosocial mechanisms of classical homeopathic remedy treatment in patients with specific clinical conditions. ..
  44. Alcoholism, Sleep and the Brain
    IAN COLRAIN; Fiscal Year: 2007
    ..Hypothesis 4: Small amplitude, production rate and power of sleep electrophysiological variables in recently detoxified alcoholics will predict early relapse. ..
  45. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    PATRICE GUYENET; Fiscal Year: 2008
    ..The research will contribute to the basic physiological knowledge needed to understand how syrr pathetic tone is regulated in health and in diseases such as arrhythmias, hypertension and dysautonomias. ..
  46. ASTHMA AND EXPOSURE TO PEAKS IN PARTICULATE AIR POLLUT
    RALPH DELFINO; Fiscal Year: 2001
    ..This research is expected to have an impact on decisions regarding the protection of health in populations frequently exposed to higher particle excursions. ..
  47. Expired CO2/O2 Analysis to Diagnose Pulmonary Embolism
    JEFFREY KLINE; Fiscal Year: 2008
    ..This project will fund a clinical study designed to test the diagnostic accuracy of a hand- held breath device that detects the altered gas exchange physiology caused by PE in post-surgical and other patients at high risk for PE. ..
  48. Cortical Representational Plasticity of Oral Structures
    KENNETH CATANIA; Fiscal Year: 2003
    ..abstract_text> ..
  49. Inhaled Large Porous Particles for Treatment of MDR-TB
    David Edwards; Fiscal Year: 2006
    ..It represents a new paradigm for treating and limiting the spread (especially nosocomial transmission) of respiratory infectious diseases such as TB, severe acute respiratory syndrome (SARS), influenza, and small pox. ..
  50. Nitration immunology
    John Hunt; Fiscal Year: 2005
    ..This novel project may serve to elucidate an important link between innate and acquired immunity--identifying a highly novel mechanism for both inciting and regulating immune responses. ..
  51. ENZYMOLOGY OF ACETOTROPHIC METHANOGENESIS
    JAMES FERRY; Fiscal Year: 2003
    ..The results are expected to contribute not only to a deeper understanding of the acetate fermentation pathway, but more importantly to the broader field of anaerobic microbiology and beyond. ..
  52. Spinal Cord Stimulation to Restore Cough In Humans
    Anthony DiMarco; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  53. Environmental Exposures, NOS Genes, and Exhaled Nitric Oxide in Pediatric Asthma
    Adam Spanier; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  54. BIOLOGY AND CONTROL OF LYME DISEASE BORRELIA
    Alan Barbour; Fiscal Year: 2004
    ..burgdorferi, its transmission, and reservoir host immunize responses. The results may also have relevance for the control of other vector-bone zoonotic diseases and perhaps for development of novel methods for vaccine delivery. ..
  55. Facial and Dental Arch Growth Following Palatal Surgery
    William Williams; Fiscal Year: 2008
    ..A secondary part of the study will be a long-term follow-up of velopharyngeal function for speech. ..
  56. Development of Selective Nanoporous Sorbents for Radionuclide Decorporation
    Charles Timchalk; Fiscal Year: 2008
    ..abstract_text> ..
  57. Linking motor imagery to motor execution
    Sheng Li; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  58. Mixture Modeling: Pesticide Drug Interactions
    Charles Timchalk; Fiscal Year: 2009
    ..It is fully anticipated that this approach will facilitate the understanding of a variety of complex chemical interactions as it relates to the occupational health implications of working with insecticides. ..
  59. Towards a better understanding of work-aggravated asthma
    Catherine Lemiere; Fiscal Year: 2009
    ..The occurrence of asthma exacerbations will be recorded. The economic impact of WAA will be assessed in terms of work disability and use of health resources and compared with OA and asthma without OA not WAA. ..
  60. Pet Exposure, Allergy and Early Asthma in the Inner-City
    Matthew Perzanowski; Fiscal Year: 2005
    ..3) Determine whether pet allergen exposure in an inner-city community is associated with early predictors of allergic disease and asthma including persistent wheeze, doctor diagnosed eczema and asthma symptoms. ..