bronchoconstriction

Summary

Summary: Narrowing of the caliber of the BRONCHI, physiologically or as a result of pharmacological intervention.

Top Publications

  1. ncbi Effect of bronchoconstriction on airway remodeling in asthma
    Christopher L Grainge
    Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton, United Kingdom
    N Engl J Med 364:2006-15. 2011
  2. ncbi Serum vitamin D levels and exercise-induced bronchoconstriction in children with asthma
    I Chinellato
    Department of Paediatrics, University of Verona, Policlinico GB Rossi, Piazzale L Scuro, 37134 Verona, Italy
    Eur Respir J 37:1366-70. 2011
  3. ncbi Self-organized patchiness in asthma as a prelude to catastrophic shifts
    Jose G Venegas
    Massachusetts General Hospital, Department of Anesthesia and Critical Care, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nature 434:777-82. 2005
  4. pmc Influence of airway wall stiffness and parenchymal tethering on the dynamics of bronchoconstriction
    Mohammad Afzal Khan
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 299:L98-L108. 2010
  5. ncbi Parenchymal tethering, airway wall stiffness, and the dynamics of bronchoconstriction
    Jason H T Bates
    University of Vermont College of Medicine, Burlington, VT 05405 0075, USA
    J Appl Physiol (1985) 102:1912-20. 2007
  6. ncbi Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors
    John T Fisher
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    FASEB J 18:711-3. 2004
  7. ncbi Characterisation of guinea pig precision-cut lung slices: comparison with human tissues
    A R Ressmeyer
    Research Center Borstel, Borstel, Germany
    Eur Respir J 28:603-11. 2006
  8. ncbi Negative feedback between secretory and cytosolic phospholipase A2 and their opposing roles in ovalbumin-induced bronchoconstriction in rats
    Sarit Offer
    Institute of Biochemistry, Faculty of Agriculture, The Hebrew University, Rehovat, Jerusalem
    Am J Physiol Lung Cell Mol Physiol 288:L523-9. 2005
  9. ncbi Beyond the dogma: novel beta2-adrenoceptor signalling in the airways
    M A Giembycz
    Dept of Pharmacology and Therapeutics, Institute of Infection, Immunity and Inflammation, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
    Eur Respir J 27:1286-306. 2006
  10. ncbi Airway narrowing measured by spirometry and impulse oscillometry following room temperature and cold temperature exercise
    Tina M Evans
    Marywood University, 2300 Adams Ave, Scranton, PA 18509, USA
    Chest 128:2412-9. 2005

Detail Information

Publications300 found, 100 shown here

  1. ncbi Effect of bronchoconstriction on airway remodeling in asthma
    Christopher L Grainge
    Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton, United Kingdom
    N Engl J Med 364:2006-15. 2011
    ..In vitro studies indicate, however, that the compressive mechanical forces that arise during bronchoconstriction may induce remodeling independently of inflammation...
  2. ncbi Serum vitamin D levels and exercise-induced bronchoconstriction in children with asthma
    I Chinellato
    Department of Paediatrics, University of Verona, Policlinico GB Rossi, Piazzale L Scuro, 37134 Verona, Italy
    Eur Respir J 37:1366-70. 2011
    ..However, no study has examined the relationship between vitamin D levels and exercise-induced bronchoconstriction in asthmatic children...
  3. ncbi Self-organized patchiness in asthma as a prelude to catastrophic shifts
    Jose G Venegas
    Massachusetts General Hospital, Department of Anesthesia and Critical Care, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nature 434:777-82. 2005
    ..Here we present experimental evidence that bronchoconstriction leads to patchiness in lung ventilation, as well as a computational model that provides interpretation of ..
  4. pmc Influence of airway wall stiffness and parenchymal tethering on the dynamics of bronchoconstriction
    Mohammad Afzal Khan
    Asthma Research Group, Firestone Institute for Respiratory Health, St Joseph s Healthcare, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Am J Physiol Lung Cell Mol Physiol 299:L98-L108. 2010
    ..We conclude that airway and parenchymal remodeling as a result of protease activity can have varied effects on the loads opposing ASM shortening, with corresponding consequences for airway responsiveness...
  5. ncbi Parenchymal tethering, airway wall stiffness, and the dynamics of bronchoconstriction
    Jason H T Bates
    University of Vermont College of Medicine, Burlington, VT 05405 0075, USA
    J Appl Physiol (1985) 102:1912-20. 2007
    ..with the opposing loads of parenchymal tethering and airway wall stiffness to produce the dynamics of bronchoconstriction. We therefore developed a two-dimensional computational model of a dynamically narrowing airway embedded in ..
  6. ncbi Loss of vagally mediated bradycardia and bronchoconstriction in mice lacking M2 or M3 muscarinic acetylcholine receptors
    John T Fisher
    Department of Physiology, Queen s University, Kingston, Ontario, Canada K7L 3N6
    FASEB J 18:711-3. 2004
    ..the task of identifying the mAChR subtypes mediating cardiac slowing (bradycardia) and airway narrowing (bronchoconstriction) due to vagal innervation...
  7. ncbi Characterisation of guinea pig precision-cut lung slices: comparison with human tissues
    A R Ressmeyer
    Research Center Borstel, Borstel, Germany
    Eur Respir J 28:603-11. 2006
    ..The median effective concentrations (EC50, expressed as nM) for agonist-induced bronchoconstriction in GP and human PCLS, respectively, were: leukotriene D4 (1.8, 5.0); thromboxane (16, 1...
  8. ncbi Negative feedback between secretory and cytosolic phospholipase A2 and their opposing roles in ovalbumin-induced bronchoconstriction in rats
    Sarit Offer
    Institute of Biochemistry, Faculty of Agriculture, The Hebrew University, Rehovat, Jerusalem
    Am J Physiol Lung Cell Mol Physiol 288:L523-9. 2005
    ..To test this hypothesis, we examined the effect of a cell-impermeable extracellular sPLA2 inhibitor on bronchoconstriction and PLA2 expression in rats with ovalbumin (OVA)-induced asthma...
  9. ncbi Beyond the dogma: novel beta2-adrenoceptor signalling in the airways
    M A Giembycz
    Dept of Pharmacology and Therapeutics, Institute of Infection, Immunity and Inflammation, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
    Eur Respir J 27:1286-306. 2006
    ....
  10. ncbi Airway narrowing measured by spirometry and impulse oscillometry following room temperature and cold temperature exercise
    Tina M Evans
    Marywood University, 2300 Adams Ave, Scranton, PA 18509, USA
    Chest 128:2412-9. 2005
    ..airflow obstruction compared to spirometry after exercise challenges in the evaluation of exercise-induced bronchoconstriction (EIB) has not been fully appreciated...
  11. ncbi Effects of obesity on perceptual and mechanical responses to bronchoconstriction in asthma
    Athavudh Deesomchok
    Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    Am J Respir Crit Care Med 181:125-33. 2010
    The influence of obesity on the perception of respiratory discomfort during acute bronchoconstriction in asthma is unknown.
  12. ncbi Quantification of regional ventilation-perfusion ratios with PET
    Marcos F Vidal Melo
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    J Nucl Med 44:1982-91. 2003
    ..This study aims to present a PET-based method to estimate regional alveolar ventilation-to-perfusion ratios (V(A)/Q) predictive of arterial blood gases...
  13. ncbi The early allergic response in small airways of human precision-cut lung slices
    A Wohlsen
    Research Centre Borstel, Borstel, Germany
    Eur Respir J 21:1024-32. 2003
    ..response (EAR), the method of human precision-cut lung slices (PCLS) was developed and used to examine the bronchoconstriction elicited by passive sensitisation and allergen provocation...
  14. ncbi Role of acetylcholine and muscarinic receptors in serotonin-induced bronchoconstriction in the mouse
    Wolfgang Kummer
    Institute for Anatomy and Cell Biology, JLU, 35385 Giessen, Germany
    J Mol Neurosci 30:67-8. 2006
    ..that 5-HT evokes release of ACh from epithelial cells via OCTs and that this epithelial-derived ACh induces bronchoconstriction. We tested this hypothesis in a well-established model of videomorphometric analysis of bronchial diameter ..
  15. ncbi Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    Ronald L Sorkness
    Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    J Appl Physiol (1985) 104:394-403. 2008
    ..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component...
  16. ncbi Short-term smoke exposure attenuates ovalbumin-induced airway inflammation in allergic mice
    Barbro N Melgert
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    Am J Respir Cell Mol Biol 30:880-5. 2004
    ..Using whole body plethysmography, we found OVA-induced bronchoconstriction to be significantly inhibited in smoking OVA-mice as compared with nonsmoking OVA-mice (1 +/- 2% increase ..
  17. ncbi Dynamic hyperinflation and flow limitation during methacholine-induced bronchoconstriction in asthma
    C Tantucci
    Clinica di Semeiotica Medica, University of Ancona, Italy
    Eur Respir J 14:295-301. 1999
    ..NEP) method were monitored in 10 stable asthmatic subjects during methacholine-induced, progressive bronchoconstriction in seated position. Change in dyspnoea was scored using the Borg scale...
  18. ncbi Hyperpnea-induced bronchoconstriction and urinary CC16 levels in athletes
    Claire Bolger
    School of Medical Sciences, Department of Occupational Medicine, University of Aberdeen, Aberdeen, United Kingdom
    Med Sci Sports Exerc 43:1207-13. 2011
    Exercise-induced bronchoconstriction (EIB) is a common condition in both individuals with asthma and otherwise healthy elite athletes...
  19. pmc Inflammatory basis of exercise-induced bronchoconstriction
    Teal S Hallstrand
    Department of Medicine, Division of Pulmonary and Critical Care, University of Washington, Seattle, Washington 98195 6522, USA
    Am J Respir Crit Care Med 172:679-86. 2005
    Exercise-induced bronchoconstriction (EIB) is a highly prevalent condition with unclear pathogenesis. Two competing theories of the pathogenesis of EIB differ regarding the inflammatory basis of this condition.
  20. ncbi Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma
    Timothy D Mickleborough
    Human Performance and Exercise Biochemistry Laboratory, Department of Kinesiology, Indiana University, 1025 E Seventh St, HPER 112, Bloomington, IN 47401, USA
    Chest 129:39-49. 2006
    Previous research has demonstrated that fish oil supplementation has a protective effect on exercise-induced bronchoconstriction (EIB) in elite athletes, which may be attributed to its antiinflammatory properties...
  21. ncbi Dynamic hyperinflation with bronchoconstriction: differences between obese and nonobese women with asthma
    Tim J T Sutherland
    Respiratory Research Unit, Department of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Am J Respir Crit Care Med 177:970-5. 2008
    ..It is unclear whether the dynamic changes that occur during bronchoconstriction differ between obese versus nonobese patients with asthma.
  22. ncbi Serum leptin and adiponectin levels correlate with exercise-induced bronchoconstriction in children with asthma
    Hey Sung Baek
    Department of Pediatrics, Hanyang University School of Medicine, 17 Haengdang dong, Seoul, Korea
    Ann Allergy Asthma Immunol 107:14-21. 2011
    Exercise-induced bronchoconstriction (EIB), a form of bronchial hyperresponsiveness (BHR), is common in children with asthma or obesity...
  23. pmc S-nitrosoglutathione supplementation to ovalbumin-sensitized and -challenged mice ameliorates methacholine-induced bronchoconstriction
    Matthew W Foster
    Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 301:L739-44. 2011
    ..In conclusion, in the OVA mouse model of allergic asthma, aerosolized GSNO has rapid and sustained antibronchoconstrictive effects but does not substantially alter airway inflammation...
  24. ncbi The role of lipoxin A4 in exercise-induced bronchoconstriction in asthma
    Fulya Tahan
    Department of Pediatric Allergy, Erciyes University School of Medicine, Kayseri, Turkey
    J Asthma 45:161-4. 2008
    The pathogenesis of exercise-induced bronchoconstriction in asthma is incompletely understood, and the role of lipoxin A4 has not been investigated.
  25. ncbi Symptom perception during acute bronchoconstriction
    K J Killian
    Department of Medicine, McMaster University Medical Centre, Hamilton, Ontario, Canada
    Am J Respir Crit Care Med 162:490-6. 2000
    ..underlying the present study was that some of the variability in symptom intensity seen during acute bronchoconstriction may result from varying intensities of several stimuli yielding several sensations that can be identified ..
  26. ncbi Bronchoconstriction occurring during exercise in asthmatic subjects
    K C Beck
    Division of Thoracic Diseases, Mayo Clinic, Rochester, Minnesota 55905
    Am J Respir Crit Care Med 149:352-7. 1994
    ..05), although changes in PEF were minimal and were not significantly different compared with pre-exercise.(ABSTRACT TRUNCATED AT 250 WORDS)..
  27. ncbi Perception of bronchoconstriction in elderly asthmatics
    M Ekici
    Department of Chest Diseases, Faculty of Medicine, Kirikkale University, Turkey
    J Asthma 38:691-6. 2001
    The impaired perception of bronchoconstriction in asthmatic patients may increase the risk of severe exacerbation...
  28. ncbi Tidal breathing pattern differentially antagonizes bronchoconstriction in C57BL/6J vs. A/J mice
    Bohao Chen
    Section of Pulmonary and Critical Care Medicine, University of Chicago, 5841 S Maryland Ave, MC6026, Chicago, Illinois 60637, USA
    J Appl Physiol 101:249-55. 2006
    ..we studied the antiobstructive effect of different tidal breathing patterns in C57Bl/6J and A/J mice during bronchoconstriction induced by continuous or bolus infusion of methacholine...
  29. ncbi Effect of low temperature on tracheal smooth muscle contractile and relaxing responses evoked by electrical field stimulation
    O Gonzalez
    Department of Physiology, University of Puerto Rico, School of Medicine, PO Box 365067, San Juan, Puerto Rico 00936 5067
    P R Health Sci J 20:237-44. 2001
    ..The aim of this work was to evaluate the effect of low temperature (LT) on the contractile and relaxing responses of rat tracheas (RTs) after electrical field stimulation (EFS)...
  30. ncbi Dual effects of p38 MAPK on TNF-dependent bronchoconstriction and TNF-independent neutrophil recruitment in lipopolysaccharide-induced acute respiratory distress syndrome
    Silvia Schnyder-Candrian
    Centre National de la Recherche Scientifique, Molecular Immunology and Embryology, Orleans, France
    J Immunol 175:262-9. 2005
    ..In this study, we show that the specific p38 alpha,beta MAPK inhibitor, compound 37, prevents LPS-induced bronchoconstriction and neutrophil recruitment into the lungs and bronchoalveolar space in a dose-dependent manner in C57BL/6 ..
  31. ncbi Relation between structure, function, and imaging in a three-dimensional model of the lung
    Nora T Tgavalekos
    Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA
    Ann Biomed Eng 31:363-73. 2003
    ..An ultimate goal would be personalized predictions...
  32. ncbi Effects of xiao-qing-long-tang (XQLT) on bronchoconstriction and airway eosinophil infiltration in ovalbumin-sensitized guinea pigs: in vivo and in vitro studies
    S T Kao
    Institute of Chinese Medical Science, China Medical College, No. 91 Hsueh Shih Road, Taichung, Taiwan, ROC
    Allergy 56:1164-71. 2001
    ..Thus, XQLT may be useful for the prevention or treatment of asthma...
  33. ncbi Airway administration of Escherichia coli endotoxin to mice induces glucocorticosteroid-resistant bronchoconstriction and vasopermeation
    J Lefort
    , Institut Pasteur, Paris, France
    Am J Respir Cell Mol Biol 24:345-51. 2001
    ..with tumor necrosis factor (TNF)-alpha, in bronchoalveolar lavage fluid (BALF) were associated with bronchoconstriction and bronchopulmonary hyperreactivity (BHR) to methacholine and alveolocapillary dysfunction...
  34. ncbi Bronchoconstriction provoked by exercise in a high-particulate-matter environment is attenuated by montelukast
    Kenneth W Rundell
    Human Performance Laboratory, Marywood University, Scranton, Pennsylvania 18509, USA
    Inhal Toxicol 17:99-105. 2005
    ..004, .0006, .009, respectively). Montelukast provided greater protection against bronchoconstriction after exercise during high [PM1] than low [PM1] exposure (approximately 90% vs...
  35. ncbi Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction
    Helge Eilers
    Department of Anesthesia, University of California, San Francisco, California 94143 0427, USA
    Anesthesiology 112:1452-63. 2010
    ..This mechanism may explain the hyperalgesic actions of inhaled anesthetics and their adverse effects in the airways...
  36. ncbi Steroids completely reverse albuterol-induced beta(2)-adrenergic receptor tolerance in human small airways
    Philip R Cooper
    Department of Medicine and the Airways Biology Initiative, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Allergy Clin Immunol 122:734-40. 2008
    ..The precise mechanisms that induce beta(2)-AR tolerance remain unclear...
  37. pmc Multiple roles of nitric oxide in the airways
    F L M Ricciardolo
    Department of Respiratory Disease, Ospedal Riuniti, Bergamo, Italy
    Thorax 58:175-82. 2003
    ..The former seems to protect airways from excessive bronchoconstriction while the latter has a modulatory role in inflammatory disorders of the airways such as asthma...
  38. ncbi Bronchodilatory effect of deep inspiration on the dynamics of bronchoconstriction in mice
    Jason H T Bates
    Vermont Lung Center, University of Vermont College of Medicine, Burlington, Vermont
    J Appl Physiol (1985) 103:1696-705. 2007
    ....
  39. ncbi Exercise-induced bronchoconstriction in asthmatic children: a comparative systematic review of the available treatment options
    Tomasz Grzelewski
    N Copernicus Hospital, Department of Pediatrics and Allergy, Medical University of Lodz, 65 Pabianicka Str, Lodz, Poland
    Drugs 69:1533-53. 2009
    ..SABAs), parasympatholytics and oral leukotriene receptor antagonists in the management of exercise-induced bronchoconstriction (EIB) in children with persistent asthma (EIA)...
  40. ncbi Bronchoconstriction in nonhuman primates: a species comparison
    S Seehase
    Department of Airway Immunology, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany
    J Appl Physiol (1985) 111:791-8. 2011
    b>Bronchoconstriction is a characteristic symptom of various chronic obstructive respiratory diseases such as chronic obstructive pulmonary disease and asthma...
  41. pmc The synergistic interactions of allergic lung inflammation and intratracheal cationic protein
    Jason H T Bates
    Vermont Lung Center, Burlington, Vermont, USA
    Am J Respir Crit Care Med 177:261-8. 2008
    ..We hypothesized that more severe AHR in mice could be achieved by imbuing them with more than one mechanism of AHR...
  42. ncbi Bronchodilation and bronchoconstriction: predictors of future lung function in childhood asthma
    Kelan G Tantisira
    Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 117:1264-71. 2006
    ..Persistently low levels of lung function are associated with subsequent symptoms in patients with asthma as children...
  43. ncbi Luteolin alleviates bronchoconstriction and airway hyperreactivity in ovalbumin sensitized mice
    M Das
    Molecular Immunology and Immunogenetics Lab, Centre for Biochemical Technology, Mall Road, Delhi 110007, India
    Inflamm Res 52:101-6. 2003
    ..Asthma is an inflammatory disease of the airways and the current focus in managing asthma is the control of inflammation. In this study, we attempted to investigate the anti-asthmatic potential of a plant derived natural compound, luteolin...
  44. ncbi Dynamic hyperinflation during bronchoconstriction in asthma: implications for symptom perception
    M Diane Lougheed
    Asthma Research Unit, Department of Medicine, Queen s University, 102 Stuart St, Kingston, ON, K7L 2V6, Canada
    Chest 130:1072-81. 2006
    The objective of this study was to examine the relationship between respiratory symptom intensity and quality and dynamic lung hyperinflation (DH) during induced bronchoconstriction in asthma.
  45. ncbi Complex airway behavior and paradoxical responses to bronchoprovocation
    Tilo Winkler
    Massachusetts General Hospital and Harvard Medical School, Department of Anesthesia and Critical Care, Boston, Massachusetts 02114, USA
    J Appl Physiol (1985) 103:655-63. 2007
    ..To examine airway behavior in a bronchial tree with 12 generations, we used an integrative model of bronchoconstriction, including for each airway the effects of pressure, tethering forces, and smooth muscle forces modulated by ..
  46. ncbi Inhibition of mucin secretion with MARCKS-related peptide improves airway obstruction in a mouse model of asthma
    A Agrawal
    Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    J Appl Physiol (1985) 102:399-405. 2007
    ..In summary, mucin secretion has a significant role in airway obstruction in a mouse model of allergic asthma, and strategies to inhibit mucin secretion merit further investigation...
  47. ncbi How does exercise cause asthma attacks?
    Sandra D Anderson
    Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
    Curr Opin Allergy Clin Immunol 6:37-42. 2006
    To remind readers that evaporative water loss from the airway surface is the stimulus for exercise-induced bronchoconstriction. To emphasize that recruitment of the peripheral airways determines severity of exercise-induced ..
  48. pmc Involvement of vascular endothelial growth factor in exercise induced bronchoconstriction in asthmatic patients
    H Kanazawa
    Department of Respiratory Medicine, Graduate School of Medicine, Osaka City University, 1 4 3 Asahi machi, Abenoku, Japan
    Thorax 57:885-8. 2002
    ..microcirculation has the potential to contribute to the pathophysiological mechanisms of exercise induced bronchoconstriction (EIB) in asthmatic subjects...
  49. ncbi The structural basis of airways hyperresponsiveness in asthma
    Robert H Brown
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Appl Physiol (1985) 101:30-9. 2006
    ..These findings suggest that dynamic hyperinflation caused by narrowing of large airways is a major determinant of AHR in asthma...
  50. ncbi Protective effects of volatile agents against acetylcholine-induced bronchoconstriction in isolated perfused rat lungs
    E Lele
    Anaesthesiological Investigations Unit, University of Geneva, Geneva, Switzerland
    Acta Anaesthesiol Scand 50:1145-51. 2006
    ..study was to investigate the ability of halothane (Hal), isoflurane (Iso), sevoflurane (Sev) and desflurane (Des) to alter the lung mechanics in the absence of an airway tone and during acetylcholine (Ach)-induced bronchoconstriction.
  51. ncbi Past, present and future uses of methacholine testing
    Beth E Davis
    Department of Medicine, Division of Respirology, Critical Care and Sleep Medicine, Royal University Hospital, University of Saskatchewan, 103 Hospital Drive, Saskatoon, SK, S7N 0W8, Canada
    Expert Rev Respir Med 6:321-9. 2012
    ..The use of methacholine challenge in asthma relates to its direct effect on airway smooth muscle (i.e., bronchoconstriction) as a measure of airway hyperresponsiveness, a cardinal feature of asthma...
  52. ncbi Noninvasive measurement of midexpiratory flow indicates bronchoconstriction in allergic rats
    Thomas Glaab
    Department of Respiratory Medicine, Hannover Medical School, 30625 Hannover, Germany
    J Appl Physiol (1985) 93:1208-14. 2002
    ..This study was designed to evaluate the value and applicability of tidal breathing pattern analysis to assess bronchoconstriction in conscious rats...
  53. pmc Expression and function of human hemokinin-1 in human and guinea pig airways
    Stanislas Grassin-Delyle
    Laboratory of Pulmonary Pharmacology UPRES EA220, Foch Hospital, University Versailles Saint Quentin en Yvelines, 11 rue Guillaume Lenoir, Suresnes, France
    Respir Res 11:139. 2010
    ..Human hemokinin-1 (hHK-1) and endokinins are peptides of the tachykinin family encoded by the TAC4 gene. TAC4 and hHK-1 expression as well as effects of hHK-1 in the lung and airways remain however unknown and were explored in this study...
  54. ncbi Deep breaths, methacholine, and airway narrowing in healthy and mild asthmatic subjects
    Emanuele Crimi
    Dipartimento di Medicina Interna, Universita di Genova, 16132 Genova, Italy
    J Appl Physiol (1985) 93:1384-90. 2002
    ....
  55. ncbi Effect of montelukast or salmeterol added to inhaled fluticasone on exercise-induced bronchoconstriction in children
    Robert B Fogel
    Merck Research Laboratories, Rahway, New Jersey, USA
    Ann Allergy Asthma Immunol 104:511-7. 2010
    ..expiratory volume in 1 second (FEV1) after a standardized exercise challenge and response to rescue bronchodilation with albuterol in children aged 6 to 14 years with persistent asthma and exercise-induced bronchoconstriction (EIB).
  56. ncbi Exercise-induced bronchoconstriction in school-aged children who had chronic lung disease in infancy
    Suchita Joshi
    Department of Child Health, School of Medicine, Cardiff University, Cardiff, United Kingdom
    J Pediatr 162:813-818.e1. 2013
    To assess for exercise-induced bronchoconstriction in 8- to 12-year-old children who had chronic lung disease (CLD) in infancy, and to evaluate the response of bronchoconstriction to bronchodilation with albuterol in comparison with ..
  57. ncbi Cytokine-induced bronchoconstriction in precision-cut lung slices is dependent upon cyclooxygenase-2 and thromboxane receptor activation
    C Martin
    Faculty of Biology, University of Konstanz, Konstanz, Germany
    Am J Respir Cell Mol Biol 24:139-45. 2001
    ..slices was developed, where viable lung slices with an intact microanatomy are taken into culture and where bronchoconstriction can be followed by observing single airways under the microscope...
  58. ncbi Effect of thromboxane A2 (TXA2) synthase inhibitor and TXA2 receptor antagonist alone and in combination on antigen-induced bronchoconstriction in guinea pigs
    Y Yoshimi
    The Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan
    Prostaglandins Other Lipid Mediat 65:1-9. 2001
    Thromboxane A2 (TXA2) causes bronchoconstriction and bronchial hyperresponsiveness. Two types of TXA2 modifiers, one synthase inhibitor and one receptor antagonist, are widely used for the treatment of asthma in Japan...
  59. ncbi Deep inspiration volume and the impaired reversal of bronchoconstriction in asthma
    Kathryn M Hulme
    Medical School, University of Sydney, NSW 2006, Australia
    Respir Physiol Neurobiol 189:506-12. 2013
    It is unclear whether the failure to reverse bronchoconstriction with deep inspiration (DI) in asthma is due to reduced maximal dilatation of the DI...
  60. ncbi Airway narrowing in healthy humans inhaling methacholine without deep inspirations demonstrated by HRCT
    R H Brown
    Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 161:1256-63. 2000
    ..01), and taup (r(2) = 0.51, p = 0.0004). We conclude that in normal subjects who are prevented from taking a deep breath, the spirometric changes occurring with aerosol MCh challenge are associated with conducting airway narrowing...
  61. ncbi Involvement of mast cells in adenosine-mediated bronchoconstriction and inflammation in an allergic mouse model
    Peter J Oldenburg
    Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
    J Pharmacol Exp Ther 313:319-24. 2005
    ..4 versus 30.8%, respectively). These results support the conclusion that mast cell degranulation plays an important role in adenosine receptor-mediated airway hyperresponsiveness and inflammation...
  62. pmc Prolonged ozone exposure in an allergic airway disease model: adaptation of airway responsiveness and airway remodeling
    An Soo Jang
    Department of Internal Medicine, Soonchunhyang University Hospital, Bucheon, Gwangju, Republic of Korea
    Respir Res 7:24. 2006
    ..Because the changes in AHR and airway inflammation and structure after chronic ozone exposure need to be determined, the goal of this study was to investigate these effects in a murine model of allergic airway disease...
  63. ncbi A rho kinase inhibitor, Y-27632 inhibits pulmonary eosinophilia, bronchoconstriction and airways hyperresponsiveness in allergic mice
    Peter J Henry
    Pharmacology Unit, School of Medicine and Pharmacology, University of Western Australia, Perth 6009, Australia
    Pulm Pharmacol Ther 18:67-74. 2005
    ..whether administration of a selective inhibitor of rho kinase, Y-27632, attenuates airway inflammation, bronchoconstriction and hyperresponsiveness in a murine model of acute allergic inflammation...
  64. ncbi Bronchodilator response to albuterol after regular formoterol and effects of acute corticosteroid administration
    B J Lipworth
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK
    Chest 117:156-62. 2000
    ..There is controversy about the development of bronchodilator subsensitivity after regular administration of long-acting beta(2)-agonists...
  65. ncbi Prevalence rate of exercise-induced bronchoconstriction in Annaba (Algeria) schoolchildren
    Yasmina Benarab-Boucherit
    Service de Physiologie et d Explorations Fonctionnelles, CHU Ibn Rochd, route de Zaâfrania, 23000 Annaba, Algerie
    J Asthma 48:511-6. 2011
    We studied the prevalence rate of exercise-induced bronchoconstriction (EIB) in Annaba schoolchildren. No previous assessment of this syndrome had ever been done in Algeria.
  66. ncbi Leukotrienes as mediators of airway obstruction
    J M Drazen
    Departments of Medicine, Pulmonary Division, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 158:S193-200. 1998
    ..These data indicate that the cysteinyl leukotrienes have a clinically significant role in the airway obstruction that characterizes asthma...
  67. ncbi Embracing emerging paradigms of G protein-coupled receptor agonism and signaling to address airway smooth muscle pathobiology in asthma
    Raymond B Penn
    Department of Internal Medicine, Wake Forest University Health Sciences Center, Winston Salem, NC 27157, USA
    Naunyn Schmiedebergs Arch Pharmacol 378:149-69. 2008
    ..We further discuss the relevance of these ideas to asthma and asthma therapy, while emphasizing their potential application to the GPCR signaling in airway smooth muscle that regulates airway patency and thus disease severity...
  68. ncbi Methacholine-induced lung function changes measured with infant body plethysmography
    L Pekka Malmberg
    Department of Allergy, Helsinki University Central Hospital, Helsinki, Finland
    Pediatr Pulmonol 46:362-8. 2011
    ..but there are limited data on lung function changes measured by body plethysmography during induced bronchoconstriction. The aim of this study was to compare changes in maximum forced expiratory flow measured at functional ..
  69. pmc Unique populations of lung mast cells are required for antigen-mediated bronchoconstriction
    J M Cyphert
    Curriculum in Genetics and Molecular Biology Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Clin Exp Allergy 41:260-9. 2011
    Studies in both human and mouse indicate that mediators released by mast cells can lead to bronchoconstriction, and thus these are important effector cells in lifethreatening anaphylaxis...
  70. pmc Randomized controlled trial of fish oil and montelukast and their combination on airway inflammation and hyperpnea-induced bronchoconstriction
    Sandra Tecklenburg-Lund
    Human Performance and Exercise Biochemistry Laboratory, Department of Kinesiology, Indiana University, Bloomington, Indiana, United States of America
    PLoS ONE 5:e13487. 2010
    Both fish oil and montelukast have been shown to reduce the severity of exercise-induced bronchoconstriction (EIB)...
  71. ncbi Evaluation of association between exercise-induced bronchoconstriction and childhood asthma control test questionnaire scores in children
    Iolanda Chinellato
    Department of Paediatrics, University of Verona, Policlinico GB Rossi, Piazzale L Scuro 10, 37134 Verona, Italy
    Pediatr Pulmonol 47:226-32. 2012
    ....
  72. pmc Changes in the expression of NO synthase isoforms after ozone: the effects of allergen exposure
    An Soo Jang
    Department of Internal Medicine, Soonchunhyang University Hospital, Bucheon, 1174, Jung Dong, Wonmi gu, Bucheon si, Gyeonggi Do, 420 767 Republic of Korea
    Respir Res 5:5. 2004
    ..The functional role of nitric oxide (NO) and various nitric oxide synthase (NOS) isoforms in asthma remains unclear...
  73. pmc Safety of sputum induction with hypertonic saline solution in exercise-induced bronchoconstriction
    Chris Carlsten
    Division of Pulmonary and Critical Care, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Chest 131:1339-44. 2007
    The safety of sputum induction (SI) is well described in stable asthma, but the safety of SI in exercise-induced bronchoconstriction (EIB) has not been established.
  74. pmc Bronchoconstriction following nebulised colistin in cystic fibrosis
    S Cunningham
    Portex Anaesthesia, Intensive Care and Respiratory Medicine, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK
    Arch Dis Child 84:432-3. 2001
    ..Nebulised colistin is regularly used as antipseudomonal therapy in children with cystic fibrosis. We assessed bronchoconstriction in response to nebulised colistin in 58 children...
  75. ncbi The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthmatic subjects
    Y Taniguchi
    First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    J Allergy Clin Immunol 92:507-12. 1993
    ..0 10 minutes after the exposure. CONCLUSIONS: Therefore, we conclude that cysteinyl leukotrienes primarily mediate a later part of immediate airway obstruction after allergen exposure...
  76. ncbi Airway relaxant and anti-inflammatory properties of a PDE4 inhibitor with low affinity for the high-affinity rolipram binding site
    Christian Martin
    Division of Pulmonary Pharmacology, Research Centre Borstel, Parkallee 22, 23845 Borstel, Germany
    Naunyn Schmiedebergs Arch Pharmacol 365:284-9. 2002
    ..Up to concentrations of 10 microM none of the PDE inhibitors significantly affected bronchoconstriction elicited by 10 microM methacholine...
  77. ncbi Mucosal injury and eicosanoid kinetics during hyperventilation-induced bronchoconstriction
    A N Freed
    Department of Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Appl Physiol (1985) 87:1724-33. 1999
    ..mediator production, and 2) mucosal damage is correlated with the magnitude of hyperventilation-induced bronchoconstriction. We found that epithelial cells increased in BALF immediately after a 2- and a 5-min dry air challenge (DAC)..
  78. ncbi Nonlinearity of respiratory mechanics during bronchoconstriction in mice with airway inflammation
    Scott Wagers
    Vermont Lung Center, Department of Medicine, University of Vermont, Burlington 05405, USA
    J Appl Physiol (1985) 92:1802-7. 2002
    ..1. Significant improvement in fit (51.85 +/- 4.19%) was only seen in the ova/ova mice during bronchoconstriction when the E2V2 alone was added...
  79. ncbi Responsiveness of individual airways to methacholine in adult rat lung explants
    R J Dandurand
    Meakins Christie Laboratories, Montreal, Quebec, Canada
    J Appl Physiol (1985) 75:364-72. 1993
    ..96 x 10(-6)-5.87 x 10(-4) M). Lung inflation volume and agarose concentration affected baseline area and MR, suggesting that airway-parenchymal interdependence mechanisms are operative in this preparation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  80. ncbi Ex vivo lung function measurements in precision-cut lung slices (PCLS) from chemical allergen-sensitized mice represent a suitable alternative to in vivo studies
    M Henjakovic
    Department of Immunology, Allergology and Immunotoxicology, Fraunhofer Institute of Toxicology and Experimental Medicine, 30625 Hannover, Germany
    Toxicol Sci 106:444-53. 2008
    ..The present study suggests that the effects of low molecular weight allergens, like TMA and DNCB, on ex vivo lung functions tested in PCLS reflect the in vivo situation...
  81. ncbi Electric field stimulation of precision-cut lung slices
    Marco Schlepütz
    Institute of Pharmacology and Toxicology, Univ Hospital Aachen, Wendlingweg 2, 52074 Aachen
    J Appl Physiol (1985) 110:545-54. 2011
    ..We developed a method to study nerve-dependent bronchoconstriction by the application of electric field stimulation (EFS) to PCLS...
  82. ncbi Role of tachykinins in the bronchoconstriction induced by HCl intraesophageal instillation in the rabbit
    L Gallelli
    Department of Experimental Medicine, Section of Pharmacology Leonardo Donatelli, Faculty of Medicine and Surgery, 2nd University of Naples, Via Costantinopoli 16 80138, Naples, Italy
    Life Sci 72:1135-42. 2003
    ..Infusion of HCl induced a significant bronchoconstriction (P < 0...
  83. ncbi Sensitivity of impulse oscillometry and spirometry in beta-blocker induced bronchoconstriction and beta-agonist bronchodilatation in asthma
    Philip M Short
    Asthma and Allergy Research Group, Medical Research Institute, University of Dundee, Scotland, United Kingdom
    Ann Allergy Asthma Immunol 109:412-5. 2012
    ..Impulse oscillometry (IOS) provides an alternative method of assessing pulmonary function to conventional spirometry...
  84. ncbi Effect of inspired air conditions on exercise-induced bronchoconstriction and urinary CC16 levels in athletes
    C Bolger
    School of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
    J Appl Physiol (1985) 111:1059-65. 2011
    Injury to the airway epithelium has been proposed as a key susceptibility factor for exercise-induced bronchoconstriction (EIB)...
  85. ncbi Assessment and prevention of exercise-induced bronchoconstriction
    Sandra D Anderson
    Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia
    Br J Sports Med 46:391-6. 2012
    The assessment of exercise-induced bronchoconstriction (EIB) in athletes requires the measurement of forced expiratory volume in 1 s (FEV(1)) before and after vigorous exercise or a surrogate of exercise such as eucapnic voluntary ..
  86. pmc Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux
    Bruno D'Agostino
    Department of Experimental Medicine Section of Pharmacology, Faculty of Medicine and Surgery, 2nd University of Naples, Via Constantinopoli 16, 80138 Naples, Italy
    Br J Pharmacol 144:813-20. 2005
    ..In airways, N/OFQ was found to inhibit the release of tachykinins and the bronchoconstriction and cough provoked by capsaicin. 2...
  87. ncbi Topographic basis of bimodal ventilation-perfusion distributions during bronchoconstriction in sheep
    Marcos F Vidal Melo
    Cardiac Anesthesia Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Respir Crit Care Med 171:714-21. 2005
    The distribution of ventilation-perfusion (VA/Q) ratios during bronchoconstriction measured with the multiple inert gases elimination technique is frequently bimodal...
  88. ncbi Bronchoconstriction induced by inhaled adenosine 5'-monophosphate in subjects with allergic rhinitis
    L Prieto
    , Spain
    Eur Respir J 17:64-70. 2001
    Adenosine and its related nucleotide, adenosine 5'-monophosphate (AMP) induce bronchoconstriction in asthmatics, probably caused by histamine release from airway mast cells...
  89. ncbi Bronchodilator tolerance: the impact of increasing bronchoconstriction
    J M Wraight
    Dept of Medical and Surgical Sciences, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Eur Respir J 21:810-5. 2003
    ..to beta-agonists causes tolerance to their bronchodilator effects, which is best demonstrated during acute bronchoconstriction. The aim of the present study was to assess whether tolerance becomes more evident with increasing ..
  90. ncbi Protective effects of volatile agents against methacholine-induced bronchoconstriction in rats
    W Habre
    Division of Anesthesiological Investigations, University of Geneva, Switzerland
    Anesthesiology 94:348-53. 2001
    ..Therefore, the authors investigated the abilities of halothane, isoflurane, sevoflurane, and desflurane to provide protection against airway constriction induced by methacholine...
  91. pmc BAY u3405 an antagonist of thromboxane A2- and prostaglandin D2-induced bronchoconstriction in the guinea-pig
    H P Francis
    Bayer UK Ltd, Pharma Research, Stoke Poges
    Br J Pharmacol 104:596-602. 1991
    1. The novel thromboxane (TX) antagonist, BAY u3405, has been evaluated against bronchoconstriction induced by the TXA2 mimetic U-46619, prostaglandin D2 (PGD2), 5-hydroxytryptamine (5-HT), leukotriene D4 (LTD4) and histamine in the ..
  92. ncbi Provoked models of asthma: what have we learnt?
    P M O'Byrne
    Firestone Institute for Respiratory Health, St Joseph s Hospital, Hamilton, ON, Canada
    Clin Exp Allergy 39:181-92. 2009
    ..These stimuli induce airway narrowing 'indirectly' by causing the endogenous release of mediators of bronchoconstriction from airway inflammatory cells...
  93. pmc Effects of bronchoconstriction, minute ventilation, and deep inspiration on the composition of exhaled breath condensate
    Jason S Debley
    Department of Pediatrics, Division of Pulmonary Medicine, University of Washington, Seattle, WA 98195, USA
    Chest 139:16-22. 2011
    ..The goal of this study was to determine if the composition of EBC is affected by changes in airway caliber, minute ventilation, or forceful exhalation, factors that may differ among subjects with asthma in cross-sectional studies...
  94. ncbi Effects of inhaled monoethanolamine on bronchoconstriction
    Y Kamijo
    Department of Emergency and Critical Care Medicine, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    J Appl Toxicol 29:15-9. 2009
    ..We presently describe the mechanism of MEA-induced bronchoconstriction according to findings in guinea pigs...
  95. ncbi Exaggerated airway narrowing in mice treated with intratracheal cationic protein
    Jason H T Bates
    Vermont Lung Center, University of Vermont College of Medicine, Burlington, VT 05405 0075, USA
    J Appl Physiol (1985) 100:500-6. 2006
    ....
  96. ncbi Importance of the angiotensin type 1 receptor in angiotensin II-induced bronchoconstriction and bronchial hyperresponsiveness in the guinea pig
    Kazuyoshi Watanabe
    Division of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa Graduate University School of Medicine, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Exp Lung Res 30:207-21. 2004
    Although angiotensin II (Ang II) causes bronchoconstriction and bronchial hyperresponsiveness to methacholine in mildly asthmatic patients, the responsible mechanisms for these reactions are unclear...
  97. ncbi Physiologic implications of helium as a carrier gas for inhaled nitric oxide in a neonatal model of Bethanecol-induced bronchoconstriction
    Thomas L Miller
    Nemours Research Lung Center, Nemours Children s Clinic Wilmington of the Nemours Foundation, Alfred I duPont Children s Hospital, Wilmington, DE, USA
    Pediatr Crit Care Med 7:159-64. 2006
    ..nitrox) as a carrier gas for inducible nitric oxide (iNO) in the presence of pharmacologically inhaled bronchoconstriction. We hypothesized that respiratory resistance and gas exchange would improve when iNO is delivered with ..
  98. ncbi Paradoxical conducting airway responses and heterogeneous regional ventilation after histamine inhalation in rabbit studied by synchrotron radiation CT
    Sam Bayat
    centre hospitalier universitaire d Amiens, Cardiologie et Pneumo Allergologie Pédiatriques, 80054 Amiens Cedex 1, France
    J Appl Physiol (1985) 106:1949-58. 2009
    ..This finding provides further in vivo evidence that airway reactivity in response to inhaled histamine is complex and that airway response may vary substantially with location within the bronchial tree...
  99. pmc Specific mediator inhibition by the NO donors SNP and NCX 2057 in the peripheral lung: implications for allergen-induced bronchoconstriction
    Anna Karin Larsson
    Unit of Lung Biology, Division of Vascular and Respiratory Research, Department of Experimental Medical Science, Lund University, Lund, Sweden
    Respir Res 10:46. 2009
    ....
  100. ncbi Critical role of CD23 in allergen-induced bronchoconstriction in a murine model of allergic asthma
    G Dasic
    Department of Immunology Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development S A, Geneva, Switzerland
    Eur J Immunol 29:2957-67. 1999
    ..These results imply a novel role for CD23 in lung inflammation and suggest that anti-CD23 Fab fragment treatment may be of therapeutic use in allergic asthma...
  101. ncbi Ethnic differences: word descriptors used by African-American and white asthma patients during induced bronchoconstriction
    G E Hardie
    University of California San Francisco, School of Nursing and Department of Medicine, San Francisco, CA, USA
    Chest 117:935-43. 2000
    ..To determine if African-American and white patients with asthma (1) differ in the words they use to describe their breathlessness, and (2) differ in their perception of breathlessness...

Research Grants63

  1. Development of Montelukast Delivery System for Childhood Asthma
    Je Phil Ryoo; Fiscal Year: 2013
    ..Leukotriene receptor antagonists inhibit bronchoconstriction and prevent many types of asthmatic responses, including allergen-induced, exercise- induced, cold-air-..
  2. Lipidomic and Transcriptome Signatures in Aspirin-Exacerbated Respiratory Disease
    Joshua A Boyce; Fiscal Year: 2010
    ..inhibitors of cyclooxygenase 1 they develop acute worsening of their rhinosinusitis accompanied by acute bronchoconstriction that may be life-threatening...
  3. Development of High Affinity Analogues of Brevenal: Novel Molecular Probes for Ne
    Mary C Wolf; Fiscal Year: 2011
    ..In sheep inhalation models, brevenal blocks PbTx-induced bronchoconstriction and leads to increased tracheal mucous velocity...
  4. Regulation of airway epithelial repair
    Steven R White; Fiscal Year: 2010
    ..acts to slow this repair process, by repeated stretching and compressing airways via severe and continued bronchoconstriction that will impair MAPK-mediated migration...
  5. Synthetic surfactant and toxic chemical lung injury
    Frans J Walther; Fiscal Year: 2011
    ..provided by applicant): The major physiologic actions of inhaled toxic chemicals on the lung are bronchoconstriction and pulmonary edema...
  6. G-Protein Coupled Receptor Kinase-2 on IgE Signaling in Mast Cells
    Hydar Ali; Fiscal Year: 2012
    ..Passive systemic anaphylaxis (PSA), bronchoconstriction in precision cut murine lung slices and murine model of allergic asthma will be used to test the hypothesis ..
  7. Mechanisms of Health Effects of Exercise in Children
    Dan M Cooper; Fiscal Year: 2013
    ..whether 10 weeks of exercise training can (1) benefit asthmatic children with a history of exercise-induced bronchoconstriction and (2) attenuate obesity- associated endothelial damage-increasingly recognized as a major component of ..
  8. Respiratory Virus Induced Sensory Neuroplasticity
    Bradley J Undem; Fiscal Year: 2013
    ..virus infections) and because when they are activated it leads to coughing, reflex secretions and bronchoconstriction. We hypothesize that viral infections induce, de novo, the expression of the ligand-gated ion channels ..
  9. Secretory Phospholipase A2s in Airway Pathophysiology
    Teal S Hallstrand; Fiscal Year: 2013
    ..we strive to further elucidate the mechanism by which sPLA2-X initiates airway inflammation and mediates bronchoconstriction in asthma...
  10. Bronchodilator Effects of Toll-Like Receptor-7 Agonists.
    David B Jacoby; Fiscal Year: 2011
    ..receptor 7 (TLR7) agonists in the airways, namely that they are potent bronchodilators, and prevent bronchoconstriction caused by methacholine, histamine, stimulation of parasympathetic nerves, and depolarization of smooth ..
  11. Neonatal Modulation of Airway Contractility
    Y S Prakash; Fiscal Year: 2013
    ..previous grant cycles, we established that moderate (50%) hyperoxia in early postnatal development enhances bronchoconstriction, while impairing bronchodilation...
  12. Stability of Pullmonary Airways
    JAMES BERNARD GROTBERG; Fiscal Year: 2010
    ..which can incorporate the simultaneous issues presented by diseases such as asthma and emphysema where bronchoconstriction, parenchymal tissue elasticity changes, and fluid property modifications (non-Newtonian fluids) acting ..
  13. RGS: A Molecular Switch Regulating Irreversible ASM Growth/Contraction in Asthma
    REYNOLD ALEXANDER PANETTIERI; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Airway inflammation and reversible bronchoconstriction characterize asthma;however, in severe disease, irreversible airway obstruction and increases in airway smooth muscle (ASM) mass/growth commonly ..
  14. Asthma Exacerbation by Organophosphate Pesticides
    ALLISON DEBORAH FRYER; Fiscal Year: 2011
    ..the OP parathion did not cause hyperreactivity in non-sensitized guinea pigs but it doubled vagally-induced bronchoconstriction in sensitized animals...
  15. A multi-scale approach to airway hyperresponsiveness: from molecule to organ
    MERRYN HOWATSON TAWHAI; Fiscal Year: 2013
    ..computational model of the lung to the point where it can be used to make realistic predictions of bronchoconstriction, thereby allowing us to identify those pathophysiologic mechanisms having the greatest impact on AHR...
  16. Exhaled Nitric Oxide: Mechanisms and Limitations
    STEVEN CARL GEORGE; Fiscal Year: 2010
    ..peripheral regions of the lungs in a group of both healthy and asthmatic subjects at baseline and during bronchoconstriction using three different, but complimentary, techniques: Multiple breath nitrogen washout, positron emission ..
  17. Redistribution of pulmonary perfusion during bronchoconstriction in asthma
    ROBERT SCOTT HARRIS; Fiscal Year: 2012
    ..ventilation, take place in spontaneously breathing human subjects with asthma during methacholine-induced bronchoconstriction. The long-term objective of this research is to understand the mechanisms of, and factors that modify, the ..
  18. OGR1 is a proton-sensing GPCR in airway smooth muscle
    Raymond B Penn; Fiscal Year: 2012
    ..Neural mechanisms have been shown capable of mediating acidosis-induced bronchoconstriction, but whether reduced pH in the airway microenvironment has direct effects on airway smooth muscle (ASM) is ..
  19. Efficacy and Safety of Beta-adrenoceptor Inverse Agonist, Nadolol in Mild Asthma
    Nicola A Hanania; Fiscal Year: 2013
    ..Pharmacological management aims at reversing bronchoconstriction and combating chronic inflammation...
  20. THERAPEUTIC TARGETING OF THE GABAA CHANNEL ON AIRWAY SMOOTH MUSCLE
    George Gallos; Fiscal Year: 2013
    ..of a novel therapeutic mechanism to relax constricted airway smooth muscle following irritant induced bronchoconstriction. However, this work has the therapeutic potential to broadly impact the control of airway smooth muscle ..
  21. SP-A as an immune modulator
    Monica Kraft; Fiscal Year: 2013
    ..oxidative changes has abrogated ability to defend the host from environmental insults leading to excessive bronchoconstriction and allergic inflammation...
  22. Novel strategies for asthma therapy by regulating mast cell signaling by MyD88
    Hydar Ali; Fiscal Year: 2010
    Asthma is a complex airway inflammatory disease characterized by bronchoconstriction, airway hyperresponsiveness and inflammation...
  23. Novel Molecular Mechanisms Promote GPCR-Induced Bronchodilation in Asthma
    REYNOLD ALEXANDER PANETTIERI; Fiscal Year: 2013
    ..an improved understanding of GPCR desensitization in HASM, identify unique molecules that promote Gq-dependent bronchodilation, define novel agonists to TAS2Rs and antagonists to OGR1 to prevent bronchoconstriction.
  24. Chemokine Modulation of Airway Vagal Sensory Nerves
    CARL ROBERT POTENZIERI; Fiscal Year: 2011
    ..reflexes such as urge to cough, dyspnea, and increased cholinergic output leading to mucus secretion and bronchoconstriction to aid in the clearance of harmful substances from the airways...
  25. Regulation of CD23 Cleavage
    CAROLINE JEANNETTE PADRO; Fiscal Year: 2012
    ..An allergic asthma attack is triggered by exposure to allergens that cause bronchoconstriction, which is relieved by the administration of a beta-2-adrenergic receptor (Beta{2}AR) agonist to relax ..
  26. MECHANISMS OF AIRFLOW OBSTRUCTION
    Julian Solway; Fiscal Year: 1992
    Numerous studies have related global respiratory heat and/or water loss to the degree of bronchoconstriction induced in asthmatics by isocapnic hyperpnea of dry air...
  27. A complex systems approach to bronchoconstriction in Asthma
    Tilo Winkler; Fiscal Year: 2013
    ..This research is aimed at understanding the complex behavior of the lungs during an asthma attack, a key step needed for developing and testing therapeutic interventions to prevent or reverse asthma attacks. ..
  28. Targeting actin dynamics to inhibit airway hypperresponsiveness and inflammation
    Robert S Tepper; Fiscal Year: 2013
    ..agents and beta-adrenergic bronchodilators remain the primary treatment for chronic and acute episodes of bronchoconstriction, there is a great need for newer therapeutic targets that can modify the development and treatment of ..
  29. Therapeutic Potentiation of Bronchial Dilatation
    Julian Solway; Fiscal Year: 2012
    ..to exaggerate breathing-induced FFIR should release ASM's squeeze on the airway lumen and thus relieve bronchoconstriction. Our objective is to identify and evaluate compounds that target this extremely potent but largely ..
  30. MECHANISMS OF EXERCISE INDUCED ASTHMA IN HUMANS
    Kenneth Beck; Fiscal Year: 2000
    ..In preliminary studies, we have found that bronchoconstriction can develop during exercise using protocols with either variable work intensity or a sustained constant ..
  31. Eosinophil Mechanisms of Sensory Neuroplasticity in a Murine Model of Asthma
    GREGORY DAVID SCOTT; Fiscal Year: 2012
    ..in two asthma models and if branched outgrowth correlates with increased sensory nerve-induced reflex bronchoconstriction. Preliminary data has already demonstrated some of these changes...
  32. AIR CONDITIONING BY THE TRACHEA--STIMULI AND MECHANISMS
    Mark Deffebach; Fiscal Year: 1993
    ..b>Bronchoconstriction is also seen after CDA hyperventilation in normal subjects and experimental animals...
  33. PLATELET ACTIVATING FACTOR DEPENDENT TRANSACETYLASES
    TEN CHING LEE; Fiscal Year: 1999
    ..g., liver. lung, and intestines, etc.), bronchoconstriction, systemic hypotension, inflammatory and allergic reactions, implantation and parturition...
  34. Airway sensory nerves and dyspnea in human subjects
    Nausherwan Burki; Fiscal Year: 2004
    ..that intravenous adenosine causes dyspnea and increase ventilation, and neither affect is associated with bronchoconstriction. Adenosine is known to increase ventilation by stimulating the carotid body chemoreceptors; such reflex ..
  35. ESOPHAGO-LARYNGEAL ADDUCTOR REFLEX
    Nancy Bauman; Fiscal Year: 2000
    ..5% capsaicin to the distal esophageal mucosa to elicit an ELAR. The airway response of the ELAR (bronchoconstriction, change in respiratory rate, and laryngeal adduction) will be assessed. Esophageal stimulation with 0...
  36. THE ROLE OF HYALURONAN IN AIRWAY HYPERREACTIVITY
    Rosanna Forteza; Fiscal Year: 2005
    ..Kallidin causes vasodilatation, increases vascular permeability and leads to bronchoconstriction and airway hyperresponsiveness (AHR), all hallmarks of asthma...
  37. Efficacy of Liposomal Budesonide in Experimental Asthma
    KAMESWARI KONDURI; Fiscal Year: 2004
    ..The disease is characterized by acute bronchoconstriction, chronic inflammation, and airway remodeling which may lead to progressive, irreversible lung damage...
  38. NEUROPEPTIDES IN HYPERPNEA-INDUCED BRONCHOCONSTRICTION
    Daniel Ray; Fiscal Year: 1993
    ..in order to ascertain the pathway and mechanism of sensory nerve-effected responses in hyperpnea-induced bronchoconstriction (HIB)...
  39. ENDOGENOUS MECHANISMS REGULATING AIRWAY INFLAMMATION
    Robert Schleimer; Fiscal Year: 2003
    ..New evidence now suggests that bronchoconstriction following experimental antigen challenge of asthmatic subjects is influenced by endogenous glucocorticoids (..
  40. Clinical Trial of Acid Reflux Therapy in Asthma
    Robert Wise; Fiscal Year: 2007
    ..GERD) is frequent in asthmatics with poor asthma control, often occurs without symptoms, and can induce bronchoconstriction. Poorly controlled asthmatics are often treated for GERD with drugs that suppress gastric acid, but this ..
  41. CIRCADIAN AND WAKE-DEPENDENT ASPECTS OF RESPIRATION
    Steven Shea; Fiscal Year: 2000
    ..are changes in breathing, in the feedback system that regulates arterial blood gases, and in the degree of bronchoconstriction. These changes have serious clinical consequences in the common disorders of obstructive sleep apnea, ..
  42. ION CHANNELS AND AIRWAY SMOOTH MUSCLE ACTIVATION
    Cornelis van Breemen; Fiscal Year: 1991
    ..of the above agonist- induced contractions, so leading to the development of therapeutic control over bronchoconstriction. For this purpose we will study how the muscarinic agonist carbachol mobilizes Ca2+ from the extracellular ..
  43. Signaling and Crosstalk by Airway Prostanoid Receptors
    DENNIS MCGRAW; Fiscal Year: 2006
    Prostanoids have been implicated in the pathogenesis of bronchoconstriction and airway hyperreactivity (AHR) because they potently contract airway smooth muscle (ASM), and their levels, are elevated in asthmatic lung...
  44. Eicosanoids and GPCRs in Airway Physiology
    Beverly Koller; Fiscal Year: 2009
    ..TXA2 is a potent mediator of both bronchoconstriction and bronchial hyperreactivity in humans...
  45. Smooth Muscle Ca Release in RYR and FKBP transgenic mice
    Michael Kotlikoff; Fiscal Year: 2006
    ..reticulum of smooth muscle cells is a key event associated with contraction of the smooth muscle and bronchoconstriction of the airways...
  46. VIP AND NO IN AIRWAY INFLAMMATION AND ASTHMA
    SAMI SAID; Fiscal Year: 2000
    ..oxide (NO): 1) As cotransmitters of non-adrenergic, non-cholinergic relaxation, VIP and NO modulate the bronchoconstriction and airway hyperreactivity of asthma; 2) VIP modulates the airway inflammation and smooth muscle ..
  47. Lung Inflation and Airway Hyperresponsiveness
    N Adkinson; Fiscal Year: 2006
    ..bronchoprotective effect of lung inflation is lost in individuals with AHR and is also absent against the bronchoconstriction induced by an allergic reaction...
  48. AUTONOMIC REGULATION OF RESPIRATORY MUSCLE & SECRETION
    Alan Leff; Fiscal Year: 1992
    ..Preliminary data indicate that sympathetic secretion does not modulate bronchomotor tone during exogenous bronchoconstriction. Studies are proposed to examine further the effects of specific circulating mediators and physiological ..
  49. Obstruction in Asthma--Role of Airway Closure
    Andrew Jackson; Fiscal Year: 2003
    ..absence of bronchodilation, which occurs in non-asthmatics in response to a deep inspiration the excessive bronchoconstriction, or AHR, in asthma may be principally due to the failure of reflex responses in mechanical forces that ..
  50. ION CHANNELS IN AIRWAY SMOOTH MUSCLE
    Michael Kotlikoff; Fiscal Year: 1991
    ..Further, the cellular mechanism or mechanisms by which important mediators of bronchoconstriction such as leukotrienes and histamine trigger contraction in airway smooth muscle is not known...
  51. RESPIRATORY SENSATION IN NORMAL AND ASTHMATIC CHILDREN
    Paul Davenport; Fiscal Year: 2004
    ..Specifically, the sensory processes mediating bronchoconstriction, respiratory load perception and subsequent behavioral responses in asthmatic children...
  52. VAGAL AFFERENTS--SENSATIONS ARISING FROM THE LUNG
    Robert Banzett; Fiscal Year: 2000
    ..Sensations resulting from various stimuli applied to the lung including bronchoconstriction and localized lobar or segment lung inflation and lung collapse will be performed in normal subjects, ..
  53. Stress and Immunity in Pediatric Asthma
    Jack Nassau; Fiscal Year: 2004
    ..Research indicates that 20-25% of people with asthma experience stress-related bronchoconstriction that is hypothesized to be mediated by the autonomic nervous system...
  54. Exercise, Pollution, and Neutrophils in Pediatric Asthma
    CHRISTINA DANELL SCHWINDT; Fiscal Year: 2010
    ..neutrophils, neutrophil adhesion molecules, and neutrophit oxidative stress mechanisms that play a role in bronchoconstriction. Air pollution sensitizes neutrophils rendering them more prone to release these factors when environment ..
  55. Aquaporin 5 (AQP5) in Lung Fluid Homeostasis
    CARISSA KRANE; Fiscal Year: 2004
    ..Mice deficient in AQP5 are hyperresponsive to cholinergic-stimulated bronchoconstriction (narrowing of the airways), a clinical feature of asthma...
  56. REGULATION FUNCTION OF AIRWAY PROTEASES
    GEORGE CAUGHEY; Fiscal Year: 1990
    The broad objective of the proposed project is to clarify the molecular pathology of bronchoconstriction, hyperreactivity, and mucous hypersecretion...
  57. Vaccine-enhanced respiratory syncytial virus disease
    FERNANDO POLACK; Fiscal Year: 2004
    ..Recently, we established a mouse model of enhanced RSV disease that uses bronchoconstriction and pneumonia, characteristic and serious manifestations of RSV disease and vaccine-enhanced RSV disease in ..
  58. LEUKOTRIENES AND LEUKOCYTE/VASCULAR CELL INTERACTIONS
    STEVEN FEINMARK; Fiscal Year: 1993
    Local production of leukotriene (LT)C4 has been implicated in vasospasm, bronchoconstriction and the regulation of vascular permeability...
  59. ANTAGONIST OF A2B ADENOSINE RECEPTORS FOR ASTHMA
    ROBERT FIGLER; Fiscal Year: 2001
    ..Adapted from the Investigator's Abstract): Adenosine administered as an aerosol to asthmatics causes bronchoconstriction, while in non-asthmatics adenosine causes bronchodilation...
  60. CHEMORECEPTION AND SIGNAL PROCESSING IN VAGAL AFFERENTS
    Daniel Weinreich; Fiscal Year: 2006
    ..is of particular interest because these neurons play an important role in the life-threatening reflex bronchoconstriction that occurs during anaphylactic reactions...
  61. MACROPHAGE LIPOXYGENASE PATHWAY: POSSIBLE ROLE IN ASTHMA
    Timothy Bigby; Fiscal Year: 1991
    ..and monocytes, in the lung and examine the relationship of stimulation and activation of these cells to bronchoconstriction and airway hyperresponsiveness...
  62. ADENOSINE A2B RECEPTORS IN HUMAN MAST CELLS
    Igor Feoktistov; Fiscal Year: 2001
    ..studies, therefore, have the potential to better explain the observation that inhaled adenosine provokes bronchoconstriction in asthmatics in vivo...
  63. Nitric Oxide and the Beneficial effect of Lung Inflation
    George Pyrgos; Fiscal Year: 2007
    ..This becomes apparent because healthy individuals in the absence of Dl develop bronchoconstriction to methacholine which is easily preventable and reversible with deep inspirations, Dl-induced ..