respiratory mechanics

Summary

Summary: The physical or mechanical action of the LUNGS; DIAPHRAGM; RIBS; and CHEST WALL during respiration. It includes airflow, lung volume, neural and reflex controls, mechanoreceptors, breathing patterns, etc.

Top Publications

  1. ncbi Effect of obesity on respiratory mechanics during rest and exercise in COPD
    Josuel Ora
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    J Appl Physiol (1985) 111:10-9. 2011
  2. ncbi Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients
    Paolo Palange
    Dipartimento di Medicina Clinica, Servizio di Fisiopatologia Respiratoria, Universita La Sapienza, v le Universita 37, 00185 Rome, Italy
    J Appl Physiol (1985) 97:1637-42. 2004
  3. pmc Structural and functional architecture of respiratory networks in the mammalian brainstem
    Jeffrey C Smith
    Porter Neuroscience Research Center, Building 35, Room 3C 917, 35 Convent Drive, NINDS, NIH, Bethesda, MD 20892, USA
    Philos Trans R Soc Lond B Biol Sci 364:2577-87. 2009
  4. ncbi The forced oscillation technique in clinical practice: methodology, recommendations and future developments
    E Oostveen
    Dept of Pulmonary Medicine, University Hospital Antwerp, Belgium
    Eur Respir J 22:1026-41. 2003
  5. ncbi Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome
    Davide Chiumello
    Dipartimento di Anestesia, Rianimazione, Intensiva e Subintensivae, Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico Mangiagalli Regina Elena di Milano, Milan, Italy
    Am J Respir Crit Care Med 178:346-55. 2008
  6. ncbi Calculation and prediction of the effect of respiratory motion on whole breast radiation therapy dose distributions
    Junsheng Cao
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA
    Med Dosim 34:126-32. 2009
  7. ncbi Effects of obesity on breathing pattern, ventilatory neural drive and mechanics
    Mehdi Chlif
    Laboratory of Exercise Physiology and Rehabilitation, Picardie Jules Verne University, Sport Science Department, Avenue P Claudel, Amiens Cedex, France
    Respir Physiol Neurobiol 168:198-202. 2009
  8. ncbi A continuous 4D motion model from multiple respiratory cycles for use in lung radiotherapy
    Jamie R McClelland
    Centre of Medical Image Computing at University College London, Gower Street, London, WC1E 6BT United Kingdom
    Med Phys 33:3348-58. 2006
  9. ncbi Unsteady flow characteristics through a human nasal airway
    Jong Hoon Lee
    Department of Mechanical Engineering, Konkuk University, Seoul, Republic of Korea
    Respir Physiol Neurobiol 172:136-46. 2010
  10. ncbi Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable
    Denis E O'Donnell
    Department of Medicine, Queen s University, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Proc Am Thorac Soc 4:145-68. 2007

Research Grants

  1. The Role of Lung Volumes in Nocturnal Asthma
    ROBERT LLEWELLYN OWENS; Fiscal Year: 2013
  2. Epithelial JNK-TGFb1 Signaling Axis in Airway Remodeling
    Yvonne M W Janssen-Heininger; Fiscal Year: 2013
  3. Dyspnea on Exertion in Obesity: Effects of Exercise Training and Weight Loss
    Tony G Babb; Fiscal Year: 2013
  4. Respiratory Mechanics in Lung Disease and Surgery
    Stephen H Loring; Fiscal Year: 2010
  5. Respiratory Control in Old Age
    Gary C Sieck; Fiscal Year: 2013
  6. TOXICOLOGY OF COMBUSTION GENERATED ACID AEROSOLS
    MARY AMDUR; Fiscal Year: 1991
  7. BREATHING PATTERN VARIATION AND MECHANICAL INFLUENCES
    JOHN DAUBENSPECK; Fiscal Year: 1980
  8. MATHEMATICAL MODELS OF BRANCHING IN THE HUMAN LUNG
    Henry Feldman; Fiscal Year: 1980
  9. Think big, from voice to limb movement rehabilitation
    Becky Farley; Fiscal Year: 2004
  10. FIRST WORLD CONGRESS OF BIOMECHANICS
    RICHARD SKALAK; Fiscal Year: 1990

Detail Information

Publications316 found, 100 shown here

  1. ncbi Effect of obesity on respiratory mechanics during rest and exercise in COPD
    Josuel Ora
    Respiratory Investigation Unit, Department of Medicine, Queen s University and Kingston General Hospital, Kingston, Ontario, Canada
    J Appl Physiol (1985) 111:10-9. 2011
    ..Potential contributory factors included alterations in the elastic properties of the lungs, raised intra-abdominal pressures, reduced lung hyperinflation, and preserved inspiratory capacity...
  2. ncbi Effect of heliox on lung dynamic hyperinflation, dyspnea, and exercise endurance capacity in COPD patients
    Paolo Palange
    Dipartimento di Medicina Clinica, Servizio di Fisiopatologia Respiratoria, Universita La Sapienza, v le Universita 37, 00185 Rome, Italy
    J Appl Physiol (1985) 97:1637-42. 2004
    ..71; P < 0.01). In chronic obstructive pulmonary disease, heliox breathing improves high-intensity exercise endurance capacity by increasing maximal ventilatory capacity and by reducing lung DH and Dys...
  3. pmc Structural and functional architecture of respiratory networks in the mammalian brainstem
    Jeffrey C Smith
    Porter Neuroscience Research Center, Building 35, Room 3C 917, 35 Convent Drive, NINDS, NIH, Bethesda, MD 20892, USA
    Philos Trans R Soc Lond B Biol Sci 364:2577-87. 2009
    ....
  4. ncbi The forced oscillation technique in clinical practice: methodology, recommendations and future developments
    E Oostveen
    Dept of Pulmonary Medicine, University Hospital Antwerp, Belgium
    Eur Respir J 22:1026-41. 2003
    The forced oscillation technique (FOT) is a noninvasive method with which to measure respiratory mechanics. FOT employs small-amplitude pressure oscillations superimposed on the normal breathing and therefore has the advantage over ..
  5. ncbi Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome
    Davide Chiumello
    Dipartimento di Anestesia, Rianimazione, Intensiva e Subintensivae, Terapia del Dolore, Fondazione IRCCS, Ospedale Maggiore Policlinico Mangiagalli Regina Elena di Milano, Milan, Italy
    Am J Respir Crit Care Med 178:346-55. 2008
    ..Lung injury caused by a ventilator results from nonphysiologic lung stress (transpulmonary pressure) and strain (inflated volume to functional residual capacity ratio)...
  6. ncbi Calculation and prediction of the effect of respiratory motion on whole breast radiation therapy dose distributions
    Junsheng Cao
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USA
    Med Dosim 34:126-32. 2009
    ..With this model, the dosimetric coverage difference introduced by respiratory motion could be evaluated during patient CT simulation. An appropriate treatment method can be chosen after the simulation...
  7. ncbi Effects of obesity on breathing pattern, ventilatory neural drive and mechanics
    Mehdi Chlif
    Laboratory of Exercise Physiology and Rehabilitation, Picardie Jules Verne University, Sport Science Department, Avenue P Claudel, Amiens Cedex, France
    Respir Physiol Neurobiol 168:198-202. 2009
    ..It is concluded that obese subjects show impairment in breathing pattern and respiratory mechanics as assessed by rapid shallow breathing leading to ventilatory failure.
  8. ncbi A continuous 4D motion model from multiple respiratory cycles for use in lung radiotherapy
    Jamie R McClelland
    Centre of Medical Image Computing at University College London, Gower Street, London, WC1E 6BT United Kingdom
    Med Phys 33:3348-58. 2006
    ..6 mm. The mean discontinuity between model predictions at the slab boundaries, the Continuity Error, was 2.2 mm. The results show that the motion models perform with a level of accuracy comparable to the slice thickness of 1.5 mm...
  9. ncbi Unsteady flow characteristics through a human nasal airway
    Jong Hoon Lee
    Department of Mechanical Engineering, Konkuk University, Seoul, Republic of Korea
    Respir Physiol Neurobiol 172:136-46. 2010
    ..Analysis of the temperature field showed that most of the temperature change occurs in the nasal cavity when the air is incoming and thus, the nasal cavity acts as a very efficient heat exchanger during an inspiration period...
  10. ncbi Pathophysiology of dyspnea in chronic obstructive pulmonary disease: a roundtable
    Denis E O'Donnell
    Department of Medicine, Queen s University, 102 Stuart Street, Kingston, ON, K7L 2V6 Canada
    Proc Am Thorac Soc 4:145-68. 2007
    ..Self-management strategies address the affective aspect of dyspnea and are essential to successful treatment...
  11. pmc Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms
    J C Smith
    Cellular and Systems Neurobiology Section, Porter Neuroscience Research Center, NINDS, NIH, Bethesda, MD 20892, USA
    J Neurophysiol 98:3370-87. 2007
    ..We conclude that the respiratory network has rhythmogenic capabilities at multiple levels of network organization, allowing expression of motor patterns specific for various physiological and pathophysiological respiratory behaviors...
  12. pmc Dynamic correlation between whisking and breathing rhythms in mice
    Ying Cao
    Department Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Neurosci 32:1653-9. 2012
    ..High-frequency whisking and sniffing behaviors are not correlated. We conclude that whisking and respiratory rhythms are generated by independent pattern-generating mechanisms...
  13. ncbi Obesity hypoventilation syndrome: a review of epidemiology, pathophysiology, and perioperative considerations
    Edmond H L Chau
    Department of Anesthesiology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Anesthesiology 117:188-205. 2012
    ..This review will examine the epidemiology, pathophysiology, clinical characteristics, screening, and treatment of OHS. Perioperative management of OHS will be discussed last...
  14. ncbi Using physiological models and decision theory for selecting appropriate ventilator settings
    S E Rees
    Center for Model Based Medical Decision Support Systems, Aalborg University, Niels Jernes Vej 14, 4 313, DK 9220, Aalborg East, Denmark
    J Clin Monit Comput 20:421-9. 2006
    ..To present a decision support system for optimising mechanical ventilation in patients residing in the intensive care unit...
  15. ncbi The effects of tidal volume and respiratory rate on oxygenation and respiratory mechanics during laparoscopy in morbidly obese patients
    Juraj Sprung
    Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA
    Anesth Analg 97:268-74, table of contents. 2003
    ..Arterial oxygenation during laparoscopy was affected only by body weight and could not be improved by increasing either the V(T) or RR...
  16. pmc Small airway obstruction in patients with rheumatoid arthritis
    Shunsuke Mori
    Department of Rheumatology, Clinical Research Center for Rheumatic Disease, NHO Kumamoto Saishunsou National Hospital, 2659 Suya, Kohshi, Kumamoto, 861 1196, Japan
    Mod Rheumatol 21:164-73. 2011
    ..Factors significantly associated with abnormal FEF(25-75) are respiratory symptoms, smoking history, and RA duration...
  17. ncbi Neural respiratory drive in obesity
    J Steier
    Chest Unit, King s College London School of Medicine, Denmark Hill, London, UK
    Thorax 64:719-25. 2009
    ..The load imposed on ventilation by increased body mass contributes to the respiratory symptoms caused by obesity. A study was conducted to quantify ventilatory load and respiratory drive in obesity in both the upright and supine postures...
  18. ncbi Changes in respiratory mechanics with increasing degrees of airway obstruction in COPD: detection by forced oscillation technique
    Ana Maria G T Di Mango
    Biomedical Instrumentation Laboratory, Institute of Biology and Faculty of Engineering, Brazil
    Respir Med 100:399-410. 2006
    The Forced Oscillation Technique (FOT) is a method for non-invasively assessing respiratory mechanics during spontaneous breathing, demanding little cooperation...
  19. ncbi Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation
    Richard A Johnston
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    J Appl Physiol (1985) 104:1727-35. 2008
    ..However, mice with DIO must remain obese for an extended period of time before this pulmonary phenotype is observed...
  20. pmc Distinct rhythm generators for inspiration and expiration in the juvenile rat
    Wiktor A Janczewski
    Department of Neurobiology, David Geffen School of Medicine, Los Angeles, CA 90095 1763, USA
    J Physiol 570:407-20. 2006
    ....
  21. ncbi ARDSnet ventilatory protocol and alveolar hyperinflation: role of positive end-expiratory pressure
    Salvatore Grasso
    Universita di Bari, Dipartimento dell Emergenza e Trapianti d Organo DETO, Sezione di Anestesiologia e Rianimazione, Ospedale Policlinico, Piazza Giulio Cesare 11, Bari 70124, Italy
    Am J Respir Crit Care Med 176:761-7. 2007
    ....
  22. ncbi Influence of respiratory rate on stroke volume variation in mechanically ventilated patients
    Daniel De Backer
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Anesthesiology 110:1092-7. 2009
    ....
  23. ncbi Plethysmographic estimation of thoracic gas volume in apneic mice
    Tibor Z Janosi
    Dept of Medical Informatics, Univ of Szeged, Koranyi fasor 9, H 6720 Szeged, Hungary
    J Appl Physiol 101:454-9. 2006
    ..This method is particularly useful when TGV is to be determined in the absence of breathing activity, when it must be known at any level of lung inflation or under non-steady-state conditions, such as during pharmaceutical interventions...
  24. ncbi Neural correlates of voluntary breathing in humans
    L C McKay
    National Heart and Lung Instiute, Imperial College London, London W6 8RP, United Kingdom
    J Appl Physiol 95:1170-8. 2003
    ..012). Activity within the medulla suggests that the brain stem respiratory centers may have a role in mediating the voluntary control of breathing in humans...
  25. ncbi Flow limitation and dynamic hyperinflation: key concepts in modern respiratory physiology
    P M A Calverley
    Clinical Science Centre, University Hospital Aintree, Livepool, UK
    Eur Respir J 25:186-99. 2005
    ..This review focuses on how these conditions are defined and assessed and what evidence there is that they might be important in lung disease...
  26. ncbi Attenuation correction of PET images with respiration-averaged CT images in PET/CT
    Tinsu Pan
    Department of Imaging Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Nucl Med 46:1481-7. 2005
    ..We therefore proposed the use of respiration-averaged CT (ACT) to match the temporal resolution of CT and PET and evaluated the improvement of tumor quantification in PET images of the thorax with ACT...
  27. ncbi Reduced pulmonary function is associated with central arterial stiffness in men
    M Zureik
    National Institute of Health and Medical Research, Unit 258, Villejuif, France
    Am J Respir Crit Care Med 164:2181-5. 2001
    ..This study suggests that reduced pulmonary function is independently associated with aortic stiffness in men. The interrelations between pulmonary and vascular alterations should be thoroughly investigated...
  28. pmc Positive end-expiratory pressure at minimal respiratory elastance represents the best compromise between mechanical stress and lung aeration in oleic acid induced lung injury
    Alysson Roncally S Carvalho
    Biomedical Engineering Program, COPPE, Federal University of Rio de Janeiro, Av, Horácio Macedo, CT Bloco H 327, 2030, 21941 914, Rio de Janeiro, Brazil
    Crit Care 11:R86. 2007
    ....
  29. ncbi Time domains of the hypoxic ventilatory response
    F L Powell
    Department of Medicine and White Mountain Research Station University of California, San Diego, La Jolla 92093 0623, USA
    Respir Physiol 112:123-34. 1998
    ..Understanding the mechanisms for different time domains of the HVR has important implications for both basic and clinical science...
  30. ncbi Variable tidal volumes improve lung protective ventilation strategies in experimental lung injury
    Peter M Spieth
    Department of Anesthesiology and Intensive Care Therapy, University Hospital Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Am J Respir Crit Care Med 179:684-93. 2009
    ..Noisy ventilation with variable Vt may improve respiratory function in acute lung injury...
  31. ncbi Using ventilator graphics to identify patient-ventilator asynchrony
    Jon O Nilsestuen
    Department of Respiratory Care, University of Texas Medical Branch, School of Allied Health Sciences, 301 University Boulevard, Galveston TX 77555 1028, USA
    Respir Care 50:202-34; discussion 232-4. 2005
    ..Bedside evaluation for the presence of auto-PEEP should be routinely performed and corrective adjustments made when appropriate...
  32. ncbi Positive end-expiratory pressure after a recruitment maneuver prevents both alveolar collapse and recruitment/derecruitment
    Jeffrey M Halter
    Department of Surgery, State University of New York Upstate Medical University, 750 E Adams Street, Syracuse, NY 13210, USA
    Am J Respir Crit Care Med 167:1620-6. 2003
    ..This suggests recruitment followed by inadequate PEEP permits unstable alveoli and may result in ventilator-induced lung injury despite improved oxygenation...
  33. ncbi Effects of undernutrition on respiratory mechanics and lung parenchyma remodeling
    Cristina Márcia Dias
    Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Centro de Ciencias da Saude, Ilha do Fundao, 21949 900 Rio de Janeiro, Brazil
    J Appl Physiol 97:1888-96. 2004
    ....
  34. ncbi Volume dependence of airway and tissue impedances in mice
    Peter D Sly
    Division of Clinical Sciences, Telethon Institute for Child Health Research, School of Child Health, University of Western Australia, West Perth, Western Australia 6875, Australia
    J Appl Physiol (1985) 94:1460-6. 2003
    ..The expected pattern of changes in respiratory mechanics with increasing lung volume was seen: a progressive fall in airway resistance and increases in the ..
  35. ncbi Aerosolized perfluorocarbon improves gas exchange and pulmonary mechanics in preterm lambs with severe respiratory distress syndrome
    Xabier Murgia
    Research Unit for Experimental Neonatal Respiratory Physiology, Cruces University Hospital, Bizkaia, Spain
    Pediatr Res 72:393-9. 2012
    ..Aerosolized perfluorocarbon (PFC) has been proposed as an alternative method of PFC administration; however, the efficacy of aerosolized PFC in a preterm animal model has not yet been demonstrated...
  36. ncbi In vitro experiments and numerical simulations of airflow in realistic nasal airway geometry
    Céline Croce
    Fonctions Cellulaires et Moléculaires de l Appareil Respiratoire et des Vaisseaux, Equipe Biomécanique Cellulaire et Respiratoire, INSERM UMR 651, Creteil, France
    Ann Biomed Eng 34:997-1007. 2006
    ....
  37. ncbi Non-contact respiratory monitoring system using a ceiling-attached microwave antenna
    Maki Uenoyama
    Department of Management Systems Engineering, Tokyo Metropolitan University, 6 6 Asahigaoka, Hino, Tokyo, 191 0065, Japan
    Med Biol Eng Comput 44:835-40. 2006
    ..001 for healthy volunteers, r=0.98, P<0.0001 for elderly volunteers). The system could monitor subtle changes in respiratory rate, and monitoring respiratory rate increases caused by disorders such as pneumonia will be possible...
  38. pmc Neonatal maternal separation and enhancement of the hypoxic ventilatory response in rat: the role of GABAergic modulation within the paraventricular nucleus of the hypothalamus
    Sophie Emmanuelle Genest
    Pediatrics Unit, Centre de Recherche du Centre Hospitalier Universitaire de Québec, QC, Canada G1L 3L5
    J Physiol 583:299-314. 2007
    ..Together, these results show that the life-long consequences of NMS are far reaching as they can compromise the development of vital homeostatic function in a way that may predispose to respiratory disorders...
  39. ncbi Analysis of diaphragm movement during tidal breathing and during its activation while breath holding using MRI synchronized with spirometry
    P Kolar
    Department of Rehabilitation, Second Medical Faculty, Charles University, Motol, Czech Republic
    Physiol Res 58:383-92. 2009
    ..Although the sample is small, this study confirms that the function of the diaphragm is not only respiratory but also postural and can be voluntarily controlled...
  40. pmc Respiratory mechanics during exercise in endurance-trained men and women
    Jordan A Guenette
    School of Human Kinetics and Faculty of Medicine, Health and Integrative Physiology Laboratory, University of British Columbia, 6108 Thunderbird Blvd, Vancouver, BC, Canada V6T 1Z3
    J Physiol 581:1309-22. 2007
    ..Collectively, these findings suggest that women utilize a greater majority of their ventilatory reserve compared to men and this is associated with a higher cost of breathing...
  41. pmc Streaking artifacts reduction in four-dimensional cone-beam computed tomography
    Shuai Leng
    Department of Medical Physics, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    Med Phys 35:4649-59. 2008
    ..At the same time, a temporal gating window as narrow as 100 ms was utilized. Compared to the conventional 4D CBCT reconstruction, streaking artifacts were reduced by 60% to 70%...
  42. ncbi Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD
    Koichi Nishimura
    Respiratory Division, Kyoto Katsura Hospital, Kyoto, Japan
    Chest 121:1434-40. 2002
    ....
  43. ncbi Detection of expiratory flow limitation in COPD using the forced oscillation technique
    R L Dellaca
    TBMLab, Dipartimento di Bioingegneria, Politecnico di Milano University, Milan, Italy
    Eur Respir J 23:232-40. 2004
    ..Within-breath respiratory system reactance provides an accurate, reliable and noninvasive technique to detect expiratory flow limitation in patients with chronic obstructive pulmonary disease...
  44. ncbi The effects of pneumoperitoneum on respiratory mechanics during general anesthesia for bariatric surgery
    Abdelazeem Ali El-Dawlatly
    Department of Anaesthesia, College of Medicine, King Saud University, King Khalid University Hospital, Riyadh, Saudia Arabia
    Obes Surg 14:212-5. 2004
    The effects of pneumoperitoneum (PPM) on respiratory mechanics during bariatric surgery were investigated.
  45. pmc Pressure-dependent stress relaxation in acute respiratory distress syndrome and healthy lungs: an investigation based on a viscoelastic model
    Steven Ganzert
    Department of Anesthesiology and Critical Care Medicine, University Medical Center, Freiburg, D 79106 Freiburg, Germany
    Crit Care 13:R199. 2009
    ..In this study, stress relaxation of mechanically ventilated lungs was investigated, focusing on non-linear dependence on pressure. The range of inspiratory capacity was analyzed up to a plateau pressure of 45 cmH2O...
  46. ncbi Mechanical ventilation in acute respiratory failure: recruitment and high positive end-expiratory pressure are necessary
    Carmen Silvia Valente Barbas
    Division of Pulmonary and Critical Care, University of Sao Paulo, Sao Paulo, Brazil and Intensive Care Unit, Albert Einstein Hospital, Sao Paulo, Brazil
    Curr Opin Crit Care 11:18-28. 2005
    ....
  47. pmc Respiratory restriction and elevated pleural and esophageal pressures in morbid obesity
    Negin Behazin
    Dept of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol (1985) 108:212-8. 2010
    ..High P(Es) suggests high P(Pl) in such individuals. Lung and respiratory system compliances are low because of breathing at abnormally low lung volumes...
  48. ncbi Magnetic resonance imaging and computed tomography of respiratory mechanics
    Jürgen Biederer
    Department of Diagnostic Radiology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    J Magn Reson Imaging 32:1388-97. 2010
    ..Near isotropic 4D-MRI can be used to assess tumor displacement, chest wall invasion, and segmental respiratory mechanics. Limited temporal resolution of dynamic volume acquisitions (in their current implementation) may lead to ..
  49. ncbi Effects of pneumoperitoneum and positioning on respiratory mechanics in chronic obstructive pulmonary disease patients during Nissen fundoplication
    Ziya Salihoglu
    Medical Faculty of Cerrahpasa, University of Istanbul, Istanbul, Turkey
    Surg Laparosc Endosc Percutan Tech 18:437-40. 2008
    The aim of this study was to evaluate the effects of pneumoperitoneum and patient positioning on respiratory mechanics and blood gases in chronic obstructive pulmonary disease (COPD) patients during laparoscopic Nissen fundoplication.
  50. pmc Electroencephalographic evidence for pre-motor cortex activation during inspiratory loading in humans
    Mathieu Raux
    Universite Pierre et Marie Curie PARIS6, UPRES EA 2397, Paris, France
    J Physiol 578:569-78. 2007
    ..g. asthma attacks) would have important pathophysiological implications: it could for example contribute to explain why sleep is both altered and deleterious in such situations...
  51. ncbi Bronchial inflammation and colonization in patients with clinically stable bronchiectasis
    J Angrill
    Servei de Pneumologia, , Spain
    Am J Respir Crit Care Med 164:1628-32. 2001
    ....
  52. ncbi Proteoglycan fragmentation and respiratory mechanics in mechanically ventilated healthy rats
    Andrea Moriondo
    Dipartimento di Scienze Biomediche Sperimentali e Cliniche, Universita degli Studi dell Insubria, via J H Dunant 5, 21100 Varese, Italy
    J Appl Physiol 103:747-56. 2007
    ..severely affects the pulmonary extracellular architecture, exposing the lung parenchyma to development of ventilator-induced lung injury; and 2) respiratory mechanics is not a reliable clinical tool for early detection of lung injury.
  53. pmc Respiratory pulse pressure variation fails to predict fluid responsiveness in acute respiratory distress syndrome
    Karim Lakhal
    Service de Réanimation Médicale et Maladies Infectieuses, Hopital Bichat Claude Bernard, Assistance Publique des Hopitaux de Paris, 18 rue Henri Huchard, F 75018 Paris, France
    Crit Care 15:R85. 2011
    ..We aimed to assess ΔRESPPP in a large ARDS population...
  54. ncbi Relationship between dynamic respiratory mechanics and disease heterogeneity in sheep lavage injury
    Carissa L Bellardine Black
    Department of Biomedical Engineering, Boston University, Boston, MA, USA
    Crit Care Med 35:870-8. 2007
    ....
  55. ncbi Prolonged moderate pressure recruitment manoeuvre results in lower optimal positive end-expiratory pressure and plateau pressure
    K Lowhagen
    Department of Anaesthesia and Intensive Care Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Acta Anaesthesiol Scand 55:175-84. 2011
    ..Secondly, optimal PEEP levels following the RMs were compared, and the use of volume-dependent compliance (VDC) to identify successful lung recruitment and optimal PEEP was evaluated...
  56. ncbi Studying rhythmogenesis of breathing: comparison of in vivo and in vitro models
    D W Richter
    Dept of Physiology II, Georg August Universitat Gottingen, 37073, Gottingen, Germany
    Trends Neurosci 24:464-72. 2001
    ..We have taken note of these in formulating a 'maturational network-burster model' for rhythm generation that includes most features of the existing models of respiratory rhythm generation...
  57. ncbi Effect of bronchodilation on expiratory flow limitation and resting lung mechanics in COPD
    R L Dellaca
    Dipartimento di Bioingegneria, Politecnico di Milano, TBM Lab, Milano, Italy
    Eur Respir J 33:1329-37. 2009
    ..However, changes in EELV are consistently seen, irrespective of the presence of flow limitation at rest...
  58. ncbi Lung mechanics and dyspnea during exacerbations of chronic obstructive pulmonary disease
    Nicola J Stevenson
    Department of Medicine, Clinical Sciences Centre, University Hospital Aintree, Longmoor Lane, Liverpool L9 7AL, UK
    Am J Respir Crit Care Med 172:1510-6. 2005
    ..Exacerbation of chronic obstructive pulmonary disease commonly causes hospitalization. The change in lung mechanics during exacerbation and its relationship to symptoms in spontaneously breathing individuals has not been described...
  59. ncbi Mechanics, nonlinearity, and failure strength of lung tissue in a mouse model of emphysema: possible role of collagen remodeling
    Satoru Ito
    Dept of Biomedical Engineering, Boston Univ, 44 Cummington St, Boston MA 02215, USA
    J Appl Physiol 98:503-11. 2005
    ..001) associated with a 29% lower elastance along the quasi-static pressure-volume curves (P < 0.001). Respiratory mechanics were measured at several positive end-expiratory pressures in the closed-chest condition...
  60. ncbi Noninvasive and invasive pulmonary function in mouse models of obstructive and restrictive respiratory diseases
    Jeroen A J Vanoirbeek
    Lung Toxicology Research Unit, Katholieke Universiteit Leuven, Herestraat 49 bus 706, Leuven, Belgium
    Am J Respir Cell Mol Biol 42:96-104. 2010
    ..Invasive pulmonary functions allow distinction between respiratory diseases in mice by clinically relevant variables, and should become standard in the functional evaluation of pathological disease models...
  61. ncbi Expiratory flow limitation and intrinsic positive end-expiratory pressure in obesity
    W Pankow
    Department of Internal Medicine, Medizinische Poliklinik, Schlafmedizinisches Labor, Philipps University Marburg, D 32033 Marburg, Germany
    J Appl Physiol (1985) 85:1236-43. 1998
    ..We conclude that in OS 1) tidal breathing can be affected by EFL and PEEPi; 2) EFL and PEEPi are promoted by the supine posture; and 3) the increased diaphragmatic load in the supine position is, in part, related to PEEPi...
  62. ncbi Respiratory parameters during professional flute playing
    I Cossette
    Meakins Christie Laboratories, McGill University, 3626 rue St Urbain, Quebec, H2X 2PZ, Montreal, Canada
    Respir Physiol 121:33-44. 2000
    ..We conclude that while different flautists use different strategies to control Pm, the results are similar. Independent control of V and Vel by Pm and Aem allow flautists to control I and F regardless of how Pm is generated...
  63. ncbi Mild obesity does not limit change in end-expiratory lung volume during cycling in young women
    T G Babb
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and The University of Texas Southwestern Medical Center, Dallas, Texas 77231, USA
    J Appl Physiol (1985) 92:2483-90. 2002
    ..All subjects underwent respiratory mechanics measurements in the supine and seated positions, and during graded cycle ergometry to exhaustion...
  64. ncbi Assessment of respiratory mechanics in small animals: the simpler the better?
    Zoltan Hantos
    J Appl Physiol 93:1196-7. 2002
  65. ncbi Two-compartment modelling of respiratory system mechanics at low frequencies: gas redistribution or tissue rheology?
    T Similowski
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Eur Respir J 4:353-8. 1991
    ..Recently, however, there has been considerable interest in modelling low-frequency respiratory mechanics in terms of two compartments, since this gives a much improved description of experimental data...
  66. ncbi Effects of abdominal distension on breathing pattern and respiratory mechanics in rabbits
    Edgardo D'Angelo
    Istituto di Fisiologia Umana I, Universita degli Studi di Milano, Cattedra VI, Via Mangiagalli 32, 20133, Milan, Italy
    Respir Physiol Neurobiol 130:293-304. 2002
    ..Hence, reduced respiratory system compliance and changes in inspiratory muscle electromechanical efficiency dominate lung volume responses to acute AD...
  67. ncbi Acute asthma in adults: a review
    Gustavo J Rodrigo
    Departamento de Emergencia, Hospital Central de las Fuerzas Armadas, Montevideo, Uruguay
    Chest 125:1081-102. 2004
    ..This review describes the epidemiology, costs, pathophysiology, mortality, and management of adult AA in the ED and in the ICU...
  68. ncbi Assessment of respiratory mechanics in patients with sarcoidosis using forced oscillation: correlations with spirometric and volumetric measurements and diagnostic accuracy
    Alvaro C D Faria
    Biomedical Instrumentation Laboratory, Institute of Biology and Faculty of Engineering, State University of Rio de Janeiro, Rio de Janeiro, Brazil
    Respiration 78:93-104. 2009
    The forced oscillation technique (FOT) is a promising method for providing a detailed analysis of respiratory mechanics during spontaneous breathing. There is limited data about the use of FOT in patients with sarcoidosis.
  69. pmc Peripheral chemoreflex and baroreflex interactions in cardiovascular regulation in humans
    John R Halliwill
    Department of Exercise and Movement Science, University of Oregon, 122 Esslinger Hall, Eugene, OR 97403 1240, USA
    J Physiol 552:295-302. 2003
    ..Furthermore, these effects appear largely independent of breathing rate and tidal volume...
  70. ncbi Breathing rhythms and emotions
    Ikuo Homma
    Department of Physiology, Showa University School of Medicine, Hatanodai 1 5 8, Shinagawa ku, Tokyo 142 8555, Japan
    Exp Physiol 93:1011-21. 2008
    ..In particular, we discuss oscillations of piriform-amygdala complex activity and respiratory rhythm...
  71. ncbi Technique to determine inspiratory impedance during mechanical ventilation: implications for flow limited patients
    D W Kaczka
    Department of Biomedical Engineering, Boston University, MA 02215, USA
    Ann Biomed Eng 27:340-55. 1999
    ..We conclude that the EVW offers a potentially practical and efficient approach to monitor lung function in ventilator-dependent patients, especially those with expiratory flow limitation...
  72. ncbi Dyspnea and decreased variability of breathing in patients with restrictive lung disease
    Thomas Brack
    Division of Pulmonary and Critical Care Medicine, Edward Hines Jr, Veterans Affairs Hospital, Hines, Illinois 60141, USA
    Am J Respir Crit Care Med 165:1260-4. 2002
    ..97; p < 0.001). In conclusion, patients with restrictive lung disease adopt a tightly constrained breathing pattern, probably as a strategy for avoiding dyspnea...
  73. ncbi Effects of minimal invasive coronary artery bypass on pulmonary function and postoperative pain
    A Lichtenberg
    Division of Thoracic and Cardiovascular Surgery, Hannover Medical School, Germany
    Ann Thorac Surg 70:461-5. 2000
    ..We investigated whether this fact may lead to less postoperative pain and improved pulmonary function...
  74. ncbi Variable ventilation improves perioperative lung function in patients undergoing abdominal aortic aneurysmectomy
    Abdulaziz Boker
    Department of Anesthesia and Critical Care, Abdulaziz University, Jeddah, Saudi Arabia
    Anesthesiology 100:608-16. 2004
    ..VV was compared with CV in patients undergoing abdominal aortic aneurysmectomy, a patient group known to be at risk of deteriorating lung function perioperatively...
  75. ncbi Quantifying fractal dynamics of human respiration: age and gender effects
    C K Peng
    Margret and H A Rey Institute for Nonlinear Dynamics in Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Ann Biomed Eng 30:683-92. 2002
    ....
  76. pmc Controlled inspiration depth reduces variance in breath-holding-induced BOLD signal
    Moriah E Thomason
    Stanford University School of Medicine, Neurosciences Program, Department of Radiology, Stanford, CA 94305, USA
    Neuroimage 39:206-14. 2008
    ..The implications of these findings for routine BH studies of BOLD-derived neurovascular response are discussed...
  77. ncbi Physiological definition of upper airway obstructions in mouse model for Rett syndrome
    Nicolas Voituron
    Mp3 Respiration Team, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille CRN2 M, Unité Mixte de Recherche 6231, CNRS Université Aix Marseille II and III, Faculté Saint Jérôme, 13397 Marseille Cedex 20, France
    Respir Physiol Neurobiol 173:146-56. 2010
    ..The observed breath-hold events in Mecp2(-/y) mice might imply disturbance of neural circuits attached to voluntary control of breathing...
  78. ncbi Helium-hyperoxia, exercise, and respiratory mechanics in chronic obstructive pulmonary disease
    Neil D Eves
    Rehabilitation Medicine, University of Calgary, Calgary, AB, Canada T2N 1N4
    Am J Respir Crit Care Med 174:763-71. 2006
    ..Combining these gases could have an additive effect on dynamic hyperinflation and a greater impact on respiratory mechanics and exercise tolerance.
  79. ncbi High-resolution computed tomographic evaluation of airway distensibility and the effects of lung inflation on airway caliber in healthy subjects and individuals with asthma
    R H Brown
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
    Am J Respir Crit Care Med 163:994-1001. 2001
    ..Therefore, the mechanism for reduced bronchodilation after DIs in subjects with mild asthma could be intrinsic to the airway smooth muscle...
  80. ncbi Estimation of time-varying respiratory mechanical parameters by recursive least squares
    A M Lauzon
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    J Appl Physiol (1985) 71:1159-65. 1991
    ..These results demonstrate that our recursive estimator is able to track rapid changes in respiratory mechanical parameters during bronchoconstrictor challenge...
  81. ncbi Neonatal maternal separation induces sex-specific augmentation of the hypercapnic ventilatory response in awake rat
    Sophie Emmanuelle Genest
    Pediatrics, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Universite Laval, Quebec, Canada
    J Appl Physiol 102:1416-21. 2007
    ..We conclude that NMS exerts sex-specific effects on the hypercapnic ventilatory response and that the neural mechanisms affected by NMS likely differ from those involved in the hypoxic chemoreflex...
  82. ncbi Airway pressure release ventilation as a primary ventilatory mode in acute respiratory distress syndrome
    T Varpula
    Department of Anesthesiology and Intensive Care Medicine, Jorvi Hospital, Helsinki University Hospital, Espoo, Finland
    Acta Anaesthesiol Scand 48:722-31. 2004
    ....
  83. pmc Esophageal pressures in acute lung injury: do they represent artifact or useful information about transpulmonary pressure, chest wall mechanics, and lung stress?
    Stephen H Loring
    Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol (1985) 108:515-22. 2010
    ..We suggest that Pes can be used to estimate transpulmonary pressures that are consistent with known physiology and can provide meaningful information, otherwise unavailable, in critically ill patients...
  84. ncbi A bilateral cortico-bulbar network associated with breath holding in humans, determined by functional magnetic resonance imaging
    Leanne C McKay
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Neuroimage 40:1824-32. 2008
    ..From these results we speculate that the pons has a role in integrating information from supra-brainstem structures, and in turn it exerts an inhibitory effect on medullary respiratory neurones to inhibit breathing during breath holding...
  85. ncbi Obesity and asthma: lessons from animal models
    Stephanie A Shore
    Program in Molecular and Integrative Physiological Sciences, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    J Appl Physiol (1985) 102:516-28. 2007
    ..Understanding the mechanistic basis for the relationship between obesity and asthma may lead to novel therapeutic strategies for treatment of the obese asthmatic subject...
  86. ncbi The effect of leptin on the ventilatory responseto hyperoxia
    Harald Groeben
    Department of Anesthesiology and Critical Care Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
    Exp Lung Res 30:559-70. 2004
    ..Leptin deficiency abolishes the response to hyperoxia, which is restored by leptin replacement. Thus, leptin seems to be influential for a competent peripheral chemoreceptor function...
  87. ncbi Heart rate variability during exercise performed below and above ventilatory threshold
    Francois Cottin
    Laboratory of Exercise Physiology and Genetics, Department of Sport and Exercise Science, University of Evry, Evry Cedex, France
    Med Sci Sports Exerc 36:594-600. 2004
    ..To examine whether differences in heart rate variability (HRV) can distinguish sub- from supra-ventilatory-threshold exercise and whether the exercise duration at supra-threshold intensity alters cardiorespiratory synchronization...
  88. pmc Forced oscillation technique in the detection of smoking-induced respiratory alterations: diagnostic accuracy and comparison with spirometry
    Alvaro Camilo Dias Faria
    Biomedical Instrumentation Laboratory, Institute of Biology, Faculty of Engineering, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil
    Clinics (Sao Paulo) 65:1295-304. 2010
    ..However, there have been no data concerning the use of the forced oscillation technique to evaluate respiratory mechanics in groups with different degrees of tobacco consumption.
  89. ncbi Neurally adjusted ventilatory assist improves patient-ventilator interaction
    Lise Piquilloud
    Intensive Care Unit, Clinical Research Laboratory, University Hospital, Faculty of Medicine, University of Geneva, Rue Gabrielle Perret Gentil 4, 1211 Geneva 14, Switzerland
    Intensive Care Med 37:263-71. 2011
    ..To determine if, compared with pressure support (PS), neurally adjusted ventilatory assist (NAVA) reduces trigger delay, inspiratory time in excess, and the number of patient-ventilator asynchronies in intubated patients...
  90. ncbi Mild-to-moderate obesity: implications for respiratory mechanics at rest and during exercise in young men
    D S DeLorey
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, TX 75231, USA
    Int J Obes (Lond) 29:1039-47. 2005
    To investigate the effect of mild-to-moderate obesity on respiratory mechanics at rest and during exercise in obese men...
  91. ncbi Poor agreement between respiratory variations in pulse oximetry photoplethysmographic waveform amplitude and pulse pressure in intensive care unit patients
    Svein Aslak Landsverk
    Department of Anesthesiology, Ulleval University Hospital, Oslo, Norway
    Anesthesiology 109:849-55. 2008
    ..Based on knowledge of slow oscillation in skin blood flow, the authors hypothesized that the variability of DeltaPOP would be larger than that of DeltaPP when calculations were performed continuously over a long recording period...
  92. ncbi A minimal model of lung mechanics and model-based markers for optimizing ventilator treatment in ARDS patients
    Ashwath Sundaresan
    Center for Bioengineering, Department of Mechanical Engineering, University of Canterbury, Private Bag 4800, Christchurch, New Zealand
    Comput Methods Programs Biomed 95:166-80. 2009
    ..This minimal model thus provides a clinically useful and relatively simple platform for continuous patient specific monitoring of lung unit recruitment for a patient...
  93. ncbi Noninvasive monitoring of respiratory mechanics during sleep
    R Farre
    Unitat de Biofisica i Bioenginyeria, Facultat de Medicina, Casanova 143, E 08036 Barcelona, Spain
    Eur Respir J 24:1052-60. 2004
    ..Noninvasive assessment of respiratory mechanics during sleep is helpful in facilitating the diagnosis and treatment of patients with sleep apnoea-..
  94. pmc Within-breath analysis of respiratory mechanics in asthmatic patients by forced oscillation
    Juliana Veiga
    Biomedical Instrumentation Laboratory, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro RJ, Brazil
    Clinics (Sao Paulo) 64:649-56. 2009
    The within-breath analysis of respiratory mechanics by the monofrequency Forced Oscillation Technique (mFOT) is of great interest in both physiopathology studies and the diagnosis of respiratory diseases...
  95. pmc Pontine respiratory activity involved in inspiratory/expiratory phase transition
    Michael Mörschel
    Department of Neuro and Sensory Physiology, University Medicine Gottingen, Georg August University, Humboldtallee 23, 37073 Gottingen, Germany
    Philos Trans R Soc Lond B Biol Sci 364:2517-26. 2009
    ..The involvement of these putative interactions in pontine-mediated control of IE phase transitions is discussed...
  96. ncbi [Effects of manually assisted coughing on respiratory mechanics in patients requiring full ventilatory support]
    Katia de Miranda Avena
    Centro Universitario do Triangulo, Uberlandia, MG, Brasil
    J Bras Pneumol 34:380-6. 2008
    ..Due to routine use of MAC in intensive care units, the objective of this study was to assess the effects of MAC on respiratory system mechanics in patients requiring full ventilatory support...
  97. ncbi Big breathing: the complex interaction of obesity, hypoventilation, weight loss, and respiratory function
    Amanda J Piper
    Sleep Unit, Level 11, E Block, Royal Prince Alfred Hospital, Missenden Rd, Camperdown, NSW 2050, Australia
    J Appl Physiol (1985) 108:199-205. 2010
    ..Attention to this residual abnormality is important given the high incidence of cardiovascular abnormalities, including pulmonary hypertension, in individuals with OHS...
  98. ncbi Acute ventilatory failure complicating obesity hypoventilation: update on a 'critical care syndrome'
    Ahmed BaHammam
    The University Sleep Disorders Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Curr Opin Pulm Med 16:543-51. 2010
    ..OHS patients may present with acute-on-chronic ventilatory failure, necessitating acute care management. The purpose of this review is to discuss the recent literature on acute ventilatory failure in OHS patients...
  99. ncbi Changes in respiratory mechanics among infants undergoing heart surgery
    Stephen A Stayer
    Department of Anesthesiology, Division of Pediatric Cardiovascular Anesthesiology, Baylor College of Medicine, Texas Children s Hospital, 6621 Fannin, WT 19345H, Houston, TX 77030 2399, USA
    Anesth Analg 98:49-55, table of contents. 2004
    Children with excessive pulmonary blood flow (PBF) from congenital heart disease have abnormal respiratory mechanics. Exposure to hypothermic cardiopulmonary bypass (CPB) adversely affects lung function...
  100. ncbi Identification of bronchodilator responsiveness by forced oscillation admittance in children
    Yen Thi Nguyen
    Service d Explorations Fonctionnelles Pédiatriques, Hôpital d Enfants, Centre Hospitalier Universitaire de Nancy, F 54511 Vandoeuvre les Nancy, France
    Pediatr Res 62:348-52. 2007
    ..Both estimates were significantly correlated (p < 0.0001). The change in Ars may thus be useful to avoid the upper airway artefact when assessing the response to salbutamol using the FOT in young children...
  101. ncbi The effect of angiotensin-converting enzyme inhibition by captopril on respiratory mechanics in healthy rats
    Alessandro Rubini
    Department of Human Anatomy and Physiology, Section Physiology, University of Padova, Via Marzolo, Padova, Italy
    J Enzyme Inhib Med Chem 27:854-60. 2012
    ..Angiotensin stimulates smooth-muscle contraction. Accordingly, angiotensin-converting enzyme (ACE) inhibition is expected to decrease airway resistance...

Research Grants62

  1. The Role of Lung Volumes in Nocturnal Asthma
    ROBERT LLEWELLYN OWENS; Fiscal Year: 2013
    ..His research efforts have focused on respiratory mechanics, with two projects to date resulting in first author publications...
  2. Epithelial JNK-TGFb1 Signaling Axis in Airway Remodeling
    Yvonne M W Janssen-Heininger; Fiscal Year: 2013
    ..of house dust mite-induced epithelial to mesenchymal transition, airways fibrosis, and altered respiratory mechanics in vivo, and utilize mice that globally lack JNK1, or specifically within the bronchiolar epithelium, ..
  3. Dyspnea on Exertion in Obesity: Effects of Exercise Training and Weight Loss
    Tony G Babb; Fiscal Year: 2013
    ..in which exercise training would be dramatically beneficial, or to obesity-related changes in respiratory mechanics, in which aggressive weight loss measures may be necessary before exercise training can be tolerated...
  4. Respiratory Mechanics in Lung Disease and Surgery
    Stephen H Loring; Fiscal Year: 2010
    ..Results of these studies may suggest changes in the management of mechanical ventilation that will improve outcome in ARDS. ..
  5. Respiratory Control in Old Age
    Gary C Sieck; Fiscal Year: 2013
    ..three specific aims to address these hypotheses: 1) To determine the functional impact of old age on respiratory mechanics;2) To determine the role of BDNF/TrkB signaling on the age-related changes in DIAm innervation;and 3) To ..
  6. TOXICOLOGY OF COMBUSTION GENERATED ACID AEROSOLS
    MARY AMDUR; Fiscal Year: 1991
    ..Functional change during exposure is evaluated by measurement of respiratory mechanics. Pulmonary function following exposure is evaluated by measurement of lung volumes, C0 diffusing capacity, ..
  7. BREATHING PATTERN VARIATION AND MECHANICAL INFLUENCES
    JOHN DAUBENSPECK; Fiscal Year: 1980
    ..of respiratory control will be experimentally tested: 1) to determine quantitative relationships between respiratory mechanics and both the chemical control of ventilation and the selection of the breathing pattern and the influence ..
  8. MATHEMATICAL MODELS OF BRANCHING IN THE HUMAN LUNG
    Henry Feldman; Fiscal Year: 1980
    ..in the branching structure, and will be applicable as a practical tool for calculation of variables of respiratory mechanics. Comparison of the principles and numerical parameters of design will be made between regions of the human ..
  9. Think big, from voice to limb movement rehabilitation
    Becky Farley; Fiscal Year: 2004
    ..g., articulation, speaking rate, swallowing, respiratory mechanics)...
  10. FIRST WORLD CONGRESS OF BIOMECHANICS
    RICHARD SKALAK; Fiscal Year: 1990
    ..The topics to be covered include: Molecular and cellular mechanics, cardiovascular mechanics, respiratory mechanics, dental mechanics, orthopaedics and musculoskeletal mechanics, muscle mechanics and sports medicine, ..
  11. EFFECT OF ANESTHESIA ON RESPIRATORY MECHANICS IN ANIMALS
    PETER SOUTHORN; Fiscal Year: 1980
    ..The majority of animals did exhibit, with anesthesia a decrease in their awake functional residual capacity. This decrease was correlated with a decrease in outward chest wall recoil...
  12. SYMPTOM PERCEPTION IN CRITICAL ADOLESCENT ASTHMA
    Anthony Mansell; Fiscal Year: 2004
    ..is that some adolescent asthmatics have innate deficiencies in their abilities to assess compromises in respiratory mechanics or gas exchange...
  13. Time-Dependent Changes in Respiratory Control After Perinatal Hyperoxia
    RYAN BAVIS; Fiscal Year: 2008
    ..Therefore, it is critical to understand how environmental conditions in early life influence development of protective chemoreflexes. [unreadable] [unreadable] [unreadable]..
  14. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 2008
    ..Such information might provide insights into dysfunctions of the control of ventilation in humans, such as in "sleep apnea" or the "sudden infant death syndrome." [unreadable] [unreadable] [unreadable]..
  15. ORGANIZATION OF CENTRAL SYMPATHETIC PATHWAYS
    PATRICE GUYENET; Fiscal Year: 2008
    ..The research will contribute to the basic physiological knowledge needed to understand how syrr pathetic tone is regulated in health and in diseases such as arrhythmias, hypertension and dysautonomias. ..
  16. MECHANICS OF ACUTE LUNG INJURY
    Jason Bates; Fiscal Year: 2009
    ..The results of our studies are expected to lead to the design of physiologically-based lung recruitment strategies that can be tailored to the individual patient with ALI. This will set the stage for future clinical trials. ..
  17. Assessment of Lung function in Mice
    Jason Bates; Fiscal Year: 2009
    ....
  18. CENTRAL NEURONAL MECHANISMS--DECOMPENSATED HEMORRHAGE
    PATRICE GUYENET; Fiscal Year: 2003
    ..Understanding the neurophysiological mechanisms triggered by hypotensive hemorrhage should lead to improved ability to manage this all too frequent clinical problem. ..
  19. CSF AND THE CENTRAL CHEMICAL CONTROL OF BREATHING
    Eugene Nattie; Fiscal Year: 2008
    ..abstract_text> ..
  20. Development of a Novel Gas Embolotherapy Technique
    JOSEPH BULL; Fiscal Year: 2005
    ..The proposed research is an essential first step in developing this potentially revolutionary technique. ..
  21. Integrity of the Pulmonary Blood-Gas Barrier
    John West; Fiscal Year: 2007
    ..In addition, at the more basic level, this research is devoted to a fundamental biological dilemma of the lung, namely how the blood-gas barrier combines extreme thinness with immense strength. [unreadable] [unreadable]..
  22. Coupling & Reconfiguration of Rhythmic Motor Networks
    Stephen Johnson; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  23. Speech Kinematics in Parkinson's Disease
    Jessica Huber; Fiscal Year: 2004
    ....
  24. Respiratory Control Stability in Obstructive Sleep Apnea
    David Wellman; Fiscal Year: 2004
    ..b. High LG, independent of upper airway collapsibility, is associated with more severe (more frequently apneas) OSA. c. Lower LG will reduce OSA severity in patients with high LG. ..
  25. PLASTICITY OF SPINAL RESPIRATORY SYNAPTIC TRANSMISSION
    Stephen Johnson; Fiscal Year: 2001
    ....
  26. Pulmonary Vascular Tree Development, Growth & Remodling
    Robb Glenny; Fiscal Year: 2005
    ..The findings will fill important gaps in our knowledge of pulmonary vascular development and triggers of remodeling. ..
  27. Functional Plasticity in Hypoglossal Motoneurons
    JACK FELDMAN; Fiscal Year: 2008
    ..If these pathologies are to be understood, the mechanisms controlling the output of respiratory motoneurons needs to be determined. ..
  28. Respiratory activities of intrinsic tongue muscles
    E Bailey; Fiscal Year: 2004
    ....
  29. Critical Role of Alveolar Fibrin in Acute Lung Injury
    Gilman Allen; Fiscal Year: 2008
    ..abstract_text> ..
  30. The Effect of Pulmonary Interstitial Edema on Gas Exchange
    G Prisk; Fiscal Year: 2009
    ..3) Define and quantify the relationship between alterations in the heterogeneity of pulmonary blood flow and lung water content using functional magnetic resonance imaging (fMRI) and X-ray techniques. ..
  31. INTRACELLULAR PH RESPONSES OF CENTRAL CHEMORECEPTORS
    Robert Putnam; Fiscal Year: 2009
    ..We are studying the ways in which neurons respond to CO2 to identify novel drug targets and to test a new theory that this pathway involves several different signals. ..
  32. Control of breathing during physiological conditions
    Hubert V Forster; Fiscal Year: 2010
    ....
  33. CEREBELLUM--ROLE IN THE CHEMICAL CONTROL OF BREATHING
    Fadi Xu; Fiscal Year: 2003
    ..Perhaps, more exciting is the emerging concept that the cerebellum may be far more involved in the planning and executing of motor responses, including respiration, than we have heretofore imagined. ..
  34. Regional Hypoxic Pulmonary Vasoconstriction
    MICHAEL HLASTALA; Fiscal Year: 2006
    ..The results of the research will provide a more detailed understanding of the local and cellular mechanisms responsible for HPVR heterogeneity and mechanisms of development of disease in the mammalian lung. [unreadable] [unreadable]..
  35. Background sodium currents in respiratory pacemakers
    ANDREW TRYBA; Fiscal Year: 2009
    ..This research will lead to better understanding of the ionic mechanisms behind the generation of regular versus irregular rhythmic respiratory activity. ..
  36. Impact of intermittent hypoxia on ventilatory drive and apnea severity
    JASON HAROLD MATEIKA; Fiscal Year: 2010
    ..This treatment could be particularly useful in individuals who suffer from mild or moderate forms of OSA when used in conjunction with other potential innovative therapies. ..
  37. Deposition of 0.5 to 2 Micron Aerosol in the Human Lung
    G Prisk; Fiscal Year: 2003
    ..5 to 1 micron). Such information will provide a much-improved basis for the assessment of exposure to small inhaled particles both in long duration spaceflight and on Earth. ..
  38. NEUROMUSCULAR CONTROL OF THE PHARYNGEAL AIRWAY
    RALPH FREGOSI; Fiscal Year: 2002
    ..These experiments will lay the foundation for new and improved treatment strategies for persons with obstructive sleep apnea or with other conditions that are caused by malfunction of the tongue motor system. ..
  39. Oxidative stress and aortic valve disease
    Jordan Miller; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  40. Development of SAMMA based vaginal microbiocide
    Michael Oldham; Fiscal Year: 2006
    ..3. EFFICACY. The new formulations will also be evaluated for activity against sperm, chlamydia and HSV utilizing in vitro assays and the mouse model. [unreadable] [unreadable] [unreadable]..
  41. Central Mechanisms of Respiratory Arrest
    Fadi Xu; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  42. Improving Respiratory Outcomes in ALS
    Noah Lechtzin; Fiscal Year: 2006
    ..Lechtzin the opportunity to expand the skills required for development into an independent clinical investigator. ..
  43. HEART RATE VARIABILITY IN SLEEP-DISORDERED BREATHING
    MICHAEL KHOO; Fiscal Year: 2005
    ....
  44. DYNAMICS OF ALVEOLAR RECRUITMENT IN LUNG INJURY
    Robert Harris; Fiscal Year: 2005
    ..SA3 will compare local measurements of recruitment by PET with the global measures of recruitment by NO uptake kinetics and lung mechanics. ..
  45. Heart Rate Variability in Mecp2 Deficient Mice
    JOHN BISSONNETTE; Fiscal Year: 2005
    ..These studies will contribute to the understanding of depressed parasympathetic activity in Rett syndrome. ..
  46. Superoxide and Vascular Function in Heart Failure
    Jordan Miller; Fiscal Year: 2007
    ..Collectively, these studies will lend important insights into the role of oxidative stress and vascular function in HF. [unreadable] [unreadable] [unreadable]..
  47. PREDOCTORAL TRAINING PROGRAM IN NEUROSCIENCE
    RALPH FREGOSI; Fiscal Year: 2008
    ..Facilities for research training include the extensive equipment and expertise in individual faculty laboratories, as well as comprehensive shared resources at the University of Arizona. ..
  48. CONTROL OF BREATHING IN RECOVERY FROM APNEA
    Bradley Thach; Fiscal Year: 2008
    ..Louis, MO.) of infants dying suddenly and unexpectedly to determine if post mortem body temperature indicates involvement of overheating or disorders of thermoregulation in SIDS. [unreadable] [unreadable]..
  49. Effects of lung water on mechanics and blood flow
    Angela Henderson; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  50. EXPIRATORY MUSCLE ACTIVATION TO PRODUCE COUGH
    Anthony DiMarco; Fiscal Year: 2003
    ..Restoration of affective cough mechanism may allow patients with spinal cord injury to clear secretions more easily, reduce the incidence of respiratory complication and, ultimately, improve their life quality. ..
  51. Spinal Cord Stimulation to Restore Cough In Humans
    Anthony DiMarco; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  52. Combined Intercostal and Diaphragm Pacing
    Anthony DiMarco; Fiscal Year: 2004
    ....
  53. Improved 3D MRI with cylindrical trajectories
    David Feinberg; Fiscal Year: 2004
    ..During the commercialization phase the developed set of pulse sequences will be ported for suitable hardware and software platforms of all major MR hardware manufacturers. ..
  54. Neuromorphic Electronic Model of Synaptic Plasticity
    Chi Sang Poon; Fiscal Year: 2006
    ..unreadable] [unreadable]..